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Oliver Michael F MF *University of Edinburgh, Scotland, - - 2015
Plasma free fatty acids (non-esterified fatty acids) increase in the first hour of the onset of acute myocardial ischaemia. This results from catecholamine stimulation of adipose tissue lipolysis. It can lead to a metabolic crisis in the injured myocardium with the development of ventricular arrhythmias and increased early mortality. Preconditioning, ...
Zhu Hong-Hu HH Peking University People's Hospital, Beijing, China - - 2014
A pilot study reveals that an oral preparation of arsenic appears to be as effective as intravenous arsenic trioxide in inducing remissions in acute promyelocytic leukemia. The curative regimen may be administered on an outpatient basis in some cases.
Bissell D Montgomery DM Division of Gastroenterology, Department of Medicine, University of California, San Francisco. Electronic address: - - 2014
Attacks of neuropathic pain, usually abdominal, are characteristic of the acute porphyrias and are accompanied by overproduction of heme-precursor molecules, specifically delta-aminolevulinic acid and porphobilinogen. The basis for the acute symptoms in these diseases has been speculative. We review genetic acute porphyria, hereditary tyrosinemia, and an acquired condition, lead poisoning. ...
Peng Yue - - 2014
The fresh and arsenic poisoned V2O5-WO3/TiO2 catalysts are investigated by experiments and DFT calculations for the SCR activity and deactivation mechanism. Poisoned catalyst (1.40 % of arsenic) presents lower NO conversion and more N2O formation than fresh. Stream (5 %) could further decrease the activity of poisoned catalyst above 350 ...
Inamori Masahiko - - 2014
The natural immunomodulator lactoferrin is known to possess anti-inflammatory effects. However, there have been no studies examining the mode of action of lactoferrin in protecting the esophageal mucosa against damage. We investigated the effect of lactoferrin on gastric acid secretion and in protecting against acute acid reflux-induced esophagitis in rats. ...
Holland Aleicia A Central Queensland University, Centre for Environmental Management, Rockhampton, QLD 4702, Australia. Electronic address: - - 2014
Acid mine drainage (AMD) is a global problem leading to the acidification of freshwaters, as well as contamination by heavy metals. The ability of humic substances (HS) such as humic acid (HA) to decrease toxicity of heavy metals is widely known, whereas limited studies have examined the ability of HS ...
Peramuna Anantha A Department of Biology, California State University Northridge, 18111 Nordhoff St., Northridge, CA, 91330-8303, - - 2014
Inclusions of neutral lipids termed lipid droplets (LDs) located throughout the cell were identified in the cyanobacterium Nostoc punctiforme by staining with lipophylic fluorescent dyes. LDs increased in number upon entry into stationary phase and addition of exogenous fructose indicating a role for carbon storage, whereas high-light stress did not ...
Lu Chi-Cheng CC Deaprtment of Food Science and Biotechnology, National Chung Hsing University, Taichung, 40227, - - 2014
Ursolic acid, a natural pentacyclic triterpenic acid, possesses anticancer potential and diverse biological effects, but its correlation with glioblastoma multiforme cells and different modes of cell death is unclear. We studied the cellular actions of human GBM DBTRG-05MG cells after ursolic acid treatment and explored cell-selective killing effect of necrotic ...
Li Fei F Department of Chemistry and Biochemistry, University of Delaware, Newark, DE 19716, - - 2014
Selenenic acids are highly reactive intermediates of selenoproteins' enzymatic reactions. Knowledge of how the protein environment protects and stabilizes them is fundamental not only to descriptions of selenoproteins' reactivity but also potentially for proteomics and therapeutics. However, selenenic acids are considered particularly short-lived and are not yet identified in wild-type ...
Liu Li-Ying LY State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of - - 2014
Five new lanostane triterpenoids, ganoderic acid XL1 (1), ganoderic acid XL2 (2), 20-hydroxy-ganoderic acid AM1 (3), ganoderenic acid AM1 (4) and ganoderesin C (5), together with five known triterpenoids (6-10) were isolated from the fruiting bodies of Ganoderma theaecolum. Chemical structures were elucidated on the basis of spectroscopic evidence, including ...
