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Kapoor Sonia S University Institute of Engineering and Technology, M. D. University, Rohtak, 124001, - - 2015
Sesame (Sesamum indicum L.) is an important oilseed crop grown in India, China, Korea, Russia, Turkey, Mexico, South America, and several countries of Africa. Sesame seeds are rich in oil, proteins, unsaturated fatty acids, vitamins, minerals, and folic acid. Nearly 70 % of the world's sesame is processed into oil ...
Futter Martyn N MN Department of Aquatic Sciences and Assessment, Swedish University of Agricultural Sciences (SLU), P.O. Box 7050, 750 07, Uppsala, Sweden, - - 2014
Long-term (1987-2012) water quality monitoring in 36 acid-sensitive Swedish lakes shows slow recovery from historic acidification. Overall, strong acid anion concentrations declined, primarily as a result of declines in sulfate. Chloride is now the dominant anion in many acid-sensitive lakes. Base cation concentrations have declined less rapidly than strong acid ...
Li You-Gui YG School of Chemistry and Chemical Engineering, Hefei University of Technology, 193 Tunxi Road, Hefei 230009, China. liyg@hfut.edu.cn ekantchev@hfut.edu.cn - - 2014
Transmetalation is a key elementary reaction of many important catalytic reactions. Among these, 1,4-addition of arylboronic acids to organic acceptors such as α,β-unsaturated ketones has emerged as one of the most important methods for asymmetric C-C bond formation. A key intermediate for the B-to-Rh transfer arising from quaternization on a ...
Wang Yuru - - 2014
Sulfate radical-based advanced oxidation process (SR-AOP) has received increasing application interests for the removal of water/wastewater contaminants. However, limited knowledge is available on its side effects. This study investigated the side effects in terms of the production of total organic bromine (TOBr) and brominated disinfection byproducts (Br-DBPs) in the presence ...
Li Lizhen L CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, 510301, People's Republic of - - 2014
α-Amylases from Bacillus licheniformis (BLA) and Bacillus amyloliquefaciens (BAA) are both important industrial enzymes with high similarity in structure but significant differences in thermostability. The mechanisms underlying this discrepancy are still poorly understood. Here, we investigated the role of two amino acids' insertion on the thermostability of these two group ...
Muselli Mickaël M Mickaël Muselli, Christine Baudequin, Christophe Hoarau, Laurent Bischoff Normandie Univ, COBRA, UMR 6014 et FR 3038, Univ Rouen, INSA Rouen, CNRS, IRCOF, 1 rue Tesnière, 76821 Mont Saint Aignan Cedex, France. christophe.hoarau@insa-rouen.fr - - 2014
Direct C-H arylation and alkenylation of 4,4'-dialkylimidazolones with a broad range of halides under palladium and copper catalysis have been developed. This methodology is applied to the preparation of recently discovered fatty acid synthetase (FAS) inhibitors.
Martín-Sómer Ana A Departamento de Química, Facultad de Ciencias, Módulo 13, Universidad Autónoma de Madrid, Campus de Excelencia UAM-CSIC, Cantoblanco, 28049 Madrid, Spain. - - 2014
The intrinsic acidity of CH2[double bond, length as m-dash]CHXH2, HC[triple bond, length as m-dash]CXH2 (X = N, P, As, Sb) derivatives and of their complexes with BeH2 and BH3 has been investigated by means of high-level density functional theory and molecular orbital ab initio calculations, using as a reference the ...
Stevenson Steven S Chemistry Department, Indiana-Purdue University at Fort Wayne , 2101 E. Coliseum Boulevard, Fort Wayne, Indiana 46805, United - - 2014
We demonstrate the manipulation of the Lewis acid strength to selectively fractionate different types of Gd3N metallofullerenes that are present in complex mixtures. Carbon disulfide is used for all Lewis acid studies. CaCl2 exhibits the lowest reactivity but the highest selectivity by precipitating only those gadolinium metallofullerenes with the lowest ...
Zhao Chenglong - - 2014
This work highlights Ni-catalyzed reductive coupling of alkyl acids with alkyl halides, particularly sterically hindered unactivated tertiary alkyl bromides for the production of all carbon quaternary ketones. The reductive strategy is applicable to α-selective synthesis of saturated, fully oxy-genated C-acyl glycosides through easy manipulations of the readily available sugar bromides ...
Choi Youngbo Y World Class University Program of Chemical Convergence for Energy & Environment, Institute of Chemical Processes, School of Chemical and Biological Engineering, Seoul National University, Seoul 151-742 - - 2014
Hierarchical porous catalysts have recently attracted increasing interest because of the enhanced accessibility to active sites on such materials. In this context, previously reported hierarchically mesoporous ASN and ASPN materials are evaluated by applying them to the dehydration of glycerol, and demonstrate excellent catalytic performance. In addition, a comprehensive understanding ...
