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Lindgren Ola O Lund University, Department of Clinical Sciences, Lund, Medicine, - - 2014
Context: The incretin effect is the augmented insulin secretion by oral versus intravenous glucose at matching glucose levels. We previously demonstrated an augmented insulin secretion when fat is given orally rather than intravenously, suggesting an incretin effect also after fat. However, whether there is an incretin effect is also present ...
Krusong W W Fermentation Technology Division, Faculty of Agro-Industry, King Mongkut's Institute of Technology Ladkrabang, Chalongkrung Rd., Ladkrabang District, Bangkok, 10520, - - 2014
To evaluate the comparative impact of high initial concentrations of acetic acid (AAi ) and of ethanol (ETi ) on acetification rate (ETA). Acetic acid bacteria (AAB) were cultivated in a 100 l internal Venturi injector bioreactor. To quantify the oxygen availability, the 1.0 l min(-1) air in-flow rate for ...
Astarita Giuseppe G Waters Corporation, Milford, MA, USA; Department of Biochemistry and Molecular & Cellular Biology, Georgetown University, Washington, DC, USA. Electronic address: - - 2014
Oxidation of polyunsaturated fatty acids (PUFA) through enzymatic or non-enzymatic free radical-mediated reactions can yield an array of lipid metabolites including eicosanoids, octadecanoids, docosanoids and related species. In mammals, these oxygenated PUFA mediators play prominent roles in the physiological and pathological regulation of many key biological processes in the cardiovascular, ...
Mathew Sindhu S Institute of Bioproduct Development, Universiti Teknologi Malaysia (UTM), 81310, Johor Bahru, Johor, Malaysia, - - 2014
Pyroligneous acid (PA) is a complex highly oxygenated aqueous liquid fraction obtained by the condensation of pyrolysis vapors, which result from the thermochemical breakdown or pyrolysis of plant biomass components such as cellulose, hemicellulose, and lignin. PA produced by the slow pyrolysis of plant biomass is a yellowish brown or ...
Jost Benjamin B Umwelt- und Biotechnologisches Zentrum (UBZ), Helmholtz-Zentrum für Umweltforschung - UFZ, Permoserstraße 15, 04318, Leipzig, Germany, - - 2014
The yeast Yarrowia lipolytica is able to produce high amounts of several organic acids such as pyruvic, citric, isocitric, alpha-ketoglutaric, and succinic acid. Here we report on the influence of the reduced activity of succinate dehydrogenase in Y. lipolytica on its ability to produce succinate. The recombinant strains Y. lipolytica ...
Koopman Jessica E JE Department of Preventive Dentistry, Academic Centre for Dentistry Amsterdam, University of Amsterdam, Gustav Mahlerlaan 3004, 1081 LA, Amsterdam, The Netherlands, - - 2014
Dysbiosis induced by low pH in the oral ecosystem can lead to caries, a prevalent bacterial disease in humans. The amino acid arginine is one of the pH-elevating agents in the oral cavity. To obtain insights into the effect of arginine on oral microbial ecology, a multi-plaque "artificial mouth" (MAM) ...
Dumoulin Audrey A Centre de Recherche de Gif, Institut de Chimie des Substances Naturelles, CNRS, 91198 Gif-sur-Yvette Cedex, France. - - 2014
Amination of enecarbamates with dibenzylazodicarboxylate and oxygenated nucleophiles in the presence of a catalytic amount of chiral phosphoric acid afforded optically active stable precursors of α-hydrazinoimines, which were reduced or oxidized, respectively, to vicinal diamines or α-amino acid precursors with excellent yield and enantioselectivity.
Husar Richard - - 2014
The reducing conditions in a nuclear waste repository render neptunium tetravalent. Thus, Np is often assumed to be immobile in the subsurface. However, tetravalent actinides can also become mobile if they occur as colloids. We show that Np(IV) is able to form silica-rich colloids in solutions containing silicic acid at ...
Galano Jean-Marie JM Institut des Biomolécules Max Mousseron (IBMM), UMR 5247, CNRS, University Montpellier I and II, ENSCM, Faculty of Pharmacy, Montpellier, - - 2014
Cyclic oxygenated metabolites are formed in vivo through non-enzymatic free radical reaction of n-6 and n-3 polyunsaturated fatty acids (PUFAs) such as arachidonic (ARA C20:4 n-6), adrenic (AdA 22:4 n-6), α-linolenic (ALA 18:3 n-3), eicosapentaenoic (EPA 20:5 n-3) and docosahexaenoic (DHA 22:6 n-3) acids. These cyclic compounds are known as ...
