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Karnitz L M - - 1984
Transport of [14C]pantothenic acid was studied using brush-border membrane vesicles prepared from rat kidney. In the presence of a Na+ gradient an accumulation of pantothenic acid 3-fold above equilibrium was observed. The Km and Vmax found were 7.30 microM and 23.8 pmol/mg protein per min, respectively. Isolated perfused rat kidneys ...
el-Essawy A A - - 1984
A strain of Azotobacter chroococcum was found to produce a considerable amount of cyanocobalamine especially when cultivated in a medium enriched with 0.3% ammonium chloride. Maximal production of the vitamin was achieved after six days of incubation in static cultures. The organism required molybdenum, iron (Fe++), cobalt and ascorbic acid ...
Cunningham J - - 1984
Previous studies in vitamin D deficient animals showing that acidosis may impair the production of 1,25(OH)2D3 are in conflict with studies in humans which have not shown convincing disturbances of 25OHD3 metabolism during acidosis. We have investigated the effect on renal 25OHD3 1- and 24-hydroxylase of acid loading for periods ...
Berkseth R - - 1984
When Renalin was used for reprocessing, the incidences of headache and hypotension were reduced and no changes in serum chemistries were noted. Dialyzer appearance was superior to that achieved with formaldehyde but accompanied by decreases in clearance of urea, creatinine, vitamin B-12 and a fall in KUF. While long-term patient ...
Nakajima K - - 1984
The effects of various compounds (0.5%) involved in the butanediol and the glycolytic pathways on riboflavin formation in whole cells of Ashbya gossypii at rest were examined. The addition of acetate, glycerol and diacetyl inhibited riboflavin formation, while the addition of acetoin had no effect on it, and the addition ...
Kaye M - - 1984
Clearance of urea, creatinine, phosphate and B12 in dialyzers reused up to 30 times were unchanged from the initial values. Residual formalin values were within acceptable levels and in several thousand dialyses no untoward reactions of any sort attributable to reuse were encountered. Neutropenia was constantly present with dialyzers prepared ...
van Doorne H - - 1984
The microbial contamination of 44 samples of a vitamin A preparation in sucrose syrup was investigated. The contaminants were almost exclusively yeasts and moulds. Microbiological and physicochemical studies showed that sorbic acid was the preservative of choice for this formulation. The results are discussed with respect to the preservation of ...
Makino-Tasaka M - - 1984
The blue-sensitive pigment of the green rods was purified by column chromatography with Con A-Sepharose 4B. In digitonin solution, the lambda max and the epsilon max values of the green rod pigment were 430 nm and 35,000, respectively, for the vitamin A1-based pigment (P-4301). P-4301 was destroyed by hydroxylamine and ...
Sivell L M - - 1983
Samples of white and brown bread, both sliced and unsliced, and of wheatgerm breads and wholemeal bread were purchased in London and analysed for a wide range of nutrients. Available carbohydrate, dietary fibre, fatty acids, riboflavin, vitamin B6, and iodine were determined in bulked samples of each type of bread ...
McTigue J J - - 1983
The rat liver vitamin K-dependent carboxylase has been studied with t-butoxycarbonyl-Glu-Glu-Leu-OMe as a substrate. The crude enzyme preparation catalyzes incorporation of 3H from media 3H2O into the glutamic acid residues of the substrate. This incorporation is dependent on vitamin KH2 and O2, is stimulated by NaCN, and is inhibited by ...
del Ser Quijano T - - 1983
The relationship between serum folate level and psychological disturbances was studied in a series of 95 chronic epileptic outpatients. All were nondrinkers. Serum folic acid in all cases and vitamin B12 in 83 cases were determined by radioimmunoassay. Only three factors were significantly related with psychological disturbances: serum levels of ...
Chen M - - 1983
Three holding media, including the vitamin-free Casitone holding medium (m-VFC) recommended by Standard Methods for the Examination of Water and Wastewater for use with the delayed-incubation membrane filter procedure, were compared for their ability to maintain viability of fecal coliforms. Each medium was tested according to the procedure described in ...
Sklan D - - 1983
The effect of high dietary vitamin A or tocopherol, or both, on lipid absorption and secretion in the gastrointestinal tract and on serum and hepatic lipids was determined in the chick. High dietary vitamin A increased secretion of cholesterol, bile acids, phospholipids and fatty acids to the duodenum, and tocopherol ...
