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Parsons Joshua B JB Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN 38105; - - 2014
Extracellular fatty acid incorporation into the phospholipids of Staphylococcus aureus occurs via fatty acid phosphorylation. We show that fatty acid kinase (Fak) is composed of two dissociable protein subunits encoded by separate genes. FakA provides the ATP binding domain and interacts with two distinct FakB proteins to produce acyl-phosphate. The ...
Stevenson Timothy J TJ Department of Biological Sciences, College of Arts and Sciences, University of Alaska Anchorage. - - 2014
We examined the seasonal changes of the cecal microbiota of captive arctic ground squirrels (Urocitellus parryii) by measuring microbial diversity and composition, total bacterial density and viability, and short change fatty acid concentrations at four sample periods (summer, torpor, inter-bout arousal and post-hibernation. Abundance of Firmicutes was lower, whereas abundances ...
Toshima Naoko N Graduate School of Systems Life Sciences, Kyushu University, Hakozaki, Fukuoka 812-8581, Japan; Department of Biology, Faculty of Science, Kyushu University, Hakozaki, Fukuoka 812-8581, - - 2014
To understand homeostatic regulation in insects, we need to understand the mechanisms by which they respond to external stimuli to maintain the internal milieu. Our previous study showed that Drosophila melanogaster exhibit specific amino acid preferences. Here, we used the Drosophila melanogaster Genetic Reference Panel (DGRP), which is comprised of ...
Speijer D D Department of Medical Biochemistry, Academic Medical Center (AMC), UvA, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands - - 2014
Oxygen radical formation in mitochondria is an incompletely understood attribute of eukaryotic cells. Recently, a kinetic model was proposed, in which the ratio between electrons entering the respiratory chain via FADH2 or NADH determines radical formation. During glucose breakdown, the ratio is low; during fatty acid breakdown, the ratio is ...
Leppänen Hanna K HK National Institute for Health and Welfare, Department of Environmental Health, P.O.Box 95, 70701, Kuopio, - - 2014
The objectives of this study were a) to assess the determinants that affect concentrations of the bacterial cell wall components 3-hydroxy fatty acids (3-OH FAs) and muramic acid and of total viable bacteria and actinomycetes in house dust; and b) to examine the seasonal variation and reproducibility of these bacterial ...
Latha Gandla Madhavi M Department of Chemistry, Umeå University, SE-901 87 Umeå, - - 2014
The secondary walls of angiosperms contain large amounts of glucuronoxylan that is thought to be covalently linked to lignin via ester bonds between 4-O-methyl-α-d-glucuronic acid (4-O-Me-GlcA) moieties in glucuronoxylan and alcohol groups in lignin. This linkage is proposed to be hydrolysed by glucuronoyl esterases (GCEs) secreted by wood-degrading fungi. We ...
Mathieu Christoph - - 2014
Amino acid transporters are crucial for parasite survival since the cellular metabolism of parasitic protozoa depends on the uptake of exogenous amino acids. Amino acid transporters are also of high pharmacological relevance because they may mediate uptake of toxic amino acid analogs. We now show that the eflornithine transporter AAT6 ...
Elm Jonas - - 2014
We investigate the molecular interactions between the semi-volatile α -pinene oxidation product pinic acid and sulfuric acid using computational methods. The stepwise Gibb's free energies of formation have been calculated utilizing the M06-2X functional and the stability of the clusters are evaluated from the corresponding ∆G-values. The first two additions ...
Oh Sang Hoon - - 2014
Bulk-heterojunction organic solar cells (OSCs) based on poly(3-hexylthiophene) as a donor material and (6.6) phenyl-C61-butyric acid methyl ester as an acceptor material were investigated using a poly(3,4-ethylenedioxythiophene) poly(styrenesulfonate) (PEDOT:PSS) buffer layer that was modulated with acetic acid. The 1.71 x 10(-1) omega x cm resistivity of the pristine PEDOT:PSS film ...
