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Hettenhausen Christian - - 2014
BackgroundHerbivory induces the activation of mitogen-activated protein kinases (MAPKs), the accumulation of jasmonates and defensive metabolites in damaged leaves and in distal undamaged leaves. Previous studies mainly focused on individual responses and a limited number of systemic leaves, and more research is needed for a better understanding of how different ...
Eldridge Kris - - 2014
The enthalpy and entropy changes for the formation of the 1:1 complexes of methanol with various gaseous protonated amino acids have been measured using pulsed-ionization high pressure mass spectrometry. The enthalpy changes for formation of the clusters, Gly(MeOH)H+, Ala(MeOH)H+, Val(MeOH)H+, Leu(MeOH)H+, Ile(MeOH)H+ and Pro(MeOH)H+ have been determined to be -92.0, ...
Noponen Virpi V University of Jyväskylä, Department of Chemistry, P.O. Box 35, FI-40014 University of Jyväskylä, Finland. Electronic address: - - 2014
The synthesis and gelation properties of a picolinic acid conjugated bile acid derivative in the presence of metal salts along with the stimuli-responsiveness of the systems are reported. The gels are formed in the presence of Cu(2+) ions in the solvent systems composed of 30-50% of organic solvent (MeOH, acetonitrile, ...
Kim Hee-Yong HY Laboratory of Molecular Signaling, DICBR, NIAAA, NIH, Bethesda, MD - - 2014
Docosahexaenoic acid (DHA, 22:6 n-3) is an omega-3 polyunsaturated fatty acid highly enriched in the brain and is recognized as an essential nutrient for proper development of brain function. Common brain injuries often cause lifelong neurological and cognitive impairments, especially in learning and memory. Optimizing the nutritional DHA status in ...
Cal Marta M Faculty of Chemistry, University of Wrocław, Joliot-Curie 14, 50-383, Wrocław, - - 2014
Electrospray ionization mass spectrometry (MS) has been widely used to detect noncovalent interactions in supramolecular compounds, especially in biological systems. In our work, we present the application of the electrospray ionization MS technique to characterize the metallamacrocycles, known as metallacrowns. This project involves investigations of the aminohydroxamic acids structure and ...
Ren Chuan-Li CL Beijing National Laboratory for Molecular Sciences (BNLMS), CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China. - - 2014
An efficient cooperative biscinchona alkaloid and Lewis acid catalytic system was developed in the enantioselective α-alkylation of 2-oxindoles with (3-indolyl)(phenyl)methanols to provide (2-oxindole)-linker-indole derivatives in good yields (70-83%) with high enantioselectivities (81%-92%).
Dawidowicz Andrzej L - - 2014
Chlorogenic acid (CQA), ester of caffeic with quinic acid, is a natural compound found in a wide array of plants. Although coffee beans are most frequently mentioned as plant products remarkably rich in CQAs, their significant amounts can also be found in many berries, e.g. blueberries. The paper shows and ...
Pu Qiang-Hong QH Institute of Life Science, Chongqing Medical University , Chongqing , P. R. - - 2014
Abstract 1. Gallic acid is a main polyphenol in various fruits and plants. Inhibitory characteristics of gallic acid on CYP3A4 were still unclear. The objective of this work is hence to investigate inhibitory characteristics of gallic acid on CYP3A4 using testosterone as the probe substrate in human liver microsomes (HLMs) and ...
Kalpio Marika M Food Chemistry and Food Development, Department of Biochemistry, University of Turku, FI-20014 Turku, - - 2015
Enantiomers of racemic triacylglycerol (TAG) mixtures were separated using two chiral HPLC columns with a sample recycling system and a UV detector. A closed system without sample derivatisation enabled separation and identification by using enantiopure reference compounds of eleven racemic TAGs with C12-C22 fatty acids with 0-2 double bonds. The ...
Liu Ge G FOODplus Research Centre, School of Agriculture, Food and Wine, University of Adelaide, Adelaide, South Australia, - - 2014
Conventional assays of omega-3 long chain polyunsaturated fatty acid (n-3 LCPUFA) status in humans involve venous blood collection and expensive, multi-step processes that limit their usefulness as screening tools. This study aimed to develop a capillary dried blood spot (DBS) system capable of protecting n-3 LCPUFA from oxidation for up ...
