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Vlassopoulos A A Human Nutrition, School of Medicine, College of Medical, Veterinary & Life Sciences, University of Glasgow, Glasgow, G3 8SJ, UK. - - 2014
Background: while antiglycative capacity has been attributed to (poly)phenols, the exact mechanism of action remains unclear. Studies so far are often relying on supra-physiological concentrations and use of non-bioavailable compounds. Methods: to inform the design of a physiologically relevant in vitro study, we carried out a systematic literature review of ...
Ferdinandusse Sacha S Laboratory Genetic Metabolic Diseases, Departments of Pediatrics and Clinical Chemistry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands - - 2014
ABCD3 is one of three ATP-binding cassette (ABC) transporters present in the peroxisomal membrane catalyzing ATP-dependent transport of substrates for metabolic pathways localized in peroxisomes. So far the precise function of ABCD3 is not known. Here we report the identification of the first patient with a defect of ABCD3. The ...
Hua Xiangdong X Hepatobiliary and Pancreatic Surgery, Liaoning Cancer Hospital and Institute, Shenyang, 110042, - - 2014
Gambogic acid and gambogenic acid are two major bioactive components of Garcinia hanburyi, and play a pivotal role in biologic activity. In this study, a specific and sensitive liquid chromatography-tandem mass spectrometry was developed and validated for simultaneous determination of gambogic acid and gambogenic acid in rat plasma. Chromatographic separation ...
Jiang Zhi-Bo ZB a State Key Laboratory of Bioactive Substance and Function of Natural Medicines , Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050 , - - 2014
Seven new aromatic acid derivatives (1-7), together with five known analogs, were isolated from the lateral roots of Aconitum carmichaelii. Structures of the new compounds were determined by spectroscopic and chemical methods as 4-methyl ( - )-(R)-hydroxyeucomate (1), 4-butyl ( - )-(R)-hydroxyeucomate (2), 4-butyl-1-methyl (+)-(R)-2-O-(4'-hydroxy-3'-methoxybenzoyl)malate (3), 1-butyl-4-methyl (+)-(R)-2-O-(4'-hydroxy-3'-methoxybenzoyl)malate (4), dimethyl (+)-(R)-2-O-(4'-hydroxy-3'-methoxybenzoyl)malate (5), dimethyl (+)-(R)-2-O-(4'-hydroxybenzoyl)malate ...
Kanĸár R R Department of Biological and Biochemical Sciences, Faculty of Chemical Technology, University of Pardubice, Pardubice, Czech Republic. - - 2014
Uric acid is the final product of human purine metabolism. It was pointed out that this compound acts as an antioxidant and is able to react with reactive oxygen species forming allantoin. Therefore, the measurement of allantoin levels may be used for the determination of oxidative stress in humans. The ...
Qamar Wajhul W Central Laboratory, Research Center, College of pharmacy, King Saud University, Riyadh, Saudi - - 2014
ABSTRACT Objective: Rat bronchoalveolar lavage fluid (BALF) metabolome can be used to obtain valuable, precise, and accurate information about underlying lung conditions in an experiment. The present study focuses on the evaluation of the lung epithelium metabolome in a rat model using techniques including bronchoalveolar lavage, gas chromatography-mass spectroscopy (GC-MS), ...
Nohara Kenta K Department of Bioengineering, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259 Nagatsuta, Midori-ku, Yokohama - - 2014
The present study investigated simultaneous oxidation of pyruvate and amino acids during H2-evolving growth of hyperthermophilic archaeon Thermococcus kodakarensis. The comparison of mass balance between a cytosolic hydrogenase (HYH)-deficient strain (ΔhyhBGSL) and the parent strain indicated that NADPH generated via H2 uptake by HYH was consumed by reductive amination of ...
Sun Hongnan - - 2014
In this study, effects of boiling, steaming, microwaving, baking and frying on proximate composition, total and individual polyphenol content and antioxidant activity of sweet potato leaves were investigated. An increase of 9.44% in total polyphenol content was observed after steaming, whereas a decrease of 30.51%, 25.70% and 15.73% was noticed ...
