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Varma Devika D Department of Biomedical Engineering, The City College of New York, New York, NY, United - - 2014
Disease, trauma, and aging all lead to deficits in soft tissue. As a result, there is the need to develop materials that safely and effectively restore areas of deficiency. While autogenous fat is the current gold standard, hyaluronic acid (HA) fillers are used commonly. However, the animal and bacterial origin ...
Keser Serhat S a Chemistry Department, Faculty of Science, Firat University , 23119 Elazig , - - 2014
Firethorn fruits have been used in traditional medicine owing to their diuretic, cardiac and tonic properties. In this study, the antiradical activities and phenolic, phytosterol, lipid-soluble vitamin and fatty acid contents of firethorn fruits were investigated. Antiradical activities of firethorn extracts (ethanol, water, methanol, acetone and diethyl ether) were determined ...
Abo Alrob Osama O *Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada, T6G - - 2014
CoA (coenzyme A) and its derivatives have a critical role in regulating cardiac energy metabolism. This includes a key role as a substrate and product in the energy metabolic pathways, as well as serving as an allosteric regulator of cardiac energy metabolism. In addition, the CoA ester malonyl-CoA has an ...
Endo Jin J Department of Health Chemistry, Graduate School of Pharmaceutical Sciences, the University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan Laboratory for Metabolomics, RIKEN Center for Integrative Medical Sciences (IMS), 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan Department of Cardiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, - - 2014
N-3 polyunsaturated fatty acids (PUFAs) have potential cardiovascular benefit, although the mechanisms underlying this effect remain poorly understood. Fat-1 transgenic mice expressing Caenorhabditis elegans n-3 fatty acid desaturase, which is capable of producing n-3 PUFAs from n-6 PUFAs, exhibited resistance to pressure overload-induced inflammation and fibrosis, as well as reduced ...
Lemaitre Rozenn N RN Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, United States. Electronic address: - - 2014
Prior studies suggest that circulating n-3 and trans-fatty acids influence the risk of sudden cardiac arrest (SCA). Yet, while other fatty acids also differ in their membrane properties and biological activities which may influence SCA, little is known about the associations of other circulating fatty acids with SCA. The aim ...
Chen Albert P AP GE Healthcare, Toronto, - - 2014
Hyperpolarized [1-(13) C]lactate in solution may be a clinically relevant and safe substrate for real time MR investigations of key metabolic pathways. The potential of using hyperpolarized [1-(13) C]lactate for magnetic resonance studies of cardiac metabolism in vivo was explored. Neat [1-(13) C]lactic acid was hyperpolarized using the dynamic nuclear ...
Barone Angela A Department of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, - - 2014
Although xenotransplantation of vascularized organs/cells has not yet reached the clinic, glutaraldehyde-treated bioprosthetic heart valves (BHV), derived from porcine or bovine tissues, are today used for clinical replacement of diseased heart valves. However, the durability of these valve cusps is limited partly due to the onset of immune responses to ...
Jones Meredyth M Food Animal Field Services, Department of Large Animal Clinical Sciences, College of Veterinary Medicine, Texas A&M University, 4475 TAMU, College Station, TX 77843, USA. Electronic address: - - 2014
Body water, electrolytes, and acid-base balance are important considerations in the evaluation and treatment of small ruminants and camelids with any disease process, with restoration of these a priority as adjunctive therapy. The goals of fluid therapy should be to maintain cardiac output and tissue perfusion, and to correct acid-base ...
Abo Alrob Osama O Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, - - 2014
Lysine acetylation is a novel post-translational pathway that regulates the activities of enzymes involved in both fatty acids and glucose metabolism. We examined whether lysine acetylation controls heart glucose and fatty acid oxidation in high fat diet (HFD) obese and SIRT3 KO mice. C57BL/6 mice were placed on either a ...