Shen Yue Y Beijing Key Laboratory of Lignocellulosic Chemistry, College of Materials Science and Technology, Beijing Forestry University, Beijing 100083, PR - - 2014
InCl3, a water-compatible Lewis acid, was used for the conversion of microcrystalline cellulose to produce 5-hydroxymethylfurfural (HMF) in a H2O/THF biphasic system. Addition of NaCl increased the HMF yield significantly but suppressed the levulinic acid (LA) formation. The HMF yield of 39.7% was obtained in 2h at 200°C in the ...
Rodríguez-Álvarez María J MJ Laboratorio de Compuestos Organometálicos y Catálisis (Unidad Asociada al CSIC), Departamento de Química Orgánica e Inorgánica, (IUQOEM), Centro de Innovación en Química Avanzada (ORFEO-CINQA), Facultad de Química, Universidad de Oviedo, E-33071 Oviedo, Spain. - - 2014
Cycloisomerisation of γ-alkynoic acids into cyclic enol-lactones was conveniently performed, for the first time, in the eutectic mixture 1ChCl/2Urea under standard bench experimental conditions (at room temperature, under air and in the absence of co-catalysts) by using a new iminophosphorane-Au(i) complex as the catalyst. Furthermore, the catalytic system could be ...
Murai Kenichi K Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamada-oka, Suita, Osaka 565-0871, Japan. murai@phs.osaka-u.ac.jp - - 2014
An enantioselective iodolactonization reaction of allenoic acids has been developed using a trisimidazoline catalyst and I2. Our mechanistic study suggests the involvement of a π-allyl cation intermediate in this reaction system.
Tomoo Toshiyuki - - 2014
This paper describes the design, synthesis, and biological evaluation of new indole-based cytosolic phospholipase A2α (cPLA2α, a group IVA phospholipase A2) inhibitors. A screening-hit compound from our library, (E)-3-{4-[(4-chlorophenyl)thio]-3-nitrophenyl}acrylic acid (5), was used to design a class of 3-(1-aryl-1H-indol-5-yl)propanoic acids as new small molecule inhibitors. The resultant structure-activity relationships studied ...
Ramalingam Prakash P College of Pharmacy, Gachon University, 191 Hambakmoero, Yeonsu-gu, Incheon, 406-799, South - - 2014
Solid lipid nanoparticles (SLNs) have been proposed as a colloidal carrier system that could enhance the oral bioavailability of curcumin. However, a burst release of the loaded drug, which occurs in acidic environments, has been a main obstacle to the oral delivery of curcumin by using SLNs as a carrier ...
Watanabe Naoko N Department of Biomolecular Science, Faculty of Science, Toho University, 2-2-1 Miyama, Funabashi, Chiba, 274-8510, Japan, - - 2014
Polyunsaturated fatty acids have been attracting considerable interest because of their many biological activities and important roles in human health and nutrition. Dihomo-γ-linolenic acid (DGLA; C20: 3n-6) is known to have an anti-inflammatory activity, but its range of effects was not well studied because of its limited natural sources. Taking ...
Cross Keith J KJ Oral Health CRC, Melbourne Dental School, Bio21 Institute, The University of Melbourne, 720 Swanston Street, Melbourne, Victoria, 3010, - - 2014
Some amino acids are more energetically costly to synthesise de novo, therefore many microbes have evolved to regulate the metabolic expenditure of the cell and reduce the energy burden of extracellular unrecyclable proteins. Several oral bacterial species take up amino acids and peptides obtained from proteolysis of host proteins and ...
Liu Haiyan H National Aquafeed Safety Assessment Station, Feed Research Institute, Chinese Academy of Agricultural Sciences, Beijing, China; College of Life Science, Hebei Normal University, Shijiazhuang, - - 2014
This study determined the deposition and depletion in rainbow trout after continuous administration of melamine (MEL) alone or a blend of MEL and cyanuric acid (CYA). The plasma, muscles, kidneys, liver and gills were sampled at 0, 3, 7, 13, 21, 28 and 42d. After the final sampling at 42d, ...
