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Nelson H M HM Department of Chemistry, University of California, Berkeley, California 94720, United - - 2015
Chiral anion phase-transfer of aryldiazonium cations was utilized to achieve highly enantioselective α-amination of carbonyl compounds. A broad scope of indanone- and benzosuberone-derived substrates was amenable to this strategy. Critical to obtaining high levels of enantioselectivity was the use of BINAM-derived phosphoric acids. The utility of this transformation was demonstrated ...
Tsai Der-Shiang DS 1 Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Pharmacy, China Medical University , Taichung, Taiwan, Republic of China - - 2014
Abstract In this study, we evaluated the analgesic and anti-inflammatory activities of a 70% ethanol extract from Rosa taiwanensis Nakai (RTEtOH). The analgesic effect was determined using acetic acid-induced writhing response and formalin test. The anti-inflammatory activity was evaluated by λ-carrageenan-induced paw edema in mice. The anti-inflammatory mechanism of RTEtOH ...
Kan Emrah E Department of Ophthalmology, Samsun Training and Research Hospital, Samsun, Turkey, - - 2014
The purpose of this study was to determine whether α-lipoic acid and fisetin have protective effects against cataract in a streptozotocin-induced experimental cataract model. Twenty-eight male BALB/C mice were made diabetic by the intraperitoneal administration of streptozotocin (200 mg/kg). Three weeks after induction of diabetes, mice were divided randomly into 4 ...
Chen Jianliang J Department of Otolaryngology, Jiangsu University Affiliated Yixing People's Hospital, Yixing, Jiangsu Province, 214200, China, - - 2014
Ferulic acid is a polyphenol that has antioxidant, anti-inflammatory and anticancer properties. The present study analyzed the antidepressant-like potential of ferulic acid using two well-validated mouse models of despair test, tail suspension and forced swim tests. The results suggested that ferulic acid treatment at doses of 10, 20, 40 and ...
Ancel Deborah D Universite de Bourgogne/AgroSupDijon, - - 2014
Implication of the long-chain fatty acid (LCFA) receptor GPR120, also termed free fatty acid receptor 4 (FFAR4), in the taste-guided preference for lipids is a matter of debate. To further unravel the role of GPR120 in the "taste of fat", the present study was conducted on GPR120-null mice and their ...
Cao Jun - - 2014
Four vegetable oils with typical fatty acid compositions were chosen to determine their indicators of lipid oxidation under the conditions of the accelerated oxidation. Good linear correlations were observed between the total nonpolar carbonyl amount and the total oxidation value (TOTOX, R2 =0.89-0.97), or peroxide value (POV, R2 = 0.92-0.97) ...
Kawata Kohei - - 2014
We previously reported RXR partial agonist CBt-PMN (1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)-1H-benzotriazole-5-carboxylic acid: 5, EC50 = 143 nM, Emax = 75%), which showed a potent glucose-lowering effect without causing serious adverse effects. However, it remains important to elucidate the structural requirements for RXR efficacy and the glucose-lowering effect, because RXR-permissive heterodimers such as PPAR/RXR ...
Mengistie Desalegn Alemu - - 2014
For inorganic thermoelectric materials, Seebeck coefficient and electrical conductivity are interdependent and hence optimization of thermoelectric performance challenging. In this work we show that thermoelectric performance of PEDOT:PSS can be enhanced by greatly improving its electrical conductivity in contrary to inorganic thermoelectric materials. Free-standing flexible and smooth PEDOT:PSS bulky papers ...
Sannino Filomena - - 2014
The oxidative degradation of 2-methyl-4-chlorophenoxyacetic acid (MCPA), 4-(4-chloro-2-methylphenoxy)butanoic acid (MCPB), 4-chlorophenoxyacetic acid (4-CPA) and 2,4-dichlorophenoxyacetic acid (2,4 D) by ZrO2-acetylacetonate hybrid catalyst (HSGZ) without light irradiation was assessed. The thermal stability of the catalyst was investigated by thermogravimetry, differential thermal analysis, and Fourier transform infrared spectroscopy. For each herbicide a ...
