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Naeimi Hossein H Department of Organic Chemistry, Faculty of Chemistry, University of Kashan, Kashan, 87317, IR Iran. - - 2014
Regarding green chemistry goals, silica-coated magnetite nanoparticles open up a new avenue to introduce a very useful and efficient system for facilitating catalyst recovery in different organic reactions. Therefore, in this paper the preparation of sulfonic acid-functionalized silica-coated magnetic nanoparticles with core-shell structure (Fe3O4@silica sulfonic acid) is presented by using ...
Zaima Nobuhiro N Department of Applied Biological Chemistry, Graduate School of Agriculture, Kinki University, Nara, 631-8505, - - 2014
Sake is made from fermented rice and has been drunk in Japan for more than 1000 years. The rice must be polished prior to fermentation to obtain high-quality sake. It is traditionally recognized that the quality of sake is improved as the rice polishing ratio (percentage removed in the polishing ...
Fouetio Kengne Blaise-Alexis - - 2014
Self-assembled monolayers (SAMs) of thiols, of L-cysteine, 6-mercaptohexanol, 4-mercaptobenzoic acid, DL-thioctic acid and 11-(1-pyrenyl)-1-undecathiol, which have been selected for their propensity to interact with vaporized explosives, have been attached from solution onto gold decorated ZnO-coated nanosprings. X-ray and ultraviolet photoelectron spectroscopies (XPS and UPS) have been used to investigate the ...
Granger Brett A BA Department of Chemistry, The University of Texas at Austin, 1 University Station A5300, Austin, Texas 78712-0165, - - 2014
A concise total synthesis of the complex indole alkaloid (±)-actinophyllic acid was accomplished by a sequence of reactions requiring only 10 steps from readily-available, known starting materials. The approach featured a Lewis acid-catalyzed cascade of reactions involving stabilized carbocations that delivered the tetracyclic core of the natural product in a ...
Wang Lifang L State Key Laboratory of Environmental Geochemistry, Institute of Geochemistry, Chinese Academy of Sciences, 550002, Guiyang, - - 2014
Lakes Dianchi (DC) and Bosten (BST) were determined to be at different stages of eutrophication, by use of total organic carbon content, bulk carbon isotopic composition, bulk nitrogen isotopic composition, and bound saturated fatty acid (BSFA) concentrations in sediment cores. A rapid increase in the supply of organic matter (OM) ...
Banga Resham J RJ International Institute of Nanotechnology, ‡Department of Chemical and Biological Engineering, §Department of Chemistry, and ⊥Department of Biomedical Engineering, Northwestern University , 2145 Sheridan Road, Evanston, Illinois 60208, United - - 2014
A novel class of metal-free spherical nucleic acid nanostructures was synthesized from readily available starting components. These particles consist of 30 nm liposomal cores, composed of an FDA-approved 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) lipid monomer. The surface of the liposomes was functionalized with DNA strands modified with a tocopherol tail that intercalates into ...
Wanangkarn Amornrat A Department of Agricultural Science, Naresuan University, Phitsanulok 65000, - - 2014
This study applied restriction fragment length polymorphism (RFLP) analysis to identify the lactic acid bacteria (LAB) isolated from "mum" Thai fermented sausages during fermentation and storage. A total of 630 lactic acid bacteria were isolated from the sausages prepared using 2 methods. In Method 1, after stuffing, the sausages were ...
Handy Emma L EL Department of Chemistry, Brown University , 324 Brook Street, Providence, Rhode Island 02912, United - - 2014
Peptides containing N2-acyl piperazic or 1,6-dehydropiperazic acids can be formed efficiently via a novel multicomponent reaction of 1,4,5,6-tetrahydropyridazines, isocyanides, and carboxylic acids. Remarkably, the reaction's induced intramolecularity can enable the regiospecific formation of products with N2-acyl piperazic acid, which counters the intrinsic and troublesome propensity for piperazic acids to react ...
Bui Thanh-Huong TH Institute of Pharmacy, Department of Pharmaceutical Biology, Ernst-Moritz-Arndt-University , Friedrich-Ludwig-Jahn-Straße 17, D-17489 Greifswald, - - 2014
Balticidins A-D (1-4), four new antifungal lipopeptides, were isolated from the laboratory-cultivated cyanobacterium Anabaena cylindrica strain Bio33 isolated from a water sample collected from the Baltic Sea, Rügen Island, Germany. Fractionation of the 50% aqueous MeOH extract was performed by bioassay-guided silica gel column chromatography followed by SPE and repeated ...