Wang Yang Y State Key Laboratory of Coordination Chemistry, Center for Multimolecular Organic Chemistry, School of Chemistry and Chemical Engineering, Nanjing University , Nanjing 210093, - - 2014
An effective Pd-catalyzed hydrocarboxylation of olefins with phenyl formate and formic acid is described. A variety of carboxylic acids are obtained in good yields with high regioselectivities under operationally simple conditions without the use of toxic CO gas.
Sattler Johann H JH Institut für Chemie, Organische und Bioorganische Chemie, University of Graz, Heinrichstrasse 28, 8010 Graz (Austria); Austrian Centre of Industrial Biotechnology (ACIB), Petersgasse 14, 8010 Graz - - 2014
The combination of two cofactor self-sufficient biocatalytic cascade modules allowed the successful transformation of cyclohexanol into the nylon-6 monomer 6-aminohexanoic acid at the expense of only oxygen and ammonia. A hitherto unprecedented carboxylic acid capping strategy was introduced to minimize the formation of the dead-end intermediate 6-hydroxyhexanoic acid. For this ...
Wang Yuan Y State Key Joint Laboratory of Environmental Simulation and Pollution Control, School of Environment, Tsinghua University, Beijing 100084, China; School of Chemistry and Chemical Engineering, Guizhou University, Guiyang, Guizhou 550025, China. Electronic address: - - 2014
Perfluorooctanoic acid (PFOA), a persistent organic pollutant, receives increasing concerns due to its worldwide occurrence and resistance to most conventional treatment processes. The photochemical decomposition by 185nm vacuum ultraviolet (VUV) is one of the efficient methods for PFOA decomposition. The effects of pH on PFOA decomposition in nitrogen atmosphere or ...
Kaiser Ralf I RI Department of Chemistry, W. M. Keck Research Laboratory in Astrochemistry, University of Hawaii at Manoa, 2545 McCarthy Mall, Honolulu, HI 96822 (USA). - - 2014
Contemporary mechanisms for the spontaneous formation of glycerol have not been able to explain its existence on early Earth. The exogenous origin and delivery of organic molecules to early Earth presents an alternative route to their terrestrial in situ formation since biorelevant molecules like amino acids, carboxylic acids, and alkylphosphonic ...
Kong Xiangli X State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, P.R. - - 2015
The aim of the present study was to identify time-dependent changes in the expression of metabolic biomarkers during the various stages of oral carcinogenesis to provide an insight into the sequential mechanism of oral cancer development. An (1)H nuclear magnetic resonance (NMR)-based metabolomics approach was used to analyze the blood ...
Jaušovec D D University of Maribor, Institute for Engineering Materials and Design, Smetanova Ulica 17, SI-2000 Maribor, - - 2015
The adsorption of chemically similar but differently oxygen reactive phenolic-acid derivatives on the Ti-nanotubes (TiNTs) surfaces to increase and/or broaden their photo-induced activity was studied using Raman and X-ray photoelectron spectroscopies combined with zeta-potential analyses. Photo-catalytic activities and stabilities of newly synthesized particles were evaluated by using high-resolution capillary electrophoresis ...
Shi Zhi-Hao ZH Nanjing University of Chinese Medicine, National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine , 138 Xianlin Road, Nanjing 210023, Jiangsu , PR China +86 25 85811916 ; +86 25 85811916 ; linianguang@njutcm.edu.cn , - - 2014
Thrombotic disorders can lead to deep vein thrombosis, myocardial infarction and stroke. Thrombin plays a vital role in cascade reaction of blood coagulation, inhibition of the activity of thrombin can block the formation of thrombus and direct thrombin inhibitor has a prospect to overcome the limitations in application of the ...
Wang Lin L Department of Chemistry, Zhejiang University, Hangzhou, 310027, Zhejiang, - - 2014
The noncovalent complex interactions between cyclofructans, a new class of cyclic oligosaccharide hosts, and various amino acids have been characterized by means of electrospray ionization mass spectrometry and nuclear magnetic resonance. The 1 : 1 stoichiometry of cyclofructans and amino acid complexes was confirmed by their mass-to-charge ratio in positive mode. Cyclofructans ...
Guichardant Michel M Université de Lyon, UMR 1060 Inserm (CarMeN), UMR 1397 INRA, INSA-Lyon, IMBL, Villeurbanne, France. Electronic address: - - 2014
Numerous epidemiological studies and clinical trials have reported the health benefits of omega-3 polyunsaturated fatty acids (PUFA), including a lower risk of coronary heart diseases. This review mainly focuses on the effects of alpha-linolenic (ALA), eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids on some risk factors associated with atherothrombosis, including platelet ...
