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Hymas Richard V RV Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, - - 2014
The purpose of the present study was to gain quantitative mechanistic insight into the role cyclodextrin carriers may play in the intestinal absorption of highly lipophilic molecules. The physical model approach was employed to investigate capric acid absorption in the rat ileum using the in situ single-pass method with 2-hydroxypropyl-β-cyclodextrin ...
da Encarnação Joana Amarante JA School of Food Science and Nutrition, University of Leeds, United - - 2014
Coffee is rich in quinic acid esters of phenolic acids (chlorogenic acids) but also contains some free phenolic acids. A proportion of phenolic acids appear in the blood rapidly after coffee consumption due to absorption in the small intestine. We investigated in vitro whether this appearance could potentially be derived ...
Yamazaki Tohru T School of Pharmaceutical Sciences, Josai University, 1-1 Keyakidai, Sakado, Saitama, 350-0295, - - 2014
Fibrates have been reported to elevate the hepatic proportion of oleic acid (18:1n-9) through inducing stearoyl-CoA desaturase (SCD). Despite abundant studies on the regulation of SCD in the liver, little is known about this issue in the small intestine. The present study aimed to investigate the effect of clofibric acid ...
Fanjul Carmen C C Fanjul, Nutrition, Food Science and Physiology, University of Navarra, Pamplona, - - 2014
Leptin is secreted by the gastric mucosa and is able to reach the intestinal lumen and bind to its receptors located in the apical membrane of the enterocytes. We have previously demonstrated that apical leptin inhibits amino acids uptake in rat intestine in vitro and in Caco-2 cells. The aim ...
Ahirwar Suneel Kumar SK Department of - - 2014
Salmonella Typhi faces several environmental stresses while going through the stomach (acidic pH) to small intestine (basic pH) and intracellularly in macrophages (acidic pH) in humans. The acidic pH followed by alkaline pH in small intestine might be responsible for expression of certain stress induced genes resulting into not only ...
Fuchs Alexander A Institute of Pharmaceutical Technology, Goethe University, Frankfurt am Main, - - 2014
Various methods of sampling and analyzing intestinal fluids have been applied over the years. In this report, data that have been published to date about the composition of fasted-state human intestinal fluid (HIF) and its physicochemical properties are summarized and the influence of the methods used to generate the data ...
Li X-G XG College of Animal Science,South China Agricultural University/Guangdong Provincial Key Laboratory of Agro-Animal Genomics and Molecular Breeding/Key Laboratory of Chicken Genetics,Breeding and Reproduction,Ministry of Agriculture,Guangzhou,510642,P. R. - - 2014
Glutamate, which is one of the most important contributors to oxidative metabolism in the intestinal mucosa, is mainly transported by the excitatory amino acids transporters (EAATs) that are expressed in enterocytes. The objective of this study was to evaluate the effects of in ovo administration of l-trans pyrrolidine-2,4-dicarboxylic acid (l-trans-PDC), ...
Peterson Maria L ML Department of Biology, University of North Florida, Jacksonville, FL, 32224, - - 2014
Gas chromatography was used to measure transepithelial transport of glycylsarcosine (Gly-Sar) by perfused lobster (Homarus americanus) intestine. Unidirectional and net fluxes of dipeptide across the tissue and luminal factors affecting their magnitude and direction were characterized by perfusing the lumen with the dipeptide and measuring its appearance in saline on ...
Chen Peng P Department of Medicine, University of California San Diego, La Jolla, - - 2014
Alcoholic liver disease is a leading cause of mortality. Chronic alcohol consumption is accompanied by intestinal dysbiosis, and development of alcoholic liver disease requires gut-derived bacterial products. However, little is known about how alterations to the microbiome contribute to pathogenesis of alcoholic liver disease. We used the Tsukamoto-French mouse model ...
Dawson Paul A PA Emory University School of Medicine, United States - - 2014
In addition to their classical roles as detergents to aid in the process of digestion, bile acids have been identified as important signaling molecules that function through various nuclear and G-protein coupled receptors to regulate a myriad of cellular and molecular functions across both metabolic and non-metabolic pathways. Signaling via ...
