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Zheng Peizhong P Dow AgroSciences LLC, 9330 Zionsville Road, Indianapolis, IN, 46268, USA, - - 2014
We identified a G-nucleotide insertion in a maize FatB responsible for reducing saturated fatty acids through QTL mapping and map-based cloning and developed an allele-specific DNA marker for molecular breeding. Vegetable oils with reduced saturated fatty acids have signficant health benefits. SRS72NE, a Dow AgroSciences proprietory maize inbred line, was ...
Ratjen Lars L Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, 45470 Mülheim an der Ruhr - - 2014
The combination of Lewis acid organocatalysis and internal hydrogen-bond assistance was used to develop a new type of highly active disulfonimide catalyst. The increased Lewis acidity was documented by activity comparisons as well as theoretical investigations. Finally, the potential of the hydrogen-bond-assisted disulfonimide catalyst was demonstrated by its application in ...
Tan Guanhai G Key Laboratory of Chemical Biology of Hebei Province, College of Chemistry and Environmental Science, Hebei University, Baoding 071002, - - 2014
Novel dimers of triphenylethylene-coumarin hybrid containing one amino side chain were designed and synthesized by the condensation of four dicarboxylic acids with the amino monomeric hybrids catalyzed by HATU and DIPEA at room temperature. The adding order of the reactants had a significant effect on the condensation reaction when the ...
Larsen Sofus C - - 2014
Cross-sectional data suggests that a low level of plasma ascorbic acid positively associates with both Body Mass Index (BMI) and Waist Circumference (WC). This leads to questions about a possible relationship between dietary intake of ascorbic acid and subsequent changes in anthropometry, and whether such associations may depend on genetic ...
Maria John K M KM Department of Bioresources and Food Science, Konkuk University, Seoul 143-701, South - - 2014
Secondary metabolic variation of wild apple (Malus prunifolia) was compared with fruits that contained high flavan-3-ol like grapes (GR), apple (App) and the beverage, black tea (BT). The polyphenol contents in wild apple was higher than in GR and App but less than BT. The identified phenolic acids (gallic, protocatechuic, ...
Li Ning N Southern Institute of Pharmaceutical Research, South China Normal University, Guangzhou, 510631, China ; School of Information and Optoelectronic Science and Engineering, South China Normal University, Guangzhou, 510006, - - 2014
Confocal Raman microspectroscopy is a valuable analytical tool in biological and medical research, allowing the detection of sample variations without external labels or extensive preparation. To determine whether this method can assess the effect of maleic acid on sperm, we prepared human sperm samples incubated in different concentrations of maleic ...
Bauman Julie J University of Pittsburg Cancer Institute, Pittsburgh, - - 2014
Smokers experience aberrant gene promoter methylation in their bronchial cells, which may predispose to the development of neoplasia. Hydralazine is a DNA demethylating agent, and valproic acid is a histone deacetylase inhibitor, and both have modest but synergistic anticancer activity in vitro. We conducted a phase I trial combining valproic ...
Zhang Yifeng Y Key Laboratory of Pollution Processes and Environmental Criteria, Ministry of Education, College of Environmental Science and Engineering, Nankai University, Tianjin 300071, PR - - 2014
A total of 100 serum samples from 50 new couples (none of the females in this study has ever been pregnant) in Tianjin, North China, were analyzed for eleven perfluoroalkyl acids (PFAAs) with isomer-specific method. Among all samples, total perfluorooctanesulfonate (∑PFOS, mean 11.3ng/mL) was predominant followed by total perfluorooctanoate (∑PFOA, ...
Yoon Sangeun - - 2014
The palladium-catalyzed coupling of N,N-ditosylbenzylamines with arylboronic acids has been investigated, and the resulting diarylmethanes were obtained in high yields. Conversion of the amine to a N,N-ditosylimide group provided an efficient leaving group for the Pd-catalyzed benzylation of arylboronic acids.
Daley Clare C 1 Nutrition and Dietetics, School of Health Sciences, University of Newcastle, Hunter Building, University Drive, Callaghan, NSW 2308, - - 2014
To determine if associations exist between a range of unsaturated fatty acid intakes and mental health outcomes. Cross-sectional data analysis of the Australian Longitudinal Study on Women's Health (ALSWH) Young Cohort Survey 3 that included the validated seventy-four-item Dietary Questionnaire for Epidemiological Studies FFQ, validated mental health scales and self-report ...
