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Zhang Tianshun T Department of Agrobioscience, Graduate School of Agricultural Science, Kobe University, Kobe 657-8501, Japan. - - 2014
Excessive lipid accumulation in the liver has been proposed to cause hyperlipidemia, diabetes and fatty liver disease. 4-Hydroxyderricin (4HD), xanthoangelol (XAG), cardamonin (CAR) and flavokawain B (FKB) are chalcones that have exhibited various biological effects against obesity, inflammation, and diabetes; however, little is known about the inhibitory effects of these ...
Della Corte Claudia C Hepato-Metabolic Disease Unit and Liver Research Unit, "Bambino Gesù" Children's Hospital, IRCCS, P.le S. Onofrio 4, 00165 Rome, - - 2014
Central obesity represents the major factor responsible for NAFLD, but several immunological and endocrinological mechanisms are involved in fatty infiltration in the liver, inflammation and fibrosis. Gut microbiota and genetic factors were recently indicated as major players in liver injury. Loss of weight and physical activity represent till now the ...
Saito Hiroaki H National Research Institute of Fisheries Science, Fisheries Research - - 2014
The lipid and fatty acid compositions of the muscle and liver of five Epinephelinae fishes (Epinephelus fasciatus, Epinephelus retouti, Cephalopholis aurantia, Cephalopholis miniatus, and Variola louti) in the coral reef were investigated. The major polyunsaturated fatty acid (PUFA) in the Epinephelinae fish triacylglycerols was 22:6n-3 (docosahexaenoic acid; DHA), which was ...
Durairaj Varalakshmi V Department of Biochemistry and Molecular Biology, School of Life Sciences, Pondicherry University, Puducherry, 605014, - - 2014
Alcoholism is a broad term used for problems related to alcohol, medically considered as disease, specifically an addictive illness, abuse, and dependence. It is the major cause of liver disease in western countries. Alcoholic liver disease encompasses the hepatic alterations leading to fatty liver, hepatitis, and fibrosis or cirrhosis. Fried ...
Tang Maoxue M Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing, 100193, People's Republic of - - 2014
Genetically modified animals rich in omega-3 unsaturated fatty acid offer a new strategy to improve the human health, but at the same time present a challenge in terms of food safety assessment. In this study, we evaluated the function and safety of sFat-1 transgenic pork rich in omega-3 fatty acids ...
Arakawa Yusuke Y Assistant Professor, Institute of Health Biosciences, Department of Surgery, The University of Tokushima Graduate School 3-18-15 Kuramoto, Tokushima 770-8503, Japan. - - 2014
Oxaliplatin-based chemotherapy can cause hepatic sinusoidal injury such as sinusoidal obstructive syndrome (SOS). Spleen size is correlated with sinusoidal damage, and serum hyaluronic acid is also a marker of SOS. The aim of the present study was to clarify the impact of the current chemotherapeutic regimen plus bevacizumab against oxaliplatin-associated ...
Kan Shidong S State Key Lab of New Drug and Pharmaceutical Processes, Shanghai Inst. of Pharmaceutical Industry, Nr. 1320, West Beijing Rd, Shanghai, 200040, - - 2014
Salvianolic acid A (Sal A) was considered to be the compound with highest activity in Salvia miltiorrhiza (danshen). Due to its low content in raw materials, many studies reported its preparation from salvianolic acid B (Sal B). However, the process of this transformation is still unknown. Our objective was to ...
Basili Stefania S First Medical Clinic (Department of Internal Medicine and Medical Specialties), Sapienza-University of Rome, - - 2014
NADPH-oxidase-2 up-regulation has been suggested in liver damage perpetuation via an oxidative stress-mediated mechanism. n-6/n-3 polyunsaturated fatty acids ratio derangement has been reported in liver disease. To explore polyunsaturated fatty acids balance and its interplay with platelet oxidative stress in liver cirrhosis. A cross-sectional study in 51 cirrhotic patients and ...
