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Boyce Malcolm M Hammersmith Medicines Research, Central Middlesex Hospital, London NW10 7NS, - - 2014
To compare gastric acid suppression by netazepide, a gastrin/CCK2 receptor antagonist, with that by a proton pump inhibitor (PPI), and to determine if netazepide can prevent the trophic effects of PPI-induced hypergastrinaemia. Thirty healthy subjects completed a double-blind, randomised, parallel-group trial of oral netazepide and rabeprazole, alone and combined, once ...
Martins José Luís Rodrigues JL Institute of Biological Sciences, Department of Physiological Sciences, Federal University of Goiás, Campus Samambaia, Goiânia-GO, - - 2014
Celtis iguanaea (Canabaceae) is popularly known as esporão-de-galo, stands out among the medicinal plants used for treatment of gastric ulcers. In Brazil, the leaves they are used traditionally in infusion forms as an analgesic, antiasthmatic, digestive and diuretic. The present study was aimed to investigate the antiulcer mechanisms of hexane ...
Pasaribu Buntora B Graduate Institute of Biotechnology, National Chung-Hsing University, Taichung 402, - - 2014
Numerous oil bodies of 0.2-2 μm occupied approximately 80% of intracellular space in mature pine (Pinus massoniana) megagametophytes. They were stably isolated and found to comprise mostly triacylglycerols as examined by thin layer chromatography analysis and confirmed by both Nile red and BODIPY stainings. Fatty acids released from the triacylglycerols of ...
de La Torre Aurélien A Institut des Biomolécules Max Mousseron (IBMM) UMR CNRS 5247-Universités de Montpellier I et II, ENSCM, Faculté de Pharmacie, 15 Av. Charles Flahault, 34093 Montpellier cedex 05 - - 2014
The growing importance of lipidomics, and the interest of non-enzymatic metabolites of polyunsaturated fatty acids (PUFAs) prompted us to initiate the synthesis of novel dihomo-IsoF compounds. Such metabolites of adrenic acid, the main PUFA in white matter, were synthesized using a divergent approach based on an orthoester cyclization. LC-MS/MS investigation ...
Dayaker Gandrath - - 2014
The first total synthesis of three omega-6 dihydroxylated E,E,Z-docosatrienes has been successfully achieved employing a flexible strategy. The key features of which encompass a Boland semi-reduction, to create the E,E,Z-triene via a E,E-ynediene, and a selective deprotection of a tri(tert-butyl)dimethylsilylether. The main advantage of the present strategy over previous syntheses ...
Al Hosani H H Central Department of Maternal and Child Health, Ministry of Health, Abu Dhabi, United Arab - - 2014
The national neonatal screening programme in the United Arab Emirates currently includes 16 disorders: congenital hypothyroidism, sickle-cell diseases, congenital adrenal hyperplasia, biotinidase deficiency and 12 amino acid, organic acid and fatty acid disorders. This paper reports data since the programme started in January 1995 up to December 2011 on the ...
Scaini Giselli G Laboratório de Bioenergética, Programa de Pós-Graduação em Ciências da Saúde, Universidade do Extremo Sul Catarinense Criciúma, Av. UniversitÄria, 1105, Criciúma, 88806-000, SC, - - 2014
Maple syrup urine disease (MSUD) is an inborn metabolism error caused by a deficiency of branched-chain α-keto acid dehydrogenase complex activity. This blockage leads to an accumulation of the branched-chain amino acids (BCAA) leucine, isoleucine, and valine, as well as their corresponding α-keto and α-hydroxy acids. Previous reports suggest that ...
Park Hee Dong - - 2013
Adrenomyeloneuropathy (AMN), one of the variants of X-linked adrenoleukodystrophy (ALD), is inherited peroxisomal disorder associated with the accumulation of very long chain fatty acids (VLCFA). AMN is characterized primarily by involvements of long ascending and descending tracts of the spinal cord and peripheral neuropathy, which leads to spastic paraparesis and ...
