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Miller S J - - 1989
Cutaneous changes occur in deficiency states of many nutritional elements: ascorbic acid, retinol, protein-energy, cyanocobalamin, phytonadione (vitamin K), biotin, ribroflavin, pyridoxine, niacin, essential fatty acids, and zinc. There are also inherited disorders of copper, biotin, zinc, and tryptophan metabolism. Cutaneous vitamin D synthesis is inhibited by sunscreen use. The striking ...
Vécsei L - - 1989
Cysteamine (1.95 mM/kg) markedly decreased the locomotor, rearing and grooming activities, as well as the number of defecation boluses in an open-field test. An equimolar dose of pantethine reduced the locomotor activity to a lesser extent, but has the same potency in decreasing the number of defecation boluses, whereas pantothenic ...
Nnanna I A - - 1989
Amino acid composition, protein digestibility, calculated protein efficiency ratio (C-PER and DC-PER), chemical scores and water-soluble vitamin content of cowpea seeds germinated at 25 degrees C or 30 degrees C for 24 h were determined. Also, the effect of processing steps (heated-air drying, decortication and cooking) on these parameters were ...
Mukai K - - 1989
New stable vitamin E radicals (7-tert-butyl-5-isopropyltocopheroxyl (4), 5,7-diisopropyltocopheroxyl (5), 7-tert-butyl-5-methyltocopheroxyl (6), and 5,7-diethyltocopheroxyl (7] with two bulky alkyl substituents at ortho positions (C-5 and C-7) have been prepared, and the reaction rates of vitamin C (ascorbic acid (1) and 6-O-stearyl ascorbic acid (2] with these tocopheroxyl radicals in benzene/ethanol/water (2:1:0.1, ...
Popp J L - - 1989
An early enzyme in menaquinone (vitamin K2) biosynthesis is the synthase forming 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) from isochorismic acid. In turn, SHCHC is aromatized to o-succinylbenzoic acid (OSB) by OSB synthase. An assay for the combined activity of these two enzymes ("overall OSB synthesis") has been developed using a high-performance liquid ...
Kurumaya K - - 1989
Recently the amide-oxygen has been suggested to participate in the formation of the corrin ring of vitamin B12. To confirm this hypothesis, 17O-labeled aminolevulinic acid (ALA) was prepared and administered to Propionibacterium shermanii. The isolated vitamin B12 showed only broad 17O signals in the oxygen-17 nuclear magnetic resonance (17O-NMR) spectrum. ...
Chen L H - - 1989
Ascorbic acid appears to have two opposite roles in animal tissues: to act as an antioxidant or to act as a prooxidant. The effects of ascorbic acid supplementation on the tissue antioxidant status seem to be dependent on the dose of ascorbic acid and the vitamin E status. Adequate doses ...
Guilarte T R - - 1989
A semi-automated radiometric-microbiological assay (RMA) was developed and applied for the analysis of pantothenic acid in human blood and milk. The RMA is based on the measurement of 14CO2 produced from the metabolism of L-[1-14C]methionine or L-[1-14C]valine by the yeast Kloeckera brevis in the presence of pantothenic acid. The assay ...
Reddy G S - - 1989
About a decade ago calcitroic acid was isolated as a major side chain cleaved water-soluble metabolite of 1,25-dihydroxyvitamin D3 [Esvelt, R. P., Schnoes, H. K., & Decula, H. F. (1979) Biochemistry 18, 3977]. Presently, calcitroic acid is being considered as the major excretory form of 1,25-dihydroxyvitamin D3. However, the exact ...
Silva A E - - 1989
Plasma folic acid and vitamin B12 levels of 21 heterozygous beta-thalassemic patients from São José do Rio Preto, SP, Brazil did not differ from those of family member controls or of controls matched for age, sex and socioeconomic status. All values were within the normal range for folic acid (3-17 ...
Hess D - - 1989
The two vitamin B6-vitamers having an aldehyde function are oxidised to the corresponding acids and subjected to an HPLC separation on an RP 18 phase with a solvent consisting of 5% methanol in phosphate buffer at pH 3.5. The detection is carried out by fluorometry with excitation at 318 nm ...
Shemin D - - 1989
In this article, David Shemin, who is now in retirement, describes how in 1944 he ingested 66 g of 15N-labeled glycine in order to determine the half-life of hemoglobin and other blood proteins. The ramifications of the experiment led to the unravelling of the biosynthesis of porphyrins and the role ...
