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Tamariz Leonardo L Department of Medicine , Miller School of Medicine at the University of Miami, Miami, FL; Veterans Affairs Medical Center, Miami, FL. Electronic address: - - 2014
Atrial fibrillation (AF) is mediated by oxidative stress, neurohormonal and inflammatory activation. Serum uric acid (SUA) is a surrogate marker of oxidative stress. Xanthine oxidase (XO) produces SUA and is upregulated by inflammation and neurohormones. The purpose of this study was to perform a meta-analysis to evaluate the evidence supporting ...
Anderson Ethan J EJ East CarolinaUniversity, Pharmacology & Toxicology, BSOM 6S-10, 600 Moye Blvd., Greenville, North Carolina, United States, 27858 ; - - 2014
Studies in experimental models suggest n-3 polyunsaturated fatty acids (PUFAs) improve metabolic and anti-inflammatory/antioxidant capacity heart, although the mechanisms are unclear and translational evidence is lacking. In this study, patients ingested a moderately high dose of n-3 PUFAs (3.4 g/day eicosapentaneoic (EPA) and docosahexaneoic acid (DHA) ethyl-esters) for a period ...
Tsai Min-Shan MS The Department of Emergency Medicine, National Taiwan University Medical College and Hospital, Taipei, - - 2014
Intravenous (IV) administration of ascorbic acid during cardiopulmonary resuscitation (CPR) was reported to facilitate defibrillation and improves survival in ventricular fibrillation (VF) cardiac arrest. We investigated whether IV administration of ascorbic acid after return of spontaneous circulation (ROSC) can improve outcomes in VF cardiac arrest in a rat model and ...
Li Yanfei Y School of Life Sciences and Technology, Tongji University, Shanghai, China; Tongji University School of Medicine, Shanghai, - - 2014
Cardiac hypertrophy is an independent risk factor for cardiovascular disease and its subsequent progression to heart failure represents a major cause of morbidity and mortality in the world. CGA is an important component of chinese herbal medicine, acting as an antioxidant, scavenging free radicals and preventing inflammation. This study found ...
Kerner Janos J Case Western Reserve University, United - - 2014
Rat hearts were perfused with [1,2,3,4-(13)C4]palmitic acid (M+4), and the isotopic patterns of myocardial acylcarnitines and acyl-CoAs analyzed using UHPLC-MS/MS. The 91.2% (13)C-enrichment in palmitoylcarnitine shows that little endogenous (M+0) palmitate contributed to its formation. The presence of M+2 myristoylcarnitine (95.7%) and M+2 acetylcarnitine (19.4%) is evidence for β-oxidation of ...
Kimmel Alan R AR aLaboratory of Cellular and Developmental Biology (50/3351), National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland bThe Geriatric Research, Education and Clinical Center, Baltimore Veterans Affairs Healthcare Center, Division of Endocrinology, Department of Medicine, School of Medicine, University of Maryland, Baltimore, Maryland, - - 2014
We summarize recent mechanistic and physiological studies related to the role of perilipin 5 (Plin5) in regulating lipid droplet accumulation and protection to fatty acids in tissues with high lipid oxidative metabolism. Plin5 is a lipid droplet targeting protein that promotes association of lipid droplets with mitochondria and is most ...
Trent Chad M CM Columbia University Medical Center, United - - 2014
The rodent heart accumulates triglyceride and lipid droplets during fasting. The sources of heart lipids could be either free fatty acids liberated from adipose tissue or fatty acids from lipoprotein-associated triglyceride via the action of lipoprotein lipase (LpL). Because circulating levels of free fatty acids increase during fasting, it has ...
Gielen Marijke M 1Clinical Department and Laboratory of Intensive Care Medicine, Division of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium. 2Department of Anaesthesiology and Intensive Care, Karolinska University Hospital, Huddinge, Sweden. 3Department of Clinical Science Intervention and Technology, CLINTEC, Karolinska Institutet, Huddinge, - - 2014
Guidelines for administering amino acids to critically ill children are largely based on uncontrolled observational studies and expert opinion, without support from rigorous outcome studies. Also, data on circulating amino acid concentrations during critical illness are scarce. We thoroughly studied the time profiles of circulating amino acid concentrations in critically ...
