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Schellart Nico A M NA Biomedical Engineering and Physics, Academic Medical Center, University of Amsterdam, Amsterdam, The - - 2014
Schellart NAM. Free fatty acids do not influence venous gas embolism in divers. Aviat Space Environ Med 2014; 85:1086-91. Decompression sickness is caused by bubbles of inert gas predominantly found in the venous circulation. Bubbles may exist longer when covered by a surfactant layer reducing surface tension. Surfactant candidates, based ...
Li Zhaodong - - 2014
We report herein an efficient and general method for the deboronofluorination of alkylboronates. Thus with the catalysis of AgNO3, the reactions of various alkylboronic acids or their pinacol esters with Selectfluor reagent in acidic aqueous solution afforded the corresponding alkyl fluorides under mild conditions. A broad substrate scope and wide ...
Horn Anselm H C AH Bioinformatik, Institut für Biochemie, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Fahrstr. 17, 91054, Erlangen, Germany, - - 2014
Isolated amino acids play an important role in biochemistry and are therefore an interesting object of study. Atomistic molecular dynamics (MD) simulations can provide a high-resolution picture of the dynamic features of these species, especially in their biological environment. Unfortunately, most standard force field packages lack libraries for isolated amino ...
Kallemeijn Wouter W WW University of Amsterdam, - - 2014
Retaining β-exoglucosidases operate by a mechanism in which the key amino acids driving the glycosidic bond hydrolysis act as catalytic acid/base and nucleophile. Recently we designed two distinct classes of fluorescent cyclophellitol-type activity-based probes (ABPs) that exploit this mechanism to covalently modify the nucleophile of retaining β-glucosidases. Whereas β-epoxide ABPs ...
Dang Cuong Cao - - 2014
Amino acid replacement rate matrices are a crucial component of many protein analysis systems such as sequence similarity search, sequence alignment, and phylogenetic inference. Ideally, the rate matrix reflects the mutational behavior of the actual data under study; however, estimating amino acid replacement rate matrices requires large protein alignments and ...
Mostarda Serena S Laboratory of Medicinal and Advanced Synthetic Chemistry (Lab MASC), Department of Pharmaceutical Sciences, University of Perugia, Via del Liceo 1, I-06123 Perugia, Italy. - - 2014
An efficient method for the C3-glucuronidation of bile acids is developed under flow conditions. A modular mesoreactor assisted flow set-up was combined with statistical design of experiments to speed up the optimization of the Koenigs-Knorr reaction in terms of yield, regioselectivity, costs, as well as technical and practical standpoints. Using ...
Chen Ning - - 2014
Detection of brain gliomas at the earliest stage is of great importance to improve the outcomes but remains the most challenging task. In this study, oleic acid capped manganese oxide (MnO) NPs were prepared by the thermal decomposition of manganese oleate precursors and then transformed to water-dispersible MnO NPs by ...
Deshlahra Prashant P Department of Chemical and Biomolecular Engineering, University of California , Berkeley, California 94720, United - - 2014
Reactivity descriptors describe catalyst properties that determine the stability of kinetically relevant transition states and adsorbed intermediates. Theoretical descriptors, such as deprotonation energies (DPE), rigorously account for Brønsted acid strength for catalytic solids with known structure. Here, mechanistic interpretations of methanol dehydration turnover rates are used to assess how charge ...
Zhou Chenguang - - 2014
Nanoparticles have shown great promise for improving the efficacy of nucleic acid drugs that lack permeability and bioavailability needed for reaching their intracellular site of action. The pharmacokinetics of the nucleic acid nanomedicines contributes greatly to their pharmacodynamic and toxicity characteristics. The pharmacokinetics of nanomedicines is determined by their physiochemical ...
Tatsuno Ichiro I Center for Diabetes, Metabolism and Endocrinology, Toho University Sakura Medical Center, 564-1 Shimoshizu, Sakura, Chiba 285-8741, - - 2014
A number of epidemiological/observational studies, as well as large-scale randomized intervention studies, have been conducted to provide evidence for the efficacy of ω-3 fatty acids against atherosclerotic diseases. Currently, ω-3 fatty acids are commercially available in many parts of the world containing the same active ingredients as Lotriga(®) (ω-3-acid ethyl ...