Sumich Alex L - - 2013
Atypical fatty acid metabolism has been reported in attention deficit hyperactivity disorder (ADHD), however, its relationship with temperament in this population is unclear. The current study investigated the association between blood levels of fatty acids implicated in brain structure and function (omega-3, omega-6, omega-9) and personality traits of stability (neuroticism, ...
López-Erauskin Jone - - 2013
Abstract X-linked adrenoleukodystrophy (X-ALD) is a severe inherited neurodegenerative disorder characterized by adrenal insufficiency and graded damage in the nervous system. Loss of function of the peroxisomal ABCD1 fatty-acid transporter, resulting in the accumulation in organs and plasma of very long-chain fatty acids, is the genetic cause. Treatment with a ...
Wang Chiung-Min - - 2013
Steroidogenic factor 1 (NR5A1/SF1) is a well-known master regulator in controlling adrenal and sexual development, as well as regulating numerous genes involved in adrenal and gonadal steroidogenesis. Several studies including ours have demonstrated that NR5A1 can be SUMOylated on lysine 194 (K194, the major site) and lysine 119 (K119, the ...
Baptista Miguel - - 2011
The objectives of the present work were to investigate the temporal variation in the fatty acid (FA) composition of the octocoral Veretillum cynomorium, examine the effects of reproduction and environmental factors on FA variation, and establish a chemotaxonomic identification for this species. Mean oocyte size-frequency distributions showed that the majority ...
Berenhauser Ana Claudia - - 2011
The aim of this study was to determine and compare the fatty acid (FA) composition of colostrum and mature milk produced by nursing mothers of preterm and at-term newborns, in Florianópolis, SC, Brazil. Low contents of Eicosapentaenoic acid (EPA) (0.02%/colostrum and 0.01%/mature milk for preterm and term milk) and Docosahexaenoic ...
Yeni D - - 2011
The aim of this study was to investigate the effect of alpha lipoic acid (ALA, an universal antioxidant) on thinner-induced testicular toxicity regarding spermatological features, body and reproductive tract measures in rats. Adult male Sprague-Dawley rats were divided into five treatment groups, eight rats in each. Control group was treated ...
Miyata Shinji - - 2011
Naturally occurring polysialic acid (polySia) structures have a large diversity, primarily arising from the diversity in the sialic acid components as well as in the intersialyl linkages. In 2004, we demonstrated the presence of a new type of polySia, 8-O-sulfated N-acetylneuraminic acid (Neu5Ac) capped α2,9-linked polyNeu5Ac, on the O-glycans of ...
Van Hoeck Veerle V Laboratory for Veterinary Physiology and Biochemistry, Department of Veterinary Sciences, Faculty of Biomedical, Pharmaceutical and Veterinary Sciences, University of Antwerp, Wilrijk, Belgium. - - 2011
Elevated concentrations of serum non-esterified fatty acids (NEFA), associated with maternal disorders such as obesity and type II diabetes, alter the ovarian follicular micro-environment and have been associated with subfertility arising from reduced oocyte developmental competence. We have asked whether elevated NEFA concentrations during oocyte maturation affect the development and ...
Taylor Matthew J W - - 2010
In recent years, copper-catalyzed atom transfer radical addition (ATRA) has emerged as a viable organic procedure for the formation of carbon-carbon bonds starting from alkyl halides and alkenes. Studies have primarily focused on the use of free-radical initiators to regenerate the copper(I) complex or activator in situ. Although these initiators ...
Xia Cao - - 2011
Cu(4)(OH)(6)SO(4) (brochantite) is an undesirable oxidation product of copper-bearing sulfides, and it is seldom considered to be biologically and electrochemically active. In this paper, we report that Cu(4)(OH)(6)SO(4) nanoparticles in fact possess an intrinsic electrocatalytic activity, which is explored as a biosensing material to oxidize l-ascorbic acid (AA). The Cu(4)(OH)(6)SO(4) ...