Huang Qiaoyan Q Institute of Evolution & Marine Biodiversity and Department of Marine Biology, Ocean University of - - 2014
Gpr84 was recently identified as a receptor for medium-chain fatty acids, but its functions remain to be clarified. We reported the identification of a zebrafish Gpr84 homologue (zGpr84), which has a higher gene expression in the tissues of intestine, heart and liver. During embryogenesis, zGpr84 is maternally expressed and a ...
Zhang Qinghao Q Marine Biology Institute & Guangdong Provincial Key Laboratory of Marine Biotechnology, Shantou University, Shantou, Guangdong, - - 2014
Biosynthesis in vertebrates of long-chain polyunsaturated fatty acids (LC-PUFA) such as arachidonic (ARA; 20:4n-6), eicosapentaenoic (EPA; 20:5n-3) and docosahexaenoic (DHA; 22:6n-3) acids requires the catalysis by fatty acyl desaturases (Fad). A vertebrate Fad with Δ4 activity, catalyzing the direct conversion of 22:5n-3 to DHA was discovered in the marine teleost ...
Ding X X Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, PR - - 2014
Abnormal fatty acid oxidation (FAO) and lipid metabolism have been found related to preeclampsia (PE). Antiphospholipid syndrome (APS) as a clinical risk factor for PE has also been reported with abnormal lipid metabolism. However, the role of FAO in PE accompanied with APS is unknown. We aimed to investigate long-chain ...
Dai Dongling D Clinical and Molecular Genetics Unit, UCL Institute of Child Health, London, WC1N 1EH, - - 2014
A child of consanguineous parents of Pakistani origin developed jaundice at 5 weeks and then, at 3 months, irritability, a prolonged prothrombin time, a low albumin, and episodes of hypoglycaemia. Investigation showed an elevated alanine aminotransferase with a normal γ-glutamyl-transpeptidase. Analysis of urine by electrospray ionisation tandem mass spectrometry (ESI-MS/MS) showed that ...
Huang Huan H Department of Physiology and Pharmacology, Texas A&M University, TVMC College Station, TX, - - 2014
The human liver fatty acid binding protein (L-FABP) T94A variant, the most common in the FABP family, has been associated with elevated liver triglyceride (TG) levels. How this amino acid substitution elicits these effects is not known. This issue was addressed with human recombinant wild-type (WT, T94T) and T94A variant ...
da Costa Ana Sofia - - 2014
In ruminants, unsaturated dietary fatty acids are biohydrogenated in the rumen and are further metabolised in various tissues, including liver, which has an important role in lipid and lipoprotein metabolism. Therefore, manipulation of muscle fatty acid composition should take into account liver metabolism. In the present study, the influence of ...
Cho Hyun Kook HK Department of Molecular Biology, Pusan National University, Busan, 609-735, - - 2014
The protein level of human hepatitis B virus (HBV) in infection is variable dependent on patient context. We previously reported that HBV X protein (HBx) induces hepatic lipid accumulation and inflammation. Here, we show that abnormal levels of hepatic fatty acids increase HBx protein stability during HBV expression, resulting in ...
Tu Qian-Qian QQ International Co-operation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Institute, Second Military Medical University, Shanghai 200433, - - 2014
Aim:Free fatty acid-induced lipotoxicity plays a crucial role in the progression of nonalcoholic fatty liver disease (NAFLD). In the present study we investigated the effects of a high-fat diet and free fatty acids on the autophagic process in hepatocytes in vivo and in vitro and the underlying mechanisms.Methods:LC3-II expression, a ...
Sahini Nishika N Centre for Pharmacology and Toxicology, Hannover Medical School, 30625 Hannover, - - 2014
Triacyglycerols are a major energy reserve of the body and are normally stored in adipose tissue as lipid droplets (LDs). The liver, however, stores energy as glycogen and digested triglycerides in the form of fatty acids. In stressed condition such as obesity, imbalanced nutrition and drug induced liver injury hepatocytes ...
