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Houghton Lisa A - - 2009
BACKGROUND: Many lactating women in North America are exposed to high synthetic folic acid intakes because of food fortification and vitamin supplement use. Few data exist on the potential long-term effect of high folic acid intakes on milk folate concentrations, whereas no data are available on the effect of supplemental ...
Tsai Michael Y - - 2009
Moderate hyperhomocysteinemia is associated with many diseases. Major factors affecting plasma total homocysteine (tHcy) concentrations include folate concentrations and polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene. Because U.S.-mandated fortification of grain products with folic acid has improved folate and tHcy status in Americans, we investigated the effect of the MTHFR ...
Bhattacharya Shiladitya - - 2008
Folic acid was derivatized specifically at its gamma-carboxyl group to retain its ligand-binding activity to the folate receptor alpha (FRalpha) present on HeLa cells. Amphiphilic molecules labeled with folic acid were prepared by conjugation of long-chain primary amines directly or via diamine linkers to the gamma-carboxyl group of folic acid. ...
Martinez-Alvernia Efrain A - - 2008
OBJECTIVES: We determined the location of matrix metalloproteinases (MMP) 2 and 9, and whether the luminal perichondrium or transforming growth factor (TGF) beta3 influences the presence of MMP-2 and/or -9 within the chondrocytes of the cricoid cartilage. METHODS: Subglottises from 15 neonatal mice were divided into group A (N = ...
Kalmbach Renee D - - 2008
Dihydrofolate reductase (DHFR) catalyzes the reduction of folic acid to tetrahydrofolate (THF). A 19-bp noncoding deletion allele maps to intron 1, beginning 60 bases from the splice donor site, and has been implicated in neural tube defects and cancer, presumably by influencing folate metabolism. The functional impact of this polymorphism ...
Wang Song - - 2008
The hemocompatibility of silk fibroin (SF) was improved with ferulic acid (FA) by graft polymerization. Ferulic acid is an active ingredient of many Chinese herbal medicines, such as Chuanxiong (Rhizoma ligustici wallichii), Danggui (Angelica sinensis) and Awei (Asafoetida giantfennel), which have been used to treat cardiovascular diseases by Chinese physicians ...
Chan Annabelle C - - 2008
OBJECTIVES: To ascertain changes in: women's knowledge of the role of folic acid in the prevention of neural tube defects (NTDs); intake of folic acid among pregnant women; and prevalence of NTDs in South Australia. DESIGN, SETTING AND PARTICIPANTS: Computer-assisted telephone interviews of South Australian households from 1994 to 2007 ...
Elsemann Rogério Brasiliense - - 2008
This in situ study evaluated the Shore A hardness and phthalate concentration of 3 tissue conditioners (Coe-Comfort, Dura Conditioner, Softone) inserted into grooves on 9 maxillary dentures. Data were collected at baseline and after 3, 7, and 14 days of denture use. All materials showed a decrease in phthalate concentration ...
Koren Gideon - - 2008
ABSTRACTQUESTION The new Motherisk Guidelines suggest 5 mg/d of folic acid. Why was the dose increased? What is the time frame for taking such a dose?ANSWER Recent data from Ontario reveal that 40% of women of reproductive age still do not achieve therapeutic systemic levels of folate needed to prevent ...
Flynn Mary A T - - 2008
Adequate intake of folic acid by women during very early pregnancy can markedly reduce risk of the development of neural-tube defects (NTD). The effectiveness of advice to women to take folic acid supplements is limited, mainly because 50% of pregnancies are unplanned. However, mandatory folic acid food fortification programmes in ...
Mills James L - - 2009
Many neural tube defects can be prevented if women take folic acid around the time of conception. However, the majority of women do not take folic acid at the critical time, so the US government required that food be fortified with folic acid effective January 1, 1998. Whether the amount ...
Mosley Bridget S BS Department of Pediatrics, University of Arkansas for Medical Sciences and Arkansas Children's Hospital Research Institute, Little Rock, Arkansas 72202, - - 2009
Rates of neural tube defects have decreased since folic acid fortification of the food supply in the United States. The authors' objective was to evaluate the associations between neural tube defects and maternal folic acid intake among pregnancies conceived after fortification. This is a multicenter, case-control study that uses data ...