Oliveira Lilian C G LC Departamento de Biofísica, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, - - 2014
The substrate specificity of TcoCBc1 was evaluated using two internally quenched fluorescent peptide libraries with randomized sequences designed to detect carboxydipeptidase (Abz-GXXZXK(Dnp)-OH) and endopeptidase (Abz-GXXZXXQ-EDDnp) activities at acidic and neutral pHs, respectively. All the data obtained with TcoCBc1 were compared with those of human cathepsin B, including the pH profiles ...
Sims Steven R - - 2014
Topical and fumigant toxicity of saturated aliphatic fatty acids with chain lengths of C1 through C14 were determined against the German cockroach, Blattella germanica (L.). In the C1 to C11 series, topical toxicity (LD50 in milligram per adult male) ranged from 0.145 (C1) to 0.322 mg (C2). Toxicity declined dramatically ...
Brooklyin Sivakumar S Department of Anatomy, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER) , - - 2014
Studies have identified the risk factors like folic acid deficiency during gestational period, family history for orofacial clefts, drugs like antiepileptic, vitamin A. But, the data regarding the folic acid status in children with cleft lip/palate is hardly evaluated in depth. Here, an assessment of folic acid and DNA damage ...
Suchy Mojmir - - 2014
A synthesis of an intrinsically fluorescent cytosine analog 5,6-benzopC has been developed utilizing the reductive Ni-mediated cyclization of an N4-aryl, N4-(Boc)cytosine intermediate as a key step. 5,6-BenzopC was found to possess interesting fluorescence properties (Φ = 0.79, EtOH; Stoke's shift 113 nm). Peptide nucleic acid (PNA) oligomerization of the 5,6-benzopC ...
Chen Wei W Department of Food Science and Technology, The University of Tennessee, 2510 River Drive, Knoxville, TN, 37996-4539, - - 2014
The purpose of this study was to investigate the difference in expression of fatty acid biosynthesis genes and survival of different serotypes of Salmonella when incubated in a low water activity (aw ) food over a 14-d period. Stationary cells of five strains of Salmonella enterica belonging to 3 different ...
Mazur Sebastian Piotr SP Bioforsk, Norwegian Institute for Agricultural and Environmental Research, N-1432 Ås, Norway; Department of Plant Sciences, Norwegian University of Life Sciences, P.O. Box 5003, N-1432 Ås, Norway. Electronic address: - - 2014
Colour and chemical composition of fruits of 10 red raspberry genotypes grown in Nordic climate during three harvest seasons were studied. The main phenolic compounds in the fruits were ellagitannins and anthocyanins, contributing 57% and 42% to the quantified phenolic compounds, respectively. Cyanidin-3-sophoroside was the most abundant anthocyanin (61%). All ...
Torelli Emanuela E Department of Agricultural and Environmental Sciences, University of Udine, via delle Scienze 206, 33100, Udine, - - 2014
A prototype for a DNA origami nanorobot has been designed, produced and tested. The cylindrical nanorobot (diameter of 14 nm and length of 48 nm) with a switchable flap, is able to respond to an external stimulus and reacts by a physical switch from a disarmed to an armed configuration ...
Santos S S Institute of Public Health, University of Porto, Porto, - - 2014
Background/objectives:Evidence on the association between fatty acids and adiponectin and leptin concentrations is scarce and inconsistent, which may in part be due to limitations of dietary reporting methods. We aimed to estimate the association of fatty acids, derived from a food frequency questionnaire (FFQ) and measured in the erythrocyte membrane, ...
Midttun Oivind O Bevital, Bergen, - - 2014
Knowledge of stability during sample transportation and changes in biomarker concentrations within person over time are paramount for proper design and interpretation of epidemiologic studies based on a single measurement of biomarker status. Therefore, we investigated stability and intraindividual vs. interindividual variation in blood concentrations of biomarkers related to vitamin ...
Khan Zaigham Mahmood ZM Interfaculty Institute of Biochemistry, University of Tuebingen, Tuebingen, - - 2014
Human polyomavirus 9 (HPyV9) is a closely related homologue of simian B-lymphotropic polyomavirus (LPyV). In order to define the architecture and receptor binding properties of HPyV9, we solved high-resolution crystal structures of its major capsid protein, VP1, in complex with three putative oligosaccharide receptors identified by glycan microarray screening. Comparison ...
Hwang Jinil - - 2014
Trifluoroethylation of alkyne was developed through the palladium-catalyzed decarboxylative coupling reaction. When akynyl carboxylic acids and ICH2CF3 were allowed to react with [Pd(η3-allyl)Cl]2/XantPhos and Cs2CO3 in N,N-dimethyl formamide (DMF) at 80 degC for 1 h, the desired products were formed in good yields. This catalytic system showed high functional group ...
