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Xiong Meng M State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China. xujj@nju.edu.cn - - 2014
An ideal nanoporous poly(N-isopropylacrylamide) membrane has been fabricated in glass microchannels by means of spatially controlled photopatterning technology for a high level of enrichment and cleanup of nucleic acids.
Ou Keqin K Food Science and Human Nutrition Department, Institute of Food and Agricultural Sciences, University of Florida, Gainesville, Florida, 32611, United - - 2014
A major portion of ingested procyanidins are degraded by human microbiota in the colon into various phenolic compounds. These microbial metabolites are thought to contribute to the health benefits of procyanidins in vivo. The objective of this study was to identify and quantify the microbial metabolites of procyanidins after anaerobic ...
Labonté M-È ME Institute of Nutrition and Functional Foods, Laval University, Québec, Quebec, - - 2014
Background/objectives:We examined the prevalence of elevated plasma high-sensitivity C-reactive protein (hs-CRP) concentrations and associations with red blood cell (RBC) long-chain n-3 polyunsaturated fatty acids (LCn-3PUFA) in the James Bay Cree population from the province of Quebec (Canada).Subjects/methods:A total of 744 Cree adults (18-91 years) from seven communities of Eastern James ...
Chen Han-Yi HY School of Forest Resources and Environmental Sciences, Michigan Technological University, Houghton, 49931, USA Warnell School of Forestry and Natural Resources, University of Georgia, Athens, 30602, - - 2014
4-Coumarate:CoA ligase (4CL) catalyzes the formation of hydroxycinnamoyl-CoA esters for phenylpropanoid biosynthesis. Phylogenetically distinct Class I and Class II 4CL isoforms occur in angiosperms, and support lignin and non-lignin phenylpropanoid biosynthesis, respectively. In contrast, the few experimentally characterized gymnosperm 4CLs are associated with lignin biosynthesis and belong to the conifer-specific ...
Hu Zonglin Z Division of Molecular Biology, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, Laurel, Maryland 20708, - - 2014
Detection of nucleic acids using antibodies is uncommon. This is in part because nucleic acids are poor immunogens and it is difficult to elicit antibodies having high affinity to each type of nucleic acid while lacking cross-reactivity to others. We describe the origins and applications of a variety of anti-nucleic ...
Liu Zhiguo Z State Key Laboratory of Biocontrol School of Life Sciences, Sun Yat-Sen University, Guangzhou, 510006, People's Republic of - - 2014
Xylanase gene xynB, cellulase genes egxA and bgl4 were subjected to codon optimisation using two opposing strategies. One was designated the 'one amino acid-one codon' approach, which employs only the codon most used by humans for each amino acid. The other one is referred to as the "humanised" codon usage ...
Watanabe Kohei - - 2014
Allylic arylation of cinnamyloxyphenylboronic acid pinacol esters 3, which have aryl boronic acid moiety and allylic ether moiety, using a hydrazone 1d-Pd(OAc)2 system proceeded and gave corresponding 1,3-diarylpropene derivatives 4 with phenolic hydroxyl group by coupling reaction of π-allyl intermediate to boron-substituted position of leaving group selectively.
Venkataraman Harini H AIMMS Division of Molecular Toxicology, Department of Chemistry and Pharmaceutical sciences, Vrije Universiteit, De Boelelaan 1083, 1081 HV Amsterdam, The - - 2014
Cytochrome P450 BM3 mutants are promising biocatalysts for the production of drug metabolites. In the present study, the ability of cytochrome P450 BM3 mutants to produce oxidative metabolites of structurally related NSAIDs meclofenamic acid, mefenamic acid and tolfenamic acid was investigated. A library of engineered P450 BM3 mutants was screened ...
Wang Ting-Ting TT College of Chemical Engineering, Ningbo University of Technology, Ningbo, 315016, China, - - 2014
A novel ionic liquid-modified organic-polymer monolithic capillary column was prepared and used for in-tube solid-phase microextraction (SPME) of acidic food additives. The primary amino group of 1-aminopropyl-3-methylimidazolium chloride was reacted with the epoxide group of glycidyl methacrylate. The as-prepared new monomer was then copolymerized in situ with acrylamide and N,N'-methylenebisacrylamide ...
Feng Chao C Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University , Singapore - - 2014
Rh(III)-catalyzed umpolung amidation of alkenylboronic acids for the synthesis of enamides is reported. This reaction proceeds readily at room temperature and displays an extremely wide spectrum of functional group tolerance. With cooperation of hydroboration, it enables the formal anti-Markovnikov hydroamidation of terminal alkynes, stereospecifically affording the trans-enamides in excellent yields.
