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Lin Meei-Hua MH Renal Division and Washington University School of Medicine, St. Louis, Missouri, - - 2014
Fatty acid transport protein (FATP) 4 is one of a family of six FATPs that facilitate long- and very long-chain fatty acid uptake. Mice lacking FATP4 are born with tight, thick skin and a defective barrier; they die neonatally due to dehydration and restricted movements. Mutations in SLC27A4, the gene ...
Piérard G E GE Laboratory of Skin Bioengineering and Imaging, Department of Clinical Sciences, University of Liège, Liège, - - 2014
α-Hydroxy acid (AHA) formulations are commonly used for skin chemical peelings. The primary target is the stratum corneum (SC). The aim of this study was to assess the effects of various glycolic acid concentrations and commercial phenolic acid formulations on the SC. Quantitative colorimetry of a corneoxenometry bioassay was used. ...
Mateus Rita R Department of Pharmaceutics, UCL School of Pharmacy, 29-39 Brunswick Square, London, WC1 N 1AX, United - - 2014
Salicylic acid (SA) has been used in pharmaceutical and cosmetic preparations for many years. Although there are a number of studies which report on the permeation characteristics of this molecule in vitro, to our knowledge the disposition of SA in vivo has not been studied in detail. In the present ...
Sudre Guillaume G Laboratoire de Science et Ingénierie de la Matière Molle, UMR 7615 CNRS/UPMC/ESPCI ParisTech, 10 rue Vauquelin, F-75231 Paris Cedex 5, - - 2014
We investigated the effect of specific interactions on the structure of interfaces between a brush and a hydrogel on the polymer chain length scale. We used a model system for which the interactions between the brush and the gel are switchable. We synthesized weak polyelectrolyte brushes of poly(acrylic acid) and ...
Sila Assaâd A Unité Enzyme et Bioconversion, ENIS, University of Sfax, - - 2015
The characteristics and functional properties of gelatine from freshwater fish skin (Barbus callensis) were investigated. The gelatine extraction efficiency was improved by an acid-swelling process in the presence of barbel crude acid protease extract. Barbel skin gelatine (BSG) contained 92.15% protein, 0.31% lipid and 0.72% ash. The amino acid profile ...
Carbonell-Barrachina Angel A AA Food Quality and Safety Group, Agro-Food Technology Department, Superior Polytechnic Engineering School, Universidad Miguel Hernández de Elche, Ctra. Beniel, km 3.2, 03312 Orihuela, Alicante, - - 2015
Phytochemical profiles of 24 quince liquors were studied as the combination of technologically variant. Liquors were obtained after macerating quinces from three varieties (Vranja, ALM3 and ZM2), with or without skin, at two ratios of quince:ethanol (50:50 and 25:75), and at two alcohol content (60% and 30%). Polyphenols were identified ...
Ricciardi Roberto - - 2014
Sulfonic acid-bearing polymer brushes were grown on the inner walls of continuous flow glass microreactors and used in the acid-catalyzed hydrolysis of benzaldehyde dimethyl acetal as a test reaction. Randomly 1:1 mixed polymer brushes of poly-3-sulfopropyl methacrylate (PSPM) and poly-2-hydroxyethyl methacrylate (PHEMA) showed a 6-fold increase of the TOF value ...
Joshi Kalpana S KS Department of Biotechnology, Sinhgad College of Engineering, Pune, Maharashtra, - - 2014
Ghee (clarified butter) also known as ghrita, has been utilized for thousands of years in Ayurveda. Ghee is mostly prepared by traditional method in Indian households or by direct cream method at industry level. Ayurvedic classics mention that ghrita made from cow milk is superior. However, there is no scientific ...
Gültekin Aytaç A Department of Energy Systems Engineering, Faculty of Engineering, Karamano─člu Mehmetbey University, Karaman 70200, Turkey. Electronic address: - - 2014
In the present work, a new caffeic acid imprinted quartz crystal microbalance (QCM) nanosensor has been designed for selective assignation of caffeic acid in plant materials. Methacrylamidoantipyrine-iron(III) [MAAP-Fe(III)] as metal-chelating monomer has been used to prepare selective molecular imprinted polymer (MIP). MIP film for detection of caffeic acid has been ...
