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Stanstrup Jan - - 2014
Whey protein has been demonstrated to improve fasting lipid and insulin response in overweight and obese individuals. To establish new hypotheses for this effect and to investigate the impact of stomach emptying we compared plasma profiles after intake of whey isolate (WI), casein, gluten (GLU) and cod (COD). Obese, non-diabetic ...
Hill T L TL The Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, - - 2014
Tramadol is a centrally acting analgesic that is often used in conjunction with nonsteroidal anti-inflammatory drugs (NSAIDs). The effect of coadministration of tramadol and indomethacin on gastric barrier function in dogs is unknown. That coadministration of a nonselective NSAID (indomethacin) and tramadol would decrease recovery of barrier function as compared ...
Cook Michael T MT School of Pharmacy, University of Reading, Reading, RG6 6AD, United - - 2014
Probiotic bacteria have gained popularity as a defence against disorders of the bowel. However, the acid sensitivity of these cells results in a loss of viability during gastric passage and, consequently, a loss of efficacy. Probiotic treatment can be supplemented using 'prebiotics', which are carbohydrates fermented specifically by probiotic cells ...
Valenzuela Manuel M Faculty of Medicine, Department of Molecular and Cellular Biology, Laboratory of Molecular Microbiology, ICBM, University of Chile, Santiago, Chile; Toxicology and Cancer Biology Research Group, Louvain Drug Research Institute, Université Catholique de Louvain, Bruxelles, - - 2014
Helicobacter pylori is a motile microaerophilic bacterium that colonizes the human stomach. H. pylori infection triggers gastric diseases, such as gastritis, peptic ulcer and gastric cancer. Stomach represents a barrier for microorganism colonization, particularly because of its high hydrochloric acid concentration. The main mechanism developed by H. pylori to maintain intracellular ...
Sakarya Serhan S Department of Infectious Diseases and Clinical Microbiology, School of Medicine, Adnan Menderes University, - - 2014
Helicobacter pylori is a major causative agent of gastritis and peptic ulcer disease and is an established risk factor for gastric malignancy. Antibiotic combination therapy can eradicate H. pylori. As these same regimens can evoke adverse effects and resistance, new alternative therapies or adjunctive treatments are needed. A probiotic approach may ...
Alai Milind M Graduate Institute of Pharmaceutical Sciences, School of Pharmacy, National Taiwan University, F 12 NO. 1 Jen Ai Rd. Sec. 1, Taipei, 100, - - 2014
The objective of this study is to combine nanoparticle design and enteric coating technique to sustain the delivery of an acid-labile drug, lansoprazole (LPZ), in the treatment of acid reflux disorders. Lansoprazole-loaded Eudragit® RS100 nanoparticles (ERSNP-LPZ) as well as poly(lactic-co-glycolic acid) (PLGA) nanoparticles (PLGANP-LPZ) were prepared using a solvent evaporation/extraction ...
Rubach Malte M German Research Center for Food Chemistry, Freising, Germany; Department of Food Science, University of Wisconsin, Madison, WI, - - 2014
Coffee consumption sometimes is associated with symptoms of stomach discomfort. This work aimed to elucidate whether two coffee beverages, containing similar amounts of caffeine, but differing in their concentrations of (β) N-alkanoyl-5-hydroxytryptamides (C5HTs), chlorogenic acids (CGAs), trigonelline, and N-methylpyridinium (N-MP) have different effects on gastric acid secretion in healthy volunteers. ...
Fazzari Marco M Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America ; Fondazione Ri.MED, Palermo, - - 2014
Extra virgin olive oil (EVOO) and olives, key sources of unsaturated fatty acids in the Mediterranean diet, provide health benefits to humans. Nitric oxide (•NO) and nitrite (NO2 (-))-dependent reactions of unsaturated fatty acids yield electrophilic nitroalkene derivatives (NO2-FA) that manifest salutary pleiotropic cell signaling responses in mammals. Herein, the ...
