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Ferreira Miguel F MF Centro de Química (CQ-UM), Universidade do Minho, Campus de Gualtar, 4710-057 Braga, Portugal. - - 2014
The availability of commercial (68)Ge/(68)Ga cyclotron-independent (68)Ga(3+) generators is making Positron Emission Tomography (PET) accessible to most hospitals, which is generating a surge of interest in the design and synthesis of bi-functional chelators for Ga(3+). In this work we introduce the NO2A-N-(α-amino)propionic acid family of chelators based on the triazacyclononane ...
Ishimaru Hideki H 1 Department of Radiology, National Hospital Organization Nagasaki Medical Center, Omura, - - 2014
OBJECTIVE. The purpose of this article is to investigate whether there is a difference in susceptibility to transcatheter arterial chemoembolization between hepatocellular carcinomas (HCCs) showing high uptake and those showing low uptake of gadoxetic acid in the hepatobiliary phase of MRI. MATERIALS AND METHODS. One hundred HCCs that achieved optimal ...
Nikrad Mrinalini P MP School of Marine Science and Policy, University of Delaware, Lewes, DE - - 2014
Heterotrophic bacteria are well known to be key players in the turnover of dissolved organic material (DOM) in the oceans, but the relationship between DOM uptake and bacterial clades is still not well understood. Here we explore the turnover and single-cell use of glucose, an amino acid mixture, N-acetyl glucosamine ...
Dong Shubin S Lab of Systematic Evolution and Biogeography of Woody Plants, College of Nature Conservation, Beijing Forestry University, Beijing 100083, PR - - 2014
Acyl-acyl carrier protein (ACP) thioesterases (TE EC 3.1.2.14) are fatty acid biosynthesis key enzymes that determine fatty acid carbon chain length in most plant tissues. A full-length cDNA corresponding to one of the fatty acyl-ACP thioesterase (Fat) genes, designated LcFatB, was isolated from developing Lindera communis seeds using PCR and ...
Akulov Katherine - - 2014
Femtosecond UV-Vis pump-probe spectroscopy was employed to study the acid effect on curcumin in the excited state. Curcumin in solutions of weak acids was found to be a photobase forming a protonated curcumin within a few tens of picoseconds from the time of excitation. The excited-state-protonation reaction is also observed ...
Wang Min M Department of Radiology and Imaging Sciences, Indiana University School of Medicine, 1345 West 16th Street, Room 202, Indianapolis, IN 46202, - - 2014
The reference standard 2-fluoro-4-(1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)vinyl)benzoic acid was synthesized from 2,5-dimethyl-2,5-hexanediol and 2-fluoro-4-methylbenzoic acid in 10 steps with 3% overall chemical yield. The precursor 2-nitro-4-(1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)vinyl)benzoic acid was synthesized from 2,5-dimethyl-2,5-hexanediol and dimethyl-2-nitroterephthalate in seven steps with 2% overall chemical yield. The target tracer 2-[(18)F]fluoro-4-(1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)vinyl)benzoic acid was synthesized from its nitro-precursor by the ...
Andrews M M Micronutrient Laboratory, Institute of Nutrition and Food Technology (INTA), University of Chile, El Líbano 5524, Macul, Santiago, - - 2014
Calcium, phytic acid, polyphenols and fiber are major inhibitors of iron absorption and they could be found in excess in some diets, thereby altering or modifying the iron nutrition status. The purpose of this study is to evaluate the effect of calcium, tannic acid, phytic acid, and pectin over iron ...
Schneider Hannah H Molecular Cell Biology Laboratory Internal Medicine IV, University of Heidelberg, Im Neuenheimer Feld 345, 69120 Heidelberg, - - 2014
The mechanism of cellular fatty acid uptake is highly relevant for basic and clinical research. Previous work has demonstrated that fatty acid uptake is facilitated by cell surface membrane proteins as well as by intracellularly localized enzymes. Here, the exogenous expression of the CD36/FAT glycoprotein and the acyl-CoA synthetases FATP4 ...
