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Czeizel Andrew E - - 2013
Diet, particularly vitamin deficiency, is associated with the risk of birth defects. The aim of this review paper is to show the characteristics of common and severe neural-tube defects together with congenital heart defects (CHD) as vitamin deficiencies play a role in their origin. The findings of the Hungarian intervention ...
Din Jehangir N JN Centre for Cardiovascular Sciences, University of Edinburgh, Edinburgh, - - 2013
The mechanisms through which ω-3 fatty acids reduce adverse cardiac events remain uncertain. We aimed to investigate the effect of ω-3 fatty acid supplementation on endothelial vasomotor function, endogenous fibrinolysis, and platelet and monocyte activation in patients with coronary heart disease. Randomised, double-blind, placebo-controlled, cross-over trial. Academic cardiac centre. 20 ...
Giroud Sylvain S Research Institute of Wildlife Ecology, Department of Integrative Biology and Evolution, University of Veterinary Medicine, Vienna, Austria. - - 2013
Polyunsaturated fatty acids (PUFA) have strong effects on hibernation and daily torpor. Increased dietary uptake of PUFA of the n-6 class, particularly of Linoleic acid (LA, C18:2 n-6) lengthens torpor bout duration and enables animals to reach lower body temperatures (T(b)) and metabolic rates. As previously hypothesized, this well-known influence ...
Friedman Allon N AN Department of Medicine, Division of Nephrology, Indiana University School of Medicine, Indianapolis, IN 46202, USA. - - 2013
Little is known about risk factors for sudden cardiac death in hemodialysis patients during the high-risk first year of dialysis. We therefore undertook to identify such risk factors in a nationally representative cohort and were able to include baseline levels of blood fatty acids, some of which influence arrhythmogenicity and ...
Otaki Yoichiro - - 2012
Renal dysfunction is reported to be associated with poor outcomes in patients with chronic heart failure (CHF). A recent study showed that acidic urine is related to chronic kidney disease, which is a risk factor for the development of CHF. However, it remains to be determined whether acidic urine is ...
Yin Xiaoke X King's BHF Centre, King's College London, - - 2013
Perhexiline is a potent anti-anginal drug used for treatment of refractory angina and other forms of heart disease. It provides an oxygen sparing effect in the myocardium by creating a switch from fatty acid to glucose metabolism through partial inhibition of carnitine palmitoyltransferase 1 and 2. However, the precise molecular ...
Zeng Huahui - - 2013
This study reports the synthesis and evaluation studies of 6'-cyclopentadienyl tricarbonyl technetium-99m 6'-oxo-11-(hexanamide)undecanoic acid (1). 1 was prepared with 26.5 ± 4.3% of radiochemical yield and more than 98% of radiochemical purity. Tissue distribution in mice showed that high radioactivity accumulated in the heart with moderate clearance. However, unfortunately, similar to those ...
Yazicioğlu M V - - 2012
Recent findings suggest that there is a close relationship between chronic heart failure and uric acid. The aim of the study was to assess whether increased uric acid levels in patients with dilated cardiomyopathy might correlate with the degree of functional mitral regurgitation (MR). Sixty two consecutive patients diagnosed with ...
Galvao Tatiana F TF Division of Cardiology, Department of Medicine, University of Maryland, 20 Penn St., Baltimore, MD 21201, - - 2013
Mitochondrial dysfunction in heart failure includes greater susceptibility to mitochondrial permeability transition (MPT), which may worsen cardiac function and decrease survival. Treatment with a mixture of the n3 polyunsaturated fatty acids (n3 PUFAs) docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) is beneficial in heart failure patients and increases resistance to ...
Djoussé Luc - - 2012
Although plasma palmitoleic acid has been positively associated with blood pressure, inflammation, and insulin resistance, its association with heart failure has not been investigated. We assessed whether plasma phospholipid cis-palmitoleic acid was associated with heart failure risk. This ancillary study of the Physicians' Health Study used a risk set sampling ...
Mahaffey Ryan - - 2012
OBJECTIVE: Intravenous antifibrinolytics are the gold standard for blood conservation during cardiac surgery. Recent evidence suggests that topical tranexamic acid administration also is effective, although the efficacy of combined topical and intravenous administration has never been reported. Combined administration may offer superior hemostasis while decreasing side effects. The current study ...
Kromhout Daan - - 2012
PURPOSE OF REVIEW: The fish fatty acids eicosapentenoic acid (EPA) and docosahexenoic acid (DHA) may be protective against fatal coronary heart disease (CHD) and sudden cardiac death. This review summarizes the recent findings of prospective cohort studies and randomized controlled trials. RECENT FINDINGS: A recently published meta-analysis of 17 prospective ...