Li Xinwei X Key Laboratory of Zoonosis, Ministry of Education, College of Veterinary Medicine, Jilin University, 5333 Xi'an Road, Changchun, Jilin, 130062, - - 2014
The natural incidence of fatty liver in ruminants is significantly higher than in monogastric animals. Fatty liver is associated with sterol regulatory element-binding protein 1c (SREBP-1c). The aim of this study was to investigate the regulatory network effects of SREBP-1c on the lipid metabolic genes involved in fatty acid uptake, ...
Yan Hu H 1Department of Pharmacology, Dalian Medical University, Dalian, China. 2Department of Pharmacy, Second Affiliated Hospital of Dalian Medical University, Dalian, China. 3Department of General Surgery, Second Affiliated Hospital of Dalian Medical University, Dalian, - - 2014
Ischemia/reperfusion is a leading cause of liver damage after surgical intervention, trauma, and transplantation. It has been reported that the nicotinamide adenine dinucleotide-dependent deacetylase sirtuin 1 attenuates myocardial, cerebral, and renal ischemia/reperfusion damage. This study aimed to investigate the involvement of sirtuin 1-mediated p66shc inhibition in liver ischemia/reperfusion and explore ...
Kratzer James T JT School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA - - 2014
Uricase is an enzyme involved in purine catabolism and is found in all three domains of life. Curiously, uricase is not functional in some organisms despite its role in converting highly insoluble uric acid into 5-hydroxyisourate. Of particular interest is the observation that apes, including humans, cannot oxidize uric acid, ...
Scorletti E E Human Development and Health Academic Unit, Faculty of Medicine, University of Southampton, Southampton, UK. Electronic address: - - 2014
Non-alcoholic fatty liver disease (NAFLD) represents a range of liver conditions from simple fatty liver to progressive end stage liver disease requiring liver transplantation. NAFLD is common in the population and in certain sub groups (e.g. type 2 diabetes) up to 70% of patients may be affected. NAFLD is not ...
Rogue Alexandra A Inserm UMR 991, F-35043 Rennes cedex, France; Université de Rennes 1, Faculté des Sciences Pharmaceutiques et Biologiques, 35043 Rennes cedex, France; Biologie Servier, Gidy, - - 2014
Although non-alcoholic fatty liver disease (NAFLD) is currently the most common form of chronic liver disease there is no pharmacological agent approved for its treatment. Since peroxisome proliferator-activated receptors (PPARs) are closely associated with hepatic lipid metabolism, they seem to play important roles in NAFLD. However, the effects of PPAR ...
Tang Chang-Chieh CC Institute of Biochemistry and Biotechnology, College of Medicine, Chung Shan Medical University, No. 110, Sec. 1, Jianguo North Road, Taichung 402, Taiwan. - - 2014
The present study was undertaken to evaluate the hepatoprotective effect mechanisms of Nelumbo nucifera leaves extract (NLE) in experimental alcoholic steatohepatitis animal models. We found that the NLE contained polyphenols (phenolic acids and flavonoids), and more than 70% of the main functional components in NLE could potentially provide benefits for ...
Kimura Mitsutoshi M Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Josai - - 2014
The effects of L-ascorbic acid and its stable analogue L-ascorbic acid 2-glucoside on the restoration of liver mass and recovery of liver function after 70% partial hepatectomy (PH), were compared with other natural vitamin C analogues in rats in vivo. L-ascorbic acid (100 mg/kg/day, i.p.)- and L-ascorbic acid 2-glucoside (50 ...
Bushee Jennifer L JL Department of Metabolism and Pharmacokinetics, Novartis Institutes for BioMedical Research Inc. , Cambridge, MA , USA - - 2014
Abstract 1. In vitro clearance in liver microsomes is routinely measured in drug discovery and development for new chemical entities. Literature reports indicate that long chain fatty acids such as arachidonic, linoleic and oleic acids may be released over a period of time during microsomal incubations. Some fatty acids have been ...