Berté Priscila Elisabeth PE Programa de Pós-Graduação em Ciências Farmacêuticas e Núcleo de Investigações Químico-Farmacêuticas (NIQFAR), Universidade do Vale do Itajaí - UNIVALI, Rua Uruguai, 458, 88302-202, Itajaí, SC, - - 2014
Previous phytochemical studies carried out with Rubus imperialis Chum. Schl. (Rosaceae) have demonstrated the presence of triterpenes (niga-ichigoside F1 and 2β,3β,19α-trihydroxyursolic acid) in this species. The literature indicates that triterpenes are closely related to some pharmacological activities, including antiulcer activity. Therefore, in view of the previous promising results with this ...
Jan Muhammad M Department of Pharmacology, College of Medicine, University of Dammam, Dammam, Saudi - - 2014
Objective: To determine the efficacy of extract of Ammi visnaga on volume and acidity of stimulated gastric secretion in rabbits and also its safety on liver and kidney function. Study Design: Quasi experimental study. Place and Duration of Study: Pharmacology Department, Saidu Medical College, Swat, in the years 2008-9. Methodology: ...
Shinkai Hirohiko H Division of Gastroenterology, Tohoku University Graduate School of - - 2014
Gastric acid measurement is useful in assessing the effectiveness of antisecretory drugs, however, the conventional tests involve invasive nasogastric intubation. Orally administered (13)C-labeled calcium carbonate (Ca(13)CO3) reacts with gastric acid to produce (13)C-labeled carbon dioxide ((13)CO2), which is then excreted in the breath. The objective of this study was to ...
Mard Seyyed Ali SA Research Institute for Infectious Diseases of Digestive System, Physiology Research Center (PRC) and Department of Physiology, The School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz 61357 15794, - - 2014
The present study was designed to investigate the effect of H2S on distention-induced gastric acid secretion. Fifty-two rats were randomly assigned to seven experimental groups. The gastric acid secretion was stimulated by gastric distention. Two groups of rats received L-cysteine or saline for 5 days before stimulation of the gastric ...
Iijima Katsunori K Division of Gastroenterology, Tohoku University Graduate School of - - 2014
Measurement of the gastric acid secretion is useful for estimating the risk for various diseases in the upper gastro-intestinal tract; however, the procedure causes significant distress to the subjects. Pepsinogens I and II are secreted from the gastric fundic glands, and thus, the serum pepsinogen levels reflect the gastric functional ...
O'Connor Anthony A Trinity College, University of Dublin, Dublin, - - 2014
The core function of the human stomach is as an aid to digestion. The four key components of gastric digestive function are its function as a reservoir, acid secretion, enzyme secretion and its role in gastrointestinal motility. The reservoir capacity of the stomach allows it to increase its volume significantly ...
Cunningham R R Microbiology Department, Plymouth Hospitals NHS Trust, Plymouth, UK. Electronic address: - - 2013
Proton pump inhibitor (PPI) use increases the risk of Clostridium difficile infection (CDI) despite C. difficile spores being acid resistant. Swallowed saliva contains nitrite which reacts with gastric acid, producing bactericidal nitrogen oxides. With 5mM nitrite at pH 2 (reflecting normal gastric conditions) all C. difficile spores were killed within 15min. No ...
Nakao Ken-Ichiro K Department of Legal Medicine, School of Medicine, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan. Electronic address: - - 2014
Oral ingestion of concentrated acetic acid causes corrosive injury of the gastrointestinal tract. To assess the effects of a low concentration of acetic acid on gastric mucosa, we examined the gastric mucosal changes in rats at 1 and 3 days after the injection of 5% or 25% acetic acid into ...
Okamoto Takeshi T Yamaguchi University, Graduate School of Medicine, Minamikogushi 1-1-1, Ube, Yamaguchi 755-8505, - - 2013
In the stomach of a gastric ulcer patient who had been administered an anti-acid, a gram-negative and urease-negative bacillus similar in size to Helicobacter pylori was infected together with H. pylori. According to biochemical test and 16S rRNA gene analysis, the urease-negative bacterium was identified as Kingella denitrificans, a human nasopharyngeal ...
