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Husar Richard - - 2014
The reducing conditions in a nuclear waste repository render neptunium tetravalent. Thus, Np is often assumed to be immobile in the subsurface. However, tetravalent actinides can also become mobile if they occur as colloids. We show that Np(IV) is able to form silica-rich colloids in solutions containing silicic acid at ...
Wang Yang Y State Key Laboratory of Coordination Chemistry, Center for Multimolecular Organic Chemistry, School of Chemistry and Chemical Engineering, Nanjing University , Nanjing 210093, - - 2014
An effective Pd-catalyzed hydrocarboxylation of olefins with phenyl formate and formic acid is described. A variety of carboxylic acids are obtained in good yields with high regioselectivities under operationally simple conditions without the use of toxic CO gas.
Sattler Johann H JH Institut für Chemie, Organische und Bioorganische Chemie, University of Graz, Heinrichstrasse 28, 8010 Graz (Austria); Austrian Centre of Industrial Biotechnology (ACIB), Petersgasse 14, 8010 Graz - - 2014
The combination of two cofactor self-sufficient biocatalytic cascade modules allowed the successful transformation of cyclohexanol into the nylon-6 monomer 6-aminohexanoic acid at the expense of only oxygen and ammonia. A hitherto unprecedented carboxylic acid capping strategy was introduced to minimize the formation of the dead-end intermediate 6-hydroxyhexanoic acid. For this ...
Kaiser Ralf I RI Department of Chemistry, W. M. Keck Research Laboratory in Astrochemistry, University of Hawaii at Manoa, 2545 McCarthy Mall, Honolulu, HI 96822 (USA). - - 2014
Contemporary mechanisms for the spontaneous formation of glycerol have not been able to explain its existence on early Earth. The exogenous origin and delivery of organic molecules to early Earth presents an alternative route to their terrestrial in situ formation since biorelevant molecules like amino acids, carboxylic acids, and alkylphosphonic ...
Shi Zhi-Hao ZH Nanjing University of Chinese Medicine, National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine , 138 Xianlin Road, Nanjing 210023, Jiangsu , PR China +86 25 85811916 ; +86 25 85811916 ; linianguang@njutcm.edu.cn , - - 2014
Thrombotic disorders can lead to deep vein thrombosis, myocardial infarction and stroke. Thrombin plays a vital role in cascade reaction of blood coagulation, inhibition of the activity of thrombin can block the formation of thrombus and direct thrombin inhibitor has a prospect to overcome the limitations in application of the ...
Wang Lin L Department of Chemistry, Zhejiang University, Hangzhou, 310027, Zhejiang, - - 2014
The noncovalent complex interactions between cyclofructans, a new class of cyclic oligosaccharide hosts, and various amino acids have been characterized by means of electrospray ionization mass spectrometry and nuclear magnetic resonance. The 1 : 1 stoichiometry of cyclofructans and amino acid complexes was confirmed by their mass-to-charge ratio in positive mode. Cyclofructans ...
Guichardant Michel M Université de Lyon, UMR 1060 Inserm (CarMeN), UMR 1397 INRA, INSA-Lyon, IMBL, Villeurbanne, France. Electronic address: - - 2014
Numerous epidemiological studies and clinical trials have reported the health benefits of omega-3 polyunsaturated fatty acids (PUFA), including a lower risk of coronary heart diseases. This review mainly focuses on the effects of alpha-linolenic (ALA), eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids on some risk factors associated with atherothrombosis, including platelet ...
Unni Sreekuttan M SM Physical and Materials Chemistry Division, CSIR-National Chemical Laboratory, Pune, Maharashtra-411008, India. - - 2014
Layer-separated 3D nitrogen doped graphene (NG) with an accessible interstitial surface and modulated activity characteristics for oxygen reduction in acidic medium could be prepared by wrapping NG sheets on in situ generated carbon nitride (CNx) tetrapods.
Gheerardijn Vicky V Department of Organic Chemistry, Gent University, Krijgslaan 281, 9000 Gent - - 2014
SCNAC, the XVIth Symposium on Chemistry of Nucleic Acid Components, was held in Český Krumlov (Czech Republic) in June. This year's symposium, which covered the chemistry, biochemistry, biophysics and chemical biology of nucleobases, nucleosides, nucleotides and nucleic acids attracted more than 150 participants from 21 countries to its lectures, oral ...