Jindal Akanksha A Isotope Applications & Radiopharmaceuticals Division, Bhabha Atomic Research Centre, Mumbai, 400085, - - 2014
While [(11) C]palmitate continues to be a promising tracer for cardiovascular Positron Emission Tomography (PET) imaging, unfavourable logistics due to the short half-life of (11) C (20 min) and cumbersome labeling methodologies are the major impediments that limit its widespread use. In order to circumvent such limitations, an attempt has been ...
Carubelli Valentina V Cardiology, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, - - 2014
Amino acids play a key role in multiple cellular processes. Amino acids availability is reduced in patients with heart failure (HF) with deleterious consequences on cardiac and whole-body metabolism. Several metabolic abnormalities have been identified in the failing heart, and many of them lead to an increased need of amino ...
Badavi Mohammad M Physiology Research Centre, Department of Physiology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran ; Atherosclerosis Research Center, Golestan Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR - - 2014
Myocardial infarction is one of the important causes of death during old ages. Gallic acid as an antioxidant or cyclosporine A (CsA) as inhibitor of mitochondrial permeability transition pore (mPTP) alone could prevent these complications to some extent, but their combination effect has not been investigated. The aim of this ...
Ussher John R JR Cardiovascular Research Centre, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, - - 2014
Obesity is a significant risk factor for the development of cardiovascular disease. Inhibiting fatty acid oxidation has emerged as a novel approach for the treatment of ischemic heart disease. Our aim was to determine whether pharmacologic inhibition of 3-ketoacyl-coenzyme A thiolase (3-KAT), which catalyzes the final step of fatty acid ...
Labbé Sébastien M SM 1Université de - - 2014
Using a novel positron emission tomography (PET) method with oral administration of 14(R,S)-[(18)F]-fluoro-6-thia-heptadecanoic acid ((18)FTHA), we recently demonstrated that subjects with impaired glucose tolerance (IGT) display an impairment in cardiac function associated with increased myocardial uptake of dietary fatty acids. Here, we determined whether modest weight loss induced by lifestyle ...
Tamariz Leonardo L Department of Medicine , Miller School of Medicine at the University of Miami, Miami, FL; Veterans Affairs Medical Center, Miami, FL. Electronic address: - - 2014
Atrial fibrillation (AF) is mediated by oxidative stress, neurohormonal and inflammatory activation. Serum uric acid (SUA) is a surrogate marker of oxidative stress. Xanthine oxidase (XO) produces SUA and is upregulated by inflammation and neurohormones. The purpose of this study was to perform a meta-analysis to evaluate the evidence supporting ...
Anderson Ethan J EJ East CarolinaUniversity, Pharmacology & Toxicology, BSOM 6S-10, 600 Moye Blvd., Greenville, North Carolina, United States, 27858 ; - - 2014
Studies in experimental models suggest n-3 polyunsaturated fatty acids (PUFAs) improve metabolic and anti-inflammatory/antioxidant capacity heart, although the mechanisms are unclear and translational evidence is lacking. In this study, patients ingested a moderately high dose of n-3 PUFAs (3.4 g/day eicosapentaneoic (EPA) and docosahexaneoic acid (DHA) ethyl-esters) for a period ...
Tsai Min-Shan MS The Department of Emergency Medicine, National Taiwan University Medical College and Hospital, Taipei, - - 2014
Intravenous (IV) administration of ascorbic acid during cardiopulmonary resuscitation (CPR) was reported to facilitate defibrillation and improves survival in ventricular fibrillation (VF) cardiac arrest. We investigated whether IV administration of ascorbic acid after return of spontaneous circulation (ROSC) can improve outcomes in VF cardiac arrest in a rat model and ...
Li Yanfei Y School of Life Sciences and Technology, Tongji University, Shanghai, China; Tongji University School of Medicine, Shanghai, - - 2014
Cardiac hypertrophy is an independent risk factor for cardiovascular disease and its subsequent progression to heart failure represents a major cause of morbidity and mortality in the world. CGA is an important component of chinese herbal medicine, acting as an antioxidant, scavenging free radicals and preventing inflammation. This study found ...