Bowman David T DT Department of Chemistry and Chemical Biology, McMaster University, 1280 Main St W., Hamilton, ON, Canada, L8S 4 - - 2014
Naphthenic acids (NAs) accumulate in oil sands process-affected water (OSPW) as a result of the water-based extraction processes, and represent one of the toxic fractions in OSPW. They exist as a complex mixture and so the development of an analytical method to characterize and quantify individual acids has been an ...
Toda Yasunori Y Department of Chemistry and Vanderbilt Institute of Chemical Biology, Vanderbilt University , Nashville, Tennessee 37235, United - - 2014
The first highly diastereo- and enantioselective additions of a halogen and phosphoramidic acid to unactivated alkenes have been developed, catalyzed by a chiral Brønsted acid. A unique feature of these additions is the opportunity for stereocontrol at two noncontiguous chiral centers, carbon and phosphorus, leading to cyclic P-chiral phosphoramidates. In ...
Zhu Lixin L Women and Children's Hospital of Buffalo, Digestive Diseases and Nutrition Center, Department of Pediatrics, The State University of New York at Buffalo, NY, - - 2014
Here we review recent findings and hypotheses on the roles of gut microbiome in the pathogenesis of non-alcoholic fatty liver diseases (NAFLD). Microbial metabolites and cell components contribute to the development of hepatic steatosis and inflammation, key components of non-alcoholic steatohepatitis (NASH), the severe form of NAFLD. Altered gut microbiome ...
Bera Milan M Department of Chemistry, Indian Institute of Technology Bombay , Powai, Mumbai 400076, - - 2014
A nitrile-based template attached with a phenylacetic acid framework promoted meta-selective C-H bond olefination. This palladium-catalyzed protocol is applicable to a wide range of substituted phenylacetic acids and tolerates a variety of functional groups. The versatility of this operationally simple method has been demonstrated through drug diversification.
Knight Michael J MJ School of Biochemistry, University of Bristol, - - 2014
Fatty acid ethyl esters are secondary metabolites that are produced during microbial fermentation, in fruiting plants, and in higher organisms during ethanol stress. In particular, volatile medium-chain fatty esters are important flavor compounds that impart desirable fruit aromas to fermented beverages including beer and wine. The biochemical synthesis of medium-chain ...
Kuhn Hartmut H Institute of Biochemistry, University Medicine Berlin - Charite, Chariteplatz 1, CCO-Building, Virchowweg 6, D-10117 Berlin, Germany. Electronic address: - - 2014
Lipoxygenases (LOXs) form a heterogeneous class of lipid peroxidizing enzymes, which have been implicated in cell proliferation and differentiation but also in the pathogenesis of various diseases with major public health relevance. As other fatty acid dioxygenases LOX oxidize polyunsaturated fatty acids to their corresponding hydroperoxy derivatives, which are further ...
Chankhamjon Pranatchareeya P Leibniz Institute for Natural Product Chemistry and Infection Biology, Departments Biomolecular Chemistry and Infection Biology, Beutenbergstr. 11a, 07745 Jena (Germany) - - 2014
Aspirochlorine (1) is an epidithiodiketopiperazine (ETP) toxin produced from koji mold (Aspergillus oryzae), which has been used in the oriental cuisine for over two millennia. Considering its potential risk for food safety, we have elucidated the molecular basis of aspirochlorine biosynthesis. By a combination of genetic and chemical analyses we ...
Kalaji Ali A Chemical Sciences and Engineering Division, Argonne National Laboratory , 9700 S Cass Avenue, Argonne, Illinois 60439, United - - 2014
Crystalline precipitates resulting from the hydrolysis and subsequent condensation of Hf(IV) aqueous acidic solutions at 60-95 °C are examined and compared. By varying the concentrations of the acid and sulfate source, a variety of complex hafnium-oxo-hydroxo-sulfate clusters are isolated and structures accessed. Four novel compounds were discovered, while the structures ...
