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Wendisch Volker F VF Chair of Genetics of Prokaryotes, Faculty of Biology & CeBiTec, Bielefeld University, Germany. Electronic address: - - 2014
Amino acids are produced at the multi-million-ton-scale with fermentative production of l-glutamate and l-lysine alone being estimated to amount to more than five million tons in the year 2013. Metabolic engineering constantly improves productivities of amino acid producing strains, mainly Corynebacterium glutamicum and Escherichia coli strains. Classical mutagenesis and screening ...
Nagai Junya J Department of Pharmaceutics and Therapeutics, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan; Laboratory of Pharmaceutics, Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan. Electronic address: - - 2014
Recently, we found that albumin overload induces expression of the transcription factor hypoxia-inducible factor-1α (HIF-1α) protein and several HIF-1 target genes in human renal proximal tubular epithelial cell line HK-2. In this study, the role of albumin-bound fatty acids in the albumin-induced HIF-1 activation was studied. The enhancing effect of ...
Xue Yong Y Department of Applied Science, University of Arkansas at Little Rock, Little Rock, AR 72204; - - 2014
p-Coumaric acid is the precursor of phenylpropanoids, which are plant secondary metabolites that are beneficial to human health. Tyrosine ammonia lyase catalyzes the production of p-coumaric acid from tyrosine. Because of their photosynthetic ability and biosynthetic versatility, cyanobacteria are promising candidates for the production of certain plant metabolites, including phenylpropanoids. ...
Meng Jingjing J State Key Laboratory of Loess and Quaternary Geology, Institute of Earth Environment, Chinese Academy of Sciences, Xi'an 710075, China; University of Chinese Academy of Sciences, Beijing 100049, - - 2014
PM10 aerosols from the summit of Mt. Hua (2060ma.s.l) in central China during the winter and summer of 2009 were analyzed for dicarboxylic acids, ketocarboxylic acids and α-dicarbonyls. Molecular composition of dicarboxylic acids (C2-C11) in the free tropospheric aerosols reveals that oxalic acid (C2, 399±261ngm(-3) in winter and 522±261ngm(-3) in ...
Zhang Liangliang L a Institute of Chemical Industry of Forest Products, CAF , Nanjing 210042 , Jiangsu Province , P.R. - - 2014
The infructescence of Platycarya strobilacea Sieb. et Zucc is a well-known traditional medicine in China, Japan and Korea. The infructescence of P. strobilacea Sieb. et Zucc is a rich source of ellagitannins that are composed of ellagic acid (EA) and gallic acid, linked to a sugar moiety. The aim of ...
Malumba Paul P University of Liège, Gembloux Agro-Bio Tech, Laboratory of Food Process Engineering, Belgium; University of Kinshasa, Agricultural Faculty, Department of Chemistry and Agricultural Industry, Democratic Republic of the Congo. Electronic address: - - 2015
The chemical characteristics of co-products recovered during a laboratory-scale wet milling procedure as well as that of whole corn flour were characterised and their digestibility and fermentability value determined using a 2 steps in vitro digestibility and fermentation model of the pig digestive tract. Five co-products differing in their chemical ...
Montrieux Elly E Laboratory of Microbiology, Parasitology and Hygiene (LMPH), Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, Antwerp University, Antwerp, - - 2014
The search for new therapeutic agents from natural sources has been a constant for the treatment of diseases such as leishmaniasis. Herein, in vitro and in vivo pharmacological activities of pure major phenolic constituents (caffeic acid, chlorogenic acid, ferulic acid, quercetin, and rosmarinic acid) from Pluchea carolinensis against Leishmania amazonensis ...
Yun Hyun-Shik HS Department of Environmental Engineering, Yonsei University, Wonju, 220-710, South - - 2014
Microalgae were selected and isolated from acid mine drainage in order to find microalgae species which could be cultivated in low pH condition. In the present investigation, 30 microalgae were isolated from ten locations of acid mine drainage in South Korea. Four microalgae were selected based on their growth rate, ...