Alkorta Ibon I Instituto de Química Médica, CSIC, Juan de la Cierva, 3, 28006 Madrid (Spain), Fax: (+34) 91-5644853. - - 2014
Several convergent techniques were used to characterize 1,1'-bi-2-naphthol (BINOL) and some of its properties. Its acidity in the gas-phase, from neutral species to monoanion, was measured by mass spectrometry. The conformation and structure of BINOL in the gas phase was determined by microwave rotational spectroscopy. NMR experiments in fluorosulfonic acid ...
Zhou Min M Key Laboratory of Tobacco Chemistry of Yunnan Province, China Tobacco Yunnan Industrial Co., Ltd. , Kunming 650231, People's Republic of - - 2014
Aspergillines A-E (1-5) are highly oxygenated cyclopiazonic acid (CPA)-derived alkaloids bearing a rigid and sterically congested hexacyclic indole-tetrahydrofuran-tetramate scaffold, isolated from the endophytic fungus Aspergillus vesicolor. Apergillines A-C represent a new subclass of CPA-derived alkaloids, and aspergillines B and E possess a butanoic acid methyl ester moiety. The structures, including ...
Ren Ang A Key Laboratory of Microbiological Engineering of Agricultural Environment, Ministry of Agriculture, Microbiology Department, College of Life Sciences, Nanjing Agricultural University, Nanjing, 210095, Jiangsu, People's Republic of - - 2014
Acetic acid at 5-8 mM increased ganoderic acid (GA) accumulation in Ganoderma lucidum. After optimization by the response surface methodology, the GA content reached 5.5/100 mg dry weight, an increase of 105 % compared with the control. The intermediate metabolites of GA biosynthesis, lanosterol and squalene also increased to 47 and 15.8 μg/g dry ...
Santhanaraj Daniel D School of Chemical, Biological and Materials Engineering, University of Oklahoma, 100 E. Boyd Street, Room T301 Norman, OK 73019 - - 2014
Fast pyrolysis of biomass to produce a bio-oil followed by catalytic upgrading is a widely studied approach for the potential production of fuels from biomass. Because of the complexity of the bio-oil, most upgrading strategies focus on removing oxygen from the entire mixture to produce fuels. Here we report a ...
Assemany Paula Peixoto - - 2014
The objective of this paper is to compare the lipid content and composition ofbiomass produced by a consortium of microalgae and bacteria, cultivated under different solar radiation intensities and tropical conditions in pilot-scale high-rate ponds (HRPs) using domestic sewage as culture medium. The treatment system consisted of an upflow anaerobic ...
Ge Xiang-Yang - - 2014
This study describes a novel strategy to regulate metabolic flux for lactic acid production in Lactobacillus casei. The ldhL gene encoding L-lactate dehydrogenase (L-LDH) was overexpressed in the L. casei, and a two-stage oxygen supply strategy (TOS) that maintained medium oxygen supply level (MOS) during early fermentation phase, and low ...
Garzon Andres - - 2014
The mechanism and kinetics of reactions between coumaric acids and a series of reactive oxygen species (•OX) was studied through the Density Functional Theory (DFT). H-atom abstraction from -OH and -COOH groups and addition to the non-aromatic double bond were the most representative reaction pathways chosen for which free energy ...
Choe Jung-Yoon JY Devision of Rheumatology, Department of Internal Medicine, Arthritis & Autoimmunity Research Center, Catholic University of Daegu School of Medicine, Daegu, Republic of - - 2014
The association between serum uric acid concentrations and inflammation in patients with rheumatoid arthritis (RA) has been still controversial. A total of 172 patients with RA who added leflunomide to methotrexate (MTX) in their treatment regimens were enrolled in this study. Twenty-seven RA patients taking MTX without leflunomide were also ...
Adams Sarah E SE School of Chemistry, Main Building, Cardiff University, Park Place, Cardiff, CF10 3AT, - - 2014
Excessive activity of neutrophils has been linked to many pathological conditions, including rheumatoid arthritis, cancer and Alzheimer's disease. Calpain-I is a Ca(2+)-dependent protease that plays a key role in the extravasation of neutrophils from the blood stream prior to causing damage within affected tissues. Inhibition of calpain-I with small molecule ...