Bhat P V - - 1983
A study was conducted on the incorporation of [11-3H]retinyl acetate into various retinyl esters in liver tissues of rats either vitamin A-sufficient, vitamin A-deficient or vitamin A-deficient and maintained on retinoic acid. Further, the metabolism of [11-3H]retinyl acetate to polar metabolites in liver tissues of these three groups of animals ...
Ellinghausen H C HC - - 1983
Nutrient requirements of Leptospira interrogans serovar hardjo were investigated using a 1% bovine serum albumin (BSA) medium, supplemented separately with polysorbates (Tweens) 80, 60, 40, 20, NH4Cl, and vitamins thiamine and cyanocobalamin (vitamin B12). L. hardjo was tested in vitro against 30 antibacterial compounds incorporated into semisolid medium (0.2% agar) ...
Nerad T A - - 1983
Chemically defined minimal media for the cultivation of high temperature tolerant and pathogenic Naegleria spp. have been developed. A defined minimal medium, identical for N. fowleri and N. lovaniensis, consists of eleven amino acids (arginine, glycine, histidine, isoleucine, leucine, methionine, phenylalanine, proline, threonine, tryptophan, and valine), six vitamins (biotin, folic ...
Ford J E - - 1983
Storage of milk powder under unfavourable conditions accelerates the normally slow deterioration in nutritional quality. The effects of such storage on the water-soluble vitamin composition were examined. (a) Spray-dried whole milk containing 25 g water/kg was stored at 60 degrees and 70 degrees and sampled weekly to 9 weeks. (b) ...
Bhatia J - - 1983
In neonatal nurseries, solutions of amino acids with added vitamins may be exposed to relatively intense light from phototherapy units. Light, especially in the presence of photosensitizers such as certain vitamins, is capable of destroying amino acids. In the present study, the effect of riboflavin on amino acid concentrations in ...
van der Westhuyzen J - - 1983
The effects of vitamin B-12 deficiency on lipids and fatty acids of spinal cord myelin were studied in control and vitamin B-12-deficient fruit bats. Very low plasma and brain vitamin B-12 concentrations were present in animals fed the vitamin B-12-free, all fruit diet. Myelin was isolated from the spinal cord ...
Leigh J A - - 1983
The levels of seven water-soluble vitamins in Methanobacterium thermoautotrophicum, Methanococcus voltae, Escherichia coli, Bacillus subtilis, Pseudomonas fluorescens, and Bacteroides thetaiotaomicron were compared by using a vitamin-requiring Leuconostoc strain. Both methanogens contained levels of folic acid and pantothenic acid which were approximately two orders of magnitude lower than levels in the ...
Kabakoff B - - 1983
The ability of four vitamin D analogs to inhibit the liver microsomal vitamin D-25-hydroxylase was determined. 19-Hydroxy-10(S),19-dihydrovitamin D3,25-fluorovitamin D3, 3 beta-hydroxy-9,10-seco-5,7,10(19)-choletrien-24-oic acid dimethylamide and 25-aza-vitamin D3 were competitive inhibitors with apparent KI values of 44, 137, and 870 nM, and 6.4 microM, respectively. The values for the 19-hydroxy-10(S), 19-dihydrovitamin D3, ...
Czarnecki G L - - 1983
Experiments were conducted with crossbred chicks to examine the growth response to a vitamin when its precursor amino acid was in either deficient or adequate supply in the diet and vice versa. The tryptophan-niacin and methionine-choline interrelationships were thus examined. No growth responses to dietary niacin or choline were observed ...
Bronckers A L - - 1983
Second maxillary molars of hamsters were cultured in the presence or absence of 250 micrograms/ml vitamin C for periods up to 12 days. At various days, cultured explants were studied with histological and biochemical methods to investigate effects of vitamin C-deficiency on matrix production and mineralization in vitro. As biochemical ...
Sietsema W K - - 1982
A method is described for measuring the relative activities of vitamin A active substances based on their direct effect on the cornified vaginal epithelium of vitamin A-deficient rats. The results obtained agree well with those found in the tracheal organ culture assay. The relative activities found for several test compounds ...
Watson W S - - 1982
Radiotracer B12 analogues, hydroxy- and cyano-cobalamin have been used to study the effects of megadose L-ascorbic acid (vitamin C) ingestion on vitamin B12 metabolism in man. By employing whole body counter techniques it has been shown that, while ascorbic acid can partially inactivate both the important dietary analogue, hydroxycobalamin, and ...
