Search Results
Results 1 - 50 of 1553
1 2 3 4 5 6 7 8 9 10 >
Nirma Charlotte C CNRS-Institut de Chimie des Substances Naturelles , 1 Avenue de la Terrasse, 91198 Gif-sur-Yvette Cedex, - - 2014
Ilicicolinic acids A, C, and D (1-3) and ilicicolinal (4) were isolated from a fungus isolated from a Nasutitermes corniger nest in French Guiana. The structures of ilicicolinic acids C and D and ilicicolinal were elucidated using 1D and 2D NMR spectroscopic data as well as MS data. Ilicicolinic acids ...
Saichana Natsaran N Centre of the Region Haná for Biotechnological and Agricultural Research, Faculty of Science, Palacký University, Šlechtitelů 11, 783 71 Olomouc, Czech Republic. Electronic address: - - 2014
Acetic acid bacteria are gram-negative obligate aerobic bacteria assigned to the family Acetobacteraceae of Alphaproteobacteria. They are members of the genera Acetobacter, Gluconobacter, Gluconacetobacter, Acidomonas, Asaia, Kozakia, Swaminathania, Saccharibacter, Neoasaia, Granulibacter, Tanticharoenia, Ameyamaea, Neokomagataea, and Komagataeibacter. Many strains of Acetobacter and Komagataeibacter have been known to possess high acetic acid ...
Shan Guo-Qiang - - 2014
The classic Lossen rearrangement is a well-known reaction describing the transformation of an O-activated hydroxamic acid into the corresponding isocyanate. In this study, we found that chlorinated benzoquinones (CnBQ) serve as a new class of agents for the activation of benzohydroxamic acid (BHA), leading to Lossen rearrangement. Compared to the ...
Irwansyah I I School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore, 639798, - - 2014
Antimicrobial hydrogels are prepared based on the co-assembly of commercial Fmoc-phenylalanine and Fmoc-leucine, which act as the hydrogelator and antimicrobial building block, respectively. This co-assembled antimicrobial hydrogel is demonstrated to exhibit selective bactericidal activity for gram-positive bacteria while being biocompatible with normal mammalian cells, showing great potential as an antimicrobial ...
Hao Xin X Department of Applied Chemistry, Beijing Institute of Technology , Beijing , - - 2014
Abstract A novel series of (1,2-benzothiazin-4-yl)acetic acid enantiomers was prepared by chiral resolution, and their absolute configurations were determined using the PGME method. The biological evaluation of the racemate and single enantiomers has shown a remarkable difference for the aldose reductase inhibitory activity and selectivity. The (R)-(-)-enantiomer exhibited the strongest ...
Anokwuru Chinedu P CP a Department of Basic Science , School of Science and Technology, Babcock University , Ilisan Remo , - - 2014
This study was aimed at characterising the secondary metabolites responsible for antibacterial and antioxidant activities of Acalypha wilkesiana. Purification of the defatted methanol leaves extract was guided by the DPPH free radical scavenging assay as well as by evaluation of the antibacterial activity against four bacterial strains. As a result, ...
Bianchi Federico F Laboratory of Atmospheric Chemistry, Paul Scherrer Institute , Villigen 5232, - - 2014
We investigated the nucleation of sulfuric acid together with two bases (ammonia and dimethylamine), at the CLOUD chamber at CERN. The chemical composition of positive, negative, and neutral clusters was studied using three Atmospheric Pressure interface-Time Of Flight (APi-TOF) mass spectrometers: two were operated in positive and negative mode to ...
Diercks Hannah H Institute of Molecular Physiology and Biotechnology of Plants (IMBIO), University of Bonn, 53113 Bonn, - - 2014
Glycolipids are mainly found in photosynthetic organisms (plants, algae, cyanobacteria), Gram-positive bacteria and a few other bacterial phyla. They serve as membrane lipids and play a role under phosphate deprivation as surrogate for phospholipids. Mesorhizobium loti accumulates different di- and triglycosyl diacylglycerols synthesized by the processive glycosyltansferase Pgt-Ml, and two ...