Shah Kamal K Institute of Pharmaceutical Research, GLA University, Mathura, UP, - - 2014
Gastrosparing novel prodrugs (MAM and MAT) synthesized consisted of mefenamic acid (MA) with menthol (M) and thymol (T). Structural characterizations of synthesized esters were done by Infra red spectroscopy (IR), proton nuclear magnetic resonance (1HNMR), mass spectroscopy. After evaluation of pharmacological i.e. anti-inflammatory, analgesic and ulcerogenic activities, the preformulation studies ...
Pagadala Lakshmi Reddy LR Crop Protection Chemicals, Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500 007, - - 2014
A novel synthesis of highly substituted pyrrole-N-acetic derivatives is described through the coupling of 1,4-diketones with amino acids following Paal-Knorr's approach. These pyrrole-N-acetic acid derivatives are found to exhibit potent anti-mycobacterial activity against Mycobacterium smegmatis and Mycobacterium tuberculosis strain H37Rv. In particular, 5n, 5q &5r are found to display excellent ...
Han Li L Institute of Microbial Pharmaceuticals, College of Life and Health Sciences, Northeastern University, Shenyang 110819, P. R. China (phone/fax: - - 2014
Six new nonactic and homononactic acid derivatives, ethyl homononactate (1), ethyl nonactate (2), homononactyl homononactate (6), ethyl homononactyl nonactate (7), ethyl homononactyl homononactate (8), and ethyl nonactyl nonactate (9), as well as four known compounds, homononactic acid (3), nonactic acid (4), homononactyl nonactate (5), and bishomononactic acid (10), were isolated ...
Verma Rameshwar R G.R.Y. Institute of Pharmacy, "Vidhya Vihar" Borawan, Khargone, Madhya Pradesh, - - 2014
Wild grown European blackberry Rubus fruticosus) plants are widespread in different parts of northern countries and have been extensively used in herbal medicine. The result show that European blackberry plants are used for herbal medicinal purpose such as antimicrobial, anticancer, antidysentery, antidiabetic, antidiarrheal, and also good antioxidant. Blackberry plant (R. ...
Goderska Kamila K Faculty of Food Technology and Nutrition, Institute of Food Technology of Plant Origin, Poznan University of Life Sciences, Poznan, Poland, - - 2014
Lactobionic acid is a relatively new product derived from lactose oxidation, with high potential applications as a bioactive compound. Conducted experiments confirmed that both the time and temperature influenced the production of lactobionic acid during bioconversion of lactose using the Pseudomonas taetrolens bacteria. The study also investigated the effect of ...
Takata Yusei Y Department of Chemistry, Biotechnology, and Chemical Engineering, Graduate School of Science and Engineering, Kagoshima University, 1-21-40 Korimoto, Kagoshima, 890-0065, - - 2014
This article reports the enzymatic synthesis of dendritic amphoteric α-glucans having both glucuronic acid and glucosamine residues at the non-reducing ends by thermostable phosphorylase-catalyzed successive glucuronylation and glucosaminylation of a glucan dendrimer having α-(1 → 4)-glucan non-reducing ends using α-D-glucuronic acid 1-phosphate and α-D-glucosamine 1-phosphate as glycosyl donors, respectively. The ...
Hara Ryotaro R a Research Institute for Science and Engineering , Waseda University , Tokyo , - - 2014
We evaluated the substrate specificities of four proline cis-selective hydroxylases toward the efficient synthesis of proline derivatives. In an initial evaluation, 15 proline-related compounds were investigated as substrates. In addition to l-proline and l-pipecolinic acid, we found that 3,4-dehydro-l-proline, l-azetidine-2-carboxylic acid, cis-3-hydroxy-l-proline, and l-thioproline were also oxygenated. Subsequently, the product ...
Chen Guohua - - 2014
Suzuki-Miyaura coupling reaction was applied in the syntheses of neoglycopeptides. This work utilizes new type of glycosyl aryl boronic acid and readily accessible iodo amino acids/iodopeptides. Both carbohydrate and peptide moieties are unprotected and the final product could be isolated directly. The neoglyco amino acid and neoglycopeptide products feature an ...