Stowers Chris C CC Dow AgroSciences, LLC., 9330 Zionsville Road, Indianapolis, IN, 46268, USA, - - 2014
Propionic acid (PA) is a short-chain fatty acid with wide industrial application including uses in pharmaceuticals, herbicides, cosmetics, and food preservatives. As a three-carbon building block, PA also has potential as a precursor for high-volume commodity chemicals such as propylene. Currently, most PA is manufactured through petrochemical routes, which can ...
Adepu Raju R Dr Reddy's Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad 500 046, India. - - 2014
A Cu-catalyzed new sequence involving the Ullmann type intermolecular C-C followed by an intramolecular C-N coupling and then intramolecular aza-Michael type addition (and oxidation) in a single pot afforded various fused N-heterocyclic acetic acid derivatives as inhibitors of PDE4.
Wan Wei W Department of Chemistry, Texas A&M University, College Station, TX 77845, - - 2014
The genetic incorporation of the 22nd proteinogenic amino acid, pyrrolysine (Pyl) at amber codon is achieved by the action of pyrrolysyl-tRNA synthetase (PylRS) together with its cognate tRNA(Pyl). Unlike most aminoacyl-tRNA synthetases, PylRS displays high substrate side chain promiscuity, low selectivity toward its substrate α-amine, and low selectivity toward the ...
Enard David D Stanford - - 2014
The role of positive selection in human evolution remains highly controversial. On the one hand, scans for positive selection have identified hundreds of candidate loci and the genome-wide patterns of polymorphism show signatures consistent with frequent positive selection. On the other hand, recent studies have argued that many of the ...
Marconi Ombretta O Dept. of Agricultural, Food and Environmental Science, Univ. of Perugia, Via san Costanzo, 06126, Perugia, - - 2014
High consumption of saturated fatty acids (SFA) is associated with increased risk of cardiovascular disease and the European Food Safety Agency has called for lower SFA intake. This study assessed the formulation of low SFA shortbreads by replacing 60% and 70% of the butter content with high oleic sunflower oil ...
Bradbeer Jennifer F JF Department of Chemical Engineering, University of Birmingham, Edgbaston, Birmingham B15 2TT, - - 2014
This study investigated the in vitro acid-induced gelation of mixed systems of two biopolymers; low acyl and high acyl gellan gum. Rheological and texture analysis showed that these mixed gels displayed textures that lay between the material properties exhibited for the low and high acyl variants. DSC analysis showed that mixtures ...
Wu Yuqiang Y Laboratory of Nanophotonics and Biosensing, Max Planck Insitute for the Science of Light, Erlangen, 91058, - - 2014
Nucleic acid detection with label-free biosensors circumvents costly fluorophore functionalization steps associated with conventional assays by utilizing transducers of impressive ultimate detection limits. Despite this technological prowess, molecular recognition at a surface limits the biosensors' sensitivity, specificity, and reusability. It is therefore imperative to integrate novel molecular approaches with existing ...
Gu Sol-A SA Department of Chemical Engineering, Kwangwoon University, Seoul 139-701, Republic of - - 2014
Lactobacillus coryniformis is known to produce d-lactic acid as a dominant fermentation product at a cultivation temperature of approximately 30°C. However, the considerable production of l-lactic acid is observed when the fermentation temperature is greater than 40°C. Because optically pure lactates are synthesized from pyruvate by the catalysis of chiral-specific ...
Porto Carla Da CD Department of Food Science, University of Udine, Udine, - - 2014
ABSTRACT The cultivation of four industrial hemp cultivars (Felina 32, Chamaeleon, Uso31, and Finola) was investigated for oil production in the north-east of Italy along two years. The oils of all cultivars resulted in rich amount of linoleic acid (ω-6) and α-linolenic acid (ω-3). Felina 32 and Chamaeleon oils exhibited ...
Li Qianbiao Q CAS Key Laboratory of Soft Matter Chemistry, Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei, P. R. China 230026. - - 2014
A facile one pot strategy for the preparation of linear and hyperbranched polyacrylates has been successfully developed by the combination of in situ esterification of acrylic acid with halogenated compounds promoted by 1,1,3,3-tetramethylguanidine (TMG) and RAFT polymerization.