Guetg Adriano A Institute of Physiology and Zurich Center of Integrative Human Physiology, University of Zurich, - - 2014
Amino acid uniporter Lat4 (Slc43a2) mediates facilitated diffusion of branched-chain amino acids, methionine and phenylalanine, but its physiological role and subcellular localization are not known. We report here that Slc43a2 knock-out mice were born at expected Mendelian frequency but displayed an ∼10% intrauterine growth retardation and low amniotic fluid amino ...
Neelakantan Harshini H aDepartment of Pharmaceutical Sciences, School of Pharmacy bCenter for Substance Abuse Research, School of Medicine, Temple University, Philadelphia, Pennsylvania, - - 2014
Cannabinoid and opioid agonists can display overlapping behavioral effects and the combination of these agonists is known to produce enhanced antinociception in several rodent models of acute and chronic pain. The present study investigated the antinociceptive effects of the nonpsychoactive cannabinoid, cannabidiol (CBD) and the µ-opioid agonist morphine, both alone ...
Tuntiyasawasdikul Sarunya S Center for Research and Development of Herbal Health Products, Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen 40002, - - 2014
The aim of this study was to design and develop a suitable monolithic drug-in-adhesive type patch of methoxyflavones from Kaempferia parviflora (K. parviflora) using acrylic polymer Durotak(®) 87-2852. The absence of interaction between components in K. parviflora extract and the adhesive polymer was confirmed by attenuated total reflectance-Fourier transform infrared ...
Wiest Elani F EF Department of Pharmaceutical Sciences, College of Pharmacy, University of New Mexico, Albuquerque, NM, - - 2014
Impaired flow-mediated dilation (FMD) occurs prior to clinical disease in young cigarette smokers. We investigated two potential biomarkers of FMD: serum aryl hydrocarbon receptor (AHR) activity and RBC omega-3 polyunsaturated fatty acids in healthy young Hispanic cigarette smokers. We recruited never (n=16) and current (n=16) Hispanic smokers (32±7 years old), ...
Gehmlich Katja K Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, - - 2014
Energy depletion has been highlighted as an important contributor to the pathology of hypertrophic cardiomyopathy (HCM), a common inherited cardiac disease. Pharmacological reversal of energy depletion appears an attractive approach and the use of perhexiline has been proposed as it is thought to shift myocardial metabolism from fatty acid to ...
Matsuda Takanori T Department of Applied Chemistry, Tokyo University of Science, 1-3 Kagurazaka, Shinjuku-ku, Tokyo 162-8601, Japan. - - 2014
The rhodium(i)-catalysed arylative annulation of 1,4-enynes with arylboronic acids was investigated. The reaction was found to proceed via an addition-1,4-rhodium migration-addition sequence, affording the corresponding 1,1-disubstituted 3-(arylmethylene)indanes.
Dinler Burcu Seckin BS Sinop University Faculty of Arts and Sciences, Biology Sinop - - 2014
In the present study, the effect of ascorbic acid (5 mM) on some physiological parameters and three hormones (auxin, abscisic acid, salicylic acid) was determined under heat stress (40 °C) in maize tolerant cv. (MAY 69) and sensitive cv. SHEMAL (SH) at 0 h, 4 h and 8 h. Heat ...
Ivanovic Nevena N Department of Bromatology, Faculty of Pharmacy, University of Belgrade , Belgrade , Serbia - - 2014
Abstract Recent reports suggest that the metabolic activity of the enteric microbiota may influence the fatty acid composition of the host tissue. There are many studies dealing with the influence of lactobacilli on various pathological conditions, and some of the effects are strain-specific. This study was designed to test the ...
Romih Tea T Department of Biology, Biotechnical Faculty, University of Ljubljana, Večna pot 111, 1000 Ljubljana, Slovenia. Electronic address: - - 2014
The aim of this study was to determine whether citric acid adsorbed onto cobalt ferrite (CoFe2O4) nanoparticles (NPs) influences the bioavailability of their constituents Co and Fe. Dissolution of Co and Fe was assessed by two measures: (i) in aqueous suspension using chemical analysis, prior to application onto the food ...