Avila-Cisneros Nayeli N Universidad Autónoma Metropolitana-Unidad Iztapalapa, Av. San Rafael Atlixco 186, Col. Vicentina, Iztapalapa, Mexico, 09340, D.F., - - 2014
A naturally immobilized biocatalyst with lipase activity was produced by Thermomyces lanuginosus on solid-state fermentation with perlite as inert support. Maxima lipase activities (22 and 120 U/g of dry matter, using p-nitrophenyl octanoate and trioctanoine, respectively, as substrates) were obtained after 72 h of solid culture, remaining nearly constant up to 120 h. ...
Tannour-Louet Mounia M Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX - - 2014
Disturbances in amino acid metabolism are increasingly recognized as being associated with, and serving as prognostic markers for, chronic human diseases such as cancer or type 2 diabetes. In the current study, a quantitative metabolomics profiling strategy revealed global impairment in amino acid metabolism in mice deleted for the transcriptional ...
Halicka J J Department of Pathophysiology, Comenius University in Bratislava, Jessenius Faculty of Medicine in Martin, Bratislava, - - 2014
Transient lower esophageal sphincter relaxation (TLESR) is the major mechanism of gastroesophageal reflux (GER) but the regulation of TLESR by stimuli in the esophagus is incompletely understood. If stimuli in the esophagus can influence TLESR, then such regulation may perpetuate or limit GER. We addressed the hypothesis that acid in ...
Chauhan Nidhi N Department of Biochemistry, M. D. University, Rohtak, 124001, Haryana, - - 2014
A method is described for preparation of uricase nanoparticles (100 nm in size) and their direct immobilization onto the Au electrode. The enzyme electrode along with Ag/AgCl as reference and Pt as auxiliary electrode were connected through potentiostat/galvanostat to construct an amperometric uric acid biosensor. The enzyme electrode was characterized by ...
Kurahashi Toshihiro T Department of Biochemistry and Molecular Biology, Yamagata University School of Medicine, Yamagata, - - 2014
Aldehyde reductase (AKR1A), a member of the aldo-keto reductase superfamily, suppresses diabetic complications via a reduction in metabolic intermediates; it also plays a role in ascorbic acid biosynthesis in mice. Because primates cannot synthesize ascorbic acid, a principle role of AKR1A appears to be the reductive detoxification of aldehydes. In ...
Schmeda-Hirschmann Guillermo G Laboratorio de Química de Productos Naturales, Instituto de Química de Recursos Naturales, Universidad de Talca, Casilla 747, 3460000 Talca, Chile. Electronic address: - - 2014
animal oils and fats from the fishes Electrophorus electricus and Potamotrygon motoro, the reptiles Boa constrictor, Chelonoidis denticulata (Geochelone denticulata) and Melanosuchus niger and the riverine dolphin Inia geoffrensis are used as anti-inflammatory agents in the Peruvian Amazon. The aim of the study was to assess the topic anti-inflammatory effect ...
Chen Guan-Yuan GY School of Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan; The Metabolomics Core Laboratory, Center of Genomic Medicine, National Taiwan University, Taipei, - - 2014
As fatty acids play an important role in biological regulation, the profiling of fatty acid expression has been used to discover various disease markers and to understand disease mechanisms. This study developed an effective and accurate comparative fatty acid analysis method using differential labeling to speed the metabolic profiling of ...
Barberis Antonio A Institute of Sciences of Food Production (ISPA), National Research Council (CNR), Traversa La Crucca, 3 Regione Baldinca, 07100 Li Punti, Sassari, Italy. Electronic address: - - 2014
Four fullerenes- or nanotubes-modified graphite sensor-biosensor systems (SBs), coupled with a dual-channel telemetric device, based on an ascorbate oxidase (AOx) biosensor, were developed for on line simultaneous amperometric detection of ascorbic acid (AA) and antioxidant capacity in blueberry, kiwi and orange juice. Fullerene C60 (FC60), fullerene C70 (FC70), single-walled carbon ...
Wu Hongqin H State Key Laboratory of Microbial Metabolism and School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China; Biomass Energy Research Center, Shanghai Jiao Tong University, Shanghai 200240, - - 2014
Biodiesel quality associated with biochemical components of Chlorella pyrenoidosa and Scenedesmus obliquus under different nitrate levels were investigated. The highest lipid contents of 54.5% for C. pyrenoidosa and 47.7% for S. obliquus were obtained in nitrate absence. Carbohydrate peaked at 0.3gL(-1) with values of 40.7% for C. pyrenoidosa and 42.5% ...