Snell E E - - 1989
From the above discussion, it is apparent that one or another of the lactic acid bacteria requires each of the B vitamins required by animals and that assay methods developed during study of nutrition of bacteria and yeasts have played a large role in the initial or independent discovery, isolation, ...
Tibbitts J S - - 1989
The effect of biliary diversion on the ability of cefamandole, a methyltetrazole-thiol (MTT) containing antibiotic, to alter both hepatic vitamin K metabolism and the gamma-carboxylation of glutamic acid were examined in the rat, in order to understand the hypoprothrombinemia associated with MTT-containing antibiotics. At a dose of 3 gm/kg, cefamandole ...
Davis W L - - 1989
The effect of vitamin-D deficiency and subsequent vitamin-D replacement on the metabolism of rat epiphyseal growth plate cartilage was studied. Biochemical analyses showed the presence of the two unique glyoxylate cycle enzymes isocitrate lyase and malate synthase in cartilage. The activity of these enzymes was markedly increased after treatment with ...
Buttriss J L - - 1988
(1) Rats were given a diet deficient in vitamin E and selenium, or diets supplemented with either or both of these nutrients. The livers were subfractionated by standard procedures, and the purity of the fractions was assessed by marker enzyme techniques. alpha-Tocopherol was measured and profiles of phospholipid fatty acids ...
Blum K - - 1988
We investigated the effects of the amino acid and vitamin mixture SAAVE in inpatient, chemically-dependent subjects to evaluate the role of neurotransmitters in facilitating recovery and adjustment to a detoxified, sober state. SAAVE is formulated from amino acids that are precursors for neurotransmitters and neuromodulators thought to be involved in ...
Tjoelker L W - - 1988
The interaction of dietary vitamin A and beta-carotene with lactational status on the in vitro proliferation of mitogen-induced peripheral blood lymphocytes was studied. Cows were fed (IU/cow per d) 1) 53,000 IU vitamin A, 2) 213,000 IU vitamin A, or 3) 53,000 IU vitamin A plus 400 mg beta-carotene from ...
Cockroft D L - - 1988
Rat embryos explanted at 9.0, 9.5, and 10.5 days of gestation were cultured for periods of 61, 49, or 45 h, respectively, in extensively dialysed rat serum supplemented with various combinations of glucose, amino acids, and vitamins. Glucose was found to be a necessary and sufficient energy source for embryos ...
Smith J L - - 1988
This study was designed to determine the stability of certain vitamins added to total parenteral nutrition (TPN) admixtures with or without Intralipid iv fat emulsion and with each of four amino acid solutions stored in either glass bottles or plastic bags at either ambient room (25 degrees C) or refrigerator ...
Kim C I - - 1988
Liver plasma membranes (LPM) were prepared from vitamin A-deficient and -sufficient rats as well as from animals treated with retinoic acid, with or without ethanol. Although the fluorescence polarization value of LPM prepared from retinoic acid-fed animals was significantly lower than that of controls (0.201 +/- 0.008 vs. 0.254 +/- ...
Boskey A L - - 1988
Calcium acidic phospholipid phosphate complexes cause hydroxyapatite formation in vitro and in vivo. Previous studies have shown that the amount of these complexed acidic phospholipids is altered in the bones of animals depleted of vitamin D and phosphate. To help differentiate the effects of vitamin D from those due to ...
Shimizu S - - 1988
Ketopantoic acid reductase (EC 1.1.1.169), an enzyme that catalyzes the formation of D-(-)-pantoic acid from ketopantoic acid, was purified 6,000-fold to apparent homogeneity with a 35% overall recovery from Pseudomonas maltophilia 845 and then crystallized. The relative molecular mass of the native enzyme, as estimated by the sedimentation equilibrium method, ...
Smith J L - - 1988
The three sections of this study extend previous research into losses of vitamins A, C, E, thiamin, riboflavin, and folic acid from total parenteral nutrition (TPN) admixtures. First, phototherapy light on TPN admixtures containing one of four amino acid solutions was studied. Experimental conditions included presence or absence of Intralipid ...
Ilic D B - - 1988
Plain and raspberry flavored low fat yogurt samples were fortified with various commercial forms of vitamins A and C under actual production conditions. Immediately after processing, yogurt samples were kept at 3 degrees C for 6 wk and were analyzed biweekly for pH, titratable acidity, and vitamins A and C. ...
