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Results 451 - 500 of 2672
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Xie Zhuohong - - 2011
To determine the possible alternative use of tobacco, the seeds representing seven Maryland tobacco cultivars were investigated for their phytochemical, antioxidant and anti-proliferative properties. Tobacco seed oils were extracted by the soxhlet method, and analyzed for their yield, density, refractive index, fatty acid profiles and tocopherol profile. The defatted flours ...
Inns Elizabeth L - - 2011
Barley phenolic antioxidants change in response to the kilning regimen used to prepare malt. Green malt was kilned using 4 different regimens. There were no major differences among the finished malts in parameters routinely used by the malting industry, including, moisture, color, and diastatic activity. Ferulic acid esterase activity and ...
Naranmandura Hua - - 2011
Human bladder is one of the primary target organs for arsenic-induced carcinogenicity, and arsenic metabolites in urine have been suspected to be directly involved in carcinogenesis. Thioarsenicals are commonly found in human and animal urine, and also considered to be highly toxic arsenic metabolites. The present study was performed to ...
Feng Jiafu - - 2011
The objective of this paper is to calculate the shelf life of ascorbic acid solution under given conditions by using a mathematical model. An antioxidant, sodium metabisulfite, was added to the ascorbic acid solution. The kinetic parameters of the degradation reaction of ascorbic acid and sodium metabisulfite, were investigated, respectively, ...
Jun Dae Won - - 2011
Mitochondria are the main sites for fatty acid oxidation and play a central role in lipotoxicity and nonalcoholic steatohepatitis. We investigated whether carnitine prevents free fatty acid (FFA)-induced lipotoxicity in vitro and in vivo. HepG2 cells were incubated with FFA, along with carnitine and carnitine complexes. Mitochondrial β-oxidation, transmembrane potential, ...
Faller Robert V - - 2011
To determine the relative ability of various marketed toothpastes formulated with either stabilized stannous fluoride (SnF2), sodium fluoride (NaF), or sodium monofluorophosphate (SMFP) to protect human enamel against the initiation and progression of damage due to dietary acid attack, using a laboratory erosion cycling model. Cores of ground and polished ...
Külkamp Irene C - - 2011
Lipoic acid is a widely studied substance, whose therapeutic effects are related to its antioxidant activity. Our objective was to develop lipoic acid-loaded lipid-core nanocapsules and evaluate their in vitro antioxidant effect against lipid peroxidation induced by ascorbyl free radicals, using soybean lecithin liposomes as the substrate. The nanocapsule suspensions ...
Saul Nadine - - 2011
The model organism Caenorhabditis elegans was utilized to determine, in vivo, the mode(s) of action of four plant polyphenols, namely, tannic acid (TA), gallic acid (GA), ellagic acid (EA), and catechin (CT). The determination of lifespan, stress resistance, growth, reproduction, eating-related behaviors, antioxidative capacities, and lifespan assays with the mev-1 ...
Hassan Fouad Abdulrahman - - 2011
Phenolic compounds and antioxidant capacity of methanolic extract prepared from fully ripe bambangan (Mangifera pajang K.) peel cultivated in Sarawak, Malaysia were analyzed. The total phenolic content (98.3 mg GAE/g) of bambangan peel powder (BPP) was determined by the Folin-Ciocalteu method. BPP showed a strong potency of antioxidant activity and ...
Kwak Seon-Yeong - - 2011
Anti-aging and depigmentation have both been an important subject of study for skin disease and the cosmetic industry. Caffeic acid (CA) has shown synergistically enhanced antioxidant activity when conjugated with amino acids. Hydroxamic acid (NHOH) is a well-known metal chelator, potentially having both tyrosinase inhibitory activity and free radical scavenging ...
Matsui Hirofumi - - 2011
BACKGROUND: Gastric hydrochloric acid (HCl) has been regarded as an inciting factor in gastric mucosal injuries and has been reported to induce lipid peroxidation in vitro. However, because HCl is not an oxidant per se, the exact mechanism by which the acid induces lipid peroxidation is unknown. We hypothesized that ...
Dangate Prasad S - - 2011
Rational exploration directed by DFT (density functional theory) based atomic Fukui indices, lead to development of regioselective oxidation of cholic acid and its 7β epimer by o-iodoxybenzoic acid. In case of cholic acid only, 7α-hydroxyl underwent oxidation, where as in its 7β epimer the selectivity was towards 12α-hydroxy group. Since ...
Magalhães Juliana G - - 2011
Abstract Objective. The aim of this study was to assess the enamel microhardness treated with three in-office bleaching agents, containing 35% hydrogen peroxide with different acidity. Materials and methods. Bovine incisors were divided into three groups that received the following bleaching agents: Whiteness HP, Total Bleach and Opalescence Xtra. Three ...