Ibeagha-Awemu Eveline M - - 2014
Fatty acid desaturase 1 (FADS1) and 2 (FADS2) genes code respectively for the enzymes delta-5 and delta-6 desaturases which are rate limiting enzymes in the synthesis of polyunsaturated omega-3 and omega-6 fatty acids (FA). Omega-3 and-6 FAs as well as conjugated linoleic acid (CLA) are present in bovine milk and ...
Tan Maria Carmen MC JST ERATO, Lipid Active Structure Project, Osaka University, 1-1 Machikaneyama, Toyonaka, Osaka 560-0043, Japan; Department of Chemistry, De La Salle University, 2401 Taft Avenue, Malate, Manila 1004, - - 2014
The role of heart-type fatty acid-binding protein (FABP3) in human physiology as an intracellular carrier of fatty acids (FAs) has been well-documented. In this study, we aimed to develop an analytical method to study real-time interaction kinetics between FABP3 immobilized on the sensor surface and unsaturated C18 FAs using surface ...
Bielecka Monika M Centre for Novel Agricultural Products, Department of Biology, University of York, York, - - 2014
We used expressed sequence tag library and whole genome sequence mining to identify a suite of putative desaturase genes representing the four main activities required for production of polyunsaturated fatty acids in hemp seed oil. Phylogenetic-based classification and developing seed transcriptome analysis informed selection for further analysis of one of ...
Saha Subhadeep S Physical and Materials Chemistry Division, CSIR-National Chemical Laboratory, Dr. Homi Bhabha Road, Pune 411008, India. - - 2014
A multiresponsive metallohydrogel based on an amino acid-derived low molecular weight (LMW) ligand and a Zn(ii) salt was prepared. This hydrogel showed remarkable shape-persistent, self-standing, load-bearing and self-healing properties, which is uncommon in LMW hydrogels.
Steiniger Sebastian C J SC Zoetis VMRD Global Therapeutics Research, 333 Portage Street, Kalamazoo, MI 49001, USA. Electronic address: - - 2014
Complementarity determining regions (CDR) are responsible for binding antigen and provide substantial diversity to the antibody repertoire, with VH CDR3 of the immunoglobulin variable heavy (VH) domain playing a dominant role. In this study, we examined 1200 unique canine VH and 500 unique variable light (VL) sequences of large and ...
Tao Yong Y Key Laboratory of Environmental and Applied Microbiology, CAS; Environmental Microbiology Key Laboratory of Sichuan Province, Chengdu Institute of Biology, Chinese Academy of Sciences, Sichuan, 610041, PR - - 2014
Chinese strong-flavor liquor (CSFL) accounts for more than 70% of all Chinese liquor production. Microbes in pit mud play key roles in the fermentation cellar for the CSFL production. However, microbial diversity, community structure and cellar-age-related changes in pit mud are poorly understood. Here, we investigated prokaryotic community structure and ...
Huang Tao T Department of Food Science and Nutrition, Zhejiang University, Hangzhou, China; Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, - - 2014
The aim of this study was to examine the association of the genetic variants in the fatty acid desaturase (FADS) gene cluster with erythrocyte phospholipid fatty acids (PLFA), and their relation to risk for type 2 diabetes mellitus (T2DM) in Han Chinese. Seven hundred and fifty-eight patients with T2DM and ...
Ullah Shahid S Department of Applied Environmental Science (ITM), Stockholm University, SE-106 91 Stockholm, - - 2014
A method was developed for simultaneous analysis of perfluoroalkane sulfonic acids (PFSAs) and their sulfonamide-based precursors (perfluoroalkane sulfonamidoacetic acids (FASAAs), sulfonamides (FASAs), and sulfonamidoethanols (FASEs)) in fish muscle. Extraction was performed with acetonitrile followed by a clean-up and fractionation step and instrumental analysis by UPLC/MS/MS and GC/MS. Time trends of ...
Feng Lin L Key Laboratory of Tea Biochemistry and Biotechnology, Anhui Agricultural University, 130 Changjiang Blvd West, Hefei, Anhui 230036, - - 2014
Albino tea has received increased attention due to its brisk flavour. To identify changes in the key chemical constituents conveying important qualities to albino tea, the metabolite profiles of four albino cultivars and one green tea cultivar were analysed. Compared to the green tea control, significantly decreased contents of chlorophyll ...
