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Yokokura Yoshiyuki Y Department of Health Chemistry, Business-Academia Collaborative Laboratory, Department of Integral Analytical Chemistry, Graduate School of Pharmaceutical Sciences, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan, and Laboratory for Metabolomics, RIKEN Center for Integrative Medical Sciences (IMS), 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa, Japan, and PRESTO, Japan Science and Technology Agency, 4-1-8 Honcho, Kawaguchi, Saitama, - - 2014
Docosahexaenoic acid (DHA) exhibits anti-inflammatory activity related to some of its oxygenated metabolites, such as D-series resolvins, protectin and maresin. Here, we analyzed the lipids in inflammatory exudates using liquid chromatography-tandem mass spectrometry (LC-MS/MS) and identified a novel DHA metabolite, 14,20-dihydroxy-docosahexaenoic acid (14,20-diHDHA) and showed that it is biosynthesized by ...
Baker Jacob J JJ Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI, - - 2014
During pathogenesis, Mycobacterium tuberculosis (Mtb) colonizes environments, such as the macrophage or necrotic granuloma, that are acidic and rich in cholesterol and fatty acids. The goal of this study was to examine how acidic pH and available carbon sources interact to regulate Mtb physiology. Here we report that Mtb growth ...
Vleggaar Danny - - 2014
Injection-related adverse events (AEs) may occur with the use of any injectable substance, including all commercially available fillers. The most common of these AEs include discomfort, bruising, edema, and erythema, which are generally transient and resolve spontaneously. The majority of AEs widely felt to be associated with poly-L-lactic acid (PLLA) ...
Akce Mehmet M Department of Internal Medicine, Saint Joseph Mercy Hospital, Ann Arbor, Michigan, MI 48106, - - 2014
A 67-year-old male presented with fatigue, abdominal pain , and 30-pound weight loss over 3 months. Computerized tomography (CT) abdomen displayed ascites with thickening and enhancement of the peritoneum and mottled nodular appearing as soft tissue consistent with omental caking worrisome for peritoneal carcinomatosis. A paracentesis revealed white blood cell ...
Lorenc Z Paul - - 2013
Belotero Balance is a novel highly cross-linked hyaluronic acid that uses cohesive polydensified matrix technology to achieve cohesive gel; improved adaptation by the dermis; and a soft, smooth fill. Several studies have now compared Belotero Balance to bovine collagen and other hyaluronic acids. Two pivotal studies demonstrated the noninferiority and ...
Hering Silvio - - 2013
Streptococcus pyogenes (group A Streptococcus, GAS) is an important human pathogen causing mild superficial infections of skin and mucous membranes, but also life-threatening systemic diseases. S. pyogenes and other prokaryotic organisms use the arginine deiminase system (ADS) for survival in acidic environments. In this study, the arginine deiminase (AD), and ...
Suzuki Toshinori - - 2013
Hypobromous acid (HOBr) is formed by eosinophil peroxidase and myeloperoxidase in the presence of H2O2, Cl(-), and Br(-) in the host defense system of humans, protecting against invading bacteria. However, the formed HOBr may cause damage to DNA and its components in the host. When a guanine nucleoside (3',5'-di-O-acetyl-2'-deoxyguansoine) was ...
Lee Sunhee - - 2013
Fatty acyl-acyl carrier protein (ACP) thioesterase (acyl-ACP TE) from Streptococcus pyogenes (strain MGAS10270) was codon-optimized and expressed in Escherichia coli K-12 W3110 and Escherichia coli K-12 MG1655. By employing codon-optimized S. pyogenes acyl-ACP TE to improve the total free fatty acids (FFAs) and to tailor the composition of FFAs, high-specificity ...
Miyata Jun - - 2012
BACKGROUND: Protectin D1 (PD1) is an anti-inflammatory and proresolving lipid mediator biosynthesized from the omega-3 fatty acid docosahexaenoic acid (DHA). Exogenous PD1 conferred protection against eosinophilic inflammation in animals with experimental asthma, although its endogenous cellular source and functions in human airways are of interest. OBJECTIVE: We sought to investigate ...
Kim Seon-Hee - - 2012
Fatty acids (FAs) are the main energy sources of living organisms and are the major components of cellular and organelle membranes. Their compositions also affect the flexibility/rigidity of cells and cell vitality. The Taenia solium metacestode (TsM) causes neurocysticercosis (NC), which is one of the most common helminthic infections of ...
Gabrielsen Mads - - 2012
As-p18 is a fatty-acid-binding protein from the parasitic nematode Ascaris suum. Although it exhibits sequence similarity to mammalian intracellular fatty-acid-binding proteins, it contains features that are unique to nematodes. Crystals were obtained, but initial diffraction data analysis revealed that they were composed of a number of `microdomains'. Interpretable data could ...