Kuznetsov Petr P Department of Renewable Resources, 4-42 Earth Sciences Building, University of Alberta, Edmonton, AB T6G 2E3, Canada. Electronic address: - - 2014
Bitumen extraction from oil sands ores after surface mining produces different tailings waste streams: 'froth treatment tailings' are enriched in pyrite relative to other streams. Tailings treatment can include addition of organic polymers to produce thickened tailings (TT). TT may be further de-watered by deposition into geotechnical cells for evaporative ...
McClure Elizabeth M EM Department of Social, Statistical and Environmental Health Sciences, Research Triangle Institute, Durham, North - - 2014
Objective Postpartum hemorrhage (PPH) is a major cause of maternal mortality, with almost 300,000 cases and ∼72,000 PPH deaths annually in sub-Saharan Africa. Novel prevention methods practical in community settings are required. Tranexamic acid, a drug to reduce bleeding during surgical cases including postpartum bleeding, is potentially suitable for community settings. ...
Zhou Yu-Xiao YX Hefei National Laboratory for Physical Sciences at the Microscale, Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026 (P.R. China), Fax: - - 2014
For the first time, a ∼100 % sulfonic acid functionalized metal-organic framework (MOF), MIL-101-SO3 H, with giant pores has been prepared by a hydrothermal process followed by a facile postsynthetic HCl treatment strategy. The replete readily accessible Lewis acidic and especially Brønsted acidic sites distributed throughout the framework as well as ...
Schürch Stefan S Department of Chemistry and Biochemistry, University of Bern, CH-3012, Bern, - - 2014
Nucleic acids play key roles in the storage and processing of genetic information, as well as in the regulation of cellular processes. Consequently, they represent attractive targets for drugs against gene-related diseases. On the other hand, synthetic oligonucleotide analogues have found application as chemotherapeutic agents targeting cellular DNA and RNA. ...
Ramesh Nivarthi N Department of Chemistry, Indian Institute of Technology Madras, Chennai 600 036, India. - - 2014
Multi-component organic interfaces with molecular-level mixing were prepared by integrating benzoic acid appended thiophene amphiphile [4-(6-(thiophene-3-carbonyloxy)hexyloxy)benzoic acid] (T6BA) and (±)-α-lipoic acid onto the Au surface. On a flat surface with infinite radii of curvature, T6BA and (±)-α-lipoic acid, endowed with chemically distinct end-groups, provided sufficient length mismatch to gain conformational ...
Gawinkowski Sylwester S Institute of Physical Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, 01-224 Warsaw, Poland. - - 2014
The procedure for identifying components in a mixture was developed and tested on Raman spectra of mixtures of solid amino acids, using the spectra of single amino acids as templates. The method is based on finding the optimum scaling coefficients of the linear combination of template spectra that minimize the ...
Khot Vinita V Department of Nutritional Medicine, Interactive Research School for Health Affairs, Bharati Vidyapeeth Deemed University, Pune-411043, - - 2014
Studies have adequately demonstrated the importance of maternal nutrition, particularly, micronutrients (folic acid, vitamin B12) and long chain polyunsaturated fatty acids (LCPUFAs) in determining pregnancy outcome. Reports indicate that children born preterm or to mothers with preeclampsia are at increased risk of developing cardiovascular diseases (CVD) in later life although ...
Fleming Ingrid I Institute for Vascular Signalling, Centre for Molecular Medicine, Goethe University, Frankfurt am Main, Germany - - 2014
Over the last 20 years, it has become clear that cytochrome P450 (P450) enzymes generate a spectrum of bioactive lipid mediators from endogenous substrates. However, studies focused on the determining biologic activity of the P450 system have focused largely on the metabolites generated by one substrate (i.e., arachidonic acid). However, ...
