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Montigny Cédric C CNRS - CEA - Université Paris Sud, - - 2014
Sarcolipin (SLN) is a regulatory peptide present in sarcoplasmic reticulum (SR) from skeletal muscle of animals. We find that native rabbit SLN is modified by a fatty acid anchor on Cys9 with a palmitic acid in about 60% and, surprisingly, an oleic acid in the remaining 40%. SLN used for ...
Wang Jian Ping JP Key Laboratory of Animal Disease-Resistance of China Ministry of Education, Sichuan Agricultural University, Ya'an, China; Institute of Animal Nutrition, Sichuan Agricultural University, Ya'an, - - 2014
Two experiments were conducted to assess the feeding value of water-soaked barley (WB) as a replacement for dehulled barley (DB) in pigs. In experiment (Exp.) 1, eight barrows (body weight = 30.56 ± 0.78 kg) were fitted with a T-cannula and allotted to a duplicated 4 × 4 Latin square design: WB10, 100g/kg WB; WB20, 200 g/kg WB; ...
Suzzi Giovanna G Faculty of Biosciences and Technologies for Agriculture Food and Environment, University of Teramo, Via Carlo R. Lerici 1, 64023, Mosciano S. Angelo, - - 2014
Pig rennet is traditionally used in Pecorino di Farindola cheese. Different Pecorino cheeses, obtained using calf, kid and pig rennet, were compared in terms of fatty acids, volatile molecules profiles, texture, and sensory properties during ripening. The rennet influenced the fatty acid composition of cheeses although palmitic, myristic and oleic ...
Bai Xiumei X Laboratory of Developmental Nutrition, Department of Animal Science, North Carolina State University, Raleigh, NC; - - 2014
Utilization of energy-dense lipid fuels is critical to the rapid development and growth of neonates. To increase efficiency of milk fat utilization by newborn pigs, the effect of clofibrate on in vivo and in vitro long-chain fatty acid (LCFA) oxidation was evaluated. Newborn male pigs were administered 5 mL of ...
Bochicchio D D 1C.R.A. Consiglio per la ricerca e la sperimentazione in agricoltura,Unità di ricerca per la suinicoltura,Via Beccastecca 345,41018 S. Cesario s. P. - - 2014
The mobilization of fatty acids during food deprivation is a selective process studied in different species (humans, rodents, birds, viverrids). The aim of this work was to study the effect of fasting on selective mobilization in commercial pigs. A total of 16 barrows (Large White×Landrace (167 kg±12.5 kg live weight) ...
Wang Cheng C Institute of Environmental Science and Technology, Zhejiang University, Yuhangtang Road 866#, Hangzhou 310058, - - 2014
Despite the many benefits of biochar amendment in composting, little information is available about its effects on organic matter humification during the process. In this study the analytical results for two in-vessel composting piles were compared, one amended with biochar (VPSB, pig manure+sawdust+biochar) and the other serving as a control ...
Mörlein Daniel D Department of Animal Sciences, University of Göttingen, D-37075 Göttingen, Germany. Electronic address: - - 2014
This exploratory study investigated the variability of fatty acid composition in entire male pigs with extremely divergent levels of boar taint compounds. Fatty acids were quantified in back fat samples from 20 selected carcasses of Pietrain*F1 sired boars (average carcass weight 84kg) with extremely low (LL) or extremely high (HH) ...
Zhang Yaping Y Department of Biophysics and structural biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & School of Basic Medicine, Peking Union Medical College, Beijing, PR - - 2014
Changes in the levels of lipids are associated with breast cancer (BC). Disease-specific serum free fatty acids (FFAs) were quantified using chip-based direct-infusion nanoelectrospray ionization-Fourier transform ion cyclotron resonance mass spectrometry (CBDInanoESI-FTICR MS) in the negative ion mode. Multiple point internal standard calibration curves between the concentration ratios of fatty ...
Elsayed Heba E HE Department of Basic Pharmaceutical Sciences, School of Pharmacy, University of Louisiana at Monroe, 71201, Monroe, Louisiana, USA; Department of Pharmacognosy, Faculty of Pharmacy, Helwan University, 11795, Helwan, Cairo, - - 2014
Bioassay-guided fractionation of Terminalia bentzoe L. leaves methanol extract identified the known triterpene oleanolic acid (1) as its major breast cancer cell migration inhibitor. Further chemical optimization afforded five new (9-12 and 15) and seven known (4-8, 13, and 14) semisynthetic analogues. All compounds were tested for their ability to ...
