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Ide Takashi T Laboratory of Nutritional Function, National Food Research Institute, 2-1-12 Kannondai, Tsukuba 305-8642, - - 2014
In the present study, the mRNA levels of hepatic proteins involved in the drug metabolism of rats fed α-lipoic acid were evaluated by DNA microarray and real-time PCR analyses. Experimental diets containing 0, 0·1, 0·25 and 0·5 % (w/w) α-lipoic acid were fed to four groups of rats consisting of seven ...
Jacome-Sosa M Miriam MM Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri, - - 2014
Different sources of fatty acids (FA) used for VLDL-triglyceride synthesis include dietary FA that clear to the liver via chylomicron uptake, FA synthesized de novo in the liver from carbohydrates, nonesterified fatty acids derived from adipose tissue, nonesterified fatty acids derived from the spillover of chylomicron-triglyceride in the fasted and ...
Lands Bill B ASN, AAAS, SFRBM, College Park, MD, USA. Electronic address: - - 2014
Current public advice from the Food and Nutrition Board (FNB) about essential fatty acids (EFA) has limited quantitative details about three processes: 1.- similar dynamics for n-3 linolenic and n-6 linoleic polyunsaturated fatty acids (PUFA) in maintaining 20- and 22-carbon n-3 and n-6 highly unsaturated fatty acids (HUFA) in tissues; ...
Li Heng-Hong HH Department of Biochemistry and Molecular & Cellular Biology, Georgetown University, Washington, District of - - 2014
Chronic alcohol intake affects liver function and causes hepatic pathological changes. It has been shown that peroxisome proliferator-activated receptor α (PPARα)-null mice developed more pronounced hepatic changes than wild-type (WT) mice after chronic exposure to a diet containing 4% alcohol. The remarkable similarity between the histopathology of alcoholic liver disease ...
Heebøll Sara S Sara Heebøll, Karen Louise Thomsen, Hendrik Vilstrup, Henning Grønbæk, Department of Hepatology and Gastroenterology, Aarhus University Hospital, 8000 Aarhus C, - - 2014
The prevalence of obesity and related conditions like non-alcoholic fatty liver disease (NAFLD) is increasing worldwide and therapeutic options are limited. Alternative treatment options are therefore intensively sought after. An interesting candidate is the natural polyphenol resveratrol (RSV) that activates adenosinmonophosphate-activated protein kinase (AMPK) and silent information regulation-2 homolog 1 ...
Zhang Hong-Li HL Zhejiang Provincial Key Laboratory of Biometrology and Inspection & Quarantine, Department of Pharmacy, College of Life Sciences, China Jiliang - - 2014
Hepatitis B is the most common serious liver infection in the world. To date, there is still no complete cure for chronic hepatitis B. Natural caffeic acid analogues possess prominent antiviral activity, especially anti-HBV and anti-HIV effects. Cichoric acid is a caffeic acid derivative from Cichorium intybus. In the study, ...
Yu Zhen Z Department of Biochemistry and Biophysics, Linus Pauling Institute, Oregon State University, 307 Linus Pauling Science Center, Corvallis, OR 97331. - - 2014
Dietary restriction (DR) is the gold standard intervention used to delay aging, and much recent research has focused on the identification of possible DR mimetics. Energy sensing pathways, including insulin/IGF1 signaling, sirtuins, and mammalian Target of Rapamycin (mTOR), have been proposed as pathways involved in the antiaging actions of DR, ...
Laggai Stephan S Saarland University, Pharmaceutical Biology, - - 2014
Liver-specific overexpression of the insulin-like growth factor 2 (IGF2) mRNA binding protein p62/IGF2BP2-2 induces a fatty liver, which highly expresses IGF2. Since IGF2 expression is elevated in patients with steatohepatitis, the aim of our study was to elucidate the role and interconnection of p62 and IGF2 in lipid metabolism. Expression ...