Branco Anete A Head and Neck Surgery Department, Univ Estadual Paulista, Botucatu Medical School, Ophthalmology, Otorhinolaryngology, São Paulo, - - 2014
To analyze the hyaluronic acid behavior in the lamina propria of the larynx with advancing age. Prospective study. UNESP-Univ Estadual Paulista, Botucatu Medical School, Brazil. Thirty vocal folds were obtained at necropsy from 10 adult males (30-50 years old) and 20 geriatric males (10: 60-75 years old; 10: over 76 ...
Kardar M N MN Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow G4 0RE, Scotland, - - 2014
Chemical investigation of a sample of propolis originating from North-Western Cameroon led to the isolation of thirteen alk(en)ylphenols (1-13) (inseparable mixture) along with α-amyrin (14), β-amyrin (15), lupeol (16), cycloartenol (17), mangiferonic acid (18), ambonic acid (19), mangiferolic acid (20), ambolic acid (21), isomangiferolic acid (22) and nine alk(en)ylresorcinols (23-31) ...
Hardwicke Mary Ann MA 1] Oncology Research and Development, GlaxoSmithKline, Collegeville, Pennsylvania, USA. - - 2014
Human fatty acid synthase (hFAS) is a complex, multifunctional enzyme that is solely responsible for the de novo synthesis of long chain fatty acids. hFAS is highly expressed in a number of cancers, with low expression observed in most normal tissues. Although normal tissues tend to obtain fatty acids from ...
Yamasaki Masao M a Faculty of Agriculture, Department of Biochemistry and Applied Biosciences , University of Miyazaki , Miyazaki , - - 2014
Here, we show that cell surface β1-integrin expression, cell adhesion to fibronectin, migration, and invasion were all significantly inhibited by α-lipoic acid. These effects were not observed when cells were treated with dihydrolipoic acid or caprylic acid. These data reveal that the 1,2-dithiolane structure plays an important role in the ...
Qiao Aimin A School of Life Science and Bio-pharmaceutical, Guangdong Pharmaceutical University, Guangzhou 510006, - - 2014
Sour jujube is a common fruit and traditional medicine in China. Bioactivity-guided fractionation of sour jujube was used to determine the chemical identity of potent antiproliferative and antioxidant constituents. Four novel ursane-type triterpenoids, together with 8 known were isolated and identified. The new triterpenoids were elucidated to be 2α,3β,13β,23-tetrahydroxy-urs-11-en-28-oic acid ...
Liao Lihua L Key Laboratory for Asymmetric Synthesis and Chiral Technology of Sichuan Province, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu, 610041 (China); University of Chinese Academy of Sciences, Beijing, 100049 - - 2014
Highly enantioselective [3+2] coupling of 3-substituted indoles with quinone monoimines promoted by a chiral phosphoric acid has been reported. A large variety of benzofuroindolines were prepared in moderate to good yields (up to 98 %) with generally excellent enantioselectivities (up to 99 % ee).
Heunis Tiaan T Department of Microbiology, Stellenbosch University , Private Bag X1, 7602 Matieland, South - - 2014
Acid tolerance is considered an important characteristic of probiotic bacteria. Lactobacillus plantarum 423 tolerates acidic pH and is the ideal candidate in which to study molecular mechanisms that acid-tolerant lactic acid bacteria employ to survive such conditions. In this study we recorded changes in the protein profile of L. plantarum ...
Wu Chongde C Key Laboratory of Leather Chemistry and Engineering, Ministry of Education, College of Light Industry, Textile & Food Engineering, Sichuan University, Chengdu, 610065, China, - - 2014
The aim of this study was to investigate the acid tolerance response (ATR) in Lactobacillus casei by a combined physiological and proteomic analysis. To optimize the ATR induction, cells were acid adapted for 1 h at different pHs, and then acid challenged at pH 3.5. The result showed that acid adaptation ...
