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Rani M Priya MP Agroprocessing and Natural Products Division, National Institute for Interdisciplinary Science and Technology (NIIST), CSIR, Trivandrum, Kerala, 695019, - - 2014
Stereospermum colais (family Bignoniaceae) is a well-known pharmacologically potent medicinal plant reported in traditional systems of medicine. Phytochemical investigation of the roots of S. colais resulted in the isolation of seven compounds, and the metabolites were screened for its α-glucosidase enzyme inhibition and anti-glycation property. The compounds identified were β-sitosterol ...
Selma Maria V MV - - 2014
Urolithins are dibenzypyranone metabolites that exert anti-inflammatory activity in vivo and are produced by the gut microbiota from the dietary polyphenols ellagic acid (EA) and ellagitannins. However, the identification of bacteria involved in this process remains unknown. We report here a new bacterium, capable of metabolizing EA to urolithins, isolated ...
Hevekerl Antje A Thünen-Institute of Agricultural Technology, Bundesallee 50, 38116, Braunschweig, - - 2014
Itaconic acid is an important industrial building block and is produced by the filamentous fungi Aspergillus terreus. To make the optimization process more efficient, a scale-down from shake flasks to microtiter plates was performed. This resulted in comparable product formations, and 87.7 g/L itaconic acid was formed after 10 days of cultivation ...
Yurchenko Olga O 1 University of - - 2014
Low molecular mass (10 kD) cytosolic acyl-CoA binding protein (ACBP) has a substantial influence over fatty acid (FA) composition in oilseeds, possibly via an effect on the partitioning of acyl groups between elongation and desaturation pathways. Previously, we demonstrated that expression of a Brassica napus ACBP (BnACBP) cDNA in the ...
Zhou Yuqing Y Beijing Bioprocess Key Laboratory, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, PR - - 2014
This work investigated the capability of Rhizopus arrhizus to assimilate biodiesel-derived crude glycerol and convert it into fumaric acid. After optimizing the initial glycerol concentration, spore inoculum and yeast extract concentration, smaller pellets (0.7mm) and higher biomass (3.11g/L) were obtained when R. arrhizus grew on crude glycerol. It was found ...
Schmidt Moritz J MJ Department of Chemistry, University of Konstanz, Universitätsstrasse 10, 78457 Konstanz - - 2014
The site-selective introduction of photo-crosslinking groups into proteins enables the discovery and mapping of weak and/or transient protein interactions with high spatiotemporal resolution, both in vitro and in vivo. We report the genetic encoding of a furan-based, photo-crosslinking amino acid in human cells; it can be activated with red light, ...
Gauglitz Julia M JM Department of Chemistry and Biochemistry, University of California , Santa Barbara, California 93106-9510, United - - 2014
Marine bacteria produce an abundance of suites of acylated siderophores characterized by a unique, species-dependent headgroup that binds iron(III) and one of a series of fatty acid appendages. Marinobacter sp. DS40M6 produces a suite of seven acylated marinobactins, with fatty acids ranging from saturated and unsaturated C12-C18 fatty acids. In ...
Wang Pei P State Key Lab of Urban and Regional Ecology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China; Graduate University of Chinese Academy of Sciences, Beijing 100049, - - 2014
Perfluoroalkyl acids (PFAAs) are emerging contaminants that have raised great concern in recent years. While PFAAs manufacturing becomes regulated in developed countries, production has been partly shifted to China. Eight fluoropolymer manufacturing facilities located in the South Bohai coastal region, one of the most populated areas of China, have been ...
Milner Stephen J SJ Department of Chemistry, University of York, Heslington, York YO10 5DD, - - 2014
A series of structurally related citric acid-ciprofloxacin conjugates was synthesised to investigate the influence of the linker between citric acid and ciprofloxacin on antibacterial activities. Minimum inhibitory concentrations (MICs) were determined against a panel of reference strains and clinical isolates of bacteria associated with infection in humans and correlated with ...
Sciubba Fabio F a Istituto di Cristallografia, Consiglio Nazionale delle Ricerche (CNR) , via G. Amendola, 122/O 70126, Bari , - - 2014
High-resolution proton NMR spectroscopy was performed on three Italian hazelnut cultivars, Tonda di Giffoni, Mortarella and Tonda Gentile Romana, and it allowed to define their metabolic profile. The hazelnuts were grown in the same pedoclimatic conditions in the Monti Cimini (Latium) area. The samples were obtained by using a modified ...