Joubert Elizabeth E Agricultural Research Council (ARC) Infruitec-Nietvoorbij, Private Bag X5026, Stellenbosch 7599, South - - 2010
Heat-induced changes in aspalathin, iso-orientin, and orientin content of ready-to-drink (RTD) green rooibos iced tea formulations were investigated. An organic-solvent-based aspalathin-enriched extract prepared from green rooibos was used "as-is" or encapsulated with ascorbic acid in a water-soluble nanomicelle-based carrier system. The common iced tea ingredients, ascorbic acid, and/or citric acid ...
Plotto Anne - - 2010
Edible coatings may extend fresh-cut fruit storage by preventing moisture loss and decreasing gas exchange. This study evaluated the effect of an antibrowning dip (calcium ascorbate, citric acid and N-acetyl-L-cysteine), followed or not with carboxymethylcellulose (CMC) or carrageenan coatings on quality of fresh-cut mangoes stored at 5 °C for up ...
Donpunha Wanida - - 2011
Cadmium (Cd) is one of the most important environmental pollutants that cause a number of adverse health effects in humans and animals. Recent studies have shown that Cd-induced oxidative damage within the vascular tissues results in vascular dysfunction. The current study was aimed to investigate whether ascorbic acid could protect ...
Qin Aiguo - - 2011
Ascorbic acid (AsA, vitamin C) is one of the most important nutritional quality factors in many horticultural crops and has many biological activities in the human body. Dehydroascorbate reductase (EC 1.8.5.1; DHAR) plays an important role in maintaining the normal level of ascorbic acid (AsA) by recycling oxidized ascorbic acid. ...
Arenas Leliz T - - 2010
A film of niobium oxide was immobilized on a SiO(2)/C carbon-ceramic matrix (specific surface area 270 m(2)g(-1)) and characterized by N(2) adsorption-desorption isotherms, scanning electron microscopy, X-ray photoelectron spectroscopy and atomic force microscopy. This new carbon-ceramic material, SiO(2)/C/Nb(2)O(5), was used for construction of electrodes, and it shows ability to improve ...
Mohamed Hasab E - - 2011
There is suggestive evidence that a low status of ascorbic acid in camels enhances their risk for infectious diseases. This study was carried out to disclose the role of reproduction, if any, in affecting ascorbic acid status. The associations between the reproductive cycle and ascorbic acid contents in plasma and ...
Pecivová Pavlína - - 2010
The effects of mixtures of reducing and oxidising agents on the rheological characteristics and quality of wheat flour dough and the sensory characteristics of buns were studied. In chemical analyses, no differences between control dough and doughs with individual mixtures of additives were found. Rheological measurements showed that increasing addition ...
Sezgintürk Mustafa Kemal - - 2010
An amperometric biosensor based on zucchini (Cucurbita pepo) tissue homogenate is presented. The zucchini tissue homogenate was crosslinked with gelatine using glutaraldehyde and fixed on a pretreated teflon membrane. The zucchini tissue contained the enzyme ascorbate oxidase and this enzyme catalyzed the oxidation of ascorbic acid in the presence of ...
Son Kyung Mi - - 2010
Biomimetic apatite coating has been used to load osteogenic biomolecules onto the surface of titanium implants. Apatite on the surface of biomaterials is thought to function as a reservoir of biomolecules as well as enhancing osteoconductivity. In this study, 20alpha-hydroxycholesterol (20alpha-HC), an osteogenic oxysterol, was used to induce differentiation of ...
Fathi-Azarbayjani Anahita - - 2010
L-ascorbic acid has been widely used in cosmetic and dermatological products because of its ability to scavenge free radicals and destroy oxidizing agents. However, it is chemically unstable and can easily be oxidized. The current cosmetic facial masks available in the market are pre-moistened, which means that the aqueous fluid ...
Viry Lucie - - 2010
The detection of dopamine is a scientific challenge of great importance for the understanding of neurobiological dysfunctions. However the presence of ascorbic acid at concentrations several times higher than that of dopamine and its oxidation at a very similar potential make a selective electrochemical detection difficult. Here we report the ...