Kerner Janos J Case Western Reserve University, United - - 2014
Rat hearts were perfused with [1,2,3,4-(13)C4]palmitic acid (M+4), and the isotopic patterns of myocardial acylcarnitines and acyl-CoAs analyzed using UHPLC-MS/MS. The 91.2% (13)C-enrichment in palmitoylcarnitine shows that little endogenous (M+0) palmitate contributed to its formation. The presence of M+2 myristoylcarnitine (95.7%) and M+2 acetylcarnitine (19.4%) is evidence for β-oxidation of ...
Kimmel Alan R AR aLaboratory of Cellular and Developmental Biology (50/3351), National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland bThe Geriatric Research, Education and Clinical Center, Baltimore Veterans Affairs Healthcare Center, Division of Endocrinology, Department of Medicine, School of Medicine, University of Maryland, Baltimore, Maryland, - - 2014
We summarize recent mechanistic and physiological studies related to the role of perilipin 5 (Plin5) in regulating lipid droplet accumulation and protection to fatty acids in tissues with high lipid oxidative metabolism. Plin5 is a lipid droplet targeting protein that promotes association of lipid droplets with mitochondria and is most ...
Trent Chad M CM Columbia University Medical Center, United - - 2014
The rodent heart accumulates triglyceride and lipid droplets during fasting. The sources of heart lipids could be either free fatty acids liberated from adipose tissue or fatty acids from lipoprotein-associated triglyceride via the action of lipoprotein lipase (LpL). Because circulating levels of free fatty acids increase during fasting, it has ...
Gielen Marijke M 1Clinical Department and Laboratory of Intensive Care Medicine, Division of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium. 2Department of Anaesthesiology and Intensive Care, Karolinska University Hospital, Huddinge, Sweden. 3Department of Clinical Science Intervention and Technology, CLINTEC, Karolinska Institutet, Huddinge, - - 2014
Guidelines for administering amino acids to critically ill children are largely based on uncontrolled observational studies and expert opinion, without support from rigorous outcome studies. Also, data on circulating amino acid concentrations during critical illness are scarce. We thoroughly studied the time profiles of circulating amino acid concentrations in critically ...
Amara Issa E A IE Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada T6G - - 2014
Mercury exposure is associated with increased risk of cardiovascular disease and profound cardiotoxicity. However, the correlation between Hg(2+)-mediated toxicity and alteration in cardiac cytochrome P450s (Cyp) and their dependent arachidonic acid metabolites has never been investigated. Therefore, we investigated the effect of acute mercury toxicity on the expression of Cyp-epoxygenases ...
Siddesha Jalahalli M JM Research Service, Southeast Louisiana Veterans Health Care System, New Orleans, LA 70161; Heart and Vascular Institute, Tulane University School of Medicine, New Orleans, LA - - 2014
The omega-3 polyunsaturated fatty acids (ω-3 fatty acids) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have been reported to inhibit or delay the progression of cadiovascular diseases, including myocardial fibrosis. Recently we reported that angiotensin II (Ang II) promotes cardiac fibroblast (CF) migration by suppressing the MMP regulator reversion-inducing-cysteine-rich protein ...
Couturier Roland R aDépartement d'Anesthésie bLaboratoire d'Hémostase, Centre Chirurgical Marie Lannelongue, Le Plessis Robinson cService de Biologie Clinique, Hôpital Foch, Suresnes dLaboratoire de Pharmacologie, UPRES EA220, Hôpital Foch, Suresnes eLaboratoire de Pharmacologie - Toxicologie, Hôpital Raymond Poincaré, AP-HP, Garches, - - 2014
Tranexamic acid is given continuously or discontinuously as an anti-fibrinolytic therapy during cardiac surgery, but the effects on fibrinolysis parameters remain poorly investigated. We sought to assess the effects of continuous and discontinuous tranexamic acid on fibrinolysis parameters in children undergoing cardiac surgery with cardiopulmonary bypass (CPB). Children requiring cardiac ...