Hossain Gazi Sakir GS School of Food Science and Technology, Jiangnan University, Wuxi 214122, China; Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, Jiangnan University, Wuxi 214122, - - 2014
We previously developed a novel one-step biotransformation process for the production of α-ketoglutarate (α-KG) from l-glutamic acid by a Bacillus subtilis whole-cell biocatalyst expressing an l-amino acid deaminase (pm1) of Proteus mirabilis. However, the biotransformation efficiency of this process was low owing to low substrate specificity and high α-KG degradation. ...
Takahashi Haruya H a Laboratory of Molecular Functions of Food, Division of Food Science and Biotechnology , Graduate School of Agriculture, Kyoto University , Uji , - - 2014
We previously reported that the two peroxisome proliferator-activated receptor-α agonists, 9- and 13-oxo-octadecadienoic acids (oxo-ODAs), were found in the tomato fruit. However, their localization remains unknown. Herein, we showed that oxo-ODAs localize primarily in the fruit peel and their amount increases after the homogenization of the tomato fruit.
Casañas-Sánchez Verónica V Department of Genetics and University Institute of Tropical Diseases and Public Health, University of La Laguna, Tenerife, - - 2014
Docosahexaenoic acid (DHA, 22:6n-3) is a major constituent of nerve cell membrane phospholipids. Besides a role in membrane architecture, DHA is a pleiotropic molecule involved in multiple facets of neuronal biology and also in neuroprotection. We show here that supplementation with DHA (but not arachidonic acid) to mouse hippocampal HT22 ...
Kotajima Tomonori T Graduate School of Life and Environmental Sciences, University of Tsukuba, Tennodai 1-1-1, Tsukuba, Ibaraki 305-8572, Japan; CREST, JST, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8572, - - 2014
The coccolithophorid Emiliania huxleyi is a bloom-forming marine phytoplankton thought to play a key role as a biological pump that transfers carbon from the surface to the bottom of the ocean, thus contributing to the global carbon cycle. This alga is also known to accumulate a variety of polyunsaturated fatty ...
Camera Emanuela E Laboratory of Cutaneous Physiopathology and Integrated Center of Metabolomics Research, San Gallicano Dermatologic Institute, IRCCS, Rome, - - 2014
Lipid droplets (LD) are dynamic organelles that manage cellular lipid synthesis, storage, and retrieval. Although LD-associated proteins, including the perilipin family (PLIN1-PLIN5), are essential for these functions, they have been poorly characterized in sebocytes. Here, we employed siRNAs to downregulate PLIN3 in SZ95 sebaceous gland cells and evaluated the consequences ...
Sonawane Poonam P Cancer Center, Texas Tech University Health Sciences Center, Lubbock, TX; Pharmacology and Neuroscience, Texas Tech University Health Sciences Center, Lubbock, - - 2014
Isotretinoin (13-cis-retinoic acid; 13-cRA) is a differentiation inducer used to treat minimal residual disease after myeloablative therapy for high-risk neuroblastoma. However, more than 40% of children develop recurrent disease during or after 13-cRA treatment. The plasma concentrations of 13-cRA in earlier studies were considered subtherapeutic while 4-oxo-13-cis-RA (4-oxo-13-cRA), a metabolite ...
Büll Christian C Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, PO Box 9101, 6500 HB Nijmegen, The - - 2014
Sialic acids represent a family of sugar molecules derived from neuraminic acid that frequently terminate glycan chains and contribute to many biological processes. Already five decades ago, aberrantly high expression of sialic acids has been proposed to protect cancer cells from recognition and eradication by the immune system. Today, increased ...
Su Yu-Chih YC Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, Kaohsiung, 80708, Taiwan. - - 2014
The regioselective post-synthetic modifications of nucleic acids are essential to studies of these molecules for science and applications. Here we report a facile universal approach by harnessing versatile phosphoramidation reactions to regioselectively incorporate alkynyl/azido groups into post-synthetic nucleic acids primed with phosphate at the 5' termini. With and without the ...