Wu Xiaowen - - 2012
The synthesis and chiral recognition properties of a porphyrin host with introverted functionality is reported. The host is a hybrid of tetraphenyl zinc porphyrin and the N-phenylamide derivative of (S)-nipecotic acid. The chiral recognition properties of the porphyrin host with chiral carboxylate-containing guests is described. UV/vis and (1)H NMR spectroscopic ...
Paakkonen Tommi - - 2012
The deer ked (Lipoptena cervi, Diptera, Hippoboscidae) is a haematophagous parasitic fly of the moose (Alces alces) and other cervids, and it is very common in southern and central parts of Finland. The aim of this study was to determine how the intensive parasitism caused by the deer ked affects ...
Joyce Leo A - - 2012
The association between an achiral copper(II)-containing host 1 and chiral carboxylates has been expanded beyond previous studies to new chiral carboxylate guests, both α-amino acids and β-homoamino acids. The observed exciton-coupled circular dichroism (ECCD) signals for the enantiomers of each carboxylate were equal and opposite, and these signals differed in ...
Fraga Carolina Miguel - - 2012
Human cysticercosis caused by Taenia crassiceps is rare however it is considered of zoonotic risk. The treatment of the infected patients was successful when using albendazole or praziquantel. The active forms of albendazole inhibit the glucose uptake and the active forms of praziquantel alter glycogen levels and nutrients absorption. The ...
Göringer H Ulrich - - 2012
Aptamers are short, synthetic nucleic acid molecules. They are generated by a Darwinian-type in vitro evolution method known as 'systematic evolution of ligands by exponential enrichment' (SELEX). SELEX represents an experimental platform to identify rare ligands with predetermined functionality from combinatorial nucleic acid libraries. Since its discovery about 20 years ...
Kodama Koichi - - 2012
A supramolecular chiral host consisting of N-(2-naphthoyl)-l-aspartic acid (L-1) and meso-1,2-diphenylethylenediamine (2) is effective in enantioseparation of 1-arylethanols (up to 96% ee with 100% inclusion ratio). Here we report three different methods to prepare the inclusion crystals and discuss the chiral recognition mechanism on the basis of X-ray crystallography results.
LE Thanh Hai - - 2012
The chemistry and electrochemistry of TCNQ (7,7,8,8-tetracyanoquinodimethane), TCNQ•-, TCNQ2- and H2TCNQ in acetonitrile (0.1 M Bu4NPF6) solution containing trifluoroacetic acid (TFA) has been studied by transient, and steady-state voltammetric methods with the interrelationship between the redox and the acid-base chemistry being supported by simulations of the cyclic voltammograms. In the ...
Begg Denovan P - - 2012
During heat waves many elderly individuals die as a consequence of dehydration. This is partially due to deficits in mechanisms controlling thirst. Reduced thirst following dipsogenic stimuli is well documented in aged humans and rodents. Low in vivo long-chain omega-3 fatty acid levels, as can occur in aging, have been ...
Sull Jae Woong - - 2012
Elevated uric acid levels are associated with a variety of adverse health risks. Genome-wide association studies have identified several candidate genes associated with serum uric acid levels, including SLC2A9. We carried out a replication study of SLC2A9 variants in two Korean cohorts. A total of 961 participants in Seoul City ...
Yamamoto Toshiharu - - 2012
Estimation of chronological age is essential in forensic and archeological science. The racemization method is one of the best methods to meet the demands of these scientific fields, providing both accuracy of the estimated age and simplicity of technique. In general, living organs are composed of L: -form amino acids. ...
Gilk Stacey D - - 2012
Lipids are essential components of both eukaryotic and prokaryotic cells, serving diverse functions including energy metabolism and membrane structure. Intracellular vacuolar pathogens such as Coxiella burnetii require lipids for both normal bacterial functions as well as formation of the acidic, phagolysosomal-like parasitophorous vacuole (PV) surrounding the bacteria. As an intracellular ...
Miranda Mariana R - - 2012
Trypanosomatids' amino acid permeases are key proteins in parasite metabolism since they participate in the adaptation of parasites to different environments. Here, we report that TcAAP3, a member of a Trypanosoma cruzi multigene family of permeases, is a bona fide arginine transporter. Most higher eukaryotic cells incorporate cationic amino acids ...
