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Shinde Digambar Balaji DB Physical/Materials Chemistry Division, CSIR-National Chemical Laboratory, Dr. Homi Bhabha Road, Pune 411008, India. - - 2014
We report the successful incorporation of bifunctional (acid/base) catalytic sites in the crystalline organocatalytic porous COF (). Due to the presence of acidic (catachol) and basic (porphyrin) sites, shows significant selectivity, reusability, and excellent ability to perform the cascade reaction.
Coulter Ian D ID RAND/Samueli Chair in Integrative Medicine, RAND Corporation 1776 Main Street Santa Monica CA - - 2014
Recommendations of an Expert Panel on 5 central questions addressed during the workshop. The Panel reviewed available scientific literature, workshop presentations, and comments from workshop guests. The Panel unanimously agreed that a military Daily Recommended Intake for long-chain omega-3 fatty acids (FAs) should be established within the context of lowering ...
Lu R - - 2014
Short chain fatty acids (SCFAs) play important roles in periodontal diseases. However, the concentrations of SCFAs in gingival crevicular fluid of patients with aggressive periodontitis are not known. The aim of this intervention study was to investigate the influences of non-surgical periodontal therapy on levels of SCFAs in the gingival ...
Sabour Hadis - - 2014
Context Omega-3 fatty acids have been recently proposed to induce neural improvement in patients with spinal cord injury (SCI) while affecting some hormones including leptin and adiponectin. Objectives We tried to evaluate the effect of omega-3 fatty acids on circulatory concentrations of leptin and adiponectin among these patients. Design This ...
Wadhwani Nisha N Department of Nutritional Medicine, Interactive Research School for Health Affairs, Bharati Vidyapeeth University, Pune Satara Road, Pune 411043, - - 2014
Our previous cross-sectional studies have shown altered proportions of long chain polyunsaturated fatty acids (LCPUFA) in preeclampsia (PE) at the end of pregnancy when the pathology has already progressed. The present longitudinal study for the first time reports fatty acid proportions from 16th week of gestation till delivery and placental ...
Tully Melissa M Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, - - 2014
Oxidative stress has been implicated as a major pathological process underlying CNS disease and trauma. More specifically, acrolein, an unsaturated aldehyde, produced by way of lipid peroxidation, has been shown to play a crucial role in initiating and perpetuating detrimental effects associated with multiple sclerosis and spinal cord injury. In ...
Barman Malin M Food Science, Department of Chemical and Biological Engineering, Chalmers University of Technology, Göteborg, - - 2014
Long-chain polyunsaturated fatty acids (LCPUFAs) are immunomodulatory, but their role in allergy development is controversial. We investigated if proportions of LCPUFAs in serum phospholipids were related to allergic diagnosis, seafood intake and LCPUFA proportions in cord blood. Serum was obtained from 148 birth cohort children at 13-years-of-age. Forty had atopic ...
Figueroa Johnny D JD Center for Health Disparities and Molecular Medicine and Department of Basic Sciences, Loma Linda University School of Medicine, Loma Linda, CA, 92350, - - 2014
Long-chain omega-3 polyunsaturated fatty acids (LC-O3PUFAs) exhibit therapeutic potential for the treatment and prevention of the neurological deficits associated with spinal cord injury (SCI). However, the mechanisms implicated in these protective responses remain unclear. The objective of the present functional metabolomics study was to identify and define the dominant metabolic ...
Yi Youbin Y 1Department of Rehabilitation Medicine, Seoul National University Hospital, Seoul, Republic of - - 2014
Intrathecal chemotherapy including methotrexate is well documented for neurotoxicity of diverse clinical manifestation. Acute or chronic leukoencephalopathy is the most common type of methotrexate-induced neurotoxicity, and subacute myelopathy is rare. Although its pathogenesis is not fully understood, it is postulated that direct damage of methotrexate to the central nervous system ...
Arima Hideyuki H Department of Orthopedic Surgery, Hamamatsu University School of Medicine Japan 1-20-1, Handayama, Higashi-ku, Hamamatsu, Shizuoka 431-3192, - - 2014
The interleukin (IL)-6 pathway plays an important role in recovery after spinal cord injury (SCI). The anti-IL-6 receptor antibody MR16-1 has been shown to suppress inflammation after SCI and promote recovery of motor function. The purpose of this study was to analyze the effects of MR16-1 on the expression patterns ...
Norouzi Javidan A A Brain and Spinal Injury Research Center (BASIR), Tehran University of Medical Sciences, Tehran, - - 2014
Study design:A double-blinded randomized clinical trial.Objectives:The anti-inflammatory and neuroprotective effect of omega-3 fatty acids have been shown so far, but still its influence on clinical measures in spinal cord-injured human models were not known. We tried to investigate changes in disability and dependency scores in chronic traumatic spinal cord-injured patients ...