Kitamura Nobuto - - 2014
A double-network (DN) gel, which was composed of poly-(2-Acrylamido-2-methylpropanesulfonic acid) and poly-(N,N'-dimethyl acrylamide) (PAMPS/PDMAAm), has the potential to induce chondrogenesis both in vitro and in vivo. The present study investigated whether DN gel induced chondrogenic differentiation of ATDC5 cells in a maintenance medium without insulin, and whether supplementation of hyaluronic ...
Corino Carlo C Università degli Studi di Milano, Department of Health, Animal Science and Food Safety, Via Celoria 10, 20133 Milan, - - 2014
Nutritional quality of pork is a significant factor for consumers' health. Feeding n-3 PUFA to pigs, using linseed, improves pork nutritional quality. A meta-analysis involving 1006 pigs reported in 24 publications was carried out to assess the effects of dietary linseed on alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), docosapentaenoic acid ...
Snyder Adrienne L AL Department of Chemistry, Carolina Center for Genome Sciences, The University of North Carolina at Chapel Hill, 125 South Road, Chapel Hill, NC 27599 - - 2014
SORTing through the proteome: A versatile method has been developed for the incorporation of a novel 1,3-disubstituted cyclopropene amino acid into the proteome in response to a variety of sense codons and subsequent labeling. Incorporation can be confined to certain tissues by the selective expression of an orthogonal tRNA synthetase ...
Wakamiya Tomihiro T Department of Neuropathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, - - 2014
Fatty acid synthase (FASN) and carnitine palmitoyltransferase 1C (CPT1C), a brain-specific isoform of the CPT1 family, are upregulated in certain types of cancers, including gliomas. Acetyl-CoA carboxylase (ACC) catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis, and its phosphorylated form inhibits lipid synthesis. We ...
Louesdon Séverine S UMR 782 Génie et Microbiologie des Procédés Alimentaires, AgroParisTech - INRA, Thiverval-Grignon, 78850, France; Laboratoire Procédés Bactéries, Lallemand SAS, Blagnac Cedex, 31702, - - 2014
Determinations of membrane fatty acid composition and fluidity were used together with acidification activity and viability measurements to characterize the physiological state after freezing of Lactobacillus buchneri R1102 and Bifidobacterium longum R0175 cells harvested in the exponential and stationary growth phases. For both strains, lower membrane fluidity was achieved in cells harvested ...
Pelà M - - 2014
The synthesis of non natural amino acid 2-amino-3,3,4-trimethyl-pentanoic acid (Ipv) ready for solid phase peptide synthesis has been developed. Copper (I) chloride Michael addition, followed by a Curtius rearrangement are the key steps for the lpv synthesis. The racemic valine/leucine chimeric amino acid was then successfully inserted in position 5 ...
Schenkel Laila Cigana LC Department of Human Health and Nutritional Sciences, University of Guelph, Animal Science and Nutritional Bldg., Rm. 309, Guelph, ON, N1G 2W1, Canada, - - 2014
Choline is an essential nutrient required for the biosynthesis of membrane lipid phosphatidylcholine (PtdCho). Here we elucidate the mechanism of how palmitic acid (PAM) and oleic acid (OLA) regulate choline transporter-like protein 1 (CTL1/SLC44A1) function. We evaluated the mechanism of extracellular and intracellular transport of choline, and their contribution to ...
Neethling J J Department of Food Science, Stellenbosch University, Private Bag X1, Matieland 7602, South Africa; Department of Animal Sciences, Stellenbosch University, Private Bag X1, Matieland, Stellenbosch, 7602, South - - 2014
This study quantified the impact of season on fatty acid profiles of male and female blesbok muscles (longissimus thoracis et lumborum, biceps femoris, semimembranosus, semitendinosus, infraspinatus, and supraspinatus). Eight mature blesbok were harvested per season (winter and spring). Gender and muscle type influenced (p<0.05) the fatty acid profiles of blesbok ...