Baldasquin-Caceres B B Department of Pathology and Anatomical Sciences, Faculty of Medicine and Dentistry, Ageing Research Institute, University of Murcia, Murcia, - - 2014
To evaluate the chemopreventive potential of phenolic compounds - potassium apigenin, cocoa, catechins, eriocitrin and rosmarinic acid in oral carcinogenesis induced in hamsters by means of the topical application of 7,12-dimethylbenz(a)anthracene(DMBA). An experimental study at the University of Murcia. 50 male Syrian hamsters (Mesocricetus auratus) were divided into five groups ...
Shi Yun Y College of Science, Beijing Key Laboratory of Environmentally Harmful Chemical Analysis, Beijing University of Chemical Technology, Beijing 100029, PR - - 2014
Enzyme mimetics have recently attracted considerable interest because of their high stability and low cost. We developed a general H2O2-involved fluorescence system using Fe3O4 magnetic microspheres as peroxidase mimetics and benzoic acid (BA) as indicator. Glucose and p-nitrophenol were used as models to determine the characteristics and effectiveness of the ...
Sullivan J S JS Section of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Digestive Health Institute, Children's Hospital Colorado, University of Colorado School of Medicine, Aurora, CO, - - 2014
Fructose intake is associated with non-alcoholic fatty liver disease (NAFLD) development. The objective of this study was to measure fructose absorption/metabolism in paediatric NAFLD compared with obese and lean controls. Children with histologically proven NAFLD, and obese and lean controls received oral fructose (1 g kg(-1) ideal body weight). Serum glucose, insulin, ...
Running Cordelia A CA Purdue - - 2014
Fatty acids that vary in chain length and degree of unsaturation have different effects on metabolism and human health. As evidence for a "taste" of non-esterified fatty acids (NEFA) accumulates, it may be hypothesized that fatty acid structures will also influence oral sensations. This study examined oral sensitivity to caproic ...
Koetting Michael C MC McKetta Department of Chemical Engineering, The University of Texas at Austin, C0400, Austin, TX 78712, United States. Electronic address: - - 2014
pH-Responsive hydrogels comprised of itaconic acid copolymerized with N-vinylpyrrolidone (P(IA-co-NVP)) were synthesized and tested as carriers for the oral delivery of high isoelectric point (pI) exhibiting therapeutic proteins. Swelling studies show that P(IA-co-NVP) hydrogels exhibit significantly greater and faster pH-responsive swelling than previously studied methacrylic acid-based hydrogels, achieving up to ...
Cao Yang Y Institute of Environmental Medicine, Karolinska Institutet, Stockholm, - - 2014
In the present review we provide an update of the appropriate use of chelating agents in the treatment of intoxications with compounds of mercury, lead and copper. The relatively new chelators meso-2,3-dimercaptosuccinic acid (DMSA) and 2,3-dimercapto-propanesulphonate (DMPS) can effectively mobilize deposits of mercury as well as of lead into the ...
Wang Hui H School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 110016, - - 2014
Huo Luo Xiao Ling Dan (HLXLD), a Chinese herbal formula composed of 11 different herbs, has been used traditionally for the treatment of arthritis and other chronic inflammatory diseases. However, the pharmacokinetic profile of its anti-inflammatory bioactive compounds has not been elucidated. Boswellic acids are the bioactive compounds with potent ...
Cai Qingqing Q Department of Pharmacy, Huashan Hospital, Fudan University , Shanghai , P.R. China - - 2014
Abstract The present study examined the effects of lipid vehicle and intestinally based efflux processes on intestinal lymphatic transport of paclitaxel (PTX) in the mesenteric lymph duct-cannulated anesthetized rat model. PTX solution alone, PTX solution pretreated with the P-glycoprotein (P-gp) inhibitor verapamil and/or PTX and a 2:1 (w/w) mixture of ...