Rew Yosup - - 2014
Structure-based rational design and extensive SAR led to the discovery of AMG 232 (1), a potent piperidinone inhibitor of MDM2-p53 association, which is currently being evaluated in human clinical trials for the treatment of cancer. Further modifications of 1, including replacing the carboxylic acid with an 4-amidobenzoic acid, afforded AM-7209 ...
Komaniecka Iwona I Maria Curie-Sklodowska University in Lublin, Poland; - - 2014
The chemical structures of the unusual hopanoid-containing lipids A of the lipopolysaccharides (LPS) from three strains of Bradyrhizobium (slow-growing rhizobia) have been established. They differed considerably from other Gram-negative bacteria in regards to the backbone structure, the number of ester-linked long chain hydroxylated fatty acids as well as the presence ...
Morjan Rami Y RY Chemistry Department, Faculty of Science, Islamic University of Gaza, PO Box 108, Gaza Strip, - - 2014
Synthesis of a series of novel N-acylhydrazones of nicotinic acid hydrazides 3a-j via condensation of nicotinic acid hydrazide 1 with the corresponding aldehydes and ketones is described. The series 3a-j was evaluated for in vitro antibacterial activity against two gram negative (Pseudomonas aeruginosa and Klebsiella pneumoniae) and two gram positive ...
Grainger Rachel R School of Biological and Chemical Sciences, Queen Mary University of London, Joseph Priestley Building, Mile End Road, E1 4NS, London - - 2014
A combined experimental and computational investigation on the Ag-catalysed decarboxylation of benzoic acids is reported herein. The present study demonstrates that a substituent at the ortho position exerts dual effects in the decarboxylation event. On one hand, ortho-substituted benzoic acids are inherently destabilised starting materials compared to their meta- and ...
Carrillo W W Instituto de Investigación en Ciencias de la Alimentación (CIAL), CSIC-UAM, Nicolás Cabrera 9, Spain; Campus de Cantoblanco, 28049 Madrid, Spain, Facultad de Ciencia e Ingeniería en Alimentos, Universidad Técnica de Ambato Campus Huachi, Avenida Los Chasquis y Rio Payamino, Ambato, - - 2014
The antimicrobial activity of heat-denatured and hydrolyzed hen egg white lysozyme against oenological lactic acid and acetic acid bacteria was investigated. The lysozyme was denatured by heating, and native and heat-denatured lysozymes were hydrolyzed by pepsin. The lytic activity against Micrococcus lysodeikticus of heat-denatured lysozyme decreased with the temperature of ...
Pande Ranjana R Agricultural and Food Engineering Department, Indian Institute of Technology, Kharagpur 721302, India. Electronic address: - - 2015
The feasibility of measuring phytic acid content in green gram (Vigna radiata) seeds was investigated by Fourier Transform Near-Infrared (FT-NIR) spectroscopic technique. Pure phytic acid standards of varying concentrations were scanned using FTNIR spectroscopy. The spectra were measured in diffused reflectance mode by keeping 100-1500mg/100g standard of pure phytic acid ...
Leandro Luís Fernando LF University of - - 2014
Antibiotic-resistant bacteria have emerged from the widespread use of antibiotics worldwide and have prompted the search for new sources of antimicrobial substances. Pinus species contain several bioactive compounds consisting mainly of terpenes, terpenoids, and some other aromatic and aliphatic constituents. These compounds exert important biological effects, and pine oils have ...
Liu Yu Y College of Science, Hunan Agriculture University, Changsha, Hunan 410128, - - 2014
An acid-free lead rechargeable battery system comprising PbSO4 as the negative electrode, LiMn2O4 as the positive electrode and a neutral Li2SO4 aqueous solution as electrolyte is reported and its electrochemical performance is very good. It shows great promise to reduce the global use of lead by 50% since it is ...
Wang Caixia C Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, No. 16, Nanxiaojie, Dongzhimennei, Beijing 100700, China; National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, - - 2014
In this study, pinewood and corn stover pretreated with the ionic liquid (IL) 1-allyl-3-methylimidazolium chloride (AmimCl) were used as a feedstock for succinic acid production. Results reveal that 5% (v/v) AmimCl inhibited bacterial growth, whereas 0.01% (v/v) AmimCl inhibited succinic acid production. AmimCl was effective in extracting cellulose from pinewood ...