Barber Janet E B JE Department of Chemistry & Centre for Catalysis Research and Innovation, University of Ottawa, Ottawa, Ontario, - - 2014
D-Amino acid aminotransferase (DAAT) catalyzes the synthesis of numerous D-amino acids, making it an attractive biocatalyst for the production of enantiopure D-amino acids. To bolster its biocatalytic applicability, improved variants displaying increased activity towards non-native substrates are desired. Herein, we report the development of a high-throughput, colorimetric, continuous coupled enzyme ...
Badoud Flavia - - 2014
A subgroup of obese individuals, referred to as metabolically healthy obese (MHO), have preserved insulin sensitivity and a normal lipid profile despite being obese. The molecular basis for this improved cardiometabolic profile remains unclear. Our objective was to integrate metabolite and gene expression profiling to elucidate the molecular distinctions between ...
Knipe Peter C PC Department of Chemistry, University of Oxford, Chemistry Research Laboratory, 12 Mansfield Road, Oxford, OX1 3TA, UK. - - 2014
A high-yielding and diastereoselective route to biologically significant 2-aryl- and 2-alkyl-3-amido dihydroquinolones has been developed in up to 90 : 10 e.r. by employing a novel Lewis acidic BINOL-derived copper(ii) catalyst.
Fakhoury H A HA Department of Basic Sciences, College of Science and Health Professions, King Saud bin Abdulaziz University for Health Sciences, National Guard Health Affairs, Riyadh, Saudi - - 2014
Two new HLA- DRB1 alleles were identified by sequence-based typing method (SBT) in 1100 participants in the Saudi Stem Cell Donor Registry. HLA-DRB1*11:150 differs from HLA-DRB1*11:01:01G by a single C to A substitution at nucleotide position 5580 in exon 2, resulting in an amino acid change from alanine to glutamic ...
Min Y Y Lipidomics and Nutrition Research Centre, Faculty of Life Sciences and Computing, London Metropolitan - - 2014
To test if docosahexaenoic acid-enriched fish oil supplementation rectifies red cell membrane lipid anomaly in pregnant women with Type 2 diabetes and their neonates, and alters fetal body composition. Women with Type 2 diabetes (n = 88; 41 fish oil, 47 placebo) and healthy women (n = 85; 45 fish oil, 40 placebo) were supplemented from ...
Wijnands José M A JM Division of Rheumatology, Department of Medicine, Maastricht University Medical Center, School for Public Health and Primary Care (CAPHRI), Maastricht University, CARIM School for Cardiovascular Diseases, Maastricht University, Department of Epidemiology, Maastricht University, Department of Internal Medicine, Maastricht University Medical Centre, Department of Clinical Epidemiology and Medical Technology Assessment, Maastricht University Medical Centre, Maastricht and Department of Human Nutrition, Wageningen University, Wageningen, The Netherlands.Division of Rheumatology, Department of Medicine, Maastricht University Medical Center, School for Public Health and Primary Care (CAPHRI), Maastricht University, CARIM School for Cardiovascular Diseases, Maastricht University, Department of Epidemiology, Maastricht University, Department of Internal Medicine, Maastricht University Medical Centre, Department of Clinical Epidemiology and Medical Technology Assessment, Maastricht University Medical Centre, Maastricht and Department of Human Nutrition, Wageningen University, Wageningen, The Netherlands. - - 2014
The aims of this study were to investigate (i) associations between uric acid and prevalent cardiovascular disease (CVD), ankle-arm blood pressure index (AAIx) and carotid intima-media thickness (CIMT) in the total population and in predefined subgroups according to glucose metabolism status and (ii) the extent to which these associations are ...
He Leiliang L State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Key Laboratory for Bio-Nanotechnology and Molecular Engineering of Hunan Province, Hunan University, Changsha 410082, China. - - 2014
We present a novel strategy for construction of a conformational switch of a molecular beacon based on the combination of nucleic acid (DNA) self-assembly and reversible host-guest inclusion interaction. With the functionalized probe, the nucleic acid hybridization process can be easily controlled with a photoactivated and thermal regeneration mode.
Koppolu Srinivasa Rao - - 2014
Direct alpha-alkylation of unactivated ketones using benzylic alcohols as electrophiles has been achieved at room temperature. This reaction takes place via in situ formed acetal using triflic acid and trimethyl orthoformate. It is believed that methyl vinyl ether formed from the in situ generated dimethyl acetal in the presence of ...