Romagnoli Gabriele G Department of Biotechnology, Delft University of Technology, Julianalaan 67, 2628 BC, Delft, The Netherlands; Kluyver Centre for Genomics of Industrial Fermentation, P.O. Box 5057, 2600 GA, Delft, The - - 2014
Its characteristic rose-like aroma makes phenylethanol a popular ingredient in foods, beverages and cosmetics. Microbial production of phenylethanol currently relies on whole-cell bioconversion of phenylalanine with yeasts that harbor an Ehrlich pathway for phenylalanine catabolism. Complete biosynthesis of phenylethanol from a cheap carbon source such as glucose provides an economically ...
Mohamed Gamal A GA a Department of Natural Products , Faculty of Pharmacy, King Abdulaziz University , Jeddah 21589 , Saudi - - 2014
Chemical investigation of the Red Sea sponge Mycale euplectellioides afforded two new compounds; hexacosa-(6Z,10Z)-dienoic acid methyl ester (1) and hexacosa-(6Z,10Z)-dienoic acid (2), along with two known compounds: icosa-(8Z,11Z)-dienoic acid methyl ester (3) and β-sitosterol (4). The structures were elucidated by the interpretation of their spectral data. The total methanol extract ...
Senchenkova Sof'ya N SN N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, - - 2014
Capsular polysaccharide was isolated by the phenol-water extraction of Acinetobacter baumannii ACICU cells and studied by sugar analysis, partial acid hydrolysis, and 1D and 2D (1)H and (13)C NMR spectroscopy. The polysaccharide was found to contain 5,7-diacetamido-3,5,7,9-tetradeoxy-l-glycero-l-manno-non-2-ulosonic or di-N-acetylpseudaminic acid (Pse5Ac7Ac), and the following structure of the branched tetrasaccharide repeating ...
Rytel E E Department of Food Storage and Technology, Wrocław University of Environmental and Life Science, Chełmońskiego 37/41, 51-630 Wrocław, Poland. Electronic address: - - 2014
The purpose of the research was to examine the effect of the laboratory production of dried potato dice on the content of phenolic compounds in one yellow-fleshed potato variety and four blue-fleshed potatoes varieties. Coloured-flesh potato varieties were characterised by about three times higher amount of total phenolic content than ...
Vigneshkumar Balasubramanian B Department of Biotechnology, Alagappa University, Science Campus, Karaikudi, 630004, Tamil Nadu, - - 2014
Lipopolysaccharide (LPS) is the main surface constituent of Gram-negative bacteria. Lipid A, the hydrophobic moiety, outer monolayer of the outer cell membrane forms the major component of LPS. Immunogenic Lipid A is recognized by the innate immune system through the TLR 4/MD-2 complex. Pseudomonas aeruginosa PAO1, a Gram-negative bacterium is ...
Böttcher Christoph C 1 Leibniz Institute of Plant - - 2014
Indolic secondary metabolites play an important role in pathogen defence in cruciferous plants. In Arabidopsis thaliana, in addition to the characteristic phytoalexin camalexin, derivatives of indole-3-carbaldehyde (ICHO) and indole-3-carboxylic acid (ICOOH) are synthesized from tryptophan via the intermediates indole-3-acetaldoxime (IAOx) and indole-3-acetonitrile (IAN). Based on feeding experiments combined with nontargeted ...
Murza Alexandre A Department of Pharmacology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, QC, Canada; Institut de Pharmacologie de Sherbrooke, Université de Sherbrooke, Sherbrooke, QC, - - 2014
Apelin is the endogenous ligand of APJ, which belongs to the superfamily of G protein-coupled receptors. In recent years, the apelin/APJ system has been detected in many tissues and emerges as a promising target for the treatment of various pathophysiological conditions. Pyr1-apelin-13 is the major isoform of apelin in human ...