Bisogno Tiziana T Endocannabinoid Research Group, Institute of Biomolecular Chemistry, National Research Council, 80078, Pozzuoli, Italy; Center of Integrated Research, Campus Bio-Medico University of Rome, 00128, Rome, - - 2014
Diet plays a central role in maintaining health throughout life and a controlled food intake is associated to a reduced risk of certain diseases. A proper diet should include vitamins, minerals, carbohydrates, proteins, and fats that have to be optimally balanced in order to exert their physiological functions. The endogenous ...
Rood Jennifer C JC Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana, USA. Electronic address: - - 2014
Botanical compounds and extracts are widely used as nutritional supplements for the promotion of health or the prevention of disease. An extract of Artemisia dracunculus (PMI 5011) has been shown to improve insulin action, yet the precise mechanism is not known. The aim of this study is to demonstrate that ...
Kawano Yuki Y Department of Medicine, Division of Gastroenterology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, - - 2014
Thioesterase superfamily member 2 (Them2) is a mitochondrion-associated long-chain fatty acyl coenzyme A (CoA) thioesterase that is highly expressed in the liver and oxidative tissues. Them2 activity in vitro is increased when it interacts with phosphatidylcholine transfer protein (PC-TP), a cytosolic lipid binding protein. Them2-/- and Pctp-/- mice exhibit enhanced ...
Zhang Tianshun T Department of Agrobioscience, Graduate School of Agricultural Science, Kobe University, Kobe 657-8501, Japan. - - 2014
Excessive lipid accumulation in the liver has been proposed to cause hyperlipidemia, diabetes and fatty liver disease. 4-Hydroxyderricin (4HD), xanthoangelol (XAG), cardamonin (CAR) and flavokawain B (FKB) are chalcones that have exhibited various biological effects against obesity, inflammation, and diabetes; however, little is known about the inhibitory effects of these ...
Della Corte Claudia C Hepato-Metabolic Disease Unit and Liver Research Unit, "Bambino Gesù" Children's Hospital, IRCCS, P.le S. Onofrio 4, 00165 Rome, - - 2014
Central obesity represents the major factor responsible for NAFLD, but several immunological and endocrinological mechanisms are involved in fatty infiltration in the liver, inflammation and fibrosis. Gut microbiota and genetic factors were recently indicated as major players in liver injury. Loss of weight and physical activity represent till now the ...
Saito Hiroaki H National Research Institute of Fisheries Science, Fisheries Research - - 2014
The lipid and fatty acid compositions of the muscle and liver of five Epinephelinae fishes (Epinephelus fasciatus, Epinephelus retouti, Cephalopholis aurantia, Cephalopholis miniatus, and Variola louti) in the coral reef were investigated. The major polyunsaturated fatty acid (PUFA) in the Epinephelinae fish triacylglycerols was 22:6n-3 (docosahexaenoic acid; DHA), which was ...
Durairaj Varalakshmi V Department of Biochemistry and Molecular Biology, School of Life Sciences, Pondicherry University, Puducherry, 605014, - - 2014
Alcoholism is a broad term used for problems related to alcohol, medically considered as disease, specifically an addictive illness, abuse, and dependence. It is the major cause of liver disease in western countries. Alcoholic liver disease encompasses the hepatic alterations leading to fatty liver, hepatitis, and fibrosis or cirrhosis. Fried ...
Tang Maoxue M Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing, 100193, People's Republic of - - 2014
Genetically modified animals rich in omega-3 unsaturated fatty acid offer a new strategy to improve the human health, but at the same time present a challenge in terms of food safety assessment. In this study, we evaluated the function and safety of sFat-1 transgenic pork rich in omega-3 fatty acids ...
Arakawa Yusuke Y Assistant Professor, Institute of Health Biosciences, Department of Surgery, The University of Tokushima Graduate School 3-18-15 Kuramoto, Tokushima 770-8503, Japan. - - 2014
Oxaliplatin-based chemotherapy can cause hepatic sinusoidal injury such as sinusoidal obstructive syndrome (SOS). Spleen size is correlated with sinusoidal damage, and serum hyaluronic acid is also a marker of SOS. The aim of the present study was to clarify the impact of the current chemotherapeutic regimen plus bevacizumab against oxaliplatin-associated ...