Malebane Ingrid M - - 2010
Two experiments were carried out to determine the effect of dietary ascorbic acid supplementation levels on productivity, carcass characteristics, and mortality of indigenous Venda chickens. The first experiment determined the effect of dietary ascorbic acid supplementation levels on productivity and mortality rate of 175 unsexed Venda chickens between 1 and ...
Pons Alexandre - - 2010
Sotolon (3-hydroxy-4,5-dimethyl-2(5H)-furanone) is a chiral furanone, an aroma compound known to be responsible for premature-aging flavor in dry white wines. Sotolon generally results from mild oxygenation during bottle aging, and until now, its formation pathways had not been elucidated. The ability of the main precursors described in the literature under ...
Tai Akihiro - - 2010
A stable ascorbic acid derivative, 2-O-alpha-D-glucopyranosyl-L-ascorbic acid (AA-2G), exhibits vitamin C activity in vitro and in vivo after enzymatic hydrolysis to ascorbic acid. AA-2G has been approved by the Japanese Government as a quasi-drug principal ingredient in skin care and as a food additive. In order to achieve efficient action ...
Temu Tecla M TM Department of Pediatrics, Division of Pediatric Endocrinology and Metabolism, Rhode Island Hospital and Brown University, 593 Eddy Street, Providence, RI 02903, - - 2010
The ATDC5 cell line exhibits a multistep process of chondrogenic differentiation analogous to that observed during endochondral bone formation. Previous investigators have induced ATDC5 cells to differentiate by exposing them to insulin at high concentrations. We have observed spontaneous differentiation of ATDC5 cells maintained in ascorbic acid-containing alpha-MEM. A comparison ...
Narayana Kilarkaje - - 2010
The ability of cisplatin (cis-diaminedichloroplatinum-II) to induce DNA double-strand breaks and expression of p53, Bax and Bcl-2 and possible protective effects of L-ascorbic acid was investigated in epididymis. Adult BALB/C mice were treated (ip) as follows: group I-- control; group II--L-ascorbic acid (10 mg/kg); group III--two cycles of 5 days ...
Timpson Nicholas J NJ Medical Research Council Centre for Causal Analyses in Translational Epidemiology, University of Bristol, Department of Social Medicine, Oakfield House, Oakfield Grove, Bristol, BS8 2BN, United Kingdom. - - 2010
L-ascorbic acid is an essential part of the human diet and has been associated with a wide range of chronic complex diseases, including cardiovascular outcomes. To date, there are no confirmed genetic correlates of circulating concentrations of L-ascorbic acid. We aimed to confirm the existence of an association between common ...
Ruiz-Ramos M - - 2010
OBJECTIVE: To determine the effect of ascorbic acid and alpha-tocopherol on oxidative stress and bone mineral density (BMD) in elderly people. DESIGN: A double-blind, controlled clinical assay was carried out in a sample of 90 elderly subjects divided into three age-paired random groups with 30 subjects in each group. Group ...
Black Homer S - - 2010
Epidemiological studies suggested that above average intake of beta-carotene (betaC) might reduce cancer risks. However, clinical trials found that betaC supplementation did not reduce the occurrence of non-melanoma skin cancer and that smokers suffered a significant increase in lung cancer incidence. Further, supplementing semi-defined diets with betaC failed to provide ...
Liu Lei - - 2010
Ascorbic acid has important antioxidant properties, and may play a role in the protective effects of ischemic preconditioning on later ischemia-reperfusion. Herein, we examined the role of endogenous extracellular ascorbic acid in ischemic preconditioning in the kidney. We developed a solitary rabbit kidney model where animals received ischemia-reperfusion only (ischemia-reperfusion ...
Ghosh Srabanti - - 2010
The gamma irradiation method has provided a route for synthesis of highly water-soluble, good-quality luminescent CdS/dendrimer nanocomposites with amino- or carboxyl-terminated PAMAM dendrimer. An attempt has been made to probe ascorbic acid with the as-synthesized CdS/dendrimer nanocomposites (DNC). Ascorbic acid (AA) is an important biological antioxidant and marker for different ...
