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Results 201 - 250 of 677
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José Marco V MV Theoretical Biology Group, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, México D.F. 04510, Mexico. - - 2014
Three-dimensional algebraic models, also called Genetic Hotels, are developed to represent the Standard Genetic Code, the Standard tRNA Code (S-tRNA-C), and the Human tRNA code (H-tRNA-C). New algebraic concepts are introduced to be able to describe these models, to wit, the generalization of the 2n-Klein Group and the concept of ...
Nguyen Thuy T TT Department of Pharmacology, Vanderbilt University Medical Center, Nashville, - - 2014
Oxidative stress has been implicated in the development of a wide variety of disease processes, including cardiovascular disease, cancer, and neurodegenerative diseases, as well as progressive and normal aging processes. Isoprostanes (IsoPs) are prostaglandin-like compounds that are generated in vivo from lipid peroxidation of arachidonic acid (AA, C20:4, ω-6) and ...
Makaen Johnson J Zoonoses and Neglected Diseases, Environmental and Emerging Diseases Unit, PNG Institute of Medical Research, Goroka, EHP, Papua New Guinea johnson.makaen@pngimr.org.pg - - 2014
The conventional method of processing sputum for acid fast bacilli microscopy has been a primary tool for laboratory diagnosis of pulmonary tuberculosis in Papua New Guinea. In routine preparation, untreated sputum is directly smeared on a glass slide without undergoing any stage of processing. Mounting evidence suggests that direct smearing ...
Białek Agnieszka A Zakład Bromatologii, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej, Warszawski Uniwersytet - - 2014
Polyunsaturated fatty acids (PUFA) have a wide range of biological activity. Among them conjugated fatty acids are of great interest. Conjugated linoleic acids (CLA), which exert a multidirectional health-benefiting influence, and conjugated linolenic acids (CLnA, super CLA) are examples of this group of fatty acids. CLnA are a group of ...
Lacina Karel K CEITEC, Masaryk University, Kamenice 5, 62500 Brno, Czech Republic ; Department of Chemistry, University of Bath, Claverton Down, Bath, BA2 7AY - - 2014
Boronic acids are increasingly utilised in diverse areas of research. Including the interactions of boronic acids with diols and strong Lewis bases as fluoride or cyanide anions, which leads to their utility in various sensing applications. The sensing applications can be homogeneous assays or heterogeneous detection. Detection can be at ...
- - 2014
[This corrects the article DOI: 10.1371/journal.pone.0101665.].
Wang Dongjie D Medical Education Center, Langfang Health Vocational College, 065001. Langfang, Heibei Province, - - 2014
The Kidney has been the target organ for the delivery of silencing ribonucleic acids (silencing RNA) administered systemically in comparison to other body tissues. In this review, we discussed different approaches made to delivering proteins to the kidneys in different conditions like normal and pathological defects. Data from clinical experiments ...
Matthessen Roman R Centre for Surface Chemistry and Catalysis, KU Leuven, Arenbergpark 23, B-3001 Leuven, - - 2014
The near-unlimited availability of CO2 has stimulated a growing research effort in creating value-added products from this greenhouse gas. This paper presents the trends on the most important methods used in the electrochemical synthesis of carboxylic acids from carbon dioxide. An overview is given of different substrate groups which form ...
Laurence Jennifer S JS Department of Pharmaceutical Chemistry, University of Kansas, Lawrence, KS, - - 2014
Metabolic activity of the oral microbiota leads to acidification of the microenvironment and promotes demineralization of tooth structure at the margin of composite restorations. The pathogenic impact of the biofilm at the margin of the composite restoration could be reduced by engineering novel dentin adhesives that neutralize the acidic micro-environment. ...
Liu Jiajie J Department of Human Health & Nutritional Sciences, College of Biological Sciences, University of Guelph, Guelph, ON N1G 2W1, Canada. - - 2014
Breast cancer (BC) is the most common cancer among women worldwide. Dietary fatty acids, especially n-3 polyunsaturated fatty acids (PUFA), are believed to play a role in reducing BC risk. Evidence has shown that fish consumption or intake of long-chain n-3 PUFA, such as eicosapentaenoic acid (EPA) and docosahexaenoic acid ...