Amara Issa E A IE Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada T6G - - 2014
Mercury exposure is associated with increased risk of cardiovascular disease and profound cardiotoxicity. However, the correlation between Hg(2+)-mediated toxicity and alteration in cardiac cytochrome P450s (Cyp) and their dependent arachidonic acid metabolites has never been investigated. Therefore, we investigated the effect of acute mercury toxicity on the expression of Cyp-epoxygenases ...
Siddesha Jalahalli M JM Research Service, Southeast Louisiana Veterans Health Care System, New Orleans, LA 70161; Heart and Vascular Institute, Tulane University School of Medicine, New Orleans, LA - - 2014
The omega-3 polyunsaturated fatty acids (ω-3 fatty acids) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have been reported to inhibit or delay the progression of cadiovascular diseases, including myocardial fibrosis. Recently we reported that angiotensin II (Ang II) promotes cardiac fibroblast (CF) migration by suppressing the MMP regulator reversion-inducing-cysteine-rich protein ...
Couturier Roland R aDépartement d'Anesthésie bLaboratoire d'Hémostase, Centre Chirurgical Marie Lannelongue, Le Plessis Robinson cService de Biologie Clinique, Hôpital Foch, Suresnes dLaboratoire de Pharmacologie, UPRES EA220, Hôpital Foch, Suresnes eLaboratoire de Pharmacologie - Toxicologie, Hôpital Raymond Poincaré, AP-HP, Garches, - - 2014
Tranexamic acid is given continuously or discontinuously as an anti-fibrinolytic therapy during cardiac surgery, but the effects on fibrinolysis parameters remain poorly investigated. We sought to assess the effects of continuous and discontinuous tranexamic acid on fibrinolysis parameters in children undergoing cardiac surgery with cardiopulmonary bypass (CPB). Children requiring cardiac ...
Gallyamov Marat O MO Faculty of Physics, Lomonosov Moscow State University, Leninskie gory 1-2, Moscow 119991, Russian Federation; Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, Vavilova 28, Moscow 119991, Russian Federation. Electronic address: - - 2014
Calcification of bovine pericardium dramatically shortens typical lifetimes of biological prosthetic heart valves and thus precludes their choice for younger patients. The aim of the present work is to demonstrate that the calcification is to be mitigated by means of treatment of bovine pericardium in solutions of chitosan in carbonic ...
Djoussé Luc L Division of Aging, Brigham and Women's Hospital, 1620 Tremont St. 3rd Floor, Boston, MA, 02120, USA, - - 2014
Studies have previously examined the relation between a single measure of plasma fatty acids and risk of heart failure. However, it is unclear whether the use of repeated measures of fatty acids over time is required for the assessment of omega-3 fatty acids heart failure relation. Using a nested case-control ...
Fezeu Léopold K LK Université Paris 13, Sorbonne Paris Cité - Equipe de Recherche en Epidémiologie Nutritionnelle (EREN), Centre d'Epidémiologie et Biostatistiques (EPIBIOS), Inserm, Inra, Cnam, Université Paris 5, Université Paris 7, Bobigny, - - 2014
We aimed to investigate the association between baseline plasma fatty acids profile and the risk of future major cardiovascular events in patients with a history of ischaemic heart disease or ischemic stroke. Baseline plasma fatty acids as well as established cardiovascular risk factors were measured in 2,263 patients enrolled in ...
Kromhout Daan D Division of Human Nutrition, Wageningen University, Wageningen, The - - 2013
The fish fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) may promote cardiometabolic health. This review summarizes the results of recent meta-analyses of prospective studies on cardiovascular diseases, diabetes type 2 and markers of atherosclerosis and thrombosis. The results of recently published meta-analyses of prospective cohort studies showed that ...
Zhang Liyan - - 2013
Plasma fatty acids levels are markedly elevated in patients with myocardial ischemic-reperfusion injury including those after cardiopulmonary bypass (CPB). High levels of fatty acids have detrimental effects on myocardial function. Extracorporeal membrane oxygenation (ECMO) is like CPB, but much longer, to provide a life-saving support for patients with cardiac arrest. ...
Hoffmann Lars - - 2013
Patients with inborn errors of long-chain fatty acid oxidation accumulate disease-specific acylcarnitines and triacylglycerols in various tissues. Some of these patients present significant cardiac diseases such as arrhythmias and cardiomyopathy. The mechanism of how fatty acid accumulation is involved in disease pathogenesis is still unclear but apoptosis of cardiomyocytes has ...