Wang Yunwei - - 2013
Highly-qualified graphene was prepared by the ultrasonic exfoliation of commercial expanded graphite (EG) under the promotion of (NH4)2CO3 decomposition. The yield of graphene from the first exfoliation is 7 wt%, and it can be increased to more than 65 wt% by repeated exfoliations. Atomic force microscopy, x-ray photoelectron spectroscopy and Raman analysis ...
Cao Zheng - - 2013
Amylose brushes were synthesized by enzymatic polymerization with glucose-1-phosphate as monomer and Rabbit Muscle Phosphorylase b as catalyst on gold-covered surfaces of a quartz crystal microbalance. Fourier Transform Infrared (FT-IR) spectra confirmed the presence of the characteristic absorption peaks of amylose between 3100 cm-1 and 3500 cm-1. The thickness of ...
Yadav Kapil D KD Junior Resident, Department of Rasa Shastra, Faculty of Ayurveda, IMS, BHU, Varanasi, Uttar Pradesh, - - 2013
Brahmi Ghrita was processed as per the process of Snehapaka procedure described in classics. It contained Brahmi (Bacopa monneri), Vacha (Acorus calamus), Kushtha (Sassurea lappa), Shankhapushpi (Convolvulos pluricalis), and Purana Ghrita. In the preparation of Brahmi Ghrita, Brahmi Swarasa, Kalka Dravya of Brahmi, Vacha, Kushtha, and Shankhapushpi were mixed in ...
Sugnaux Caroline - - 2013
This manuscript has studied the surface immobilization of five organic acid modified atom transfer radical polymerization (ATRP) initiators based on salicylic acid, catechol, phthalic acid and m- and p-benzoic acid on alumina and has investigated the growth of hydrophilic poly(2-hydroxyethyl methacrylate) (PHEMA) and poly(poly(ethylene glycol)methycrylate) (PPEGMA6) brushes from the resulting ...
Prasad Bhim Bali - - 2013
The present work is related to combination of molecularly imprinted solid-phase microextraction and complementary molecularly imprinted polymer-sensor. The molecularly imprinted polymer grafted on titanium dioxide modified silica fiber was used for microextraction, while the same polymer immobilized on multiwalled carbon nanotubes/titanium dioxide modified pencil graphite electrode served as a detection ...
Zhu Ting F - - 2013
Here we describe a method for preparing fatty acid micelles. The method for adding micelles to a buffered solution containing fatty acid or phospholipid vesicles is also discussed.
Munirathinam Rajesh R Laboratory of Molecular Nanofabrication, MESA+ Institute for Nanotechnology, University of Twente, P.O. Box 217, 7500 AE Enschede, The - - 2013
Polystyrene sulfonate polymer brushes, grown on the interior of the microchannels in a microreactor, have been used for the anchoring of gallium as a Lewis acid catalyst. Initially, gallium-containing polymer brushes were grown on a flat silicon oxide surface and were characterized by FTIR, ellipsometry, and X-ray photoelectron spectroscopy (XPS). ...
Sekar M Gomathi - - 2012
Microscopists opine that acid-alcohol decolourized slides may enhance acid-fast bacilli (AFB) smear positivity, and published documents on equivalence of acid and acid-alcohol in ZN staining method are not easily accessible. National Institute for Research in Tuberculosis, Chennai, India. To document the equivalence of 25% sulphuric acid (ZN-acid method) and 3% ...
Anagaw Belay - - 2012
Direct sputum smear microscopy remains the most widespread method for the diagnosis and followup of patients with tuberculosis despite its limited sensitivity. Our aim was to investigate whether sputum smears prepared using liquefaction with household bleach and concentration by centrifugation was more sensitive for the detection and quantification of acid-fast ...