Neuberg Patrick P Laboratoire "Vecteurs: Synthèse et Applications Thérapeutiques", UMR7199 CNRS-Université de Strasbourg, Faculté de Pharmacie, Illkirch, - - 2014
Polyethylenimines (PEIs) have proven to be highly efficient and versatile agents for nucleic acid delivery in vitro and in vivo. Despite the low biodegradability of these polymers, they have been used in several clinical trials and the results suggest that the nucleic acid/PEI complexes have a good safety profile. The high transfection ...
Wagner Ernst E Pharmaceutical Biotechnology, Department of Pharmacy, Ludwig-Maximilians-University Munich, and Nanosystems Initiative Munich (NIM), Munich, - - 2014
For the last five decades cationic polymers have been used for nucleic acids transfection. Our understanding of polymer-nucleic acid interactions and their rational use in delivery has continuously increased. The great improvements in macromolecular chemistry and the recognition of distinct biological extra- and intracellular delivery hurdles triggered several breakthrough developments, ...
Sato Yusuke Y Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo City, Hokkaido, - - 2014
It is anticipated that nucleic acid medicines will be in widespread use in the future, since they have the potential to cure diseases based on molecular mechanisms at the level of gene expression. However, intelligent delivery systems are required to achieve nucleic acid therapy, since they can perform their function ...
Ichimura Atsuhiko A Department of Pharmacogenomics, Kyoto University Graduate School of Pharmaceutical Science , Kyoto, Japan ; Department of Molecular Medicine and Therapy, Tohoku University Graduate School of Medicine , Sendai, Miyagi, - - 2014
Nutrition regulates energy balance; however, dysfunction of energy balance can cause metabolic disorders, such as obesity and diabetes. Fatty acids are an essential energy source and signaling molecules that regulate various cellular processes and physiological functions. Recently, several orphan G protein-coupled receptors were identified as free fatty acid receptors (FFARs). ...
Saunders Angela V AV Corporate Nutrition, Sanitarium Health and Wellbeing, Berkeley Vale, NSW, Australia. - - 2013
While intakes of the omega-3 fatty acid 𝛼-linolenic acid (ALA) are similar in vegetarians and non-vegetarians, intakes of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are low in vegetarians and virtually absent in vegans. Plasma, blood and tissue levels of EPA and DHA are lower in vegetarians than in non-vegetarians, although ...
Morawetz Jeffery J JJ Rancho Santa Ana Botanic Garden, 1500 N. College Avenue, Claremont, California 91711 - - 2013
• Due to lack of success in clearing whole tissues using only classical clearing techniques (e.g., Herr's 4½ solution, KOH, NaOH, lactic acid saturated with chloral hydrate), and because tissue degradation is often a result of harsh clearing agents (e.g., KOH, NaOH), a novel combined treatment was sought to improve ...
Song Cai C Chinese Academy Engineering Institute for the Development of Endangered Medicinal Resources in Southwest China, Guangxi Botanic Garden of Medicinal Plants, Nanning, Guangxi, PR - - 2013
In the last two decades, many studies have demonstrated that increased inflammatory responses occur in patients with affective disorders, which could contribute to the dysfunction of neuroendocrine and neurotransmission in these diseases. The evidence consequently suggests that drugs or natural products with anti-inflammatory properties should be developed to treat the ...
Aguilera Angeles A Astrobiology Center, Spanish Institute for Aerospace Technologies, Carretera de Ajalvir Km 4, Torrejón de Ardoz, 28850 Madrid, Spain. - - 2013
A major issue in microbial ecology is to identify the limits of life for growth and survival, and to understand the molecular mechanisms that define these limits. Thus, interest in the biodiversity and ecology of extreme environments has grown in recent years for several reasons. Some are basic and revolve ...