Elias Peter M PM VA Medical Center, Dermatology (190), 4150 Clement St, San Francisco, California, United States, - - 2014
Sources of the Acid Mantle: Although the acid mantle initially was assumed to result from exogenous sources, such as sebum-derived free fatty acids, several endogenous acidifying mechanisms instead account for up to 2 pH units (a 200-fold increase in protons) of the overall pH of the stratum corneum (SC) (Table ...
Couttas Timothy A TA Prince of Wales Clinical School, University of New South Wales, Level 2, C25 Lowy Building, Sydney, NSW, 2052, - - 2014
Ceramides are a family of signalling lipids with diverse physiological functions that include pro-differentiative and pro-apoptotic signalling. Ceramides and their derivatives are major constituents of myelin, maintaining neuronal conductivity. Ceramides are synthesized by ceramide synthases, of which there are six isoforms in mammals (CERS1-6). These enzymes catalyse the transfer of ...
Gonzalez Raul S RS Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, - - 2014
Recent attention has been paid to the microscopic detection of medications potentially harmful to the gastrointestinal tract, such as sevelamer(1) and bile acid sequestrants.(2) We have recently encountered a case of the bile acid sequestrant colestipol in the colon, albeit with unusual macroscopic and microscopic findings not previously described.A 55-year-old ...
Liu Kuan-Lin - - 2014
Dealuminated zeolites are widely used acid catalysts in research and chemical industry. Bulk-level studies have revealed that the improved catalytic performance results from an enhanced molecular transport as well as from changes in the active sites. However, fully exploiting this information in rational catalysts design still requires insight in the ...
Victora Andrea A Department of Chemistry and Zukunftskolleg, Universität Konstanz, 78457 Konstanz, - - 2014
NMR chemical shift predictions based on empirical methods are nowadays indispensable tools during resonance assignment and 3D structure calculation of proteins. However, owing to the very limited statistical data basis, such methods are still in their infancy in the field of nucleic acids, especially when non-canonical structures and nucleic acid ...
Usmanova Dinara R DR *Moscow Institute of Physics and Technology, Institutskiy pereulok 9, g.Dolgoprudny, 141700, Russia Bioinformatics and Genomics Programme, Centre for Genomic Regulation (CRG) 88 Dr. Aiguader, 08003 Barcelona, Spain **Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain. - - 2014
The nature of factors governing the tempo and mode of protein evolution is a fundamental issue in evolutionary biology. Specifically, whether or not interactions between different sites, or epistasis, are important in directing the course of evolution became one of the central questions. Several recent reports have scrutinized patterns of ...
Wang Huipin H Faculty of Forensic Science, Southern Medical University, Guangzhou, China; Zhongshan Forensic Science Institute, Zhongshan, - - 2014
Presence of diatoms in tissues has been considered as a significant sign of drowning. However, there are limitations in the present extraction methods. We developed a new digestion method using the Lefort aqua regia solution (3:1 nitric acid to hydrochloric acid) for diatom extraction and evaluated the digestive capability, diatom ...
Blasco Salvador S Instituto de Ciencia Molecular, C/Catedrático José Beltrán 2, 46980 Paterna, Valencia, Spain. - - 2014
Interactions of different hydrophilic (His, Asp, Glu,) and hydrophobic (Ala, Phe, Tyr, Trp) amino acids in water with a scorpiand aza-macrocycle (L1) containing a pyridine group in the ring and its derivative (L2) bearing a naphthalene group in the tail have been analysed by potentiometric and calorimetric measurements. Theoretical calculations ...
Chua Yong Guan - - 2014
This study describes the approach of amino acid and monosaccharide combined with Hotelling T2 range plot to identify edible bird nests (EBN) and non-EBN. Prior to the approach, an analytical method was developed and validated to quantify monosaccharides in EBN. Hotelling T2 range plot of both compounds were successful in ...
DePalma Joseph W - - 2014
Unraveling the chemical mechanism of atmospheric new particle formation (NPF) has important implications for the broader understanding of the role of aerosols in global climate. We present computational results of the transition states and activation barriers for growth of atmospherically relevant positively charged molecular clusters containing ammonia and sulfuric acid. ...
Azzolini Michela M Dipartimento di Biotecnologie, Università degli Studi di Verona, Verona, - - 2014
Although the positive role of non-Saccharomyces yeasts on the overall quality of wine is encouraging research into their oenological potential, current knowledge on the topic is still far from satisfactory. This work analyzes the contribution of starter cultures of Torulaspora delbrueckii, inoculated sequentially with Saccharomyces cerevisiae (multi-starter fermentation), on the ...