Yip Kai-Tai - - 2012
The Brønsted aids: The first dehydrogenative arylation of β-keto esters with arenes under ambient aerobic conditions was described. Under a Pd(II) /Brønsted acid co-catalytic system, regioselective arylations with alkoxylated arenes and phenols were achieved in good yields, even in gram-scale conditions.
Jakab Gergely - - 2012
Bordwell's method of overlapping indicators was used to determine the pK(a) values of some of the most popular (thio)urea organocatalysts via UV spectrophotometric titrations. The incremental effect of CF(3) groups on acidic strength was also investigated. The pK(a)'s are in the range of 8.5-19.6. The results may lead to a ...
Cao Jie - - 2012
Accumulation of saturated fatty acids in the liver can cause nonalcoholic fatty liver disease (NAFLD). This study investigated saturated fatty acid induction of endoplasmic reticulum (ER) stress and apoptosis in human liver cells and the underlying causal mechanism. Human liver L02 and HepG2 cell lines were exposed to the saturated ...
Fedor Dawn M - - 2012
Abstract Background: Concomitant supplementation with docosahexaenoic acid (22:6 n-3; DHA) prevented trans-10, cis-12-conjugated linoleic acid (CLA)-induced nonalcoholic fatty liver disease (NAFLD) and insulin resistance. The effective dose of DHA and mechanisms involved are poorly understood. Methods: We examined the ability of DHA (0.5% and 1.5%) to prevent increases in NAFLD ...
Jørgensen Marianne Hørby - - 2012
BACKGROUND:: Patients with cystic fibrosis (CF) have low levels of n-3 long chain polyunsaturated fatty acids (n-3 LCPUFA) in plasma or red blood cells (RBC), as also seen in other chronic and acute liver diseases. The differences may be more pronounced in cystic fibrosis transmembrane conductance regulator protein (CFTR) regulated ...
Arduini Alessandro - - 2012
Cholestatic liver diseases are characterized by blockade of bile flow from the liver to the intestine, and accumulation of hydrophobic bile acids in the liver and plasma. As a consequence an inflammatory response evolves associated with increased apoptosis, oxidative stress, and eventually fibrosis. Cholestasis is associated with profound metabolic changes, ...
Moya Marta - - 2012
Triglyceride accumulation in nonalcoholic fatty liver (NAFL) results from unbalanced lipid metabolism which, in the liver, is controlled by several transcription factors. The Foxa subfamily of winged helix/forkhead box (Fox) transcription factors comprises three members which play important roles in controlling both metabolism and homeostasis through the regulation of multiple ...
Zhang Yong - - 2012
Hepatic inflammation and degeneration induced by lipid depositions may be the major cause of nonalcoholic fatty liver disease. In this study, we tried to investigate the effects of saturated and unsaturated fatty acids on hepatoma cell apoptosis. H4IIE liver cells were treated with palmitic acid, linoleic acid, or both with ...
Watanabe Chika - - 2012
Glucagon is believed to be one of the most important peptides for upregulating blood glucose levels. However, homozygous glucagon-green fluorescent protein (gfp) knock-in mice (Gcg(gfp/gfp): GCGKO) are normoglycemic despite the absence of proglucagon-derived peptides, including glucagon. To characterize metabolism in the GCGKO mice, we analyzed gene expression and metabolome in ...
Shimada Tsutomu - - 2011
Flavangenol, one of several pine bark extract products, is expected to prevent metabolic diseases with its potent antioxidant effect, its anti-obesity effect and its improvement of insulin sensitivity. In this study, targeting the liver as one of the organs that plays an important role in energy metabolism, Flavangenol was investigated ...
Petit J M - - 2011
BACKGROUND & AIMS: Non-alcoholic fatty liver disease (NAFLD) is commonly associated with obesity, metabolic syndrome and type 2 diabetes. Although dietary fat contributes substantially to the accumulation of liver fat, the role of individual fatty acids in this accumulation is unclear. OBJECTIVE: In this study, we set out to determine ...