Zeng Huahui H Key Laboratory of Radiopharmaceuticals of Ministry of Education, College of Chemistry, Beijing Normal University, Beijing 100875, China; Department of Nuclear Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, China. Electronic address: - - 2013
Four (99m)Tc-labeled fatty acid analogs, 1b, 2b, 3b, 4b were synthesized by a double ligand transfer reaction and theirs potential were investigated. The radiochemical yield of the radiotracers was from 11.7% to 30.3% (no decay corrected). Those compounds were found to be chemically stable when incubated in SD rat serum ...
Biet Michael - - 2013
Clinical and animal studies indicate that increased fatty acid delivery to lean tissues induce cardiac electrical remodeling and alterations of cellular calcium homeostasis. Since this may represent a mechanisms initiating cardiac dysfunction during establishment of insulin resistance and diabetes or anaerobic cardiac metabolism (ischemia), we sought to determine if short ...
Kates Steven A - - 2013
Lipoic acid (1,2-dithiolane-3-pentanoic acid) is a pharmacophore with unique antioxidant and cytoprotective properties. We synthesized a library based upon the condensation of natural and unnatural amino acids with the carboxylic acid moiety of lipoic acid. SAR studies were conducted using a cardiac ischemia-reperfusion animal model. Cytoprotective efficacy was associated with ...
Cicero Arrigo Francesco Giuseppe - - 2013
Serum uric acid is representative for xanthine-oxidase, the key enzyme involved in the production of uric acid, which is up-regulated in the failing heart, and may play an important role in the pathophysiologic process that leads to heart failure. In our study, we investigated the relation between stroke volume, cardiac ...
He Quan - - 2013
Cardiolipin, a signature phospholipid of mitochondria, is predominantly present in the mitochondrial inner membrane and plays an important role in keeping optimal mitochondrial function. In addition to the cardiolipin content, the composition of four fatty acid chain is thought determine cardiolipin biological function. These acyl chains of cardiolipin are dynamically ...
DiNicolantonio James J JJ Mid America Heart Institute, Saint Luke's Hospital, Kansas City, USA. - - 2013
Multiple trials over the past two decades testing omega-3 polyunsaturated fatty acids (PUFAs), containing eicosapentaenoic acid (EPA) and or docosahexaenoic acid (DHA), have shown substantial benefits for reducing major coronary heart disease (CHD) events, all-cause mortality, cardiovascular (CV) death, sudden cardiac death (SCD), and stroke. However, recent trials testing omega-3s ...
Metcalf R G - - 2013
Background/objectives:Randomised controlled trials (RCTs) evaluating the effect of fish oil supplementation on postoperative atrial fibrillation (POAF) following cardiac surgery have produced mixed results. In this study, we examined relationships between levels of red blood cell (RBC) n-3 long-chain polyunsaturated fatty acids (LC-PUFAs) and the incidence of POAF.Subjects/methods:We used combined data ...
Fillmore N - - 2013
Heart disease is a leading cause of death worldwide. In many forms of heart disease, including heart failure, ischemic heart disease and diabetic cardiomyopathies, changes in cardiac mitochondrial energy metabolism contribute to contractile dysfunction and to a decrease in cardiac efficiency. Specific metabolic changes include a relative increase in cardiac ...
Reinders I - - 2013
BACKGROUND/OBJECTIVES:Lower circulating polyunsaturated fatty acids (PUFAs) may induce loss of heart function. We investigated whether lower concentrations of n-3 and n-6 PUFAs were associated with less favourable echocardiographic measures and higher heart rate in older Caucasians, cross-sectionally and after 7 years of follow-up.SUBJECTS/METHODS:We used data from the Hoorn Study, a ...
Solak Yalcin Y Nephrology Unit, Department of Internal Medicine, Karaman State Hospital, Karaman, - - 2014
Erectile dysfunction (ED) is a frequent complaint of elderly subjects and is closely associated with endothelial dysfunction and cardiovascular disease (CVD). Uric acid is also associated with endothelial dysfunction, oxidative stress, and CVD, raising the hypothesis that an increased serum uric acid might predict ED in patients who are at ...
El Azzouzi Hamid - - 2013
Peroxisome proliferator-activated receptor δ (PPARδ) is a critical regulator of energy metabolism in the heart. Here, we propose a mechanism that integrates two deleterious characteristics of heart failure, hypoxia and a metabolic shift toward glycolysis, involving the microRNA cluster miR-199a∼214 and PPARδ. We demonstrate that under hemodynamic stress, cardiac hypoxia ...