Collard Marie M Laboratoire de Biologie Marine, Université Libre de Bruxelles, 50 avenue F.D. Roosevelt, Brussels, 1050, Belgium; Analytical, Environmental and Geo-Chemistry, Earth Systems Science Research Group, Vrije Universiteit Brussel, Pleinlaan 2, Brussels, 1050, - - 2014
Increasing atmospheric carbon dioxide concentration alters the chemistry of the oceans towards more acidic conditions. Polar oceans are particularly affected due to their low temperature, low carbonate content and mixing patterns, for instance upwellings. Calcifying organisms are expected to be highly impacted by the decrease in the oceans' pH and ...
Houwaart Stefanie S Institute of Pharmaceutical Sciences, University of Freiburg, Albertstrasse 25, 79104 Freiburg - - 2014
Echinocandins are cyclic nonribosomal hexapeptides based mostly on nonproteinogenic amino acids and displaying strong antifungal activity. Despite previous studies on their biosynthesis by fungi, the origin of three amino acids, trans-4- and trans-3-hydroxyproline, as well as trans-3-hydroxy-4-methylproline, is still unknown. Here we describe the identification, overexpression, and characterization of GloF, ...
Garcia-Ruiz Carmen C Department of Cell Death and Proliferation, Instituto Investigaciones Biomédicas de Barcelona, CSIC, Barcelona, and Liver Unit-Hospital Clinic-IDIBAPS; Centro de Investigación Biomédica en Red (CIBERehd), Barcelona, Spain; University of Southern California Research Center for Alcohol Liver and Pancreatic Diseases and Cirrhosis, Keck School of Medicine, USC, Los Angeles, CA, USA. Electronic address: - - 2014
Steatohepatitis (SH) is an intermediate stage of fatty liver disease and one of the most common causes of chronic liver disease worldwide that may progress to cirrhosis and liver cancer. SH encompasses alcoholic and nonalcoholic steatohepatitis, the latter being of particular concern due to its association with obesity and insulin ...
González-Domínguez Raúl R Department of Chemistry and CC.MM, Faculty of Experimental Sciences, University of Huelva, Campus de El Carmen, 21007 Huelva, Spain; Campus of Excellence International ceiA3, University of Huelva, Spain; Research Center of Health and Environment (CYSMA), University of Huelva, Campus de El Carmen, 21007 Huelva, Spain. Electronic address: - - 2014
Alzheimer's disease (AD) is the most common neurodegenerative disorder worldwide, but its etiology is still not completely understood. The identification of underlying pathological mechanisms is becoming increasingly important for the discovery of biomarkers and therapies, for which metabolomics presents a great potential. In this work, we studied metabolic alterations in ...
Zhang Feng F Jiangsu Province Key Laboratory of Stem Cell Research, Medical College, Soochow University, Suzhou 215123, People's Republic of - - 2014
Silks spun by silkworms and spiders feature outstanding mechanical properties despite being spun under benign conditions. The superior physical properties of silk are closely related to its complicated hierarchical structures constructed from nanoscale building blocks, such as nanocrystals and nanofibrils. Here, we report a novel silk dissolution behavior, which preserved ...
Noto Antonio A Neonatal Intensive Care Unit, Puericulture Institute and Neonatal Section, Department of Surgical Sciences, Azienda Ospedaliera Universitaria, University of Cagliari, Cagliari , Italy - - 2014
Abstract Objective: A supervised multivariate model to classify the metabolome alterations between autistic spectrum disorders (ASD) patients and controls, siblings of autistic patients, has been realized and used to realize a network model of the ASD patients' metabolome. In our experiment we propose a quantification of urinary metabolites with the ...
Poupin Nathalie N INRA, CRNH-IdF, UMR914 Nutrition Physiology and Ingestive Behavior, Paris, France; AgroParisTech, CRNH-IdF, UMR914 Nutrition Physiology and Ingestive Behavior, Paris, - - 2014
Body tissues are generally 15N-enriched over the diet, with a discrimination factor (Δ15N) that varies among tissues and individuals as a function of their nutritional and physiopathological condition. However, both 15N bioaccumulation and intra- and inter-individual Δ15N variations are still poorly understood, so that theoretical models are required to understand ...