Tang Lirong - - 2012
Esterified cellulose nanocrystals (E-CNCs) are cellulose derivatives that could be applied in biomedical and chemical industries. E-CNCs were prepared with cellulose pulp using a mixture of 17.5M acetic and 18.4M sulfuric acid with the aid of ultrasonication. The effects of esterification time (3-7h), ultrasonication time (with a frequency of 40kHz, ...
Passos Priscila Pereira - - 2012
Essential fatty acids play a crucial role in the activity of several neurotransmission systems, especially in the monoaminergic systems involved in cognitive and motor aspects of behavior. The present study investigated whether essential fatty acid dietary restriction over two generations could differentially affect dopaminergic cell populations located in the substantia ...
Martin Melanie A MA Integrative Anthropological Sciences, University of California Santa Barbara, Santa Barbara, California 93106-3210, USA. - - 2012
Breast milk fatty acid (FA) composition varies greatly among individual women, including in percentages of the long-chain polyunsaturated FAs (LCPUFA) 20:4n-6 (arachidonic acid, AA) and 22:6n-3 (docosahexaenoic acid, DHA), which are important for infant neurological development. It has been suggested that owing to wide variation in milk LCPUFA and low ...
Saga Linda C - - 2012
This study investigated data obtained from whole blood fatty acid (FA) composition of 3476 Norwegian and Swedish individuals, which provided background information including age, gender, nationality and self-motivated n-3 supplement consumption. The aim of this paper was to statistically relate this background information on the subjects to their whole blood ...
Kaur Narinder N Department of Biochemistry, Punjab Agricultural University, Ludhiana, 141004 - - 2014
During the recent decades, awareness towards the role of essential fatty acids in human health and disease prevention has been unremittingly increasing among people. Fish, fish oils and some vegetable oils are rich sources of essential fatty acids. Many studies have positively correlated essential fatty acids with reduction of cardiovascular ...
Yokota S - - 2012
The fatty acid synthase (FASN) and stearoyl-CoA desaturase (delta-9-desaturase) (SCD) genes affect fatty acid composition. This study evaluated the contributions of polymorphisms of these genes on fatty acid composition in muscle in two different populations: 1189 and 1058 Japanese Black cattle from the Miyagi and the Yamagata populations respectively. We ...
Bi Hongkai H Departments of Microbiology Biochemistry, B103 Chemical and Life Sciences Laboratory, University of Illinois, 601 S. Goodwin Ave, Urbana, IL 61801, - - 2012
Signal molecules of the diffusible signal factor (DSF) family have been shown recently to be involved in regulation of pathogenesis and biofilm formation in diverse Gram-negative bacteria. DSF signals are reported to be active not only on their cognate bacteria, but also on unrelated bacteria and the pathogenic yeast, Candida ...
Wang Xiaoxu - - 2012
The transition period is a severe challenge to dairy cows. Glucose supply cannot meet demand and body fat is mobilized, potentially leading to negative energy balance (NEB), ketosis, or fatty liver. Propionate produces glucose by gluconeogenesis, which depends heavily on the number and species of microbes. In the present study, ...
Palacios-Chaves Leyre - - 2012
The brucellae are facultative intracellular pathogens of mammals that are transmitted by contact with infected animals or contaminated materials. Several major lipidic components of the Brucella cell envelope are imperfectly recognized by innate immunity thus contributing to virulence. These components carry large proportions of acyl chains of lactobacillic acid, a ...
Molla Gianluca - - 2012
D: -Amino acids play several key roles and are widely diffused in living organisms, from bacteria (in which D: -alanine is a component of the cell wall) to mammals (where D: -serine is involved in glutamatergic neurotransmission in the central nervous system). The study of the biological processes involving D: ...
Wallace John L - - 2012
The mechanisms underlying the ability of nonsteroidal anti-inflammatory drugs (NSAIDs) to cause ulceration in the stomach and proximal duodenum are well understood, and this injury can largely be prevented through suppression of gastric acid secretion (mainly with proton pump inhibitors). In contrast, the pathogenesis of small intestinal injury induced by ...