Lan Annaïg A *UMR 914 INRA/AgroParisTech, Nutrition Physiology and Ingestive Behavior, Paris, France; †Department of Gastroenterology, Avicenne Hospital, Assistance Publique-Hôpitaux de Paris, Bobigny, France; ‡Department of Digestive Surgery, Jean Verdier Hospital, Assistance Publique-Hôpitaux de Paris, Bobigny, France; §Laboratory of Applied Nutrition and Metabolism, School of Physical Education and Sports, University of Sao Paulo, Sao Paulo, Brazil; ‖Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha, China; ¶INSERM U773, Biomedical Research Center Bichat Beaujon/Paris7 University, Paris, - - 2014
: Advanced mucosal healing (MH) after intestinal mucosal inflammation coincides with sustained clinical remission and reduced rates of hospitalization and surgical resection, explaining why MH is increasingly considered as a full therapeutic goal and as an endpoint for clinical trials. Intestinal MH is a complex phenomenon viewed as a succession ...
Li Rongsong R Division of Cardiology, Department of Medicine, School of Medicine, University of California; and Biomedical Engineering, University of Southern California, Los Angeles, California, - - 2014
Background and Objective: Exposure to ambient ultrafine particulate matter (UFP) is a well-recognized risk factor for cardiovascular and respiratory diseases. However, little is known about the effects of air pollution on gastrointestinal disorders. We sought to assess whether exposure to ambient ultrafine particles (UFP: diameter < 180 nm) increased free ...
Geirnaert Annelies A Laboratory of Microbial Ecology and Technology (LabMET), Ghent University, Coupure Links 653, 9000 Ghent, - - 2014
Butyrate has several beneficial properties that are essential to maintain gastrointestinal health. Therefore butyrate-producing bacteria are seen as the next generation of probiotics. The butyrate-producing bacterium Butyricicoccus pullicaecorum (a clostridial cluster IV strain) is such a promising probiotic candidate for people suffering from inflammatory bowel disease. To exert its beneficial ...
Heubi James E JE Division of Gastroenterology, Hepatology and Nutrition, University of Cincinnati, Cincinnati, OH; Clinical and Translational Research Center, University of Cincinnati, Cincinnati, - - 2014
Bile acid amidation defects were predicted to present with fat/fat soluble vitamin malabsorption with minimal cholestasis. We identified and treated 5 patients (1 male/4 females) from 4 families with defective bile acid amidation due to a genetically confirmed deficiency in bile acid CoA:amino acid N-acyl transferase (BAAT) with the conjugated ...
Typpo Katri V KV 1Department of Pediatrics and the Steele Children's Research Center, University of Arizona, Tucson, AZ. 2Department of Anesthesia, University of Arizona, Tucson, AZ. 3Department of Immunobiology, University of Arizona, Tucson, - - 2014
Children with congenital heart disease have loss of intestinal epithelial barrier function, which increases their risk for postoperative sepsis and organ dysfunction. We do not understand how postoperative cardiopulmonary support or the inflammatory response to cardiopulmonary bypass might alter intestinal epithelial barrier function. We examined variation in a panel of ...
Kosińska-Cagnazzo Agnieszka A Institute of Life Technologies, University of Applied Sciences and Arts Western Switzerland, Route du Rawyl 47, CH-1950 Sion, Switzerland; Division of Food Sciences, Institute of Animal Reproduction and Food Research of The Polish Academy of Sciences, Tuwima 10, 10-748 Olsztyn, Poland. Electronic address: - - 2015
Strawberry fruits are highly valued for their taste and nutritional value. However, results describing the bioaccessibility and intestinal absorption of phenolic compounds from strawberries are still scarce. In our study, a combined in vitro digestion/Caco-2 absorption model was used to mimic physiological conditions in the gastrointestinal track and identify compounds ...
Jiang Yan Y Internal Medicine, University of - - 2014
Prostaglandin E2 (PGE2) has been linked to a higher risk of colorectal cancer. PGE2 in colon tissue can be reduced by increasing dietary eicosapentaenoic acid (EPA). The dose-dependent relationships between dietary EPA, serum EPA:arachidonate (AA) ratio, urinary PGE2 metabolites and colonic eicosanoids were evaluated to develop biomarkers for prediction of ...