Putkey J A - - 1982
Vitamin D-3 and its metabolites regulate the transport of calcium across the intestinal epithelial cell via a mechanism which is as yet unknown. The purpose of this study was to evaluate the effect of an essential fatty acid deficiency on vitamin D-stimulated intestinal calcium transport as measured by both in ...
Hamer A - - 1982
The potentiation of the anticoagulant effect of sodium warfarin by amiodarone is reported in 10 patients. Amiodarone appears to augment the depression of vitamin K-dependent coagulation factors caused by warfarin by an uncertain mechanism, and may lead to serious bleeding. The maintenance dose of warfarin should be halved when amiodarone ...
Ringsdorf W M WM - - 1982
Clinical studies provide evidence that wound healing in subjects judged not deficient in vitamin C can be significantly accelerated with supplements of this nutrient above the recommended daily allowance (RDA). The authors administered daily dosages of 500 to 3,000 mg., which is roughly 8 to 50 times the RDA of ...
Uotila L - - 1982
Vitamin K is required for the posttranslational modification of liver precursors of prothrombin, blood coagulation Factors VII, IX, and X and additional proteins of undetermined functions in plasma and other tissues. This modification involves the formation of gamma-carboxyglutamic acid, an acidic amino acid needed for the interaction of these proteins ...
Lampart-Szczapa E - - 1982
The research on pangamic acid (vitamin B15) has been conducted by specialists in many fields of science for along time. This, however, has not put an end to controversies around the problem of its therapeutic effect. The solution to the basic problems, i.e. defining the compound structure, finding an explicit ...
Burns R A - - 1982
1. Control, folate-deficient and vitamin B12-supplemented chickens were given [3', 5', 9 (n)-3H] pteroylglutamic acid by intraperitoneal injection. After various time intervals (1.5 h-8d) the incorporation of radioactivity into hepatic folate derivatives was measured. 2. The results confirm that avian species have a faster assimilation of folate than most mammalian ...
Matsui M S - - 1982
The effect of certain drugs on nutrient metabolism is discussed. Antituberculotic drugs such as INH and cycloserine interfere with vitamin B6 metabolism and may produce a secondary niacin deficiency. Oral contraceptives interfere with the metabolism of folic acid and ascorbic acid, and in cases of deficient nutrition, they also seem ...
Robison W G - - 1982
Relatively high proportions of long-chain, polyunsaturated fatty acids seem to be required in rod photoreceptor membranes in order to provide the precise microenvironment for the proper function of the visual pigment rhodopsin. At the same time, such high levels of lipid unsaturation put the photoreceptor membranes at a high risk ...
Butturini U - - 1982
The major pathogenetic factors of the atherosclerotic diseases are: a) vasal endothelium distress; b) rheological disturbs; c) alterations in plasma lipid pattern; d) dietary intake of saturated and polyunsaturated fatty acids; e) alteration of mitochondrial and microsomal membranes; f) vascular injury induced by immune complexes; g) increased lipid peroxidations. Many ...
Fidanza A - - 1982
Vitamins play an essential role in lipid metabolism reactions and their presence is therefore absolutely necessary for these reaction to occur. The effect of pantothenic acid, niacin and riboflavin is here described. By transformation into coenzymes these vitamins are involved in fatty acid synthesis and oxidation reactions. Other vitamins, like ...
ten Hove W - - 1982
This report describes various clinical and micro-nutrient abnormalities that existed in a 47-year-old woman who underwent a jejunoileal bypass operation. She exhibited extensive electrolyte, mineral, amino acid, and vitamin deficiencies. Amino acid absorption tests indicated an inability to absorb essential amino acids, especially the branched-chain and aromatic varieties. Vitamin absorption ...
Verma K K - - 1981
A titrimetric method is described for the determination of isoniazid in pharmaceutical preparations. Samples are treated with an excess of iodine monochloride, and the iodine produced is titrated with iodine trichloride to an Andrews end-point. p-Aminosalicylic acid undergoes only nuclear iodination and does not interfere. Mixtures of isoniazid with vitamin ...
Yagishita K - - 1981
The investigation of mechanism of synergistic action with SYN and ECZ was performed using C. albicans SC5314 so that SYN was confirmed to show strong synergistic effects against Candida sp. in particular with addition of extremely small quantities under the MICs of imidazole antimycotics such as ECZ, MCZ and CTZ. ...