Kampf Günter G Günter Kampf, Patricia M Fliss, Bode Science Center, Bode Chemie GmbH, 22525 Hamburg, - - 2014
The bioburden (blood, protein, pathogens and biofilm) on flexible endoscopes after use is often high and its removal is essential to allow effective disinfection, especially in the case of peracetic acid-based disinfectants, which are easily inactivated by organic material. Cleaning processes using conventional cleaners remove a variable but often sufficient ...
Ma Baiquan B Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture, Wuhan Botanical Garden of the Chinese Academy of Sciences, Wuhan 430074, PR China; Graduate University of Chinese Academy of Sciences, 19A Yuquanlu, Beijing 100049, PR - - 2015
Soluble sugar and malic acid contents in mature fruits of 364 apple accessions were quantified using high-performance liquid chromatography (HPLC). Fructose and sucrose represented the major components of soluble sugars in cultivated fruits, whilst fructose and glucose were the major items of sugars in wild fruits. Wild fruits were significantly ...
Petrović Jovana J Institute for biological research "Siniša Stanković", University of Belgrade, Bulevar Despota Stefana 142, 11000 Belgrade, Serbia. - - 2014
Laetiporus sulphureus is an edible wood-rooting basidiomycete. The nutritional and medicinal properties of this mushroom have long been known by traditional practitioners. The aim of this study was to determine the proximate composition, total phenol antioxidant capacity and antimicrobial activities of different extracts of L. sulphureus. Different extraction methodologies, including ...
Jaiswal Rakesh R School of Engineering and Science, Chemistry, Jacobs University Bremen, Campus Ring 1, 28759 Bremen, Germany. Electronic address: - - 2014
The chlorogenic acids, chlorogenic acid glycosides and flavonoids of the leaves of Lonicera henryi L. (Caprifoliaceae) were investigated qualitatively by liquid chromatography tandem mass spectrometry. Thirty-one chlorogenic acids and their glycosides were detected and characterized to their regioisomeric level on the basis of their unique fragmentation pattern in the negative ...
Sethiya Neeraj Kumar NK Pharmacy Department, Faculty of Technology and Engineering, Kalabhavan, The M. S. University of Baroda, Vadodara, Gujarat 390002, India - - 2014
In this study, we investigated a new, simple, sensitive, selective and precise high-performance thin-layer chromatography (HPTLC) fingerprint and quantitative estimation method for the analysis of ursolic acid, betulinic acid, stigmasterol and lupeol in Shankhpushpi botanicals. Linear ascending development was carried out in a twin trough glass chamber saturated with petroleum ...
Souto José A JA School of Chemistry, University of Nottingham, Nottingham, NG7 2RD, UK. - - 2014
The thermolysis of S-aryl sulfinimines is shown to generate 1,2-disulfoxides and disulfides via initial Cope elimination, dimerisation of the produced sulfenic acid to a thiosulfinate, and subsequent disproportionation of the thiosulfinate.
Hiraiwa Yukiko Y Pharmaceutical Research Center, Meiji Seika Pharma, Co., Ltd, 760 Morooka-cho, Kohoku-ku, Yokohama 222-8567, Japan. Electronic address: - - 2014
3-(4-Hydroxypiperidine-1-yl) phthalic acid 1 shows potent inhibitory activity against metallo-β-lactamase, which is known to inactivate β-lactam antibiotics such as carbapenems. Here, the structure of co-crystals of the metallo-β-lactamase IMP-1 and 1 was first analyzed by X-ray crystallography, and then used for structure-based drug design. Four novel compounds bearing substituents at ...