Psichas A A Nutrition and Dietetic Research Group, Section of Investigative Medicine, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Hammersmith Campus, Imperial College London, - - 2014
Background and Objectives:The gut hormones PYY and GLP-1 acutely suppress appetite. The short chain fatty acid (SCFA) receptor, free fatty acid receptor 2 (FFA2) is present on colonic enteroendocrine L cells, and a role has been suggested for SCFAs in appetite regulation. Here we characterise the in vitro and in ...
Camargo Simone M R SM Institute of Physiology and Zurich Center for Integrative Human Physiology, University of Zurich, Zu; - - 2014
Levodopa (L-DOPA) is the naturally occurring precursor amino acid for dopamine and the main therapeutic agent for neurologic disorders due to dopamine depletion, such as Parkinson's disease. Levodopa absorption in small intestine has been suggested to be mediated by the large neutral amino acids transport machinery, but the identity of ...
Okamura Ayako A Kyushu University, - - 2014
Digested proteins are mainly absorbed as small peptides composed of two or three amino acids. The intestinal absorption of small peptides is mediated via only one transport system: the proton-coupled peptide transporter-1 (PepT1) encoded from the soluble carrier protein Slc15a1. In mammals, intestinal expression of PepT1/Slc15a1 oscillates during the daily ...
Chen He-Ping HP a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201 , - - 2014
Three new bisabolane sesquiterpenoids, inonotic acid A (1), 3-O-formyl inonotic acid A (2), inonotic acid B (3), and one new drimane sesquiterpenoid 3α,6β-dihydroxycinnamolide (4), were isolated from the fruiting bodies of mushroom Inonotus rickii. Their structures were elucidated by means of extensive spectroscopic methods. Compound 4 had moderate inhibitory activity ...
Wang Bin B State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing, 100193, People's Republic of - - 2014
The intestinal barrier integrity is essential for the absorption of nutrients and health in humans and animals. Dysfunction of the mucosal barrier is associated with increased gut permeability and development of multiple gastrointestinal diseases. Recent studies highlighted a critical role for glutamine, which had been traditionally considered as a nutritionally ...
Centuori Sara M SM Department of Cellular and Molecular Medicine, The University of Arizona Cancer Center, 1515 N. Campbell Ave., PO Box 245024, Tucson, AZ, 85724-5024, USA, - - 2014
A high-fat diet coincides with increased levels of bile acids. This increase in bile acids, particularly deoxycholic acid (DCA), has been strongly associated with the development of colon cancer. Conversely, ursodeoxycholic acid (UDCA) may have chemopreventive properties. Although structurally similar, DCA and UDCA present different biological and pathological effects in ...
Cha Yun Suk YS School of Biological Sciences, College of Biomedical Sciences and Engineering, Inje University, - - 2014
Lactic acid bacteria (LAB) are probiotics, which provide numerous beneficial effects on the host body, especially, on the intestine. Combining several strains of LAB, we prepared a formulation containing four different LAB and studied its anti-inflammatory activity both in vitro and in vivo. The formulation significantly reduced NO production from ...
Huang Chunxi C State Key Laboratory for Animal Nutrition, China Agricultural University, Beijing 100193, - - 2014
Three experiments were conducted to determine the effect of taurine on the intestinal development, bile acid concentrations, and hormonal status of chickens. In experiment 1, a total of 250 one-day-old broilers were randomly allocated to 5 treatments and supplemented with 0, 0.25, 0.50, 1.00, and 2.00 g/kg of taurine, respectively. ...
Uraipan Supansa S Department of Industrial Biotechnology, Faculty of Agro-Industry, Prince of Songkla University, Hat Yai, Songkhla 90112 - - 2014
Antagonistic mechanisms of Lactobacillus plantarum CIF17AN2 (an infant isolate), saba starch, and their synbiotic combination against Salmonella Typhimurium SA2093 were evaluated. The anti-Salmonella activity was investigated under the competitive niche of fecal microbiota using the simulated proximal colon model. The alterations of the dominant fecal microbiota and beneficial bacteria were ...
