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Du Hongliang H Department of Pharmaceutics, College of Pharmacy, Shandong University, 44 Wenhua Xilu, Jinan 250012, - - 2014
O-carboxymethyl chitosan (OCMC) was firstly decorated with cholic acid (CA) to acquire an amphiphilic polymer under alkaline condition. Then glycyrrhetinic acid (GA) was conjugated to the polymer via a succinate linker and finally treated with NaCO3 solution to obtain new conjugates for potential liver targeted delivery. These conjugates formed uniform ...
Wu Size S Department of Medical Imaging, Affiliated Hospital of Hainan Medical College, Haikou, China. - - 2014
The purpose of this study was to investigate whether focal fatty sparing can arise in preexisting nonalcoholic diffuse homogeneous fatty liver and its clinical implications. This prospective study consisted of 2 parts. In the first part, 8598 people (5202 men and 3396 women; mean age ± SD, 43.4 ± 28.3 ...
Eey Stanley T-C ST Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543 - - 2014
(-)-Platensimycin is a potent inhibitor of fatty acid synthase that holds promise in the treatment of metabolic disorders (e.g., diabetes and "fatty liver") and pathogenic infections (e.g., those caused by drug-resistant bacteria). Herein, we describe its total synthesis through a four-step preparation of the aromatic amine fragment and an improved ...
Schweiker Stephanie S SS Eskitis Institute for Drug Discovery, Nathan Campus, Griffith University, Brisbane, QLD 4111, Australia; Faculty of Health Sciences and Medicine, Bond University, Gold Coast, QLD 4229, - - 2014
A series of morpholine substituted amino acids (phenylalanine, leucine, lysine and glutamic acid) was synthesized. A fragment-based screening approach was then used to evaluate a series of small heterocycles, including morpholine, oxazoline, dihydro-1,3-oxazine, tetrahydro-1,3-oxazepine, thiazoline, tetrahydro-1,3-pyrimidine, tetrahydro-1,3-diazepine and hexahydro-1H-benzimidazole, as potential inhibitors of Glycogen Phosphorylase a. Thiazoline 7 displayed an ...
Jiao Yu Y Key Laboratory of Applied Marine Biotechnology, Ministry of Education, Ningbo University, Ningbo 315211, - - 2014
Cathepsin D (CTSD) is a lysosomal acidic endoproteinase that plays an important role in immune response. In this study, we obtained sweetfish (Plecoglossus altivelis) CTSD (PaCTSD) via de-novo transcriptome sequencing of sweetfish macrophages. The full length cDNA sequence of PaCTSD was 1 955 bp encoding a propeptide of 397 amino ...
Beckmann C L CL School of Biological Sciences, Flinders University, Adelaide, South Australia, 5001, - - 2014
The muscle and liver fatty acid composition of young-of-the-year (YOY) Port Jackson sharks Heterodontus portusjacksoni were investigated to determine the effects of a known dietary lipid source v. maternal input as demonstrated by egg yolk fatty acid profiles. Ten Heterodontus portusjacksoni egg yolks were collected in situ and compared with ...
Falk Sandy S Hessian State Laboratory, Glarusstr. 6, 65203 Wiesbaden, Germany. Electronic address: - - 2014
Tissue specific uptake and elimination of perfluoroalkyl acids (PFAAs) were studied in rainbow trout (Oncorhynchus mykiss). Adult trout were exposed to perfluorobutane sulfonic acid (PFBS), perfluorohexane sulfonic acid (PFHxS), perfluorooctane sulfonic acid (PFOS), perfluorooctanoic acid (PFOA) and perfluorononanoic acid (PFNA) via food over a time period of 28d. In the ...
Mamoon Abulkhair A Department of Medicine, University of Mississippi Medical Center, Jackson, MS 39216, - - 2014
Retinoic acid (RA) effects multiple aspects of development, embryogenesis and cell differentiation processes. The liver is a major organ that stores RA suggesting that retinoids play an important role in the function of hepatocytes. In our previous studies, we have demonstrated the involvement of small heterodimer partner (SHP) in RA-induced ...