Matsnev Andrej V AV Department of Chemistry, Advanced Materials Research Laboratory, Clemson University , 91 Technology Drive, Anderson, South Carolina 29625, United - - 2014
Three novel, easily scalable routes for the synthesis of pentafluorosulfanyldifluoroacetic acid, SF5CF2C(O)OH, are described. Reactions of its acid chloride with amines and alcohols led to a small library of 15 amides and five esters, respectively. The reaction of the acid chloride with phenylmagnesium bromide gave the corresponding acetophenone. Pentafluorosulfanyldifluoroacetonitrile was ...
Poole Thomas H - - 2014
Protein sulfenic acids are formed by the reaction of biologically relevant reactive oxygen species with protein thiols. Sulfenic acid formation modulates the function of enzymes and transcription factors either directly or through the subsequent formation of protein disulfide bonds. Identifying the site, timing, and conditions of protein sulfenic acid formation ...
Lindgren J K JK University of Nebraska Medical Center, Departments of Pathology and - - 2014
Allelic replacement mutants were constructed within arginine deiminase (arcA1 and arcA2) to assess the function of the arginine deiminase pathway (ADI) in organic acid resistance and biofilm formation of Staphylococcus epidermidis 1457. A growth-dependent acidification assay (pH ∼5.0-5.2) determined that 1457 devoid of arginine deiminase activity (1457 ΔADI) was significantly ...
Holland Aleicia A School of Medical and Applied Sciences, Centre for Environmental Management, Central Queensland University, Rockhampton, Queensland, 4702, Australia, - - 2014
Differences relating to the ability of various types of humic substances (HS) to influence toxicity of pollutants have been reported in the literature, but there still remains a gap in understanding whether various HS will have the same influence on the toxicity of acid mine drainage (AMD). This study investigated ...
Mita Tsuyoshi T Faculty of Pharmaceutical Sciences, Hokkaido University , Sapporo 060-0812, - - 2014
In the presence of three readily available chemicals, Mn powder, BF3·OEt2, and LiCl, N-acyl-N,O-acetals were successfully converted into the corresponding α-amino acids (arylglycine derivatives) under 1 atm of a CO2 atmosphere in high yields. The LiCl additive is necessary in order to increase the solubility and the nucleophilicity of an ...
Tan Li L Graduate School of Science and Technology, Kumamoto University, 2-39-1 Kurokami Chuo-ku, Kumamoto, Kumamoto, 860-8555, - - 2014
Distilled grain waste eluted from Chinese spirit making is rich in carbohydrates, and could potentially serve as feedstock for the production of bio-fuel ethanol. Our study evaluated two types of saccharification methods that convert distilled grain waste to monosaccharides: enzymatic saccharification and concentrated H2SO4 saccharification. Results showed that enzymatic saccharification ...
Qiu Shiran - - 2014
Phenoxy acid herbicides are important groundwater contaminants. Stable isotope analysis and enantiomer analysis are well-recognized approaches for assessing in situ biodegradation in the field. In an aerobic degradation survey with six phenoxyacetic acid and three phenoxypropionic acid degrading bacteria we measured (a) carbon isotope fractionation of the herbicides MCPA (4-chloro-2-methylphenoxyacetic ...
Levy Evgeniya E Department of Applied Physics, The Hebrew University of Jerusalem, Givat Ram, Jerusalem 91904, - - 2014
In this paper, the fourth one of our series on the dielectric spectrum symmetrical broadening of water, we consider amino acid (AA) aqueous solutions. The developed 3D-trajectory is applied here to the variety of zwitterion amino acids representing both the hydrophobic and hydrophilic nature of their residues. The dipole moment ...
Choi Sun-A SA Biomass and Waste Energy Laboratory, Korea Institute of Energy Research, Daejeon 305-343, Republic of Korea; Department of Chemical & Biological Engineering, Korea University, Seoul 136-701, Republic of - - 2014
In this study, acid-catalyzed hot-water extraction of docosahexaenoic acid (DHA)-rich lipids from Aurantiochytrium sp. was performed, and its yield-enhancing effects were investigated. The total fatty acid content of the Aurantiochytrium sp. was 482.5mg/g cell, of which 141.7mg/g cell (29.4% of total fatty acids) was DHA. The lipid-extraction yield by acid-catalyzed ...