Németh Krisztina K Institute of Organic Chemistry, Research Centre for Natural Sciences, Hungarian Academy of Sciences, P.O.B. 286, H-1519 Budapest, Hungary. Electronic address: - - 2014
The resolution power of permethylated 6-monoamino-6-monodeoxy-βCD (PMMABCD) - a single isomer, cationic CD derivative - developed previously for chiral analyses in capillary electrophoresis was further studied here. Dansylated amino acids (Dns-AA) were chosen as amphoteric chiral model compounds. Changes in the resolutions of Dns-AAs by varying pH and selector concentrations ...
Yao Jiangwei J St. Jude Children's Research Hospital, United - - 2014
The major phospholipid classes of the obligate intracellular bacterial parasite Chlamydia trachomatis are the same as its eukaryotic host except that they also contain chlamydial-made branched-chain fatty acids in the 2-position. Genomic analysis predicts C. trachomatis is capable of type II fatty acid synthesis (FASII). AFN-1252 was deployed as a ...
Saghyan Ashot S AS Department of Pharmaceutical Chemistry, Yerevan State University, 1 A. Manoogian Str., 0025, Yerevan, - - 2014
In this work, we report the asymmetric synthesis and characterization of an artificial amino acid based on triazolyl-thione L-alanine, which was modified with a thiophenyl-substituted moiety, as well as in vitro studies of its nucleic acid-binding ability. We found, by dynamic light scattering studies, that the synthetic amino acid was ...
Xu Xiaoxue X Department of Mycology, Shandong Agricultural University, Taian, Shandong 271018, - - 2014
Fungal species present in extreme low pH environments are expected to have adapted for tolerance to high H(+) concentrations. However, their adaptability mechanism is unclear. In this study, we isolated an acid-tolerant strain of Penicillium funiculosum, which can grow actively at pH 1.0 and thrived in pH 0.6. A major ...
Leighfield Tod A - - 2014
Brevetoxins produced during algal blooms of the dinoflagellate Karenia are metabolized by shellfish into reduction, oxidation, and conjugation products. Brevetoxin metabolites comprised of amino acid- and lipid- conjugates account for a large proportion of the toxicity associated with the consumption of toxic shellfish. However, the disposition of these brevetoxin metabolites ...
Stalmach Angélique A Plant Products and Human Nutrition Group, Joseph Black Building, School of Medicine, College of Biomedical, Veterinary and Life Sciences, University of Glasgow, UK. - - 2014
Single servings of coffee beverage containing low (412 μmol), medium (635 μmol) and high (795 μmol) amounts of chlorogenic acids were administered to eleven healthy volunteers in a double-blind randomised controlled trial. Analysis of plasma and urine collected for 24 h revealed the presence of 12 metabolites in plasma and ...
Zhao Jinlian J Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, - - 2014
Arctium lappa and Tussilago farfara (Asteraceae) are two plant species used traditionally as antitubercular remedies. The aim of this study was i) to screen A. lappa and T. farfara extracts for activity against Mycobacterium tuberculosis and ii) to isolate and identify the compound(s) responsible for this reputed anti-TB effect. The ...
Sacristán Mara M Dpto. Tecnología de Alimentos, SGIT-INIA, Apdo. 8111, 28080, Madrid, - - 2014
Lathyrus species as legumes represent an alternative protein source for human and animal nutrition. Heavy consumption of these species can lead to lathyrism, caused by the non-protein amino acid β-N-oxalyl-L-α,β-diaminopropionic acid (β-ODAP). Currently, there is no well-defined level below which β-ODAP is considered non-toxic. In this work, the β-ODAP content ...