Luís Paula B M - - 2011
BACKGROUND: Valproic acid (VPA) is a widely used anticonvulsant drug which affects mitochondrial metabolism including the catabolism of fatty acids and branched-chain amino acids. AIMS: To elucidate the effect of valproate on the leucine pathway through a targeted metabolomics approach and the evaluation of the effects of valproate on the ...
Bui Peter P Molecular Toxicology Program, University of California, Los Angeles, California 90095, - - 2012
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) adversely affects many mammalian organs and tissues. These effects are mediated by the aryl hydrocarbon receptor (AHR). CYP1A1, CYP1A2 and CYP1B1 are upregulated by the liganded AHR. These (and other) cytochromes P450 can metabolize arachidonic acid into a variety of bioactive eicosanoids. Towards investigating a potential role of ...
Høstmark Arne T - - 2011
Previously, cheese intake was shown to be inversely related to serum triglycerides, raising the possibility that cheese might inhibit triglyceride synthesis, which is governed by fatty acid desaturases. Therefore, analyses were done to study whether cheese intake was associated with indexes that reflect fatty acid desaturation in 121 healthy ethnic ...
Abhilash P A - - 2011
Abstract Both oxidative stress and endotoxins mediated immunological reactions play a major role in the progression of alcoholic hepatic fibrosis. Ascorbic acid has been reported to reduce alcohol induced toxicity and ascorbic acid levels are reduced in alcoholics. Hence we investigated the hepatoprotective action of ascorbic acid in the reversal ...
Fuchs Michael - - 2012
Non-alcoholic fatty liver disease (NAFLD) is currently evolving as the most common liver disease worldwide. It may progress to liver cirrhosis and liver cancer and is poised to represent the most common indication for liver transplantation in the near future. The pathogenesis of NAFLD is multifactorial and not fully understood, ...
Mackay Dylan S - - 2011
Intrauterine growth restriction (IUGR), in both animals and humans, has been linked to metabolic syndrome later in life. There has been recent evidence that perturbations in sulfur amino acid metabolism may be involved in this early programming phenomenon. Methionine is the precursor for cellular methylation reactions and for the synthesis ...
Wadhwani Nisha S - - 2011
A disturbed fatty acid metabolism increases the risk of adult non-communicable diseases. This study examines the effect of maternal micronutrients on the fatty acid composition, desaturase activity, mRNA levels of fatty acid desaturases and transport proteins in the liver. Pregnant female rats were divided into 6 groups at 2 levels ...
Doolaege Evelyne H A - - 2011
The oxidative stability of liver pâté was investigated in relation to different doses of rosemary extract (RE) and sodium nitrite. Colour stability, lipid oxidation (TBARS) and concentrations of ascorbic acid, α-tocopherol, carnosic acid and nitrite were measured on the batters before cooking and on the cooked liver pâté before and ...
Cécile Martel - - 2011
Non-alcoholic fatty liver disease (NAFLD) is the most common liver pathology characterized by fat accumulation in a context of metabolic syndrome or insulin resistance. It can be associated with obesity, diabetes, hyperinsulinemia, dyslipidemia as well as hypertension. NAFLD consists of a large spectrum of hepatic lesions including benign steatosis, non-alcoholic ...
Craig Sandra S Department of Chemistry and Center for Biotechnology and Drug Design, Georgia State University, Atlanta, GA 30302-4098, USA. - - 2012
Carbohydrates in various forms play a vital role in numerous critical biological processes. The detection of such saccharides can give insight into the progression of such diseases such as cancer. Boronic acids react with 1,2 and 1,3 diols of saccharides in non-aqueous or basic aqueous media. Herein, we describe the ...
Chong Catherine P K - - 2011
Born at 27 weeks gestation, a child of consanguineous parents of Pakistani origin required prolonged parenteral nutrition. She developed jaundice, with extensive fibrosis and architectural distortion at liver biopsy; jaundice resolved with supportive care. Serum γ-glutamyl transpeptidase values were within normal ranges. The bile acids in her plasma and urine were ...