Resnick I G - - 1981
A membrane filter technique has been developed for the enumeration of bifidobacteria in natural aquatic environments. The technique is quantitative, selective, and differential. The medium (YN-6) contains: yeast extract, 2.0 g; agar, 1.5 g; polypeptone peptone, 1.0 g; vitamin-free Casamino Acids, 0.8 g; sodium chloride, 0.32 g; and L-cysteine hydrochloride, ...
Srinivasan V - - 1981
Pantothenic acid nutritional status was evaluated in 37 men (32 noninstitutionalized and five institutionalized) and 54 women (33 noninstitutionalized and 21 institutionalized) 65 yr of age or older. A fasting blood sample, a 24-h urine specimen and a food consumption record for 1 wk were obtained from each subject. Hematological, ...
Rudin D O - - 1981
Pellagra was once a major cause of three behaviorally different mental disorders-schizophreniform, manic-depressive-like, and phobic neurotic - plus drying dermatoses, autonomic neuropathies, tinnitus, and fatigue. In this preliminary study all three of the corresponding present-day mental diseases are found to exhibit, statistically, the same pellagraform physical disorders but to ameliorate ...
Wark J D - - 1981
1. Isolated renal tubules were prepared from vitamin D-deficient chicks. The effects of added prostaglandin E2 (PGE2) and agents which modify prostaglandin metabolism on the metabolism of 25-hydroxy-vitamin D3 were studied. 2. Frusemide (0.1 mmol/l) raised the prostaglandin E (PGE) content of the tubule incubation medium; it significantly increased 1,25-dihydroxy-vitamin ...
Medinsky M A - - 1981
Selenium compounds released into urban atmospheres as a result of fossil fuel combustion may pose an inhalation hazard to people. Two chemical forms of selenium produced during coal combustion and present in combustion effluent are selenious acid. H2SeO3, and elemental selenium, Se. In an attempt to determine the toxicity of ...
Rautureau M - - 1981
Jejunal aqueous solubilisation of vitamin D3 was assessed in eight normal subjects, after ingestion of a standard liquid test meal. Percentages and total concentrations of vitamin D3 in the aqueous phase were significantly higher in the first post-prandial 30 minutes than during the following two hours, as were bile salts, ...
Thomas J R JR - - 1981
Topical vitamin A acid (VAA) has various mechanisms of action which may be responsible for its therapeutic success in many different disorders. Although the absorption, metabolism, and excretion of VAA are not completely understood, VAA appears to remain mainly on the skin surface. The question of carcinogenicity is unresolved, and ...
McCarty M F - - 1981
A broad-spectrum approach to the nutritional optimization of bioenergetics is discussed as a specific example of the principle of functional orthomolecular supplementation. Experimental and clinical studies with "metavitamins" such as lipoic acid, carnitine, coenzyme Q, and creatine, and with mitochondrial antioxidants, indicate that many nutritional agents involved in bioenergetics are ...
Teo N H - - 1981
The effect of conjugated and unconjugated bile acids on the binding of vitamin B12 to intrinsic factor was investigated. The dihydroxy bile acids (deoxycholic, glycodeoxycholic, taurodeoxycholic, glycochenodeoxycholic, and taurochenodeoxycholic) inhibit the binding of intrinsic factor to vitamin B12 at physiological concentrations. On the other hand, the trihydroxy bile acids (cholic, ...
Viogt M N - - 1981
The dosages of aflatoxin B1 (AFB1) required to produce significant changes in concentrations of B vitamins in plasma and bile and of amino acids in plasma of rabbits were determined. Folate increased by 98% in plasma, whereas concentration of thiamine, vitamin B6, and biotin decreased by more than 50%. In ...
Inoue S - - 1981
A 7-week-old infant with methylmalonic acidemia had pancytopenia and hypoplastic bone marrow. The patient responded to large doses of vitamin B12 treatment, and within 3 wk, the blood counts and bone marrow cellularity returned to normal. To understand the mechanism of marrow depression in this infant, we examined the effect ...
Freed B A - - 1981
A retrospective study was undertaken to determine with what frequency one of the 12 standard enteral formulations routinely used by the Metabolic Support Service could not be used without modification. Forty-three percent of the 83 patients studied required modification of one or more of the 5 individual components of the ...
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