Yin Wei W School of Pharmacy, Shanghai Key Laboratory of New Drug Design, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, P. R. - - 2015
Iminodiacetic acid (IDA) is dicarboxylic acid amine, which may produce stronger interaction with polar or charged compounds than bidentate α,β-amino acid. In this article, a novel type of tridentate zwitterionic HILIC stationary phase was prepared by covalently bonding N-benzyl IDA on silica gel via copper(I) catalyzed Huisgen azide-alkyne 1,3-dipolar cycloaddition ...
Zhang Lingjuan L Department of chemistry, Renmin University of China, Beijing, 100872, China. xulj@chem.ruc.edu.cn - - 2014
A general and efficient Rh(i)-catalyzed decarbonylative direct C2-olefination of indoles with vinyl carboxylic acids has been developed. The reaction exhibits excellent functional group tolerance, regioselectivity and stereoselectivity, giving a broad range of C2-alkenylated indoles in good to excellent yields.
Nishanth Kumar S KS a Division of Crop Protection/Division of Crop Utilization, Central Tuber Crops Research Institute , Sreekariyam, Thiruvananthapuram , 695017 , - - 2014
The aim of this study was to investigate the antimicrobial property of the compounds present in the lichen Usnea albopunctata. Ethyl acetate extract of the lichen was purified by column chromatography to yield a major compound which was characterised by spectroscopic methods as protocetraric acid. In this study, protocetraric acid ...
González Miguel A MA Departamento de Química Orgánica, Universidad de Valencia , Dr. Moliner 50, 46100 Burjassot, Valencia, - - 2014
The semisynthesis of the antiviral abietane diterpenoid (+)-jiadifenoic acid C starting from the available methyl ester of callitrisic acid (4-epidehydroabietic acid) isolated from sandarac resin is reported. A protocol for the isolation of methyl callitrisate (methyl 4-epidehydroabietate) in gram quantities from sandarac resin is also described. Allylic C-17 oxygenation was ...
Rosen Rachel R Aerodigestive Center, Department of Gastroenterology, Boston Children's Hospital, Boston, - - 2014
The use of acid suppression has been associated with an increased risk of upper and lower respiratory tract infections in the outpatient setting but the mechanism behind this increased risk is unknown. We hypothesize that this infection risk results from gastric bacterial overgrowth with subsequent seeding of the lungs. To ...
Kuml Decha - - 2014
A new spiculisporic acid derivative, spiculisporic acid E (2), and a new natural product 3-acetyl ergosterol 5, 8-endoperoxide (1), were isolated, together with ergosta-4, 6, 8 (14), 22-tetraen-3-one, glaucanic acid and glauconic acid, from the culture of the marine-sponge associated fungus Talaromyces trachyspermus (KUFA 0021). All the compounds were inactive ...
Yu Fei F Department of Traditional Chinese Medicine, Shengjing Hospital of China Medical University, Shenyang, 110004, Liaoning, - - 2014
Multidrug resistance (MDR) is a challenging issue in the treatment of gastric cancer. Pseudolaric acid B is a new diterpene acid compound isolated from pseudolarix, which has been found to have anti-tumor activities in recent studies. The purpose of the present study was to evaluate the effects of pseudolaric acid ...
Kovačič Nataša Nagelj NN Faculty of Pharmacy, University of Ljubljana, Aškerčeva cesta 7, 1000 Ljubljana, Slovenia. Electronic address: - - 2014
The aim of the present study was to show that the physiological variability of fasted gastric pH and tablet gastric retention time contributes to the overall variability of simulated plasma profiles of diclofenac. Those two parameters were implemented into dissolution study and plasma profiles were simulated under assumptions that in ...
Song Weiguo W Department of Medicinal Chemistry, School of Pharmacy, Shandong University, Ji'nan, Shandong, R.P. China; Shouguang Fukang Pharmaceutical Co., Ltd., Shouguang, Shandong, R.P. - - 2014
Acid-related diseases of the upper gastrointestinal tract, especially gastroesophageal reflux disease (GERD), remain a wide spread problem worldwide. In this paper, we reported the design, synthesis and preliminary gastric antisecretory activity evaluation of novel pyrimidine derivatives as acid pump antagonists. The gastric antisecretory activity assay results showed that all compounds ...
