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Sarafidis Pantelis A PA Section of Nephrology and Hypertension, 1st Department of Medicine, Aristotle University of Thessaloniki, AHEPA Hospital, St Kiriakidi 1, 54636, Thessaloniki, Greece. - - 2010
As with all potent therapeutic agents, the use of diuretic compounds has been linked with several adverse effects that may reduce quality of life and patient compliance and, in some cases, may be associated with considerable morbidity and mortality. Among the various types of adverse effects, disturbances of electrolyte and ...
Dutta Sounak - - 2010
The gelation of ionic liquids is attracting significant attention because of its large spectrum of applications across different disciplines. These 'green solvents' have been the solution to a number of common problems due to their eco-friendly features. To expand their applications, the gelation of ionic liquids has been achieved by ...
Freeman Laura A - - 2010
PURPOSE: To measure and compare temperature changes in a recently developed gel phantom for thermochemical ablation as a function of reagent strength and concentration with several acids and bases. MATERIALS AND METHODS: Aliquots (0.5-1 mL) of hydrochloric acid or acetic acid and sodium hydroxide or aqueous ammonia were injected for ...
Pilarski Bogus?aw - - 2010
A new approach to modelling of some binary (hydro-organic, HL/H(2)O+B) acid-base systems with organic co-solvent B fully miscible with water, is suggested and applied for the determination of acidity parameters pK for some weak acids HL. The models are designed to get the pK=pK(x) relationships (x-mole fraction of B in ...
Megger Dominik A - - 2010
A 2'-deoxyribonucleoside containing 1,3-dideaza-6-nitropurine was synthesized and incorporated into oligonucleotides. The acid-base properties of this nucleoside and the corresponding N9-methylated derivative were investigated by pD-dependent (1)H NMR spectroscopy. A possible formation of Hoogsteen-type base pairs with cytosine was studied by ultraviolet (UV) and circular dichroism (CD) spectroscopy in the presence ...
Nagami Glenn T - - 2010
Angiotensin II (Ang II) is a major systemic regulator of blood pressure, blood volume, and acid-base homeostasis. However, the effects of local Ang II signaling in the kidney are less well known. Here we review the impact of Ang II on acid-base transport in specific nephron segments and discuss the ...
Vieira Jorge - - 2010
Within Rosaceae, the RNase based gametophytic self-incompatibility (GSI) system has been studied at the molecular level in Maloideae and Prunus species that have been diverging for, at least, 32 million years. In order to understand RNase based GSI evolution within this family, comparative studies must be performed, using similar methodologies. ...
Knight G C - - 2010
A model system was developed for evaluating the efficacy of disinfectants for inactivating bacteria present in biofilms on surfaces within dairy factory environments. Mixed culture biofilms of six dairy factory isolates (pseudomonads, coliforms and presumptive staphylococci) were generated on factory floor tiles and subjected to up to three fouling and ...
Koeppen Bruce M - - 2009
Since the topic of the role of the kidneys in the regulation of acid-base balance was last reviewed from a teaching perspective (Koeppen BM. Renal regulation of acid-base balance. Adv Physiol Educ 20: 132-141, 1998), our understanding of the specific membrane transporters involved in H(+), HCO(3)(-), and NH(4)(+) transport, and ...
Popov Ilya - - 2009
A general method has been developed for in situ trapping of arylmetal intermediates by halogen, sulfur, ketone, and aldehyde electrophiles affording the functionalization of the most acidic position in arene. Pentafluorobenzene, benzothiazole, and benzoxazole can be functionalized by using K(3)PO(4) base. For less acidic arenes, tBuOLi base is required. Arenes ...
Zushi Yasuyuki - - 2010
Perfluorinated compounds (PFCs) were detected in sediment core samples collected in Tokyo Bay to reveal their time trends. The core sample deposited during 1950s-2004 was divided into two- to three-year intervals and the concentrations of 24 types of PFCs were determined. Perfluorooctane sulfonate (PFOS) decreased gradually from the early 1990s ...
Hemmateenejad Bahram - - 2010
The acidity constants of some newly synthesized Schiff base derivatives were determined by hard-model based multivariate data analysis of the spectrophotometric data in the course of pH-metric titration in 50% (v/v) methanol-water binary solvent. The employed data analysis method was also able to extract the pure spectra and pH-dependent concentration ...
Gutowska Magdalena A - - 2010
Acidification of ocean surface waters by anthropogenic carbon dioxide (CO(2)) emissions is a currently developing scenario that warrants a broadening of research foci in the study of acid-base physiology. Recent studies working with environmentally relevant CO(2) levels, indicate that some echinoderms and molluscs reduce metabolic rates, soft tissue growth and ...