Yao Zhiyi - - 2008
Optically active supramolecular complexes of water-soluble achiral polythiophene (PT) derivatives, PMTPA or PMTEA (Chart 1), and folic acid have been prepared; and the complex formation processes have been studied by absorption, emission, and circular dichroism (CD) spectroscopies. The complexes exhibited unique split-type induced CDs in the pi-pi* transition region of ...
de Oliveira Penido Marcus Luiz - - 2008
This paper discusses the development of a series of sulfur-containing compounds that show an interesting in vivo activity against infection by Schistosoma mansoni. These substances include the aminoalkanethiols, aminoalkanethiosulfuric acids and aminoalkyl disulfides, among others. Although the aminoethanethiols and their disulfide derivatives have presented a relatively high toxicity for the ...
Prey S - - 2009
BACKGROUND: Methotrexate is a folic acid antagonist widely used for the treatment of inflammatory disorders for more than 50 years. Methotrexate is a standard systemic therapy for severe psoriasis and rheumatoid arthritis. Folic acid supplementation has been advocated to limit the toxicity of methotrexate on blood cells, gastrointestinal tract and ...
Bae Ji-Hoon - - 2009
INTRODUCTION: As there are few reports on the difficulties of removing the locking compression plate (LCP), we prospectively investigated the incidence and difficulties in 58 patients in whom various types of LCPs were taken. METHODS: From January 2004 to December 2007, we have removed 159 5.0-self tapping locking screws and ...
Frauendorfer Felix - - 2008
Application of a comparative aroma extraction dilution analysis on unroasted and roasted Criollo cocoa beans revealed 42 aroma compounds in the flavor dilution (FD) factor range of 1-4096 for the unroasted and 4-8192 for the roasted cocoa beans. While the same compounds were present in the unroasted and roasted cocoa ...
Johnson Adam P - - 2008
Miller's 1950s experiments used, besides the apparatus known in textbooks, one that generated a hot water mist in the spark flask, simulating a water vapor-rich volcanic eruption. We found the original extracts of this experiment in Miller's material and reanalyzed them. The volcanic apparatus produced a wider variety of amino ...
Stirban Alin - - 2008
Zycose is a newly released (2006) combined medication containing folic acid (1 mg) benfotiamine (150 mg) and benzamine (850 mg), a proprietary blend of para-aminobenzoic acid (PABA), vitamin E and alpha-lipoic acid (ALA). Zycose protects vascular, retinal and kidney function by improving cellular health and promoting peripheral nerve health in ...
Konwick Brad J - - 2008
Perfluoroalkyl acids (PFAAs) are widespread contaminants emanating from, among other sources, the production/degradation of fluorinated chemicals used in surface repellant applications, such as carpet manufacturing. The goal of the present study was to assess the concentrations of PFAAs, including perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), perfluorodecanoic acid ...
Prue Christine E - - 2008
Each year, approximately 3000 pregnancies in the United States are affected by neural tube defects (NTDs), serious birth defects of the brain and spine. Daily periconceptional consumption of folic acid can reduce the incidence of NTDs by 50%-70%. This study was designed to understand Latina mothers' folic acid awareness, knowledge, ...
Guo Lei - - 2008
Usnic acid is a prominent secondary lichen metabolite that has been used for various purposes worldwide. Crude extracts of usnic acid or pure usnic acid have been marketed in the United States as dietary supplements to aid in weight loss. The US Food and Drug Administration (FDA) received 21 reports ...
Iacovino Michelina M Department of Molecular Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390, - - 2009
Maintenance of an intact mitochondrial genome is essential for oxidative phosphorylation in all eukaryotes. Depletion of mitochondrial genome copy number can have severe pathological consequences due to loss of respiratory capacity. In Saccharomyces cerevisiae, several bifunctional metabolic enzymes have been shown to be required for mitochondrial DNA (mtDNA) maintenance. For ...
Younis Islam R - - 2009
The vitamin folic acid has received considerable attention because of its role in decreasing the risk of neural tube birth defects, and its potential role in reducing the risks of cardiovascular and psychiatric diseases. A significant concern is the quality of commercially available folic acid products. We evaluated the pharmaceutical ...