Wan Yun Y Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350122, P.R. China ; Fujian Key Laboratory of Integrative Medicine on Geriatrics, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350122, P.R. - - 2014
One of the most common causes of chronic liver disease, nonalcoholic fatty liver disease (NAFLD), is strongly associated with obesity and dysregulated insulin action in the liver. However, there are no pharmacological agents currently established for the treatment of NAFLD. A flowering plant in the Asteraceae family, Cirsium japonicum (CJ), ...
Aouadi Myriam M University of - - 2014
Pro-inflammatory pathways in adipose tissue macrophages (ATMs) can impair glucose tolerance in obesity, but ATMs may also be beneficial as repositories for excess lipid that adipocytes are unable to store. To test this hypothesis, we selectively targeted visceral ATMs in obese mice with siRNA against lipoprotein lipase (LPL), leaving macrophages ...
Kharbanda Kusum K KK Research Service, Veterans Affairs Nebraska-Western Iowa Health Care System, Omaha, Nebraska; Departments of Internal Medicine and Biochemistry & Molecular Biology, University of Nebraska Medical Center, Omaha, - - 2014
Li and colleagues (2014) in this issue report that dietary nicotinic acid (NA) supplementation ameliorates ethanol-induced hepatic steatosis, but a deficiency does not worsen injury induced by alcohol alone. The authors further present some mechanistic insights into the protective role of NA supplementation. Results of this and other previous studies ...
Peter Andreas A Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Medicine, Nephrology and Clinical Chemistry, University of Tübingen, Otfried-Müller-Str. 10, 72076, Tübingen, Germany, - - 2014
The common sequence variant I148M of the patatin-like phospholipase domain-containing protein 3 gene (PNPLA3) is associated with increased hepatic triacylglycerol (TAG) content, but not with insulin resistance, in humans. The PNPLA3 (I148M) variant was previously reported to alter the specificity of the encoded enzyme and subsequently affect lipid composition. We ...
Kawaguchi Takumi T Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Kurume 830‑0011, - - 2014
Glucagon‑like peptide‑1 (GLP‑1) is involved in the development of non‑alcoholic steatohepatitis (NASH), which is characterized by fatty acid imbalance. The aim of this study was to investigate the effects of the GLP‑1 receptor (GLP‑1R) agonist, exendin‑4 (Ex‑4), on hepatic fatty acid metabolism and its key enzyme, Δ‑5‑desaturase, in a murine model of NASH. NASH ...
Ginanni Corradini Stefano S From the Department of Clinical Medicine, Gastroenterology Division (SGC, FM, LP, AM, and EP), the Departments of General Surgery "Paride Stefanini" (GM and MR), and the Department of Molecular Medicine (AC and PB), "Sapienza" University of Rome, Rome, Italy; the Department of Medical-Surgical Sciences and Biotechnology, Vascular Biology and Mass Spectrometry Laboratory, "Sapienza" University of Rome, Latina, Italy (CZ, GP, AGB, and LI); the School of Health Sciences, Department of Nutrition, Ariel University, Ariel, Israel (MB); and the Department of Medical Sciences, Università of Foggia, Foggia, Italy - - 2014
Knowledge regarding the plasma fatty acid (FA) pattern in patients with liver cirrhosis is fragmentary.OBJECTIVE: We evaluated plasma FA lipidome and its association with the prognosis of cirrhosis and severity of liver graft damage after transplantation.DESIGN: In this observational study, plasma FA lipidome was investigated in 51 cirrhotic patients before ...
Aguirre Leixuri L Leixuri Aguirre, Maria Puy Portillo, Nutrition and Obesity Group, Department of Nutrition and Food Science, University of Basque Country (UPV/EHU) and Centro de Investigación Lucio Lascaray, 01006 Vitoria, - - 2014
Non-alcoholic fatty liver disease covers a wide spectrum of liver pathologies which range from simple steatosis to non-alcoholic steatohepatitis. Polyphenols are members of a very large family of plant-derived compounds that can have beneficial effects on human health, and thus their study has become an increasingly important area of human ...
Patanwala Imran I From the Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom (IP, MH, and DEJ); the Institute of Food Research, Norwich Research Park, Norwich, United Kingdom (MJK, MP, JRD, AJAW, and PMF); the Centre for Analytical Bioscience, School of Pharmacy, University of Nottingham, Nottingham, United Kingdom (DAB); and the Department of Radiology, Freeman Hospital, Newcastle upon Tyne, United Kingdom (JR and - - 2014
Current thinking, which is based mainly on rodent studies, is that physiologic doses of folic acid (pterylmonoglutamic acid), such as dietary vitamin folates, are biotransformed in the intestinal mucosa and transferred to the portal vein as the natural circulating plasma folate, 5-methyltetrahydrofolic acid (5-MTHF) before entering the liver and the ...