Kan Shidong S State Key Lab of New Drug and Pharmaceutical Processes, Shanghai Inst. of Pharmaceutical Industry, Nr. 1320, West Beijing Rd, Shanghai, 200040, - - 2014
Salvianolic acid A (Sal A) was considered to be the compound with highest activity in Salvia miltiorrhiza (danshen). Due to its low content in raw materials, many studies reported its preparation from salvianolic acid B (Sal B). However, the process of this transformation is still unknown. Our objective was to ...
Basili Stefania S First Medical Clinic (Department of Internal Medicine and Medical Specialties), Sapienza-University of Rome, - - 2014
NADPH-oxidase-2 up-regulation has been suggested in liver damage perpetuation via an oxidative stress-mediated mechanism. n-6/n-3 polyunsaturated fatty acids ratio derangement has been reported in liver disease. To explore polyunsaturated fatty acids balance and its interplay with platelet oxidative stress in liver cirrhosis. A cross-sectional study in 51 cirrhotic patients and ...
Huang Qiaoyan Q Institute of Evolution & Marine Biodiversity and Department of Marine Biology, Ocean University of - - 2014
Gpr84 was recently identified as a receptor for medium-chain fatty acids, but its functions remain to be clarified. We reported the identification of a zebrafish Gpr84 homologue (zGpr84), which has a higher gene expression in the tissues of intestine, heart and liver. During embryogenesis, zGpr84 is maternally expressed and a ...
Surapaneni Krishna Mohan KM Department of Biochemistry, Saveetha Medical College and Hospital, Faculty of Medicine, Saveetha University, Chennai, Tamil Nadu, - - 2014
Non alcoholic steatohepatitis (NASH), severe form of diseases belonging to the spectrum of the Non alcoholic fatty liver disease (NAFLD). It is an asymptomatic disease which leads to fibrosis and finally to cirrhosis, an end stage liver disease. To study the effect of pioglitazone, quercetin and hydroxy citric acid on ...
Jia Lina L Shanghai Institute of Applied Physics (SINAP), Chinese Academy of Sciences, Shanghai 201800, P. R. China; Graduate University of the Chinese Academy of Sciences, 19A Yuquan Road, Beijing 100049, P. R. - - 2014
The farnesoid-X-receptor (FXR) is a member of the nuclear hormone receptor superfamily. The FXR has critical functions in maintaining bile acid synthesis and homeostasis, liver regeneration and tumorigenesis, intestinal diseases, intestinal tumorigenesis, cholesterol gallstone disease, cholestasis, and atherosclerosis. FXR expression is strongly downregulated in liver fibrosis, hepatocellular adenoma and hepatocellular ...
Zhang Qinghao Q Marine Biology Institute & Guangdong Provincial Key Laboratory of Marine Biotechnology, Shantou University, Shantou, Guangdong, - - 2014
Biosynthesis in vertebrates of long-chain polyunsaturated fatty acids (LC-PUFA) such as arachidonic (ARA; 20:4n-6), eicosapentaenoic (EPA; 20:5n-3) and docosahexaenoic (DHA; 22:6n-3) acids requires the catalysis by fatty acyl desaturases (Fad). A vertebrate Fad with Δ4 activity, catalyzing the direct conversion of 22:5n-3 to DHA was discovered in the marine teleost ...
Ding X X Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, PR - - 2014
Abnormal fatty acid oxidation (FAO) and lipid metabolism have been found related to preeclampsia (PE). Antiphospholipid syndrome (APS) as a clinical risk factor for PE has also been reported with abnormal lipid metabolism. However, the role of FAO in PE accompanied with APS is unknown. We aimed to investigate long-chain ...