McMahon D J DJ Western Dairy Center, Utah State University, Logan 84322. Electronic address: - - 2014
Sodium reduction in cheese can assist in reducing overall dietary Na intake, yet saltiness is an important aspect of cheese flavor. Our objective was to evaluate the effect of partial substitution of Na with K on survival of lactic acid bacteria (LAB) and nonstarter LAB (NSLAB), pH, organic acid production, ...
Li Wei W College of Forest Resources and Environment, Nanjing Forestry University, Longpan Road 159, Nanjing 210037, China; Key Laboratory of Pollution Processes and Environmental Criteria (Nankai University), Ministry of Education, Tianjin 300071, China. Electronic address: - - 2014
This study examined the degradation of the widely used antineoplastic drug 5-fluorouracil (5FU) by chlorine and bromine. 5FU was determined to interact readily with free chlorine and bromine but was stable in the presence of chloramine. The removal of 5FU followed a second-order kinetic pattern. Apparent rates (kapp) of 5FU ...
Tlili Chaker C Department of Chemical and Environmental Engineering, University of California, Riverside, CA 92521, USA. Electronic address: - - 2014
In this work, a non-enzymatic chemiresistive sugar sensor has been developed by combining a synthetic receptor with aligned single-walled carbon nanotubes (SWNTs) device. Briefly, boronic acid as a multivalent sugar receptor was immobilized on carbon nanotubes through amide bond formation. The interaction between three common sugars (d-glucose, d-fructose and sucrose) ...
Apel Cécile C Centre de Recherche de Gif, Institut de Chimie des Substances Naturelles (ICSN), CNRS , 1 av de la Terrasse, 91198 Gif-sur-Yvette Cedex, - - 2014
A rapid screening by (1)H and (1)H-(13)C HSQC NMR spectroscopy of EtOAc extracts of Endiandra and Beilschmiedia species allowed the selection of Beilschmiedia ferruginea leaves and flowers extract for a chemical investigation, leading to the isolation of 11 new tetracyclic endiandric acid analogues, named ferrugineic acids A-K (1-11). Their structures ...
Schunder Eva E RKI Berlin, - - 2014
Legionella pneumophila survives and replicates within a Legionella containing vacuole (LCV) of amoebae and macrophages. Less is known about the carbon metabolism of the bacteria within the LCV. We have now analyzed the transfer and usage of amino acids from the natural host organism Acanthamoeba castellanii to L. pneumophila under ...
Kubo Ryosuke R Department of Natural Resources, Graduate School of Global Environmental Studies, Kyoto University, Yoshida-Honmachi, Kyoto 606-8501, - - 2014
We investigated yeast strains used in Cameroonian microbreweries, and identified a Saccharomyces cerevisiae strain (OCY3) with an excellent capacity for alcoholic fermentation. OCY3 showed higher tolerance to lactic acid and better fermentation performance under acidic conditions than a representative Japanese sake yeast, Kyokai No. 7, and a wine yeast, EC1118.
Li Heyu H a College of Chemistry, Chemical Engineering and Biotechnology, Donghua University , Shanghai 201620 , - - 2014
Poly(l-lactic acid-co-ε-caprolactone) (P(LLA-CL)) is a kind of copolymer polymerized from lactic acid and ε-caprolactone. Electrospun P(LLA-CL) nanofibers have good biocompatibility, biodegradability, and mechanical property. However, this type of nanofibers will produce acid groups during the degradation, so that, the pH value of the environment will decrease and result in tissue ...
Oba Takahiro T Biotechnology and Food Research Institute, Fukuoka Industrial Technology Center, 1465-5 Aikawa-machi, Kurume, Fukuoka, 839-0861, - - 2014
Research on the relationship between mitochondrial membrane potential and fermentation profile is being intensely pursued because of the potential for developing advanced fermentation technologies. In the present study, we isolated naturally occurring strains of yeast from sake mash that produce high levels of malic acid and demonstrate that variations in ...