Monteiro Jessica J Department of Human Health and Nutritional Sciences, College of Biological Science, 491 Gordon Street, University of Guelph, Animal Science/Nutrition Building, Room 342, Guelph, Ontario N1G 2W1, Canada. davidma@uoguelph.ca monteirj@uoguelph.ca - - 2014
Cardiovascular disease (CVD) and non-alcoholic fatty liver disease (NAFLD) are manifestations of the metabolic syndrome. CVD remains the number one cause of mortality in the West, while NAFLD is the most common liver disease. Growing evidence suggests that polyunsaturated fatty acids (PUFA) influence risk factors including circulating lipids and inflammation ...
Shao Fei F Edward A. Doisy Department of Biochemistry and Molecular Biology, Center for Cardiovascular Research, Saint Louis University School of Medicine, St. Louis, MO, 63104, - - 2014
The liver is the major organ responsible for lipid biosynthesis. Sterol regulatory element-binding proteins (SREBP) are major transcription factors that regulate the expression of genes regulating fatty acid and cholesterol biosynthesis. Here we show that elaidic acid upregulates hepatic de-novo fatty acid and cholesterol synthesis in HuH-7 cells. To define ...
Pauter Anna M AM The Wenner-Gren Institute, - - 2014
The potential role of endogenously synthesized polyunsaturated fatty acids (PUFAs) is a highly overlooked area. Elongation of very long chain (ELOVL) fatty acids in mammals is catalyzed by the ELOVL enzymes to which the PUFA elongase ELOVL2 belongs. To determine its in vivo function, we have investigated how ablation of ...
Liu Lei L Cornell University, United - - 2014
Long chain polyunsaturated fatty acids occur in foods primarily in the natural lipid classes triacylglycerols (TAG) or phospholipids (PL). We studied the relative efficacy of the neural omega-3 docosahexaenoic acid (DHA) provided in formula to the growing piglet as a dose of 13C-DHA bound to either TAG or phosphatidylcholine (PC). ...
Cockbain Andrew J AJ Section of Molecular Gastroenterology, Leeds Institute of Biomedical & Clinical Sciences, St James's University Hospital, , Leeds, - - 2014
Oral administration of the omega-3 fatty acid eicosapentaenoic acid (EPA), as the free fatty acid (FFA), leads to EPA incorporation into, and reduced growth of, experimental colorectal cancer liver metastases (CRCLM). We performed a Phase II double-blind, randomised, placebo-controlled trial of EPA-FFA 2 g daily in patients undergoing liver resection ...
Stanković Milena N MN Faculty of Medicine, Institute of Pathophysiology "Ljubodrag Buba Mihailović", University of Belgrade, - - 2014
Methionine-choline deficient (MCD) diet duration necessary for development of non-alcoholic fatty liver disease (NAFLD) and the dynamic of lipid profile and fatty acids are not completely established. The study examined dynamics and association between liver free fatty acids (FFA), serum lipid profile and liver morphological changes on MCD diet-induced NAFLD ...
Tabata Mitsuhisa M Department of Cancer Biology, Dana-Farber Cancer Institute - - 2014
Hepatic ketogenesis plays an important role in catabolism of fatty acids during fasting as well as dietary lipid overload, but the mechanisms regulating this process remain poorly understood. Here, we show that Cdc2-like kinase 2 (Clk2) suppresses fatty acid oxidation and ketone body production during diet-induced obesity. In lean mice, ...
Jia Xiaofang X Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, Nagoya, 466-8550, - - 2014
Our previous study indicated that hepatic bile acids (BAs) may have deposited and stimulated the pathogenesis of a high fat-cholesterol (HFC) diet-induced fibrotic steatohepatitis in stroke-prone spontaneously hypertensive 5/Dmcr rats, based on dysregulated BA homeostasis pathways. We aimed to further characterize BA profiles in liver and evaluate their relationships to ...