Shin Jung Min JM School of Chemical Engineering, College of Engineering, Sungkyunkwan University, Suwon 440-746, Republic of Korea. - - 2014
In an effort to improve the therapeutic efficacy of methotrexate (MTX), we prepared the hyaluronic acid-MTX conjugate for targeted therapy of rheumatoid arthritis (RA). Owing to the pH-sensitive nature of the conjugate, MTX was rapidly released under the mildly acidic conditions, similar to the environment of inflamed synovial tissue in ...
Meek Inger L - - 2014
Gout and hyperuricaemia may be associated with increased cardiovascular risk, but analyses in different populations show conflicting results. This study investigates the impact of serum uric acid, inflammation and traditional CV risk parameters on CV event risk in patients with gouty arthritis and patients with non-gouty rheumatic disease. cross-sectional and ...
Soni Ashwani A Department of Orthopaedics, GGS Medical College and Hospital, Faridkot, - - 2014
Tranexamic acid is an antifibrinolytic drug used widely to prevent bleeding. Its use in reducing bleeding during total knee arthroplasty surgery is well proven but there is no final consensus regarding the regimen. The purpose of our study was to compare the effectiveness of intravenous and intra-articular regimen of tranexamic ...
Zhang Huawei H School of Pharmacy, Second Military Medical University, Shanghai 200433, P.R. - - 2014
Huang-Lian-Jie-Du-Tang (HLJDT oren-gedoku-to in Japanese), a classical traditional Chinese medicine (TCM) formula, is well known for the treatment of inflammatory-related diseases such as gastritis, dermatitis, and ulcerative colitis. Our previous studies have indicated that HLJDT has therapeutic potential in rheumatoid arthritis treatment. To investigate the therapeutic mechanism of a traditional ...
Shetty Shishir Ram SR Department of Oral Medicine and Radiology, AB Shetty Memorial Institute of Dental Science, Mangalore, Karnataka, - - 2014
Lipid oxidation gives rise to number of secondary by-products. Malondialdehyde (MDA) is the principal and most widely studied product of polyunsaturated fatty acid peroxidation. This aldehyde is a highly toxic molecule and should be considered as more than just a marker of lipid peroxidation in oral carcinogenesis. Salivary malondiadldehyde was ...
Young Ben B Queen Elizabeth Hospital, Gayton Road, King's Lynn, Norfolk PE30 4ET, - - 2014
To record the current use of tranexamic acid during traumatic haemorrhage and elective arthroplasty of the hip and knee. A questionnaire-based postal survey. The questionnaire was sent to the 'anaesthetic lead' at all acute trusts in England, excluding centres for children, women's health, cancer and cardiac care. Ninety-nine (66%) centres ...
Cascão Rita R Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, - - 2014
Background. We have previously reported a continuous activation of caspase-1 and increased interleukin (IL)-1 β levels in early rheumatoid arthritis (RA). These observations raised the hypothesis that drugs targeting the IL-1 β pathway, in addition to tumour necrosis factor (TNF), may be particularly effective for early RA treatment. We have ...
Asano Marie M Department of Chemistry, Wakayama Medical University, 580 Mikazura, Wakayama 641-0011, Japan. - - 2014
We examined the effects of caffeic acid (CA) and related compounds on 7-carboxyheptyl radical formation. This analysis was performed using a standard D2O reaction mixture containing 4.3 mM oleic acid, 25 μM flavin mononucleotide (FMN), 160 mM phosphate buffer (pH 7.4), 10 mM cholic acid, 100 mM α-(4-pyridyl-1-oxide)-N-tert-butylnitrone, and 1 ...
Galili Gad G Department of Plant Sciences, The Weizmann Institute of Science Rehovot, - - 2014
Seeds are the major organs responsible for the evolutionary upkeep of angiosperm plants. Seeds accumulate significant amounts of storage compounds used as nutrients and energy reserves during the initial stages of seed germination. The accumulation of storage compounds requires significant amounts of energy, the generation of which can be limited ...
