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Harris William S WS Sanford School of Medicine, University of South Dakota, Sioux Falls, SD; Health Diagnostic Laboratory, Inc., Richmond, VA; OmegaQuant Analytics, LLC, Sioux Falls, SD - - 2014
The once-settled roles of all dietary fatty acid classes vis-à-vis coronary heart disease (CHD) seem to be under fire these days. For decades it had been received wisdom that "saturated fats are bad," and that margarines should replace butter to reduce risk for heart attacks. But a recent Time magazine ...
Koeberle Andreas A Institute of Pharmacy, Friedrich-Schiller-University, Philosophenweg 14, 07743 Jena, Germany. Electronic address: - - 2014
Chemical compounds studied in this article: Curcumin (PubChem CID: 969516); epigallocatechin-3-gallate (PubChem CID: 65064); resveratrol (PubChem CID: 445154); salicylic acid (PubChem CID: 338); quercetin (PubChem CID: 5280343); prostaglandin E2 (PubChem CID: 5280360); leukotriene B4 (PubChem CID: 5280492); arachidonic acid (PubChem CID: 444899).
Hu Linhua L Department of Chemistry, ‡Department of Materials Science and Engineering, Northwestern University , Evanston, Illinois 60208, United - - 2014
Oleic acid, an 18-carbon chain fatty acid, has been widely used as a surfactant to fabricate colloidal nanocrystals. In previous work, we discovered a lamellar microemulsion strategy to fabricate sub-20 nm SrTiO3 nanocuboids using oleic acid and oleate species. Here, we demonstrate (i) the general synthesis with lamellar microemulsions of ...
Franchini Massimo M aDepartment of Transfusion Medicine and Hematology, Carlo Poma Hospital, Mantova bScientific Direction, IRCCS Ca' Granda Maggiore Policlinico Hospital Foundation, Milan, - - 2014
This review provides a summary of the most recent clinical trials evaluating the hemostatic agents for the treatment of coagulopathy associated with critical bleeding. In particular, antifibrinolytic agents (i.e., aprotinin, tranexamic and ε-aminocaproic acids), desmopressin, recombinant activated factor VII, fibrinogen and prothrombin complex concentrates are evaluated. Among the various therapeutic ...
Ho Hon Eong HE WPI-Advanced Institute for Materials Research (WPI-AIMR), Tohoku University , Sendai 980-8577, - - 2014
We have demonstrated for the first time that carboxylic acids are able to catalyze the direct hydroboration of various terminal and internal alkynes with pinacolborane without using any metal catalysts. This unprecedented catalytic hydroboration exhibits a broad functional groups compatibility, giving the corresponding alkenyl diboronates and monoboronates in good to ...
Zhang Fengge F National Engineering Research Center for Organic-based Fertilizers, Nanjing Agricultural University, Nanjing 210095, PR - - 2014
The ability to colonize on plant roots is recognized as one of the most important characteristics of the beneficial fungi Trichoderma spp. The aim of this study is to prove that the utilization of organic acids is a major trait of Trichoderma harzianum T-E5 for colonization of cucumber roots. A ...
Bejarano Eloy E Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Chanin Building Room 502, 1300 Morris Park Avenue, Bronx, NY, 10461, - - 2014
Autophagy is a catabolic pathway responsible for the maintenance of the tissue and organism homeostasis. Several amino acids regulate autophagic activity in different tissues, such as liver and muscle, but much less is known about this regulation in the brain. The lack of autophagy in neurons leads to a strong ...
Amako Tomoyuki T Department of Applied Chemistry, Faculty of Science and Engineering, Kinki University, 3-4-1 Kowakae, Higashi-Osaka, Osaka 577-8502, Japan. - - 2014
Tethering four 1- versus 2-naphthyls to the same chiral scaffold derived from tartaric acid led to oppositely signed circularly polarized luminescence (CPL) and circular dichroism (CD) in solution, which not only reveals the decisive role of the spatial arrangement of chromophores/fluorophores in determining the chiroptical behaviors but also provides us ...