Yee J K JK Division of Endocrinology, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, - - 2014
Objective:Enhanced fatty-acid desaturation by stearoyl-CoA desaturase enzyme-1 (SCD1) is associated with obesity. This study determined desaturation in the cord plasma of newborns of mothers with and without gestational diabetes (GDM).Study design:Newborns of mothers with GDM (n=21) and without (control, n=22) were recruited. Cord plasma fatty-acid desaturation indices (palmitoleic/palmitic, oleic/stearic ratios) ...
Paterniti Irene - - 2014
Two families of polyunsaturated fatty acid (PUFA), omega-3 (omega-3) and omega-6 (omega-6), are required for physiological functions. The long chain omega-3 PUFAs, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), have significant biological effects. In particular, DHA is a major component of cell membranes in the brain. It is also involved ...
Jacquemyn Y - - 2014
Descriptive study on maternal serum vitamin B12 and folic acid in term pregnancy and in umbilical cord blood that was performed in an inner city hospital with a mixed ethnic population in the region of Flanders in Belgium. A prospective cohort study that took place from April 1 until May ...
Wu Wei W Department of Neurobiology, Shanghai Jiaotong University School of Medicine, Shanghai, PR - - 2013
An urgent unmet need exists for early-stage treatment of spinal cord injury (SCI). Currently methylprednisolone is the only therapeutic agent used in clinics, for which the efficacy is controversial and the side effect is well-known. We demonstrated functional restoration of injured spinal cord by self-assembled nanoparticles composed of ferulic acid ...
Michael-Titus Adina T - - 2013
Omega-3 polyunsaturated fatty acids (PUFAs) are compounds that have a structural role in the nervous system and are essential for neurodevelopment. Results obtained with docosahexaenoic acid and eicosapentaenoic acid show therapeutic potential in neurotrauma. Traumatic brain injury (TBI) and spinal cord injury (SCI) can lead to major disability and have ...
Satkunendrarajah Kajana - - 2013
Long chain polyunsaturated fatty acid, docosahexaenoic acid (DHA) treatment is emerging as a potential treatment for spinal cord injury. Spinal cord injury, which mainly affects young adults, leads to devastating consequences for the person with very few treatment options available. In addition to the initial neuronal and glial cell loss, ...
Gong Nian - - 2013
D-Amino acid oxidase (DAAO) is a flavin adenine dinucleotide-dependent peroxisomal flavoenzyme which is almost exclusively expressed within astrocytes in the spinal cord. DAAO catalyzes oxidation of D-amino acids to hydrogen peroxide, which is a stable and less active reactive oxygen species, and may represent a final form of reactive oxygen ...
Wadhwani Nisha S - - 2013
Our earlier studies both in animals and in humans have indicated that micronutrients (folic acid, vitamin B12) and long-chain polyunsaturated fatty acids, especially docosahexaenoic acid (DHA), are interlinked in the one-carbon cycle, which plays an important role in fetal 'programming' of adult diseases. The present study examines the levels of ...
Kovacheva V P - - 2013
INTRODUCTION: Serum uric acid is a marker for oxidative stress in preeclampsia. Because oxidative stress can result in diminished uterine contractility and impaired vascular relaxation, we hypothesized that an elevated serum uric acid level in women undergoing neuraxial anesthesia for cesarean delivery would be associated with greater uterine atony, as ...
Schizas Nikos - - 2013
Numerous biomaterials based on extracellular matrix-components have been developed. It was our aim to investigate whether a hyaluronic acid-based hydrogel improves neuronal survival and tissue preservation in organotypic spinal cord slice cultures. Organotypic spinal cord slice cultures were cultured for 4 days in vitro (div), either on hyaluronic acid-based hydrogel (hyaluronic ...
Montes R - - 2013
Background/objectives:Fatty-acid status during in-utero development might influence the risk of atopic diseases in early childhood. The aim of this work was to identify the relationship between maternal plasma and cord blood fatty acid (FA) composition and the risk of atopic eczema in the offspring at 14 months of age.Subjects/methods:Two hundred ...
Barman Malin - - 2013
Long-chain polyunsaturated fatty acids (LCPUFAs) reduce T-cell activation and dampen inflammation. They might thereby counteract the neonatal immune activation and hamper normal tolerance development to harmless environmental antigens. We investigated whether fatty acid composition of cord serum phospholipids affects allergy development up to age 13 years. From a population-based birth-cohort ...
Ortega-Senovilla Henar - - 2013
Ligands of peroxisome-proliferator activated receptors (PPARs), such as non-esterified fatty acids (NEFAs), induce expression of angiopoietin-like protein 4 (ANGPTL4). Recently ANGPTL4 has been reported to be a mediator of intracellular adipose lipolysis induced by glucocorticoids. To determine the concentrations of ANGPTL4 in cord serum of neonates born by spontaneous vaginal ...