Hashimoto Makoto M Iwate Medical University, - - 2014
The type III polyketide synthases (PKSs) from fungi produce a variety of secondary metabolites including pyrones, resorcinols, and resorcylic acids. We previously reported that CsyB from Aspergillus oryzae forms α-pyrone csypyrone B compounds when expressed in A. oryzae. Feeding experiments of labeled acetates indicated that a fatty acyl starter is ...
Subramanian Mohan Raj MR Center for Bioprocessing Research and Development, South Dakota School of Mines and Technology, Rapid City, SD, 57701, - - 2014
Lactic acid is an intermediate-volume specialty chemical for a wide range of food and industrial applications such as pharmaceuticals, cosmetics and chemical syntheses. Although lactic acid production has been well documented, improved production parameters that lead to reduced production costs are always of interest in industrial developments. In this study, ...
Fülöpová Veronika - - 2014
The solid-phase synthesis of tri-substituted 2,5-dihydrobenzo[f][1,2,5]thiadiazepine 1,1-dioxides is reported. Acyclic polymer-supported intermediates were prepared using commercially available building blocks: Fmoc-amino acids, 2-nitrobenzenesulfonyl chlorides, and bromoketones. The acyclic precursors underwent acid-mediated release from the resin followed by cyclization in solution.
Lai Jingjing - - 2014
Amyloid formation is now considered as a universal and intrinsic property of all proteins, irrespective of their sequences. Therefore, it is interesting to see whether random copolymers of amino acids can also form amyloid aggregates. Here we use a copolymer of 4 amino acids, mimicking the clinically-used drug Glatiramer, and ...
Stojković Dejan D University of Belgrade, Department of Plant Physiology, Institute for Biological Research "Siniša Stanković", Bulevar Despota Stefana 142, 11000 Belgrade, - - 2014
Agaricus bisporus (J. E. Lange) Emil J. Imbach and Agaricus brasiliensis Wasser, M. Didukh, Amazonas & Stamets are edible mushrooms. We chemically characterized these mushrooms for nutritional value, hydrophilic and lipophilic compounds. The antioxidant and antimicrobial activities of methanolic and ethanolic extracts were assessed. Hepatotoxicity was also evaluated. The ethanolic ...
Wu Hui H Department of Bioengineering, Rice University, Houston, - - 2014
Free fatty acids (FFAs) can be used as precursors for the production of biofuels or chemicals. Different composition of FFAs will be useful for further modification of the biofuel/biochemical quality. Microbial biosynthesis of even chain free fatty acids (FFAs) can be achieved by introducing an acyl-acyl carrier protein thioesterase gene ...
Park Ji-Yeon JY Biomass and Waste Energy Laboratory, Korea Institute of Energy Research, Daejeon 305-343, Republic of Korea. Electronic address: - - 2014
Microalgal lipid with a high free fatty acid (FFA) content was directly extracted from Chlorella vulgaris, using SDBS, in an acid-catalyzed hot-water extraction process. The total fatty acid content of C. vulgaris was 296.0mg/g cell. Under the 1.0% sulfuric acid, 0.4% SDBS conditions, the FFA content of the lipid increased ...
Xiao Han H State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for Research and Development of Fine Chemicals, Guizhou University, Guiyang 550025, PR China; School of Chemistry and Environmental Science, Guizhou Minzu University, Guiyang 550025, PR - - 2014
Here, a series of β-amino acid ester derivatives containing quinazoline and benzothiazoles was synthesized and evaluated for anti-tobacco mosaic virus (TMV) activity. The compounds 3n, 3o, 3p and 3q showed good antiviral activity against TMV at a concentration of 500μg/mL, with curative rates of 55.55%, 52.32%, 52.77% and 50.91%, respectively, ...
Song Zhimei Z Department of Pharmaceutical Engineering, School of Biological Science and Technology, University of Jinan, 336 Nanxinzhuang Xilu, Jinan, Shandong Province 250022, PR - - 2014
In this study, a novel linolenic acid-modified poly(ethylene glycol)-b-poly(ϵ-caprolactone) copolymer was prepared through radical addition, ring-opening polymerization, and N-acylation reactions. Its structure was characterized by (1)H NMR and GPC. Micelles were developed by thin-film hydration and used as a delivery system for curcumin with high drug loading capacity of 12.80% ...