Fujimoto Kazuhisa - - 2009
Duplex-based, fluorescent sensors bearing cyclodextrins as a guest-binding moiety were synthesised based on Click chemistry, and the sensors selectively detected unsaturated fatty acids by pyrene-emission switching from monomer to excimer.
Dragoman D - - 2009
In this Brief Report, we present a method for the real-time detection of the bases of the deoxyribonucleic acid using their signatures in negative differential conductance measurements. The present methods of electronic detection of deoxyribonucleic acid bases are based on a statistical analysis because the electrical currents of the four ...
Kruger Seth - - 2009
Five new compounds were synthesized for use as acid amplifiers in EUV (13.5 nm) photoresists. Four compounds act as acid amplifiers and decompose by autocatalytic kinetics to generate fluorinated sulfonic acids, essential for the simultaneous improvement of resolution, sensitivity, and line edge roughness (LER) in EUV photoresists. The decomposition rates ...
Gils Palapparambil Sunny - - 2009
A novel biopolymer-based superporous hydrogel (SPH) was synthesized through chemical crosslinking by graft copolymerization of 2-hydroxyethyl methacrylate (HEMA) and acrylic acid (AA) on to xanthan gum (XG) via redox initiator system of ammonium persulfate (APS) and N, N, N', N'-tetramethylethylenediamine (TMED), in the presence of N, N'-methylenebisacrylamide (MBA) crosslinking agent, ...
Persat Alexandre - - 2009
We present elements of electrolyte dynamics and electrochemistry relevant to microfluidic electrokinetics experiments. In Part I of this two-paper series, we presented a review and introduction to the fundamentals of acid-base chemistry. Here, we first summarize the coupling between acid-base equilibrium chemistry and electrophoretic mobilities of electrolytes, at both infinite ...
Tan Jin - - 2009
A fluorescent indicator-displacement molecular imprinting sensor array based on phenylboronic acid functionalized mesoporous silica was developed for discriminating saccharides. D-Fructose imprinted material (FruIM), D-xylose imprinted material (XylIM) together with a control blank nonimprinted material (NIM) were synthesized as the elements of the imprinting sensor array. Spectrofluorimetric titrations of the three ...
Suh Min Sung - - 2009
Viable siRNA therapeutic strategies require the concurrent development of effective and safe delivery systems. Here, we described the synthesis of a new cationic lipid, N,N''-dioleylglutamide (DG), and evaluated DG-based liposomes as an siRNA delivery system. DG, an amino acid derivative, was synthesized by peptide bond linkage of oleylamine to each ...
Dos Alexandra - - 2009
The acid-base and base-base interactions of the (15)N-labeled side-chain amino groups of dry solid poly-L-lysine (PLL) and the consequences for the secondary structure have been studied using high-resolution solid state (15)N and (13)C CPMAS NMR spectroscopy. In a previous study we had shown that at acid/base ratios of 1 per ...
Ghosh Kumaresh - - 2009
New triphenylamine-based chemosensors for selective recognition of dicarboxylic acids have been designed and synthesized. They are variants of previously synthesized chemosensors, offering different possibilities for selective recognition of dicarboxylic acids. Theoretical calculations by density functional theory and time dependent density functional theory have been carried out on these as well ...
Gilmour K M - - 2009
Carbonic anhydrase (CA) is the zinc metalloenzyme that catalyses the reversible reactions of CO(2) with water. CA plays a crucial role in systemic acid-base regulation in fish by providing acid-base equivalents for exchange with the environment. Unlike air-breathing vertebrates, which frequently utilize alterations of breathing (respiratory compensation) to regulate acid-base ...
Cohen Yoni - - 2009
OBJECTIVES: The aim of this pilot study was to establish reference values for strong ion difference (SID) in umbilical cord blood and investigate the feasibility of evaluating fetal metabolism according to the comprehensive approach to acid-base abnormalities, based on Stewart's physiochemical theory. STUDY DESIGN: A prospective observational study. Women who ...
Kaplan Lewis J - - 2009
BACKGROUND: This study assesses if a physicochemical (PC) approach to acid-base balance improves the accuracy of acid-base diagnosis, and reduces inappropriate fluid loading. METHODS: Hundred consecutive patients with trauma admitted to a surgical intensive care unit at a level I trauma center were prospectively analyzed. Demographics, acid-base data and diagnoses, ...