Khan Ruqaiyah R Department of Pharmacology, Siddhartha Institute of Pharmacy, Dehradun, Uttarakhand, - - 2014
Rabeprazole, a member of substituted benzimidazoles, inhibits the final step in gastric acid secretions. This drug claims to cause fastest acid separation (due to higher pKa), and more rapidly converts to the active species to aid gastric mucin synthesis. The most significant pharmacological action of Rabeprazole is dose dependent suppression ...
Oku Naoya N a Biotechnology Research Center and Department of Biotechnology , Toyama Prefectural University , Toyama , - - 2014
The cyanobacterium Nostoc verrucosum occurs in cool, clear streams and its gelatinous colonies, called "ashitsuki," have been eaten in ancient Japan. Its ethanolic extract was found to inhibit the growth of Gram-positive bacteria and activity-guided fractionation yielded an unusual n-1 fatty acid, (9Z,12Z)-9,12,15-hexadecatrienoic acid (1), as one of the active ...
Miller Erica F EF Microbiology Department, The University of Georgia, Athens, - - 2014
The gastric pathogen Helicobacter pylori possesses a highly active urease to support acid tolerance. Urea hydrolysis occurs inside the cytoplasm resulting in the production of NH3 that is immediately protonated to form NH4 (+). This ammonium must be metabolized or effluxed because its presence within the cell is counterproductive to ...
Blackler Rory W RW Department of Medicine, McMaster University, Hamilton, Ontario, - - 2014
Nonsteroidal anti-inflammatory drugs (NSAIDs) remain among the most commonly used medications because of their effectiveness in reducing pain and inflammation. Inhibitors of gastric acid secretion can substantially reduce the damaging effects of NSAIDs in the stomach and duodenum. However, there are no proven effective preventative or curative treatments for NSAID-induced ...
Pyar Hassan - - 2014
Abstract In the present study, a capsule formulation composed of enteric coated granules of Lactobacillus acidophilus ATCC 4962 was developed using Eudragit L30D-55 as enteric polymer. Optimization of the capsule formulation was achieved with a maximum viable cell count after 2 h of incubation in acid medium and disintegration time ...
Oyarzúa Alarcón Pía P Laboratorio de Biopelículas y Microbiología Ambiental, Centro de Biotecnología, Universidad de Concepción, PO Box 160-C, Concepción, - - 2014
Magnesium is an element essential for life and is found ubiquitously in all organisms. The different cations play important roles as enzymatic co-factors, as signaling molecules, and in stabilizing cellular components. It is not surprising that magnesium salts in microbiological experiments are typically associated with positive effects. In this study ...
Asokkumar K K Department of Pharmacology, College of Pharmacy, Sri Ramakrishna Institute of Paramedical Sciences, Coimbatore, Tamil Nadu, - - 2014
Antioxidant supplements with existing drugs may confer better therapeutic efficacy in oxidative stress related diseases. The purpose of the present work was to characterize the interaction and investigate the protective effect of H2 blocker famotidine and gallic acid in combination against experimentally induced peptic ulcer. Preventive effect of gallic acid ...
Stanstrup Jan - - 2014
Whey protein has been demonstrated to improve fasting lipid and insulin response in overweight and obese individuals. To establish new hypotheses for this effect and to investigate the impact of stomach emptying we compared plasma profiles after intake of whey isolate (WI), casein, gluten (GLU) and cod (COD). Obese, non-diabetic ...
Hill T L TL The Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, - - 2014
Tramadol is a centrally acting analgesic that is often used in conjunction with nonsteroidal anti-inflammatory drugs (NSAIDs). The effect of coadministration of tramadol and indomethacin on gastric barrier function in dogs is unknown. That coadministration of a nonselective NSAID (indomethacin) and tramadol would decrease recovery of barrier function as compared ...
Cook Michael T MT School of Pharmacy, University of Reading, Reading, RG6 6AD, United - - 2014
Probiotic bacteria have gained popularity as a defence against disorders of the bowel. However, the acid sensitivity of these cells results in a loss of viability during gastric passage and, consequently, a loss of efficacy. Probiotic treatment can be supplemented using 'prebiotics', which are carbohydrates fermented specifically by probiotic cells ...