Keast Russell Sj RS Centre for Physical Activity and Nutrition Research, School of Exercise and Nutrition Sciences, Deakin University, Burwood, Victoria, Australia. Electronic address: - - 2014
Excessive consumption of dietary fat is implicated with development of obesity. Impaired oral and gastrointestinal chemoreception to the breakdown products of dietary fat, fatty acids, may be associated with increased energy consumption. The objective of this study was to determine if impaired oral fatty acid chemoreception influences energy intake and ...
Zacchigna Marina M Department of Chemical and Pharmaceutical Sciences, University of Trieste, Piazzale Europa 1, 34127 Trieste, - - 2014
A highly water-soluble macromolecular compound of ursolic acid with monomethoxypoly(ethylene glycol) (mPEG) was prepared. The physicochemical properties and stabilities under different conditions were investigated. By PEG conjugation, greatly increased water solubility was obtained, and the results showed that this conjugate was a potential prodrug for the oral delivery of ursolic ...
Pettit Marie W MW Faculty of Engineering and Science, University of Greenwich, Central Avenue, Chatham Maritime, Kent ME4 4TB, - - 2014
An increasing human population requires a secure food supply and a cost effective, oral vaccine delivery system for livestock would help facilitate this end. Recombinant antigen adsorbed onto silica beads and coated with myristic acid, was released (∼15% (w/v)) over 24h at pH 8.8. At pH 2, the myristic acid ...
Tang Yan-Bo YB Beijing Key Laboratory of Active Substance Discovery & Druggability Evaluation, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, 1 Xiannongtan Street, Beijing 100050 - - 2014
Protein tyrosine phosphatase 1B (PTP1B) is a promising therapeutic target for type 2 diabetes. Herein, we report the evolution of a previously identified 3-phenylpropanoic acid-based PTP1B inhibitor to an orally active lead compound. A series of 3-phenylpropanoic acid-based PTP1B inhibitors were synthesized, and three of them, 3-(4-(9H-carbazol-9-yl)phenyl)-5-(3,5-di-tert-butyl-4-methoxyphenyl)-5-oxopentanoic acid (9), 3-(4-(9H-carbazol-9-yl)phenyl)-5-(4'-bromo-[1,1'-biphenyl]-4-yl)-5-oxopentanoic acid (10) ...
Morabito Rossana R Department of Human and Social Sciences, Via T. Cannizzaro 278, Messina, Italy. Electronic address: - - 2014
Nematocyst discharge and concomitant delivery of toxins is triggered to perform both defence and predation strategies in Cnidarians, and may lead to serious local and systemic reactions in humans. Pelagia noctiluca (Cnidaria, Scyphozoa) is a jellyfish particularly abundant in the Strait of Messina (Italy). After accidental contact with this jellyfish, ...
de Ferrars R M RM Department of Nutrition, Norwich Medical School, University of East Anglia, Norwich, NR4 7TJ, United - - 2014
Anthocyanins are phytochemicals with reported vasoactive bioactivity. However, given their instability at neutral pH, they are presumed to undergo significant degradation and subsequent biotransformation. The aim of the present study was to establish the pharmacokinetics of the metabolites of cyanidin-3-glucoside (C3G), a widely consumed dietary phytochemical with potential cardio-protective properties. ...
Nøhr Martha Kampp MK Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2100 Copenhagen, - - 2014
The anti-epileptic drug substance vigabatrin is used against infantile spasms. In vitro evidence suggests that vigabatrin is transported via the proton coupled amino acid transporter (PAT1). The aim of the present study was to investigate whether the intestinal absorption of vigabatrin in vivo was mediated via PAT1 in non-rodents. This ...
Joshi Santosh S Korean Lichen Research Institute, Sunchon National University, Suncheon 540-950, - - 2014
Graphis upretii is a new lichen species discovered in Vietnam. The species is characterized by a loosely corticate, rough, whitish grey to greyish green thallus, elongate and irregularly branched lirellae with an apically thin complete thalline margin (negrosina morph), laterally carbonized, entire proper exciple, clear hymenium, hyaline, 16~20 transversely locular ...