Jepperson Maria A MA Mayo Clinic Jacksonville, Jacksonville, Florida, - - 2014
Dual energy computed tomography (DECT) utilizes the material change in attenuation when imaged at two different energies to determine the composition of urinary calculi as uric acid or non-uric acid. We discuss a series of case reports illustrating DECT's ability to provide immediate determination of uric acid versus non-uric acid ...
Hu Lina Y LY Department of Biomedical Engineering, University of California Davis, Davis, CA, - - 2014
The integrin αvβ6 is overexpressed in a variety of aggressive cancers and serves as a prognosis marker. This study describes the conjugation, radiolabeling, and in vitro and in vivo evaluation of four chelators to determine the best candidate for (64)Cu radiolabeling of A20FMDV2, an αvβ6 targeting peptide. Four chelators were ...
Khalifeh-Soltani Amin A 1] Cardiovascular Research Institute, University of California, San Francisco, San Francisco, California, USA. [2] Lung Biology Center, University of California, San Francisco, San Francisco, California, USA. [3] Department of Medicine, University of California, San Francisco, San Francisco, California, - - 2014
Fatty acids are integral mediators of energy storage, membrane formation and cell signaling. The pathways that orchestrate uptake of fatty acids remain incompletely understood. Expression of the integrin ligand Mfge8 is increased in human obesity and in mice on a high-fat diet, but its role in obesity is unknown. We ...
Cheng Xiao X State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University , Changchun 130012, P. R. - - 2014
A novel family of organoboron compounds 1-4 with bright near-infrared (NIR) emissions in the crystalline state was synthesized. They show a morphology-dependent emission "ON" and "OFF" feature and volatile acid/base-induced fluorescence saltation which allow the realization of reversible solid-state fluorescence switching in the NIR region by totally different procedures: mechanical ...
Valan Arasu Mariadhas M Grassland and Forage Division, National Institute of Animal Science, RDA, Cheonan, South - - 2014
Adipogenesis is very much important in improving the quality of meat in animals. The aim of the present study was to investigate the in vitro and in vivo adipogenesis regulation properties of Lolium multiflorum on 3T3-L1 pre-adipocytes and mice. Chemical composition of petroleum ether extract of L. multiflorum (PET-LM) confirmed ...
Erez Yuval - - 2014
Steady-state and time-resolved emission techniques were employed to study the acid-base effects on the UV-Vis spectrum of curcumin in several organic solvents. The fluorescence-decay rate of curcumin increases with increasing acid concentration in all the solvents studied. In methanol and ethanol solutions containing about 1M HCl, the short-wavelength fluorescence (λ<560nm) ...
Dubikovskaya Elena E Department of Chemistry, École Polytechnique Fédérale de Lausanne, Lausanne, - - 2014
The ability of white and brown adipose tissue to efficiently take up long-chain fatty acids is key to their physiological functions in energy storage and thermogenesis, respectively. Several approaches have been taken to determine uptake rates by cultured cells and primary adipocytes including radio- and fluorescently labeled fatty acids. In ...
Khaneghah Amin Mousavi AM Department of Food Science and Technology, Islamic Azad University, Science and Research Branch, Tehran, - - 2013
PET containers for food oil packaging were evaluated with a newly established determination method for terephthalic acid (TPA) and isophthalic acid (IPA). The analysis of monomers, TPA and IPA that migrate from PET bottles into oils was performed by HPLC with a diode array detector (DAD). Three types of commercial ...
Müller Adrienne - - 2013
The concentrative amino acid transporter ATB(0,+) (SLC6A14) is under evaluation as a target for anticancer therapy. An ATB(0,+)-selective positron emission tomography (PET) probe could advance preclinical drug development. We characterised the cationic tyrosine analogue O-2((2-[(18)F]fluoroethyl)methyl-amino)ethyltyrosine ([(18)F]FEMAET) as a PET probe for ATB(0,+) activity. Cell uptake was studied in vitro. ATB(0,+) ...
Bhattacharya Sumangala - - 2013
Obesity and insulin resistance in skeletal muscles are major features of type 2 diabetes. In the present study, we examined the potential of Sambucus nigra flower (elderflowers) extracts to stimulate glucose uptake (GU) in primary porcine myotubes and reduce fat accumulation (FAc) in Caenorhabditis elegans. Bioassay guided chromatographic fractionations of ...