Shimmura T - - 2008
1. The objective was to determine the relation between social rank and use of resources in a small furnished cage with sufficient resources per hen (SF) and a commercial large one with less adequate allowance of facilities per hen (LF). 2. Ninety-two cross layers were used. At the age of ...
Alemdaroglu N Ceren - - 2008
Previous in vitro studies using Caco-2 cell monolayers suggested a possible interaction between green and black tea and folic acid at the level of intestinal absorption. The main purpose of the present study was to investigate a possible pharmacokinetic interaction between tea and folic acid in healthy volunteers. In an ...
Vir Sheila C - - 2008
BACKGROUND: Weekly iron-folic acid supplementation in small-scale research trials and as administered in institutions has been demonstrated to be effective in reducing anemia in adolescent girls. OBJECTIVE: To assess the effectiveness of weekly iron-folic acid supplementation in a large-scale project in reducing the prevalence of anemia in adolescent girls. METHODS: ...
Kalmbach Renee D - - 2008
The implementation of folic acid fortification in the United States has resulted in unprecedented amounts of this synthetic form of folate in the American diet. Folic acid in circulation may be a useful measure of physiologic exposure to synthetic folic acid, and there is a potential for elevated concentrations after ...
Bassene Jean-Baptiste - - 2008
Sugar, organic acid, and carotenoid are the most important indicators of fruit taste and nutritional and organoleptic quality. These components were studied on fruit pulp of the cybrid between Willow leaf mandarin ( Citrus deliciosa Ten.) and Eureka lemon [ Citrus limon (L.) Burm.] and the two parents. The cybrid ...
Elango M - - 2008
The structural motifs responsible for the formation of bowls, balls and sheets of orthoboric acid were pointed out in an earlier publication (Elango et al. J. Phys. Chem. A 2005, 109, 8587). It is shown in the present study that metaboric acid forms similar bowls, balls and sheets, despite the ...
Benison Kathleen C - - 2008
"Hairy blobs" are unusual clumps of organic bodies and sulfate crystals that have been found in evaporite minerals grown in acid saline lakes. Here, we document modern hairy blobs in halite and gypsum from 5 modern acid saline lakes in southern Western Australia, and Permian hairy blobs trapped in halite ...
Bognár Márta - - 2008
BACKGROUND: Neural tube defects (NTDs) are some of the most common congenital anomalies. Proper folic acid supplementation is a dominant risk factor, which has been shown to decrease the incidence of NTDs. In Canada, the incidence of neuroblastoma has presented a considerable decrease of 60% as a result of enrichment ...
Mytton J - - 2008
OBJECTIVE: Some congenital anomaly registers are collecting data on risk factors for pregnancies affected by anomalies; yet the quality of that information is rarely assessed. We assessed the quality of the risk factor data in the South West Congenital Anomaly Register (SWCAR) through a review of the data held on ...
Bagdonaite Kristina - - 2008
In this study different Arabica and Robusta coffee beans from different regions of the world were analyzed for acrylamide after roasting in a laboratory roaster. Due to the complex matrix and the comparably low selectivity of the LC-MS at m/ z 72, acrylamide was analyzed after derivatization with 2-mercaptobenzoic acid ...
Vlahov Iontcho R - - 2008
Efficient syntheses of folate conjugates of tubulysins and their hydrazides 1a-d are described. These water soluble folate receptor (FR) targeted conjugates are derivatives of folic acid and the potent cytotoxic agents: tubulysin A, B, or their respective hydrazides, connected in regioselective manner via a hydrophilic peptide spacer and a reducible ...
Bhurani D - - 2008
The use of MTX for GVHD prophylaxis may be associated with significant toxicity, including hepatotoxicity, graft failure and mucositis. Folinic acid may be involved in the amelioration of MTX toxicity. There is, however, no consensus regarding its use. A survey was conducted in Australian and New Zealand transplant centres (n=22) ...
Tamim H - - 2009
OBJECTIVE: The objective of the present study was to assess the prevalence and determinants of preconceptional folic acid supplement use among pregnant women in Lebanon. DESIGN/SETTING/SUBJECTS: The study was a descriptive epidemiological study. Analysis was performed on 5280 deliveries admitted to twelve member hospitals of the National Collaborative Perinatal Neonatal ...