Matera Riccardo R R&D Division, BeC S.r.l., Via C. Monteverdi 49, 47122 Forlì, - - 2015
Little is known on structure-activity relationships of antioxidant anthocyanins. Raphanus sativus cv Sango sprouts are among the richest sources (270mg/100g fresh weight). We isolated from sprouts' juice 9 acylated anthocyanins, including 4 new compounds. All comprise a cyanidin core bearing 3-4 glucose units, multiply acylated with malonic and phenolic acids ...
Bernhardt Harold S HS Department of Biochemistry, University of Otago, PO Box 56, Dunedin, 9054, New Zealand, - - 2014
We propose that glycine was the first amino acid to be incorporated into the genetic code, followed by serine, aspartic and/or glutamic acid-small hydrophilic amino acids that all have codons in the bottom right-hand corner of the standard genetic code table. Because primordial ribosomal synthesis is presumed to have been ...
Labarre-Lainé Jessica J University of Bordeaux, 351, Cours de la libération, 33405 Talence Cedex (France), Fax: - - 2014
Synthesis of the bis-spiroacetal core of 13-desmethyl spirolide C has been completed based on a sila-Stetter-acetalization process. The acylsilane and enone partners in the Stetter reaction were prepared in 7 and 11 steps, respectively, from (S) and (R)-aspartic acid. The quaternary center at C19 in the enone moiety was controlled by ...
Zhang Ling - - 2014
Convex hexoctahedral nanocrystals have been synthesized through fast growth kinetics and the use of cetylpyridinium chloride as a capping agent. Monodisperse convex hexoctahedral Pd@Au core-shell nanocrystals with {431} high-index facets are obtained at high reaction rates by using high concentrations of ascorbic acid in the presence of cetylpyridinium chloride. In ...
Julich-Gruner Konstanze K KK Department of Chemistry, Technische Universität Dresden, Bergstrasse 66, 01069 Dresden (Germany), Fax: - - 2014
The boronic acid-catalyzed annulation of citral opens up a short route to oxygenated cyclized monoterpenoid pyranocarbazole alkaloids. Thus, murrayamine-D is available in only three steps and 55% overall yield from the corresponding carbazole precursor.
Pett Christian C Gesellschaft zur Förderung der Analytischen Wissenschaften e.V. ISAS, Leibniz Institute for Analytical Sciences, Otto-Hahn-Str. 6b, 44227 Dortmund - - 2014
Mucins are a class of highly O-glycosylated proteins found on the surface of cells in epithelial tissues. O-Glycosylation is crucial for the functionality of mucins and changes therein can have severe consequences for an organism. With that in mind, the elucidation of interactions of carbohydrate binding proteins with mucins, whether ...
Jeong Yong-Chul YC Chemistry Research Laboratory, University of Oxford, Mansfield Rd, Oxford, OX1 3TA - - 2014
Inspired by the core fragment of antibacterial natural products such as streptolydigin, 3-acyltetramic acids and 3-acylpiperidine-2,4-diones have been synthesised from the core heterocycle by direct acylation with the substituted carboxylic acids using a strategy which permits ready access to a structurally diverse compound library. The antibacterial activity of these systems ...
Quast Isaak I Institute of Experimental Immunology, Department of Neuroinflammation, University of Zurich, Winterthurerstrasse 190, Zurich, - - 2014
Immunoglobulin G (IgG) molecules are glycoproteins and residues in the sugar moiety attached to the IgG constant fragment (Fc) are essential for IgG functionality such as binding to cellular Fc receptors and complement activation. The core of this sugar moiety consists of a bi-antennary heptameric structure of mannose and N-acetylglucosamine ...
Tapia Rubén - - 2014
The first synthesis of spiro lactone (+)-vitedoin B (14 steps, 8.0 % global yield) and spiro enol ether (+)-negundoin A (19 steps, 3.7 % global yield), via a nor-labdane acetoxy ester, has been achieved starting from commercial (+)-abietic acid.
Torricelli Fabio Cesar Miranda FC Stevan B. Streem Center for Endourology and Stone Disease, Glickman Urological & Kidney Institute, The Cleveland Clinic, Cleveland, OH; Division of Urology, Hospital das Clinicas, University of Sao Paulo Medical School, São Paulo, São Paulo, - - 2014
To study several measurements from a single-energy noncontrast computed tomography (NCCT) that may distinguish calcium oxalate, uric acid, and cystine stones. Patients with pure urinary stones who had at least 1 single-energy NCCT before the stone composition analysis from January 2008 to December 2012 were enrolled in this study. The ...