Bergmann R - - 2013
The bifunctional chelating agent 2-[4,7-bis(2-pyridylmethyl)-1,4,7-triazacyclononan-1-yl]acetic acid, DMPTACN-COOH, has been found to bind strongly to copper(II), resulting in a radiocopper(II)-ligand complex that exhibits high in vivo stability. The pendant carboxylic acid group enables this derivative to be conjugated to the N-terminal amino acid residues of peptides. Exploiting this, two stabilized bombesin (BBN) ...
Xu Su - - 2013
CD36 is a multifunctional protein that enhances cellular fatty acid (FA) uptake, a key step in energy metabolism, and its dysregulation in multiple tissue sites is central to obesity-linked diabetes, a risk factor for atherosclerosis. Although CD36 has been implicated in FA uptake in a correlative way, the molecular mechanisms ...
Claudie Dhuique-Mayer - - 2013
The health benefit of a diet rich in fruits and vegetables could be attributed to the presence of a large diversity of phytochemicals, including carotenoids. Bioactivities of carotenoids greatly depend on their bioavailability that could be modulated by the presence of other dietary constituents. Because citrus juices contain diverse antioxidant ...
Shang Xiuling - - 2013
Corynebacterium glutamicum is equipped with abundant membrane transporters to adapt to a changing environment. Many amino acid transporters have been identified in C. glutamicum, however, histidine uptake has not been investigated in detail. Here we identified the aromatic amino acid transporter encoded by aroP as a histidine transporter in C. ...
Sanandiya Naresh D - - 2013
A microwave assisted synthesis of a water soluble fluorogenic interpolymeric diamide has been described involving alginic acid and polyglucuronic acid (PGA) amide of ethylenediamine (EDA), through a monoamide of PGA and EDA, in good yields (>80wt% in each step). PGA was prepared by TEMPO (2,2,6,6-tetramethyl piperidine-1-oxyl radical) mediated oxidation of ...
Jensen Pernille R - - 2013
Uptake and upshot in vivo: Straightforward methods that permit the real-time observation of organic acid influx, intracellular acidification, and concomitant effects on cellular-reaction networks are crucial for improved bioprocess monitoring and control. Herein, dynamic nuclear polarization (DNP) NMR is used to observe acetate influx, ensuing intracellular acidification and the metabolic consequences ...
Peng Juanjuan - - 2013
Nanoparticles that circulate in the bloodstream for a prolonged period of time have important biomedicine applications. However, no example of lanthanide-based nanoparticles having a long-term circulation bloodstream has been reported to date. Herein, we report on difunctional radioactive and upconversion nanoparticles (UCNP) coated with polyphosphoric acid ligand, that is ethylenediamine ...
Barot Megha - - 2013
This work was aim to determine in vitro interaction of moxifloxacin with monocarboxylate transporter (MCT) using a human retinal pigment epithelium cells (ARPE-19). In vitro moxifloxacin uptakes were performed at 37°C across ARPE-19 cells. Concentration-dependent uptake of moxifloxacin was performed to delineate moxifloxacin kinetics with MCT. Effects of MCT substrates, ...
Ono Masahiro - - 2013
Positron emission tomography (PET) with amino acid tracers is useful for the visualization and assessment of therapeutic effects on gliomas. Our purpose is to elucidate the transport mechanisms of trans-1-amino-3-[(18)F]fluorocyclobutanecarboxylic acid (anti-[(18)F]FACBC) and l-[methyl-(11)C]methionine ([(11)C]Met) in normal human astrocytes (NHA), low-grade (Hs683, SW1088), and high-grade (U87MG, T98G) human glioma cell ...
Choung Sungwook - - 2013
Natural organic matter (NOM) plays an important role in determining the fate and transport of iodine species such as iodide (I-) and iodate (IO3-) in groundwater system. Although NOM exists as diverse forms in environments, prior iodine studies have mainly focused on uptake processes of iodide and iodate to humic ...