Wang Shao-Jie SJ Beijing National Laboratory for Molecular Sciences, Key Laboratory of Polymer Chemistry and Physics of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing, China. - - 2014
A supramolecular side-chain liquid crystalline (LC) polymer P4VP()x was prepared using poly(4-vinylpyridine) and a tolane based hemi-phasmid benzoic acid. P4VP()x exhibits good processability, forming smectic and hexagonal columnar LC phases at different compositions. Its photoluminescence properties depend on the LC structures.
Achar Raghu Ram RR Department of Biotechnology, JSS Technical Institutions Campus, Mysore, Sri Jayachamarajendra College of Engineering, Karnataka, 570 006, - - 2014
Vast applications of peroxidases create an increasing demand to characterize peroxidases from new sources with more applicability potential. The aim of the present study was to check the presence of peroxidase activity from Caralluma umbellata. This is the first report on the C. umbellata peroxidase (CUP). The presence of peroxidase ...
Poulin Jennifer Anne - - 2014
For the first time, molecular evidence of the structural role played by succinic acid within the macromolecular structure of Class Ia and Class Id resinites is presented. Using a novel gas chromatographic methodology, communol (Class Ia) and ozol (Class Id) moieties within the polylabdane matrix are shown to be cross-linked ...
Szostak Michal M School of Chemistry, The University of Manchester, Oxford Road, Manchester, M13 9PL, UK. michal.szostak@manchester.ac.uk - - 2014
The mechanism of a recently reported first mono-reduction of cyclic 1,3-diesters (Meldrum's acids) to β-hydroxy acids with SmI2-H2O has been studied using a combination of reactivity, deuteration, kinetic isotope and radical clock experiments. Most crucially, the data indicate that the reaction proceeds via reversible electron transfer and that water, as ...
Wang Qiqin Q Department of Pharmacy and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine & New Drug Research, Jinan University, Guangzhou 510632, China; Department of Analytical Chemistry, Faculty of Chemistry, University of Alcalá, Ctra. Madrid-Barcelona, Km. 33.600, Alcalá de Henares, 28871 Madrid, - - 2014
In order to obtain satisfactory column permeability, efficiency and selectivity for micro-HPLC, a capillary monolithic column containing O-9-[2-(methacryloyloxy)-ethylcarbamoyl]-10,11-dihydroquinidine (MQD) as chiral selector was re-optimized. The monolithic column was used to successfully enantioresolve a wide range of N-derivatized amino acids including alanine, leucine, methionine, threonine, phenylalanine, valine, serine, isoleucine, tryptophan, and ...
Ali Hatem Salama Mohamed HS Department of Food Science and Nutrition, College of Food Science and Agriculture, King Saud University, P.O. Box 2460, Riyadh, 11451, Kingdom of Saudi - - 2014
Whereas an abundance of literature is available on the occurrence of common proteinogenic amino acids (AAs) in edible fruits of the date palm (Phoenix dactylifera L.), recent reports on non-proteinogenic (non-coded) AAs and amino components are scarce. With emphasis on these components we have analyzed total hydrolysates of twelve cultivars ...
Fondekar Kamlesh Pai KP a Department of Chemistry , Goa University , Talegao Plateau, Goa 403206 , - - 2014
Reduction of santonic acid using Zn-HCl-ether yielded succinic anhydride derivatives via pinacolisation followed by rearrangement, whereas oxidation of santonic acid using ceric ammonium nitrate afforded five oxidative decarboxylation products.
Mutule Ilze I Department of Organic Chemistry, Latvian Institute of Organic Synthesis , Riga , - - 2014
Abstract The new histone deacylases inhibitors (HDACi) were synthesized in the class of 5-membered cyclic hydroxamic acids (5-CHA), showing medium size CHA as a new Zn-binding group. New reaction sequence was proposed for the synthesis of 5-membered alkylidene-cyclic-hydroxamic acids starting from butyrolactone. Compound 10c showed low µM activity on HeLa ...