Erenler Ali Kemal AK Department of Emergency Medicine, Hitit University, Corum Education and Research Hospital, - - 2013
The early diagnosis of many diseases is critical, especially in the Emergency Department. Biochemical markers can be helpful for emergency physicians in these critical situations. Heart-type fatty acid binding protein (H-FABP) is one of the promising plasma markers for the detection of tissue injury. H-FABP is known to be released ...
Iso Tatsuya T From the Department of Medicine and Biological Science (T.I., T.S., K.G., M.R.A.AS., H.M., M.A., M.K.), Education and Research Support Center (T.I., M.K.), Department of Bioimaging Information Analysis (H.H., A.Y.), and Department of Diagnostic Radiology and Nuclear Medicine (K.E.), Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan; Department of Genetics and Complex Diseases and Nutrition, Broad Institute of Harvard and MIT, Harvard School of Public Health, Boston, MA (K.M., G.S.H.); Department of Biochemistry (T.H., Y.N., M.S.), JST, ERATO, Suematsu Gas Biology Project (T.H., Y.N., M.S.), and Department of Cardiology (M.S.), Keio University School of Medicine, Tokyo, Japan; and Department of Medicine, Center for Human Nutrition, Washington University School of Medicine, St. Louis, MO (N.A.A.). Current address for K.M.: Department of Complementary and Alternative Medicine, Graduate School of Medicine, Osaka University Hospital, Osaka, Japan. Current address for H.H.: Department of Molecular Imaging and Radiotherapy, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, - - 2013
Fatty acids (FAs) are the major substrate for energy production in the heart. Here, we hypothesize that capillary endothelial fatty acid binding protein 4 (FABP4) and FABP5 play an important role in providing sufficient FAs to the myocardium. Both FABP4/5 were abundantly expressed in capillary endothelium in the heart and ...
Marangoni Franca - - 2013
A high dietary intake of n-3 long chain polyunsaturated fatty acids (PUFA), eicosapentaenoic and docosahexaenoic acids, is associated with a reduced incidence of coronary events. Supplementation with pharmacological doses of the same may improve survival in patients with previous myocardial infarction and established heart failure. Such protective effects may be ...
Monaco Julie - - 2013
Probably not. A new meta-analysis adds to a growing body of evidence that omega-3 fatty acids do little to protect against heart disease.
Brunetti Marissa A - - 2013
Objective: To determine whether blood levels of the brain-specific biomarker glial fibrillary acidic protein rise during cardiopulmonary bypass for repair of congenital heart disease. Methods: This is a prospective observational pilot study to characterise the blood levels of glial fibrillary acidic protein during bypass. Children <21 years of age undergoing ...
Rupp Thomas P - - 2013
Objectives: To explore the rationale for ω-3 fatty acids in heart failure treatment, the dosage of EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid) for replacing low levels of highly unsaturated fatty acids (HUFA deficiency) was examined. To judge the usefulness of various EPA/DHA preparations, their content of peroxides and aldehydes ...
Teta Daniel - - 2013
Friedman et al. report that hemodialysis patients with the highest levels of n-3 fatty acids had impressively low odds of sudden cardiac death. The study is limited by a small sample size, and the analysis relies on only a single baseline measurement of blood levels. Recent randomized evidence indeed fails ...
Kruse Leslie G - - 2013
Omega-3 polyunsaturated fatty acids (PUFA's) have an FDA indication for triglyceride lowering in patients with hypertriglyceridemia. Some European agencies have also approved omega-3 fatty acids for cardiovascular risk modification. Several major societies in the US also recommend their use following myocardial infarction. The purpose of this review was to assimilate ...
Peter Soumia - - 2013
Dyslipidemia and its consequences are emerging as epidemics with deleterious consequences on cardiovascular (CV) health. The beneficial effects of omega-3-fatty acids on cardiac and extra cardiac organs have been extensively studied in the last two decades, and continue to show great promise in the primary and secondary prevention of cardiovascular ...
Zhu Yi - - 2013
Mechanistic target of rapamycin (mTOR) is essential for cardiac development, growth and function, but the role of mTOR in the regulation of cardiac metabolism and mitochondrial respiration is not well established. This study sought to determine cardiac metabolism and mitochondrial bioenergetics in mice with inducible deletion of mTOR in the ...