Dareioti Margarita Andreas MA Chemical Engineering Department, University of Patras, 1 Karatheodori str., University Campus, 26500 Patras, - - 2014
The aim of this study was to investigate the impact of pH on the production of bio-hydrogen and end-products from a mixture of olive mill wastewater, cheese whey and liquid cow manure (with a ratio of 55:40:5, v/v/v). Batch experiments were performed under mesophilic conditions (37°C) at a range of ...
Jamsazzadeh Kermani Zahra Z Laboratory of Food Technology, Leuven Food Science and Nutrition Research Centre (LFoRCe), Department of Microbial and Molecular Systems (M(2)S), KU Leuven, Kasteelpark Arenberg 22, Box 2457, 3001 Leuven (Heverlee), - - 2014
The objective of this research was to evaluate whether mango peel is a potential source of functional cell wall polymers. To reach this objective, the native pectin polymers (NPP) extracted as alcohol insoluble residue from mango peel, were characterised in terms of uronic acid content, degree of methoxylation, neutral sugar ...
Tsuda Takeo - - 2014
L-amino acid ligase (Lal) catalyzes the formation of a dipeptide from two L-amino acids in an ATP-dependent manner and belongs to the ATP-grasp superfamily. Bacillus subtilis YwfE, the first identified Lal, produces the dipeptide antibiotic bacilysin, which consists of L-Ala and L-anticapsin. Its substrate specificity is restricted to smaller amino ...
García-Sánchez Edgar E Instituto de Investigaciones Químico Biológicas, Universidad Michoacana de San Nicolás de Hidalgo , Ciudad Universitaria, Morelia, Michoacán 58030, - - 2014
Chemical investigation of the hexanes extracts of Ageratina jocotepecana afforded (-)-(5S,9S,10S,13S)-labd-7-en-15-oic acid (1), methyl (-)-(5S,9S,10S,13S)-labd-7-en-15-oate (2), (+)-(5S,8R,9R,10S,13R)-8-hydroxylabdan-15-oic acid (3), and (-)-(5S,9S,10S,13Z)-labda-7,13-dien-15-oic acid (5). The coexistence of (13R)- and (13S)-labdanes in this member of the Asteraceae family was demonstrated by vibration circular dichroism measurements of ester 2 and methyl (+)-(5S,8R,9R,10S,13R)-8-hydroxylabdan-15-oate (4) ...
Dueñas-Sánchez Rafael R Departamento de Genética, Facultad de Biología, Universidad de Sevilla, Apartado 1095, E-41080, Sevilla, Spain. Electronic address: - - 2014
2-Phenylethanol (PEA), an important alcohol derived from phenylalanine, is involved in aroma and flavour of bakers' products. Four spontaneous mutants of an industrial bakers' yeast, V1 strain, were isolated for their resistance to p-fluoro-DL-phenylalanine (PFP), a toxic analogue of L-phenylalanine. Mutants overproduced this amino acid and showed variations in their ...
Ermacora Alessia A Unilever R&D Vlaardingen, Vlaardingen, The Netherlands; Technical University of Berlin, Berlin, - - 2014
The toxicological relevance and widespread occurrence of fatty acid esters of 2-chloropropane-1,3-diol (2-MCPD) and 3-chloropropane-1,2-diol (3-MCPD) in refined oils and fats have recently triggered an interest in the mechanism of formation and decomposition of these contaminants during oil processing. In this work, the effect of the main precursors, namely acylglycerols ...
Krishna Yarkali Y Medicinal and Process Chemistry Division and ‡Centre for Nuclear Magnetic Resonance, SAIF, CSIR-Central Drug Research Institute , Lucknow, Uttar Pradesh 226031, - - 2014
Described here is the design, synthesis, and conformational analysis of cyclic tetrapeptides (CTPs) with α3γ architecture containing a furan-based locked Z-vinylogous amino acid (Vaa). This unnatural amino acid locks into a γ-turn that induces type IαRS-turn in the CTPs. Stabilized by a 13-membered intramolecular H-bond, these CTPs show robust conformation ...
Ruiz Antonieta - - 2014
Calafate (Berberis microphylla G. Forst) is an edible wild berry growing in South Patagonia that is very rich in anthocyanins and hydroxycinnamic acid derivatives. Calafate contains unusual phenolic compounds compared to other berries, like anthocyanidin dihexosides, different to the common 3,5-diglucosides, and isomeric esters of caffeic acid with hexaric acids. ...