Stine Cynthia B CB Center for Veterinary Medicine, US Food and Drug Administration, 8401 Muirkirk Rd, Laurel, MD 20708, USA. Electronic address: - - 2014
The industrial chemical melamine was used in 2007 and 2008 to raise the apparent protein content in pet feed and watered down milk, respectively. Because humans may be exposed to melamine via several different routes into the human diet as well as deliberate contamination, this study was designed to characterize ...
Pitt William C WC Hawaii Field Station, National Wildlife Research Center, Wildlife Services, Animal and Plant Health Inspection Service, U.S. Department of Agriculture, P.O. Box 10880, Hilo, HI, 96721, USA, - - 2014
We examined potential exposure of Hawaiian hoary bats (Lasiurus cinereus semotus) to citric acid, a minimum risk pesticide registered for control of invasive Eleutherodactylus frog populations. Hoary bats are nocturnal insectivores that roost solitarily in foliage, federally listed as endangered, and are endemic to Hawaii. Oral ingestion during grooming of ...
Chevrot Michael M From Physiologie de la Nutrition et Toxicologie (MC, PP-D, DA, AB, MG, and PB) and Physiopathologie des Dyslipidémies (IR and BV), Unité Mixte de Recherche (UMR) U866, Institut National de la Santé et de Recherche Médicale (INSERM), Université de Bourgogne/AgroSup Dijon, Dijon, France; the Centre National de la Recherche Scientifique, UMR6265 (GE, MG, SI, and SN) and the Institut National de la Recherche Agronomique, UMR1324 Centre des Sciences du Goût et de l'Alimentation, Dijon, France (GE, MG, SI, and SN); and the Université de Bourgogne, UMR Centre des Sciences du Goût et de l'Alimentation, Dijon, France (GE, MG, SI, and - - 2014
The association between the orosensory detection of lipids, preference for fatty foods, and body mass index (BMI; in kg/m(2)) is controversial in humans. We explored the oral lipid-sensing system and the orosensory-induced autonomic reflex system in lean and obese subjects. Lean (BMI: 19 to <25; n = 30) and obese ...
Yu Xiaolan X Department of Biological Sciences, School of Dental Medicine, Case Western Reserve University, Cleveland, Ohio, - - 2014
Periodontal pathogens such as Porphyromonas gingivalis and Fusobacterium nucleatum produce five different short-chain fatty acids (SCFAs) as metabolic by-products. We detect significantly higher levels of SCFAs in the saliva of patients with severe periodontal disease. The different SCFAs stimulate lytic gene expression of Kaposi's sarcoma-associated herpesvirus (KSHV) dose dependently and ...
Yun Dae-Woong DW Oral Biology Research Institute, Chosun University School of Dentistry, - - 2014
Compared to most normal cells that express L-type amino acid transporter 2, L-type amino acid transporter 1 is highly expressed in cancer cells and presumed to support their elevated growth and proliferation. This study examined JPH203, a potent and selective L-type amino acid transporter 1 inhibitor, and its ability to ...
Fazio Alejandra T - - 2014
A strain of the lichen mycobiont of Ramalina celastri, isolated from ascospores, was cultured axenically on two solid media containing high amounts of the carbon source: sucrose in MY10 and mannitol in BMRM. Usnic acid, the major cortical lichen metabolite, was produced by the colonies grown on MY10, with a ...
Khatun Zehedina Z Department of Green Bioengineering, Korea National University of Transportation, Chungju, 380-702 Republic of - - 2014
Oral delivery is the preferred route to deliver therapeutics via nanoparticles due to ease of administration and patient acceptance. Here, we report on the findings of the absorption pathway of taurocholic acid (TCA)-linked heparin and docetaxel (DTX) conjugate, which we refer to as HDTA. We studied the oral absorption of ...
Zhou Wei W College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210046, PR China; Jiangsu Engineering Research Center for Efficient Delivery System of TCM, PR China; Nanjing Engineering Research Center for Industrialization of Chinese Medicine Pellets, PR - - 2014
The current study aims to investigate the pharmacokinetic study of eight caffeic acid derivatives (forsythoside A, isoforsythoside, forsythoside B, neochlorogenic acid, chlorogenic acid, cryptochlorogenic acid, 3,5-dicaffeoylquinic acid and 3,4-dicaffeoylquinic acid) following oral administration of Flos Lonicerae-Fructus Forsythiae herb combination in rats. A rapid and sensitive ultra performance liquid chromatography-tandem mass ...