Hage Hassan Rima R Rima Hage Hassan, Olivier Bourron, Eric Hajduch, INSERM, UMR-S 1138, Centre de Recherche des Cordeliers, F-75006 Paris, - - 2014
In healthy people, balance between glucose production and its utilization is precisely controlled. When circulating glucose reaches a critical threshold level, pancreatic β cells secrete insulin that has two major actions: to lower circulating glucose levels by facilitating its uptake mainly into skeletal muscle while inhibiting its production by the ...
Gonzales Gustavo F - - 2014
Abstract Background: Currently there are no studies on γ-glutamyltransferase (γGT) levels at high altitude or on the relationship between γGT, uric acid and several dysfunctions. The aim of the study was to determine the association between serum γGT and uric acid levels in subjects at high altitude with hemoglobin, glycemia, ...
Numata Jorge - - 2014
We investigate the transfer of a mixture of perfluoroalkyl acids (PFAAs) from contaminated feed into the edible tissues of 24 fattening pigs. Four perfluoroalkyl sulfonic (PFSAs) and three perfluoroalkyl carboxylic acids (PFCAs) were quantifiable in feed, plasma, edible tissues and urine. As percentages of unexcreted PFAA, the substances accumulated in ...
Li Zhi - - 2014
The properties of an ideal photosensitizer are water solubility, low cytotoxicity in the dark, high ability to produce reactive oxygen species (ROS). The characteristics of water-soluble fullerene (C60) amino acid nanoparticles as a photosensitizer were evaluated. C60 modified with l-phenylalanine (C60-phe) or glycine (C60-gly) was very efficient to carry out ...
Wang Jun-Ming JM MOE Key Laboratory for Standardization of Chinese Medicines and Shanghai Key Laboratory of Complex Prescription, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; Center for Drug Safety Evaluation and Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; School of Pharmacy, Henan University of Traditional Chinese Medicine, Zhengzhou 450008, - - 2014
The present study is designed to investigate the protection by ferulic acid against the hepatotoxicity induced by diosbulbin B and its possible mechanism, and further observe whether ferulic acid augments diosbulbin B-induced anti-tumor activity. The results show that ferulic acid decreases diosbulbin B-increased serum alanine transaminase/aspartate transaminase (ALT/AST) levels. Ferulic ...
Vuarin Pauline P UMR 7179 Centre National de la Recherche Scientifique, Muséum National d׳Histoire Naturelle, 1 avenue du Petit Château, 91800 Brunoy, - - 2014
Optimal levels of unsaturated fatty acids have positive impacts on the use of prolonged bouts of hypothermia in mammalian hibernators, which generally have to face low winter ambient temperatures. Unsaturated fatty acids can maintain the fluidity of fat and membrane phospholipids at low body temperatures. However, less attention has been ...
Wang Song S State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, - - 2014
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease. Its incidence is rising worldwide. However, no specific therapy has been shown to be effective in its treatment. In the present study, the in vitro NAFLD model was established in human SMMC-7721 cells by using oleic acid (OA). ...
Liu Yong Y Department of Radiation Oncology,Lineberger Comprehensive Cancer Center, andLaboratory of Biological Cancer Therapy, Xuzhou Medical College, Xuzhou 221002, - - 2014
The tumor suppressor p53 has recently been shown to regulate energy metabolism through multiple mechanisms. However, the in vivo signaling pathways related to p53-mediated metabolic regulation remain largely uncharacterized. By using mice bearing a single amino acid substitution at cysteine residue 305 of mouse double minute 2 (Mdm2(C305F)), which renders ...
Banerjee Mayukh M University of - - 2014
Hundreds of millions of people world-wide are exposed to unacceptable levels of arsenic in drinking water. This is a public health crisis because arsenic is a Group I (proven) human carcinogen. Human cells methylate arsenic to monomethylarsonous acid (MMA(III)), monomethylarsonic acid (MMA(V)), dimethylarsinous acid (DMA(III)), and dimethylarsinic acid (DMA(V)). Although ...