Abed Raeid M M - - 2008
Variations in morphology, fatty acids, pigments and cyanobacterial community composition were studied in microbial mats across intertidal flats of the arid Arabian Gulf coast. These mats experience combined extreme conditions of salinity, temperature, UV radiation and desiccation depending on their tidal position. Different mat forms were observed depending on the ...
Timmermans Sarah - - 2008
OBJECTIVE: Recommendations on folic acid use to prevent neural tube defects have been launched in several countries. Adequate folic acid use seems to be low. This study assesses the prevalence of folic acid use and identifies its determinants. METHODS: The study was embedded in the Generation R Study Rotterdam, the ...
Moat Stuart J - - 2008
Cardiovascular disease (CVD) is a major cause of morbidity and mortality in developed countries. However, traditional risk factors cannot fully account for this. In the last 20 years, there has been an explosion of interest in plasma total homocysteine (tHcy) as a potential modifiable risk factor for CVD. Recent meta-analyses ...
Lippi Giuseppe - - 2008
Although macrocytosis might occur with frequency in patients with thyroid disorders, there is controversial information on the metabolic relationship between thyroid stimulating hormone (TSH), folic acid and B12 in the general population. We performed a retrospective analysis to retrieve results of serum folic acid, B12, and TSH performed on consecutive ...
Hirsch E - - 2008
OBJECTIVES: This study compares tissue-absorbed and effective doses of the cone beam CT (CBCT) units, the Veraviewepocs 3D and the 3D Accuitomo, in different protocols. METHODS: The absorbed organ doses were measured using an anthropomorphic phantom loaded with thermoluminescent dosemeters (TLDs) in 16 sensitive organ sites. Both CBCT units were ...
Little J J Human Genome Epidemiology, University of Ottawa, Ottawa, Ontario, - - 2008
We sought to determine the associations between nonsyndromic cleft lip with or without cleft palate (CL-P) and cleft palate only (CP) and maternal intake of dietary folate and supplemental folic acid, in an area where the prevalence at birth of neural tube defects has been high and flour is not ...
Sukontason Kabkaew L - - 2008
In forensic investigations, all immature stages of flies (egg, larvae, and puparium) can serve as entomological evidence at death scenes. These insects are primarily used to estimate the post mortem interval (PMI), but can also be involved in the analysis of toxic substances, determining manner of death, and in indicating ...
Cherian Bibin Mathew - - 2008
Alkali treatment coupled with high pressure defibrillation and acid treatment have been tried on banana fibers obtained from the pseudo stem of the banana plant Musa sapientum. The structure and morphology of the fibers have been found to be affected on the basis of the concentration of the alkali and ...
Lasry Inbal - - 2008
Hereditary folate malabsorption (HFM) patients harbor inactivating mutations including R113S in the proton-coupled folate transporter (PCFT), an intestinal folate transporter with optimal activity at acidic pH. Here we identified and characterized a novel R113C mutation residing in the highly conserved first intracellular loop of PCFT. Stable transfectants overexpressing a Myc-tagged ...
Jiménez Girón A - - 2008
The determination of folic acid and its two main serum metabolites, 5-methyltetrahydrofolic acid and tetrahydrofolic acid, has been accomplished using four-way data modelled by the third-order multivariate calibration methods unfolded and N-dimensional partial least-squares (U-PLS and N-PLS), in combination with the separate procedure known as residual trilinearization (RTL). The four-way ...
Olsen Sjurdur F - - 2008
Evidence from controlled trials suggests that ingestion of 0.4 mg of folic acid per day in the periconceptional period is effective in preventing neural tube defects (NTD). For this reason, most countries recommend that women planning pregnancy take folic acid supplements in the periconceptional period, and some countries even fortify ...
de Jong-van den Berg Lolkje T W - - 2008
In November of 1993, the Dutch government recommended daily folic acid supplementation of 0.4 or 0.5 mg for all women planning pregnancy, starting 4 weeks before conception until 8 weeks after. In 1995, a one-time mass media campaign was conducted, and due to this campaign, the use of folic acid ...
Azcarate M P - - 2008
The natural occurrence of Alternaria mycotoxins in Argentinean wheat from the zone 5 South during the 2004 to 2005 harvest was investigated in 64 wheat samples. All samples were highly contaminated with a wide range of fungal species. Alternaria was found as the main component of the mycota, with an ...
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