Dai Dongling D Clinical and Molecular Genetics Unit, UCL Institute of Child Health, London, WC1N 1EH, - - 2014
A child of consanguineous parents of Pakistani origin developed jaundice at 5 weeks and then, at 3 months, irritability, a prolonged prothrombin time, a low albumin, and episodes of hypoglycaemia. Investigation showed an elevated alanine aminotransferase with a normal γ-glutamyl-transpeptidase. Analysis of urine by electrospray ionisation tandem mass spectrometry (ESI-MS/MS) showed that ...
Huang Huan H Department of Physiology and Pharmacology, Texas A&M University, TVMC College Station, TX, - - 2014
The human liver fatty acid binding protein (L-FABP) T94A variant, the most common in the FABP family, has been associated with elevated liver triglyceride (TG) levels. How this amino acid substitution elicits these effects is not known. This issue was addressed with human recombinant wild-type (WT, T94T) and T94A variant ...
da Costa Ana Sofia - - 2014
In ruminants, unsaturated dietary fatty acids are biohydrogenated in the rumen and are further metabolised in various tissues, including liver, which has an important role in lipid and lipoprotein metabolism. Therefore, manipulation of muscle fatty acid composition should take into account liver metabolism. In the present study, the influence of ...
Cho Hyun Kook HK Department of Molecular Biology, Pusan National University, Busan, 609-735, - - 2014
The protein level of human hepatitis B virus (HBV) in infection is variable dependent on patient context. We previously reported that HBV X protein (HBx) induces hepatic lipid accumulation and inflammation. Here, we show that abnormal levels of hepatic fatty acids increase HBx protein stability during HBV expression, resulting in ...
Tu Qian-Qian QQ International Co-operation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Institute, Second Military Medical University, Shanghai 200433, - - 2014
Aim:Free fatty acid-induced lipotoxicity plays a crucial role in the progression of nonalcoholic fatty liver disease (NAFLD). In the present study we investigated the effects of a high-fat diet and free fatty acids on the autophagic process in hepatocytes in vivo and in vitro and the underlying mechanisms.Methods:LC3-II expression, a ...
Sahini Nishika N Centre for Pharmacology and Toxicology, Hannover Medical School, 30625 Hannover, - - 2014
Triacyglycerols are a major energy reserve of the body and are normally stored in adipose tissue as lipid droplets (LDs). The liver, however, stores energy as glycogen and digested triglycerides in the form of fatty acids. In stressed condition such as obesity, imbalanced nutrition and drug induced liver injury hepatocytes ...
Kersten Sander S Nutrition, Metabolism and Genomics Group, Wageningen University, Bomenweg 2, 6703HD Wageningen, The - - 2014
The Peroxisome Proliferator Activated Receptor alpha (PPARα) is a transcription factor that plays a major role in metabolic regulation. This review addresses the functional role of PPARα in intermediary metabolism and provides a detailed overview of metabolic genes targeted by PPARα, with a focus on liver. A distinction is made ...
Guariento Aline H AH Laboratory of Diet, Nutrition, and Cancer, Department of Food and Experimental Nutrition, University of São Paulo, São Paulo, - - 2014
The steady increase in the incidence and mortality of hepatocellular carcinoma (HCC) signifies a crucial need to understand better its pathogenesis to improve clinical management and prevention of the disease. The aim of this study was to investigate molecular mechanisms for the chemopreventive effects of folic acid and tributyrin alone ...
Li Xinwei X Key Laboratory of Zoonosis, Ministry of Education, College of Veterinary Medicine, Jilin University, 5333 Xi'an Road, Changchun, Jilin, 130062, - - 2014
The natural incidence of fatty liver in ruminants is significantly higher than in monogastric animals. Fatty liver is associated with sterol regulatory element-binding protein 1c (SREBP-1c). The aim of this study was to investigate the regulatory network effects of SREBP-1c on the lipid metabolic genes involved in fatty acid uptake, ...