Kumar Saurabh - - 2013
BACKGROUND: Intravenous omega-3 polyunsaturated fatty acids (ω-3 PUFAs) may prevent atrial fibrillation (AF) inducibility and perpetuation in animal models. We examined the effect of high dose IV ω-3 PUFAs on human atrial electrophysiology. METHODS AND RESULTS: We randomised 88 patients with no structural heart disease to receive saline (control group) ...
Speers-Roesch Ben - - 2013
The ability to maintain stable cardiac function during environmental hypoxia exposure is crucial for hypoxia tolerance in animals and depends upon the maintenance of cardiac energy balance as well as the state of the heart's extracellular environment (e.g., availability of metabolic fuels). Hypoxic depression of plasma [non-esterified fatty acids] (NEFA), ...
Liepinsh Edgars - - 2013
Depressed oxidation of long chain fatty acids (LCFA) in heart ischemia leads to acute accumulation of LCFA metabolites that impair the functioning of the mitochondria. We hypothesized that reduced activity of carnitine palmitoyltransferase-I (CPT-I) might activate peroxisomal LCFA oxidation and protect mitochondrial function in ischemia and reperfusion. In the present ...
Drosatos Konstantinos - - 2013
Diabetes and obesity are both associated with lipotoxic cardiomyopathy exclusive of coronary artery disease and hypertension. Lipotoxicities have become a public health concern and are responsible for a significant portion of clinical cardiac disease. These abnormalities may be the result of a toxic metabolic shift to more fatty acid and ...
Gregory M K - - 2013
Young and healthy broilers are susceptible to sudden death syndrome (SDS), which is caused by cardiac arrhythmia. The long-chain 'fish-type' omega-3 fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), have cardioprotective anti-arrhythmic effects in animals and humans. Raising the cardiac level of EPA and DHA in chickens may protect ...
Bozcali Evin - - 2013
OBJECTIVE: We conducted a clinical trial to examine the effect of ω-3 fatty acids in patients with cardiac syndrome X (CSX). We aimed to evaluate the potential impact of ω-3 fatty acids on endothelial function, oxidative stress, and symptom relief in the CSX. METHODS AND RESULTS: Eighteen patients with CSX ...
Friedman Allon N AN Division of Nephrology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA. - - 2013
Experimental and clinical evidence suggests that long-chain n-3 fatty acids may protect against sudden cardiac death, the leading cause of mortality in hemodialysis patients. Here we investigated whether long-chain n-3 fatty acids have a protective relationship with sudden cardiac death in 100 patients who died of sudden cardiac death during ...
Lin Ming-Cheng - - 2013
Preventive effects of ellagic acid against doxorubicin-induced cardiac oxidative, inflammatory and apoptotic stress were examined. This agent at 0.25, 0.5 or 1 % was added in feed and supplied to mice for 8 weeks, and followed by doxorubicin treatment. Ellagic acid intake increased its deposit in heart. Pre-intake of this compound at ...
Poudyal Hemant - - 2013
The n-3 polyunsaturated fatty acids (PUFA) have been proposed as potential treatments for human heart failure. The cardioprotective effects of n-3 PUFA are supported by extensive cell culture, animal and human studies. Animal studies with n-3 PUFA have shown marked improvements in many independent risk factors for heart failure, including ...
Singh Krishna K - - 2013
OBJECTIVE: Alterations in cardiac energy and substrate metabolism play a critical role in the development and clinical course of heart failure. We hypothesized that the cardioprotective role of the breast cancer 1, early onset (BRCA1) gene might be mediated in part by alterations in cardiac bioenergetics. METHODS: We generated cardiomyocyte-specific ...
Wu Jason H Y - - 2013
Long-chain polyunsaturated omega-3 fatty acids (n-3 PUFA) demonstrated antiarrhythmic potential in experimental studies. In a large multinational randomized trial (OPERA), perioperative fish oil supplementation did not reduce the risk of postoperative atrial fibrillation (PoAF) in cardiac surgery patients. However, whether presupplementation habitual plasma phospholipid n-3 PUFA, or achieved or change ...
Heger Zbynek - - 2013
Doxorubicin is a commonly used antineoplastic agent in the treatment of many types of cancer. Little is known about the interactions of doxorubicin with cardiac biomolecules. Serious cardiotoxicity including dilated cardiomyopathy often resulting in a fatal congestive heart failure may occur as a consequence of chemotherapy with doxorubicin. The purpose ...
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