Radice Matteo M Universidad Estatal - - 2014
Nowadays, data concerning the composition of Caryodendron orinocense Karst. (Euphorbiaceae) and Bactris gasipaes Kunth (Arecaceae) seed oils are lacking. In light of this fact, in this paper fatty acids and unsaponifiable fraction composition have been determined using GC-MS, HPLC-DAD (Diode Array Detector), NMR approaches and possible future applications have been ...
Risso Valeria A VA Departamento de Quimica Fisica, Facultad de Ciencias, Universidad de Granada, 18071-Granada, - - 2014
Local protein interactions ("molecular context" effects) dictate amino acid replacements and can be described in terms of site-specific, energetic preferences for any different amino acid. It has been recently debated whether these preferences remain approximately constant during evolution or whether, due to co-evolution of sites, they change strongly. Such research ...
Mandal Asim A Renal Divisions, Brigham and Women's Hospital and VA Boston Healthcare System, Harvard Institutes of Medicine, Boston, MA - - 2014
Uric acid, generated from the metabolism of purines, has proven and emerging roles in human disease. Serum uric acid is determined by production and the net balance of reabsorption or secretion by the kidney and intestine. A detailed understanding of epithelial absorption and secretion of uric acid has recently emerged, ...
Wang Bingxiang B Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin, 300072, P.R. - - 2014
Diamino-moiety-functionalized silica nanoparticles with the size of 118±12 nm were successfully synthesized and directly introduced into chiral capillary electrophoresis system to improve the enantioseparation of 9-fluorenyl methoxycarbonyl derivatized amino acids using norvancomycin as chiral selector. Under acidic background electrolyte conditions, functional silica nanoparticles can be readily adsorbed onto the inner ...
Walker Rebecca R Department of Food Science, University of Massachusetts, Amherst, MA 01003, USA. - - 2014
Consumption of biologically active amounts of omega-3 fatty acids is linked to improved human health, which has partly been attributed to their important role in brain development and cardiovascular health. Western diets are relatively low in omega-3 fatty acids and many consumers turn to supplements or functional foods to increase ...
Gioiello Antimo A Department of Pharmaceutical Sciences, University of Perugia, Via del Liceo 1, I-06122 Perugia (Italy). - - 2014
Bile acids are a peculiar class of steroidal compounds that never cease to amaze. From being simple detergents with a primary role in facilitating the absorption of fats and fat-soluble vitamins, bile acids are now widely considered as crucial hormones endowed with genomic and non-genomic functions that are mediated by ...
Yan Pu-Cha PC Zhejiang Jiuzhou Pharmaceutical Co., Ltd., 99 Waisha Road, Jiaojiang District, Taizhou City, Zhejiang Province 318000, P. R. China. - - 2014
A new efficient and highly enantioselective direct asymmetric hydrogenation of α-keto acids employing the Ir/SpiroPAP catalyst under mild reaction conditions has been developed. This method might be feasible for the preparation of a series of chiral α-hydroxy acids on a large scale.
Shaik Firdose Begum FB Department of Zoology, Yogi Vemana University, Kadapa, 516 003, AP, - - 2014
The aim of this paper is to review the developments of farnesoid X receptor (FXR) biology, its ligands, and various functions, in particular we discuss the anti-inflammatory and anti-fibrotic role in chronic inflammatory diseases. FXR is a ligand-dependent transcription factor belonging to the nuclear hormone receptor superfamily. The accrued data ...
Liu Xiandong X State Key Laboratory for Mineral Deposits Research, School of Earth Sciences and Engineering, Nanjing University, Nanjing 210093, P. R. China. - - 2014
We report a first principles molecular dynamics (FPMD) study of surface acid chemistry of the two growth surfaces of quartz, (101[combining macron]0) (including Alpha and Beta terminations) and (101[combining macron]1) facets. The interfacial hydration structures are characterized in detail and the intrinsic pKas of surface silanols are evaluated using the ...
Liu Yan Y School of Chemistry and Chemical Engineering and State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong University, Shanghai 200240 (China). - - 2014
Two chiral carboxylic acid functionalized micro- and mesoporous metal-organic frameworks (MOFs) are constructed by the stepwise assembly of triple-stranded heptametallic helicates with six carboxylic acid groups. The mesoporous MOF with permanent porosity functions as a host for encapsulation of an enantiopure organic amine catalyst by combining carboxylic acids and chiral ...