Wagner Carsten A - - 2009
The renal collecting system serves the fine-tuning of renal acid-base secretion. Acid-secretory type-A intercalated cells secrete protons via a luminally expressed V-type H(+)-ATPase and generate new bicarbonate released by basolateral chloride/bicarbonate exchangers including the AE1 anion exchanger. Efficient proton secretion depends both on the presence of titratable acids (mainly phosphate) ...
Gödecke Tanja - - 2009
Earlier studies reported serotonergic activity for cimicifugic acids (CA) isolated from Cimicifuga racemosa. The discovery of strongly basic alkaloids, cimipronidines, from the active extract partition and evaluation of previously employed work-up procedures has led to the hypothesis of strong acid/base association in the extract. Re-isolation of the CAs was desired ...
Grudpan K - - 2009
A simple lab-on-chip approach with time-based detection is proposed. A platform is made from a piece of acrylic differently shaped channels for introducing sample and reagent(s) using flow manipulation. Time-based changes involving migration of the reaction zone are monitored. The changes can be visually monitored by using a stop-watch with ...
Ziyang Lou - - 2009
Chemical Oxygen Demand (COD) composition in landfill leachate would vary as the disposal time extended. Leachates with different ages were collected from Laogang Refuse Landfill of Shanghai, the largest landfill in China with a placement scale of 7600 t refuse per day. To characterize COD composition in leachate, samples were ...
Ceballos Claire - - 2009
Cationic nucleoside lipids based on a 3-nitropyrrole universal base were prepared from D-ribose using a straightforward chemical synthesis. Several studies including DLS, TEM, and ethidium bromide (EthBr) assay demonstrated that these amphiphilic molecules form supramolecular organizations of nanometer size in aqueous solutions and are able to bind nucleic acids. siRNA ...
Faustino Célia M C - - 2009
New anionic urea-based surfactants derived from alpha,omega-amino acids and in particular from beta-alanine were synthesized and their solution properties characterized by electrical conductivity, equilibrium surface tension, and steady-state fluorescence spectroscopy techniques. Double-chain surfactants and the single-chain surfactant containing a sulfate head group exhibited the lowest critical micelle concentration (cmc) values ...
Zamboni Nicola - - 2009
Stable isotope, and in particular (13)C-based flux analysis, is the exclusive approach to experimentally quantify the integrated responses of metabolic networks. Here we describe a protocol that is based on growing microbes on (13)C-labeled glucose and subsequent gas chromatography mass spectrometric detection of (13)C-patterns in protein-bound amino acids. Relying on ...
Shu Xiao-Li - - 2008
A metabolite profiling approach based on gas chromatography-mass spectrometry (GC-MS) was used to investigate time-dependent metabolic changes in the course of the germination of rice. Brown rice kernels were soaked and incubated for a total of 96 h under ambient conditions. Samples taken during the germination process were subjected to ...
Burns Darcy C - - 2008
An accurately measured equilibrium acid dissociation constant (pKa) is essential for understanding and predicting the fate of perfluorocarboxylic acids (PFCAs) in the environment. The aqueous pKa of perfluorooctanoic acid (PFOA) has been determined potentiometrically using a standard water-methanol mixed solvent approach and was found to be 3.8 +/- 0.1. The ...
Malgesini Beatrice - - 2009
Polyfluorinated N-alpha-Fmoc-is an element of-Boc-L-lysine represents the best-in-class among a set of polyfluorinated amino acids (PFAs) which are useful tools for (19)F NMR-Based Screening. In this communication, optimized reaction conditions that allowed for the multi-gram preparation of this unnatural amino acid are reported.
Braybrook Siobhan A - - 2008
Two fundamental aspects of plant development are the maturation phase of embryo development in seed plants and totipotency via somatic embryogenesis (SE). The LEAFY COTYLEDON (LEC) transcription factors (TFs) establish environments that promote cellular processes characteristic of the maturation phase and the initiation of somatic embryo formation. Based on recent ...
Morgan T J - - 2008
Fluid-induced metabolic acidosis can be harmful and can complicate cardiopulmonary bypass. In an attempt to prevent this disturbance, we designed a bicarbonate-based crystalloid circuit prime balanced on physico-chemical principles with a strong ion difference of 24 mEq/l and compared its acid-base effects with those of Plasma-Lyte 148, a multiple electrolyte ...