Li Robert W RW United States Department of Agriculture- Agricultural Research Service, Bovine Functional Genomics Laboratory, Beltsville, Maryland, United States of America. - - 2012
The capacity of the rumen microbiota to produce volatile fatty acids (VFAs) has important implications in animal well-being and production. We investigated temporal changes of the rumen microbiota in response to butyrate infusion using pyrosequencing of the 16S rRNA gene. Twenty one phyla were identified in the rumen microbiota of ...
Jiao Yang Y Department of Chemical Engineering & Materials Science, Stevens Institute of Technology, Hoboken, NJ 07030, - - 2012
Injectable biodegradable hydrogels, which can be delivered in a minimally invasive manner and formed in situ, have found a number of applications in pharmaceutical and biomedical applications, such as drug delivery and tissue engineering. We have recently developed an in situ crosslinkable citric acid-based biodegradable poly (ethylene glycol) maleate citrate ...
Egel Richard R Department of Biology, University of Copenhagen Biocenter, Ole Maaløes Vej 5, DK-2200 Copenhagen, Denmark. - - 2012
In memoriam Jeffrey S. Wicken (1942-2002)-the evolutionarily minded biochemist, who in the 1970/80s strived for a synthesis of biological and physical theories to fathom the tentative origins of life. Several integrative concepts are worth remembering from Wicken's legacy. (i) Connecting life's origins and complex organization to a preexisting physical world ...
Lanéelle Marie-Antoinette - - 2011
Corynebacterineae are characterized by the presence of long-chain lipids, notably mycolic acids (α-alkyl, β-hydroxy fatty acids), the structures of which are genus-specific. Mycolic acids from two environmental strains, Amycolicicoccus subflavus and Hoyosella altamirensis, were isolated and their structures established using a combination of mass spectrometry analysis, 1H-NMR spectroscopy and chemical ...
Li Wen-Juan - - 2011
The aim of this study was to investigate the possibility of ethanol-soluble acidic components (ESAC) from Ganoderma atrum as a novel source against bacteria and oxidation in food industry. The qualitative analysis of ESAC was based on liquid chromatography-mass spectrometry (LC/MS) and eight ganoderic acids were identified in ESAC. Its ...
Cui Yanhua - - 2011
The Gram-positive bacterium Lactobacillus delbrueckii subsp. bulgaricus is of vital importance to the food industry, especially to the dairy industry. Two component systems (TCSs) are one of the most important mechanisms for environmental sensing and signal transduction in the majority of Gram-positive and Gram-negative bacteria. A typical TCS consists of ...
Nyanga-Koumou Armand P - - 2011
Regulation of the cytoplasmic or internal pH (pHin) is a fundamental requirement for the survival and viability of bacteria. The optimum pHin for most bacteria is near the neutral point (pH 7.0). Therefore, bacteria may have some strategies to adapt themselves to the acidity or alkalinity of cytoplasm. As other ...
Wells A - - 2011
Aims:  To investigate the impact of acetaldehyde and pyruvic acid bound sulfur dioxide on wine lactic acid bacteria. Methods and Results:  Growth studies were performed where Oenococcus oeni, Pediococcus parvulus, P. damnosus, and Lactobacillus hilgardii were inoculated into media containing various concentrations of acetaldehyde or pyruvic acid and an equimolar ...
Fischer Carol L CL Dows Institute for Dental Research, College of Dentistry, University of Iowa, Iowa City, Iowa, - - 2012
There is growing evidence that the role of lipids in innate immunity is more important than previously realized. How lipids interact with bacteria to achieve a level of protection, however, is still poorly understood. To begin to address the mechanisms of antibacterial activity, we determined MICs and minimum bactericidal concentrations ...
Wang Jifu - - 2011
We report novel robust resin acid-derived antimicrobial agents that exhibit excellent antimicrobial activities against a broad spectrum of bacteria (6 Gram-positive and 7 Gram-negative) with selective lysis of microbial membranes over mammalian membranes. Our results indicate that hydrophobicity and unique structures of resin acids can be determining factors in dictating ...