Gallyamov Marat O MO Faculty of Physics, Lomonosov Moscow State University, Leninskie gory 1-2, Moscow 119991, Russian Federation; Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, Vavilova 28, Moscow 119991, Russian Federation. Electronic address: - - 2014
Calcification of bovine pericardium dramatically shortens typical lifetimes of biological prosthetic heart valves and thus precludes their choice for younger patients. The aim of the present work is to demonstrate that the calcification is to be mitigated by means of treatment of bovine pericardium in solutions of chitosan in carbonic ...
Djoussé Luc L Division of Aging, Brigham and Women's Hospital, 1620 Tremont St. 3rd Floor, Boston, MA, 02120, USA, - - 2014
Studies have previously examined the relation between a single measure of plasma fatty acids and risk of heart failure. However, it is unclear whether the use of repeated measures of fatty acids over time is required for the assessment of omega-3 fatty acids heart failure relation. Using a nested case-control ...
Fezeu Léopold K LK Université Paris 13, Sorbonne Paris Cité - Equipe de Recherche en Epidémiologie Nutritionnelle (EREN), Centre d'Epidémiologie et Biostatistiques (EPIBIOS), Inserm, Inra, Cnam, Université Paris 5, Université Paris 7, Bobigny, - - 2014
We aimed to investigate the association between baseline plasma fatty acids profile and the risk of future major cardiovascular events in patients with a history of ischaemic heart disease or ischemic stroke. Baseline plasma fatty acids as well as established cardiovascular risk factors were measured in 2,263 patients enrolled in ...
Goo Soyeon S Auckland Bioengineering Institute, The University of Auckland, Auckland, New - - 2014
Abstract It is generally recognized that increased consumption of polyunsaturated fatty acids, fish oil (FO) in particular, is beneficial to cardiac and cardiovascular health, whereas equivalent consumption of saturated fats is deleterious. In this study, we explore this divergence, adopting a limited purview: The effect of dietary fatty acids on ...
Ristagno Giuseppe G IRCCS - Istituto di Ricerche Farmacologiche "Mario Negri", Milan, Italy (G.R., R.L., S.M., J.L., C.F., G.G., S.B., - - 2014
The kynurenine pathway (KP) is the major route of tryptophan (TRP) catabolism and is activated by inflammation and after cardiac arrest in animals. We hypothesized that the KP activation level correlates with severity of post-cardiac arrest shock, early death, and long-term outcome. Plasma was obtained from 245 patients enrolled in ...
Kromhout Daan D Division of Human Nutrition, Wageningen University, Wageningen, The - - 2013
The fish fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) may promote cardiometabolic health. This review summarizes the results of recent meta-analyses of prospective studies on cardiovascular diseases, diabetes type 2 and markers of atherosclerosis and thrombosis. The results of recently published meta-analyses of prospective cohort studies showed that ...
Zhang Liyan - - 2013
Plasma fatty acids levels are markedly elevated in patients with myocardial ischemic-reperfusion injury including those after cardiopulmonary bypass (CPB). High levels of fatty acids have detrimental effects on myocardial function. Extracorporeal membrane oxygenation (ECMO) is like CPB, but much longer, to provide a life-saving support for patients with cardiac arrest. ...
Hoffmann Lars - - 2013
Patients with inborn errors of long-chain fatty acid oxidation accumulate disease-specific acylcarnitines and triacylglycerols in various tissues. Some of these patients present significant cardiac diseases such as arrhythmias and cardiomyopathy. The mechanism of how fatty acid accumulation is involved in disease pathogenesis is still unclear but apoptosis of cardiomyocytes has ...