Gao Hui H Department of Pharmacology and Toxicology, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, PR China; Department of Pharmacology, School of Medicine, Jishou University, Jishou, PR - - 2014
Adipose triglyceride lipase (ATGL), the rate-limiting enzyme of triglyceride (TG) hydrolysis, plays an important role in TG metabolism. ATGL knockout mice suffer from TG accumulation and die from heart failure. However, the mechanisms underlying cardiac hypertrophy caused by ATGL dysfunction remain unknown. In this study, we found that ATGL expression ...
Szymczak Grażyna G a Botanical Garden of Maria Curie-Skłodowska University in Lublin , Sławinkowska 3, 20-810 Lublin , - - 2014
Actaea racemosa L. is used as a component of drugs or dietary supplements to alleviate the menopause symptoms. Its biological activity is associated with the presence of phenolic compounds. In our work, the analysis of isoflavones and phenolic acids - caffeic acid (CA), ferulic acid and isoferulic acid (iFA) - ...
Alexou Maria M Laboratory of Forest Protection, School of Forestry and Natural Environment, Aristotle University of Thessaloniki, P.O. Box 228, 54124 Thessaloniki, Greece - - 2014
Climatic change causes gradual deforestation, partly through forest fires. However, fire has not been seen as an oxidative stressor on surviving forest trees. In addition, discrimination of stress-induced responses from acclimation steps cannot be examined under prolonged stress. Thus, four young Brutian pine (Pinus brutia Ten.) trees, a fire-related species, ...
Huang Chao C Key Laboratory of Renewable Energy, Chinese Academy of Sciences, Guangzhou, 510640, People's Republic of - - 2014
In this study, corncob acid hydrolysate was used as a substrate for bacterial cellulose (BC) production by Gluconacetobacter xylinus. After 2 weeks' static fermentation, a BC yield of 4 g/L could be obtained. Both effects of medium composition and fermentation condition on the BC production were evaluated. Most extra substrates (carbon and ...
Karita Shingo - - 2014
Rapid and simple acid-base titration was accomplished using a novel microfluidic paper-based analytical device (μPAD). The μPAD was fabricated by wax printing and consisted of ten reservoirs for reaction and detection. The reaction reservoirs contained various amounts of a primary standard substance, potassium hydrogen phthalate (KHPth), whereas a constant amount ...
Castro Micheli R MR Laboratório de Síntese Orgânica Limpa, CCQFA, Universidade Federal de Pelotas , Pelotas-RS , Brazil - - 2014
Abstract Context: Psidium cattleianum Sabine (Myrtacea) is rich in vitamin C and phenolic compounds, including epicatechin and gallic acid as the main components. Objective: To evaluate the antifungal and antioxidant capacity in vitro of the essential oil of araçá (EOA). The acute toxicity of the EOA also was evaluated in ...
Huang Zhen-Yuan ZY a College of Pharmacy and Chemistry, Institute of Materia Medica, Dali University , Dali 671000 , P.R. - - 2014
Two new labdane diterpenoids, s-trans-8(17),12E,14-labdatrien-20-oic acid (1), s-trans-12E,14-labdadien-20,8β-olide (2), along with 10 known compounds, hinokiol (3), ursonic acid (4), 2α,3α-dihydroxyolean-12-en-28-oic acid (5), 2α,3β,23-trihydroxyolean-12-en-28-oic acid (6), ethyl 3-(3,4-dihydroxyphenyl)lactate (7), ethyl rosmarinate (8), (Z,E)-2-(3,4-dihydroxyphenyl)ethenyl caffeic ester (9), tridecanoic acid (10), β-sitosterol (11) and daucosterol (12), were isolated from the 70% acetone extract ...
Dogi Cecilia A CA a Departamento de Microbiología e Inmunología , Universidad Nacional de Río Cuarto , Río Cuarto , Córdoba , - - 2014
Laboratory-scale silos were prepared to evaluate the efficacy of two different lactic acid bacteria (LAB) on the fermentation quality and mycobiota of corn silage. Their influence on Aspergillus species variability by using the q-PCR technique was studied. Silage inoculated with Lactobacillus rhamnosus RC007 or L. plantarum RC009 were compared to ...