Golalipour Mohammad Jafar MJ 1. PhD, Professor, Gorgan Congenital Malformations Research Center, Golestan University of Medical Sciences, Gorgan, Iran. - - 2014
Background Several studies have examined the effects of folic acid fortification on the occurrence of orofacial clefts. This study was carried out to evaluate the impact of flour fortification with folic acid on oral clefts in Northern Iran. In this hospital based study from March 2006 to September 2009, we ...
Qu L J LJ Department of Entomology, China Agricultural University, Yuanmingyuan West Rd., Beijing 100193, China The Key Laboratory of Forest Protection, State Forestry Administration, Research Institute of Forest Ecology, Environment and Protection, Chinese Academy of Forestry, Beijing 100091, - - 2014
Radiation-induced sterile insect technique is a biologically based, environment-friendly method for the suppression or eradication of a number of insect pests. Although the basic mechanisms underlying the technology have been well studied, little is known about the cell responses in organisms. Characterization of the metabolic shift associated with radiation exposure ...
Tokikawa Rita - - 2013
Abstract Highly electrophilic α-dicarbonyls such as diacetyl, methylglyoxal, 3-deoxyglucosone and4,5-dioxovaleric acid have been characterized as secondary catabolites that can aggregate proteins and form DNA nucleobase adducts in several human maladies, including Alzheimer's disease, rheumatoid arthritis, diabetes, sepsis, renal failure, and respiratory distress syndrome. In vitro, diacetyl and methylglyoxal have also ...
Frommer Klaus W - - 2013
Due to their role in inflammatory metabolic diseases, we hypothesised that free fatty acids (FFA) are also involved in inflammatory joint diseases. To test this hypothesis, we analysed the effect of FFA on synovial fibroblasts (SF), human chondrocytes and endothelial cells. We also investigated whether the toll-like receptor 4 (TLR4), ...
Dahuja Anshul - - 2013
Total knee arthroplasty(TKA) is associated with extensive postoperative blood loss. Despite various studies proving the efficacy of Tranexamic Acid (TEA) with single or multiple boluses of different sizes with or without subsequent infusions, no consensus has been reached on the dose of tranexamic acid to be administered or the duration ...
Bilthariya Upasana - - 2013
Abstract Objective: The present study discusses folic acid-etoricoxib-bovine serum albumin nanoparticles (F-ETX-NPs) using folic acid as an over expressed folate receptor ligand for activated macrophages in targeting of rheumatoid arthritis. Materials and methods: For this purpose etoricoxib-loaded BSA nanoparticles (ETX-NPs) were prepared by desolvation method and activated folic acid conjugation ...
Lenski Markus - - 2013
Septic and gouty arthritis show the same clinical symptoms, but septic arthritis is an orthopedic emergency and needs immediate surgical intervention, whereas a systemic drug therapy is needed in acute gouty arthritis. The aim of this study was to investigate which inflammatory markers allow an accurate differentiation of septic and ...
Sarithakumari C H CH Department of Biochemistry, University of Kerala, Kariavattom Campus, Trivandrum, Kerala 695881, - - 2013
The present study evaluated the anti-inflammatory potential of alginic acid isolated from the brown algae Sargassum wightii in type II collagen induced arthritic rats, a well established arthritic model that resembles more closely to human rheumatoid arthritis in its clinical, pathological, immunological and histological aspects. Type II collagen induced arthritic ...
Martin Joseph G - - 2013
Major blood loss is a known potential complication in total hip and total knee arthroplasty. We conducted a prospective, stratified, randomized, double-blind, placebo-controlled trial that evaluated 100 patients undergoing total knee or total hip arthroplasty to evaluate the effect on blood loss using the topical application of tranexamic acid. Participants ...
Gilbody Julian - - 2013
The efficaciousness of topical tranexamic acid use at the end of knee arthroplasty surgery to reduce blood loss and transfusion requirements has previously been shown. The aim of this study was to retrospectively assess the effectiveness of topical tranexamic acid use, comparing 155 patients undergoing hip and knee arthroplasty surgery ...
- - 2013
A meta-analysis of 89 randomised trials suggests that, at best, intraarticular hyaluronic acid injection only provides a small relief to patients with osteoarthritis of the knee, but that it can provoke both local reactions and serious adverse effects.