Antonopoulou Georgia - - 2008
A variety of 2-oxoamides and related amides based on natural and non-natural amino acids were synthesized. Their activity on two human intracellular phospholipases (GIVA cPLA(2) and GVIA iPLA(2)) and one human secretory phospholipase (GV sPLA(2)) was evaluated. We show that an amide based on (R)-gamma-norleucine is a highly selective inhibitor ...
Vrcek Ivana Vinković - - 2008
The values of Ka, DeltaSa, and DeltaHa for deprotonation of hydroxyurea (HU) and N-methylhydroxyurea (NMHU), as targeted compounds, and for betainohydroxamic acid, were potentiometrically determined. Although NMHU has two and HU even three deprotonation sites, the measurements confirm that they behave as weak acids with a single pK a approximately ...
Lawrence Gregory B - - 2008
Limited information is available on streams in the Adirondack region of New York, although streams are more prone to acidification than the more studied Adirondack lakes. A stream assessment was therefore undertaken in the Oswegatchie and Black River drainages; an area of 4585 km(2) in the western part of the ...
Gennari F John - - 2008
Disruption of normal gastrointestinal function as a result of infection, hereditary or acquired diseases, or complications of surgical procedures uncovers its important role in acid-base homeostasis. Metabolic acidosis or alkalosis may occur, depending on the nature and volume of the unregulated losses that occur. Investigation into the specific pathophysiology of ...
Popović Gordana - - 2009
Acid-base equilibria in homogeneous and heterogeneous systems of two antihistaminics, loratadine and desloratadine were studied spectrophotometrically in Britton-Robinson's buffer at 25 degrees C. Acidity constant of loratadine was found to be pK(a) 5.25 and those of desloratadine pK(a1) 4.41 and pK(a2) 9.97. The values of intrinsic solubilities of loratadine and ...
Franco Antonio - - 2008
The sorption of organic electrolytes to soil was investigated. A dataset consisting of 164 electrolytes, composed of 93 acids, 65 bases, and six amphoters, was collected from literature and databases. The partition coefficient log Kow of the neutral molecule and the dissociation constant pKa were calculated by the software ACD/Labs. ...
Anderson Kelly E - - 2008
Sulfuric acid and water clusters are important for new particle formation in the atmosphere. Recent experimental studies demonstrate that critical clusters in diverse atmospheric environments contain two acid molecules and may also include additional N-containing molecules (i.e., a base). We use first-principles molecular dynamics simulations to show that the presence ...
Verma Anita - - 2008
The cytotoxic activity of lethal factor (LF), a critical reagent used in the cell-based lethal toxin neutralization assay to assess anthrax vaccines, was shown to depend on the identity of its N-terminal amino acid, which plays a role in the targeting of LF to the proteasome for degradation. These results ...
Franzoi Ana Cristina - - 2009
Novel biosensors based on laccase from Aspergillus oryzae and the ionic liquids (ILs) 1-n-butyl-3-methylimidazolium hexafluorophosphate (BMIPF(6)) and 1-n-butyl-3-methylimidazolium tetrafluoroborate (BMIBF(4)) were constructed for determination of rosmarinic acid by square-wave voltammetry. The laccase catalyzes the oxidation of rosmarinic acid to the corresponding o-quinone, which is electrochemically reduced back to rosmarinic acid ...
Serra A - - 2009
Eighteen Massese male lambs, fed mainly maternal milk were slaughtered at 11, 14 and 17kg. Samples of Longissimus Dorsi (LD), Triceps Brachii (TB) and Semimembranosus (Sm) muscles were collected. Milk from the lamb's dams was sampled weekly. Fatty acid composition of milk and meat was determined. TB was the fattest ...
Glaubitz Sabine - - 2009
Marine pelagic redoxclines are zones of high dark CO(2) fixation rates, which can correspond up to 30% of the surface primary production. However, despite this significant contribution to the pelagic carbon cycle, the identity of most chemolithoautotrophic organisms is still unknown. Therefore, the aim of this study was to directly ...
Salles Frederico F - - 2008
The male imago of Americabaetis longetron Lugo-Ortiz & McCafferty is described based on nymphs reared on field in the municipality Alfredo Chaves, Espírito Santo state, Brazil. The species can be distinguished from the others male imagos of the genus by the following combination of characters: 1) turbinate eyes uniformly separated ...
Marabotti Anna - - 2008
Despite decades of investigations, it is not yet clear whether there are rules dictating the specificity of the interaction between amino acids and nucleotide bases. This issue was addressed by determining, in a dataset consisting of 100 high-resolution protein-DNA structures, the frequency and energy of interaction between each amino acid ...
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