Lim Siew-Na - - 2012
Omega-3 polyunsaturated fatty acids have been shown to have therapeutic potential in a variety of neurological disorders, including acute traumatic injury of the spinal cord. We addressed the question whether the neuroprotective effect of these compounds after spinal cord injury could also be seen when their level is raised in ...
Miyazaki Shinichiro - - 2012
We previously demonstrated that intrathecal (i.t.) administration of acromelic acid A (Acro-A) induced allodynia in mice and that simultaneous administration of (2S,3R,4R)-3-carboxymethyl-4-(phenylthio)pyrrolidine-2-carboxylic acid (PSPA-1), an Acro-A analogue, attenuated the Acro-A-induced allodynia. To clarify a mechanism of PSPA-1, we attached methyl radical to PSPA-1 and synthesized (2S,3R,4R)-3-carboxymethyl-4-(4-methylphenylthio) pyrrolidine-2-carboxylic acid (PSPA-4) and ...
Escolano-Margarit M Victoria - - 2012
We aimed to investigate the effects of fish oil (FO) supplementation to pregnant women on the maternal and fetal fatty acid profile in plasma and erythrocyte phospholipids (PL) and to identify the best compartment for the assessment of fatty acid status. A multi-centre, double-blind, controlled trial was conducted. Healthy pregnant ...
Zhang Zhen - - 2012
A facile strategy to access 2-pyrazolines and α,β-diamino ketones via SN(2)-type ring-opening of N-(aziridin-2-ylethylidene)hydrazines or N-(aziridin-2-ylbutylidene)hydrazines in the presence of Lewis acid or trifluoromethanesulfonic acid (TfOH) is described in this context.
Moriyama Katsuhiko - - 2012
The Hofmann-type rearrangement of aromatic and aliphatic imides using KBr as the catalyst proceeded to provide aromatic and aliphatic amino acid derivatives. We have also developed a new synthetic route to gabapentin with this method.
Yokosaka Takuya - - 2012
An acid-promoted novel skeletal rearrangement is described. Using trifluoroacetic acid as the acid promoter, an intramolecular ipso-Friedel-Crafts-type addition of phenols to 3-alkylidene indolenium cations, formation of iminium cations through rearomatization of the spirocyclohexadienone units, and intramolecular Pictet-Spengler reaction proceeded sequentially, producing tricyclic indole derivatives.
López-Duarte Ismael - - 2012
Zinc phthalocyanine sensitizers that contain phosphinic acid anchoring groups have an overall conversion efficiency of 3.24 % under 1 sun in a dye-sensitized solar cell (DSSC). M. K. Nazeeruddin, T. Torres, M. Grätzel, and co-workers demonstrate in their Communication (DOI: 10.1002/anie.201105950) that the phosphinic acid groups provide a stronger binding ...
Fu Yingzi - - 2012
A new strategy is established for detecting chiral amino acids based on the electron transfer from hemoglobin Fe(ii) to Cu(ii) in copper complexes of the amino acids. The sensor shows a highly selective recognition of arginine enantiomers.
Demont M - - 2012
The effect of pH, nature of acid and temperature on trace element migration from ceramic ware treated with 18 commercially available glazes was studied. Besides of the well-studied lead and cadmium, migration of other toxic and non toxic elements such as aluminum, boron, barium, cobalt, chrome, copper, iron, lithium, magnesium, ...
Lu Jin - - 2012
Albumin transports both fatty acids and zinc in plasma. Competitive binding studied by isothermal titration calorimetry revealed that physiologically relevant levels of fatty acids modulate the Zn-binding capacity of albumin, with far-reaching implications for biological zinc speciation. The molecular mechanism for this effect is likely due to a large conformational ...
Stewart Robin J C - - 2012
Fe bioavailability can be manipulated by the nutritional composition of a meal. Ascorbic acid and unidentified components of meat, fish and poultry, but particularly beef, all appear to enhance the absorption of non-haem Fe. The aim of the present study is to identify whether extracts of green-lipped mussels (GLM; Perna ...
Urbieta M Sofía - - 2012
Two acidic hot springs close to the crater of Copahue Volcano (Neuquén, Argentina) are the source of the Río Agrio. The river runs several kilometres before flowing into Caviahue Lake. Along the river, temperature, iron, other metal and proton concentrations decrease gradually with distance downstream. From the source to the ...
Kale A - - 2012
Our objective was to measure amniotic fluid amino acid concentrations in pregnant women diagnosed as having fetuses with spina bifida in the second trimester of pregnancy. Fifteen pregnant women who had fetuses with spina bifida detected by ultrasonography (spina bifida group) in the second trimester and 19 women who had ...