Milbradt E L EL Department of Veterinary Clinical Sciences, School of Veterinary Medicine and Animal Science, São Paulo State University (UNESP), Botucatu, São Paulo, - - 2014
To evaluate the use of organic acids (OAs) and competitive exclusion (CE) product administered continuously in the feed and transiently in drinking water on the control of Salmonella enterica subspecie enterica serotype Enteritidis (SE) prior to slaughter. The influence of treatments were evaluated on pH, population of the lactic acid ...
Algieri Francesca - - 2014
Intestinal microbiota modulation is becoming an interesting approach to manage inflammatory bowel disease, and can be achieved by the administration of prebiotics. Previous studies showed the intestinal anti-inflammatory effects of the prebiotic lactulose. The aim of the present study was to test the preventative effects of oligosaccharides derived from lactulose ...
Barroso E E Departamento de Biotecnología y Microbiología de Alimentos, Instituto de Investigación en Ciencias de la Alimentación CIAL (CSIC-UAM), Nicolás Cabrera 9, 28049, Madrid, - - 2014
The colonic microbiota plays an important role in the bioavailibility of dietary polyphenols. This work has evaluated the impact on the gut microbiota of long-term feeding with both a red wine polyphenolic extract and the flavan-3-ol metabolizer strain Lactobacillus plantarum IFPL935. The study was conducted in the dynamic Simulator of ...
Pimpão Rui C RC Instituto de Tecnologia Química e Biológica, Universidade Nova de Lisboa, Av. da República, EAN, Oeiras, - - 2014
The colonic metabolism of dietary flavonoids, phenolic acids and their phenolic metabolites is complex and many metabolites and conjugates have not yet been unambiguously identified in humans. Urine samples from nine healthy human volunteers obtained after the ingestion of a puree of five (poly)phenol-rich berry fruits were analysed using LC-Orbitrap ...
Röytiö H H Kantvik Active Nutrition, DuPont Nutrition and Health, Sokeritehtaantie 20, 02460 Kantvik, Finland Functional Foods Forum and Institute of Biomedicine, 20014 University of Turku, - - 2014
Polydextrose is a randomly bonded glucose polymer with a highly branched and complex structure. It resists digestion in the upper gastrointestinal tract and is partially fermented in the large intestine by the colonic microbes. Due to its complex structure, a plethora of microbes is required for the catabolism of polydextrose ...
Dhaneshwar Suneela S SS Suneela S Dhaneshwar, Department of Pharmaceutical Chemistry, Poona College of Pharmacy, Bharati Vidyapeeth Deemed University, Pune-411 038, Maharashtra, - - 2014
Despite the advent of biological products, such as anti-tumor necrosis factor-α monoclonal antibodies (infliximab and adalimumab), for treatment of moderate to severe cases of inflammatory bowel disease (IBD), most patients depend upon aminosalicylates as the conventional treatment option. In recent years, the increased knowledge of complex pathophysiological processes underlying IBD ...
Yang Guo-Xun GX a Department of Natural Products Chemistry , School of Pharmacy, Fudan University , No. 826 Zhangheng Road, Shanghai 201203 , P.R. - - 2014
In search of anti-inflammatory lead compounds from traditional Chinese medicines, a bioassay-guided phytochemical study on Melastoma dodecandrum was carried out. As a result, 18 compounds have been isolated. Their chemical structures were determined on the basis of their physicochemical properties and spectral data. Among the isolates, three pentacyclic triterpenoids, ursolic ...
Mei Li - - 2014
A novel intestinal-targeted carrier for pH-responsive protection of Lactic acid bacteria in stomach and rapid release of Lactic acid bacteria in small intestine is successfully developed. The proposed carrier is composed of a Ca-alginate/protamine (CAP) composite shell and a Lactobacillus-casei-encapsulated Ca-alginate (CA) core. The carriers are prepared simply by a ...