Unni Sreekuttan M SM Physical and Materials Chemistry Division, CSIR-National Chemical Laboratory, Pune, Maharashtra-411008, India. - - 2014
Layer-separated 3D nitrogen doped graphene (NG) with an accessible interstitial surface and modulated activity characteristics for oxygen reduction in acidic medium could be prepared by wrapping NG sheets on in situ generated carbon nitride (CNx) tetrapods.
Gheerardijn Vicky V Department of Organic Chemistry, Gent University, Krijgslaan 281, 9000 Gent - - 2014
SCNAC, the XVIth Symposium on Chemistry of Nucleic Acid Components, was held in Český Krumlov (Czech Republic) in June. This year's symposium, which covered the chemistry, biochemistry, biophysics and chemical biology of nucleobases, nucleosides, nucleotides and nucleic acids attracted more than 150 participants from 21 countries to its lectures, oral ...
Alkorta Ibon I Instituto de Química Médica, CSIC, Juan de la Cierva, 3, 28006 Madrid (Spain), Fax: (+34) 91-5644853. - - 2014
Several convergent techniques were used to characterize 1,1'-bi-2-naphthol (BINOL) and some of its properties. Its acidity in the gas-phase, from neutral species to monoanion, was measured by mass spectrometry. The conformation and structure of BINOL in the gas phase was determined by microwave rotational spectroscopy. NMR experiments in fluorosulfonic acid ...
Zhou Min M Key Laboratory of Tobacco Chemistry of Yunnan Province, China Tobacco Yunnan Industrial Co., Ltd. , Kunming 650231, People's Republic of - - 2014
Aspergillines A-E (1-5) are highly oxygenated cyclopiazonic acid (CPA)-derived alkaloids bearing a rigid and sterically congested hexacyclic indole-tetrahydrofuran-tetramate scaffold, isolated from the endophytic fungus Aspergillus vesicolor. Apergillines A-C represent a new subclass of CPA-derived alkaloids, and aspergillines B and E possess a butanoic acid methyl ester moiety. The structures, including ...
Ren Ang A Key Laboratory of Microbiological Engineering of Agricultural Environment, Ministry of Agriculture, Microbiology Department, College of Life Sciences, Nanjing Agricultural University, Nanjing, 210095, Jiangsu, People's Republic of - - 2014
Acetic acid at 5-8 mM increased ganoderic acid (GA) accumulation in Ganoderma lucidum. After optimization by the response surface methodology, the GA content reached 5.5/100 mg dry weight, an increase of 105 % compared with the control. The intermediate metabolites of GA biosynthesis, lanosterol and squalene also increased to 47 and 15.8 μg/g dry ...
Santhanaraj Daniel D School of Chemical, Biological and Materials Engineering, University of Oklahoma, 100 E. Boyd Street, Room T301 Norman, OK 73019 - - 2014
Fast pyrolysis of biomass to produce a bio-oil followed by catalytic upgrading is a widely studied approach for the potential production of fuels from biomass. Because of the complexity of the bio-oil, most upgrading strategies focus on removing oxygen from the entire mixture to produce fuels. Here we report a ...
Assemany Paula Peixoto - - 2014
The objective of this paper is to compare the lipid content and composition ofbiomass produced by a consortium of microalgae and bacteria, cultivated under different solar radiation intensities and tropical conditions in pilot-scale high-rate ponds (HRPs) using domestic sewage as culture medium. The treatment system consisted of an upflow anaerobic ...
Ge Xiang-Yang - - 2014
This study describes a novel strategy to regulate metabolic flux for lactic acid production in Lactobacillus casei. The ldhL gene encoding L-lactate dehydrogenase (L-LDH) was overexpressed in the L. casei, and a two-stage oxygen supply strategy (TOS) that maintained medium oxygen supply level (MOS) during early fermentation phase, and low ...
Garzon Andres - - 2014
The mechanism and kinetics of reactions between coumaric acids and a series of reactive oxygen species (•OX) was studied through the Density Functional Theory (DFT). H-atom abstraction from -OH and -COOH groups and addition to the non-aromatic double bond were the most representative reaction pathways chosen for which free energy ...
Choe Jung-Yoon JY Devision of Rheumatology, Department of Internal Medicine, Arthritis & Autoimmunity Research Center, Catholic University of Daegu School of Medicine, Daegu, Republic of - - 2014
The association between serum uric acid concentrations and inflammation in patients with rheumatoid arthritis (RA) has been still controversial. A total of 172 patients with RA who added leflunomide to methotrexate (MTX) in their treatment regimens were enrolled in this study. Twenty-seven RA patients taking MTX without leflunomide were also ...