Jo Ye-Seul - - 2014
Candida boidinii was selected as a γ-dodecelactone producer because of the highest production of γ-dodecelactone from 10-hydroxy-12(Z)-octadecenoic acid among the 11 yeast strains tested. Under the reaction conditions of pH 5.5 and 25 °C with 5 g/L 10-hydroxy-12(Z)-octadecenoic acid and 30 g/L cells, whole C. boidinii cells produced 2.1 g/L ...
Mohd Yusoff Abd Rashid Bin - - 2014
We demonstrated the inverted solution processed tandem polymer solar cells, in which transparent pH-neutral poly(3,4-ethylenedioxylenethiophene)-polystylene sulfonic acid (PEDOT:PSS) and lithium zinc oxide layers were used as a recombination layer. We have used poly(di(2-ethylhexyloxy)benzo[1,2-b:4,5-b']dithiophene-co-octylthieno[3,4-c]pyrrole-4,6-dione):[6,6]-phenyl-C61 butyric acid methyl ester (PBDTTPD:PC61BM) and poly[(4,4'-bis(2-ethylhexyl)dithieno[3,2-b:2',3'-d] silole)-2,6-diyl-alt-(2,1,3-benzothiadiazole)-4,7-diyl]:[6,6]-phenyl-C70 butyric acid methyl ester (PSBTBT:PC70BM) as the active layers ...
Gallardo Maria A MA Escuela de Graduados, Facultad de Ciencias Veterinarias, Universidad Austral de Chile, Valdivia, - - 2014
There is no information about the effect of different pasture types on tissue fatty acid profiles of a native rustic lamb breed of the Chiloe Archipelago, the Chilota. Eight Chilota lambs were grazed on a 'Calafatal' pasture (CP), a typical secondary succession of Chiloé Archipelago (Chile) and eight Chilota lambs ...
Lam P-L PL Department of Applied Biology and Chemical Technology, State Key Laboratory of Chirosciences , The Hong Kong Polytechnic University, Hong Kong , P.R. China - - 2014
Abstract l-ascorbic acid is an abundant water-soluble nutrient found in vegetables and fruits. It enhances the cell proliferation, which is helpful in wound healing process. However, it is relatively unstable and easily degraded under external environments including acidity, alkalinity, evaporation, heat, oxidization, light or moisture. Its storage remains challenged. This ...
Hu Jun Jacob JJ Morningside Laboratory for Chemical Biology, Department of Chemistry, The University of Hong Kong , Pokfulam Road, Hong Kong, P. R. - - 2014
A HKOCl-2 series of new fluorescent probes for hypochlorous acid (HOCl) detection in live cells is reported. The probes exhibit excellent selectivity, sensitivity, and chemostability toward HOCl. In particular, HKOCl-2b rapidly and selectively detects endogenous HOCl in both human and mouse macrophages. These probes could therefore serve as promising discovery ...
Szabó Milán M Plant Functional Biology and Climate Change Cluster, University of Technology Sydney, Broadway, NSW 2007, Australia. Electronic address: - - 2014
Multi-wavelength chlorophyll fluorescence analysis was utilised to examine the photosynthetic efficiency of the biofuel-producing alga Nannochloropsis oculata, grown under two light regimes; low (LL) and high (HL) irradiance levels. Wavelength dependency was evident in the functional absorption cross-section of Photosystem II (σII(λ)), absolute electron transfer rates (ETR(II)), and non-photochemical quenching ...
Dulermo Rémi R INRA, UMR1319 Micalis, Jouy-en-Josas, F-78352, France; AgroParisTech, UMR Micalis, F-78350, Jouy-en-Josas, - - 2014
In order to live, cells need to import different molecules, such as sugars, amino acids, or lipids, using transporters. In Saccharomyces cerevisiae, the ScFAT1 gene encodes the long-chain fatty acid transporter; however, the transport of fatty acids in the oleaginous yeast Yarrowia lipolytica has not yet been studied. In contrast to what ...
