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Mei Qingsong Q Department of Biomedical Engineering, School of Medical Engineering, Hefei University of Technology, P.O. Box 112, Tunxi road 193, Hefei, Anhui 230009, - - 2014
In this work, we reported a simple and effective upconversional nanoprobe for selective detection of hydroxyl radical (OH) and visual evaluation of OH-scavenging activities of drugs for the first time. The upconversion luminescence from NaYF4:Yb,Er nanoparticles was first quenched by carminic acid (CA) through luminescence resonance energy transfer (LRET) mechanism, ...
Giby Vettickattuparambil George VG Vettickattuparambil George Giby, Thekkuttuparambil Ananthanarayanan Ajith, Department of Biochemistry, Amala Institute of Medical Sciences, Thrissur-680 555, Kerala, - - 2014
Intrahepatic fat deposition has been demonstrated in patients with nonalcoholic fatty liver disease (NAFLD). Genetic and environmental factors are important for the development of NAFLD. Diseases such as obesity, diabetes, and hypertension have been found to be closely associated with the incidence of NAFLD. Evidence suggests that obesity and insulin ...
van der Born Dion D Department of Radiology and Nuclear Medicine, VU University Medical Center, De Boelelaan 1085c, 1081 HV Amsterdam (The - - 2014
Herein, we describe a valuable method for the introduction of the [(18) F]CF3 group into arenes with highly improved specific activity by the reaction of [(18) F]trifluoromethane with aryl iodides or aryl boronic acids. This [(18) F]trifluoromethylation reaction is the first to be described in which the [(18) F]CF3 products ...
Robertson Jeremy J Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford, OX1 3TA, UK. - - 2014
Covering: July 2001 to December 2012This review covers pyrrolizidine alkaloids isolated from natural sources. Topics include: aspects of structure, isolation, and biological/pharmacological studies; total syntheses of necic acids, necine bases and closely-related non-natural analogues.
Jiang Juncong - - 2014
Superacids, defined as acids with Hammett acidity function H0 ≤ -12, are useful materials, but a need exists for new, designable solid state systems. Here, we report superacidity in a sulfated metal-organic framework (MOF) obtained by treating the microcrystalline form of MOF-808 [MOF-808-P: Zr6O5(OH)3(BTC)2(HCOO)5, BTC = 1,3,5-benzenetricarboxylate] with aqueous sulfuric ...
Harris William S WS Sanford School of Medicine, University of South Dakota, Sioux Falls, SD; Health Diagnostic Laboratory, Inc., Richmond, VA; OmegaQuant Analytics, LLC, Sioux Falls, SD - - 2014
The once-settled roles of all dietary fatty acid classes vis-à-vis coronary heart disease (CHD) seem to be under fire these days. For decades it had been received wisdom that "saturated fats are bad," and that margarines should replace butter to reduce risk for heart attacks. But a recent Time magazine ...
Koeberle Andreas A Institute of Pharmacy, Friedrich-Schiller-University, Philosophenweg 14, 07743 Jena, Germany. Electronic address: - - 2014
Chemical compounds studied in this article: Curcumin (PubChem CID: 969516); epigallocatechin-3-gallate (PubChem CID: 65064); resveratrol (PubChem CID: 445154); salicylic acid (PubChem CID: 338); quercetin (PubChem CID: 5280343); prostaglandin E2 (PubChem CID: 5280360); leukotriene B4 (PubChem CID: 5280492); arachidonic acid (PubChem CID: 444899).
Hu Linhua L Department of Chemistry, ‡Department of Materials Science and Engineering, Northwestern University , Evanston, Illinois 60208, United - - 2014
Oleic acid, an 18-carbon chain fatty acid, has been widely used as a surfactant to fabricate colloidal nanocrystals. In previous work, we discovered a lamellar microemulsion strategy to fabricate sub-20 nm SrTiO3 nanocuboids using oleic acid and oleate species. Here, we demonstrate (i) the general synthesis with lamellar microemulsions of ...
Franchini Massimo M aDepartment of Transfusion Medicine and Hematology, Carlo Poma Hospital, Mantova bScientific Direction, IRCCS Ca' Granda Maggiore Policlinico Hospital Foundation, Milan, - - 2014
This review provides a summary of the most recent clinical trials evaluating the hemostatic agents for the treatment of coagulopathy associated with critical bleeding. In particular, antifibrinolytic agents (i.e., aprotinin, tranexamic and ε-aminocaproic acids), desmopressin, recombinant activated factor VII, fibrinogen and prothrombin complex concentrates are evaluated. Among the various therapeutic ...
Ho Hon Eong HE WPI-Advanced Institute for Materials Research (WPI-AIMR), Tohoku University , Sendai 980-8577, - - 2014
We have demonstrated for the first time that carboxylic acids are able to catalyze the direct hydroboration of various terminal and internal alkynes with pinacolborane without using any metal catalysts. This unprecedented catalytic hydroboration exhibits a broad functional groups compatibility, giving the corresponding alkenyl diboronates and monoboronates in good to ...
Zhang Fengge F National Engineering Research Center for Organic-based Fertilizers, Nanjing Agricultural University, Nanjing 210095, PR - - 2014
The ability to colonize on plant roots is recognized as one of the most important characteristics of the beneficial fungi Trichoderma spp. The aim of this study is to prove that the utilization of organic acids is a major trait of Trichoderma harzianum T-E5 for colonization of cucumber roots. A ...
Bejarano Eloy E Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Chanin Building Room 502, 1300 Morris Park Avenue, Bronx, NY, 10461, - - 2014
Autophagy is a catabolic pathway responsible for the maintenance of the tissue and organism homeostasis. Several amino acids regulate autophagic activity in different tissues, such as liver and muscle, but much less is known about this regulation in the brain. The lack of autophagy in neurons leads to a strong ...
Amako Tomoyuki T Department of Applied Chemistry, Faculty of Science and Engineering, Kinki University, 3-4-1 Kowakae, Higashi-Osaka, Osaka 577-8502, Japan. - - 2014
Tethering four 1- versus 2-naphthyls to the same chiral scaffold derived from tartaric acid led to oppositely signed circularly polarized luminescence (CPL) and circular dichroism (CD) in solution, which not only reveals the decisive role of the spatial arrangement of chromophores/fluorophores in determining the chiroptical behaviors but also provides us ...
Messner J J Lehrstuhl für Chemische Reaktionstechnik der Universität Erlangen-Nürnberg (FAU), Egerlandstrasse 3, D-91058 Erlangen, Germany. - - 2014
The isomerisation reaction of 1,4-dichlorobenzene leading to the thermodynamically favoured and technically desired 1,3-dichlorobenzene has been studied comparing highly acidic chloroaluminate melts with organic imidazolium and alkali metal ions. Interestingly, the inorganic melts show much higher reactivity and full recyclability if small AlCl3 losses are compensated and the reaction is ...
Shan Letian L Institute of Orthopaedics and Traumatology, Zhejiang Chinese Medical University, No. 548 Binwen Road, Binjiang District, Hangzhou 310053, China. - - 2014
Lumbar disc herniation (LDH) is a commonly occurring disease, threatening human health and life quality. Lack of a gold standard of diagnosis has hindered the efficiency and efficacy of clinical therapy against LDH. Traditional Chinese medicine (TCM) has provided an experience-based but subjective diagnosis system for LDH, demanding objective evidence ...
Bermúdez Celina C Grupo de Espectroscopia Molecular (GEM), Edificio Quifima Laboratorios de Espectroscopia y Bioespectroscopia, Parque Científico UVa, Universidad de Valladolid, 47011 Valladolid (Spain) - - 2014
Histidine is an important natural amino acid, involved in many relevant biological processes, which, because of its physical properties, proved difficult to characterize experimentally in its neutral form. In this work, neutral histidine has been generated in the gas phase by laser ablation of solid samples and its Nε H ...
Yu Xiang X Department of Chemistry, Renmin University of China, Beijing 100872 (P. R. - - 2014
Polydopamine (PDA) generated by the oxidative self-polymerization of dopamine shows great potential for surface modification. Observed PDA nanostructures are nanoparticles and thin films. The formation mechanism of PDA is still unclear; thus, the manipulation of PDA nanostructures is a big challenge. In this study, we first demonstrated that folic acid ...
Gajzlerska Wanda W Medical University of Warsaw, Department of Drug Technology & Pharmaceutical Biotechnology, Banacha 1a, Warszawa 02-097, Poland. Electronic address: - - 2014
Tacrolimus, a 23-membered polyketide macrolide, is isolated as a metabolite from the whole fermentation broth of Streptomyces species. This potent immunosuppressive calcineurin inhibitor has been widely used in various fields of medicine, including transplantology, dermatology and pharmacotherapy of autoimmune diseases. The current study was focused on optimisation of tacrolimus biosynthesis ...
Giuffrida Alessandro A Institute of Biostructure and Bioimaging, National Research Council (CNR), via P. Gaifami 18, 95126 Catania, Italy. Electronic address: - - 2014
This review highlights recent progresses in the chiral recognition and separation of amino acid enantiomers obtained by capillary electromigration techniques, using different chiral selectors and especially cyclodextrins, covering the literature published from January 2010 to March 2014. Sections are dedicated to the use of derivatization reagents and to the possibility ...
Ostergaard Jesper J Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark. Electronic address: - - 2014
Variable dissolution from sodium salts of drugs containing a carboxylic acid group after passing the acidic environment of the stomach may affect oral bioavailability. The aim of the present proof of concept study was to investigate pH effects in relation to the dissolution of sodium naproxenate in 0.01M hydrochloric acid. ...
Schleeh Thomas T Environment and Agro-biotechnologies Department, Centre de Recherche Public-Gabriel Lippmann, 41 rue du Brill, L-4422 Belvaux, Luxembourg. Electronic address: - - 2014
The adaptation of alginates to food and pharmaceutical specifications is limited to aqueous chemistry due to the insolubility of sodium alginate (Na-Alg) and the insufficient solubility of tetrabutylammonium alginate (TBA-Alg) in organic solvents. In the present investigation, these restrictions were resolved by optimizing the solubility of TBA-Alg by improving its ...
Jabeur Hazem H Laboratoire d'Électrochimie et Environnement, École Nationale d'Ingénieurs de Sfax, Université de Sfax, BP «1173», 3038 Sfax, - - 2015
The present paper accounts for the study of the storage of Chemlali olive fruits at two conditions of limited aerobiosis: in closed plastic bags and in open perforated plastic boxes for different periods before oil extraction. The ultimate objective is to investigate the effect of the container type of the ...
Quifer-Rada Paola P Department of Nutrition and Food Science-XARTA-INSA, School of Pharmacy, Campus de l'Alimentació Torribera, University of Barcelona, Barcelona, Spain; CIBER Physiopathology of Obesity and Nutrition (CIBEROBN), Institute of Health Carlos III, - - 2015
Beer is the second most consumed alcoholic beverage in Europe and shown by the European Prospective Investigation into Cancer and Nutrition cohort study to be the main food contributor to hydroxybenzoic acid intake. About 70-80% of the total polyphenol content in beer comes from malt, and the remaining 30-20% from ...
Bouteldja Nadia N Department of Radiology, Hospital of Southwest Denmark, 6700 Esbjerg, - - 2014
Ketone bodies - 3-hydroxybutyrate and acetoacetate - are important fuel substrates, which can be oxidized by most tissues in the body. They are synthesized in the liver and are derived from fatty acids released from adipose tissue. Intriguingly, under conditions of stress such as fasting, arterio-venous catheterization studies have shown ...
Sweeney Timothy E TE Stanford University, Department of General Surgery, Section of Bariatric and Minimally Invasive (BMI) Surgery, 300 Pasteur Drive, H3680, Stanford, CA 94025, - - 2014
Obesity and type 2 diabetes remain epidemic problems. Different bariatric surgical techniques causes weight loss and diabetes remission to varying degrees. The underlying mechanisms of the beneficial effects of bariatric surgery are complex, and include changes in diet and behaviour, as well as changes in hormones, bile acid flow, and ...
Jang Jong Geol JG Division of Pulmonology and Critical Care Medicine, Department of Internal Medicine, Yeungnam University College of Medicine, Daegu, - - 2014
Hyaluronic acid is widely used in medical procedures, particularly in cosmetic procedures administered by physicians or nonmedical personnel. The materials used for cosmetic procedures by physicians as well as illegally by non-medical personnel can cause nonthrombotic pulmonary embolism (NTPE). We report the case of a woman with acute respiratory failure, ...
Haque Md Mominul MM Department of Chemistry and Biomolecular Sciences, Macquarie University, Sydney, NSW 2109, - - 2014
In this paper, we demonstrate conducting polypyrrole films as a potential green technology for electrochemical treatment of azo dyes in wastewaters using Acid Red 1 as a model analyte. These films were synthesised by anodically polymerising pyrrole in the presence of Acid Red 1 as a supporting electrolyte. In this ...
Oettl Sarah K SK Institute of Pharmacy/Pharmacognosy, Center for Molecular Biosciences Innsbruck, University of Innsbruck, Innrain 80-82, 6020 Innsbruck, - - 2014
Lichens produce a diversity of secondary metabolites, among them depsides comprised of two or more hydroxybenzoic acid units linked by ester, ether, or CC-bonds. During classic solid support-based purification processes, depsides are often hydrolyzed and in many cases time, consuming procedures result only in the isolation of decomposition products. In ...
Käpylä Elli E Department of Electronics and Communications Engineering, Tampere University of Technology, P.O. Box 692, 33101 Tampere, Finland; BioMediTech, Biokatu 10, 33520 Tampere, Finland. Electronic address: - - 2014
The additive manufacturing technique of direct laser writing by two-photon polymerization (2PP-DLW) enables the fabrication of three-dimensional microstructures with superior accuracy and flexibility. When combined with biomimetic hydrogel materials, 2PP-DLW can be used to recreate the microarchitectures of the extracellular matrix. However, there are currently only a limited number of ...
Brannan Robert G RG School of Applied Health Sciences and Wellness, Ohio University, E334 Grover Center, Athens, OH 45701, United States. Electronic address: - - 2015
Pawpaw (Asimina triloba [L.] Dunal) is a tree fruit with the potential to become a high-value fruit crop, however, its rapid perishability is a significant obstacle. The objective was to determine the phytochemical content and quality characteristics of pawpaw pulp from ten varieties. This study reports for the first time ...
Passo Tsamo Claudine Valérie CV Institut des Sciences de la Vie, UCLouvain, 1348 Louvain-la-Neuve, Belgium; Centre for Food and Nutrition Research, Institute of Medical Research and Medicinal Plant Studies, P.O. Box 6163, Yaounde, - - 2015
The present study investigated the phenolic profiles of the pulp and peel of nine plantain cultivars and compared them to those of two dessert bananas of commercial interest (Grand Nain and Gros Michel), alongside a newly created hybrid, resistant to black sigatoka disease (F568). Identification and quantification of phenolic compounds ...
Ruiz Antonieta A Instrumental Analysis Department, Faculty of Pharmacy, University of Concepción, PO Box 160-C, Concepción, Chile; Department of Chemical Sciences and Natural resources, University of La Frontera, Casilla 54-D, Temuco, - - 2015
Diverse edible berries are native to the Patagonian region of Southern Chile. These berries are underused because their nutritional properties are relatively unknown. In this work, the profiles and concentrations of hydroxycinnamic acid derivatives and flavonols, and the antioxidant capacity of the berry extracts, were studied using HPLC-DAD-ESI-MS/MS and CUPRAC ...
Novoa-Díaz D D Sensor Systems Group, Department of Electronic Engineering, Universitat Politècnica de Catalunya, Jordi Girona 1-3, 08034 Barcelona, - - 2014
The progress of malolactic fermentation in red wines has been monitored by using ultrasonic techniques. The evolution of ultrasonic velocity of a tone burst 1MHz longitudinal wave was measured, analyzed and compared to those parameters of oenological interest obtained simultaneously by analytical methods. Semi-industrial tanks were used during measurements pretending ...
- - 2014
[This corrects the article DOI: 10.1371/journal.pone.0099376.].
de Oliveira Marcone Augusto Leal MA Grupo de Química Analítica e Quimiometria (GQAQ), Departamento de Química, Instituto de Ciências Exatas, Universidade Federal de Juiz de Fora, Juiz de Fora, MG 36036-900, Brazil. - - 2014
A review taking into account the literature reports covering 20 years of fatty acid analysis by capillary electrophoresis is presented. This paper describes the evolution of fatty acid analysis using different CE modes such as capillary zone electrophoresis, non-aqueous capillary electrophoresis, micellar electrokinetic capillary chromatography and microemulsion electrokinetic chromatography employing ...
Garg Bhaskar B Department of Chemistry, National Tsing Hua University, Hsinchu 30013, Taiwan. - - 2014
Acid catalysis is quite prevalent and probably one of the most routine operations in both industrial processes and research laboratories worldwide. Recently, "graphene", a two dimensional single-layer carbon sheet with hexagonal packed lattice structure, imitative of nanomaterials, has shown great potential as alternative and eco-friendly solid carbocatalyst for a variety ...
Adamska Agata A Szkoła Główna Gospodarstwa Wiejskiego w Warszawie, Wydział Nauk o Żywieniu Człowieka i Konsumpcji, Zakład Analiz Instrumentalnych w - - 2014
This review analyzes the current state of knowledge on odd- and branched-chain fatty acids present in milk fat. Special attention is devoted to the characteristic, synthesis in ruminants, factors affecting their content in milk fat and pro-health properties of these compounds. The group of odd- and branched-chain fatty acids includes ...
Watterson Kenneth R KR Molecular Pharmacology Group, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow , Glasgow , - - 2014
Dietary free fatty acids (FFAs), such as ω-3 fatty acids, regulate metabolic and anti-inflammatory processes, with many of these effects attributed to FFAs interacting with a family of G protein-coupled receptors. Selective synthetic ligands for free fatty acid receptors (FFA1-4) have consequently been developed as potential treatments for type 2 ...
Zhou Yongjin J YJ Department of Chemical and Biological Engineering, Chalmers University of Technology , Gothenburg , - - 2014
Volatile energy costs and environmental concerns have spurred interest in the development of alternative, renewable, sustainable, and cost-effective energy resources. Environment-friendly processes involving microbes can be used to synthesize advanced biofuels. These fuels have the potential to replace fossil fuels in supporting high-power demanding machinery such as aircrafts and trucks. ...
Arlia-Ciommo Anthony A Department of Biology, Concordia University, 7141 Sherbrooke Street, West, SP Building, Room 501-13, Montreal, QC H4B 1R6, Canada. - - 2014
Bile acids are cholesterol-derived bioactive lipids that play essential roles in the maintenance of a heathy lifespan. These amphipathic molecules with detergent-like properties display numerous beneficial effects on various longevity- and healthspan-promoting processes in evolutionarily distant organisms. Recent studies revealed that lithocholic bile acid not only causes a considerable lifespan ...
Knisley Debra J DJ Department of Mathematics and Statistics, East Tennessee State University, Johnson City, TN 37614 ; Institute for Quantitative Biology, East Tennessee State University, Johnson City, TN - - 2014
We represent the protein structure of scTIM with a graph-theoretic model. We construct a hierarchical graph with three layers - a top level, a midlevel and a bottom level. The top level graph is a representation of the protein in which its vertices each represent a substructure of the protein. ...
Kim Keunsoo K Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Rd, La Jolla, CA 92037, - - 2014
IsoGNA, an isomer of glycerol nucleic acid GNA, is a flexible (acyclic) nucleic acid with bases directly attached to its linear backbone. IsoGNA exhibits (limited) base-pairing properties which are unique compared to other known flexible nucleic acids. Herein, we report on the details of the preparation of isoGNA phosphoramidites and ...
Ciesielski Slawomir S Department of Environmental Biotechnology University of Warmia and Mazury in Olsztyn Olsztyn Poland Department of Environmental Biotechnology, University of Warmia and Mazury in Olsztyn, Olsztyn, - - 2014
Polyhydroxyalkanoates (PHAs) can be produced by microorganisms and are a biodegradable alternative to fossil-fuel based plastics. Currently, the focus is on reducing production costs by exploring alternative substrates for PHAs production, and on producing copolymers which are less brittle than monomers. Accordingly, this study used a substrate consisting of wastewater ...
Morawetz Jeffery J JJ Rancho Santa Ana Botanic Garden, 1500 N. College Avenue, Claremont, California 91711 - - 2013
• Due to lack of success in clearing whole tissues using only classical clearing techniques (e.g., Herr's 4½ solution, KOH, NaOH, lactic acid saturated with chloral hydrate), and because tissue degradation is often a result of harsh clearing agents (e.g., KOH, NaOH), a novel combined treatment was sought to improve ...
Song Cai C Chinese Academy Engineering Institute for the Development of Endangered Medicinal Resources in Southwest China, Guangxi Botanic Garden of Medicinal Plants, Nanning, Guangxi, PR - - 2013
In the last two decades, many studies have demonstrated that increased inflammatory responses occur in patients with affective disorders, which could contribute to the dysfunction of neuroendocrine and neurotransmission in these diseases. The evidence consequently suggests that drugs or natural products with anti-inflammatory properties should be developed to treat the ...
Tang Lirong - - 2012
Esterified cellulose nanocrystals (E-CNCs) are cellulose derivatives that could be applied in biomedical and chemical industries. E-CNCs were prepared with cellulose pulp using a mixture of 17.5M acetic and 18.4M sulfuric acid with the aid of ultrasonication. The effects of esterification time (3-7h), ultrasonication time (with a frequency of 40kHz, ...
Passos Priscila Pereira - - 2012
Essential fatty acids play a crucial role in the activity of several neurotransmission systems, especially in the monoaminergic systems involved in cognitive and motor aspects of behavior. The present study investigated whether essential fatty acid dietary restriction over two generations could differentially affect dopaminergic cell populations located in the substantia ...
Martin Melanie A MA Integrative Anthropological Sciences, University of California Santa Barbara, Santa Barbara, California 93106-3210, USA. - - 2012
Breast milk fatty acid (FA) composition varies greatly among individual women, including in percentages of the long-chain polyunsaturated FAs (LCPUFA) 20:4n-6 (arachidonic acid, AA) and 22:6n-3 (docosahexaenoic acid, DHA), which are important for infant neurological development. It has been suggested that owing to wide variation in milk LCPUFA and low ...
Saga Linda C - - 2012
This study investigated data obtained from whole blood fatty acid (FA) composition of 3476 Norwegian and Swedish individuals, which provided background information including age, gender, nationality and self-motivated n-3 supplement consumption. The aim of this paper was to statistically relate this background information on the subjects to their whole blood ...
Yokota S - - 2012
The fatty acid synthase (FASN) and stearoyl-CoA desaturase (delta-9-desaturase) (SCD) genes affect fatty acid composition. This study evaluated the contributions of polymorphisms of these genes on fatty acid composition in muscle in two different populations: 1189 and 1058 Japanese Black cattle from the Miyagi and the Yamagata populations respectively. We ...
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