Novak Elizabeth M - - 2012
The n-3 fatty acids contribute to regulation of hepatic fatty acid oxidation and synthesis in adults and accumulate in fetal and infant liver in variable amounts depending on the maternal diet fat composition. Using 2D gel proteomics and matrix-assisted laser desorption/ionization time of flight mass spectrometry, we recently identified altered ...
Jain Ajay Kumar AK Section of Pediatric Gastroenterology, Hepatology, and Nutrition, Baylor College of Medicine, Houston, Texas 77030, - - 2012
Total parenteral nutrition (TPN) is essential for patients with impaired gut function but leads to parenteral nutrition-associated liver disease (PNALD). TPN disrupts the normal enterohepatic circulation of bile acids, and we hypothesized that it would decrease intestinal expression of the newly described metabolic hormone fibroblast growth factor-19 (FGF19) and also ...
Das Undurti N - - 2011
Non-alcoholic fatty liver disease (NAFLD) is a low-grade systemic inflammatory condition, since liver and adipose tissue tumor necrosis factor-α (TNF-α) and TNF receptor 1 transcripts and serum TNF-α levels are increased and IL-6(-/-) mice are less prone to NAFLD. Fatty liver damage caused by high-fat diets is associated with the ...
Park Han-Sol HS Asan Institute for Life Sciences, University of Ulsan College of Medicine, Seoul 138-736, - - 2011
Methionine and choline-deficient diet (MCD)-induced fatty liver is one of the best-studied animal models of fatty liver disease. The present study was performed to clarify the relative contributions of individual lipid metabolic pathways to the pathogenesis of MCD-induced fatty liver. Hepatic lipogenesis mediated by the sterol regulatory element-binding protein (SREBP-1c) ...
Hassan Ammar Ali - - 2011
Objectives. To acquire new knowledge on the nutritional composition of semi-domesticated reindeer (Rangifer t. tarandus L.) and their nutritional value for humans. The results could be useful in updating the Norwegian Food Composition Database, whose current data on reindeer is limited. Study design. Cross-sectional study on population of semi-domesticated reindeer ...
Kunde Sachin S - - 2011
Fructose-sweetened liquid consumption is associated with fatty liver and oxidative stress. In rodent models of fructose-mediated fatty liver, protein consumption is decreased. Additionally, decreased sulfur amino acid intake is known to cause oxidative stress. Studies were designed to test whether oxidative stress in fructose-sweetened liquid-induced fatty liver is caused by ...
Xu Ziwei - - 2011
BACKGROUND & AIMS: Parenteral nutrition-associated liver disease (PNALD) complicates the treatment of patients with short bowel syndrome (SBS). Some studies have shown omega-3 polyunsaturated fatty acids (ω-3 PUFAs) have favorable effects in treating PNALD in children. We, therefore, investigate the effects of ω-3 PUFAs supplemented intravenous lipid emulsion (ILE) on ...
Fordahl Steve S Department of Nutrition, University of North Carolina at Greensboro, Greensboro, NC 27402-6170, - - 2012
Overexposure to waterborne manganese (Mn) is linked with cognitive impairment in children and neurochemical abnormalities in other experimental models. In order to characterize the threshold between Mn-exposure and altered neurochemistry, it is important to identify biomarkers that positively correspond with brain Mn-accumulation. The objective of this study was to identify ...
Valenzuela Rodrigo - - 2011
Non-alcoholic fatty liver disease (NAFLD) is the most important cause of chronic liver disease that is characterized by hepatocyte triacylglycerol accumulation (steatosis), which can progress to inflammation, fibrosis, and cirrhosis (steatohepatitis). Overnutrition triggers the onset of oxidative stress in the liver due to higher availability and oxidation of fatty acids ...
Powell David A - - 2011
An in vitro screening protocol was used to transform a systemically-distributed SCD inhibitor into a liver-targeted compound. Incorporation of a key nicotinic acid moiety enables molecular recognition by OATP transporters, as demonstrated by uptake studies in transfected cell lines, and likely serves as a critical component of the observed liver-targeted ...
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