Estrada J D - - 2011
Fortified dairy products appeal to a wide variety of consumers and have the potential to increase sales in the yogurt industry and help increase intake of long-chain n-3 fatty acids. The objectives of this study were to develop a strawberry yogurt containing microencapsulated salmon oil (MSO; 2% wt/vol) and evaluate ...
Li Ming - - 2011
An urgent need exists for HIV-1 microbicides. Here, we describe the in vivo testing of lactic acid bacteria bioengineered to secrete cyanovirin-N. We fed pigtail macaques a yogurt formulation that used bioengineered strains as a starter culture. Cyanovirin-N expression could be detected in the rectal vault during and immediately after ...
Yu Bo - - 2011
Lactobacillus rhamnosus is a type of probiotic bacteria with industrial potential for L-lactic acid production. We announce the draft genome sequence of L. rhamnosus CASL (2,855,156 bp with a G+C content of 46.6%), which is an efficient producer of L-lactic acid from cheap, nonfood substrate cassava with a high production ...
Quévrain Elodie - - 2011
The fatty acid composition of the temperate calcareous marine sponge Leuconia johnstoni Carter 1871 (Calcaronea, Calcarea) was characterized for the first time in specimens collected off the Brittany coast of France over four years from October 2005 to September 2008. Forty-one fatty acids (FA) with chain lengths ranging from C(14) to ...
de Carvalho Carla C C R - - 2011
Bioremediation of contaminated sites is rarely performed in nature under ideal growth conditions for bacteria. Extremophiles can grow at extreme values of temperature, pH, ionic strength and metal concentrations, etc., but it may be difficult to find and isolate those possessing the required metabolic activities. In the present work, Rhodococcus ...
Rizzello Carlo G - - 2011
This study aimed to exploit the potential of sourdough lactic acid bacteria to release lunasin during fermentation of cereal and nonconventional flours. The peptidase activities of a large number of sourdough lactic acid bacteria were screened using synthetic substrates. Selected lactic acid bacteria were used as sourdough starters to ferment ...
Stafford G G Oral and Maxillofacial Pathology, School of Clinical Dentistry, University of Sheffield, Sheffield, UK. - - 2012
Periodontal pathogens, like any other human commensal or pathogenic bacterium, must possess both the ability to acquire the necessary growth factors and the means to adhere to surfaces or reside and survive in their environmental niche. Recent evidence has suggested that sialic acid containing host molecules may provide both of ...
Hoyle Parks A R - - 2011
Growth of pathogenic organisms such as Escherichia coli O157:H7 and Salmonella spp. can be inhibited in ground beef though addition of certain lactic acid producing bacteria (LAB; Lactobacillus acidophilus NP51, Lactobacillus crispatus NP35, Pediococcus acidilactici, and Lactococcus lactis ssp. Lactis). This study evaluated the effects of LAB inclusion on the ...
Hino Shingo - - 2011
We evaluated the ameliorating effects of short-chain inulin-like fructans (SIF) with different degrees of polymerization (DP) on the healing stage of trinitrobenzene sulfonic acid (TNBS)-induced colitis in rats. The rats were assigned to 3 groups 10 d after the colitis induction, and fed for 24 d on a control diet ...
Dupuis Stephanie N - - 2011
Streptomyces venezuelae ISP5230 is recognized for the production of chloramphenicol and the jadomycin family of natural products. The jadomycins are angucycline natural products containing a unique oxazolone ring incorporating an amino acid present in the minimal culture media. Substitution of different amino acids results in products of varying biological activity. ...
Zanet Caio Gorgulho - - 2011
Acid erosion is a superficial loss of enamel caused by chemical processes that do not involve bacteria. Intrinsic and extrinsic factors, such as the presence of acid substances in the oral cavity, may cause a pH reduction, thus potentially increasing acid erosion. The aim of this study was to evaluate ...
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