Lamaziere Antonin A Laboratory of Mass Spectrometry, ERL INSERM U 1057/UMR 7203, Université Pierre et Marie Curie, Paris, - - 2014
Long-chain n-3 (or omega 3) fatty acids, namely docosahexaenoic acid (DHA, 22:6n-3) and eicosapentaenoic acid (EPA, 20:5n-3) have been attributed cardioprotective properties. In this study, we evaluated the incorporation of DHA into cardiomyocytes and the shift in the omega 3/omega 6 ratio after supplementation of primary cardiomyocyte culture. Results are ...
Liu Hao H Department of Neurosurgery, The Third Xiangya Hospital of Central South University, Changsha, 410013, Hunan, People's Republic of - - 2014
Trans-caryophyllene (TC), a component of essential oil found in many flowering plants, has shown its neuroprotective effects in various neurological disorders. However, the effects of TC on epilepsy haven't been reported before. In this study, we investigated the effect of TC on kainic acid-induced seizure activity caused by oxidative stress ...
Hashimoto Michio M Department of Environmental Physiology, Shimane University Faculty of Medicine, Izumo, Shimane 693-8501, Japan. Electronic address: - - 2014
We investigated whether a highly purified eicosapentaenoic acid (EPA) and a concentrated n-3 fatty acid formulation (prescription TAK-085) containing EPA and docosahexaenoic acid (DHA) ethyl ester improve the learning ability of aged rats and whether this specific outcome has any relation with the brain levels of EPA-derived eicosanoids and DHA-derived ...
Sun Diankui D Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences , Changchun 130022, People's Republic of - - 2014
The acid-sensitive PEGylated doxorubicin (DOX) with exact chemical structure was designed and prepared as a potential tumor intracellular microenvironment-responsive drug delivery system. First, the insensitive succinic anhydride-functionalized DOX (i.e., SAD) and acid-sensitive cis-aconitic anhydride-modified DOX (i.e., CAD) were synthesized through the ring-opening reaction. Subsequently, the insensitive and acid-sensitive PEGylated DOX ...
Wu Hui-Yuan HY St. Jude Children's Research Hospital, United - - 2014
Nna1 (a.k.a. CCP1) defines a subfamily of M14 metallo-carboxypeptidases (CCP1-6) and is mutated in Purkinje cell degeneration (pcd) mice. Nna1, CCP4 and CCP6 are involved in the posttranslational process of polyglutamylation, where they catalyze the removal of polyglutamate side-chains. However it is unknown whether these three CCPs share identical enzymatic ...
Xin Junliang J Research Center for Environmental Pollution Control Technology, Department of Safety and Environmental Engineering, Hunan Institute of Technology, Hengyang, 421002, - - 2014
Cultivars of hot pepper (Capsicum annuum L.) have different abilities to accumulate Cd in their fruits. Previously, we suggested that low-Cd cultivars take up more Cd, but can better prevent the Cd translocation from roots to aerial parts. However, the mechanisms involved in those processes are still unclear. In this ...
Ulset Ann-Sissel T AS NOBIPOL, Department of Biotechnology, Norwegian University of Science and Technology (NTNU) , N-7491 Trondheim, - - 2014
Alginate-based biomaterials and medical devices are commonly subjected to γ-irradiation as a means of sterilization, either in the dry state or the gel (hydrated) state. In this process the alginate chains degrade randomly in a dose-dependent manner, altering alginates' material properties. The addition of free radical scavenging amino acids such ...
Gu Shenghua S State Key Laboratory of Natural Medicines, Key Laboratory of Drug Metabolism and Pharmacokinetics, Jiangsu Key laboratory of drug design and optimization, China Pharmaceutical University, Nanjing 210009, China. - - 2014
Clinical and animal studies demonstrated that orally administered berberine had a distinct lipid-lowering effect. However, pharmacokinetic studies showed that berberine was poorly absorbed into the body so the levels of berberine in the blood and target tissues were far below the effective concentrations revealed. To probe the underlying mechanism, the ...