Kobayashi Misato M a Department of Applied Molecular Biosciences , Graduate School of Bioagricultural Sciences, Nagoya University , Nagoya , - - 2014
The mechanisms underlying the decrease in hepatic cytochrome P-450 (CYP) content in ascorbic acid deficiency was investigated in scurvy-prone ODS rats. First, male ODS rats were fed a diet containing sufficient ascorbic acid (control) or a diet without ascorbic acid (deficient) for 18 days, with or without the intraperitoneal injection of ...
Cotter David G DG Washington - - 2014
Peroxisome proliferator activated receptor alpha (PPARα) is a master transcriptional regulator of hepatic metabolism, and mediates the adaptive response to fasting. Here we demonstrate the roles for PPARα in hepatic metabolic adaptations to birth. Like fasting, nutrient supply is abruptly altered at birth when a transplacental source of carbohydrates is ...
Park Ki-Hoon KH School of Biotechnology, Yeungnam University, Gyeongsan, Republic of Korea; Research Institute of Protein Sensor, Yeungnam University, Gyeongsan, Republic of Korea; BK21plus Program Serum Biomedical Research and Education Team, Yeungnam University, Gyeongsan, Republic of - - 2014
It is well known that trans-fatty acids have proatherogenic properties while HDL has antiatherogenic activities in plasma. However, there has been no report on the effects of trans-fat on the functional and structural properties of HDL. To compare physiological properties, we synthesized reconstituted HDL (rHDL) containing stearic acid (18:0), oleic ...
Leamy Alexandra K AK Vanderbilt University, United - - 2014
High levels of saturated fatty acids (SFAs) are acutely toxic to a variety of cell types, including hepatocytes, and have been associated with diseases such as type 2 diabetes and non-alcoholic fatty liver disease. SFA accumulation has been previously shown to degrade endoplasmic reticulum (ER) function leading to other manifestations ...
Jacometo Carolina B CB Department of Animal Science, Agronomy College, Federal University of Pelotas, Campus Universitário, Pelotas, RS, CEP 96010-900, Brazil, - - 2014
The essential fatty acids, omega-3 and omega-6, consumed during pregnancy can benefit maternal and offspring health. For instance, they could activate a network of genes related to the nuclear receptor peroxisome proliferator-activated receptor α (Ppara) and sterol regulatory element binding transcription factor 1 (Srebf1), which play a role in fatty ...
Dahlhoff Christoph C Biochemistry Unit, Research Center for Nutrition and Food Sciences (ZIEL), Technische Universität München, 85350 Freising-Weihenstephan, Germany ; PhD Group - Epigenetics, Imprinting and Nutrition, Research Center for Nutrition and Food Sciences (ZIEL), Technische Universität München, 85350 Freising-Weihenstephan, - - 2014
Non-alcoholic fatty liver disease (NAFLD) results from increased hepatic lipid accumulation and steatosis, and is closely linked to liver one-carbon (C1) metabolism. We assessed in C57BL6/N mice whether NAFLD induced by a high-fat (HF) diet over 8 weeks can be reversed by additional 4 weeks of a dietary methyl-donor supplementation ...
Eisinger Kristina K Department of Internal Medicine I, Regensburg University Hospital, Regensburg, - - 2014
Fatty liver is closely associated with obesity and sensitizes the liver to further insults. Intention of the current study is 1) to identify lipid species changed in rodent fatty liver, 2) to analyze for possible associations of these lipids with triglycerides, cholesterol or CXCL8 which is elevated in the steatotic ...
Quintero Pablo P Departamento de Gastroenterología, Escuela de Medicina, Pontificia Universidad Católica de Chile, Marcoleta 367, Santiago, - - 2014
Bile acids or its derivatives may influence non-alcoholic fatty liver disease development through multiple mechanisms. Intestinal L-cells secrete glucagon-like peptide-1 (GLP-1) and can be activated by bile acids (BA) influencing insulin resistance and hepatic steatosis development and progression. The aim of the present study was to assess the effects of ...