Cui-Ping Zhang Z College of Animal Sciences, Zhejiang Univ, Nr. 866 Yuhangtang Road, Hangzhou, 310058, - - 2014
A RP-high-performance liquid chromatography (HPLC) method was developed for quality control of Chinese propolis by simultaneous analysis of 12 flavonoids and 8 phenolic acids. The results showed that vanillic acid, rutin, myricetin, and luteolin were not detected in all of the analyzed propolis and poplar tree gum samples. The caffeic ...
Doberstein Christina C Institut für Molekulare Mikrobiologie und Biotechnologie, Westfälische Wilhelms-Universität Münster, D-48149 Münster, - - 2014
Ralstonia eutropha H16 is capable of utilizing 3,3'-thiodipropionic acid (TDP) and 3,3'-dithiodipropionic acid (DTDP) as precursor substrates for biosynthesis of a polythioester (PTE) heteropolymer consisting of 3-hydroxybutyric acid (3HB) and 3-mercaptopropionic acid (3MP). To elucidate the hitherto unknown catabolic pathways of TDP and DTDP in R. eutropha H16, 19 defined ...
Sudheep Naga M NM Department of Plant Science, School of Biological Sciences, Central University of Kerala, Riverside Campus, Padnekkad Nileswaram 671 328, Kerala, - - 2014
This study provides the nutritional qualities of two wild mushrooms (Agaricus abruptibulbus and Termitomyces globulus) commonly consumed by the tribals of Kaiga forests of the Western Ghats of India. Both mushrooms composed of high quantity of crude protein, crude fibre, calorific value and low quantity of crude lipid. Potassium and ...
Itahana Y Y Cancer & Stem Cell Biology Program, Duke-NUS Graduate Medical School Singapore, Singapore, - - 2014
Only humans and higher primates have high uric acid blood levels. Although high uric acid causes gout, it has been linked with human longevity because of its hypothetical antioxidant function. Recent studies reveal that p53 has significant roles in cellular metabolism. One example of this is an antioxidant function that ...
Park Sang Wook - - 2014
Human rhinoviruses (HRVs) are responsible for more than half of all cases of the common cold and cause billions of USD annually in medical visits and school and work absenteeism. An assessment was made of the cytotoxic and antiviral activities and possible mode of action of the tannin ellagic acid ...
Gorina Svetlana S SS Kazan Institute of Biochemistry and Biophysics, Russian Academy of Sciences, P.O. Box 30, 420111 Kazan, - - 2014
Enzymes of the CYP74 family, including the divinyl ether synthase (DES), play important roles in plant cell signalling and defence. The potent DES activities have been detected before in the leaves of the meadow buttercup (Ranunculus acris L.) and few other Ranunculaceae species. The nature of these DESs and their ...
Roesle Philipp P Department of Chemistry, University of Konstanz, 78464 Konstanz - - 2014
Current efforts to technically use microalgae focus on the generation of fuels with a molecular structure identical to crude oil based products. Here we suggest a different approach for the utilization of algae by translating the unique molecular structures of algae oil fatty acids into higher value chemical intermediates and ...
Lozano Blanca B Department of Nutrition and Food Science, Faculty of Pharmacy, University of Barcelona , Barcelona , Spain - - 2014
Abstract Although freezing is the most common method used to preserve human milk, nutritional and immunological components may be lost during storage. Freeze-drying could increase the shelf life of human milk, while preserving its original characteristics. Seventy-two samples of freeze-dried human milk were stored for different periods of time, up ...
Nakatsuji Hidefumi H Graduate School of Engineering, Nagoya University, Furo-cho, Chikusa, Nagoya 464-8603 (Japan) - - 2014
Chiral triaryl phosphates promote the enantioselective iodolactonization of 4-substituted 4-pentenoic acids to give the corresponding iodolactones in high yields with high enantioselectivity. N-Chlorophthalimide (NCP) is employed as a Lewis acidic activator and oxidant of I2 for the present iodolactonization. In combination with 1.5 equivalents of NCP, only 0.5 equivalents of ...
Ibáñez-Salazar Alejandro A Laboratorio de Biofarmacéuticos - - 2014
The high demand for less polluting, newer, and cheaper fuel resources has increased the search of the most innovative options for the production of the so-called biofuels. Chlamydomonas reinhardtii is a photosynthetic unicellular algae with multiple biotechnological advantages such as easy handling in the laboratory, a simple scale-up to industrial ...
Pang Shao-Chen SC State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, 430072, - - 2014
Omega-3 long-chain polyunsaturated fatty acid (n-3 LC-PUFA), especially eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are essential nutrients for human health. However, vertebrates, including humans, have lost the abilities to synthesize EPA and DHA de novo, majorly due to the genetic absence of delta-12 desaturase and omega-3 desaturase genes. Fishes, ...