Piazzi Giulia G Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy; Center for Applied Biomedical Research (CRBA), S. Orsola-Malpighi Hospital, University of Bologna, Bologna, - - 2014
Inflammatory bowel diseases are associated with increased risk of developing colitis-associated colorectal cancer (CAC). Epidemiological data show that the consumption of ω-3 polyunsaturated fatty acids (ω-3 PUFAs) decreases the risk of sporadic colorectal cancer (CRC). Importantly, recent data have shown that eicosapentaenoic acid-free fatty acid (EPA-FFA) reduces polyp formation and ...
Cazarin Cinthia Bb CB Department of Food and Nutrition, School of Food Engineering, University of Campinas, 13083-862, Campinas/SP, - - 2014
Inflammatory bowel disease is a chronic relapsing disease that affects millions of people worldwide; its pathogenesis is influenced by genetic, environmental, microbiological, and immunological factors. The aim of this study was to evaluate the effects of short- and long-term Passiflora edulis peel intake on the antioxidant status, microbiota, and short-chain ...
Cho H T HT Department of Food Science, University of Massachusetts, Amherst, MA 01003, - - 2014
The influence of droplet size (d32=0.21, 0.70 or 2.2μm) and oil digestibility (corn oil versus mineral oil) on the bioavailability of a model long chain fatty acid (heptadecanoic acid) and lipophilic nutraceutical (Coenzyme Q10) was investigated using a rat feeding study. Initially, we showed that small droplets were digested more ...
Dodda Dilip D University College of Pharmaceutical Sciences, Kakatiya University, Warangal, India; Department of Pharmacology, Vaagdevi College of Pharmacy, Warangal, India. Electronic address: - - 2014
Inflammatory bowel disease (IBD) is characterized by most common symptoms such as rectal bleeding. Lack of specific, curative treatments tempted us to evaluate the therapeutic efficacy of quercetin against acetic acid induced IBD like symptoms. Animals were randomly divided into five groups (n=6): naive, control, sulphasalazine and quercetin, and were ...
González J J Departamento de Producción Animal, Escuela Técnica Superior de Ingenieros Agrónomos, Universidad Politécnica de Madrid, Ciudad Universitaria, 28040, Madrid, - - 2014
Microbial corrected in situ estimates of ruminal undegraded fraction (RU) and intestinal effective digestibility (IED) of amino acids (AA) except tryptophan of rye, wheat and corn grains, wheat bran, wheat- or barley-distilled dried-grains and corn gluten feed were measured on three rumen and duodenum cannulated wethers using (15) N labeling-techniques ...
Clark David A DA Albany Medical College, Albany, NY, United States. Electronic address: - - 2014
Neonatal necrotizing enterocolitis which develops after feeding preterm infants is characterized by severe intestinal inflammation and profound systemic metabolic acidosis. The fermentation of undigested dietary carbohydrate by colonic flora yields gases (CO2 and H2) and short chain organic acids. These organic acids can disrupt the intestinal mucosa and initiate inflammation ...
Plett Jonathan M JM INRA, UMR 1136 INRA-University Henri Poincaré, Lab of Excellence ARBRE, Interactions Arbres/Microorganismes, INRA-Nancy, 54280, Champenoux, France; Hawkesbury Institute for the Environment, University of Western Sydney, Richmond, NSW, 2753, - - 2014
The plant hormones ethylene, jasmonic acid and salicylic acid have interconnecting roles during the response of plant tissues to mutualistic and pathogenic symbionts. We used morphological studies of transgenic- or hormone-treated Populus roots as well as whole-genome oligoarrays to examine how these hormones affect root colonization by the mutualistic ectomycorrhizal ...
Druart Céline C Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Université catholique de Louvain, Brussels, - - 2014
In vitro studies have suggested that isolated gut bacteria are able to metabolize PUFA into CLA (conjugated linoleic acids) and CLnA (conjugated linolenic acids). However, the bioavailability of fatty acid metabolites produced in vivo by the gut microbes remains to be studied. Therefore, we measured intestinal concentration and plasma accumulation ...