Wu Jing J Food and Biobased Research, Wageningen University and Research Center, Bornse Weilanden 9, 6708 WG, Wageningen (The Netherlands); Department of Chemical Engineering and Chemistry, Eindhoven University of Technology, Den Dolech 2, 5600 MB, Eindhoven (The Netherlands); Dutch Polymer Institute (DPI), P.O. Box 902, 5600 AX, Eindhoven (The - - 2014
New carbohydrate-based polyesters were prepared from isoidide-2,5-dimethanol (extended isoidide, XII) through melt polymerization with dimethyl esters of terephthalic acid (TA) and furan-2,5-dicarboxylic acid (FDCA), yielding semi-crystalline prepolymers. Subsequent solid-state post-condensation (SSPC) gave high molecular weight (Mn =30 kg mol(-1) for FDCA) materials, the first examples of high Mn , semi-aromatic homopolyesters containing ...
Vasudevan Sukumaran - - 2014
The theoretical estimation of the dissociation constant, or pKa, of weak acids continues to be a challenging field. Here we show that ab initio Car-Parrinello molecular dynamics simulations in conjunction with metadynamics calculations of the free energy profile of the dissociation reaction provide reasonable estimates of the pKa value. Water ...
Zhou Yige - - 2014
The electrochemical detection of nucleic acids using an electrocatalytic reporter system and nanostructured microelectrodes is a powerful approach to ultrasensitive biosensing. In this report we systematically studied for the first time the behavior of an electrocatalytic redox pair at electrodes with varying structures and sizes. We found that the electrode ...
Mondal Buddhadeb B Department of Chemistry, Indian Institute of Technology Guwahati, Guwahati 781039, India. - - 2014
Primary amino acids are found to be good enantioselective catalysts for the direct asymmetric Mannich reaction between 2-amino acetophenone and aldehydes. The 2-aryl-2,3-dihydro-4-quinoline products are obtained in moderate to good yields and good to high enantioselectivities with 10 mol% of the primary amino acid catalyst under mild reaction conditions.
Knaus Tanja T Manchester Institute of Biotechnology, Faculty of Life Sciences, University of Manchester, 131 Princess Street, Manchester, M1 7DN, UK. - - 2014
Ene-reductases (ERs) are flavin dependent enzymes that catalyze the asymmetric reduction of activated carbon-carbon double bonds. In particular, α,β-unsaturated carbonyl compounds (e.g. enals and enones) as well as nitroalkenes are rapidly reduced. Conversely, α,β-unsaturated esters are poorly accepted substrates whereas free carboxylic acids are not converted at all. The only ...
Wang Qian Q Institute of Molecular Functional Materials, and Department of Biology and Chemistry, City University of Hong Kong, Tat Chee Avenue, Kowloon Tong, Hong Kong, P. R. China. - - 2014
The oxidation of ascorbic acid (H2A) by [Ru(VI)(N)(L)(MeOH)](+) in aqueous acidic solutions has the following stoichiometry: 2[Ru(VI)(N)] + 3H2A → 2[Ru(III)(NH2-HA)](+) + A. Mechanisms involving HAT/N-rebound at low pH (≤2) and nucleophilic attack at the nitride at high pH (≥5) are proposed.
Heberlig Graham W GW Department of Chemistry, Centre for Catalysis Research and Innovation, University of Ottawa , Ottawa, ON K1N 6N5, - - 2014
Zearalenone and radicicol are highly related resorcylic acid lactones with the rare property of having opposite stereochemical configurations of the secondary alcohol involved in lactone formation. The ability of the thioesterases from the zearalenone and radicicol biosynthetic pathways to macrocyclize both d and l configured synthetic substrate analogs was biochemically ...
Yang Kin S - - 2014
A general, asymmetric synthesis of amino acid derivatives is reported. Masked acyl cyanide (MAC) reagents are shown to be effective umpolung synthons for enantioselective additions to N-Boc-aldimines. The reactions are catalyzed by a modified cinchona alkaloid, which can function as a bifunctional, hydrogen bonding catalyst, and afford adducts in excellent ...
Pararasa Chathyan C School of Life and Health Science and Aston Research Centre for Healthy Ageing, Aston University, Aston Triangle, Birmingham, B4 7ET, UK, - - 2014
A common feature of ageing is the alteration in tissue distribution and composition, with a shift in fat away from lower body and subcutaneous depots to visceral and ectopic sites. Redistribution of adipose tissue towards an ectopic site can have dramatic effects on metabolic function. In skeletal muscle, increased ectopic ...