Bhuiyan Mohammad M School of Science and Technology, University of New England, Armidale, NSW, 2351, - - 2014
The fatty acid profiles of Antarctic (n = 7) and non-Antarctic yeasts (n = 7) grown at different temperatures were analysed by gas chromatography-mass spectrometry. The Antarctic yeasts were enriched in oleic 18:1 (20-60 %), linoleic 18:2 (20-50 %) and linolenic 18:3 (5-40 %) acids with lesser amounts of palmitic 16:0 (<15 %) and palmitoleic 16:1 (<10 %) acids. ...
Brühlmann Fredi F Firmenich SA, Corporate R&D, Route des Jeunes 1, CH-1211 Geneva 8, Switzerland. Electronic address: - - 2014
Directed evolution via iterative cycles of random and targeted mutagenesis was applied to the P450 domain of the subterminal fatty acid hydroxylase CYP102A1 of B. megaterium to shift its regioselectivity towards the terminal position of palmitic acid. A powerful and versatile high throughput assay based on LC-MS allowed the simultaneous ...
Zheng Peizhong P Dow AgroSciences LLC, 9330 Zionsville Road, Indianapolis, IN, 46268, USA, - - 2014
We identified a G-nucleotide insertion in a maize FatB responsible for reducing saturated fatty acids through QTL mapping and map-based cloning and developed an allele-specific DNA marker for molecular breeding. Vegetable oils with reduced saturated fatty acids have signficant health benefits. SRS72NE, a Dow AgroSciences proprietory maize inbred line, was ...
Ratjen Lars L Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, 45470 Mülheim an der Ruhr - - 2014
The combination of Lewis acid organocatalysis and internal hydrogen-bond assistance was used to develop a new type of highly active disulfonimide catalyst. The increased Lewis acidity was documented by activity comparisons as well as theoretical investigations. Finally, the potential of the hydrogen-bond-assisted disulfonimide catalyst was demonstrated by its application in ...
Tan Guanhai G Key Laboratory of Chemical Biology of Hebei Province, College of Chemistry and Environmental Science, Hebei University, Baoding 071002, - - 2014
Novel dimers of triphenylethylene-coumarin hybrid containing one amino side chain were designed and synthesized by the condensation of four dicarboxylic acids with the amino monomeric hybrids catalyzed by HATU and DIPEA at room temperature. The adding order of the reactants had a significant effect on the condensation reaction when the ...
Larsen Sofus C - - 2014
Cross-sectional data suggests that a low level of plasma ascorbic acid positively associates with both Body Mass Index (BMI) and Waist Circumference (WC). This leads to questions about a possible relationship between dietary intake of ascorbic acid and subsequent changes in anthropometry, and whether such associations may depend on genetic ...
Maria John K M KM Department of Bioresources and Food Science, Konkuk University, Seoul 143-701, South - - 2014
Secondary metabolic variation of wild apple (Malus prunifolia) was compared with fruits that contained high flavan-3-ol like grapes (GR), apple (App) and the beverage, black tea (BT). The polyphenol contents in wild apple was higher than in GR and App but less than BT. The identified phenolic acids (gallic, protocatechuic, ...
Li Ning N Southern Institute of Pharmaceutical Research, South China Normal University, Guangzhou, 510631, China ; School of Information and Optoelectronic Science and Engineering, South China Normal University, Guangzhou, 510006, - - 2014
Confocal Raman microspectroscopy is a valuable analytical tool in biological and medical research, allowing the detection of sample variations without external labels or extensive preparation. To determine whether this method can assess the effect of maleic acid on sperm, we prepared human sperm samples incubated in different concentrations of maleic ...
Bauman Julie J University of Pittsburg Cancer Institute, Pittsburgh, - - 2014
Smokers experience aberrant gene promoter methylation in their bronchial cells, which may predispose to the development of neoplasia. Hydralazine is a DNA demethylating agent, and valproic acid is a histone deacetylase inhibitor, and both have modest but synergistic anticancer activity in vitro. We conducted a phase I trial combining valproic ...
Zhang Yifeng Y Key Laboratory of Pollution Processes and Environmental Criteria, Ministry of Education, College of Environmental Science and Engineering, Nankai University, Tianjin 300071, PR - - 2014
A total of 100 serum samples from 50 new couples (none of the females in this study has ever been pregnant) in Tianjin, North China, were analyzed for eleven perfluoroalkyl acids (PFAAs) with isomer-specific method. Among all samples, total perfluorooctanesulfonate (∑PFOS, mean 11.3ng/mL) was predominant followed by total perfluorooctanoate (∑PFOA, ...