Pasham Venkanna V Department of Physiology, University of Tübingen, Tübingen, - - 2013
Background/Aims: Glucocorticoids enhance gastric acid secretion and inhibit gastric cyclooxygenase, thus downregulating formation of PGE2, an inhibitor of gastric acid secretion. In erythrocytes, PGE2 formation is inhibited by annexin 7. The present study thus explored whether annexin 7 participates in the regulation of gastric acid secretion. Methods: Annexin 7 protein ...
Chu Shijian - - 2013
The review summarizes the past year's literature, basic science and clinical, regarding the neural, paracrine, hormonal, and intracellular regulation of gastric acid secretion. Gastric acid facilitates the digestion of protein as well as the absorption of iron, calcium, vitamin B12, and certain medications (e.g. thyroxin). It also kills ingested microorganisms ...
Dikici Abdullah - - 2013
This study investigated the survival and acid tolerance of Listeria monocytogenes during the 2-day processing stage and 90-day ripening of Savak tulum cheese, a traditional cheese in Turkey. Experimental Savak tulum cheese was produced from raw sheep's milk that was inoculated with a L. monocytogenes mixture consisting of five strains ...
Fashner Julia - - 2013
More than 11 million individuals receive proton pump inhibitor (PPI) prescriptions each year in the United States. Although PPIs are effective treatment for peptic ulcers and esophagitis and provide symptom relief for many other conditions, their use carries risks. They decrease gastric acid and can lower blood levels of drugs ...
Tang Jihui - - 2013
Poly(amino acid)s are well-known as biodegradable and environmentally acceptable materials. In this study, a series of poly(L-aspartic acid)-b-poly(L- phenylalanine) (PAA-PPA) compounds with different degrees of polymerization were used to prepare copolymer micelles for a poorly water-soluble drug 4-amino-2-trifluoromethyl-phenyl retinate (ATPR, a novel all-trans retinoic acid derivative) and in vivo pharmacokinetics, ...
Fiorica Calogero - - 2013
Atom Transfer Radical Polymerization (ATRP) has been successfully employed to obtain a new derivative of hyaluronic acid (HA) able to change its solubility as a function of external pH and then to be potentially useful for intestinal release of bioactive molecules, included enzymes and proteins. In particular, a macroinitiator has ...
Trechot Philippe - - 2013
Nicorandil, a nicotinamide ester, was first reported to be involved in the induction of oral ulcers in 1997. Since then, many reports of single or multiple nicorandil-induced ulcerations (NIUs) have been reported. We hypothesised that in the case of high-dosage nicorandil or after an increased dosage of nicorandil, nicotinic acid ...
Marcus Elizabeth A - - 2013
Gastric infection by H. pylori is the most common cause of ulcer disease and gastric cancer. The mechanism of progression from gastritis and inflammation to, in a fraction of those infected, ulcers and cancer, is not definitively known. Significant acidity is unique to the gastric environment and is required for ...
Kun Lin - - 2013
Proton pump inhibitors (PPIs) are widely used for the treatment of acid-related upper digestive diseases, including gastric and duodenal ulcer and gastroesophageal reflux disease (GERD). Remarkably, several small clinical trials have shown that these drugs also reduce the symptoms and frequency of atrial fibrillation (AF) episodes in patients treated for ...
Fotaki Nikoletta - - 2013
Proton pump inhibitors are potent gastric acid-suppressing agents and belong to the most widely sold drugs in the world. However, even though these antisecretory agents are regarded as safe, they can show several interactions with co-administered drugs. Due to the suppression of gastric acid secretion, the can significantly alter the ...
Zolotarev Vasiliy A - - 2013
In the stomach, pre-absorptive perception of food constituents is of particular importance in maintaining secretion and motility that matches the quantity and quality of nutrients. Products of food protein hydrolysis, free amino acids and short peptides, are the most potent chemical stimulants of the gastric phase of digestion. They are ...