Yang Pei P School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, P.R. China - - 2014
Amino-acid neurotransmitter system dysfunction plays a major role in the pathophysiology of depression. Several studies have demonstrated the potential of amino acids as a source of neuro-specific biomarkers could be used in future diagnosis of depression. Only partial amino acids such as glycine and asparagine were determined from certain parts ...
Ko Eun Jung - - 2014
Abstract Hyaluronic acid(HA) fillers are increasingly used for midface augmentation, which can be performed for facial rejuvenation. Previous study proved that RF treatment prior to HA filler injection may provide synergistic and long-lasting effects for the reduction of nasolabial fold(NLF) wrinkles. Here, we report a case in which the efficacy ...
Shewchuk Brian M BM Department of Biochemistry and Molecular Biology, Brody School of Medicine, East Carolina University, Greenville, NC 27834, United States. Electronic address: - - 2014
The hypothalamic-pituitary (H-P) axis integrates complex physiological and environmental signals and responds to these cues by modulating the synthesis and secretion of multiple pituitary hormones to regulate peripheral tissues. Prostaglandins are a component of this regulatory system, affecting multiple hormone synthesis and secretion pathways in the H-P axis. The implications ...
Kler Pablo A PA Institute of Physical and Theoretical Chemistry, Faculty of Science, Eberhard Karls Universität Tübingen, Auf der Morgenstelle 18, 72076,, Tübingen, Germany, - - 2014
Isotachophoresis (ITP) has long been used alone but also as a preconcentration technique for capillary electrophoresis (CE). Unfortunately, up to now, its application is restricted to relatively strong acids and bases as either the degree of (de)protonation is too low or the water dissociation is too high, evoking zone electrophoresis. ...
Phan Ngoc N NN Department of Chemical and Biological Engineering, Iowa State University, Ames, IA, 50011-2230, - - 2014
Ketoacyl reductases (KRs), hydroxyacyl dehydratases (HDs), and enoyl reductases (ERs) are part of the fatty acid/polyketide synthesis cycle. They are known as acyl dehydrogenases, enoyl hydratases, and hydroxyacyl dehydrogenases, respectively, when catalyzing their reverse reactions. Earlier, we classified these enzymes into four KR, eight HD, and five ER families by ...
Murai Kenichi K Graduate School of Pharmaceutical Sciences, Osaka University, 1-6, Yamada-oka, Suita, Osaka, 565-0871 (Japan), Fax: (+81) 6-6879-8229. - - 2014
The results of studies leading to the development of enantioselective desymmetrizing, bromolactonization reactions of symmetric olefinic dicarboxylic acids, which are promoted by a C3 -symmetric trisimidazoline catalyst, are described. These processes generated carboxylic-acid-containing bromolactones in moderately high enantiomeric excesses. The results of optimization studies showed that reactions in a mixed ...
Cui Ying-Lu - - 2014
Cytochrome P450 2E1 is widely known for its ability to oxidize both low molecular weight xenobiotics and endogenous fatty acids (e.g. arachidonic acid). In this study, we investigated the structural features of the arachidonic acid-bound CYP2E1 complex utilizing molecular dynamics and found that the distinct binding modes for both arachidonic ...
Kumar Manoj M Department of Chemistry, University of Kansas, Lawrence 66045, USA. - - 2014
The tautomerization of Criegee intermediates via a 1,4 β-hydrogen atom transfer to yield a vinyl hydroperoxide has been examined in the absence and presence of carboxylic acids. Electronic structure calculations indicate that the organic acids catalyze the tautomerization reaction to such an extent that it becomes a barrierless process. In ...