Münchow Eliseu Aldrighi EA Graduate Program in Dentistry, School of Dentistry, Federal University of Pelotas, Pelotas, RS, Brazil. Electronic address: - - 2014
The aim of this study was to synthesize an alternative acidic monomer (polypropylene glycol phosphate methacrylate - Poly-P) to constitute experimental two-step self-etch adhesive systems and also to evaluate its influence on the pH and microshear bond strength (μSBS) to enamel. Primers containing Poly-P (10, 15, 30 or 50wt.%), HEMA, ...
Chen Longjian L China Agricultural University (East campus), 17 Qing-Hua-Dong-Lu, Hai-Dian District, Beijing 100083, PR - - 2014
Kinetic experiments on the dilute sulfuric acid pretreatment of corn stover were performed. A high xylan removal and a low inhibitor concentration were achieved by acid pretreatment. A novel diffusion-hydrolysis coupled kinetic model was proposed. The contribution to the xylose yield was analyzed by the kinetic model. Compared with the ...
Poudel Pramod P Laboratory of Soil Microbiology, Division of Systems Bioengineering, Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School of Bioresources and Bioenvironmental Sciences, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka, 812-8581, - - 2014
A newly isolated Bacillus sp. MC-07 showed 99.2 % 16S rRNA gene sequence similarity with the Bacillus thermoamylovorans LMG 18084(T). It demonstrated optimum and maximum growth temperatures of 50 and 62 °C, respectively. The ability of MC-07 to produce optically pure L-lactic acid via direct fermentation of starch without enzymatic hydrolysis was investigated ...
Rezg Raja R Laboratoire de Physiologie des Agressions, Département de Biologie, Faculté des Sciences de Tunis, Université El Manar, Tunis, - - 2014
Exposure to pesticides is suspected to cause human health problems. Our study aimed to evaluate preventive effects of caffeic acid (3,4-dihydroxycinnamic acid) in the hypothalamus against malathion-induced neuropeptides gene expression alterations. Malathion at 100 mg/kg was administered intragastrically to rats alone or in combination with caffeic acid at 100 mg/kg during 4 weeks. ...
Makunina Maria P MP V.V. Voevodsky Institute of Chemical Kinetics and Combustion, Institutskaya str. 3, 630090 Novosibirsk, Russian - - 2014
Laser flash (355nm) and stationary (365nm) photolysis were used to study the mechanisms of propranolol photolysis in the presence of fulvic acid in aqueous solutions. The FA-assisted photodegradation of propranolol was observed using UV-A irradiation (where propranolol is stable). Direct evidence indicated that the photodegradation resulted from the static quenching ...
Collins Gillian - - 2014
Many applications of germanium (Ge) are underpinned by effective oxide removal and surface passivation. This important surface treatment step often requires H-X (X = Cl, Br, I), or HF etchants. Here, we show that aqueous citric acid solutions are effective for the removal of GeOx. The stability of citric acid ...
Nurlinawati Laboratory of Food Microbiology and Leuven Food Science and Nutrition Research Center (LFoRCe), Department of Microbial and Molecular Systems (M(2)S), Faculty of Bioscience Engineering, KU Leuven, Kasteelpark Arenberg 22, B-3001 Leuven, Belgium. Electronic address: - - 2014
A mutant with a transposon insertion just upstream of the lysophosphatidic acid acyltansferase gene plsC was isolated in a screen for mutants affected in growth at low temperature of the psychrotroph Serratia plymuthica RVH1. This mutant had lost its ability to grow at 4 °C and was severely affected in growth ...
Miao Wangen W School of Chemistry and Chemical Engineering, Institute of Physical Chemistry, Lingnan Normal University, Development Centre for New Materials Engineering & Technology in Universities of Guangdong, Zhanjiang, 524048 (P. R. China). - - 2014
A new class of L-glutamic gelators, LG12 (CH2 )n COOH, containing different lengths of methylene spacer were synthesized. It was found that the gelation ability of these compounds themselves was very weak. However, when another compound, p-xylylenediamine (XEA), was introduced, the gelation ability was improved greatly. In particular, LG12 (CH2 ...