Zhang Ou - - 2012
Leishmania parasites alternate between extracellular promastigotes in sandflies and intracellular amastigotes in mammals. These protozoans acquire sphingolipids (SLs) through de novo synthesis (to produce inositol phosphorylceramide) and salvage (to obtain sphingomyelin from the host). A single ISCL (Inositol phosphoSphingolipid phospholipase C-Like) enzyme is responsible for the degradation of both inositol ...
Levitan Emily B - - 2011
α-Linolenic acid (18 : 3n-3) intake and linoleic acid (18 : 2n-6) intake have been associated with lower rates of CHD, though results have not been consistent. The relationship of these fatty acids with incident heart failure (HF) is not well established. We examined the hypothesis that women with higher intakes of 18 : 3n-3 and ...
Snigdha S - - 2012
Despite several recent studies suggesting that dysregulation of brain lipid metabolism might contribute to the mechanisms of aging and Alzheimer's disease (AD), lipid metabolism has not been evaluated extensively in the aging brain. Here, we use a lipidomic approach to demonstrate that antioxidants plus mitochondrial cofactors treatment, either alone or ...
van der Putten Gert-Jan - - 2013
A growing number of older people have teeth, which are vulnerable to oral diseases. To maintain good oral health, an adequate amount of saliva should be secreted and the saliva should possess adequate buffer capacity. The study aim was to investigate the associations of saliva secretion rate and acidity with ...
Tian Yuan - - 2011
Symbiotic gut microbiota is essential for mammalian physiology and analyzing the metabolite compositions of gastrointestinal contents is vital for understanding the microbiome-host interactions. To understand the developmental dependence of the topographical metabolic signatures for the rat gastrointestinal contents, we systematically characterized the metabolite compositional variations of the contents in rat ...
Sonesson Mikael - - 2011
Sonesson M, Ericson D, Kinnby B, Wickström C. Glycoprotein 340 and sialic acid in minor-gland and whole saliva of children, adolescents, and adults. Eur J Oral Sci 2011; 119: 435-440. © 2011 Eur J Oral Sci Glycoprotein 340 (gp-340) is a bacterial-binding glycoprotein found in major-gland and minor-gland saliva. Sialic ...
Lian Huan - - 2011
This study aimed to assess the knowledge, attitude, and practice of folic acid intake for prevention of birth defects in Chinese women of child-bearing age. In this prospective cross-sectional study, a total of 1,338 women aged 20-45 years were randomly selected for interview. Data on folic acid knowledge and information ...
Taniguchi Mutsuko - - 2011
A stable ascorbic acid derivative, 2-O-α-glucopyranosyl-l-ascorbic acid (AA-2G), was evaluated and compared with ascorbic acid for its protective effect against cellular damage and senescence induced by hydrogen peroxide (H(2)O(2)). Pretreatment with AA-2G for 72h promoted the proliferation of normal human dermal fibroblasts (NHDF) and protected against cell damage induced by ...
Humada M J - - 2011
Thirty-three young bulls from Tudanca local breed were used to investigate the effect of two production systems (semi-extensive vs. intensive) and two slaughter ages (12 vs. 14months) on meat fatty acid (FA) composition. Longissimus thoracis from semi-extensive animals had a lower percentage of intramuscular fat (p≤0.001), saturated FAs (p≤0.05), trans-18:1 ...
Tang Chun-Xia - - 2011
An electrochemiluminescent biosensor was designed for the detection of Ag(+) ions and cysteine as well as their interaction study. To this end, a functional nucleic acid was designed for target recognition and probe intercalation.
Moini Mehdi - - 2011
A new capillary electrophoresis mass spectrometry (CE-MS) technique is introduced for age estimation of silk textiles based on amino acid racemization rates. With an l to d conversion half-life of ∼2500 years for silk (B. mori) aspartic acid, the technique is capable of dating silk textiles ranging in age from ...
Lee Junghoon - - 2012
Changes in phospholipid composition and consequent loss of membrane integrity are correlated with loss of seed viability. Furthermore, phospholipid compositional changes affect the composition of the triacylglycerols (TAG), i.e. the storage lipids. Phospholipase D (PLD) catalyses the hydrolysis of phospholipids to phosphatidic acid, and PLDα is an abundant PLD isoform. ...
Lai Wing-Fu - - 2011
Lifespan prolongation is a common desire of the human race. With advances in biotechnology, the mechanism of aging has been gradually unraveled, laying the theoretical basis of nucleic acid therapy for lifespan prolongation. Regretfully, clinically applicable interventions do not exist without the efforts of converting theory into action, and it ...
Bazan Nicolas G - - 2011
Essential polyunsaturated fatty acids (PUFAs) are critical nutritional lipids that must be obtained from the diet to sustain homeostasis. Omega-3 and -6 PUFAs are key components of biomembranes and play important roles in cell integrity, development, maintenance, and function. The essential omega-3 fatty acid family member docosahexaenoic acid (DHA) is ...