Ayyash M M - - 2012
The effect of partial substitution of NaCl with KCl on Akawi cheese with probiotic bacteria was investigated during 30 d of storage at 4°C. Chemical composition, the survival of probiotic and lactic acid bacteria, proteolytic activity, and texture profile analysis were analyzed and sensory analysis was carried out to determine ...
Ramadeen Andrew - - 2012
BACKGROUND: -The potential health benefits of omega-3 polyunsaturated fatty acids (PUFAs) are usually studied using a combination of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA).This combination reduces vulnerability to experimentally induced atrial fibrillation (AF). It is unknown whether EPA and DHA have differential effects when taken alone. Using a model ...
Sun Gwo-Shing - - 2012
The National Aeronautics and Space Administration's standard spaceflight diet for rodents is the nutrient-upgraded rodent food bar (NuRFB). The shelf life of the NuRFB needs to be determined in order to avoid malnutrition of rodents and confounding of research results resulting from nutritional deficiency. The authors compared the oxidative and ...
Radočaj Olga - - 2012
A stable, oil-based spread rich in the omega-3 (ω-3) and omega-6 (ω-6) fatty acids was developed using a hull-less pumpkin seed (Cucurbita pepo L.) oil press-cake, a by-product of the pumpkin oil pressing process, along with cold-pressed hemp oil. Response surface methodology (RSM) was applied to investigate the effects of ...
Li Longjun - - 2012
The polyprotic acid H(3)PO(4) in a Li(2)SO(4) supporting electrolyte has been effectively utilized as a catholyte donating three protons in dual-electrolyte Li-air cells. The cell offers a high capacity of 740 mA h g(-1) at an average cell voltage of 3.3 V with good rechargeability and stability.
Zhang Ying - - 2012
Rosemary, whose major caffeoyl-derived and diterpenoid ingredients are rosmarinic acid, carnosol and carnosic acid, is an important source of natural antioxidants and is being recognized increasingly as a useful preservative, protectant, and even as a potential medicinal agent. Understanding the stability of these components and their mode of interaction in ...
Rigane Ghayth - - 2012
BACKGROUND: The aim of this work was to study the chemical characteristics of two Tunisian cultivars, namely Dhokar and Gemri-Dhokar, to analyse the fatty acids, sterols, triacylglycerols, triterpenic alcohols, and to determine the phenolic composition and oxidative stability. RESULTS: Among the rare varieties, Gemri-Dhokar olive oil had the highest value ...
Yahia L Ben - - 2012
At the industrial scale, the major source of olive oil deterioration is the poor handling of the raw material during the time separating harvesting from processing. The objective of this work was to verify the effect of modified atmospheres and cold storage in relation to quality parameters of the extracted ...
Massa Ae - - 2012
The objective of this study was to develop a quality index method for Engraulis anchoita stored in ice and to determine its shelf-life based on this quality index method and chemical indices such as total volatile bases and thiobarbituric acid-reactive substances. Besides, the chemical composition with emphasis on the polyunsaturated ...
Okuma Emile Kasende - - 2012
A DFT study is performed to determine the stability of the complexes formed between either the N or O site of 3-methyl-4-pyrimidone and 1-methyl-2-pyrimidone molecules and different ligands. The studied ligands are boron and alkali Lewis acids, namely B(CH3)3, HB(CH3)2, H2B(CH3), BH3, H2BF¬¬¬, HBF2, BF3, Li+, Na+ and K+. The ...
Gutiérrez-Moreno Nini J - - 2012
Interactions of 2-, 3- and 4-formyl phenylboronic acids (FPBAs) with sugars, amino sugars, aminoglycosides and various poly- and monoamines have been studied by UV-vis, (1)H and (11)B NMR titrations in water at variable pH. Behavior of 2-FPBA was anomalous in several aspects. Transformation of the acid into its conjugate base ...
Hasabelnaby Sherifa - - 2012
Various water-soluble L-valine-, L-glutamate-, and glycine ester prodrugs of two 3-Carboranyl Thymidine Analogs (3-CTAs), designated N5 and N5-2OH, were synthesized for Boron Neutron Capture Therapy (BNCT) of brain tumors since the water solubilities of the parental compounds proved to be insufficient in preclinical studies. The amino acid ester prodrugs were ...