Kristinova Vera - - 2013
This study evaluates whether marine lipids can oxidise in acidic stomach environment and whether authentic gastric juice has the potential to act as a pro- or anti-oxidative medium. Oxidation of herring lipids in emulsions and liposomes was followed in in vitro digestion models containing authentic human gastric juice, and compared ...
Baek Jong-Suep - - 2013
Zaltoprofen is a non-steroidal anti-inflammatory drug (NSAID) belonging to the propionic acid class. It has strong inhibitory effects on acute and chronic inflammation. Although zaltoprofen is well tolerated orally compared to other NSAIDs, it has to be administered in three to four doses per day and was associated with ulcerogenicity, ...
Li Lin - - 2013
Folium Turpiniae has been used as a traditional Chinese medicine for the treatment of abscesses, fevers, gastric ulcers, and inflammations. This paper describes a strategy of combining HPLC with photodiode array detection and quadrupole TOF-MS, as well as phytochemical and chemometrics analysis for the characterization, isolation, and simultaneous quantification of ...
Lee Yeong Yeh YY Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, - - 2013
The gastroesophageal junction is structurally complex and functionally designed to ensure the acid secreted by the most proximal gastric mucosa flows towards the stomach and not up onto the oesophageal squamous mucosa. The pattern and mechanism of reflux vary with the severity of reflux disease and this probably represents different ...
Sharma Anamika - - 2013
Amino acids are known to possess variable efficacy against ulceration. Considering the good antiulcer activity of amino acids, a series of urea/thiourea derivatives of glutamic acid conjugated benzisothiazole analogue 3a-u with various substituents on aryl ring were synthesized, spectroscopically characterized and evaluated for in vitro H(+)/K(+)-ATPase inhibition. Majority of the ...
Oiso Shigeru - - 2013
Ghrelin, a gastric hormone, is a growth hormone-releasing peptide. Its serine-3 acylation with octanoic acid is essential for its orexigenic activity, and therefore, inhibition of the acylation of ghrelin may help in decreasing appetite and preventing obesity. This study aimed to establish a human gastric cell-based assay system to evaluate ...
Rosa Natalia N - - 2013
The relationship between the aleurone cell integrity and the exposure or release of bioavailable ferulic acid (FA) with the antioxidant capacity of aleurone in in vitro and under simulated gastric conditions was explored. The antioxidant capacity of aleurone was increased by around 2-fold when its median particle size was reduced ...
Areche Carlos - - 2013
The chemical study of a dichloromethane extract from Azorella compacta was directed to the isolation of characteristic mulinane and azorellane diterpenoids in order to determine their gastroprotective activity. Usual chromatographic techniques on the extract led to the isolation of 12 compounds, which were identified by their spectroscopic properties. The HCl/ethanol-induced ...
Le Maux Solène - - 2013
The dairy protein β-lactoglobulin (BLG) is known to bind fatty acids such as the salt of the essential long-chain fatty acid linoleic acid (cis, cis-9,12-octadecadienoic acid, n-6, 18:2). The aim of the current study was to investigate how bovine BLG-linoleate complexes, of various stoichiometry, affect the enzymatic digestion of BLG ...
Dai Jinfeng - - 2013
Polyunsaturated fatty acids (PUFAs) have tumoricidal action, though the exact mechanism of their action is not clear. The results of the present study showed that of all the fatty acids tested, linoleic acid (LA) and alpha-linolenic acid (ALA) were the most effective in suppressing the growth of normal gastric cells ...
Weinstein D H - - 2013
BACKGROUND: Gastro-oesophageal reflux disease (GERD) and gastric acid hypersecretion respond well to suppression of gastric acid secretion. However, clinical management and research in diseases of acid secretion have been hindered by the lack of a non-invasive, accurate and reproducible tool to measure gastric acid output (GAO). Thus, symptoms or, in ...