Tommonaro Giuseppina G National Research Council of Italy, Institute of Biomolecular Chemistry, CNR-ICB , Pozzuoli-Naples , Italy - - 2014
Abstract The acetylcholinesterase inhibitory and/or antitumour activities of amino-, thio- and ester-derivatives of avarol selected were evaluated for the first time at in vitro conditions. Avarol-3',4'-dithioglycol (1) and avarol-4'-(3)mercaptopropionic acid (3) were shown to be the best inhibitors of the enzyme tested (0.50 µg and IC50 0.05 mM and 0.50 µg and IC50 ...
Haug Anna - - 2014
The conversions of the n-3 and n-6 fatty acid of plant origin to the C20 and C22 very long chain fatty acids (LCPUFAs) is regulated by several cellular enzymes such as elongases and desaturases. Sixty-five male one-day old chickens (Ross 308) were randomly divided into four groups and given one ...
Goldeman Waldemar W Wrocław University of Technology, Department of Organic Chemistry, Wybrzeże Wyspiańskiego 27, Wrocław 50-370, Poland. Electronic address: - - 2014
A series of aromatic and aliphatic bis[aminomethylidene(bisphosphonic)] acids was synthesized in the reaction of triethylphosphite with isonitriles followed by hydrolysis or dealkylation. The in vitro anti-proliferative effect of all synthesized tetraphosphonic acids against MCF-7 breast cancer cells, J774E macrophages and HL-60 promyelocytic leukemia cells was determined. Three aromatic derivatives (5a, ...
Pfeifer Agathe A Institute of Meat Hygiene, Meat Technology and Food Science, University of Veterinary Medicine Vienna, Veterinärplatz 1, 1210 Vienna, - - 2014
We investigated the influence of lactic acid treatment of pheasant meat before vacuum-packaged storage of 3, 7, and 10 d at +6°C on microbiota and pH. Breast muscle samples were collected from carcasses of slaughtered as well as from hunted (shot) wild pheasants. Immersion of meat samples in 3% (wt/wt) ...
Høstmark Arne Torbjørn - - 2014
Many health effects of oils rich in oleic acid (OA, 18:1 n9) seem to be opposite those of arachidonic acid (AA, 20:4 n6), i.e. concerning cardiovascular risk. In recent studies in humans and in the rat we observed that percentages of OA and AA were inversely related, raising the question ...
Mili Evi Dragan - - 2014
The objective of the study was to present information about the chemical composition, the fatty acids profile, and cholesterol content of chicken meat in order to investigate the impact of chicken meat consumption on cardiovascular risk in the general population. A total of 48 6-wk-old broiler chickens broilers from two ...
Zheng Ken Y Z KY Department of Biology, Hanshan Normal University, Chaozhou, Guangdong, - - 2014
Danggui Buxue Tang, an ancient formula composed of Astragali Radix and Angelicae Sinensis Radix, has been used for treating menopausal irregularity in women for more than 800 years in China. In Danggui Buxue Tang, the complete functions of Astragali Radix require the assistance of Angelicae Sinensis Radix, and both herbs ...
Ali Safdar S Department of Computer and Information Sciences, Pakistan Institute of Engineering, and Applied Sciences, Nilore, Islamabad, 45650, Pakistan, - - 2014
Development of an accurate and reliable intelligent decision-making method for the construction of cancer diagnosis system is one of the fast growing research areas of health sciences. Such decision-making system can provide adequate information for cancer diagnosis and drug discovery. Descriptors derived from physicochemical properties of protein sequences are very ...
Karabacak Ali A High Graduate School of Karapınar Aydoğanlar, University of Selçuk, 42400 Konya, - - 2014
This study was conducted to compare fatty acid composition and content of conjugated linoleic acid (CLA) in different regions of sheep carcasses. Lambs of the Dağlıç breed were used for this purpose. Subsequent to a 68-day period of intensive fattening, fatty acids were examined in samples taken from the legs, ...