Zhou Qiaoyu Q National Center for Nanoscience and Technology, 11 Beiyitiao Street, Zhongguancun, Beijing 100190, China. Fangy@nanoctr.cn - - 2014
We studied the self-assembly of trimesic acid on single- and few-layer graphene supported by SiO2 substrates. A scanning tunneling microscope operated under ambient conditions was utilized to image supramolecular networks of trimesic acid at liquid-graphene interfaces. Trimesic acid can self-assemble into large-scale, highly ordered adlayers on graphene surfaces. Phase transition ...
Danielsen E Michael EM Department of Cellular and Molecular Medicine, the Panum Institute, Faculty of Health Sciences, University of Copenhagen, Denmark. Electronic address: - - 2014
Okadaic acid (OA) is a polyether fatty acid produced by marine dinoflagellates and the causative agent of diarrhetic shellfish poisoning. The effect of OA on apical endocytosis in the small intestine was studied in organ cultured porcine mucosal explants. Within 0.5 - 1 h of culture, the toxin caused hyper ...
Min Fang-Fang FF State Key Laboratory of Food Science and Technology, Nanchang University, 235 Nanjing East Road, Nanchang 330047, Jiangxi, - - 2014
In vitro fermentation of polysaccharide from Cyclocarya paliurus leaves by human fecal inoculums was investigated by determining the changes in contents of neutral and reducing sugar and pH value, consumption of monosaccharide and production of short-chain fatty acids (SCFAs). During fermentation, the content of neutral sugar and reducing sugar decreased ...
Simsek Senay S Department of Plant Sciences, North Dakota State University , Fargo, ND , USA - - 2014
Abstract Oxygenated fatty acids are classified as secondary metabolites in wheat, produced by oxidation of free fatty acids (FFAs). Oxygenated fatty acids have significant impact on the organoleptic and sensory properties of food products and participate in regulation of defense and developmental processes in plants. The objective of this study ...
Rahn Anja K K AK McGill University, Department of Food Science and Agricultural Chemistry, 21,111 Lakeshore, Ste. Anne de Bellevue, Quebec H9X 3V9, - - 2015
Sodium chloride has been shown to promote chlorination of glycerol during thermal processing. However, the detailed mechanism of this reaction is not well understood. Preliminary experiments have indicated that the reaction mixture should contain an amino acid and it should be dissolved thoroughly in water in order to induce chlorination. ...
Pereira Eliana E CIMO-Escola Superior Agrária, Instituto Politécnico de Bragança, Campus de Santa Apolónia, 1172, 5301-855 Bragança, Portugal. - - 2014
The bioactivity (antioxidant and cytotoxic activities) of the aqueous and methanolic extracts of Arenaria montana L., a plant commonly used in Portuguese folk medicine, was evaluated and compared. Furthermore, the phytochemical composition was determined based on hydrophilic (sugars, organic acids and phenolic compounds) and lipophilic (fatty acids and tocopherols) compounds, ...
Tousch Didier - - 2014
In the present study, we obtained a dried burdock root extract (DBRE) rich in caffeoylquinic acids derivatives. We performed the chemical characterization of DBRE and explored its antihyperglycemic potential in both in vitro and in vivo experiments. Chemical analysis of DBRE using LC-MS and GC-MS revealed the presence of a ...
Heinze Cailin R CR Department of Clinical Sciences, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA - - 2014
Objective-To compare the nutrient composition of commercially available dog milk replacers with that of dog milk. Design-Prospective, cross-sectional study. Sample-5 dog milk samples and 15 samples of commercial dog milk replacers. Procedures-Dog milk and milk replacers were analyzed for concentrations of total protein, essential amino acids, sugars, total fat, essential ...
Wan Chunli C Department of Environmental Science and Engineering, Fudan University, 200433, Shanghai, - - 2014
Filamentous overgrowth in aerobic granular sludge processes can cause reactor failure. In this work, aerobic granules were cultivated in five identical sequencing batch reactors with acetate or glucose as the carbon source with various values of influent pH (4.5-8). Microscopic observations revealed that acidic pH, rather than the species of ...