Li Shifeng - - 2011
The oxidation reaction of luminol with AgNO(3) can produce chemiluminescence (CL) in the presence of silver nanoparticles (NPs) in alkaline solution. Based on the studies of UV-vis absorption spectra, photoluminescence (PL) spectra and CL spectra, a CL enhancement mechanism is proposed. The CL emission spectrum of the luminol-AgNO(3) -Ag NPs ...
Kwan Elizabeth X EX Clinical Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of - - 2011
Aging and longevity are considered to be highly complex genetic traits. In order to gain insight into aging as a polygenic trait, we employed an outbred Saccharomyces cerevisiae model, generated by crossing a vineyard strain RM11 and a laboratory strain S288c, to identify quantitative trait loci that control chronological lifespan. ...
Park Sun-Hye - - 2011
We here present a new anti-tumor mechanism of all-trans retinoic acid (ATRA). ATRA induced several biomarkers of cellular senescence including irreversible G(1) arrest, morphological changes, senescence-associated β-galactosidase, and heterochromatin foci in HepG2 cells. ATRA also upregulated levels of p16, p21, and p27 which lead to activation of Rb and subsequent ...
Ren Wen - - 2011
Herein graphene oxide/Ag nanoparticles hybrids (GO/AgNPs) were fabricated according to a self-assembly procedure. Using the obtained GO/AgNPs as SERS substrates, an ultra-sensitive and label-free detection of folic acid in water and serum was demonstrated based on the inherent SERS spectra of folic acid. The modified graphene oxide exhibited strong enrichment ...
Fujii Noriko - - 2011
Homochirality is essential for life. l-Amino acids are exclusively used as substrates for the polymerization and formation of peptides and proteins in living systems. However, d-amino acids, which are enantiomers of l-amino acids, were recently detected in various living organisms in the form of free d-amino acids and d-amino acid ...
Arany Szilvia - - 2011
This study describes an innovative application of a well-established method of age determination. The conventional method of aspartic acid racemization (AAR) is based on estimation of the d-l-aspartic acid ratio in slow turnover tissues, such as tooth tissue, to reflect the age of an individual. This method has been recently ...
Purushothaman Sreeja - - 2011
Prevention of left ventricular hypertrophy remains a challenge in the prevention of hypertension induced adverse cardiac remodeling. Cardiac hypertrophy is associated with a shift in energy metabolism from predominantly fatty acid to glucose with a corresponding reduction in the expression of fatty acid oxidation (FAO) enzyme genes. Though initially adaptive, ...
Stern Seth J - - 2011
: Although maternal folate deficiency during the periconceptional period represents a major risk factor for neural tube defects, obesity has been recognized as an additional risk factor. Studies have identified an increased risk for neural tube defect-affected births among obese mothers even after adjusting for folic acid supplementation. However, although ...
Wang An Jiang AJ Departments of Gastroenterology Otorhinolaryngology, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong Province, - - 2011
To define the normative data of gastroesophageal reflux (GER) and laryngopharyngeal reflux (LPR) in healthy Chinese volunteers. Healthy volunteers without gastrointestinal and throat disease and symptoms were enrolled and underwent 24-hour impedance-pH monitoring. A total of 37 healthy volunteers completed all the tests (female 54.1%; age 38.0±15.2 years). Of 1862 ...
Cotlarciuc Ioana - - 2011
Background/Aims: Elevated levels of total homocysteine (tHcy) are associated with an increased risk of many common diseases. Supplementation with folic acid has been shown to significantly reduce tHcy levels. We used the classical twin model to partition the variability in changes in plasma tHcy levels through folic acid supplementation into ...
Chew Emily Y - - 2011
Neovascularization is a pathogenic event common to retinopathy of prematurity and age-related macular degeneration. A recent study uncovers a mechanism that mediates a nutritional effect on this process in mice.
Andreeva Valentina A - - 2011
BACKGROUND: Rapid aging of the population worldwide necessitates a heightened concern about preventing cognitive decline. OBJECTIVE: We investigated the effects of B vitamins and omega-3 (n-3) fatty acid supplementation on cognition in a high-risk population. DESIGN: This was an ancillary study of the SU.FOL.OM3 (SUpplementation with FOLate, vitamins B-6 and ...
Houghton Lisa A - - 2011
Understanding the full effect of chronic low-dose folic acid is important in interpreting the effect of the mandatory folic acid fortification program in North America. We aimed to describe the rate of attainment and steady state (plateau) of red blood cell (RBC) folate in response to long-term intake of 140 ...
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