Zeng Huahui H Key Laboratory of Radiopharmaceuticals of Ministry of Education, College of Chemistry, Beijing Normal University, Beijing 100875, China; Department of Nuclear Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, China. Electronic address: - - 2013
Four (99m)Tc-labeled fatty acid analogs, 1b, 2b, 3b, 4b were synthesized by a double ligand transfer reaction and theirs potential were investigated. The radiochemical yield of the radiotracers was from 11.7% to 30.3% (no decay corrected). Those compounds were found to be chemically stable when incubated in SD rat serum ...
Biet Michael - - 2013
Clinical and animal studies indicate that increased fatty acid delivery to lean tissues induce cardiac electrical remodeling and alterations of cellular calcium homeostasis. Since this may represent a mechanisms initiating cardiac dysfunction during establishment of insulin resistance and diabetes or anaerobic cardiac metabolism (ischemia), we sought to determine if short ...
Kates Steven A - - 2013
Lipoic acid (1,2-dithiolane-3-pentanoic acid) is a pharmacophore with unique antioxidant and cytoprotective properties. We synthesized a library based upon the condensation of natural and unnatural amino acids with the carboxylic acid moiety of lipoic acid. SAR studies were conducted using a cardiac ischemia-reperfusion animal model. Cytoprotective efficacy was associated with ...
Cicero Arrigo Francesco Giuseppe - - 2013
Serum uric acid is representative for xanthine-oxidase, the key enzyme involved in the production of uric acid, which is up-regulated in the failing heart, and may play an important role in the pathophysiologic process that leads to heart failure. In our study, we investigated the relation between stroke volume, cardiac ...
He Quan - - 2013
Cardiolipin, a signature phospholipid of mitochondria, is predominantly present in the mitochondrial inner membrane and plays an important role in keeping optimal mitochondrial function. In addition to the cardiolipin content, the composition of four fatty acid chain is thought determine cardiolipin biological function. These acyl chains of cardiolipin are dynamically ...
DiNicolantonio James J JJ Mid America Heart Institute, Saint Luke's Hospital, Kansas City, USA. - - 2013
Multiple trials over the past two decades testing omega-3 polyunsaturated fatty acids (PUFAs), containing eicosapentaenoic acid (EPA) and or docosahexaenoic acid (DHA), have shown substantial benefits for reducing major coronary heart disease (CHD) events, all-cause mortality, cardiovascular (CV) death, sudden cardiac death (SCD), and stroke. However, recent trials testing omega-3s ...
Metcalf R G - - 2013
Background/objectives:Randomised controlled trials (RCTs) evaluating the effect of fish oil supplementation on postoperative atrial fibrillation (POAF) following cardiac surgery have produced mixed results. In this study, we examined relationships between levels of red blood cell (RBC) n-3 long-chain polyunsaturated fatty acids (LC-PUFAs) and the incidence of POAF.Subjects/methods:We used combined data ...
Fillmore N - - 2013
Heart disease is a leading cause of death worldwide. In many forms of heart disease, including heart failure, ischemic heart disease and diabetic cardiomyopathies, changes in cardiac mitochondrial energy metabolism contribute to contractile dysfunction and to a decrease in cardiac efficiency. Specific metabolic changes include a relative increase in cardiac ...
Reinders I - - 2013
BACKGROUND/OBJECTIVES:Lower circulating polyunsaturated fatty acids (PUFAs) may induce loss of heart function. We investigated whether lower concentrations of n-3 and n-6 PUFAs were associated with less favourable echocardiographic measures and higher heart rate in older Caucasians, cross-sectionally and after 7 years of follow-up.SUBJECTS/METHODS:We used data from the Hoorn Study, a ...