Itoh Kazue K Faculty of Nutritional Sciences, Nakamura Gakuen University, Fukuoka, Japan. Electronic address: - - 2014
Insulin resistance is central to the etiology of the metabolic syndrome cluster of diseases. Evidence suggests that a high-fat diet is associated with insulin resistance, which may be modulated by dietary fatty acid composition. We hypothesized that high saturated fatty acid intake increases insulin and gastric inhibitory polypeptide (GIP) secretion. ...
Gómez J J Department of Chemical Engineering, Food Technology, Faculty of Sciences, Campus Río San Pedro, PB 40, Puerto Real, University of Cadiz 11510, Spain. Electronic address: - - 2015
Winemaking of musts acidified with up to 3g/L of gypsum (CaSO4 2H2O) and tartaric acid, both individually and in combination, as well as a chemical modeling have been carried out to study the behaviour of these compounds as acidifiers. Prior to fermentation gypsum and tartaric acid reduce the pH by ...
Kljak Kristina K Department of Animal Nutrition, Faculty of Agriculture, University of Zagreb, Svetošimunska cesta 25, 10 000 Zagreb, Croatia. Electronic address: - - 2015
Carotenoids, which occur naturally in corn grains, have been associated with reduced risk of degenerative diseases. The aim of this research was to measure the carotenoid content of hexane extracts of six commercial high-yield corn hybrids and determine the relationship between carotenoid content and antioxidant activity. Levels of lutein, zeaxanthin, ...
Ohminami Hirokazu H Department of Clinical Nutrition, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto, Tokushima 770-8503, - - 2014
A dietary combination of sucrose and linoleic acid strongly contributes to the development of metabolic disorders in Zucker fatty rats. However, the underlying mechanisms of the metabolic disorders are poorly understood. We hypothesized that the metabolic disorders were triggered at a stage earlier than the 8 weeks we had previously ...
Chen Wenting W College of Food Science and Technology, Huazhong Agricultural University, Wuhan, Hubei 430070, - - 2015
The objective of this study was to evaluate the effects of charge-carrying amino acids (lysine (Lys), arginine (Arg), aspartic acid (Asp) and glutamic acid (Glu)) on the gelatinization and retrogradation properties of potato starch. Acidic amino acids (Asp and Glu) showed a decreasing trend in swelling power and granule size ...
Al-Bachir Mahfouz M Radiation Technology Dep., Atomic Energy Commission of Syria, P.O. Box: 6091, Damascus, Syria. Electronic address: - - 2015
The present study evaluated the quality of pistachio oil, as a function of irradiation, to determine the dose level causing undesirable changes to pistachio oil. Physicochemical fatty acid composition, acidity value, peroxide value, iodine value specification number, thiobarbituric acid (TBA) value and colour of pistachio oil extracted from samples treated ...
Aoki Natsumi N Laboratory of Physiology and Pharmacology, School of Advanced Science and Engineering, Waseda University, Tokyo 162-8480, - - 2014
Food deprivation (FD) induces hepatic steatosis in both rodents and humans. Although body composition, age, and sex influence hepatic triglyceride (TG) levels after FD, whether feeding patterns affect FD-induced liver TG increases is unknown. We hypothesized that restricted feeding (RF) of 1 meal per day during the active or inactive ...
Braverman Alexis A Feinberg School of Medicine of Northwestern University, Chicago, - - 2014
The use of circulating cell-free nucleic acid for prenatal aneuploidy screening has been rapidly accepted by patients and clinicians. We sought to compare decisions after a positive sequential screen and circulating cell-free nucleic acid assay. We reviewed results from sequential screening and circulating cell-free nucleic acid analyses in this retrospective ...
de Vries Paul S PS Department of Epidemiology, Erasmus Medical Center, the Netherlands; NUTRIM School for Nutrition, Toxicology and Metabolism, Departments of Complex Genetics, Cluster of Genetics and Cell Biology, Maastricht University, the - - 2014
Prenatal polyunsaturated fatty acid (PUFA) concentrations may be involved in the prenatal programming of adiposity. In this study we therefore explored the association between maternal PUFA concentrations, measured up to four times during pregnancy, and offspring adiposity at age 7 in 234 mother-child pairs of the Maastricht Essential Fatty Acid ...