Yoon Sangeun - - 2014
The palladium-catalyzed coupling of N,N-ditosylbenzylamines with arylboronic acids has been investigated, and the resulting diarylmethanes were obtained in high yields. Conversion of the amine to a N,N-ditosylimide group provided an efficient leaving group for the Pd-catalyzed benzylation of arylboronic acids.
Daley Clare C 1 Nutrition and Dietetics, School of Health Sciences, University of Newcastle, Hunter Building, University Drive, Callaghan, NSW 2308, - - 2014
To determine if associations exist between a range of unsaturated fatty acid intakes and mental health outcomes. Cross-sectional data analysis of the Australian Longitudinal Study on Women's Health (ALSWH) Young Cohort Survey 3 that included the validated seventy-four-item Dietary Questionnaire for Epidemiological Studies FFQ, validated mental health scales and self-report ...
Oliveira Lilian C G LC Departamento de Biofísica, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, - - 2014
The substrate specificity of TcoCBc1 was evaluated using two internally quenched fluorescent peptide libraries with randomized sequences designed to detect carboxydipeptidase (Abz-GXXZXK(Dnp)-OH) and endopeptidase (Abz-GXXZXXQ-EDDnp) activities at acidic and neutral pHs, respectively. All the data obtained with TcoCBc1 were compared with those of human cathepsin B, including the pH profiles ...
Sims Steven R - - 2014
Topical and fumigant toxicity of saturated aliphatic fatty acids with chain lengths of C1 through C14 were determined against the German cockroach, Blattella germanica (L.). In the C1 to C11 series, topical toxicity (LD50 in milligram per adult male) ranged from 0.145 (C1) to 0.322 mg (C2). Toxicity declined dramatically ...
Brooklyin Sivakumar S Department of Anatomy, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER) , - - 2014
Studies have identified the risk factors like folic acid deficiency during gestational period, family history for orofacial clefts, drugs like antiepileptic, vitamin A. But, the data regarding the folic acid status in children with cleft lip/palate is hardly evaluated in depth. Here, an assessment of folic acid and DNA damage ...
Suchy Mojmir - - 2014
A synthesis of an intrinsically fluorescent cytosine analog 5,6-benzopC has been developed utilizing the reductive Ni-mediated cyclization of an N4-aryl, N4-(Boc)cytosine intermediate as a key step. 5,6-BenzopC was found to possess interesting fluorescence properties (Φ = 0.79, EtOH; Stoke's shift 113 nm). Peptide nucleic acid (PNA) oligomerization of the 5,6-benzopC ...
Chen Wei W Department of Food Science and Technology, The University of Tennessee, 2510 River Drive, Knoxville, TN, 37996-4539, - - 2014
The purpose of this study was to investigate the difference in expression of fatty acid biosynthesis genes and survival of different serotypes of Salmonella when incubated in a low water activity (aw ) food over a 14-d period. Stationary cells of five strains of Salmonella enterica belonging to 3 different ...
Mazur Sebastian Piotr SP Bioforsk, Norwegian Institute for Agricultural and Environmental Research, N-1432 Ås, Norway; Department of Plant Sciences, Norwegian University of Life Sciences, P.O. Box 5003, N-1432 Ås, Norway. Electronic address: - - 2014
Colour and chemical composition of fruits of 10 red raspberry genotypes grown in Nordic climate during three harvest seasons were studied. The main phenolic compounds in the fruits were ellagitannins and anthocyanins, contributing 57% and 42% to the quantified phenolic compounds, respectively. Cyanidin-3-sophoroside was the most abundant anthocyanin (61%). All ...
Torelli Emanuela E Department of Agricultural and Environmental Sciences, University of Udine, via delle Scienze 206, 33100, Udine, - - 2014
A prototype for a DNA origami nanorobot has been designed, produced and tested. The cylindrical nanorobot (diameter of 14 nm and length of 48 nm) with a switchable flap, is able to respond to an external stimulus and reacts by a physical switch from a disarmed to an armed configuration ...
Santos S S Institute of Public Health, University of Porto, Porto, - - 2014
Background/objectives:Evidence on the association between fatty acids and adiponectin and leptin concentrations is scarce and inconsistent, which may in part be due to limitations of dietary reporting methods. We aimed to estimate the association of fatty acids, derived from a food frequency questionnaire (FFQ) and measured in the erythrocyte membrane, ...
Midttun Oivind O Bevital, Bergen, - - 2014
Knowledge of stability during sample transportation and changes in biomarker concentrations within person over time are paramount for proper design and interpretation of epidemiologic studies based on a single measurement of biomarker status. Therefore, we investigated stability and intraindividual vs. interindividual variation in blood concentrations of biomarkers related to vitamin ...
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