Piola Lorenzo L EaStCHEM School of Chemistry, University of St Andrews, St Andrews, KY16 9ST, UK. - - 2014
An efficient and convenient ruthenium catalysed method for a regiospecific H/D exchange using D2O is described. Organic moieties such as pyridine, oxazole, imidazole, pyrazole, ester, ketone and carboxylic acid have been found effective directing groups in this transformation. In addition, the deuteration of the enantiopure (S)-Ketoprofen leads to the incorporation ...
El-Sherbeni Ahmed A AA Faculty of Pharmacy and Pharmaceutical Sciences, 2142J Katz Group-Rexall Centre for Pharmacy and Health Research, University of Alberta, Edmonton, AB, T6G 2E1, - - 2014
Epoxide hydrolases (EH) are ubiquitously expressed in all living organisms and in almost all organs and tissues. They are mainly subdivided into microsomal and soluble EH and catalyze the hydration of epoxides, three-membered-cyclic ethers, to their corresponding dihydrodiols. Owning to the high chemical reactivity of xenobiotic epoxides, microsomal EH is ...
Sipka Sándor S Division of Clinical Immunology, University of Debrecen, Debrecen, - - 2014
Enzymatic oxidation of cholesterol generates numerous distinct bile acids which function both as detergents that facilitate the digestion and absorption of dietary lipids and as hormones that activate five distinct receptors. Activation of these receptors alters gene expression in multiple tissues, leading to changes not only in bile acid metabolism ...
Arteta Marianna Yanez MY Physical Chemistry, Department of Chemistry, Lund University, P. O. Box 124, S-221 00 Lund, Sweden. - - 2014
We show for the first time that 1,2-dilauroyl-sn-glycero-3-phosphatidyladenosine nucleolipid surface complexes with cationic poly(amidoamine) dendrimers can be used to selectively bind DNA including oligonucleotides. This molecular recognition has high potential for applications involving biomedical and bioanalytic devices as well as drug delivery systems based on nucleic acids.
Zhang Lu - - 2014
This work develops an integrated microcapillary-based loop-mediated isothermal amplification (icLAMP) containing preloaded reagents and DNA extraction card, allowing for sample-to-answer screening of single nuc-leotide polymorphisms (SNPs) typing of CYP2C19 gene from untreated blood samples with minimal user operation. With all reagents and DNA extraction card preloaded inside the capillary, this ...
Pollum Marvin M Department of Chemistry and Center for Chemical Dynamics, Case Western Reserve University, 10900 Euclic Avenue, Cleveland, OH, 44106, - - 2014
The steady-state and time-resolved photochemistry of the natural nucleic acid bases and their sulfur- and nitrogen-substituted analogues in solution is reviewed. Emphasis is given to the experimental studies performed over the last 3-5 years that showcase topical areas of scientific inquiry and those that require further scrutiny. Significant progress has ...
Pflaster Erin L EL School of Biological - - 2014
Analysis of fatty acid methyl esters (FAMEs) by gas chromatography (GC) is a common technique for the quantitative and qualitative determination of acyl lipids. Methods for FAME preparation are typically time consuming and labor intensive, and require multiple transfers of reagents and products between reaction tubes and autosampler vials. In ...
Esteruelas Mireia M Departament de Bioquímica i Biotecnologia, Facultat d'Enologia de Tarragona, Grup de Recerca en Tecnologia Enològica (Tecnenol), Universitat Rovira i Virgili, Campus de Sescelades, c/Marcel.li Domingo s/n, 43007, Tarragona, - - 2014
The aim of this paper is to determine the main factors that influence the foaming properties of base wines and sparkling wines and, in particular, the role played by the maturity of the grapes in the AOC cava. Macabeo, Xarel.lo, Parellada and Chardonnay grapes were harvested at two different maturity ...
Wang Weihao W Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, PR - - 2014
Poria cocos (Schw.) Wolf is widely used as a traditional Chinese medicine, and approximately 10% of traditional Chinese medicinal preparations contain this material, according to the Chinese Pharmacopoeia (2010 edition). Although the epidermis (fulingpi in Chinese, or FLP) and the inner parts (baifuling in Chinese, or BFL) of P. cocos ...
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