Demirci Sema - - 2012
Poly(2-(2,5-di(thiophen-2-yl)-1H-pyrrol-1-yl) (SNS) acetic acid) was electrochemically deposited on graphite electrodes and functionalized with lysine (Lys) amino acid and poly(amidoamine) derivatives (PAMAM G2 and PAMAM G4) to investigate their matrix properties for biosensor applications. Glucose oxidase (GOx) was immobilized onto the modified surface as the model enzyme. X-Ray photoelectron spectroscopy (XPS) and atomic ...
Steinigeweg Dennis - - 2012
A simple two-step seed-mediated synthesis of monodisperse quasi-spherical silver nanoparticles by citrate and ascorbic acid reduction is presented. Control over monodispersity is achieved by a variety of compounds with hydroxyl groups such as glycerol, ethylene glycol, agarose, or sucrose. The latter can also be used as a matrix for storage.
Christensen Niels Peter Aae - - 2012
The aim of the present study was to combine vibrational spectroscopy and chemometrics for investigating excipient-induced disproportionation of the calcium salt of atorvastatin into the corresponding free acid form in environments relevant to manufacturing and storage of solid dosage formulations. Of the excipients investigated, citric acid and polyacrylic acid were ...
Liu Bin - - 2012
Defective catabolite export from lysosomes results in lysosomal storage diseases in humans. Mutations in the cystine transporter gene CTNS cause cystinosis, but other lysosomal amino acid transporters are poorly characterized at the molecular level. Here, we identified the Caenorhabditis elegans lysosomal lysine/arginine transporter LAAT-1. Loss of laat-1 caused accumulation of ...
Pottala James V - - 2012
Red blood cell (RBC) fatty acid (FA) patterns have been shown to predict risk for cardiovascular and other chronic diseases. As part of a project analyzing RBC samples from the Women's Health Initiative Memory Study (WHIMS) we observed implausibly low levels of highly unsaturated fatty acids (HUFA) suggestive of degradation. ...
Saavedra Carlos J - - 2012
Short α,β,α-tripeptides comprising a central chiral trisubstituted β(2,2,3)*-amino acid residue form unusual γ-turns and δ-turns in CDCl(3) and DMSO-d(6) solutions but do not form β-turns. Thermal coefficients of backbone amide protons, 2D-NMR spectra, and molecular modeling revealed that these motifs were strongly dependent on the configuration (chiral effect) of the ...
Lata Suman - - 2012
A nickel hexacyanoferrate polypyrrole film was synthesized through an electrochemical two-step methodology leading to a very stable and homogenous robust hybrid film. A highly sensitive, specific and rapid amperometric D: -amino acid biosensor was constructed by immobilizing D: -amino acid oxidase on this film deposited over the surface of a ...
Lee Seungmin - - 2012
Metabolic syndrome is one of the major factors to increase the incidence of heart failure. In our study, we compared plasma fatty acid compositions among heart failure patients with and without Metabolic syndrome. Fatty acid (FA) composition of plasma phospholipids was analyzed and the activities of desaturase were estimated as ...
Santos L M - - 2012
A racemic crystalline form of terebic acid, C(7)H(10)O(4), which is an important industrial chemical compound, is reported for the first time. The crystal structure is stabilized by O-H...O and C-H...O hydrogen bonds which form racemic double layers parallel to (001).
Kan Shidong - - 2012
Resting cells of Fusarium oxysporum f. sp. Cucumerinum (F. oxsporum) were used for the biotransformation of salvianolic acid B (Sal B). Three transformed products, isolithospermic acid, prolithospermic acid and danshensu, were identified on the basis of chemical and spectroscopic data. The stability of the two ester bonds of Sal B ...
Paredes Eduardo - - 2012
The copper(I) catalyzed azide-alkyne cycloaddition 'click' reaction yields a specific product under mild conditions and in some of the most chemically complex environments. This reaction has been used extensively to tag DNA, proteins, glycans and only recently RNA. Click reactions in aqueous buffer typically include a ligand for Cu(I), however ...
McKenzie Marian J - - 2012
Cold-induced sweetening (CIS) is a serious postharvest problem for potato tubers, which need to be stored cold to prevent sprouting and pathogenesis in order to maintain supply throughout the year. During storage at cold temperatures (below 10 (o) C), many cultivars accumulate free reducing sugars derived from a breakdown of ...
Park Young-Seo - - 2012
The effects of kimchi and freeze-dried kimchi-powder added to raw meat mixtures on the microbiological quality of fermented sausage were studied. The results clearly demonstrated that the lactic acid bacteria (LAB) integrated via the addition of kimchi as well as kimchi-powder were well adapted to the new habitat of fermenting ...