Song Mingming M School of Environmental Science and Engineering, Shandong University, 27 Shanda Nan Road, Jinan 250100, - - 2014
The selection of the right strains is of fundamental important to the success of the algae-based oil industry. From the six newly isolated microalgae strains tested for growth, fatty acid methyl ester (FAME) profiles and biodiesel properties, Scenedesmus SDEC-8, with favorable C16:0 fatty acids (73.43%), showed the best combined results. ...
Ozkan Gülcan G Department of Food Engineering, Faculty of Engineering, University of Süleyman Demirel, 32000, Isparta, - - 2014
Caffeic acid, rosmarinic acid, rutin, apigenin 7-O-glucoside, apigenin, and acesetin were the main phenolic compounds of Origanum onites extracts in all applications. While acesetin contents ranged from 133.59 mg/100 g (U1) to 437.25 mg/100 g (S3), rosmarinic acid changed between 215.94 mg/100 g (U4) and 1120.56 mg/100 g (S2) in Origanum vulgare L. subsp. hirtum (Link) Ietsw. Both ...
Fan Senqing S School of Chemical Engineering, Sichuan University, 610065 Chengdu, - - 2014
The secondary metabolites accumulated in a pervaporation membrane bioreactor during ethanol fermentation were mostly composed of acetic acid, lactic acid, propionic acid, citric acid, succinic acid and glycerol. The inhibition effect of these compounds at a broad concentration range was studied through ethanol fermentation by Saccharomyces cerevisiae. An increasing concentration ...
Abiodun O A OA Department of Food Science and Technology, Osun State Polytechnic, P.M.B. 301, Iree, Osun State, Nigeria. Electronic address: - - 2014
Nutritional quality and essential oil compositions of Thaumatococcus danielli (Benn.) tissue and seed were determined. Oil was extracted from the seed using standard methods while the fatty acids of the oil, chemical and anti-nutritional properties of defatted seed flour were determined. Total fat yield of the seed flour was 12.20%. ...
Passos Cláudia P CP QOPNA, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal. Electronic address: - - 2014
Instant coffee was prepared and fractionated into higher (>100kDa), medium (5-10, 10-30, 30-100kDa) and lower (1-5, <1kDa) molecular weight fractions. Sugars and linkage composition characteristics of arabinogalactans and galactomannans were recovered in all fractions. Also, amino acid analysis performed after hydrolysis showed similar compositions in all fractions. On the contrary, ...
Wu Xiao-Peng XP a College of Pharmaceutical Science, Zhejiang Chinese Medical University , Hangzhou 310053 , - - 2014
A new ursane-type triterpene, cymosic acid (1) together with two known compounds, 3β,19α-dihydroxy-2-oxo-12-ursen-28-oic acid (2) and 2α,19α-dihydroxy-3-oxo-12-ursen-28-oic acid (3), were isolated from Rosa cymosa Tratt. The structure of compound 1 was elucidated by analyzing its (1)H and (13)C NMR, (1)H-(1)H COSY, HSQC, HMBC, NOESY, and HR-ESI-MS values. The three compounds ...
Uchida Yuki Y Department of Life Science and Biotechnology, Faculty of Chemistry, Materials and Bioengineering, Kansai University, 3-3-35 Yamate-Cho, Suita, Osaka-Fu, 564-8680, - - 2014
We successfully cloned a novel branched-chain amino acid aminotransferase (Ts-BcAT; EC 2.6.1.42) gene from the Thermococcus sp. CKU-1 genome and expressed it in the soluble fraction of Escherichia coli Rosetta (DE3) cells. Ts-BcAT is a homodimer with an apparent molecular mass of approximately 92 kDa. The primary structure of Ts-BcAT showed ...