Matsui Kei - - 2011
Mycosporine-like amino acids (MAAs) are UV absorbing pigments, and structurally distinct MAAs have been identified in taxonomically diverse organisms. Two novel MAAs were purified from the cyanobacterium Nostoc commune, and their chemical structures were characterized. An MAA with an absorption maximum at 335nm was identified as a pentose-bound porphyra-334 derivative ...
Barrasa Juan Ignacio - - 2011
The continuous exposure of the colonic epithelium to high concentrations of bile acids may exert cytotoxic effects and has been related to pathogenesis of colon cancer. A better knowledge of the mechanisms by which bile acids induce toxicity is still required and may be useful for the development of new ...
Moretti Morgana - - 2011
Clinical and preclinical data reported that ascorbic acid has antidepressant properties. The present study was designed to investigate the participation of l-arginine-NO-cGMP pathway in the antidepressant-like effect of ascorbic acid in the tail suspension test (TST) in mice. The antidepressant-like effect of ascorbic acid (1mg/kg, p.o.) in the TST was ...
Cornejo Alberto - - 2011
Alzheimer's disease is a neurodegenerative disorder involving extracellular plaques (amyloid-β) and intracellular tangles of tau protein. Recently, tangle formation has been identified as a major event involved in the neurodegenerative process, due to the conversion of either soluble peptides or oligomers into insoluble filaments. At present, the current therapeutic strategies ...
He Long - - 2011
A variety of chiral bisphosphoric acids derived from binaphthols have been evaluated for enantioselective 1,3-dipolar cycloaddition reactions, revealing that the feature of the linker in the catalysts exerted great impact on the stereoselectivity. Among them, the oxygen-linked bisphosphoric acid 1a provided the highest level of stereoselectivity for the 1,3-dipolar cycloaddition ...
Bhouri Wissem - - 2011
The antioxidant and apoptotic activities of digallic acid, isolated from the fruits of Pistascia lentiscus, were investigated. The study demonstrated that digallic acid possessed pro-apoptotic effects, as shown by provoking DNA fragmentation of K562 cells. It also revealed a significant antioxidant potential and effective scavenging activity against 2,2-diphenyl-1-picrylhdrazyl (DPPH(·) ) ...
Oyanagi Eri - - 2011
Cardiovascular risks are frequently accompanied by high serum fatty acid levels. Although recent studies have shown that fatty acids affect mitochondrial function and induce cell apoptosis, l-carnitine is essential for the uptake of fatty acids by mitochondria, and may attenuate the mitochondrial dysfunction and apoptosis of cardiocytes. This study aimed ...
Wang Huifen - - 2011
Pentadecanoic acid (15:0) and heptadecanoic acid (17:0), the dairy-specific saturated fatty acids have been inversely, while inflammation and oxidative stress have been positively related to the risk of cardiovascular disease (CVD). Both fatty acid metabolism and inflammation and oxidative stress may be influenced by adiposity. In the current cross-sectional analyses ...
Mailloux Ryan J - - 2011
Aluminum (Al) is a metal toxin that has been implicated in the etiology of a number of diseases including Alzheimer's, Parkinson's, dialysis encephalopathy, and osteomalacia. Al has been shown to exert its effects by disrupting lipid membrane fluidity, perturbing iron (Fe), magnesium, and calcium homeostasis, and causing oxidative stress. However, ...
Yan Yizhe - - 2011
A novel metal-free intramolecular oxidative decarboxylative coupling of primary α-amino acids with 2-aminobenzoketones under mild and neutral conditions was developed. Different quinazolines can be selectively obtained by various oxidants.
Purwaha Preeti - - 2011
Docosapentaenoic acid (DPA) is a unique fatty acid that exists in two isomeric forms (n-3 and n-6), which differ in their physiological behaviors. DPA can undergo free radical-mediated peroxidation via lipoxygenase (LOX). 15-LOX, one of the LOX isomers, has received much attention in cancer research because of its very different ...
Wang Yuan - - 2011
Heterogeneous photocatalytic decomposition of perfluoroocatanoic acid (PFOA) by TiO(2) under 254nm UV light was investigated. Adding oxalic acid as a hole-scavenger significantly accelerated PFOA decomposition under nitrogen atmosphere. Fluoride ion, formic acid and six shorter-chain perfluorinated carboxylic acids (PFCAs) bearing C(2)-C(7) were identified as intermediates. When using perchloric acid (HClO(4)) ...