Kabra Akhil N AN Department of Environmental Engineering, Yonsei University, Wonju, 220-710, South - - 2014
This study evaluated the toxicity of herbicide atrazine, along with its bioaccumulation and biodegradation in the green microalga Chlamydomonas mexicana. At low concentration (10 μg L(-1)), atrazine had no profound effect on the microalga, while higher concentrations (25, 50, and 100 μg L(-1)) imposed toxicity, leading to inhibition of cell growth and chlorophyll a ...
Tang Yao Y Key Laboratory of Food Nutrition and Safety, Ministry of Education of China, Tianjin University of Science and Technology, Tianjin 300457, China; Guelph Food Research Centre, Agriculture and Agri-Food Canada, 93 Stone Road West, Guelph, Ontario N1G 5C9, - - 2015
Quinoa (Chenopodium quinoa Willd.) is known for its exceptional nutritional value and potential health benefits. The present study identified the composition of different forms of extractable phenolics and betacyanins of quinoa cultivars in white, red and black, and how they contribute to antioxidant activities. Results showed that at least 23 ...
Tang Jian J Key Laboratory of Soft Chemistry and Functional Materials, Ministry of Education, Nanjing University of Science and Technology, Nanjing 210094, PR - - 2014
A new single-isomer cationic cyclodextrin, mono-6(A)-[3-(3-methoxypropyl)imidazol-1-ium]-6(A)-β-cyclodextrin chloride, has been synthesized and successfully used for the chiral separation of dansyl amino acids in capillary electrophoresis. With methoxy functionality, the new cationic cyclodextrin exhibits significantly improved enantioselectivities. Excellent enantioseparations for amino acids are obtained in chiral selector concentration range between 2.5mM to ...
Sun Shao-Ni SN Beijing Key Laboratory of Lignocellulosic Chemistry, Beijing Forestry University , Beijing 100083, - - 2014
An environmentally friendly steam explosion process of bamboo, followed by alkali and alkaline ethanol delignification, was developed to fractionate lignins. Results showed that after steam explosion the lignins isolated showed relatively low carbohydrate contents (0.55-1.76%) and molecular weights (780-1050 g/mol). For each steam-exploded sample, alkali-extracted lignins presented higher phenolic OH ...
Sinninghe Damsté Jaap S JS NIOZ Royal Netherlands Institute for Sea Research, Department of Marine Organic Biogeochemistry, PO Box 59, 1790 AB Den Burg, the Netherlands. - - 2014
Recently, iso-diabolic acid (13,16-dimethyl octacosanedioic acid) has been identified as a major membrane-spanning lipid of subdivisions 1 and 3 of the Acidobacteria, a highly diverse phylum within the Bacteria. This finding pointed to the Acidobacteria as a potential source for the bacterial glycerol dialkyl glycerol tetraethers that occur ubiquitously in ...
Riikonen Sampsa - - 2014
The ice quasi-liquid layer (QLL) forms on ice surfaces below the bulk ice melting temperature. It is abundant in the atmosphere and its importance for atmospheric chemistry is recognized. In the present work, we have studied the microscopic mechanisms of acid ionization on the QLL using ab initio molecular dynamics. ...
Michalski Radoslaw R Lodz University of Technology, - - 2014
Hydroperoxides of amino acid and amino acid residues (tyrosine, cysteine, tryptophan, and histidine) in proteins are formed during oxidative modification induced by reactive oxygen species. Amino acid hydroperoxides are unstable intermediates that can further propagate oxidative damage in proteins. The existing assays (oxidation of ferrous cation and iodometric assays) cannot ...
Kannaujiya Vinod K VK Laboratory of Photobiology and Molecular Microbiology, Centre of Advanced Study in Botany, Banaras Hindu University, Varanasi 221005, - - 2014
The genomic as well as structural relationship of phycobiliproteins (PBPs) in different cyanobacterial species are determined by nucleotides as well as amino acid composition. The genomic GC constituents influence the amino acid variability and codon usage of particular subunit of PBPs. We have analyzed 11 cyanobacterial species to explore the ...
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