Kwak Ho-Seok HS Department of Laboratory Medicine, Cheil General Hospital and Women's Healthcare Center, Kwandong University School of Medicine, Seoul, Republic of - - 2014
Little is known on how the dose and timing of exposure co-influence the cumulative concentration of fatty acids ethyl esters (FAEEs) in meconium. The objective of the study was to assess the cumulative concentration of FAEEs in meconium as a biomarker of light, moderate or heavy prenatal alcohol exposure occurring ...
Choi Anna L AL Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA. Electronic address: - - 2014
Methylmercury, a worldwide contaminant of fish and seafood, can cause adverse effects on the developing nervous system. However, long-chain n-3 polyunsaturated fatty acids in seafood provide beneficial effects on brain development. Negative confounding will likely result in underestimation of both mercury toxicity and nutrient benefits unless mutual adjustment is included ...
Strickland Alan D AD 101 Waterlily, Lake Jackson, TX 77566, United States. Electronic address: - - 2014
This hypothesis states that cerebral palsy (CP), autism spectrum disorder (ASD), and attention-deficit/hyperactivity disorder (ADHD) are all caused by an exaggerated central nervous system inflammatory response to a prenatal insult. This prenatal insult may be one or more episodes of ischemia-reperfusion, an infectious disease of the mother or the fetus, ...
Kim Min Woo MW Department of Obstetrics and Gynecology, Korea University College of Medicine, Seoul, South - - 2014
Although there is accumulating evidence regarding the additional protective effect of folic acid against adverse pregnancy outcomes other than neural tube defects, these effects have not been elucidated in detail. We evaluated whether folic acid supplementation is associated with favorable maternal and fetal outcomes. This was a secondary analysis of ...
Ganjali Dashti Marjan M School of Biosciences and Biotechnology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600 Bangi, Selangor, Malaysia ; Enteric Diseases Research Cluster, Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia (USM), 11800 Penang, - - 2014
The biosynthesis of biomedical products including lipid and gamma-linolenic acid (GLA) by Cunninghamella bainieri 2A1 was studied in repeated batch fermentation. Three key process variables, namely, glucose concentration, ammonium tartrate concentration, and harvesting time, were optimized using response surface methodology. Repeated batch fermentation was carried out by the cultivation of ...
Libiaková Michaela M Department of Plant Physiology, Faculty of Natural Sciences, Comenius University in Bratislava, Bratislava, - - 2014
The trap of the carnivorous plant Venus flytrap (Dionaea muscipula) catches prey by very rapid closure of its modified leaves. After the rapid closure secures the prey, repeated mechanical stimulation of trigger hairs by struggling prey and the generation of action potentials (APs) result in secretion of digestive fluid. Once ...
Martin Gregory J O GJ Department of Chemical and Biomolecular Engineering, The University of Melbourne, Parkville, Victoria, - - 2014
Many species of microalgae produce greatly enhanced amounts of triacylglycerides (TAGs), the key product for biodiesel production, in response to specific environmental stresses. Improvement of TAG production by microalgae through optimization of growth regimes is of great interest. This relies on understanding microalgal lipid metabolism in relation to stress response ...
Day P E L - - 2013
Placental glutamine synthesis has been demonstrated in animals and is thought to increase the availability of this metabolically important amino acid to the fetus. Glutamine is of fundamental importance for cellular replication, cellular function and inter-organ nitrogen transfer. The objective of this study was to investigate the role of glutamate/glutamine ...
Okada Emiko - - 2013
Perfluoroalkyl acids (PFAAs) are persistent organic pollutants that are used in a wide range of consumer products. Recent epidemiological studies have shown that prenatal exposure to toxic levels of PFAAs in the environment may adversely affect fetal growth and humoral immune response in infants and children. Here we have characterized ...
Barceló-Coblijn Gwendolyn - - 2013
Fetal alcohol syndrome is the most severe expression of the fetal alcohol spectrum disorders (FASD). Although alterations in fetal and neonate brain fatty acid composition and cholesterol content are known to occur in animal models of FASD, the persistence of these alterations into adulthood is unknown. To address this question, ...
Jones Kenneth Lyons - - 2013
Gastroschisis is a congenital abdominal wall defect where there is herniation of abdominal organs. Optimal maternal nutritional intake, in particular, fatty acids, are vital for proper growth and development of the fetus. This pilot case-control study explored the association of several biomarkers of fatty acids and gastroschisis. Between 2008 and ...