Ding Ye - - 2011
A novel and facile DDQ-mediated dehydrogenation from natural rigid polycyclic acids or flexible alkyl acids to generate lactones is described. The formation of lactones proceeds by a radical ion mechanism, which has been established by DPPH˙-mediated chemical identification, ESR spectroscopy and an enol intermediate trapping.
Luan He-Mi - - 2011
Aqueous (ET1) and alcoholic (ET2) extracts from Mactra veneriformis were studied for their antioxidant potentials using various in vitro assays. The ET2 was fractioned into four parts according to the polarity of the extractive medium, viz. ET2-p (petroleum ether), ET2-e (ethyl acetate), ET2-n (n-butanol) and ET2-w (water). Among the four fractions, ...
Andreo Ursula - - 2011
VLDL is produced by the liver. Its major protein is apoB100. Docosahexaenoic acid (DHA), a dietary polyunsaturated fatty acid (PUFA), reduces VLDL levels and is used therapeutically for hypertriglyceridemia. In model systems, DHA lowers VLDL secretion by inducing presecretory apoB100 degradation, a process dependent on PUFA-derived lipid peroxides. We hypothesized ...
Huang Ke-Jing - - 2011
Graphene/p-aminobenzoic acid composite film modified glassy carbon electrode (Gr/p-ABA/GCE) was first employed for the sensitive determination of dopamine (DA). The electrochemical behavior of DA at the modified electrode was investigated by cyclic voltametry (CV), differential pulse voltametry (DPV) and amperometric curve. The oxidation peak currents of DA increased dramatically at ...
Gauthier Kathryn M KM Department of Pharmacology and Cardiovascular Center, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA. - - 2011
Cytochrome P-450 metabolites of arachidonic acid, the epoxyeicosatrienoic acids (EETs) and hydrogen peroxide (H(2)O(2)), are important signaling molecules in the kidney. In renal arteries, EETs cause vasodilation whereas H(2)O(2) causes vasoconstriction. To determine the physiological contribution of H(2)O(2), catalase is used to inactivate H(2)O(2). However, the consequence of catalase action ...
Liu Chaomin - - 2011
The range and scope of the oxidative oxazoline-oxazinone rearrangement-hydrogenation sequence (OOOH)-a short, direct asymmetric synthesis of α-amino acids from carboxylic acids-was explored. The highest yet reported diastereoselectivity for hydrogenation of the oxazinone CN bond (d.r.=>80:1) is disclosed and rationalized with the aid of ab initio molecular calculations.
Xu Qin - - 2011
Electrode with optical shapes is appreciated in microfluidics. In this article, we reported a flexible poly(dimethylsiloxane) (PDMS)-based gold electrode for ascorbic acid detection. Gold nanoparticles were chemically deposited on PDMS and the composite film was applied as working electrode. The electrode could undergo deformation and display good response performance without ...
Holla Vijaykumar R - - 2011
Although cancer cells have traditionally been thought to rely on the glycolytic pathway to generate ATP, recent studies suggest that cancer cells can shift to the fatty acid oxidation pathway as an alternative energy source. All of the factors that induce and regulate this adaptive shift in metabolism are not ...
Mikami Yoshinori - - 2011
Hydrogen sulfide (H2S) has recently been recognized as a signaling molecule as well as a cytoprotectant. We recently demonstrated that 3-mercaptopyruvate sulfurtransferase (3MST) produces H2S from 3-mercaptopyruvate (3MP).  Although a reducing substance is required for an intermediate persulfide at the active site of 3MST to release H2S, it has not ...
Ahmad Iqbal - - 2011
The kinetics of photolysis of ascorbic acid in cream formulations on UV irradiation has been studied using a specific spectrophotometric method with a reproducibility of ± 5%. The apparent first-order rate constants (k(obs)) for the photolysis of ascorbic acid in creams have been determined. The photoproducts formed in the cream ...
Zhang Xiaoyu - - 2011
NAD(P)H: quinone oxidoreductase1 (NQO1) is an important detoxification enzyme that can protect mammalian cells against toxic quinones and reduce the risk of tumorigenesis. In the present study, it was found that salvianolic acid B (SaB), lithospermic acid (LA) and rosmarinic acid (RA), three main hydrophilic constituents in Danshen, conjugated with ...
Mattijssen Frits - - 2011
Lipotoxicity describes the process of cellular dysfunction in response to lipid overload. In this issue of Cell Metabolism, Michel and colleagues (2011) provide evidence for a role of snoRNAs in palmitate-induced oxidative stress.
Mari Kannan M - - 2011
The anti lipid peroxidative and antioxidant effects of ellagic acid against isoproterenol-induced myocardial infarcted rats were reported previously. This study was designed to evaluate the protective effects of ellagic acid on the levels of cardiac troponin-T, lysosomal enzymes, and membrane bound ATPases along with the role of pro inflammatory cytokine. ...