Valenzuela Manuel M Faculty of Medicine, Department of Molecular and Cellular Biology, Laboratory of Molecular Microbiology, ICBM, University of Chile, Santiago, Chile; Toxicology and Cancer Biology Research Group, Louvain Drug Research Institute, Université Catholique de Louvain, Bruxelles, - - 2014
Helicobacter pylori is a motile microaerophilic bacterium that colonizes the human stomach. H. pylori infection triggers gastric diseases, such as gastritis, peptic ulcer and gastric cancer. Stomach represents a barrier for microorganism colonization, particularly because of its high hydrochloric acid concentration. The main mechanism developed by H. pylori to maintain intracellular ...
Sakarya Serhan S Department of Infectious Diseases and Clinical Microbiology, School of Medicine, Adnan Menderes University, - - 2014
Helicobacter pylori is a major causative agent of gastritis and peptic ulcer disease and is an established risk factor for gastric malignancy. Antibiotic combination therapy can eradicate H. pylori. As these same regimens can evoke adverse effects and resistance, new alternative therapies or adjunctive treatments are needed. A probiotic approach may ...
Keshavarzi Zakieh Z Department of Physiology , School of Medicine, Bojnurd University of Medical Sciences, Bojnurd , I. R. - - 2014
Gut-brain axis (GBA) is very important in creation and modulation of gastrointestinal problems. Aloe vera gel has gastroprotective properties. The purpose of this study was to evaluate the effect of aqueous extract of Aloe vera leaves on the gastric acid secretion and brain and intestinal water content following acetic acid ...
Alai Milind M Graduate Institute of Pharmaceutical Sciences, School of Pharmacy, National Taiwan University, F 12 NO. 1 Jen Ai Rd. Sec. 1, Taipei, 100, - - 2014
The objective of this study is to combine nanoparticle design and enteric coating technique to sustain the delivery of an acid-labile drug, lansoprazole (LPZ), in the treatment of acid reflux disorders. Lansoprazole-loaded Eudragit® RS100 nanoparticles (ERSNP-LPZ) as well as poly(lactic-co-glycolic acid) (PLGA) nanoparticles (PLGANP-LPZ) were prepared using a solvent evaporation/extraction ...
Rubach Malte M German Research Center for Food Chemistry, Freising, Germany; Department of Food Science, University of Wisconsin, Madison, WI, - - 2014
Coffee consumption sometimes is associated with symptoms of stomach discomfort. This work aimed to elucidate whether two coffee beverages, containing similar amounts of caffeine, but differing in their concentrations of (β) N-alkanoyl-5-hydroxytryptamides (C5HTs), chlorogenic acids (CGAs), trigonelline, and N-methylpyridinium (N-MP) have different effects on gastric acid secretion in healthy volunteers. ...
Fazzari Marco M Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America ; Fondazione Ri.MED, Palermo, - - 2014
Extra virgin olive oil (EVOO) and olives, key sources of unsaturated fatty acids in the Mediterranean diet, provide health benefits to humans. Nitric oxide (•NO) and nitrite (NO2 (-))-dependent reactions of unsaturated fatty acids yield electrophilic nitroalkene derivatives (NO2-FA) that manifest salutary pleiotropic cell signaling responses in mammals. Herein, the ...
Berté Priscila Elisabeth PE Programa de Pós-Graduação em Ciências Farmacêuticas e Núcleo de Investigações Químico-Farmacêuticas (NIQFAR), Universidade do Vale do Itajaí - UNIVALI, Rua Uruguai, 458, 88302-202, Itajaí, SC, - - 2014
Previous phytochemical studies carried out with Rubus imperialis Chum. Schl. (Rosaceae) have demonstrated the presence of triterpenes (niga-ichigoside F1 and 2β,3β,19α-trihydroxyursolic acid) in this species. The literature indicates that triterpenes are closely related to some pharmacological activities, including antiulcer activity. Therefore, in view of the previous promising results with this ...
1 2 3 4 5 6 7 8 9 10 >