Silveira-Dorta Gaston - - 2014
Enantiomerically pure anti-β-amino alcohols were synthesized from optically pure alpha-N,N-dibenzylamino benzyl esters, derived from alpha-amino acids, by the sequential reduction to aldehyde with DIBAL-H at -78 °C, and subsequent in situ addition of Grignard reagents. Besides anti-β-amino alcohols, anti-2-amino-1,3-diols, and anti-3-amino-1,4-diols, in good yields (60-95%) and excellent stereoselectivity (de > ...
Li Hongmei - - 2014
A synthetic method to prepare a core-shell-structured Fe3O4@SiO2 as a safe nanovehicle for tumor cell targeting has been developed. Superparamagnetic iron oxide is encapsulated inside nonporous silica as the core to provide magnetic targeting. Carboxymethyl chitosan-folic acid (OCMCS-FA) synthesized through coupling folic acid (FA) with OCMCS is then covalently linked ...
Ouchi Hitoshi H School of Pharmaceutical Sciences, University of Shizuoka , 52-1 Yada, Suruga-ku, Shizuoka 422-8526, - - 2014
Practical total syntheses of acromelic acids A (1) and B (2), which have potent neuro-excitatory activity, were accomplished in 13 (36% total yield) and 17 steps (6.9% total yield), respectively, from 2,6-dichloropyridine (8). Regioselective transformation of symmetric 8 provided nitroalkenes 15 and 16. The pyrrolidine ring was efficiently constructed by ...
Palusiak Agata A Department of General Microbiology, Institute of Microbiology, Biotechnology and Immunology, University of Łódź, Łódź, - - 2014
Most Proteus lipopolysaccharides (LPSs) contain uronic acids or their amides with different amino acids, which together with other negatively charged components account for the acidic character of such LPS molecules. Previous studies have shown the significance of an amide of galacturonic acid with lysine [D-GalA(L-Lys)] for serological specificity of O-antigens ...
Pokorny Barbara B Department of Chemistry, University of Natural Resources and Life Sciences, Muthgasse 18, A-1190 Vienna, - - 2014
The α-d-glucopyranosyl-(1→5)-substituted methyl glycosides of 3-deoxy-α-d-manno-oct-2-ulosonic acid (Kdo), 3-deoxy-α-d-lyxo-hept-2-ulosonic acid (Kdh), and d-glycero-α-d-talo-oct-2-ulosonic acid (Ko) were prepared using orthogonally protected glycosyl acceptor derivatives via glycosylation with a torsionally disarmed 4,6-O-benzylidene protected trifluoroacetimidate glucosyl donor followed by global deprotection. The related 6-O-phosphoryl-α-d-glucopyranosyl-(1→5)-substituted Kdo and Kdh derivatives were derived from a benzylidene-protected ...
Abbasov Mikail E - - 2014
α,β-Unsaturated acylammonium salts, generated in situ from commodity acid chlorides and a chiral isothiourea organocatalyst, comprise a new and versatile family of chiral dienophiles for the venerable Diels-Alder cycloaddition. Their reactivity is unveiled through a highly diastereo- and enantioselective Diels-Alder-lactonization organocascade that generates cis- and trans-fused bicyclic γ- and δ-lactones ...
Luu Stephanie S Department of Molecular Biology and Biophysics, University of Connecticut Health Center, Farmington, Connecticut, - - 2014
A major event in the nutrient germination of spores of Bacillus species is release of the spores' large depot of dipicolinic acid (DPA). This event is preceded by both commitment, in which spores continue through germination even if germinants are removed, and loss of spore heat resistance. The latter event ...
Pulido Daniel D Combinatorial Chemistry Unit, Barcelona Science Park , 08028 Barcelona, - - 2014
A highly versatile synthetic strategy is described to generate multimodal and multivalent platforms based on a diethylenetriaminepentaacetic (DTPA) core. Compounds with different functionalization patterns, from mono- to pentamodal, have been prepared using robust and simple chemistry.
Qin Tian T Department of Chemistry and Center for Chemical Methodology and Library Development (CMLD-BU), Boston University, 590 Commonwealth Avenue, Boston, MA 02215 - - 2014
Total syntheses of the dimeric tetrahydroxanthone natural products secalonic acids A and D are described. Key steps involve kinetic resolution of the tetrahydroxanthone core structure using homobenzotetramisole catalysis and late-stage copper(I)-mediated homodimerization of complex aryl stannane monomers.