Tripathy Sasmita S Oregon State University, United - - 2014
Nonalcoholic fatty liver disease (NAFLD) is a major public health concern in the obese and type 2 diabetic populations. The high fat lard diet (HFD) induces obesity and fatty liver in C57BL/6J mice and suppresses expression of the PPAR-target gene, fatty acid elongase-5 (Elovl5). Elovl5 plays a key role in ...
Zhou Huiping H Department of Microbiology and Immunology, Virginia Commonwealth University, Medical College of Virginia Campus, Richmond, Virginia 23298; McGuire VA Medical Center, Richmond, Virginia 23249, United States. Electronic address: - - 2014
Bile salts play crucial roles in allowing the gastrointestinal system to digest, transport and metabolize nutrients. They function as nutrient signaling hormones by activating specific nuclear receptors (FXR, PXR, Vitamin D) and G-protein coupled receptors [TGR5, sphingosine-1 phosphate receptor 2 (S1PR2), muscarinic receptors]. Bile acids and insulin appear to collaborate ...
Safadi Rifaat R Liver and Gastroenterology Units, Division of Medicine, Hadassah University Medical Center, Jerusalem, Israel; Holy Family Hospital, Nazareth, Israel. Electronic address: - - 2014
We investigated the effects of the fatty acid-bile acid conjugate 3β-arachidyl-amido, 7α-12α-dihydroxy, 5β-cholan-24-oic acid (aramchol) in a phase 2 trial of patients with non-alcoholic fatty liver disease (NAFLD). We performed a randomized, double-blind, placebo-controlled trial of 60 patients with biopsy-confirmed NAFLD (6 with non-alcoholic steatohepatitis, NASH) at 10 centers in ...
Fu Ying Y Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, District of Columbia - - 2014
Previous studies showed that the 7-(1',2'-dihydroxyheptyl) substituted etheno DNA adducts are products from reactions with epoxide of (E)-4-hydroxy-2-nonenal (HNE), an oxidation product of ω-6 polyunsaturated fatty acids (PUFAs). In this work, we report the detection of 7-(1',2'-dihydroxyheptyl)-1,N(6)-ethenodeoxyadenosine (DHHedA) in rodent and human tissues by two independent methods: a (32)P-postlabeling/HPLC method ...
Betancor Mónica B MB Institute of Aquaculture, School of Natural Sciences, University of Stirling, Stirling FK9 4LA Scotland. Electronic address: - - 2014
To investigate interactions of dietary LC-PUFA, a dose-response study with a range of docosahexaenoic acid (DHA; 22:6n-3) levels (1gkg(-1), 5gkg(-1), 10gkg(-1), 15gkg(-1) and 20gkg(-1)) was performed with post-smolts (111±2.6g; mean±S.D.) over a nine-week feeding period. Additional diets included 10gkg(-1) DHA in combination with 10gkg(-1) of either eicosapentaenoic acid (EPA; 20:5n-3) ...
Liao Shang-Gao SG Provincial Key Laboratory of Pharmaceutics in Guizhou Province, School of Pharmacy, Guiyang Medical College, 9 Beijing Road, Guiyang, Guizhou, PR - - 2014
Tablets of oleanolic acid (OA) have been approved by SFDA in China as an adjuvant therapy for acute and chronic hepatitis. Co-occurring substances present in the tablets of OA and their hepatocytotoxicity have not yet been reported. In the current investigation, the crude OA drug was separated by repeated column ...
Ide Takashi T Laboratory of Nutritional Function, National Food Research Institute, 2-1-12 Kannondai, Tsukuba 305-8642, - - 2014
In the present study, the mRNA levels of hepatic proteins involved in the drug metabolism of rats fed α-lipoic acid were evaluated by DNA microarray and real-time PCR analyses. Experimental diets containing 0, 0·1, 0·25 and 0·5 % (w/w) α-lipoic acid were fed to four groups of rats consisting of seven ...
Jacome-Sosa M Miriam MM Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri, - - 2014
Different sources of fatty acids (FA) used for VLDL-triglyceride synthesis include dietary FA that clear to the liver via chylomicron uptake, FA synthesized de novo in the liver from carbohydrates, nonesterified fatty acids derived from adipose tissue, nonesterified fatty acids derived from the spillover of chylomicron-triglyceride in the fasted and ...