Abdelwahab Siddig Ibrahim - - 2013
Some phytochemicals demonstrate gastroprotective effects by inhibiting gastric acid secretion or through antioxidant action. One of these antioxidant phytochemicals which have been studied is gallic acid. However, its mechanism in the treatment and prevention of gastric ulcer remains unclear. This study evaluated the anti-ulcerogenic mechanism(s) of gallic acid (GA) and ...
Vanuytsel T - - 2013
BACKGROUND: Duodenal acid exposure induces a duodenogastric reflex resulting in gastric relaxation, inhibition of antral motility, and sensitization of the proximal stomach to distension. Duodenal hypersensitivity to acid has been identified as a potential pathogenic mechanism in functional dyspepsia. The nature and localization of the duodenal acid-sensitive receptors are still ...
Zhu S - - 2013
Cronobacter is associated with outbreaks of rare, but life-threatening cases of meningitis, necrotizing enterocolitis, and sepsis in newborns. This study was conducted to determine the effect of organic acids on growth of Cronobacter in laboratory medium and reconstituted powdered infant formula (PIF) as well as the bacteriostatic effect of slightly ...
Wakim Shoukri A - - 2013
This study was conducted to evaluate gastric acid secretion in acute renal failure, highlighting the roles of renal mass and gastrin hormone. Acute uremic rats were divided into bilateral nephrectomized and bilateral ureteric obstruction groups. Gastric juice was collected for 2 h and analyzed for volume, free acidity, total acidity, ...
Cheng Changyong - - 2013
The foodborne pathogen Listeria monocytogenes is able to colonize the human and animal intestinal tracts and subsequently crosses the intestinal barrier, causing systemic infection. For successful establishment of infection, L. monocytogenes must survive and adapt to low pH environment of the stomach. Sequence analysis indicates that lmo0043, an orthologue of ...
Kyaw Win Thiri - - 2013
Some patients with Parkinson disease improved their symptoms on treatment with nicotine patch or gum. Nicotine has also been studied for its antidyskinetic effect on levodopa-induced dyskinesia. We determined the effects of nicotine on levodopa pharmacokinetics and gastric emptying in healthy subjects and on levodopa transport in Caco-2 monolayers in ...
Sen S - - 2013
In the present study, we investigate the antiulcerogenic effect of gallic acid against aspirin plus pyrolus ligation-induced gastric ulcer in rats. Rats were treated with gallic acid (100 and 200 mg/kg) and famotidine (20 mg/kg) for 1 week, followed by induction of gastric ulcer using the aspirin plus pyrolus ligation ...
Mingrone Geltrude G Department of Internal Medicine, Catholic University of Rome, Rome, Italy. - - 2013
Even-number, medium-chain dicarboxylic acids (DAs), naturally occurring in higher plants, are a promising alternative energy substrate. Unlike the homologous fatty acids, DAs are soluble in water as salts. They are β-oxidized, providing acetyl-CoA and succinyl-CoA, the latter being an intermediate of the tricarboxylic acid cycle. Sebacic acid and dodecanedioic acid, ...
Mishra Vaibhav - - 2013
In continuation of our drug discovery program on Indian medicinal plants, the gastro protective mechanism of chebulinic acid isolated from Terminalia chebula fruit was investigated. Chebulinic acid was evaluated against cold restraint (CRU), aspirin (AS), alcohol (AL) and pyloric ligation (PL) induced gastric ulcer models in rats. Potential anti-ulcer activity ...
Zullo Angelo - - 2013
Gastroesophageal reflux disease (GORD) is highly prevalent in the general population. In the last decade, a potential relationship between Helicobacter pylori (H. pylori) eradication and GORD onset has been claimed. The main putative mechanism is the gastric acid hypersecretion that develops after bacterial cure in those patients with corpus-predominant gastritis. ...
Kelly David G - - 2013
Eighteen dry dog foods obtained commercially in the United States were digested using microwaveassisted nitric acid digestion and a simulated gastric digestion. Digests were analysed for 23 elements using inductively coupled plasma - mass spectrometry. Data, expressed as dry matter concentrations, were compared to published nitric acid digestion results. Nitric ...
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