Sidorov Roman A RA Laboratory of Lipid Metabolism, K. A. Timiryazev Institute of Plant Physiology, Russian Academy of Sciences, Botanicheskaya ul. 35, Moscow 127276, Russia, (phone: +7-499-9778355; fax: - - 2014
The dynamics of the fatty-acid (FA) composition of neutral acylglycerols (NAGs) composed of 1,2,3-triacyl-sn-glycerols (TAGs) and 3-acetyl-1,2-diacyl-sn-glycerols (acDAGs) was determined in the fruit seeds and arils of three Euonymus L. species at three stages of their maturity. The NAG composition comprised 29 FAs, linoleic, oleic, palmitic, and α-linolenic acids being ...
de Los Reyes Carolina C Departamento de Química Orgánica, Facultad de Ciencias del Mar y Ambientales, Universidad de Cádiz, 11510 Puerto Real, Cádiz, - - 2014
The chemical study of the microalgae Chlamydomonas debaryana and Nannochloropsis gaditana has led to the isolation of oxylipins. The samples of C. debaryana have yielded the compounds (4Z,7Z,9E,11S,13Z)-11-hydroxyhexadeca-4,7,9,13-tetraenoic acid (1), (4Z,7E,9E,13Z)-11-hydroxyhexadeca-4,7,9,13-tetraenoic acid (2), (4Z,6E,10Z,13Z)-8-hydroxyhexadeca-4,6,10,13-tetraenoic acid (3), (4Z,8E,10Z,13Z)-7-hydroxyhexadeca-4,8,10,13-tetraenoic acid (4), and (5E,7Z,10Z,13Z)-4-hydroxyhexadeca-5,7,10,13-tetraenoic acid (5), which are derived from the fatty acid ...
Nedumaran D - - 2014
Zr mesoporous materials with different Si/Zr ratio were synthesized by the surfactant-templated method involving cetyl trimethyl ammonium bromide (CTAB) as template and tetraethyl ortho silicate (TEOS) as organic source of silicon. The synthesized materials were labeled as SiZrMx (where x is Si/Zr = 10, 20 and 30). The BET analysis ...
Winiecka I - - 2014
Six novel potential renin inhibitors have been designed and synthesized. All these inhibitors contained an unnatural aminoalkanoyl moiety at the central position P1- P1' of the molecule, which is attacked by renin. The moiety consists of pseudodipeptidic units, transition state analogues of a natural dipeptide of the parent substance: 4-amino-3-hydroxybutanoic ...
Lima Marcos Dos Santos Mdos S Instituto Federal do Sertão Pernambucano, Campus Petrolina, Coordenação de Tecnologia de Alimentos, Jardim São Paulo - 56314-520, Petrolina, PE, Brazil. Electronic address: - - 2014
The phenolic compounds, organic acids and the antioxidant activity were determined for grape juice samples from new Brazilian varieties grown in the Sub-middle São Francisco Valley in the Northeast Region of Brazil. The results showed that the Brazilian grape juices have high antioxidant activity, which was significantly correlated with the ...
Deskins Caitlin E - - 2014
The acetone bark extracts of three species of Lonchocarpus from Monteverde, Costa Rica, L. atropurpureus, L. oliganthus, and L. monteviridis, were screened for antibacterial, cytotoxic, and antioxidant activities. L. orotinus extract was antibacterial against Bacillus cereus (MIC = 39 microg/mL), while L. monteviridis exhibited the most antioxidant activity. None of ...
Lyudinina Alexandra Y AY Institute of Physiology, Ural Branch, Russian Academy of Sciences, Syktyvkar, Russia. - - 2014
The goal of this study was to examine the fatty acid (FA) composition of the total plasma lipids of the native inhabitants of the Russian European North, taking into consideration the differences in lifestyles and nutritional habits as well as the interrelationship between the plasma FA profile and nutrition. In ...
Armstrong Alan - - 2014
The scope of the NCS mediated amination/[2,3]-sigmatropic rearrangement of enantioenriched allylic selenides has been expanded to provide access to three new product classes. Use of N-protected amino acid amides provides a novel strategy for accessing peptide chains containing unnatural vinyl glycine amino acid residues. Also reported is the use of ...
Li Weina W Department of Engineering, Aarhus University, Aarhus, - - 2014
To maintain biological functions, thousands of different reactions take place in human body at physiological pH (7.0) and mild conditions, which is associated with health and disease. Therefore, to examine the catalytic function of the intrinsically occurring molecules, such as amino acids at neutral pH, is of fundamental interests. Natural ...
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