Zhang Hongdan - - 2014
Acetic acid ethanol-based organosolv pretreatment of sugarcane bagasse were performed to enhance enzymatic hydrolysis. The effect of different parameters (including temperature, reaction time, solvent concentration, and acid catalyst dose) on pretreatment prehydrolyzate and subsequent enzymatic digestibility were determined. During the pretreatment process, 11.83 g xylose based on 100 g raw ...
Amiri Mandana M Department of Chemistry, University of Mohaghegh Ardabili, Ardabil, Iran. Electronic address: - - 2015
In this approach, electro-oxidation of a mixture of uric acid and ascorbic acid at the surface of tosyl surface carbon nanoparticles/glassy carbon electrode has been performed. The electro-oxidation of these compounds at bare electrode is sluggish and there is no suitable peak separation between them. However, using functionalized carbon nanoparticles, ...
Musselwhite Nathan N Department of Chemistry, University of California, Berkeley , Berkeley, California 94720, United - - 2014
When pure mesoporous silica (MCF-17) was modified with aluminum (Al modified MCF-17), Lewis acid sites were created, but this material was inactive for the catalytic conversion (reforming) of n-hexane to isomers. When colloidally synthesized platinum nanoparticles were loaded onto traditional MCF-17, the catalyst showed very low activity toward isomer production. ...
Meng Zhao-Qing ZQ State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, P. R. China , Jiangsu Kanion Pharmaceutical Co. Ltd., Lianyungang 222001, P. R. - - 2014
Gout is a metabolic disorder associated with hyperuricemia resulting in the deposition of monosodium urate (MSU) crystals in joints and tissues. Lowering serum uric acid (Sur) levels and anti-inflammation are highly essential in treating gout. Chlorogenic acid (CA), as one of the most abundant polyphenols in the Chinese medicines, has ...
Ghosh Tanushree T Biosensor Laboratory, Department of Polymer Science and Technology, University of Calcutta, 92 A.P.C. Road, Kolkata 700 009, - - 2014
A new uric acid biosensor was constructed using ferrocene (Fc) induced electro-activated uricase (UOx) deposited within Nafion (Naf) on glassy carbon electrode (GCE). Electro-activation of UOx was successfully achieved by cyclic voltammetry through the electrostatic interaction of Fc with Trp residues within the hydrophobic pockets in UOx. The Naf/UOx/Fc composite ...
Bogdanovic Elena E Division of Plastic Surgery, Division of General Surgery, Department of Surgery, Department of Immunology, University of Toronto, Ross Tilley Burn Centre, Sunnybrook Health Sciences Centre, Sunnybrook Research Institute, Toronto, ON, - - 2014
The endoplasmic reticulum (ER) is an organelle important for protein synthesis and folding, lipid synthesis and Ca(2+) homoeostasis. Consequently, ER stress or dysfunction affects numerous cellular processes and has been implicated as a contributing factor in several pathophysiological conditions. Tunicamycin induces ER stress in various cell types in vitro as ...
Zhang Di D Faculty of Environmental Science & Engineering, Kunming University of Science & Technology, Kunming 650500, China; Stockbridge School of Agriculture, University of Massachusetts, Amherst, MA 01003, - - 2014
Dissolved humic acid (disHA) is effective for suspending carbon nanotubes (CNTs), but the suspending mechanism is still unclear. This study used bleached and hydrolyzed humic acids as suspending agents to investigate effects of chemical structures on CNTs suspension. The adsorption of aromatic moieties-enriched disHA to CNTs was lower than aliphatic ...
Rohilla Raman R Department of Pharmaceutics - - 2014
Abstract Glycyrrhetinic acid-modified chitosan (mGA-suc-CTS) is used as liver-targeted carrier for drug delivery. In this study, nanoparticles were prepared by ionic gelation process, and glycyrrhetinic acid act as the targeting ligand. The structure of the product was confirmed by IR and NMR techniques. The main aim of this study was ...
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