Giardini Valentina - - 2013
OBJECTIVES: To evaluate whether a relationship exists between season at conception and occurrence of Isolated Spina Bifida (ISB). STUDY DESIGN: All fetuses with prenatal diagnosis of ISB were analyzed according to date of conception. We compared the seasonal rates of conception between ISB fetuses and a control group consisting of ...
Larqué Elvira - - 2013
PURPOSE OF REVIEW: Placental nutrient uptake and transfer may have a unique role, as changes in trophoblast nutrient-sensing signaling pathways regulate cell metabolism and may affect the fetal growth and health programming in the offspring. RECENT FINDINGS: The functionality of the placenta could affect the neonatal adiposity and the fetal ...
Ashworth Cheryl J - - 2013
This study compared maternal plasma amino acid concentrations, placental protein secretion in vitro and fetal body composition and plasma amino acid and hormone concentrations in feto-placental units from the smallest and a normally-sized fetus carried by Large White×Landrace or Meishan gilts on Day 100 of pregnancy. Compared with Large White×Landrace, ...
Lamb Michelle - - 2013
This Report from the Field describes a folic acid awareness event hosted by a College of Pharmacy in conjunction with a local YWCA in observation of National Birth Defects Prevention Month and includes a discussion of the disparity between folic acid awareness and consumption and proposes a new tool to ...
Skilton Michael R - - 2012
BACKGROUND: Impaired fetal growth is independently associated with an increased risk of cardiovascular events in adulthood. Prevention strategies that can be implemented during adulthood have not been identified. OBJECTIVE: The objective was to determine whether habitual omega-3 (n-3) fatty acid intake is associated with the rate of increase of carotid ...
Tasdemir Seda - - 2012
Objective:  To determine the protective effects of hyaluronic acid and chondroitin sulfate in treating urinary tract infections in a rat model. Methods:  A total of 28 rats, which were induced with urinary tract infections through intravesical administration of Escherichia coli, were included in the study. By random selection, they were equally ...
Sun Yvonne - - 2012
Fatty acids (FAs) are the major structural component of cellular membranes, which provide a physical and chemical barrier that insulates intracellular reactions from environmental fluctuations. The native composition of membrane FAs establishes the topological and chemical parameters for membrane-associated functions and is therefore modulated diligently by microorganisms especially in response ...
Vences-Guzmán Miguel Á - - 2012
Ornithine lipids (OLs) are phosphorus-free membrane lipids that are widespread in eubacteria, but absent from archaea and eukaryotes. They contain a 3-hydroxy fatty acyl group attached in amide linkage to the α-amino group of the amino acid ornithine. A second fatty acyl group is ester-linked to the 3-hydroxy position of ...
Guo Wei - - 2012
The phytopathogenic prokaryote Xanthomonas oryzae pv. oryzae is the causal agent of bacterial leaf blight (BB) of rice and utilizes a type III secretion system (T3SS) to deliver T3SS effectors into rice cells. In this report, we show that the ketoglutarate transport protein (KgtP) is secreted in an HpaB-independent manner ...
Wang Jingxin - - 2012
There is a large range of diseases, such diabetes and cancer, which are connected to abnormal fatty acid metabolism in human cells. Therefore, inhibitors of human fatty acid synthase have great potential to manage or treat these diseases. In prokaryotes, fatty acid synthesis is important for signaling, as well as ...
Gao Minghui - - 2012
The roles of bacterial cellular components, namely, fatty acid profile and coenzyme A, in photocatalytic inactivation of bacteria were investigated. Escherichia coli BW25113, as a "parental strain", and its isogenic single-gene deletion mutants E. coli JW1081 (fabF(-) mutant) and E. coli JW3942 (coaA(-) mutant) showed different susceptibilities towards photocatalytic inactivation by titanium ...
Lewis Amanda L - - 2012
Sialic acids are nine-carbon-backbone sugars that occupy outermost positions on vertebrate cells and secreted sialoglycoproteins. These negatively charged hydrophilic carbohydrates have a variety of biological, biophysical, and immunological functions. Mucosal surfaces and secretions of the mouth, airway, gut, and vagina are especially sialoglycan-rich. Given their prominent positions and important functions, ...
Camci-Unal Gulden - - 2012
Herein we report the first synthesis of a 3-deoxy-d-manno-octulosonic acid (KDO) building block starting from glucose through pathway engineering of Escherichia coli and subsequent chemical modifications to provide an alternative method to produce KDO, found in plant and bacterial oligosaccharides.
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