Lelle Marco M Max Planck Institute for Polymer Research, Ackermannweg 10, 55128, Mainz, - - 2014
We describe the synthesis and characterization of a new lysine-based heterofunctional cross-linking reagent. It carries two readily available aminooxy functionalities and an activated and protected thiol group that is capable of generating reducible disulfides, the former enable bioorthogonal modification of ketones and aldehydes by the formation of an oxime bond. ...
Soto-Cerda Braulio J BJ Department of Plant Science, University of Manitoba, 66 Dafoe Road, Winnipeg, MB, R3T 2N2, - - 2014
The identification of stable QTL for seed quality traits by association mapping of a diverse panel of linseed accessions establishes the foundation for assisted breeding and future fine mapping in linseed. Linseed oil is valued for its food and non-food applications. Modifying its oil content and fatty acid (FA) profiles ...
Kalina Warren Vincent WV Diagnostic Systems Division, United States Army Medical Research Institute of Infectious Disease, Fort Detrick, MD - - 2014
Magnetic beads offer superior impurity removal and nucleic acid selection over older extraction methods. The easyMAG®, MagNA Pure, EZ1 Advanced-XL, and Arrows' nucleic acid extraction performance of biothreat agents in blood or buffer was evaluated. All instruments showed excellent performance in blood; however, the easyMAG® had best precision and versatility.
Wu Hao H Key Laboratory of Pesticide & Chemical Biology of Ministry of Education, Institute of Environmental Chemistry, College of Chemistry, Central China Normal University, Wuhan 430079, People's Republic of - - 2014
In this study we comparatively investigate the removal of humic acids with Fe@Fe2O3 core-shell nanowires under anoxic and oxic conditions. The products of humic acids after reacting with Fe@Fe2O3 core-shell nanowires under anoxic and oxic conditions were carefully examined with three-dimensional excitation emission matrix fluorescence spectroscopy and gas chromatography mass ...
Coogan Michael P MP School of Chemistry and Chemical Biology, University of Lancaster, Lancaster, LA1 4YB, - - 2014
Single amino acid chelates (SAACs) and SAAC-like bifunctional ligands can be exploited in the design of a variety of bioconjugates for facile metallation with the M(CO)3 (+) unit with M = (99m) Tc or Re. When the donor groups of the ligand are quinolone, thiazole or other similarly conjugated heterocycles, the rhenium ...
Keith John M JM Janssen Research and Development, L.L.C., 3210 Merryfield Row, San Diego, CA 92121, USA. Electronic address: - - 2014
A series of mechanism based heteroaryl urea fatty acid amide hydrolase (FAAH) inhibitors with spirocyclic diamine cores is described. A potent member of this class, (37), was found to inhibit FAAH centrally, elevate the brain levels of three fatty acid ethanolamides [FAAs: anandamide (AEA), oleoyl ethanolamide (OEA) and palmitoyl ethanolamide ...
Fang Jidun J State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing 100012, China; Shandong Key Laboratory of Eco-Environmental Science for Yellow River Delta, Binzhou University, Binzhou, Shandong Province 256600, - - 2013
The distribution and compound-specific carbon isotope ratios of n-alkanes and fatty acids in a sediment core (63cm) collected from Lake Dianchi were examined to investigate organic matter sources in the eutrophic lake. Fatty acids included free and bound fatty acids. The carbon isotope compositions of individual n-alkanes and fatty acids ...
Wang Xiao-Ping - - 2013
The use of snow and ice cores as recorders of environmental contamination is particularly relevant for per- and polyfluoroalky substances (PFASs) given their production history, differing source regions and varied mechanisms driving their global distribution. In a unique study perfluoroalkyl acids (PFAAs) were analysed in dated snow-cores obtained from high ...
Parmar Dixit D Institut für Organische Chemie, RWTH Aachen University, Landoltweg 1, 52074 Aachen (Germany), Fax: - - 2013
Catalytic fluorolactonisations of aromatic carboxylic acids have been developed. The reactions proceed under mild conditions using the commercially available reagent Selectfluor. A weak phase transfer of the reagent mediated by Na2 CO3 allows the reaction to be conducted in non-polar solvents. Furthermore, by the use of a catalytic amount of ...
Andrés Miriam - - 2013
In this manuscript, the synthesis and biological activity of a series of pyrazole acetic acid derivatives as CRTh2 antagonists is presented. Biological evaluation in vitro revealed that the pyrazole core showed in several cases a different structure-activity relationship (SAR) to that of related indole acetic acid. A potent series of ortho-sulfonyl ...