Isobe Yosuke Y Laboratory for Metabolomics, RIKEN Center for Integrative Medical Sciences (IMS), 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, - - 2014
Omega-3 polyunsaturated fatty acids such as eicosapentaenoic acid and docosahexaenoic acid have beneficial effects in many inflammatory disorders. Although the mechanism of eicosapentaenoic acid and docosahexaenoic acid action is still not fully defined in molecular terms, recent studies have revealed that, during the course of acute inflammation, omega-3 polyunsaturated fatty ...
Messner J J Lehrstuhl für Chemische Reaktionstechnik der Universität Erlangen-Nürnberg (FAU), Egerlandstrasse 3, D-91058 Erlangen, Germany. - - 2014
The isomerisation reaction of 1,4-dichlorobenzene leading to the thermodynamically favoured and technically desired 1,3-dichlorobenzene has been studied comparing highly acidic chloroaluminate melts with organic imidazolium and alkali metal ions. Interestingly, the inorganic melts show much higher reactivity and full recyclability if small AlCl3 losses are compensated and the reaction is ...
Shan Letian L Institute of Orthopaedics and Traumatology, Zhejiang Chinese Medical University, No. 548 Binwen Road, Binjiang District, Hangzhou 310053, China. - - 2014
Lumbar disc herniation (LDH) is a commonly occurring disease, threatening human health and life quality. Lack of a gold standard of diagnosis has hindered the efficiency and efficacy of clinical therapy against LDH. Traditional Chinese medicine (TCM) has provided an experience-based but subjective diagnosis system for LDH, demanding objective evidence ...
Bermúdez Celina C Grupo de Espectroscopia Molecular (GEM), Edificio Quifima Laboratorios de Espectroscopia y Bioespectroscopia, Parque Científico UVa, Universidad de Valladolid, 47011 Valladolid (Spain) - - 2014
Histidine is an important natural amino acid, involved in many relevant biological processes, which, because of its physical properties, proved difficult to characterize experimentally in its neutral form. In this work, neutral histidine has been generated in the gas phase by laser ablation of solid samples and its Nε H ...
Yu Xiang X Department of Chemistry, Renmin University of China, Beijing 100872 (P. R. - - 2014
Polydopamine (PDA) generated by the oxidative self-polymerization of dopamine shows great potential for surface modification. Observed PDA nanostructures are nanoparticles and thin films. The formation mechanism of PDA is still unclear; thus, the manipulation of PDA nanostructures is a big challenge. In this study, we first demonstrated that folic acid ...
Gajzlerska Wanda W Medical University of Warsaw, Department of Drug Technology & Pharmaceutical Biotechnology, Banacha 1a, Warszawa 02-097, Poland. Electronic address: - - 2014
Tacrolimus, a 23-membered polyketide macrolide, is isolated as a metabolite from the whole fermentation broth of Streptomyces species. This potent immunosuppressive calcineurin inhibitor has been widely used in various fields of medicine, including transplantology, dermatology and pharmacotherapy of autoimmune diseases. The current study was focused on optimisation of tacrolimus biosynthesis ...
Giuffrida Alessandro A Institute of Biostructure and Bioimaging, National Research Council (CNR), via P. Gaifami 18, 95126 Catania, Italy. Electronic address: - - 2014
This review highlights recent progresses in the chiral recognition and separation of amino acid enantiomers obtained by capillary electromigration techniques, using different chiral selectors and especially cyclodextrins, covering the literature published from January 2010 to March 2014. Sections are dedicated to the use of derivatization reagents and to the possibility ...
Ostergaard Jesper J Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark. Electronic address: - - 2014
Variable dissolution from sodium salts of drugs containing a carboxylic acid group after passing the acidic environment of the stomach may affect oral bioavailability. The aim of the present proof of concept study was to investigate pH effects in relation to the dissolution of sodium naproxenate in 0.01M hydrochloric acid. ...