Pouchieu Camille C Sorbonne Paris Cité, Nutritional Epidemiology Research Team (EREN), Epidemiology and Biostatistics Center, Inserm U1153, Inra U1125, Cnam, University Paris 13, University Paris 5, University Paris 7, Bobigny, - - 2014
Mechanistic data suggest that different types of fatty acids play a role in carcinogenesis and that antioxidants may modulate this relationship but epidemiologic evidence is lacking. Our aim was to investigate the association between plasma saturated, monounsaturated and polyunsaturated fatty acids (SFAs, MUFAs and PUFAs) and overall and breast cancer ...
Omoyeni Olubunmi A OA Department of Chemistry, University of the Western Cape, Private Bag X17, Bellville 7535, South - - 2014
Three known triterpenoids, namely ursolic acid (1), and the 27-E- and 27-Z-p-coumaric esters of ursolic acid (compounds 2, 3), were isolated together with a new triterpene 2,3-seco-taraxer-14-en-2,3-lactone [pycanocarpine (4)] from an ethanolic extract of Pleiocarpa pycnantha leaves. The structure of 4 was unambiguously assigned using NMR, HREIMS and X-ray crystallography. ...
Baldeón Manuel E ME Facultad de Ciencias de la Salud, Universidad de las Américas, Quito, - - 2014
Because of increased incidence of teenage births and high prevalence of lactation in Latin America, we determined the patterning of free amino acids (FAAs) in breast milk of 65 primiparous Ecuadorian women of varying ages (14-27 years). An automatic amino acid analyzer quantified levels of FAAs in milk samples obtained at ...
Cheng Chien-Shan CS School of Chinese Medicine, The University of Hong Kong, Pokfulam, Hong - - 2014
Molecular targeted therapy has been developed for cancer chemoprevention and treatment. Cancer cells process a fundamental change in its bioenergetic metabolism from normal cells on an altered lipid metabolism, also known as the de novo fatty acid synthesis, for sustaining their high proliferation rates. Fatty acid synthesis is now associated ...
Galione Antony A Department of Pharmacology, University of Oxford, Oxford OX1 3QT, United - - 2014
In addition to mobilizing Ca(2+), NAADP plays a role in modulating the luminal pH (pHL) of acidic stores of the endolysosomal system. The effects of NAADP on pHL have been most extensively studied in the sea urchin egg, both in the intact egg and in egg homogenates. Related observations have ...
Gülcemal Derya - - 2013
Four oleanane-type triterpene glycosides were isolated from the methanol extract of the roots of Paronychia anatolica subsp. balansae along with three known oleanane-type triterpene glycosides. Structures of the new compounds were established as 3-O-β-D-glucuronopyranosyl-28-O-[α-L-rhamnopyranosyl-(1→2)-β-D-quinovopyranoside] zahnic acid, 3-O-β-D-glucuronopyranosyl-28-O-[β-D-xylopyranosyl-(1→4)-α-L-rhamnopyranosyl-(1→2)-β-D-quinovopyranoside] zahnic acid, 3-O-β-D-glucuronopyranosyl-28-O-[α-L-arabinofuranosyl-(1→2)-β-D-quinovopyranoside] zahnic acid, 28-O-[α-L-rhamnopyranosyl-(1→4)-β-D-glucopyranosyl-(1→6)-β-D-glucopyranosyl]-medicagenic acid, by using 1D and 2D-NMR techniques ...
Nishimura Renata Y RY Program in Community Health in the Ribeirão Preto Medical School at the São Paulo University, São Paulo, - - 2013
The aim of this study was to investigate how maternal polyunsaturated fatty acid intake at different periods during pregnancy affects the composition of polyunsaturated fatty acids in mature human milk. A prospective study was conducted involving 45 pregnant women, aged between 18 and 35 y, who had full-term pregnancies and ...
Arshad Muhammad Sajid - - 2013
In response to recent assertions that synthetic antioxidants may have the potential to cause toxic effects and to consumers' increased attention to consuming natural products, the poultry industry has been seeking sources of natural antioxidants, alone or in combination with synthetic antioxidants that are currently being used by the industry. ...
Hopperton Kathryn E - - 2013
Fatty acid synthase is over-expressed in many cancers and its activity is required for cancer cell survival, but the role of endogenously synthesized fatty acids in cancer is unknown. It has been suggested that endogenous fatty acid synthesis is either needed to support the growth of rapidly dividing cells, or ...