Adams Sarah E SE School of Chemistry, Main Building, Cardiff University, Park Place, Cardiff, CF10 3AT, - - 2014
Excessive activity of neutrophils has been linked to many pathological conditions, including rheumatoid arthritis, cancer and Alzheimer's disease. Calpain-I is a Ca(2+)-dependent protease that plays a key role in the extravasation of neutrophils from the blood stream prior to causing damage within affected tissues. Inhibition of calpain-I with small molecule ...
Dadhich M - - 2014
Background: Aberrant glycosylation is the universal feature of cancer and components of various glycoconjugates, such as sialic acid is found to rise in various malignancies. The objective of this study was to evaluate the serum and salivary sialic acid in oral potentially malignant disorders (OPMD) and oral cancer (OC) to ...
Shin Jung Min JM School of Chemical Engineering, College of Engineering, Sungkyunkwan University, Suwon 440-746, Republic of Korea. - - 2014
In an effort to improve the therapeutic efficacy of methotrexate (MTX), we prepared the hyaluronic acid-MTX conjugate for targeted therapy of rheumatoid arthritis (RA). Owing to the pH-sensitive nature of the conjugate, MTX was rapidly released under the mildly acidic conditions, similar to the environment of inflamed synovial tissue in ...
Meek Inger L - - 2014
Gout and hyperuricaemia may be associated with increased cardiovascular risk, but analyses in different populations show conflicting results. This study investigates the impact of serum uric acid, inflammation and traditional CV risk parameters on CV event risk in patients with gouty arthritis and patients with non-gouty rheumatic disease. cross-sectional and ...
Soni Ashwani A Department of Orthopaedics, GGS Medical College and Hospital, Faridkot, - - 2014
Tranexamic acid is an antifibrinolytic drug used widely to prevent bleeding. Its use in reducing bleeding during total knee arthroplasty surgery is well proven but there is no final consensus regarding the regimen. The purpose of our study was to compare the effectiveness of intravenous and intra-articular regimen of tranexamic ...
Zhang Huawei H School of Pharmacy, Second Military Medical University, Shanghai 200433, P.R. - - 2014
Huang-Lian-Jie-Du-Tang (HLJDT oren-gedoku-to in Japanese), a classical traditional Chinese medicine (TCM) formula, is well known for the treatment of inflammatory-related diseases such as gastritis, dermatitis, and ulcerative colitis. Our previous studies have indicated that HLJDT has therapeutic potential in rheumatoid arthritis treatment. To investigate the therapeutic mechanism of a traditional ...
Shetty Shishir Ram SR Department of Oral Medicine and Radiology, AB Shetty Memorial Institute of Dental Science, Mangalore, Karnataka, - - 2014
Lipid oxidation gives rise to number of secondary by-products. Malondialdehyde (MDA) is the principal and most widely studied product of polyunsaturated fatty acid peroxidation. This aldehyde is a highly toxic molecule and should be considered as more than just a marker of lipid peroxidation in oral carcinogenesis. Salivary malondiadldehyde was ...
Young Ben B Queen Elizabeth Hospital, Gayton Road, King's Lynn, Norfolk PE30 4ET, - - 2014
To record the current use of tranexamic acid during traumatic haemorrhage and elective arthroplasty of the hip and knee. A questionnaire-based postal survey. The questionnaire was sent to the 'anaesthetic lead' at all acute trusts in England, excluding centres for children, women's health, cancer and cardiac care. Ninety-nine (66%) centres ...
Cascão Rita R Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, - - 2014
Background. We have previously reported a continuous activation of caspase-1 and increased interleukin (IL)-1 β levels in early rheumatoid arthritis (RA). These observations raised the hypothesis that drugs targeting the IL-1 β pathway, in addition to tumour necrosis factor (TNF), may be particularly effective for early RA treatment. We have ...
Asano Marie M Department of Chemistry, Wakayama Medical University, 580 Mikazura, Wakayama 641-0011, Japan. - - 2014
We examined the effects of caffeic acid (CA) and related compounds on 7-carboxyheptyl radical formation. This analysis was performed using a standard D2O reaction mixture containing 4.3 mM oleic acid, 25 μM flavin mononucleotide (FMN), 160 mM phosphate buffer (pH 7.4), 10 mM cholic acid, 100 mM α-(4-pyridyl-1-oxide)-N-tert-butylnitrone, and 1 ...