Schleeh Thomas T Environment and Agro-biotechnologies Department, Centre de Recherche Public-Gabriel Lippmann, 41 rue du Brill, L-4422 Belvaux, Luxembourg. Electronic address: - - 2014
The adaptation of alginates to food and pharmaceutical specifications is limited to aqueous chemistry due to the insolubility of sodium alginate (Na-Alg) and the insufficient solubility of tetrabutylammonium alginate (TBA-Alg) in organic solvents. In the present investigation, these restrictions were resolved by optimizing the solubility of TBA-Alg by improving its ...
Jabeur Hazem H Laboratoire d'Électrochimie et Environnement, École Nationale d'Ingénieurs de Sfax, Université de Sfax, BP «1173», 3038 Sfax, - - 2015
The present paper accounts for the study of the storage of Chemlali olive fruits at two conditions of limited aerobiosis: in closed plastic bags and in open perforated plastic boxes for different periods before oil extraction. The ultimate objective is to investigate the effect of the container type of the ...
Quifer-Rada Paola P Department of Nutrition and Food Science-XARTA-INSA, School of Pharmacy, Campus de l'Alimentació Torribera, University of Barcelona, Barcelona, Spain; CIBER Physiopathology of Obesity and Nutrition (CIBEROBN), Institute of Health Carlos III, - - 2015
Beer is the second most consumed alcoholic beverage in Europe and shown by the European Prospective Investigation into Cancer and Nutrition cohort study to be the main food contributor to hydroxybenzoic acid intake. About 70-80% of the total polyphenol content in beer comes from malt, and the remaining 30-20% from ...
Bouteldja Nadia N Department of Radiology, Hospital of Southwest Denmark, 6700 Esbjerg, - - 2014
Ketone bodies - 3-hydroxybutyrate and acetoacetate - are important fuel substrates, which can be oxidized by most tissues in the body. They are synthesized in the liver and are derived from fatty acids released from adipose tissue. Intriguingly, under conditions of stress such as fasting, arterio-venous catheterization studies have shown ...
Sweeney Timothy E TE Stanford University, Department of General Surgery, Section of Bariatric and Minimally Invasive (BMI) Surgery, 300 Pasteur Drive, H3680, Stanford, CA 94025, - - 2014
Obesity and type 2 diabetes remain epidemic problems. Different bariatric surgical techniques causes weight loss and diabetes remission to varying degrees. The underlying mechanisms of the beneficial effects of bariatric surgery are complex, and include changes in diet and behaviour, as well as changes in hormones, bile acid flow, and ...
Jang Jong Geol JG Division of Pulmonology and Critical Care Medicine, Department of Internal Medicine, Yeungnam University College of Medicine, Daegu, - - 2014
Hyaluronic acid is widely used in medical procedures, particularly in cosmetic procedures administered by physicians or nonmedical personnel. The materials used for cosmetic procedures by physicians as well as illegally by non-medical personnel can cause nonthrombotic pulmonary embolism (NTPE). We report the case of a woman with acute respiratory failure, ...
Haque Md Mominul MM Department of Chemistry and Biomolecular Sciences, Macquarie University, Sydney, NSW 2109, - - 2014
In this paper, we demonstrate conducting polypyrrole films as a potential green technology for electrochemical treatment of azo dyes in wastewaters using Acid Red 1 as a model analyte. These films were synthesised by anodically polymerising pyrrole in the presence of Acid Red 1 as a supporting electrolyte. In this ...
Oettl Sarah K SK Institute of Pharmacy/Pharmacognosy, Center for Molecular Biosciences Innsbruck, University of Innsbruck, Innrain 80-82, 6020 Innsbruck, - - 2014
Lichens produce a diversity of secondary metabolites, among them depsides comprised of two or more hydroxybenzoic acid units linked by ester, ether, or CC-bonds. During classic solid support-based purification processes, depsides are often hydrolyzed and in many cases time, consuming procedures result only in the isolation of decomposition products. In ...
Käpylä Elli E Department of Electronics and Communications Engineering, Tampere University of Technology, P.O. Box 692, 33101 Tampere, Finland; BioMediTech, Biokatu 10, 33520 Tampere, Finland. Electronic address: - - 2014
The additive manufacturing technique of direct laser writing by two-photon polymerization (2PP-DLW) enables the fabrication of three-dimensional microstructures with superior accuracy and flexibility. When combined with biomimetic hydrogel materials, 2PP-DLW can be used to recreate the microarchitectures of the extracellular matrix. However, there are currently only a limited number of ...