Geldenhuys Greta - - 2013
There is no scientific research regarding Egyptian goose (Alopochen aegyptiacus) meat; therefore, a chemical analysis to establish the nutritional characteristics of the breast portion is described. Meat from guineafowl, Pekin duck, ostrich, and broiler chicken were used as a reference. The high intramuscular fat content of Egyptian goose meat (5.6 ...
Trombino Sonia - - 2013
Aim: The aim of the present study was to prepare a hydrogel, based on ellagic acid and glycine, embedded with folic acid, as a subcutaneous implant for the treatment of breast cancer. The function of folic acid is to selectively and actively target tumor cells which are well-known to overexpress ...
Goli T T CIRAD, UMR QualiSud, Food Process Engineering TA B-95/15, 73 rue JF Breton, 34398 Montpellier Cedex 5, France. Electronic address: - - 2013
Turkey breast cubes underwent acidic marination in the presence of salt. The transfer of water, salt and acid was measured, and texture was assessed on the cooked meat. While significant mass gains were observed during marination, from 20minutes of immersion onwards, only long durations produced an overall matter balance greater ...
Franco D - - 2013
Abstract 1. Carcass cuts, chemical composition, colour, textural parameters, fatty acid and amino acid profiles, macro- and micromineral content and sensory properties of breast and drumstick meat from 10 month old common pheasant produced in an extensive rearing system were analysed. 2. Breast muscle was characterised by a high concentration ...
Zou Zuquan - - 2013
Overexpression of the tyrosine kinase receptor ErbB2/HER2/Neu, occurs in 25% to 30% of invasive breast cancer (BC) with poor patient prognosis. Even if numerous studies have shown prevention of breast cancer by n-3 fatty acid intake, the experimental conditions under which n-3 fatty acids exert their protective effect have been ...
Lin Jia-Ni - - 2013
Yellow camellia, with its golden-yellow flowers, is rare in the world. Most studies of yellow camellia have focused on its ornamental properties; however, there were fewer published studies on its medical values. The purpose of this study was to define the chemical constituents and the biological potential of the water ...
Vyry Wouatsa N A - - 2013
From the extract of Zanthoxylum zanthoxyloides fruits, a new menthane monoterpenoid, (4R,7R)-8-carboxy-7,9-dihydroxy-trans-menthane, tentatively, named as zantholic acid along with several known compounds was isolated. Its structure was determined using spectroscopic methods. The cytotoxic activity of zantholic acid against a panel of cancer cell lines was evaluated using the MTT assay. ...
Dankers Anita C A - - 2013
Hyperuricemia is related to a variety of pathologies, including chronic kidney disease (CKD). However, the pathophysiological mechanisms underlying disease development are not yet fully elucidated. Here, we studied the effect of hyperuricemia on tryptophan metabolism and the potential role herein of two important uric acid efflux transporters, multidrug resistance protein ...
Saphier Oshra - - 2013
We conducted this study to determine the fatty acid composition of breastmilk of Israeli women and compare it with baby milk substitutes. Samples of mature breast milk, from 29 lactating Israeli Jewish mothers were collected during feedings. Total milk lipids extracts were transmethylated and analysed by using an improved gas-chromatographic ...
Szlagatys-Sidorkiewicz Agnieszka - - 2013
AIM: We hypothesized that the fatty acid composition of breast milk can be affected by a smoking habit in the mother. Consequently, this study verified whether maternal smoking modulates, and if so to what extent, the breast milk fatty acid profile. METHODS: The study included 20 postpartum women who declared ...
Nishimura Renata Y - - 2013
OBJECTIVES: To evaluate the fatty acid composition of mature human milk of women living far from the coastal area of Brazil. METHODS: Mature breast milk samples were obtained from 47 lactating women aged between 18 and 35 years, who delivered their babies at term and who exclusively or predominantly breastfed. ...
Okruszek A - - 2013
The aim of the study was to compare the chemical and amino acid composition of breast (pectoralis major) and thigh (biceps femoris) muscles in 17-wk-old geese from 2 Polish conservative flocks: Rypińska (Ry, n = 20) and Garbonosa (Ga, n = 20). The geese were fed ad libitum during the ...
