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Hamada Shinsuke S 1Department of Urology, National Defense Medical College, Tokorozawa, - - 2014
Fatty acid synthase has been shown to be highly expressed in various types of cancers with increased tumour aggressiveness. In this study we examined the level of fatty acid synthase expression in surgically resected upper urinary tract urothelial carcinoma specimens and evaluated the relations between fatty acid synthase expression and ...
Regueiro Jorge J Nutrition and Bromatology Group, Analytical and Food Chemistry Department, Faculty of Food Science and Technology, Ourense Campus, University of Vigo, Ourense 32004, - - 2014
The availability of biomarkers that allow the estimation of the intake of specific foods and dietary components, as an alternative or addition to self-reported dietary questionnaires, could greatly enhance the effectiveness of nutritional research. The aim of the present study was to assess tartaric acid, one of the major components ...
Tracy Chad R CR Department of Urology, University of - - 2014
We compared 3 animal protein sources for their effect on urinary stone risk. 15 healthy subjects completed a 3 phase, randomized crossover metabolic study. During each 1-week phase, subjects consumed a standard, metabolic diet containing beef, chicken or fish. Serum chemistries and 24-hour urine samples collected at the end of ...
Smith Cynthia R CR National Marine Mammal Foundation, San Diego, California, - - 2014
Nephrolithiasis has been increasingly reported in bottlenose dolphins, with all cases to date being ammonium urate nephrolithiasis. A case-control study was conducted in dolphins with and without evidence of nephrolithiasis, aiming to identify biomarkers and risk factors associated with stone formation in a managed population. Dolphins were sampled in both ...
Sakhaee Khashayar K Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX, 75390-8885, USA, - - 2014
There is global diversity in the prevalence of uric acid (UA) nephrolithiasis. UA nephrolithiasis comprises 8-10 % of all kidney stones in the United States. However, its prevalence is higher in patients with type 2 diabetes mellitus and those with obesity. Three significant urinary abnormalities have been described as the main ...
Kaewdang Onouma O Department of Food Technology, Faculty of Agro-Industry, Prince of Songkla University, Hat Yai, Songkhla 90112, - - 2014
Acid soluble collagen (ASC) and pepsin soluble collagen (PSC) were extracted from the swim bladders of yellowfin tuna (Thunnus albacares) with yields of 1.07% and 12.10%, respectively. Based on electrophoretic patterns, both ASC and PSC consisted of two α-chains (α1 and α2) and were characterised to be type I collagen. ...
Torricelli Fabio Cesar Miranda FC Cleveland Clinic, Urology, 9500 Euclid Avenue / Q10, Cleveland, Ohio, United States, 44195 ; - - 2014
Introduction: Distinguishing calcium oxalate from uric acid stones is critical to identify those patients who may benefit from dissolution therapy, and can also help direct preventive measures for stone growth. Herein, we aim to study whether 24-hour urine analysis may predict the urinary stone composition. Patients and methods: We retrospectively ...
Klinkenberg Joern J 1 IPB, - - 2013
Agrobacterium tumefaciens-derived crown galls of Arabidopsis thaliana contain elevated levels of unsaturated fatty acids and strongly express two fatty acid desaturase genes, FAD3 and SAD6. The fad3-2 mutant with impaired ