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Mehdi Mohammad Murtaza MM Department of Biochemistry, University of Allahabad, Allahabad, - - 2012
Sialic acids are substituted neuraminic acid derivatives which are typically found at the outermost end of glycan chains on the membrane in all cell types. The role of erythrocyte membrane sialic acids during aging has been established however the relationship between sialic acid and oxidative stress is not fully understood. ...
Yamagaki Tohru T Suntory Foundation for Life Sciences Bioorganic Research - - 2012
We studied the ionization process of aromatic carboxylic acids, including ones with or without hydroxy groups in matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS), because many natural products, metabolites, and drags contain those structural units. In the actual experimental data, benzoic acid was ionized as only deprotonated molecule [M-H](-). In contrast, ...
Andreychenko Anna - - 2011
At high field (7 T) spectral editing of γ-aminobutyric acid with MEGA-point-resolved spectroscopy is inefficient due to the large chemical shift displacement error. In this article, a new pulse sequence is designed which has minimal chemical shift displacement error to perform an efficient spectral editing of the γ-aminobutyric acid 3.0 ...
Ipema Heather J - - 2011
OBJECTIVE:To evaluate the literature describing topical use of tranexamic acid or aminocaproic acid for prevention of postoperative bleeding after major surgical procedures.DATA SOURCES:Literature was retrieved through MEDLINE (1946-September 2011) and International Pharmaceutical Abstracts (1970-September 2011) using the terms tranexamic acid, aminocaproic acid, antifibrinolytic, topical, and surgical. In addition, reference citations ...
Cawello Willi - - 2011
Two open-label, randomized, multiple-dose clinical studies evaluated the potential for pharmacokinetic interaction between the antiepileptic drugs lacosamide and valproic acid. The influence of lacosamide on valproic acid pharmacokinetics (trial A) and valproic acid on lacosamide pharmacokinetics (trial B) was investigated in 32 healthy male volunteers, 16 in each trial. Volunteers ...
Mignini F - - 2011
α-Lipoic acid is an important micronutrient with several pharmacological as well as antioxidant properties. The present study was aimed to examine the human bioavailability, pharmacokinetics (PK) and tolerability of an innovative oral formulation (ALA600) containing racemic α-lipoic acid 600 mg. After a single 600-mg oral administration in healthy volunteers, blood ...
Yousef Jumana M - - 2012
The use of colistin in the treatment of life-threatening Gram-negative infections is associated with a high rate of nephrotoxicity that is dose limiting. This study aimed to examine the nephroprotective effect of ascorbic acid against colistin-induced nephrotoxicity. Rats were treated intravenously twice daily with saline, colistin (cumulative dose of 36.5 ...
Sharma Sandeep Kumar - - 2011
A series of 6-methyl-4-[1-(2-substituted-phenylamino-acetyl)-1H-indol-3-yl]-2-oxo/thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid ethyl esters (1-16) were synthesized and evaluated in vitro for their antimicrobial and anticancer potential. 6-Methyl-4-{1-[2-(4-nitro-phenylamino)-acetyl]-1H-indol-3-yl}-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid ethyl ester (15, pMIC(ec) = 2.50 μM/mL) was found to be almost equipotent to the standard drug, norfloxacin (pMIC(ec) = 2.61 μM/mL) against Escherichiacoli and emerged as most potent antimicrobial agent (pMIC(am) = 1.84 μM/mL). 4-{1-[2-(2-Chloro-4-nitro-phenylamino)-acetyl]-1H-indol-3-yl}-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid ethyl ...
Sathe Manisha - - 2011
Immunoassay detection of O-pinacolyl methylphosphonic acid (PMPA) employing direct coating of N-2-aminoethyl-O-pinacolyl methylphosphonate (hapten B) on microtiter plates is reported. Coating was achieved by covalently linking hapten B to a glutaraldehyde (GA) polymer network directly bound to the polystyrene (PS) surface of a standard 96-well microtiter plate. 4-(2-(O-Pinacolylmethylphosphoryl amino)ethyl amino)-4-oxobutanoic ...
Gross Madeleine - - 2011
The Alternaria mycotoxin tenuazonic acid was derivatized with succinic anhydride and conjugated to keyhole limpet hemocyanin (KLH) and to horseradish peroxidase (HRP), respectively. The KLH conjugate was used to produce polyclonal antibodies in rabbits. A competitive direct enzyme immunoassay (EIA) for tenuazonic acid was established, which was moderately sensitive for ...
Wang Changhe - - 2011
To separate and determine oleanolic acid and ursolic acid, a rapid and accurate HPLC using γ-CD as the mobile phase additive was developed. The effect of CD nature and concentration, and the acidity of the mobile phase on the chromatographic behavior of two bioactive triterpenes were systematically studied. Two bioactive ...
Zhao Hua - - 2011
Betulinic acid is a natural product possessing abundant and favourable biological activity, including anti-cancer, anti-malarial, anti-inflammatory and anti-HIV properties, while causing minimal toxicity to unaffected cells. The full biological potency of betulinic acid cannot be fully unlocked, however, for a number of reasons, a primary one being its limited solubility ...
Mossop Hannah - - 2011
: To evaluate the influence of lactic acid on immune mediator release from vaginal epithelial cells. : The human vaginal epithelial cell line, VK2/E6E7, was cultured in the presence or absence of physiological concentrations of lactic acid, and in the presence or absence of the viral Toll-like receptor 3 agonist, ...
Sivakumar R - - 2011
Vector control is facing a threat due to emergence of resistance to synthetic insecticides. Compounds that mediate the oviposition of mosquitoes: a possible sustainable tool for the control and monitoring of Culicidae. The present study to evaluate oviposition attractancy of dodecanoic, hexadecanoic and tetradecanoic acid (isolated from conspecific eggs) against ...
Nasiri A H - - 2011
The aim of this study was to investigate the effect of adding n-3 fatty acids (FA) and α-tocopherol (VE) to semen extender on freezing ability and FA composition of bull sperm. Semen was collected from 10 Iranian Holstein bulls and was pooled. In the first experiment, semen was divided into ...
Pszczolkowski Maciej A - - 2011
Codling moth, Cydia pomonella, (L.), is a cosmopolitan pest of apple, potentially causing damage to circa 80% of the fruit. Currently used methods of combating this insect are inadequate or harmful to environment. The use of plant-derived semiochemicals for manipulation with fruit-infesting behavior is one of new avenues for controlling ...
Molina-Hernández Miguel - - 2011
Intra-cerebral administrations of folic acid produce antidepressant-like effects; either alone or combined with several antidepressant drugs. However, the specific limbic structures implied in the antidepressant-like actions of folic acid are un-known. Thus, intra-lateral septal infusions of folic acid (5.0nmol, P<0.05; 10.0nmol, P<0.05) or oral administrations of folic acid (50mg/kg, P<0.05, ...
Sivakumar R - - 2011
To investigate the larvicidal and repellent efficacy of tetradecanoic acid against Aedes aegypti (Ae. aegypti) L. and Culex quinquefasciatus (Cx. quinquefasciatus) Say (Diptera: Culicidae). Larvicidal efficacy of tetradecanoic acid was tested at various concentrations against the early third instar larvae of Ae. aegypti and Cx. quinquefasciatus. The repellent activity was ...
Arruzazabala M L - - 2011
D-004, a lipid extract of Roystonea regia fruits that contains oleic, lauric and myristic acids as major components inhibits alpha1-adrenoreceptors-mediated contractile responses in isolated rat vas deferens and prostate trips; no study has demonstrated a similar effect for oleic, lauric or myristic acids individually. Therefore, the effects of D-004 (250 ...
Gan Xiaojuan - - 2011
A novel fluorescence quenching method for the determination of tetracaine hydrochloride (TA·HCl) concentration with some aromatic amino acids as fluorescence probe has been developed. In pH 6.3 acidic medium, tryptophane (Trp), tyrosine (Tyr) or phenylalanine (Phe) can react with tetracaine hydrochloride to form an ion-association complex by electrostatic attraction, aromatic ...
Rivero-Cruz Blanca E - - 2011
A new anacardic acid, 6-[16'Z-nonadecenyl]-salicylic acid (1), along with seven known compounds, 6-[8'Z-pentadecenyl] salicylic acid (15:1 anacardic acid) (2), 6-nonadecenyl salicylic acid (anacardic acid 19:0) (3), 6-pentadecyl salicylic acid (anacardic acid 15:0) (4), masticadienonic acid (5), 3α-hydroxymasticadienonic acid (6), 3-epi-oleanolic acid (7) and β-sitosterol, were isolated from the bark of ...
Raal Ain - - 2011
The content of total polyphenols, flavonoids and coumarins in the aerial parts of pineapple weed (Chamomilla suaveolens (Pursh) Rydb.), growing wild in Estonia, was determined chromato-spectrophotometrically, and individual polyphenols were quantified using HPLC-DAD-MS/MS. The total content of polyphenols was rather similar in flowers (9.1-11.5%) and in whole aerial parts (8.4-10.9%) ...
Pham Anh Thu - - 2011
From a methanol extract of the leaves of the Malian medicinal tree Terminalia macroptera, cis-polyisoprene (1), chebulic acid trimethyl ester (2), methyl gallate (3), shikimic acid (4), corilagin (5), rutin (6), narcissin (7), chebulagic acid (8) and chebulinic acid (9), were isolated. Cispolyisoprene (1) was the major non-polar constituent. The ...
Anthony J-P - - 2011
Following previous work on the anti-giardial effect of blueberry polyphenols, a range of polyphenol-rich extracts from berries and other fruits was screened for their ability to kill Giardia duodenalis, an intestinal parasite of humans. Polyphenol-rich extracts were prepared from berries using solid-phase extraction and applied to trophozoites of Giardia duodenalis ...
Strom Sean M - - 2011
Wetlands play a major role in the export of methylmercury (MeHg) to a watershed. The large contribution of wetlands to watersheds in northern Wisconsin, coupled with the acidic environment of this area, makes these habitats especially vulnerable to mercury (Hg) accumulation by biota. The purpose of this study was to ...
Sokolsky-Papkov Marina - - 2011
PURPOSE: To reduce formulation viscosity of bupivacaine/poly(DL lactic acid co castor oil) 3:7 without increasing bupivacaine release rates. METHODS: Poly(DL lactic acid) 3:7 was synthesized and bupivacaine formulation prepared by mixing with additives ricinoleic acid or castor oil. In vitro release measurements identified optimum formulation. Anesthetized ICR mice were injected ...
Xie Junbo - - 2012
In this study, the composition of fatty oil from Semen Ziziphi Spinosae and its cardiotonic activity on the heart isolated from a toad were studied. Oil-in-water (O/W) emulsions of fatty oil were prepared by the perfusion method. The fatty oil had a positive inotropic effect on isolated rat hearts at ...
Liobikas Julius - - 2011
Ursolic acid (1), a pentacyclic triterpene acid, is one of the major components of certain traditional medicinal plants and possesses a wide range of biological effects, such as anti-inflammatory, antioxidative, and cytotoxic activities. Furthermore, 1, when present at 1.6-5 ng/mL concentrations in commercial herbal preparations used for patients with cardiac ...
Wang Meng Yue - - 2011
A novel protein with antitumor activity, Hailongin, was purified from the aqueous extract of the whole body of Trachyrhamphus serratus, which is commonly used in traditional Chinese medicine, by bioassay-guided fractionation. Hailongin exhibited strong inhibition of proliferation of the tested human cell lines, such as A549, HeLa, LoVo and CCRF-CEM. ...
Ponomarenko Ludmila P - - 2011
19-Norspongia-13(16),14-diene-3-one (1) was isolated for the first time from a natural source, along with a series of known spongiane diterpenoids (2-11) and sesquiterpene (12) from two unidentified species belonging to the genus Spongia. The effects of 1, 4, 5, 8-12 on biosynthesis of nucleic acids and embryonic development of the ...
Onasanwo Samuel A - - 2011
Anti-ulcer potential and proton pump inhibitory activity of kolaviron (KV) isolated from Garcinia kola Heckel has been evaluated using different ulcer models. Cold-restraint (CRU), aspirin (ASP), alcohol (AL), pyloric ligation (PL) induced gastric ulcer models were used to assess anti-ulcerogenic activity of KV in rats. Effects of KV on gastric ...
Greiner Christine - - 2011
5-Lipoxygenase (5-LO) and microsomal prostaglandin E(2) synthase (mPGES)-1 are key enzymes in the biosynthesis of leukotrienes and prostaglandin (PG)E(2), respectively, and are considered as valuable targets for the treatment of inflammatory diseases. Here, we present the identification of 2-mercaptohexanoic acid derivatives as dual inhibitors of 5-LO and mPGES-1. The lead ...
Fitschen Peter J - - 2011
Abstract English walnuts have been shown to decrease cardiovascular disease risk; however, black walnuts do not appear to have not been studied for their cardioprotective effects. The purpose of this study was to determine the effects of English versus black walnut consumption on blood lipids, body weight, fatty-acid composition of ...
Ni Guo-Hua - - 2011
Epoxyeicosatrienoic acids (EETs) are cytochrome P450 (CYP450) products of arachidonic acid and EETs are endogenous lipid mediators synthesized by the vascular endothelium which perform important biological functions, including vasodilation, anti-inflammation, antimigratory, and cellular signaling regulations. However, EETs are rapidly degraded by soluble epoxide hydrolase (sEH) to the corresponding diols: dihydroxyeicosatrienoic ...
Finelli Ivana - - 2011
A novel partially hydrophobized derivative of hyaluronic acid (HYADD®4), containing a low number of C16 side-chains per polysaccharide backbone, provides injectable hydrogels stabilized by side-chain hydrophobic interactions. The rheological properties of Hymovis®, a physical hydrogel based on the hyaluronic acid derivative HYADD®4, were evaluated using as reference a solution of ...
Parnell J Jacob - - 2011
Shewanellae are microbial models for environmental stress response; however, the sequential expression of mechanisms in response to stress is poorly understood. Here we experimentally determine the response mechanisms of Shewanella amazonensis SB2B during sodium chloride stress using a novel liquid chromatography and accurate mass-time tag mass spectrometry time-course proteomics approach. ...
Kakutani Saki - - 2011
The importance of arachidonic acid (ARA) among the elderly has recently gained increased attention. The effects of ARA supplementation in the elderly are not fully understood, although ARA is considered to be associated with various diseases. We investigate whether ARA supplementation to Japanese elderly subjects affects clinical parameters involved in ...
Karakatsani Marianthi - - 2010
The objective of this study was to characterize the release of Diltiazem HCl (DTM HCl) from hydroxypropyl methylcellulose gels containing the following permeation enhancers at a 0.5% (w/w): sodium lauryl sulfate, dimethyl sulfoxide (DMSO), polysorbate 80, propylene glycol, N-methylpyrrolidone (NMP), fatty acids (oleic acid, caprylic acid, and myristic acid), and ...
Cha Minseok - - 2011
A mesophilic bacterium capable of utilizing acrylamide was isolated, AUM-01, from soil collected from leaf litter at Picnic Point on the UW-Madison campus. In minimal medium with acrylamide as the sole carbon and nitrogen source, a batch culture of AUM-01 completely converted 28.0 mM acrylamide to acrylic acid in 8 h and ...
Sen Murat - - 2011
In this study, the effects of the molecular weight and ratio of guluronic acid (G) to mannuronic acid (M), G/M, of some sodium alginate (NaAlg) fractions on their antioxidative properties were investigated. Low-molecular-weight-fractions with various G/M were prepared by gamma radiation-induced degradation of NaAlg. Change in their molecular weight was ...
Lagadec Cecile - - 2011
We report a synthetically simple approach to effective and tunable low molecular weight gelators based on amine-initiated oligomerisation of an amino acid N-carboxyanhydride.
Bevilacqua Antonio - - 2010
This study reports on the investigation on the effects of the conditions used throughout the step of biomass production on the survival of Lactobacillus plantarum loaded into alginate gels. L. plantarum was grown under different conditions (MRS or a laboratory medium-LB(2)-at acidic or alkaline pHs, with NaCl, phenols, vitamins or ...
van der Veeken Pascal L R - - 2010
Gel layer based sensors are increasingly employed for dynamic trace metal speciation analysis in aquatic and soil media. In DGT (Diffusive Gradient in Thin film), polyacrylamide hydrogels are commonly used for the diffusive gel layer. While some effects of humic and fulvic acids on the DGT detection of metal species ...
De Pablos Luis Miguel - - 2010
We propose maslinic acid (2-alpha, 3-beta-dihydroxiolean-12-en-28-oic acid), found in the leaves and fruit of the olive tree (Olea europaea L.), as a new natural coccidiostatic product against Eimeria tenella. Its action in infected animals has been compared with animals treated with sodium salinomycin. The lesion index (LS), the oocyst index ...
Hubbell Christopher A - - 2010
Two types of pure cellulose, Avicel PH-101 and Whatman filter paper, were treated with an acid-chlorite delignification procedure in the presence of varying amounts of incorporated lignin, and the molecular weight distributions and degrees of polymerization (DP) of derivatized cellulose were determined by gel permeation chromatography (GPC). Avicel samples with ...
Kim Yoon Kyung - - 2010
One of the fundamental challenges in studying biomacromolecules (e.g. nucleic acids and proteins) and their complexes in a biological system is isolating them in their structurally and functionally intact forms. Electrophoresis offers convenient and efficient separation and analysis of biomacromolecules but recovery of separated biomacromolecules is a significant challenge. In ...
Suksrichavalit Thummaruk - - 2010
In this paper, we present a new modular approach to immobilize boronic acid ligands that can offer effective separation of glycoproteins. A new "clickable" boronic acid ligand was synthesized by introducing a terminal acetylene group into commercially available 3-aminophenyl boronic acid. The clickable ligand, 3-(prop-2-ynyloxycarbonylamino)phenylboronic acid (2) could be easily ...
Tabarestani H Shahiri - - 2010
Physico-chemical properties of gelatin extracted from rainbow trout (Onchorhynchus mykiss) skin were optimized using response surface methodology (RSM). Central rotatable composite design was applied to study the combined effects of NaOH concentration (0.01-0.21 N), acetic acid concentration (0.01-0.21 N) and pre-treatment time (1-3h) on yield, molecular weight distribution, gel strength, ...
Furuhashi Takeshi - - 2010
Acidic macromolecules, as a nucleation factor for mollusc shell formation, are a major focus of research. It remains unclear, however, whether acidic macromolecules are present only in calcified shell organic matrices, and which acidic macromolecules are crucial for the nucleation process by binding to chitin as structural components. To clarify ...
Sol?s de los Santos Fausto - - 2010
Campylobacter is a leading cause of foodborne illness in the United States, and epidemiological evidence indicates poultry products to be a significant source of human Campylobacter infections. Caprylic acid, an eight-carbon medium-chain fatty acid, reduces Campylobacter colonization in chickens. How caprylic acid reduces Campylobacter carriage may be related to changes ...
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