Mills Jeremy H - - 2013
Genetically encoded unnatural amino acids could facilitate the design of proteins and enzymes of novel function, but correctly specifying sites of incorporation, and the identities and orientations of surrounding residues represents a formidable challenge. Computational design methods have been used to identify optimal locations for functional sites in proteins and ...
Kim Sung Bong - - 2013
The fluorescence intensities (FIs) of raw and pretreated barley straws were measured by fluorescence microscopy, and the difference in the fluorescence intensity of barley straw before and after dilute acid pretreatment was analyzed by investigation of the major compounds of barley straw. The difference in fluorescence intensity was due to ...
Juge Narinobu - - 2013
Vesicular GABA transporter (VGAT) is expressed in GABAergic and glycinergic neurons, and is responsible for vesicular storage and subsequent exocytosis of these inhibitory amino acids. In the present study, we show that VGAT recognizes β-alanine as a substrate. Proteoliposomes containing purified VGAT transport β-alanine using Δψ but not ΔpH as ...
Sá-Pessoa Joana - - 2013
In this work we describe a new carboxylic acid transporter in Escherichia coli encoded by the gene yaaH. In contrast to what had been described for other YaaH family members, the E. coli transporter is highly specific for acetic acid (a monocarboxylate) and for succinic acid (a dicarboxylate), presenting the ...
Wang Qing - - 2013
A highly sensitive dynamic light scattering (DLS) assay for glucose detection without interference from ascorbic acid was demonstrated based on mercaptophenylboronic acid functionalized gold nanoparticles (MPBA-AuNPs). The stable, water-solubility MPBA-AuNPs were synthesized using facile and mild method. In the presence of glucose, specific binding between glucose and boronic acids resulted ...
Bacigalupi Celine - - 2013
Sensitivity to oxidation of an orange juice was investigated through packaging in standard PET or active PET with oxygen scavenger bottles. The evolution of dissolved oxygen was found to be similar in all bottles, whereas ascorbic acid degradation was related to the oxygen transfer with higher losses in standard PET ...
Wentzell Jeremy - - 2013
Gas-phase acids in light duty diesel (LDD) vehicle exhaust were measured using chemical ionization mass spectrometry (CIMS) and fuel based emission factors (EF) and NOx ratios for these species were determined under differing steady state engine operating conditions. The derived HONO and HNO3 EFs agree well with literature values, with ...
Zwartkruis Fried J T - - 2013
Oncogene-driven adaptation of metabolism during tumorigenesis includes steps that stimulate the uptake of nutrients, especially glucose and glutamine, to sustain cell growth and proliferation. Macropinocytosis, a clathrin- and caveolin-independent endocytotic process that had previously been linked to the action of oncogenic Ras and Src, is now shown to contribute to ...
Araújo João R - - 2013
The long-chain polyunsaturated fatty acids (LC-PUFAs) arachidonic (AA) and docosahexaenoic (DHA) acids are essential for fetal development. Gestational diabetes mellitus (GDM) is a pregnancy disorder associated with perinatal and lifelong risk complications for both the mother and the newborn. Our aim was to investigate the influence of GDM, and some ...
Usui Takuya - - 2013
The supply of L-carnosine, a bioactive dipeptide of β-alanine and L-histidine, to the retina across the blood-retinal barrier (BRB) was studied. The in vivo and in vitro studies revealed low uptake activities for [(3)H]Gly-Sar, a representative dipeptide, suggesting that L-carnosine transport plays only a minor role at the BRB. The ...
Zhou Lipeng - - 2013
Sulfonated hierarchical H-USY zeolite was prepared and characterized by X-ray diffraction, N2 physisorption, Fourier transform infrared spectroscopy, inductively coupled plasma atomic emission spectroscopy, temperature-programmed desorption of ammonia, and acid-base titration. It was proved that sulfonic group was successfully anchored onto the hierarchical H-USY zeolite. The acidity of the hierarchical H-USY ...