Oliveira Olívia R C - - 2012
Considering the importance of long chain polyunsaturated fatty acids to fetal development and the lack of studies that have compared the status of fatty acids between adolescents and adults mothers, the purpose of this study was to evaluate the composition of fatty acids in maternal and umbilical cord plasma from ...
Reinoso-Maset Estela - - 2012
Organic complexing agents, such as ethylenediaminetetraacetic acid (EDTA), nitrilotriacetic acid (NTA) and picolinic acid, have been widely used at nuclear sites and are therefore found as common co-contaminants in radioactive contaminated land. This study has explored the mechanisms by which these three complexing agents affect the sorption of Th(IV) to ...
Varga Balázs R - - 2011
We designed and synthesised carboxymethylmonobenzocyclooctyne (COMBO) through a four-step reaction pathway. COMBO is a new, structurally simple, non-fluorinated, and directly conjugable copper-free click reagent, which shows excellent reaction kinetics, as also evidenced by theoretical calculations. Additionally, the carboxylic acid appendage allows further conjugation to biomolecules or fluorescent labels. The utility ...
Lin Emme C K - - 2011
AX10185, the phenyl amide of xanthurenic acid, was found to be a sub-100nM inhibitor of Lp-PLA(2). However, in the presence of EDTA the inhibitory activity of AX10185 was extinguished while the enzymatic activity of Lp-PLA(2) did not change. Subsequent metal screening experiments determined the inhibition to be Zn(2+) dependent. Structure-activity ...
White Malcolm F - - 2011
Several unexpected reports of iron-sulphur clusters in nucleic acid binding proteins have recently appeared in the literature. Once thought to be relatively rare in these systems, iron-sulphur clusters are now known to be essential components of diverse nucleic acid processing machinery including glycosylases, primases, helicases, nucleases, transcription factors, RNA polymerases ...
Hasanzadeh Mohammad - - 2011
A new chemically modified carbon paste electrodes based on Fe (III) schiff base (Fe (III)-SBMCP)-containing graphite pastes were prepared and evaluated as electrochemical sensor for the voltammetric determination of mefenamic acid and indomethacin in aqueous solutions. The measurements were carried out by application of the differential pulse voltammetry (DPV) method ...
Takahama Umeo - - 2011
Iron(III) ingested as a food component or supplement for iron deficiencies can react with salivary SCN- to produce Fe(SCN)2+ and can be reduced to iron(II) by ascorbic acid in the stomach. Iron(II) generated in the stomach can react with salivary nitrite and SCN- to produce nitric oxide (NO) and FeSCN+, ...
Nikolić Ružica - - 2011
This study was carried out with the aim of identifying the effects of consuming sour-tasting food and refreshing drinks on the bone tissue of teeth among teenagers. The cumulative effect of a year-long exposure of teeth to the erosive effects of a model system of acidic media (citric acid, lactic ...
Liu Yi - - 2011
An unexpected recognition of β-cyclodextrin (CD) from α- and γ-CDs was achieved. The emission from a diboronic acid-containing tetraphenylethene (TPEDB) was amplified upon addition of β-CD, whereas there was almost no response for α-, and γ-CDs. TPEDB is proposed to be anchored onto the wide rim of β-CD through the ...
Upare Pravin P - - 2011
Copper/silica nanocomposite catalysts prove efficient for the direct hydrocyclization of biomass-derived levulinic acid to cyclic 2-methyltetrahydrofuran in the vapor phase, at moderate hydrogen pressures. A nickel-promoted copper/silica catalyst with a high copper loading (72 wt %) is particularly effective for the direct hydrocyclization (89 % selectivity). The catalysts are stable during long-term experiments, ...
Wang W - - 2011
Background/Objectives:Little is known about the long-term effects of maternal multi-micronutrient supplementation on the growth of children during early childhood. In this follow-up study, the effects of maternal supplementation with multi-micronutrients in pregnancy on postnatal child growth are examined.Subjects/Methods:A longitudinal follow-up of a subset of newborns (n=1388) whose mothers were randomly ...
Sanchez Irama - - 2011
The aim of this study was to investigate the effect of a chelated zero valent iron as catalyst on the oxidation of six organic acids that are generally found in olive mill wastewater. The reaction was carried out in a stirred tank reactor under extremely mild conditions, a temperature of ...
Zhang Hui - - 2011
Choline, as a marker of cholinergic activity in brain tissue, is very important in biological and clinical analysis, especially in the clinical detection of the neurodegenerative disorders disease. This work presents an electrochemical approach for the detection of choline based on prussian blue modified iron phosphate nanostructures (PB-FePO(4)). The obtained ...
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