Güney Gamze G Faculty of Medicine, Department of Medical Biology, Sakarya University, Sakarya, Turkey. Electronic address: - - 2014
In this paper, ascorbic acid (Vitamin C, AA) known as an antioxidant was successfully incorporated in solid lipid nanoparticles (SLNs) by hot homogenization and efficient delivery of AA to cancer cells. The obtained SLN formulations were characterized by Nano Zetasizer ZS and HPLC with the particle size being less than ...
Stiebing Clara C Leibniz Institute of Photonic Technology (IPHT), Albert-Einstein-Straße 9, 07745, Jena, - - 2014
Macrophages are phagocytic cells which are involved in the non-specific immune defense. Lipid uptake and storage behavior of macrophages also play a key role in the development of atherosclerotic lesions within walls of blood vessels. The allocation of exogenous lipids such as fatty acids in the blood stream dictates the ...
Kawaguchi Minako M Department of Metabolism & - - 2014
Context: Intramyocellular lipid (IMCL) accumulation is observed in both insulin-resistant subjects and insulin-sensitive endurance athletes (athlete's paradox). We hypothesized that the expression pattern of fatty acid transporters may influence oxidative capacity and determine the association between IMCL and insulin resistance. Objective: To investigate the muscle expression of fatty acid transporters ...
Liang Yanna Y Department of Civil & Environmental Engineering, Southern Illinois University Carbondale, 1230 Lincoln Dr., Carbondale, IL, 62901, USA, - - 2014
Corn fiber and sweet sorghum bagasse (SSB) are both pre-processed lignocellulosic materials that can be used to produce liquid biofuels. Pretreatment using dilute sulfuric acid at a severity factor of 1.06 and 1.02 released 83.2 and 86.5 % of theoretically available sugars out of corn fiber and SSB, respectively. The resulting ...
Li Meng M Department of Chemistry, University of Bath, Claverton Down, UK. t.d.james@bath.ac.uk - - 2014
Copper ions are essential for many biological processes. However, high concentrations of copper can be detrimental to the cell or organism. A novel naphthalimide derivative bearing a monoboronic acid group (BNP) was investigated as a Cu(2+) selective fluorescent sensor in living cells. This derivative is one of the rare examples ...
Usami Atsushi A Department of Applied Chemistry, Faculty of Science and Engineering, Kinki - - 2014
In this study, the characteristic odorants of the volatile oils from Pleurotus species (P. eryngii var. tuoliensis and P. cystidiosus) were extracted by hydrodistillation and analyzed by gas chromatography-mass spectrometry (GC-MS), gas chromatography-olfactometry (GC-O), and aroma extract dilution analysis (AEDA). A total of 52 and 54 components (P. eryngii var. ...
Ilavenil Soundarrajan - - 2014
Back ground: Intramuscular fat deposition in the meat animal is relatively new strategy for developing the meat quality. Fat deposition is largely depending on the adipocyte proliferation and differentiation. Therefore, we investigated the effect of chloroform extract of L. multiflorum [CELM] on cell proliferation, lipid accumulation and adipocyte differentiation in ...
Murray Andrew J AJ Department of Physiology, Development & Neuroscience, University of Cambridge, Cambridge, - - 2014
At extreme altitude (>5,000 - 5,500 m), sustained hypoxia threatens human function and survival, and is associated with marked involuntary weight loss (cachexia). This seems to be a coordinated response: appetite and protein synthesis are suppressed, and muscle catabolism promoted. We hypothesise that, rather than simply being pathophysiological dysregulation, this cachexia ...
Mohandas Rajesh R Renal Section, North Florida/South Georgia Veterans Health System, Gainesville, Florida; Division of Nephrology, Hypertension & Transplantation, University of Florida, Gainesville, Florida, United States of America. Electronic address: - - 2014
Uric acid affects endothelial and adipose cell function and has been linked to diseases such as hypertension, metabolic syndrome, and cardiovascular disease. Interestingly uric acid has been shown to increase endothelial progenitor cell (EPC) mobilization, a potential mechanism to repair endothelial injury. Since EPC mobilization is dependent on activity of ...
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