Lands Bill B ASN, AAAS, SFRBM, College Park, MD, USA. Electronic address: - - 2014
Current public advice from the Food and Nutrition Board (FNB) about essential fatty acids (EFA) has limited quantitative details about three processes: 1.- similar dynamics for n-3 linolenic and n-6 linoleic polyunsaturated fatty acids (PUFA) in maintaining 20- and 22-carbon n-3 and n-6 highly unsaturated fatty acids (HUFA) in tissues; ...
Li Heng-Hong HH Department of Biochemistry and Molecular & Cellular Biology, Georgetown University, Washington, District of - - 2014
Chronic alcohol intake affects liver function and causes hepatic pathological changes. It has been shown that peroxisome proliferator-activated receptor α (PPARα)-null mice developed more pronounced hepatic changes than wild-type (WT) mice after chronic exposure to a diet containing 4% alcohol. The remarkable similarity between the histopathology of alcoholic liver disease ...
Heebøll Sara S Sara Heebøll, Karen Louise Thomsen, Hendrik Vilstrup, Henning Grønbæk, Department of Hepatology and Gastroenterology, Aarhus University Hospital, 8000 Aarhus C, - - 2014
The prevalence of obesity and related conditions like non-alcoholic fatty liver disease (NAFLD) is increasing worldwide and therapeutic options are limited. Alternative treatment options are therefore intensively sought after. An interesting candidate is the natural polyphenol resveratrol (RSV) that activates adenosinmonophosphate-activated protein kinase (AMPK) and silent information regulation-2 homolog 1 ...
Zhang Hong-Li HL Zhejiang Provincial Key Laboratory of Biometrology and Inspection & Quarantine, Department of Pharmacy, College of Life Sciences, China Jiliang - - 2014
Hepatitis B is the most common serious liver infection in the world. To date, there is still no complete cure for chronic hepatitis B. Natural caffeic acid analogues possess prominent antiviral activity, especially anti-HBV and anti-HIV effects. Cichoric acid is a caffeic acid derivative from Cichorium intybus. In the study, ...
Yu Zhen Z Department of Biochemistry and Biophysics, Linus Pauling Institute, Oregon State University, 307 Linus Pauling Science Center, Corvallis, OR 97331. - - 2014
Dietary restriction (DR) is the gold standard intervention used to delay aging, and much recent research has focused on the identification of possible DR mimetics. Energy sensing pathways, including insulin/IGF1 signaling, sirtuins, and mammalian Target of Rapamycin (mTOR), have been proposed as pathways involved in the antiaging actions of DR, ...
Laggai Stephan S Saarland University, Pharmaceutical Biology, - - 2014
Liver-specific overexpression of the insulin-like growth factor 2 (IGF2) mRNA binding protein p62/IGF2BP2-2 induces a fatty liver, which highly expresses IGF2. Since IGF2 expression is elevated in patients with steatohepatitis, the aim of our study was to elucidate the role and interconnection of p62 and IGF2 in lipid metabolism. Expression ...
Bisogno Tiziana T Endocannabinoid Research Group, Institute of Biomolecular Chemistry, National Research Council, 80078, Pozzuoli, Italy; Center of Integrated Research, Campus Bio-Medico University of Rome, 00128, Rome, - - 2014
Diet plays a central role in maintaining health throughout life and a controlled food intake is associated to a reduced risk of certain diseases. A proper diet should include vitamins, minerals, carbohydrates, proteins, and fats that have to be optimally balanced in order to exert their physiological functions. The endogenous ...
Rood Jennifer C JC Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana, USA. Electronic address: - - 2014
Botanical compounds and extracts are widely used as nutritional supplements for the promotion of health or the prevention of disease. An extract of Artemisia dracunculus (PMI 5011) has been shown to improve insulin action, yet the precise mechanism is not known. The aim of this study is to demonstrate that ...
Kawano Yuki Y Department of Medicine, Division of Gastroenterology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, - - 2014
Thioesterase superfamily member 2 (Them2) is a mitochondria-associated long chain fatty acyl-CoA thioesterase that is highly expressed in liver and oxidative tissues. Them2 activity in vitro is increased when it interacts with phosphatidylcholine transfer protein (PC-TP), a cytosolic lipid binding protein. Them2(-/-) and Pctp(-/-) mice exhibit enhanced hepatic insulin sensitivity ...
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