Hu Xun - - 2012
Acid treatments of xylose have been performed in a methanol/water mixture to investigate the reaction pathways of xylose during bio-oil esterification. Xylose was mainly converted into methyl xylosides with negligible humins formed below 130 °C. However, humins formation became significant with the dehydration of xylose to furfural and 2-(dimethoxymethyl)furan (DOF) at ...
Alborzi Solmaz - - 2012
In this study, we investigated the effect of alginate-pectin-poly(ethylene oxide) (PEO) electrospun fibres on the stability of folic acid. Fibre-forming solutions containing folic acid were prepared by blending low- or medium-viscosity alginate with pectin. PEO was added to make the electrospinning process possible. Folic acid encapsulated in electrospun fibres achieved ...
Lee M R F - - 2012
When fractionation of meat lipids is not required, procedures such as saponification can be used to extract total fatty acids, reducing reliance on toxic organic compounds. However, saponification of muscle fatty acids is laborious, and requires extended heating times, and a second methylation step to convert the extracted fatty acids ...
Nakano Shu-Ichi - - 2012
Characterization of metal ion binding to RNA and DNA base pairs is important for understanding their energy contribution to the folding and conformational changes of nucleic acid structures. In this study, we examine the equilibrium shift from the hairpin toward the dimer formation, induced by nonspecifically bound metal ions. The ...
Kannoujia Dileep Kumar - - 2012
Herein, a simple and rapid method is described for detection of l-ascorbic acid by ascorbate oxidase immobilized onto polycarbonate strip pre-activated by 1-fluoro-2-nitro-4-azidobenzene in photochemical reaction. Covalent attachment of ascorbate oxidase was confirmed by XPS studies. The immobilized-ascorbate oxidase shows higher pH, thermal and storage stability in comparison to free ...
Conti Fosca - - 2012
Poly(2,5-benzimidazole) (AB-PBI) membranes are investigated by studying the FT-Raman signals due to the benzimidazole ring vibration together with the C-C and C-H out-of- and in-plane ring deformations. By immersion in aqueous ortho-phosphoric acid for different time periods, membranes with various doping degrees, i.e. different molar fractions of acid, are prepared. ...
Liu Yihan - - 2012
AIMS: The purpose of this research was to obtain the mutant of Bacillus licheniformis alpha amylase (BLA) with improved acid stability and elucidate the difference in catalytic mechanism under acidic conditions between wild type and mutant BLAs. METHODS AND RESULTS: The stability of BLA under acid condition was enhanced through ...
Sahle Fitsum F - - 2012
Ceramide AP (CER [AP]) is an integral component of the stratum corneum (SC) lipid matrix and is capable of forming tough and super stable lamellae. It may help to restore the barrier function in aged and affected skin. However, its effectiveness from conventional dosage forms is limited due to its ...
Shokri Alireza - - 2012
The pKa of an acyclic aliphatic heptaol ((HOCH2CH2CH(OH)CH2)3COH) was measured in DMSO and its gas-phase acidity is reported as well. This tertiary alcohol was found to be 1021 times more acidic than tert-butanol in DMSO and an order of magnitude more acidic than acetic acid (i.e., pKa = 11.4 vs ...
- - 2012
At the request of the Managing Editor the following paper has been retracted: F. Pop. (2011). 'Chemical stabilization of oils rich in long-chain polyunsaturated fatty acids during storage', Food Science and Technology International 17: 111-117, DOI: 10.1177/1082013210368738.
Grassino A Nincevic - - 2012
In this research compositional changes of tinplate-canned tomato purées, with or without the addition of essential onion oil were investigated. The study was focused on the analyses of carbohydrates and carboxylic acids in two groups of canned samples (with or without nitrates) to determine whether their chemical composition was affected ...
Parks A R Hoyle - - 2012
Lactic acid bacteria (LAB) can reduce Escherichia coli O157:H7 and Salmonella spp. in ground beef during storage. Furthermore, the addition of rosemary oleoresin (RO), a natural antioxidant, to ground beef has been shown to increase shelf life and is commonly used in modified-atmosphere packaged (MAP) ground beef. This study evaluated ...
Rodrigues Nuno - - 2012
Lipids oxidation is one of the main factors leading to quality losses in foods. Its prevention or delay could be obtained by the addition of antioxidants. In this sense the present work intend to monitor the protective effects of Lavandula latifolia essential oil during soybean oil microwave heating. To achieve ...
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