Chagas Pietro Maria PM Laboratório de Síntese, Reatividade e Avaliação Farmacológica e Toxicológica de Organocalcogênios, Universidade Federal de Santa Maria, CEP 97105-900, Santa Maria, RS, - - 2014
The present study evaluated the antinociceptive and anti-inflammatory effects of per oral (p.o.) administration of salicylic acid-derivative organoselenium compounds in chemical models of nociception in mice. The compounds (50mg/kg; p.o.) were administered 30 and 60min before the nociceptive behaviour and compared to the positive-control, acetylsalicylic acid (ASA; 200mg/kg; p.o.). In ...
Gama Ricardo Ribeiro RR Postgraduate Programme in Oncology, Universidade de São Paulo, São Paulo, SP, Brazil and Operative Technique and Experimental Surgery Laboratory, Faculdade Evangélica do Paraná, Alameda Augusto Stelfeld, 2134 Curitiba, PR 80730-150, - - 2014
To study the potential chemopreventive effects of polyunsaturated fatty acids omega-3 in Swiss mice submitted to oral and oesophageal carcinogenesis induction by 4-nitroquinoline-1-oxide (4-NQO). The animals underwent carcinogenesis induction with 50 µg/mL 4-NQO for eight weeks. The animals were divided into groups: Group I-4-NQO induction without chemoprevention, Group II-chemoprevention with ...
Schmitt Juliano J Department of Dermatology, Botucatu Medical School, Sao Paulo State University, Botucatu, SP, - - 2014
Objective: To investigate the influence of a regular oral use of acetylsalicylic acid in the prevalence of actinic keratosis. Methods: A case-control study with dermatologic outpatients above 50 years of age assessed between 2009 and 2011. Cases were defined as those who had been under regular use of oral acetylsalicylic ...
Yoneda Saori S Department of Oral Medical Science, Ohu University, Fukushima, - - 2014
Fusobacterium nucleatum is a ubiquitous member of the human oral flora and is associated with the development of periodontitis and a variety of other types of polymicrobial infections of the mucosa. In the oral cavity, this species is one of the few that is prevalent in both healthy and diseased ...
Hellwig Elmar E Department of Operative Dentistry and Periodontology, Center of Dental Medicine, University of Freiburg, Freiburg, - - 2014
Acidic or EDTA-containing oral hygiene products and acidic medicines have the potential to soften dental hard tissues. The low pH of oral care products increases the chemical stability of some fluoride compounds and favours the incorporation of fluoride ions in the lattice of hydroxyapatite and the precipitation of calcium fluoride ...
López-Madrigal Sergio S Institut Cavanilles de Biodiversitat i Biologia Evolutiva, Universitat de Valencia Valencia, - - 2014
Intracellular bacterial supply of essential amino acids is common among sap-feeding insects, thus complementing the scarcity of nitrogenous compounds in plant phloem. This is also the role of the two mealybug endosymbiotic systems whose genomes have been sequenced. In the nested endosymbiotic system from Planococcus citri (Pseudococcinae), "Candidatus Tremblaya princeps" ...
Ross Brian M BM Division of Medical Sciences, Northern Ontario School of Medicine, Lakehead University, 955 Oliver Road, Thunder Bay, Ontario P7B5E1, Canada. - - 2014
Ethane in human breath derives from lipid peroxidation, specifically the reaction between omega-3 fatty acids and reactive oxygen species. It has been proposed to be a non-invasive marker of oxidative stress, a deleterious process which may play an important role in the pathophysiology of several common diseases. It is unclear, ...
Haryono Rivkeh Y RY School of Exercise and Nutrition Sciences, Deakin - - 2014
Emerging evidence from a number of laboratories indicates that humans have the ability to identify fatty acids in the oral cavity, presumably via fatty acid receptors housed on taste cells. Previous research has shown that an individual's oral sensitivity to fatty acid, specifically oleic acid (C18:1) is associated with body ...
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