Solak Yalcin Y Nephrology Unit, Department of Internal Medicine, Karaman State Hospital, Karaman, - - 2014
Erectile dysfunction (ED) is a frequent complaint of elderly subjects and is closely associated with endothelial dysfunction and cardiovascular disease (CVD). Uric acid is also associated with endothelial dysfunction, oxidative stress, and CVD, raising the hypothesis that an increased serum uric acid might predict ED in patients who are at ...
el Azzouzi Hamid H Department of Cardiology, CARIM School for Cardiovascular Diseases, Maastricht University, 6229 ER Maastricht, the Netherlands; Department of Cardiology, University Medical Center Utrecht, 3584 CX Utrecht, the - - 2013
Peroxisome proliferator-activated receptor δ (PPARδ) is a critical regulator of energy metabolism in the heart. Here, we propose a mechanism that integrates two deleterious characteristics of heart failure, hypoxia and a metabolic shift toward glycolysis, involving the microRNA cluster miR-199a∼214 and PPARδ. We demonstrate that under hemodynamic stress, cardiac hypoxia ...
Erenler Ali Kemal AK Department of Emergency Medicine, Hitit University, Corum Education and Research Hospital, - - 2013
The early diagnosis of many diseases is critical, especially in the Emergency Department. Biochemical markers can be helpful for emergency physicians in these critical situations. Heart-type fatty acid binding protein (H-FABP) is one of the promising plasma markers for the detection of tissue injury. H-FABP is known to be released ...
Iso Tatsuya T From the Department of Medicine and Biological Science (T.I., T.S., K.G., M.R.A.AS., H.M., M.A., M.K.), Education and Research Support Center (T.I., M.K.), Department of Bioimaging Information Analysis (H.H., A.Y.), and Department of Diagnostic Radiology and Nuclear Medicine (K.E.), Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan; Department of Genetics and Complex Diseases and Nutrition, Broad Institute of Harvard and MIT, Harvard School of Public Health, Boston, MA (K.M., G.S.H.); Department of Biochemistry (T.H., Y.N., M.S.), JST, ERATO, Suematsu Gas Biology Project (T.H., Y.N., M.S.), and Department of Cardiology (M.S.), Keio University School of Medicine, Tokyo, Japan; and Department of Medicine, Center for Human Nutrition, Washington University School of Medicine, St. Louis, MO (N.A.A.). Current address for K.M.: Department of Complementary and Alternative Medicine, Graduate School of Medicine, Osaka University Hospital, Osaka, Japan. Current address for H.H.: Department of Molecular Imaging and Radiotherapy, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, - - 2013
Fatty acids (FAs) are the major substrate for energy production in the heart. Here, we hypothesize that capillary endothelial fatty acid binding protein 4 (FABP4) and FABP5 play an important role in providing sufficient FAs to the myocardium. Both FABP4/5 were abundantly expressed in capillary endothelium in the heart and ...
Marangoni Franca - - 2013
A high dietary intake of n-3 long chain polyunsaturated fatty acids (PUFA), eicosapentaenoic and docosahexaenoic acids, is associated with a reduced incidence of coronary events. Supplementation with pharmacological doses of the same may improve survival in patients with previous myocardial infarction and established heart failure. Such protective effects may be ...
Monaco Julie - - 2013
Probably not. A new meta-analysis adds to a growing body of evidence that omega-3 fatty acids do little to protect against heart disease.
Brunetti Marissa A - - 2013
Objective: To determine whether blood levels of the brain-specific biomarker glial fibrillary acidic protein rise during cardiopulmonary bypass for repair of congenital heart disease. Methods: This is a prospective observational pilot study to characterise the blood levels of glial fibrillary acidic protein during bypass. Children <21 years of age undergoing ...
Rupp Thomas P - - 2013
Objectives: To explore the rationale for ω-3 fatty acids in heart failure treatment, the dosage of EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid) for replacing low levels of highly unsaturated fatty acids (HUFA deficiency) was examined. To judge the usefulness of various EPA/DHA preparations, their content of peroxides and aldehydes ...
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