Chimento George F - - 2013
The purpose of this study was to evaluate the effectiveness of topical tranexamic acid in primary TKA from a clinical and economic standpoint. We retrospectively reviewed 683 primary total knee arthroplasties performed at a single institution over a 2-year period. We compared 373 cases performed in 2010 without tranexamic acid ...
Lee Ae Li - - 2013
Background: Rheumatoid arthritis (RA) is one of the most common autoimmune diseases that result in chronic inflammation of the joints. n-3 polyunsaturated fatty acids (PUFAs) have been suggested to play a role in the pathogenesis and clinical course of RA. The purpose of the present study was to investigate whether ...
Mine T - - 2013
PURPOSE. To examine changes in acid mucopolysaccharides and collagen expression during meniscal degeneration, tearing, and repair, using menisci excised from knee joint surgeries. METHODS. Menisci excised from 23 patients aged 15 to 80 years who underwent meniscal surgery for flap and bucket handle tears (n=11) and total knee arthroplasty (TKA) ...
Printz Jonathon O - - 2013
The search results of a recent systematic review of prospective, randomized, placebo-controlled trials on hyaluronic acid injections for knee arthritis were updated and reviewed for funding source and qualitative conclusions. Forty-eight studies were identified; 30 (62.5%) were industry funded, and 3 (6.25%) were not. Fifteen (31.3%) studies did not identify ...
Gierman L M - - 2013
Objective: The infrapatellar fat pad (IPFP) in the knee joint is hypothesized to contribute to osteoarthritis (OA) development possibly by influencing inflammatory processes. Oxylipins are essential mediators in the inflammatory process. We aimed to identify the secretion of fatty acids and oxylipins derived thereof by the IPFP. Methods: IPFP explants ...
Bruce-Brand Robert - - 2013
Tranexamic acid has been shown to reduce perioperative blood loss without increasing the risk of venous thromboembolism after total knee replacement. However studies to date were designed to assess efficacy as the primary outcome and were not powered to assess safety. We report the case of a 65-year-old male with ...
Yu Feng - - 2013
In order to mimic the natural cartilage extracellular matrix, a novel biological degradable interpenetrating network hydrogel was synthesized from the gelatin (G), hyaluronic acid (HA) and chondroitin sulfate (CS) by Diels-Alder "click" chemistry. HA was modified with furylamine and G was modified with furancarboxylic acid respectively. (1)H NMR spectra and ...
Du Longfei - - 2013
In previously published articles, we evaluated the toxicity of four organophosphate (OP) pesticides (dichlorvos, dimethoate, acephate and phorate) to rats using metabonomic technology at their corresponding no observed adverse effect level (NOAEL). Results show that a single pesticide elicits no toxic response. The present study aimed to determine whether chronic ...
Enjo Mitsuhiro M Department of Plastic and Reconstructive Surgery, Kinki University Faculty of Medicine, Osaka, - - 2013
Approaches to auricular reconstruction have shown improved outcome when a basic fibroblast growth factor (bFGF) slow-release system and fibrin spraying are combined with biodegradable polymers. More complex, three-dimensional structures, such as those that replicate the human auricle, are often lost because of biodegradation of the synthetic scaffold. To improve the ...
Norling Lucy V - - 2013
Omega-3 polyunsaturated fatty acids (PUFAs) are known to alleviate joint stiffness and pain in rheumatoid arthritis patients. However, the mechanisms by which omega-3s exert their beneficial effects has not been fully explored. Herein we discuss a novel class of bioactive lipid mediators, which are enzymatically biosynthesized in vivo from omega-3 ...
Pachauri Amit - - 2013
The aim of this study was to evaluate the efficacy of perioperative administration of 1,4-amino-carboxylic acid (tranexamic acid) in reducing the intraoperative and postoperative blood loss in patients undergoing total knee replacement (TKR). Tranexamic acid is an antifibrinolytic agent that is 7-10 times as potent as epsilon aminocaproic acid. We ...
Park Yongsoon - - 2013
N-3 polyunsaturated fatty acids (PUFA) have anti-inflammatory effects and may be useful for the treatment of inflammatory diseases such as rheumatoid arthritis (RA).We examined the efficacy of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) supplementation on RA on top of standard anti-inflammatory treatment. Patients with RA were randomized into two ...
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