Smith Merry K - - 2013
The facile self-assembly of nanoscale boronate ester rectangles from linear bis-catechols and 1,4-benzene diboronic acid is described. Spectroscopic and computational analyses reveal the influence of extended π-conjugation on the rectangles' absorption and fluorescence properties. The rectangles represent a new class of discrete, organic soluble covalent organic polygons.
Ren Hong - - 2013
A novel, fast and simple method was developed to fabricate poly(acrylic acid sodium salt) microspheres (PAAS MSs). The resulting PAAS MSs were utilized as active templates to universally synthesize the mesoporous lanthanide-doped gadolinium oxide hollow nanospheres with multicolored upconversion emissions under mild conditions.
Ramabhadran Raghunath Ozhapakkam - - 2013
Computational challenges towards an accurate determination of the enthalpies of formation of amino acids are partly due to the non-availability of systematic error-cancelling thermochemical procedures for such biomonomers. Recently, we developed the Connectivity-Based Hierarchy (CBH) to accurately compute the enthalpies of formations of organic molecules composed of main group elements. ...
Okudaira Hiroyuki - - 2013
INTRODUCTION: Trans-1-amino-3-[(18)F]fluorocyclobutanecarboxylic acid (anti-[(18)F]FACBC) is a promising amino acid positron emission tomography (PET) radiotracer for visualizing prostate cancer. We previously showed that anti-FACBC is transported by amino acid transporters, especially by alanine-serine-cysteine transporter 2 (ASCT2), which is associated with tumor growth. We studied this affinity to assess the mechanism of ...
Mun Jiyoung - - 2013
2-Deoxy-2-[18F]fluoro-D-glucose (2-18FDG) has represented radiofluorinated carbohydrates as the most successful tracer for positron emission tomography (PET). 2-18FDG uptake depends on glucose metabolism, which is related to a disease progression. 2-18FDG has been widely used in oncology, neurology, cardiology, infectious diseases, and inflammation, to complement anatomical modalities such as CT and ...
Huang Chaofeng - - 2013
18F-labeled amino acids are an important class of imaging agents for positron emission tomography (PET) that target the increased rates of amino acid transport by many tumor cells. This class of tracers is structurally diverse, and the biological and imaging properties of a given 18F-labeled amino acid depends largely upon ...
Marín María J - - 2013
Photoinduced electron transfer (PET)-based molecular probes have been successfully used for the intracellular imaging of the pH of acidic organelles. In this study, we describe the synthesis and characterization of a novel PET-based pH nanoprobe and its biological application for the signaling of acidic organelles in mammalian cells. A fluorescent ...
Concepción Ramírez L - - 2013
Rhipicephalus (Boophilus) microplus is a tick that causes huge economic losses in cattle. The indiscriminate use of acaricides has generated resistance to most compounds present on the market. This makes further investigation on other potential acaricides necessary, the in silico assay being an alternative to the design of new compounds. ...
Yoshimoto Mitsuyoshi - - 2013
INTRODUCTION: 4-Borono-2-(18)F-fluoro-phenylalanine ((18)F-FBPA) has been used to anticipate the therapeutic effects of boron neutron capture therapy (BNCT) with 4-borono-L-phenylalanine (BPA). Similarly, L-[methyl-(11)C]-methionine ((11)C-MET), the most popular amino acid PET tracer, is a possible candidate for this purpose. We investigated the transport mechanism of (18)F-FBPA and compared it with that of ...
Akhtar Tariq A - - 2013
Silene latifolia is a dioecious plant that emits 1,2-dimethoxybenzene (veratrole), a potent pollinator attractant to the nocturnal moth, Hadena bicruris. Little is known about veratrole biosynthesis, although methylation of 2-methoxyphenol (guaiacol), another volatile emitted from S. latifolia flowers, has been proposed. Here we explore the biosynthetic route to veratrole. Feeding ...
Li Xingru - - 2013
The distribution and source of the solvent-extractable organic and inorganic components in PM2.5 (aerodynamics equivalent diameter below 2.5 microns), and PM10 (aerodynamics equivalent diameter below 10 microns) fractions of airborne particles were studied weekly from September 2006 to August 2007 in Beijing. The extracted organic and inorganic compounds identified in ...
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