Zhang Li-Fang LF State Key Laboratory of Natural Medicines, Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing 210009, - - 2014
Aim:To investigate the potential interactive effects of a high-fat diet (HFD) and valproic acid (VPA) on hepatic steatosis and hepatotoxicity in rats.Methods:Male SD rats were orally administered VPA (100 or 500 mg·kg(-1)·d(-1)) combined with HFD or a standard diet for 8 weeks. Blood and liver samples were analyzed to determine ...
Tian Chang-Rong CR Department of Geriatrics, The Second People's Hospital of Lianyungang, 41 East Hailian Road, Xinpu, 222006, - - 2014
Uric acid is the end product of nucleic acid catabolism for humanity. Serum uric acid level has been suggested to be associated with nonalcoholic fatty liver disease (NAFLD). This study aims to examine the association between serum uric acid levels and NAFLD in subjects of different ages. A cross-sectional study ...
Dick Morag F - - 2014
Rapid body fat mobilization, obesity, and an inadequate supply of n-3 polyunsaturated fatty acids (PUFA) have been suggested to play roles in the etiology of fatty liver in the American mink (Neovison vison). This study examined the effects of feeding intensity and dietary fat source on fatty liver induced by ...
Xu Guan G From the Department of Radiology (G.X., P.L.C., B.J., X.W.) and Life Sciences Institute and Department of Cell and Developmental Biology (Z.X.M., J.D.L.), University of Michigan, 1301 Catherine St, Ann Arbor, MI 48109; and School of Electronic Science and Engineering, Nanjing University, Nanjing, Jiangsu, China - - 2014
Purpose To investigate the use of photoacoustic (PA) spectrum analysis (PASA) to identify microstructural changes corresponding to fat accumulation in mouse livers ex vivo and in situ. Materials and Methods The laboratory animal protocol for this work was approved by the university committee on use and care of animals. Six ...
Ding Ying Y Department of Radiology, Zhongshan Hospital of Fudan University, No180, Fenglin Road, Xuhui District, Shanghai, China, 200032. Electronic address: - - 2014
The aim of this study was to compare the diagnostic performance of gadopentetate dimeglumine and gadoxetic-acid-enhanced MRI in patients with colorectal liver metastases. Thirty patients were included and divided into three sets, as follows: gadopentetate dimeglumine set-hepatic arterial phase, portal venous phase, and delay phase; gadoxetic acid set-hepatic arterial phase, ...
Rebollo Alba A Department of Pharmacology and Therapeutic Chemistry, School of Pharmacy, University of - - 2014
Fructose ingestion is associated with the production of hepatic steatosis and hypertriglyceridaemia. For fructose to attain these effects in rats, simultaneous induction of fatty acid synthesis and inhibition of fatty acid oxidation is required. We aimed to determine the mechanism involved in the inhibition of fatty acid oxidation by fructose ...
Reynolds Lacy L Advanced Imaging Research Center, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390, - - 2014
Aim: The natural omega-3 polyunsaturated fatty acid, docosahexaenoic acid (DHA), has recently been credited for possessing anticancer properties. Herein, we investigate the cytotoxic actions of DHA-loaded low-density lipoprotein (LDL) nanoparticles in normal and liver cancer cells. Materials & methods: LDL-DHA nanoparticles were prepared and subjected to extensive biophysical characterization. The ...
Mandal Samir S Cell Biology & Physiology Division, CSIR - Indian Institute of Chemical Biology, 4, Raja S.C. Mullick Road, Kolkata 700032, - - 2014
Andrographis paniculata (AP) is a traditional medicinal plant of Ayurveda. It grows widely in Asia and is prescribed in the treatment of liver diseases. Here we have investigated the beneficial role of 14-deoxyandrographolide (14-DAG), a bioactive diterpenoid from AP, against alcoholic steatosis in rats. 14-DAG was extracted from aerial parts (leaves ...
Karahashi Minako M Faculty of Pharmaceutical Sciences, Josai - - 2014
Fibrates are used in biochemical and pharmacological studies as bioactive tools. Nevertheless, most studies have lacked information concerning the concentrations of fibric acids working inside tissues because a simple and sensitive method is not available for their quantitation. This study aimed to develop a simple and sensitive bioanalytical method for ...