Yan Hu H 1Department of Pharmacology, Dalian Medical University, Dalian, China. 2Department of Pharmacy, Second Affiliated Hospital of Dalian Medical University, Dalian, China. 3Department of General Surgery, Second Affiliated Hospital of Dalian Medical University, Dalian, - - 2014
Ischemia/reperfusion is a leading cause of liver damage after surgical intervention, trauma, and transplantation. It has been reported that the nicotinamide adenine dinucleotide-dependent deacetylase sirtuin 1 attenuates myocardial, cerebral, and renal ischemia/reperfusion damage. This study aimed to investigate the involvement of sirtuin 1-mediated p66shc inhibition in liver ischemia/reperfusion and explore ...
Kratzer James T JT School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA - - 2014
Uricase is an enzyme involved in purine catabolism and is found in all three domains of life. Curiously, uricase is not functional in some organisms despite its role in converting highly insoluble uric acid into 5-hydroxyisourate. Of particular interest is the observation that apes, including humans, cannot oxidize uric acid, ...
Scorletti E E Human Development and Health Academic Unit, Faculty of Medicine, University of Southampton, Southampton, UK. Electronic address: - - 2014
Non-alcoholic fatty liver disease (NAFLD) represents a range of liver conditions from simple fatty liver to progressive end stage liver disease requiring liver transplantation. NAFLD is common in the population and in certain sub groups (e.g. type 2 diabetes) up to 70% of patients may be affected. NAFLD is not ...
Rogue Alexandra A Inserm UMR 991, F-35043 Rennes cedex, France; Université de Rennes 1, Faculté des Sciences Pharmaceutiques et Biologiques, 35043 Rennes cedex, France; Biologie Servier, Gidy, - - 2014
Although non-alcoholic fatty liver disease (NAFLD) is currently the most common form of chronic liver disease there is no pharmacological agent approved for its treatment. Since peroxisome proliferator-activated receptors (PPARs) are closely associated with hepatic lipid metabolism, they seem to play important roles in NAFLD. However, the effects of PPAR ...
Tang Chang-Chieh CC Institute of Biochemistry and Biotechnology, College of Medicine, Chung Shan Medical University, No. 110, Sec. 1, Jianguo North Road, Taichung 402, Taiwan. - - 2014
The present study was undertaken to evaluate the hepatoprotective effect mechanisms of Nelumbo nucifera leaves extract (NLE) in experimental alcoholic steatohepatitis animal models. We found that the NLE contained polyphenols (phenolic acids and flavonoids), and more than 70% of the main functional components in NLE could potentially provide benefits for ...
Bushee Jennifer L JL Department of Metabolism and Pharmacokinetics, Novartis Institutes for BioMedical Research Inc. , Cambridge, MA , USA - - 2014
Abstract 1. In vitro clearance in liver microsomes is routinely measured in drug discovery and development for new chemical entities. Literature reports indicate that long chain fatty acids such as arachidonic, linoleic and oleic acids may be released over a period of time during microsomal incubations. Some fatty acids have been ...
Monteiro Jessica J Department of Human Health and Nutritional Sciences, College of Biological Science, 491 Gordon Street, University of Guelph, Animal Science/Nutrition Building, Room 342, Guelph, Ontario N1G 2W1, Canada. davidma@uoguelph.ca monteirj@uoguelph.ca - - 2014
Cardiovascular disease (CVD) and non-alcoholic fatty liver disease (NAFLD) are manifestations of the metabolic syndrome. CVD remains the number one cause of mortality in the West, while NAFLD is the most common liver disease. Growing evidence suggests that polyunsaturated fatty acids (PUFA) influence risk factors including circulating lipids and inflammation ...
Shao Fei F Edward A. Doisy Department of Biochemistry and Molecular Biology, Center for Cardiovascular Research, Saint Louis University School of Medicine, St. Louis, MO, 63104, - - 2014
The liver is the major organ responsible for lipid biosynthesis. Sterol regulatory element-binding proteins (SREBP) are major transcription factors that regulate the expression of genes regulating fatty acid and cholesterol biosynthesis. Here we show that elaidic acid upregulates hepatic de-novo fatty acid and cholesterol synthesis in HuH-7 cells. To define ...