Brannan Robert G RG School of Applied Health Sciences and Wellness, Ohio University, E334 Grover Center, Athens, OH 45701, United States. Electronic address: - - 2015
Pawpaw (Asimina triloba [L.] Dunal) is a tree fruit with the potential to become a high-value fruit crop, however, its rapid perishability is a significant obstacle. The objective was to determine the phytochemical content and quality characteristics of pawpaw pulp from ten varieties. This study reports for the first time ...
Passo Tsamo Claudine Valérie CV Institut des Sciences de la Vie, UCLouvain, 1348 Louvain-la-Neuve, Belgium; Centre for Food and Nutrition Research, Institute of Medical Research and Medicinal Plant Studies, P.O. Box 6163, Yaounde, - - 2015
The present study investigated the phenolic profiles of the pulp and peel of nine plantain cultivars and compared them to those of two dessert bananas of commercial interest (Grand Nain and Gros Michel), alongside a newly created hybrid, resistant to black sigatoka disease (F568). Identification and quantification of phenolic compounds ...
Al Mahmood Ammar M AM Division of Anterior Segment, Dhahran Eye Specialist Hospital, Dhahran, Saudi - - 2014
Dry eye is a common condition that can severely impair the quality of life. Systemic and topical omega-3 fatty acids and omega-6 fatty acids have been used as treatment for patients with dry eye disease and showed promising results. Further multicenter randomized controlled trials are required in order to establish ...
Ruiz Antonieta A Instrumental Analysis Department, Faculty of Pharmacy, University of Concepción, PO Box 160-C, Concepción, Chile; Department of Chemical Sciences and Natural resources, University of La Frontera, Casilla 54-D, Temuco, - - 2015
Diverse edible berries are native to the Patagonian region of Southern Chile. These berries are underused because their nutritional properties are relatively unknown. In this work, the profiles and concentrations of hydroxycinnamic acid derivatives and flavonols, and the antioxidant capacity of the berry extracts, were studied using HPLC-DAD-ESI-MS/MS and CUPRAC ...
Jeengar Manish Kumar MK Department of Pharmacology & Toxicology, National Institute of Pharmaceutical Education & Research (NIPER-Hyderabad), Balanagar, - - 2015
Emu (Dromaius novaehallandiae), the flightless bird native to Australia and found in many countries, is receiving much attention for its nutritional benefits as well as its medicinal value. Emu oil contains high amounts of polyunsaturated fatty acids and antioxidants. It has potent anti-inflammatory actions and thus can be used topically ...
Novoa-Díaz D D Sensor Systems Group, Department of Electronic Engineering, Universitat Politècnica de Catalunya, Jordi Girona 1-3, 08034 Barcelona, - - 2014
The progress of malolactic fermentation in red wines has been monitored by using ultrasonic techniques. The evolution of ultrasonic velocity of a tone burst 1MHz longitudinal wave was measured, analyzed and compared to those parameters of oenological interest obtained simultaneously by analytical methods. Semi-industrial tanks were used during measurements pretending ...
de Oliveira Marcone Augusto Leal MA Grupo de Química Analítica e Quimiometria (GQAQ), Departamento de Química, Instituto de Ciências Exatas, Universidade Federal de Juiz de Fora, Juiz de Fora, MG 36036-900, Brazil. - - 2014
A review taking into account the literature reports covering 20 years of fatty acid analysis by capillary electrophoresis is presented. This paper describes the evolution of fatty acid analysis using different CE modes such as capillary zone electrophoresis, non-aqueous capillary electrophoresis, micellar electrokinetic capillary chromatography and microemulsion electrokinetic chromatography employing ...
Garg Bhaskar B Department of Chemistry, National Tsing Hua University, Hsinchu 30013, Taiwan. - - 2014
Acid catalysis is quite prevalent and probably one of the most routine operations in both industrial processes and research laboratories worldwide. Recently, "graphene", a two dimensional single-layer carbon sheet with hexagonal packed lattice structure, imitative of nanomaterials, has shown great potential as alternative and eco-friendly solid carbocatalyst for a variety ...