Galili Gad G Department of Plant Sciences, The Weizmann Institute of Science Rehovot, - - 2014
Seeds are the major organs responsible for the evolutionary upkeep of angiosperm plants. Seeds accumulate significant amounts of storage compounds used as nutrients and energy reserves during the initial stages of seed germination. The accumulation of storage compounds requires significant amounts of energy, the generation of which can be limited ...
Golalipour Mohammad Jafar MJ 1. PhD, Professor, Gorgan Congenital Malformations Research Center, Golestan University of Medical Sciences, Gorgan, Iran. - - 2014
Background Several studies have examined the effects of folic acid fortification on the occurrence of orofacial clefts. This study was carried out to evaluate the impact of flour fortification with folic acid on oral clefts in Northern Iran. In this hospital based study from March 2006 to September 2009, we ...
Qu L J LJ Department of Entomology, China Agricultural University, Yuanmingyuan West Rd., Beijing 100193, China The Key Laboratory of Forest Protection, State Forestry Administration, Research Institute of Forest Ecology, Environment and Protection, Chinese Academy of Forestry, Beijing 100091, - - 2014
Radiation-induced sterile insect technique is a biologically based, environment-friendly method for the suppression or eradication of a number of insect pests. Although the basic mechanisms underlying the technology have been well studied, little is known about the cell responses in organisms. Characterization of the metabolic shift associated with radiation exposure ...
Tokikawa Rita - - 2013
Abstract Highly electrophilic α-dicarbonyls such as diacetyl, methylglyoxal, 3-deoxyglucosone and4,5-dioxovaleric acid have been characterized as secondary catabolites that can aggregate proteins and form DNA nucleobase adducts in several human maladies, including Alzheimer's disease, rheumatoid arthritis, diabetes, sepsis, renal failure, and respiratory distress syndrome. In vitro, diacetyl and methylglyoxal have also ...
Frommer Klaus W - - 2013
Due to their role in inflammatory metabolic diseases, we hypothesised that free fatty acids (FFA) are also involved in inflammatory joint diseases. To test this hypothesis, we analysed the effect of FFA on synovial fibroblasts (SF), human chondrocytes and endothelial cells. We also investigated whether the toll-like receptor 4 (TLR4), ...
Dahuja Anshul - - 2013
Total knee arthroplasty(TKA) is associated with extensive postoperative blood loss. Despite various studies proving the efficacy of Tranexamic Acid (TEA) with single or multiple boluses of different sizes with or without subsequent infusions, no consensus has been reached on the dose of tranexamic acid to be administered or the duration ...
Bilthariya Upasana - - 2013
Abstract Objective: The present study discusses folic acid-etoricoxib-bovine serum albumin nanoparticles (F-ETX-NPs) using folic acid as an over expressed folate receptor ligand for activated macrophages in targeting of rheumatoid arthritis. Materials and methods: For this purpose etoricoxib-loaded BSA nanoparticles (ETX-NPs) were prepared by desolvation method and activated folic acid conjugation ...
Lenski Markus - - 2013
Septic and gouty arthritis show the same clinical symptoms, but septic arthritis is an orthopedic emergency and needs immediate surgical intervention, whereas a systemic drug therapy is needed in acute gouty arthritis. The aim of this study was to investigate which inflammatory markers allow an accurate differentiation of septic and ...
Sarithakumari C H CH Department of Biochemistry, University of Kerala, Kariavattom Campus, Trivandrum, Kerala 695881, - - 2013
The present study evaluated the anti-inflammatory potential of alginic acid isolated from the brown algae Sargassum wightii in type II collagen induced arthritic rats, a well established arthritic model that resembles more closely to human rheumatoid arthritis in its clinical, pathological, immunological and histological aspects. Type II collagen induced arthritic ...
Martin Joseph G - - 2013
Major blood loss is a known potential complication in total hip and total knee arthroplasty. We conducted a prospective, stratified, randomized, double-blind, placebo-controlled trial that evaluated 100 patients undergoing total knee or total hip arthroplasty to evaluate the effect on blood loss using the topical application of tranexamic acid. Participants ...
Gilbody Julian - - 2013
The efficaciousness of topical tranexamic acid use at the end of knee arthroplasty surgery to reduce blood loss and transfusion requirements has previously been shown. The aim of this study was to retrospectively assess the effectiveness of topical tranexamic acid use, comparing 155 patients undergoing hip and knee arthroplasty surgery ...
- - 2013
A meta-analysis of 89 randomised trials suggests that, at best, intraarticular hyaluronic acid injection only provides a small relief to patients with osteoarthritis of the knee, but that it can provoke both local reactions and serious adverse effects.
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