Tian Li-Wen LW Eskitis Institute, Griffith University, Brisbane, QLD 4111, - - 2014
High throughput screening of a pre-fractionated natural product library identified 11 active fractions showing ApoE modulation activity. Mass-directed fractionation of one active crude extract from the Australian marine sponge Callyspongia sp. resulted in the isolation of 13 metabolites, including three new bromotyrosine derivatives, callyspongic acid (1), 3,5-dibromo-4-methoxyphenylpyruvic acid (2), N-acetyl-3-bromo-4-hydroxylphenylethamine ...
Han Hyoung Soon - - 2014
A simple method has adapted to prepare MWCNT grafted Poly(lactic acid) (MWCNT-g-PLA) by intercalative polymerization of poly(lactic acid) in the presence of multi-wall carbon nanotubes (MWCNT) functionalized with hydroxyl groups. The functionalized MWCNT has obtained from the treatment of methylene diphenyl diisocyanate (MDI) with MWCNT, and then the reaction with ...
de Godoy M R C MR Department of Animal Sciences - - 2014
The objective of this research was to measure in vitro hydrolytic digestion, glycemic and insulinemic responses in dogs, and true ME (TMEn) content of select soluble corn fibers (SCF) in roosters. The first generation (G1) SCF included hydrochloric acid-treated corn syrup (G1-CS-HCl), an SCF with an increased total dietary fiber ...
Thiruvengadam M M Konkuk University Department of Applied Bioscience, College of Life and Environmental Science Seoul 143 701 South - - 2014
Phenolic contents and antioxidant capacities from different solvent extracts (petroleum ether, ethyl acetate, methanol, butanol and water) of Aster scaber leaf were investigated. Antioxidant activity was evaluated by three different methods, namely DPPH radical scavenging activity, reducing power assay and phosphomolybdenum activity. A total of twenty-three polyphenolic compounds were identified ...
Innocente Adrine Maria AM Laboratório de Fitoquímica, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Av. Ipiranga, 2752, Porto Alegre, RS, - - 2014
Trichomonas vaginalis is a flagellated parasite that causes trichomonosis, the most common non-viral sexually transmitted disease (STD) in the world. Worryingly, trichomonosis is associated to increased transmission of HIV. Due to high frequency of the infection during pregnancy and the development of metronidazole-resistant isolates, therapeutic alternatives to 5-nitroimidazole are being ...
Komatsu Reina R Department of Biological Science and Technology, Tokyo University of Science, 6-3-1 Niijuku, Katsushika-ku, Tokyo, 125-8585, - - 2014
Stereochemical assignment of amino acids and corresponding codons or anticodons has not been successful so far. Here, we focused on proline and GGG (anticodon of tRNA(Pro)) and investigated their mutual interaction. Circular dichroism spectroscopy revealed that guanosine nucleotides (GG, GGG) formed G-quartet structures. The structures were destroyed by adding high ...
Lee In-Kyu IK Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, - - 2014
The pyruvate dehydrogenase complex (PDC) is an emerging target for the treatment of metabolic syndrome. To maintain a steady-state concentration of adenosine triphosphate during the feed-fast cycle, cells require efficient utilization of fatty acid and glucose, which is controlled by the PDC. The PDC converts pyruvate, coenzyme A (CoA), and ...
Sekito Takayuki T a Laboratory of Molecular Physiology and Genetics, Faculty of Agriculture , Ehime University , Matsuyama , - - 2014
Basic amino acids (lysine, histidine and arginine) accumulated in Saccharomyces cerevisiae vacuoles should be mobilized to cytosolic nitrogen metabolism under starvation. We found that the decrease of vacuolar basic amino acids in response to nitrogen starvation was impaired by the deletion of AVT4 gene encoding a vacuolar transporter. In addition, ...