Noda S - - 1988
Three senile patients developed fatal acute encephalopathy while receiving calcium hopantenate. The clinical, biochemical, and pathological picture was similar to Reye's syndrome. Calcium hopantenate is a pantothenic acid antagonist. The serum levels of calcium hopantenate were high in coma, and that of pantothenic acid examined in one patient was lowered. ...
Urano S - - 1988
Either alpha-tocopherol (vitamin E) or one of its model compounds having side chains of different length at the 2-position of alpha-tocopherol, forms complexes with an unsaturated fatty acid in methanol. For complex formation, the isoprenoid side chain and hydroxy group of alpha-tocopherol are unessential and, rather, the methyl groups attached ...
Airas R K - - 1988
A pseudomonad was separated having a pantothenase that produced beta-alanine and pantoic acid. The pantothenase from an old strain, Pseudomonas fluorescens UK-1, was shown to produce beta-alanine and pantoyl lactone. The pantoic acid-producing pantothenase was characterized and compared with the pantothenase from the strain UK-1. The Mr was 240,000; it ...
Suzuki T - - 1988
Weanling, male albino mice were placed on a vitamin A-free diet for three months to deplete their vitamin A stores. The vitamin A-deficient mice were injected intraperitoneally with all-trans 3-dehydroretinol. 3-dehydroretinol was rapidly incorporated into the liver as a fatty acid ester. The chromophore of visual pigment increased gradually and ...
Bano Z - - 1988
The fruit bodies of Pleurotus species as a class of "Edible Fungal Foods" have been discovered to have definite nutritive and medicinal values. They are a good source of nonstarchy carbohydrates, dietary fiber (that can help in reducing the plasma cholesterol), most of the essential amino acids, minerals and vitamins ...
Davis R H - - 1988
Investigation of the dietary interaction between cyanide and selenium in the chick, whereby cyanide alleviates selenium toxicity, suggests that cyanide alters metabolic reductive potential. Cyanide enhances the elimination of selenium as dimethyl selenide, the formation of which requires both reducing equivalents and methyl groups. Even when the methionine supply is ...
Cunnane S C - - 1988
The influence of dietary vitamin E on the composition of essential fatty acids in rat tissue and plasma lipids as well as serum thromboxane B2 was studied. Diets containing deficient (0 mg/kg diet), adequate (100 mg/kg) or supplemental (1,000 mg/kg) vitamin E were fed to young male rats for 10 ...
Boskey A L - - 1988
Vitamin D deficiency is known to cause alterations in the lipid and mineral components of bone and cartilage. In this study, second generation, normal phosphatemic, vitamin D-deficient rats, treated with low and high doses of three different vitamin D metabolites were sacrificed 24 h after treatment and their bones analyzed ...
Stein G - - 1988
Many factors complicate the effort for a recommendation on individual vitamin requirements in CRF. On the basis of our present incomplete knowledge about the handling of vitamins in uremia, suggestions for appropriate supplementation only of water-soluble vitamins are given. Patients with advanced CRF without dialysis treatment should receive daily supplements ...
Tolonen M - - 1988
About 25% of Finnish and Dutch elderly appeared to be more or less deficient in vitamin B6 as compared to younger adults. Deficiency was observed at the cellular (PLP, EGOT and alpha-EGOT) as well as at the plasma level (PLP). The benefit of a one-year daily supplementation with 2 mg ...
Scott A I - - 1987
13C NMR spectroscopy has been used to locate six deuterium atoms incorporated biosynthetically on the periphery of the corrin nucleus of vitamin B12 (cyanocobalamin) derived from cells of Propionibacterium shermanii grown in a medium containing 50% 2H2O and 13C-enriched delta-aminolevulinic acid. The implications of these results for the mechanism of ...
Bourre J M - - 1987
In the brain of quaking and shiverer mutants, vitamin E content was normal when related to both wet weight and dry weight. When related to lipid extract, phosphorus, and polyunsaturated fatty acids, vitamin E was slightly increased only in the quaking mutant. In the sciatic nerve from trembler mutants, vitamin ...