Le Thuc T TT Nevada Cancer Institute, Las Vegas, Nevada, United States of America ; Desert Research Institute, Las Vegas, Nevada, United States of - - 2014
Uridine, a pyrimidine nucleoside, can modulate liver lipid metabolism although its specific acting targets have not been identified. Using mice with fenofibrate-induced fatty liver as a model system, the effects of uridine on liver lipid metabolism are examined. At a daily dosage of 400 mg/kg, fenofibrate treatment causes reduction of ...
Cai Wen W School of Nursing, Xinjiang Medical University, No. 168 Youhao South Road, Urumqi, Xinjiang 830000, - - 2014
Objective. To investigate the prevalence of nonalcoholic fatty liver disease (NAFLD) and the association of serum uric acid level with NAFLD in Uygur people, Xinjiang. Methods. A total of 2241 Uyghur persons (1214 males and 1027 females) were interviewed for physical checkups from 2011 to 2012. The clinical data of ...
Martinez M Del C Mdel C Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Intendente Guiraldes 2160 Pab II, 1428 Buenos Aires, - - 2014
Erythropoietic protoporphyria (EPP) is a disease associated with ferrochelatase deficiency and characterized by the accumulation of protoporphyrin IX (PROTO IX) in erythrocytes, liver, and skin. In some cases, a severe hepatic failure and cholestasis were observed. Griseofulvin (Gris) develops an experimental EPP with hepatic manifestations in mice such as PROTO ...
Gladine Cécile C UMR1019 Unité de Nutrition Humaine (UNH), INRA, CRNH Auvergne, Clermont Université, Université d'Auvergne, Clermont-Ferrand, - - 2014
The anti-atherogenic effects of omega 3 fatty acids, namely eicosapentaenoic (EPA) and docosahexaenoic acids (DHA) are well recognized but the impact of dietary intake on bioactive lipid mediator profiles remains unclear. Such a profiling effort may offer novel targets for future studies into the mechanism of action of omega 3 ...
Meher Akshaya A Department of Nutritional Medicine, Interactive Research School for Health Affairs, Bharati Vidyapeeth University, Pune, Maharashtra, - - 2014
Nutritional status of the mother is known to influence various metabolic adaptations required for optimal fetal development. These may be mediated by transcription factors like peroxisome proliferator activated receptors (PPARs), which are activated by long chain polyunsaturated fatty acids. The objective of the current study was to examine the expression ...
Agbaga Martin-Paul MP Departments of Ophthalmology, University of Oklahoma Health Sciences Center, 73104, Oklahoma City, OK, USA, - - 2014
Elongation of Very Long chain fatty acids-4 (ELOVL4) is a fatty acid condensing enzyme that mediates biosynthesis of very long chain polyunsaturated fatty acids (VLC-PUFA; ≥ C28) in a limited number of tissues. Depletion of VLC-PUFA in retinal photoreceptors leads to retinal dysfunction and likely contributes to autosomal dominant Stargardt-like macular ...
Fisk Helena L HL Human Development & Health Academic Unit, Faculty of Medicine, University of Southampton; - - 2014
Gas chromatography (GC) is a highly sensitive method used to identify and quantify the fatty acid content of lipids from tissues, cells, and plasma/serum, yielding results with high accuracy and high reproducibility. In metabolic and nutrition studies GC allows assessment of changes in fatty acid concentrations following interventions or during ...
Kessler Sonja M SM Department of Pharmacy, Pharmaceutical Biology, Saarland University, Campus C2 2, 66123 Saarbrücken, Germany. - - 2014
Non-alcoholic steatohepatitis (NASH) represents a risk factor for the development of hepatocellular carcinoma (HCC) and is characterized by quantitative and qualitative changes in hepatic lipids. Since elongation of fatty acids from C16 to C18 has recently been reported to promote both hepatic lipid accumulation and inflammation we aimed to investigate ...
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