Pett Christian - - 2013
By displaying different O-glycans in a multivalent mode, mucin and mucin-like glycoproteins are involved in a plethora of protein binding events. The understanding of the roles of the glycans and the identification of potential glycan binding proteins are major challenges. To enable future binding studies of mucin glycan and glycopeptide ...
Zheng Fang-Cai - - 2013
The Fe3O4@C core-shell magnetic nanoparticles with an average size of about 190 nm were synthesized via a one-pot solvothermal process using ferrocene as a single reactant. The sulfonic acid-functionalized Fe3O4@C magnetic nanoparticles were obtained by grafting the sulfonic groups on the surface of Fe3O4@C nanoparticles to produce magnetically recyclable solid ...
Hisamatsu Yosuke - - 2013
Four arms: A quadruple zwitterion based on a pentaerythritol core forms thermoreversible gels in DMSO driven by the formation of ion-paired dimers between the zwitterionic units. Furthermore, it exhibits reversible gel-sol transitions in response to both acid and base.
Huang Huachao H State Key Laboratory of Virology and Joint Laboratory of Invertebrate Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, People's Republic of - - 2014
ha72 of Helicoverpa armigera nucleopolyhedrovirus (a homologue of ac78) was identified as a conserved late baculovirus gene and characterized. HA72 localizes in the intranuclear ring zone. By generating mutants, we showed that HA72 is essential for budded virus (BD) production and occlusion-derived virus (ODV) embedding. HA72 also interacted with P33, ...
Lodowska Jolanta - - 2013
The sugar 3-deoxy-d-manno-oct-2-ulosonic acid (Kdo) is a characteristic component of bacterial lipopolysaccharide (LPS, endotoxin). It connects the carbohydrate part of LPS with C6 of glucosamine or 2,3-diaminoglucose of lipid A by acid-labile α-ketosidic linkage. The number of Kdo units present in LPS, the way they are connected, and the occurrence ...
Padala Kishor - - 2013
Substituted acetanilides reacted with aromatic acids in the presence of [{RuCl2(p-cymene)}2], AgSbF6 and (NH4)2S2O8 in ClCH2CH2Cl at 100 °C for 24 h yielding ortho-benzoxylated acetanilides in good to excellent yields in a highly regioselective manner via C-H bond activation.
Crosa María José - - 2014
In this study the effect of vacuum frying (VF) and traditional frying (TF) on oil degradation, fatty acid composition and alpha-tocopherol content was investigated. Two different refined sunflower oils were used: sunflower oil with high oleic acid content (HOSO) and sunflower oil with synthetic antioxidant (tertiary-butylhydroquinone) (TBHQ-SO). Oil degradation was ...
Liu Xiaoxuan - - 2013
RNAi-based nucleic acid molecules have attracted considerable attention as compelling therapeutics providing safe and competent delivery systems are available. Dendrimers are emerging as appealing nanocarriers for nucleic acid delivery thanks to their unique well-defined architecture and the resulting cooperativity and multivalency confined within a nanostructure. The present review offers a ...
Pan Miaorong - - 2013
In this work, a core-shell-shell structured boronic acid-functionalized magnetic composite microspheres Fe3O4@SiO2@poly (methyl methacrylate-co-4-vinylphenylbornoic acid) (Fe3O4@SiO2@P(MMA-co-VPBA)) with uniform size and fine morphology were synthesized. Here, Fe3O4 magnetic particles were prepared by a solvothermal reaction while the Fe3O4@SiO2 microspheres with a core-shell structure were obtained by a sol-gel process. And then, ...
Liu Yingle - - 2013
A tunable and highly regio- and diastereoselective addition of acyclic silyl dienolates to several α-fluoroalkyl sulfinylimines was developed. By appropriate choice of the Lewis acid catalyst, two new chiral α-fluoroalkyl amines and were obtained in good yields and excellent diastereoselectivities (up to >99 : 1 dr), respectively.
Lemétais Aurélie - - 2013
Tetra-O-acylated sulfolipids are metabolites found in the cell wall of Mycobacterium tuberculosis, the causative agent of tuberculosis. Their role in pathogenesis remains, however, undefined. Here we describe a novel access to model tetra-O-acylated trehalose sulfate derivatives having simple acyl chains. The trehalose core was regioselectively protected using a tandem procedure ...
Zhu Lizhi - - 2013
A mild and efficient dual-mode Lewis acid induced Diels Alder (DA)/carbocyclization cascade cyclization reaction has been developed for construction of the tricyclic core of ent-kaurenoids in one pot with the aid of a theoretical study on the π,σ-Lewis acidities of a variety of Lewis acids. With ZnBr2 as the dual-mode ...
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