Adamska Agata A Szkoła Główna Gospodarstwa Wiejskiego w Warszawie, Wydział Nauk o Żywieniu Człowieka i Konsumpcji, Zakład Analiz Instrumentalnych w - - 2014
This review analyzes the current state of knowledge on odd- and branched-chain fatty acids present in milk fat. Special attention is devoted to the characteristic, synthesis in ruminants, factors affecting their content in milk fat and pro-health properties of these compounds. The group of odd- and branched-chain fatty acids includes ...
Watterson Kenneth R KR Molecular Pharmacology Group, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow , Glasgow , - - 2014
Dietary free fatty acids (FFAs), such as ω-3 fatty acids, regulate metabolic and anti-inflammatory processes, with many of these effects attributed to FFAs interacting with a family of G protein-coupled receptors. Selective synthetic ligands for free fatty acid receptors (FFA1-4) have consequently been developed as potential treatments for type 2 ...
Zhou Yongjin J YJ Department of Chemical and Biological Engineering, Chalmers University of Technology , Gothenburg , - - 2014
Volatile energy costs and environmental concerns have spurred interest in the development of alternative, renewable, sustainable, and cost-effective energy resources. Environment-friendly processes involving microbes can be used to synthesize advanced biofuels. These fuels have the potential to replace fossil fuels in supporting high-power demanding machinery such as aircrafts and trucks. ...
Knisley Debra J DJ Department of Mathematics and Statistics, East Tennessee State University, Johnson City, TN 37614 ; Institute for Quantitative Biology, East Tennessee State University, Johnson City, TN - - 2014
We represent the protein structure of scTIM with a graph-theoretic model. We construct a hierarchical graph with three layers - a top level, a midlevel and a bottom level. The top level graph is a representation of the protein in which its vertices each represent a substructure of the protein. ...
Kim Keunsoo K Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Rd, La Jolla, CA 92037, - - 2014
IsoGNA, an isomer of glycerol nucleic acid GNA, is a flexible (acyclic) nucleic acid with bases directly attached to its linear backbone. IsoGNA exhibits (limited) base-pairing properties which are unique compared to other known flexible nucleic acids. Herein, we report on the details of the preparation of isoGNA phosphoramidites and ...
Ciesielski Slawomir S Department of Environmental Biotechnology University of Warmia and Mazury in Olsztyn Olsztyn Poland Department of Environmental Biotechnology, University of Warmia and Mazury in Olsztyn, Olsztyn, - - 2014
Polyhydroxyalkanoates (PHAs) can be produced by microorganisms and are a biodegradable alternative to fossil-fuel based plastics. Currently, the focus is on reducing production costs by exploring alternative substrates for PHAs production, and on producing copolymers which are less brittle than monomers. Accordingly, this study used a substrate consisting of wastewater ...
Sharninghausen Liam S LS Department of Chemistry, Yale University, 225 Prospect Street, New Haven, Connecticut 06520, - - 2014
The availability of glycerol is rapidly increasing due to the expanding biodiesel industry, which produces this polyol as the main waste material. Several value-added chemicals have been synthesized using glycerol as a feedstock; however, the conversion of glycerol to lactic acid has been investigated to a lesser extent despite the ...
Moran-Reyna Aida A Department of Biology, University of Alabama at Birmingham, Birmingham, AL, 35294-1170, - - 2014
The halophilic archaea (haloarchaea) live in saline environments, which are found across the globe.  In addition to salinity, these niches can be quite dynamic and experience extreme conditions such as low oxygen content, radiation (gamma and UV), pH and temperature.  However, of all the naturally occurring stresses faced by the ...
Rauschert Sebastian S Division of Metabolic and Nutritional Medicine, Dr. von Hauner Children's Hospital, Ludwig Maximilian University of Munich, Munich, - - 2014
The prevalence and incidence of obesity have become a major public health problem during the last decades, but the underlying biochemical and metabolic processes are not fully understood. Metabolomics, the science of small molecules of the metabolism, is helping to unravel these mechanisms via the identification of markers related to ...