Tomé Adriana da Rocha Ada - - 2010
Temporal lobe epilepsy is the most common form of epilepsy in humans. Oxidative stress is a mechanism of cell death induced by seizures. Antioxidant compounds have neuroprotective effects due to their ability to inhibit free radical production. The objectives of this work were to comparatively study the inhibitory action of ...
Corti Alessandro - - 2010
The mechanisms allowing the cellular transport of ascorbic acid represent a primary aspect for the understanding of the roles played by this vitamin in pathophysiology. Considerable research effort has been spent in the field, on several animal models and different cell types. Several mechanisms have been described to date, mediating ...
Reidling Jack C JC VA Medical Center, Long Beach, CA 90822, USA. - - 2011
Ascorbic acid, the active form of vitamin C, is a vital antioxidant in the human liver, yet the molecular mechanisms involved in the regulation of ascorbic acid transporters [human sodium-dependent vitamin C transporters (hSVCT) 1 and 2] in liver cells are poorly understood. Therefore, we characterized the minimal promoter regions ...
Seifi Hesam A - - 2010
The objectives of the present study were to investigate effects of over-supplementation of ascorbic acid on hematology, serum biochemistry and weight gain in Holstein dairy calves. A total of 90 Holstein dairy calves were randomly assigned to receive one of two treatments. Ascorbic acid was administered orally to treatment group ...
Tai Akihiro - - 2010
2-O-alpha-D-Glucopyranosyl-L-ascorbic acid (AA-2G) laurate was synthesized from AA-2G and vinyl laurate with a protease from Bacillus subtilis in N,N-dimethylformamide (DMF) with low water content. Addition of water to DMF dramatically enhanced monoacyl AA-2G synthesis. Maximum synthetic activity was observed when 3% (v/v) water was added to the reaction medium. Under ...
Zhang Yuanfu - - 2010
An approach for visual sensing of ascorbic acid is presented. This method is based on the distance-dependent optical property of gold nanoparticles and the Cu(+)-catalyzed alkyne-azide click reaction. We prepared the terminal azide- and alkyne-functionalized gold nanoparticle probes. In the presence of Cu(2+), ascorbic acid could rapidly induce the aggregation ...
Hu Jian-Hong - - 2010
To investigate the effects of ascorbic acid supplementation on standard semen quality parameters and antioxidant activities after thawing of bovine frozen semen, antioxidant ascorbic acid was added at concentrations of 2.5, 4.5, 6.5 and 8.5 mg/ml to bovine semen cryoprotective medium. The results showed that the sperm motility and motion ...
Oluwafemi Oluwatobi S - - 2010
A simple, green room temperature synthesis of ascorbic acid-capped ZnSe nanoparticles is hereby reported. By varying the pH of the solution, the temporal evolution of the optical properties and shape of the nanocrystals was investigated. The nanoparticles were characterized by UV-vis absorption and photoluminescence spectroscopy (PL), transmission electron microscope (TEM) ...
Mohammad Amani - - 2010
Extended exposure to low levels of lead causes high blood pressure in human and laboratory animals. The mechanism is not completely recognized, but it is relatively implicated with generation of free radicals, oxidant agents such as ROS, and decrease of available nitric oxide (NO). In this study, we have demonstrated ...
Singh Sohini - - 2010
Arsenic is an ubiquitous and well-documented carcinogenic metalloid. The most common source of arsenic is drinking water. The mechanism of arsenic toxicity in a cell has historically been centered around its inhibitory effects on cellular respiration and mitochondrial injury. Ascorbic acid, a low molecular weight, water-soluble antioxidant, improves the reduced ...
Matsumoto Shigekiyo - - 2010
Electron spin resonance (ESR)-silent ascorbate solutions generate a detectable, likely concentration-dependent signal of ascorbyl free radicals (AFR) immediately upon addition of a molar excess of dimethyl sulfoxide (DMSO). We aimed to perform quantitative ESR analysis of AFR in real time after addition of DMSO (AFR/DMSO) to evaluate ascorbate concentrations in ...
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