Silberstein Tali - - 2013
Breast milk is well established as the ideal source of nutrition for infants. Mature human breast milk generally contains 3.5-4.5% lipids comprising mostly triacylglycerols. In general, the fat composition of maternal human milk in developing countries shows higher levels of saturated fats, reflecting diets rich in carbohydrates. To determine the ...
Jetson Rachael R Center for Drug Design and Development, Department of Medicinal and Biological Chemistry, College of Pharmacy and Pharmaceutical Sciences, University of Toledo, Toledo, OH 43606, - - 2013
Retinoic acid receptor alpha (RARα) selective compounds may guide the design of drugs that can be used in conjunction with hormonal adjuvant therapy in the treatment of breast cancer. Herein we report a modified synthesis of a known RARα antagonist, 2-fluoro-4-[[[8-bromo-2,2-dimethyl-4-(4-methylphenyl)chroman-6-yl]carbonyl]amino]benzoic acid and a synthesis of its unknown, desfluoro analog, ...
Kamboh A A - - 2013
This study was conducted to investigate the supplemental effects of purified bioflavonoids (genistein and hesperidin), as potential alternatives to plant/herbs or synthetic antioxidants, individually and in combination for fatty acid profile, lipid metabolites, and antioxidant status of broilers. Three hundred sixty 1-d-old broilers were divided into 6 treatment groups: control ...
Busnena Belnaser A - - 2013
(-)-Oleocanthal (1) and ligstroside aglycone (2) are common bioactive olive oil secoiridoids. Secoiridoid 1 has been previously reported as a c-MET inhibitor. Chemically, (-)-oleocanthal is the elenolic acid ester of the common olive phenolic alcohol tyrosol. Therefore, several analogues (4-13) were synthesized by esterification and carbamoylation of tyrosol using diverse ...
Gazvoda Martin - - 2013
The aldo-keto reductase AKR1C3 is an important target for the development of new drugs. Selective inhibitors of this enzyme are needed because they should not inhibit other, structurally closely related AKR1C isoforms. A comprehensive series of 2,3-diarylpropenoic acids was synthesized and evaluated for the inhibition of AKR1C1-AKR1C3. We found that the ...
Białek Agnieszka - - 2013
Cancers are the second leading cause of deaths in Poland, among both women and men. Breast cancer is the malignancy most frequently diagnosed in women. In 2008 mammary cancer was diagnosed in up to 14 500 patients. It is also the second most common cause of cancer deaths among women ...
Hawas Usama W - - 2013
A new naturally occurring compound based on the dammarane skeleton, i.e. cabralealactone 3-acetate-24-methyl ether, was isolated from the aqueous methanolic extract of Forsythia koreana fruits, along with eight known compounds: cabralealactone 3-acetate, ursolic acid, arctigenin, arctiin, phillyrin, rutin, caffeic acid, and rosmarinic acid. The identification of the isolated compounds was ...
Shibuya Ayako - - 2013
While breast milk has been known as a cause of neonatal hyperbilirubinemia, the underlying mechanism of breast milk-induced jaundice has not been clarified. Here, the impact of fatty acids on human UDP-glucuronosyltransferase (UGT) 1A1 - the sole enzyme that can metabolize bilirubin - were examined. Oleic acid, linoleic acid, and ...
Tan Kee W - - 2013
Breast cancer resistance protein (BCRP/ABCG2) plays an important role in determining the absorption and disposition of consumed xenobiotics including various drugs and dietary phytochemicals and is also one of the prominent efflux transporters involved in multidrug resistance (MDR). In this study, we have investigated the interactions between ABCG2 and 56 ...
Vasskog Terje - - 2012
The marine opisthobranch Scaphander lignarius has been analyzed in the systematic search for novel bioactive compounds in Arctic marine organisms using bioassay guided fractionation. A number of highly cytotoxic fractions were shown to contain mainly polyunsaturated fatty acids (PUFAs). Selected PUFAs were isolated and identified using both liquid chromatography-mass spectrometry ...
Azordegan Nazila - - 2012
Cancerogenesis is associated with cell membrane changes. The aim of this study was to investigate whether breast tissues with different degrees of cancer involvement have different fatty acid profiles. Fourteen breast cancer patients with a mean age of 61 years were recruited. Morphological features of the tumoral specimens were characterized. Approximately ...
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