Arlia-Ciommo Anthony A Department of Biology, Concordia University, 7141 Sherbrooke Street, West, SP Building, Room 501-13, Montreal, QC H4B 1R6, Canada. - - 2014
Bile acids are cholesterol-derived bioactive lipids that play essential roles in the maintenance of a heathy lifespan. These amphipathic molecules with detergent-like properties display numerous beneficial effects on various longevity- and healthspan-promoting processes in evolutionarily distant organisms. Recent studies revealed that lithocholic bile acid not only causes a considerable lifespan ...
Ibáñez Ana B AB Energy Biosciences Institute, University of California, Berkeley, CA 94720 - - 2014
For the development of lignocellulosic biofuels a common strategy to release hemicellulosic sugars and enhance the enzymatic digestibility of cellulose is the heat pretreatment of biomass with dilute acid. During this process, fermentation inhibitors such as 5-hydroxymethylfurfural, furfural, phenolics, and organic acids are formed and released into the so-called hydrolysate. ...
Sant'Anna Rafaela T P RT Instituto de Química, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, - - 2014
A new clock reaction based on chlorate, iodine and nitrous acid is presented. The induction period of this new clock reaction decreases when the initial concentrations of chlorate, nitrous acid and perchloric acid increase, but it is independent on the initial iodine concentration. The proposed mechanism is based on the ...
Chen Jiezhong J 1 School of Biomedical Sciences, University of Queensland, St Lucia, QLD 4072, Australia ; 2 Centre for Kidney Disease-Venomics Research, School of Medicine, University of Queensland, Princess Alexandra Hospital, Woolloongabba, Brisbane, QLD 4102, - - 2014
CYP3A4 is a major cytochrome P450. It catalyses a broad range of substrates including xenobiotics such as clinically used drugs and endogenous compounds bile acids. Its function to detoxify bile acids could be used for treating cholestasis, which is a condition characterised by accumulation of bile acids. Although bile acids ...
Yang Gang G College of Resources and Environment &Chongqing Key Laboratory of Soil Multi-scale Interfacial Process, Southwest University, 400715, Chongqing, - - 2014
Defects are often considered as the active sites for chemical reactions. Here a variety of defects in zeolites are used to stabilize zwitterionic glycine that is not self-stable in gas phase; in addition, effects of acidic strengths and zeolite channels on zwitterionic stabilization are demonstrated. Glycine zwitterions can be stabilized ...
Chouinard-Watkins Raphaël R Research Center on Aging, Health and Social Services Centre-University Institute of Geriatrics of Sherbrooke, Department of medicine, Université de Sherbrooke, 1036 Belvédère Sud, Sherbrooke, J1H 4C4, Canada. - - 2014
Apolipoprotein E (ApoE) is a protein playing a pivotal role in lipid homeostasis since it regulates cholesterol, triglyceride and phospholipid metabolism in the blood and the brain. APOE gene regulates the expression of this protein and has three different alleles: ε2, ε3 and ε4. Carrying an APOE4 allele is recognised ...
Jiang Liying L Department of Analytical Chemistry, Stockholm University, SE-106 91 Stockholm, - - 2014
Building on previous research on the origin and homochirality of life, this study focuses on analyses profiling important building blocks of life: the natural amino acids. The spark discharge variation of the iconic Miller experiment was performed with a reducing gas mixture of ammonia, methane, water and hydrogen. Amino acid ...
Araújo Wagner L WL Departamento de Biologia Vegetal, Universidade Federal de Viçosa Viçosa, Brazil ; Max-Planck Partner Group at the Departamento de Biologia Vegetal, Universidade Federal de Viçosa Viçosa, - - 2014
The tricarboxylic acid (TCA) cycle intermediate 2-oxoglutarate (2-OG) is used as an obligatory substrate in a range of oxidative reactions catalyzed by 2-OG-dependent dioxygenases. These enzymes are widespread in nature being involved in several important biochemical processes. We have recently demonstrated that tomato plants in which the TCA cycle enzyme ...
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