Ren Wenkai W Scientific Observing and Experimental Station of Animal Nutrition and Feed Science in South-Central, Ministry of Agriculture, Hunan Provincial Engineering Research Center of Healthy Livestock Key Laboratory of Agro-ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha, Hunan, - - 2014
This study was conducted to investigate serum amino acids profile in dextran sulfate sodium (DSS)-induced colitis, and impacts of graded dose of arginine or glutamine supplementation on the colitis. Using DSS-induced colitis model, which is similar to human ulcerative colitis, we determined serum profile of amino acids at day 3, ...
Reimer Raylene A RA Faculty of Kinesiology and Department of Biochemistry & Molecular Biology, University of Calgary, Calgary, AB T2N 1N4, Canada. - - 2014
Many of the health benefits associated with dietary fiber are attributed to their fermentation by microbiota and production of short chain fatty acids (SCFA). The aim of this study was to investigate the fermentability of the functional fiber PolyGlyopleX® (PGX®) in vitro. A validated dynamic, computer-controlled in vitro system simulating ...
Bertin Yolande Y Institut National de la Recherche Agronomique, UR454 Microbiologie, Saint-Genès-Champanelle, - - 2014
Enterohaemorrhagic Escherichia coli (EHEC) are responsible for outbreaks of food- and water-borne illness. The bovine gastrointestinal tract (GIT) is thought to be the principle reservoir of EHEC. Knowledge of the nutrients essential for EHEC growth and survival in the bovine intestine may help in developing strategies to limit their shedding ...
Smędra-Kaźmirska A A dr n. med. Anna Smędra-Kaźmirska Katedra i Zakład Medycyny Sądowej Uniwersytet Medyczny ul. Sędziowska 18 A 91-304 Łódź tel. +48 42 654 45 36 faks +48 42 654 42 93 e-mail: - - 2014
The paper describes a fatal case of accidental ingestion of a mixture of hydrochloric acid and hydrofluoric acid. The man was admitted to hospital, where appropriate treatment, adequate to his condition, was instituted. Numerous ventricular fibrillation episodes, for which the patient was defibrillated repeatedly, were observed during the period of ...
Zhou Xueyan X 1] State Key Laboratory of Natural Medicines, Key Lab of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Tongjiaxiang 24, Nanjing 21009, China [2] School of Pharmacy, Xuzhou Medical College, Xuzhou 221004, Jiangsu, China - - 2014
Bile acids play a pivotal role in the pathological development of inflammatory bowel disease (IBD). However, the mechanism of bile acid dysregulation in IBD remains unanswered. Here we show that intestinal peroxisome proliferator-activated receptor α (PPARα)-UDP-glucuronosyltransferases (UGTs) signalling is an important determinant of bile acid homeostasis. Dextran sulphate sodium (DSS)-induced ...
Zhou Wei W College of Pharmacy, Nan'jing University of Chinese Medicine, Nan'jing, People's Republic of China; Jiang'su Engineering Research Center for Efficient Delivery System of TCM, Nan'jing, People's Republic of China; Nan'jing Engineering Research Center for Industrialization of Chinese Medicine Pellets, Nan'jing, People's Republic of - - 2014
The Flos Lonicerae-Fructus Forsythiae herb couple is the basic components of Chinese herbal preparations (Shuang-Huang-Lian tablet, Yin-Qiao-Jie-Du tablet and Fufang Qin-Lan oral liquid), and its pharmacological effects were significantly higher than that in Flos Lonicerae or Fructus Forsythiae, but the reasons remained unknown. In the present study, pattern recognition analysis ...
Tomas-Barberan Francisco F Department of Food Science and Technology, CEBAS-CSIC, Murcia, - - 2013
Chlorogenic acid (3-O-caffeoyl-quinic acid, C-QA), the caffeic ester of quinic acid, is one of the most abundant phenolic acids in Western diet. The majority of C-QA escapes absorption in the small intestine and reaches the colon, where the resident microbiota transforms it into several metabolites. C-QA conversion by the gut ...
De Weirdt R - - 2013
Lactobacillus reuteri is a commensal, beneficial gut microbe that colonises the intestinal mucus layer, where it makes close contact with the human host and may significantly affect human health. Here, we investigated the capacity of linoleic acid (LA), the most common polyunsaturated fatty acid (PUFA) in a Western-style diet, to ...
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