Degirolamo Chiara C Laboratory of Lipid Metabolism and Cancer, Department of Translational Pharmacology, Consorzio Mario Negri Sud, Via Nazionale 8/A, 66030 Santa Maria Imbaro (Chieti), - - 2011
Colorectal cancer is the third most common malignancy worldwide and is often linked to obesity, a sedentary lifestyle, carbohydrate- and fat-rich diets and elevated fecal excretion of secondary bile acids. Accumulation of toxic bile acids triggers oxidative damage, mitochondrial dysfunction and tumor progression. Nuclear receptors are transcription factors crucially involved ...
Bradshaw Marc P - - 2011
Extensive reviews of research are available on the use of ascorbic acid, and its consequent degradation pathways, in physiological conditions or food matrices. However, very little information can be found for wine-related systems. This review highlights the relevant chemistry and reactivity of ascorbic acid with a focus on its behavior ...
Gorąca Anna - - 2011
α-Lipoic acid (LA; 5-(1,2-dithiolan-3-yl)pentanoic acid) was originally isolated from bovine liver by Reed et al. in 1951. LA was once considered a vitamin. Subsequently, it was found that LA is not a vitamin and is synthesized by plants and animals. LA is covalently bound to the ε-amino group of lysine ...
Abazi Sokol - - 2011
Radical alkylation of 2-(tert-butyl)-2-methyldioxolan-4-one, a chiral equivalent of glycolic acid, occurs with good to high diastereoselectivity that compares favorably with the corresponding enolate alkylation. The importance of the position of the transition state position, early or late, is highlighted.
Pandey A - - 2011
Coriandrum sativum (Linn.), a glabrous, aromatic, herbaceous annual plant, is well known for its use in jaundice. Essential oil, flavonoids, fatty acids, and sterols have been isolated from different parts of C. sativum. The plant has a very effective antioxidant profile showing 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity, lipoxygenase inhibition, phospholipid ...
Yang Dongxu - - 2011
A copper/DIPEA-catalyzed, aldehyde-induced intermolecular decarboxylative coupling reaction of natural alpha-amino acids and phosphites or secondary phosphine oxides was developed. In this process, a series of potentially useful ligands for organic syntheses and biologically important unnatural amino acid derivatives (tertiary amino phosphorus compounds) were obtained.
Mortimer Monika - - 2011
In the current study, the toxicity mechanism of nanosized CuO (nCuO) to the freshwater ciliated protozoa <i>Tetrahymena thermophila</i> was studied. Changes in fatty acid profile, lipid peroxidation metabolites and reactive oxygen species (ROS) were measured. Bulk CuO and CuSO<sub>4</sub> served as controls for size and solubility and 3,5-dichorophenol (3,5-DCP) as ...
Tian Hong-Lei - - 2011
Ansu apricots growing wild in north Xinjiang are recognised as being one of the major wild-plant resources in China. In order to improve the level of comprehensive utilisation and the number of cultivated apricot varieties, the chemical composition of ansu apricot oil was analysed by capillary GC-MS and elucidated based ...
Fu Guoxing - - 2011
D-Arginine dehydrogenase (DADH) catalyzes the flavin-dependent oxidative deamination of D-arginine and other D-amino acids to the corresponding imino acids. The 1.07 Å atomic resolution structure of DADH crystallized with D-leucine unexpectedly revealed a covalent flavin N(5) adduct, instead of the expected iminoleucine product in the active site. This acyl adduct ...
Masi Laureane Nunes - - 2011
The effects of stearic (saturated) or oleic (monounsaturated) acids and their combination with ω-3 and ω-6 polyunsaturated fatty acids (PUFA) on death of endothelial cells (ECV-304 cell line) were investigated. We examined: loss of plasma membrane integrity, DNA fragmentation, accumulation of neutral lipids (NL) and release of reactive oxygen species ...
Yang Jin - - 2011
The composition and in vitro antioxidant activities of the essential oil and methanol extract of the aerial parts of Viola tianshanica were evaluated in this research. GC-MS analysis of the essential oil resulted in the identification of 15 constituents, representing 89.67% of the oil. The major compounds detected in the essential ...
Huang Li-Nan - - 2011
Analysis of spatial and temporal variations in the microbial community in the abandoned tailings impoundment of a Pb-Zn mine revealed distinct microbial populations associated with the different oxidation stages of the tailings. Although Acidithiobacillus ferrooxidans and Leptospirillum spp. were consistently present in the acidic tailings, acidophilic archaea, mostly Ferroplasma acidiphilum, ...
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