Pyo Young-Hee YH Department of Food and Nutrition, Sungshin Women's University, Seoul 142-732, - - 2014
Four Korean kernel fruit (apple, pear, persimmon, and mandarin orange) juices were obtained by household processing techniques (i.e., blending, juicing). Whole and flesh fractions of each fruit were extracted by a blender or a juicer and then examined for phytochemical content (i.e., organic acids, polyphenol compounds). The antioxidant capacity of ...
Krzyśko-Łupicka Teresa T Department of Biotechnology and Molecular Biology, Faculty of Natural and Technical Sciences, University of Opole, Kard. B. Kominka 6a, 45-035, Opole, - - 2014
This study was aimed at investigating the physicochemical and microbiological changes that took place during the ageing process of spent bleaching earth in the presence of autochthonous microorganisms. Research material included fresh spent bleaching earth (SBE0) and the same material after 3 years of storage at the constant temperature of 20 °C, ...
Harman Christopher C Norwegian Institute for Water Research, Oslo, - - 2014
Polar organic chemical integrative samplers (POCIS) were deployed in the vicinity of an offshore oil installation and analysed for naphthenic acids (NA). POCIS accumulated a range of mono to tetracyclic NA, with different degrees of alkylation, with monocyclic acids being the most abundant. POCIS or similar polar samplers may currently ...
Wang Jian J Department of Pharmaceutics, School of Pharmacy, Key Laboratory of Smart Drug Delivery, Ministry of Education, Fudan University, 826 Zhangheng Road, Shanghai, 201203, - - 2014
Viscoelasticity is a useful parameter for characterizing the intrinsic properties of the cross-linked polyacrylate hydrogel used in cataplasm bases. The aim of this study was to investigate the effects of various formulation parameters on the rheological characteristics of polyacrylate hydrogel. The hydrogel layers were formed using a partially neutralized polyacrylate ...
Tatsumi Kenta K Department of Energy and Hydrocarbon Chemistry, Graduate School of Engineering, Kyoto University, Kyoto 615-8510, Japan. tfuji@scl.kyoto-u.ac.jp - - 2014
Palladium-catalyzed formal arylacylation of allenes using acid chlorides and arylboronic acids has been achieved. The reaction afforded the corresponding α,β-unsaturated ketones regio- and stereoselectively.
Choi Jong-Il JI Department of Biotechnology and Bioengineering, Chonnam National University, Gwangju, 500-757, South Korea, - - 2014
In this study, a high lipid-accumulating mutant strain of the microalgae Scenedesmus dimorphus was developed via radiation breeding. To induce mutant strain, S. dimorphus was gamma-irradiated at doses from 100 to 800 Gy, and then a mutant (Sd-Pm210) with 25 % increased lipid content was selected using Nile red staining methodology. Sd-Pm210 ...
Xiong Xunyu X Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, College of Chemistry and Materials Science, Northwest University, Xi'an, 710069, China; College of Chemistry & Chemical Engineering, Xi'an Shiyou University, Xi'an 710065, - - 2014
We have developed a rapid method that allows us to characterize the binding interaction of sulfobutylether-β-cyclodextrin (SBE-β-CD) with five therapeutically important phenolic acids: ferulic acid, caffeic acid, gallic acid, protocatechuic acid and vanillic acid. The method utilizes a flow-injection chemiluminescence (FI-CL) technique that relies on the inhibition of a cyclodextrin-luminol ...
Follonier Stéphanie S University of Applied Sciences and Arts Western Switzerland Valais (HES-SO Valais-Wallis), Institute of Life Technologies, Route du Rawyl 47, 1950 Sion, - - 2014
Medium-chain-length polyhydroxyalkanoates (mcl-PHAs) are biobased and biodegradable alternatives to petrol-derived polymers, whose break-through has been prevented by high production cost. Therefore we investigated whether wastes from the food industry (9 types of fruit pomace including apricots, cherries and grapes, and waste frying oil) could replace the costly sugars and fatty ...