Sun Xianyu X Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, 20 Penn Street, Baltimore, Maryland 21201 ; College of Animal Science and Technique, Heilongjiang Bayi Agriculture University, Daqing 163319, Heilongjiang, PR - - 2014
1-(3-Oxocyclobutyl) carboxylic acid (4a) was converted into N-Boc-protected 1-(3-oxocyclobutyl) urea (5a), a key intermediates for the preparation of agonists of metabotropic glutamate receptor 5, in one-step when treated with diphenyl phosphoryl azide and triethylamine in tert-butanol. The mechanism of the reaction involves a nucleophilic addition of the in situ generated ...
Marshall L A LA Department of Chemical Engineering, Stanford University, - - 2014
We present a novel microchip device for purification of nucleic acids from 25μL biological samples using isotachophoresis (ITP). The device design incorporates a custom capillary barrier structure to facilitate robust sample loading. The chip uses a 2mm channel width and 0.15mm depth to reduce processing time, mitigate Joule heating, and ...
Axmon Anna A Department of Occupational and Environmental Medicine, Lund University, SE-221 85 Lund, Sweden. Electronic address: - - 2014
Perfluoroalkyl acids (PFAAs) are a large group of chemicals which are highly persistent in both nature and humans. The use of the most prominent ones, perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA), was reduced in the early 21st century, and since then levels in human matrices have decreased. However, these ...
Jaudszus Anke A Department of Physiology and Biochemistry of Nutrition, Max Rubner-Institut, Federal Research Institute of Nutrition and Food, Karlsruhe, Germany (AJ, MP, and AR), and the Department of Nutritional Physiology, Institute of Nutrition, Friedrich Schiller University of Jena, Jena, Germany (RK, GJ, and - - 2014
trans Palmitoleic acid (t-16:1n-7, or 16:1t9 in the δ nomenclature usually applied to trans fatty acids and used herein) arouses great scientific interest because it has been suggested to serve as a biomarker for lower risks of type 2 diabetes and coronary artery disease. Although 16:1t9 has been assumed to ...
Rijal Keshab K Department of Chemistry, Wayne State University, 5101 Cass Ave., Detroit, MI 48202, USA. - - 2014
Cisplatin can be modified with various ligands to alter the size and charge distribution of the complex. Several amino acid-linked platinum(ii) complexes were synthesized, and a reactivity study with 16S ribosomal RNA was carried out. The amino acid-linked analogues show altered specificity compared to the parental compound cisplatin.
Santos S S Histocompatibilidad, Centro Vasco de Transfusión y Tejidos Humanos, Galdacano, Vizcaya,, - - 2014
HLA-DRB1*11:153 differs from DRB1*11:131 by one nucleotide at position 286 where C > A, (codon 67 CTC>ATC), resulting in an amino acid substitution, 67L>67I.
Ayca Ozdemir Olgun F F Department of Chemistry, Faculty of Science and Letters, Istanbul Technical University, Ayazaga Maslak, 34469, Istanbul, - - 2014
This study proposes modifications to the conventional Folin-Ciocalteu (FC) spectrophotometric method for individually determining ascorbic acid (AA) in complex matrices in the presence of other phenolics and potential interferents. Conventional FC assay in aqueous phase normally measuring total water-soluble phenolics and other antioxidants has recently been modified by incorporating iso-butanol ...
Amiri-Jami Mitra M Department of Food Science, University of Guelph, Guelph, ON, Canada, - - 2014
Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have been shown to be of major importance in human health. Therefore, these essential polyunsaturated fatty acids have received considerable attention in both human and farm animal nutrition. Currently, fish and fish oils are the main dietary sources of EPA/DHA. To generate sustainable ...
Sun Chunming C Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences , Ningbo, 315201, - - 2014
We reported a significant improvement in the efficiency of organic solar cells by introducing hybrid TiO2:1,10-phenanthroline as a cathode buffer layer. The devices based on polymer thieno[3,4-b]thiophene/benzodithiophene:[6,6]-phenyl C71-butyric acid methyl ester (PTB7:PC71BM) with hybrid buffer layer exhibited an average power conversion efficiency (PCE) as high as 8.02%, accounting for 20.8% ...
Košiová Ivana I Institute of Organic Chemistry and Biochemistry, Academy of Sciences v. v. i., Flemingovo 2, 166 10 Prague 6, Czech - - 2014
A series of conformationally constrained uridine-based nucleoside phosphonic acids containing annealed 1,3-dioxolane and 1,4-dioxane rings and their "open-structure" isosteres were synthesized and evaluated as potential multisubstrate-like inhibitors of the human recombinant thymidine phosphorylase (TP, EC 2.4.2.4) and TP obtained from peripheral blood mononuclear cells (PBMC). From a large set of ...
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