Mahoney M J - - 1987
Methylmalonic acidemia results from decreased activity of methylalonyl-CoA mutase, an enzyme required for the catabolism of four amino acids. A cobalamin (vitamin B12) compound is required as coenzyme. Several inherited mutations of the mutase apoenzyme or of cobalamin coenzyme synthesis have been identified. Clinical disease is most commonly recognized as ...
Matsuoka L Y - - 1987
Sunscreens block the cutaneous absorption of UV-B radiation and prevent sunburning, premature aging, and cancer of the skin. Inasmuch as UV-B radiation is also responsible for the photosynthesis of vitamin D3, we investigated the effect of sunscreens on the cutaneous formation of vitamin D3 in vivo and in vitro. Eight ...
Luk C K - - 1987
The effects of external nutrients on the growth and radiation response of EMT6/Ro spheroids were studied by maintaining spheroids in media with different concentrations of glucose, amino acids, and vitamins. Compared to spheroids grown in normal glucose concentration (5.5 mM), spheroids grown in higher glucose media (24.8 mM), demonstrated no ...
Bowers J A - - 1987
As part of the USDA's effort to obtain accurate data for nutrient composition handbooks, we determined proximate composition and vitamin (thiamin, riboflavin, niacin, folacin, pantothenic acid, and vitamins B-6 and B-12) content of fast-food fried chicken. Ninety-four samples were purchased from six chains in 10 cities throughout the United States. ...
Matchar D B - - 1987
Vitamin B12 deficiency is a frequently considered diagnosis for which there is no single, commonly available and accurate test. A urinary methylmalonic acid assay using gas chromatography-mass spectrometry has been proposed as the preferred test. We reviewed vitamin B12 assays on 1599 consecutive patients and prospectively studied all patients with ...
GrodziƄska L - - 1987
Nitrendipine (Bayotensin) is a dihydropyridine derivative that appears to preferentially dilate peripheral vessels by a cellular mechanism similar to those found with other calcium blocking agents. In this study nitrendipine when infused (0.2-0.3 mg/kg i.v.) into anaesthetized cats caused a release of a substance disaggregating platelet clumps which had adhered ...
Jha K - - 1987
It is a well-known fact that the legume Khesari (Lathyrus sativus) causes lathyrism, a disease characterized by paralysis of the lower limbs in human beings. The toxic constituent is an amino acid identified as B-Oxalyl-Amino L-Alanine (BOAA). It has been reported that if the legume is boiled for two hours ...
Juhász O - - 1987
Musts of 11 different grape sorts were analyzed for titratable acids, total sugars, nitrogen, vitamin B group (B1, B2, B6, pantothenic acid) and macro- and micro elements (K, Ca, Mg, Fe, Zn, Cu, Mn, Mo). Analyses were done on samples collected in 1983 and 1984. The nutritive value of each ...
Ekundayo C A - - 1987
The fungi most frequently isolated (of 20-100% incidence) from fresh okra, pepper fruits and melon seeds are Botryodiplodia theobromae, Rhizopus stolonifer, Trichoderma harzianum, Mucor mucedo and Fusarium oxysporum. The major mycoflora of the fruits which had been sun-dried for twenty days are comprised of Aspergillus spp and Penicillium spp which ...
Porrini M - - 1987
The vitamin A, E and C nutritional status of 313 non institutionalized elderly people living in a small town and in an agricultural village of North Italy has been evaluated. From results obtained it is possible to say that all the population tested is at low risk for vitamin A ...
Pocker Y - - 1987
This paper presents a series of experiments that define the energetics of liver alcohol dehydrogenase and allow the construction of a free energy profile for the ethanol-acetaldehyde interconversion. Because of its broad specificity, we have also performed a series of kinetic studies designed to test the metabolic efficiency and the ...
Tandon S K - - 1987
The supplementation of vitamin-B complex reduces lead intoxication. With a view to identify the components of vitamin-B complex responsible for such protection, riboflavin, calcium pentothenate, pyridoxine, nicotinamide, folic acid and cyanocobalamine were investigated for their ability, and their influence on the efficacy of disodium calcium versenate (Na2CaEDTA), to enhance the ...
Ackerman L - - 1987
Nutritionally-related dermatoses of dogs have received considerable attention in the veterinary community in the past few years and most of this attention has centered on the role of vitamin E, vitamin A, zinc, and the essential fatty acids. Nutritional supplements for dogs abound in the marketplace yet few actually meet ...
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