Moertelmaier Christoph C Karlsruhe Institute of Technology (KIT), Institute of Biology for Engineers and Biotechnology of Wastewater, Am Fasanengarten, D-76128 Karlsruhe, Germany. Electronic address: - - 2014
Volatile fatty acid (VFA) metabolism and population changes during re-start of a wet anaerobic digester for treatment of biowaste suspensions were investigated. Initially acetate and propionate accumulated. However, VFA degradation rates improved within 2weeks, reaching a balanced metabolism with constantly low VFA concentrations. The total microbial population consisted of 60% ...
Tan Jin J Tianjin Key Laboratory of Food Biotechnology, College of Biotechnology and Food Science, Tianjin University of Commerce, Tianjin 300134, People's Republic of - - 2014
Design of chemical sensor arrays that can discriminate real-world samples has been highly attractive in recent years. Herein a fluorescent indicator-displacement sensor array for discrimination of fresh fruit juices was developed. By coupling the unique high affinity of titania to electron-donating anions and the cross-reactivity of molecularly imprinted materials to ...
Badjah Hadj Ahmed A Yacine - - 2014
A simple method has been described for simultaneous determination of phenolic acids, flavonoids and other phenols contents in various natural honey samples collected from various regions of Yemen. Multiwalled carbon nanotubes were used as solid phase adsorbent for extraction of the polyphenols from honey samples. The total content of phenolic ...
Tressler Caitlin M - - 2014
(2S,4R)- and (2S,4S)-perfluoro-tert-butyl-4-hydroxyproline were synthesized (as Fmoc-, Boc-, and free amino acids) in 2-5 steps. The key step of each synthesis was a Mitsunobu reaction with perfluoro-tert-butanol, which incorporated a perfluoro-tert-butyl group, with 9 chemically equivalent fluorines. Both amino acids were incorporated in model alpha-helical and polyproline helix peptides. Each ...
Lu Jin J School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, - - 2014
Seven sesquiterpenes, including four α-cedrene type (Shellolic acid A-C, Laccishellolic acid), two R-curcumene type (Shellolic acid D-E) and Shellolic acid F were isolated from Shellac, of which six were unknown. Their structures were elucidated by HR-ESI-MS, UV, IR, 1D and 2D NMR methods. The absolute configurations were confirmed via the ...
Ye Lingzhen L Agronomy Department, Zhejiang University, Hangzhou 310029, People's Republic of - - 2014
Our previous study found that the critical protein in SE (silica eluted) proteins is BTI-CMe, and assumed that SE-ve malt for brewing may improve the haze stability in beer. In this study, we investigated the difference in gene sequence and corresponding amino acid sequence of BTI-CMe between SE+ve and SE-ve ...
Wu Chien-Hui CH Department of Food Science, National Taiwan Ocean University, No. 2, Pei-Ning Road, Keelung 202, Taiwan, R. O. - - 2014
One-step sulfuric acid saccharification of the red alga Pterocladiella capillacea was optimized and the detoxification methods of neutralization, overliming, and electrodialysis for its acid hydrolysate were evaluated for fermentability using the thermotolerant yeast Kluyveromyces marxianus. Proximate composition analysis indicated that P. capillacea was rich in carbohydrates. A significant galactose recovery ...
Haun William W Cellectis plant sciences Inc., New Brighton, MN, - - 2014
Soybean oil is high in polyunsaturated fats and is often partially hydrogenated to increase its shelf life and improve oxidative stability. The trans-fatty acids produced through hydrogenation pose a health threat. Soybean lines that are low in polyunsaturated fats were generated by introducing mutations in two fatty acid desaturase 2 ...
Yang Xufei X Department of Agricultural and Biological Engineering, University of Illinois at Urbana-Champaign, 1304 West Pennsylvania Avenue, Urbana, IL 61801, USA. Electronic address: - - 2014
Airborne particles are known to serve as a carrier of odors emanating from concentrated animal feeding operations (CAFOs). However, limited quantitative data about particle-borne odorants preclude an accurate assessment of the role of particles in odor transport. This study collected total suspended particulates (TSP) and PM10 (particles with aerodynamic diameter ...
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