Nithyanand Paramasivam P School of Chemical & Biotechnology, Centre for Research on Infectious Diseases (CRID), SASTRA University, Tirumalaisamudram, Thanjavur, 613401, Tamil Nadu, India, - - 2014
Group A Streptococci (GAS) are involved in a number of life threatening diseases and biofilm formation by these pathogens are considered as an important virulence determinant as it mediates antibiotic resistance among them. In the present study, we have explored the ability of (+)-usnic acid, a lichen secondary metabolite, as ...
Bekdeşer Burcu - - 2014
Hypochlorous acid (HOCl) is an important reactive oxygen species (ROS), non-radical, and taking part in physiological processes concerned with the defense of the organism, but there has been limited information regarding its scavenging by polyphenols. This study was designed to examine the HOCl scavenging activity of several polyphenols and microwave ...
Schellart Nico A M NA Biomedical Engineering and Physics, Academic Medical Center, University of Amsterdam, Amsterdam, The - - 2014
Schellart NAM. Free fatty acids do not influence venous gas embolism in divers. Aviat Space Environ Med 2014; 85:1086-91. Decompression sickness is caused by bubbles of inert gas predominantly found in the venous circulation. Bubbles may exist longer when covered by a surfactant layer reducing surface tension. Surfactant candidates, based ...
Crisma Marco M Institute of Biomolecular Chemistry, Padova Unit, CNR, 35131, Padova, - - 2014
The preferred helical screw senses of chiral α-amino acids with a C(α) -tetrasubstituted α-carbon atom, as determined in the crystal state by X-ray diffraction analyses on derivatives and peptides, are reviewed. This survey covers C(α) -methylated and C(α) -ethylated α-amino acids, as well as α-amino acids cyclized on the α-carbon, ...
Cornum Rhonda L RL United States Army Comprehensive Soldier Fitness, Zachary Taylor Building (NC3), 2530 Crystal Drive, Suite 5122, Arlington,VA - - 2014
The first day of this conference reviewed the literature on the intake of omega-3 fatty acids, in all forms, around the world. Clinical trials using omega-3 fatty acids for a variety of pathological conditions, and studies examining omega-3 supplementation in nonclinical populations, were examined. Finally, the basic science describing possible ...
Davis Betty A BA Performance Optimization Research Team, Department of Defense Combat Feeding Directorate, U.S. Army Natick Soldier Research, Development and Engineering Center, 15 Kansas Street, Natick, MA - - 2014
Increasingly, private and military consumers are becoming aware of the positive benefits of a diet rich in omega-3 fatty acids (FAs) as health claims range from reducing inflammation to improving mood. The number of positive scientific articles supporting these claims is rapidly increasing, leading the military to examine the possibility ...
Hibbeln Joseph R JR Section of Nutritional Neurosciences, Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 5625 Fishers Lane, Room 3N-07, MSC 9410, Bethesda, MD - - 2014
The current burden of psychological distress and illness poses as a significant barrier to optimal force efficacy. Here we assess nutrients in military diets, specifically highly unsaturated essential fatty acids, in the reduction of risk or treatment of psychiatric distress. Moderate to strong evidence from several meta-analyses of prospective cohort ...
Bailes Julian E JE NorthShore Neurological Institute, NorthShore University Health System, University of Chicago Pritzker School of Medicine, 2650 Ridge Avenue, Kellogg 3rd Floor, Evanston, IL - - 2014
Scientific knowledge of omega-3 fatty acids (FAs) has grown in the last decade to a greater understanding of their mechanisms of action and their potential therapeutic effects. Omega-3 FAs have shown therapeutic potential with respect to hyperlipidemia, depression, attention-deficit hyperactivity disorder, and mild cognitive impairment. Laboratory evidence and clinical interest ...
Muldoon Matthew F MF Heart and Vascular Institute, University of Pittsburgh School of Medicine, Old Engineering Hall, Room 506, University of Pittsburgh, Pittsburgh, PA - - 2014
Low consumption of the omega-3 fatty acids, eicosapentaenoic and docosahexaenonic acids, is linked to delayed brain development and, in late life, increased risk for Alzheimer's disease. The current review focuses on cognitive functioning during midlife and summarizes available scientific evidence relevant to the hypothesis that adequate dietary consumption of the ...
Innis Sheila M SM Nutrition Research Program, Child and Family Research Institute, Department of Paediatrics, University of British Columbia, 950 West 28th Avenue, Vancouver, British Columbia V5Z 4H4, - - 2014
The possibility that western diets poor in omega-3 and rich in omega-6 fatty acids contribute to the increasing burden of chronic diseases including neurological problems is becoming recognized. Modern, westernized diets provide 80 to 90% of polyunsaturated fatty acids as omega-6 linoleic acid (LA) and are depleted in omega-3 fatty ...
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