Pauter Anna M AM The Wenner-Gren Institute, - - 2014
The potential role of endogenously synthesized polyunsaturated fatty acids (PUFAs) is a highly overlooked area. Elongation of very long chain (ELOVL) fatty acids in mammals is catalyzed by the ELOVL enzymes to which the PUFA elongase ELOVL2 belongs. To determine its in vivo function, we have investigated how ablation of ...
Liu Lei L Cornell University, United - - 2014
Long chain polyunsaturated fatty acids occur in foods primarily in the natural lipid classes triacylglycerols (TAG) or phospholipids (PL). We studied the relative efficacy of the neural omega-3 docosahexaenoic acid (DHA) provided in formula to the growing piglet as a dose of 13C-DHA bound to either TAG or phosphatidylcholine (PC). ...
Cockbain Andrew J AJ Section of Molecular Gastroenterology, Leeds Institute of Biomedical & Clinical Sciences, St James's University Hospital, , Leeds, - - 2014
Oral administration of the omega-3 fatty acid eicosapentaenoic acid (EPA), as the free fatty acid (FFA), leads to EPA incorporation into, and reduced growth of, experimental colorectal cancer liver metastases (CRCLM). We performed a Phase II double-blind, randomised, placebo-controlled trial of EPA-FFA 2 g daily in patients undergoing liver resection ...
Stanković Milena N MN Faculty of Medicine, Institute of Pathophysiology "Ljubodrag Buba Mihailović", University of Belgrade, - - 2014
Methionine-choline deficient (MCD) diet duration necessary for development of non-alcoholic fatty liver disease (NAFLD) and the dynamic of lipid profile and fatty acids are not completely established. The study examined dynamics and association between liver free fatty acids (FFA), serum lipid profile and liver morphological changes on MCD diet-induced NAFLD ...
Tabata Mitsuhisa M Department of Cancer Biology, Dana-Farber Cancer Institute - - 2014
Hepatic ketogenesis plays an important role in catabolism of fatty acids during fasting as well as dietary lipid overload, but the mechanisms regulating this process remain poorly understood. Here, we show that Cdc2-like kinase 2 (Clk2) suppresses fatty acid oxidation and ketone body production during diet-induced obesity. In lean mice, ...
Jia Xiaofang X Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, Nagoya, 466-8550, - - 2014
Our previous study indicated that hepatic bile acids (BAs) may have deposited and stimulated the pathogenesis of a high fat-cholesterol (HFC) diet-induced fibrotic steatohepatitis in stroke-prone spontaneously hypertensive 5/Dmcr rats, based on dysregulated BA homeostasis pathways. We aimed to further characterize BA profiles in liver and evaluate their relationships to ...
Zhang Li-Fang LF State Key Laboratory of Natural Medicines, Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing 210009, - - 2014
Aim:To investigate the potential interactive effects of a high-fat diet (HFD) and valproic acid (VPA) on hepatic steatosis and hepatotoxicity in rats.Methods:Male SD rats were orally administered VPA (100 or 500 mg·kg(-1)·d(-1)) combined with HFD or a standard diet for 8 weeks. Blood and liver samples were analyzed to determine ...
Tian Chang-Rong CR Department of Geriatrics, The Second People's Hospital of Lianyungang, 41 East Hailian Road, Xinpu, 222006, - - 2014
Uric acid is the end product of nucleic acid catabolism for humanity. Serum uric acid level has been suggested to be associated with nonalcoholic fatty liver disease (NAFLD). This study aims to examine the association between serum uric acid levels and NAFLD in subjects of different ages. A cross-sectional study ...
Dick Morag F - - 2014
Rapid body fat mobilization, obesity, and an inadequate supply of n-3 polyunsaturated fatty acids (PUFA) have been suggested to play roles in the etiology of fatty liver in the American mink (Neovison vison). This study examined the effects of feeding intensity and dietary fat source on fatty liver induced by ...
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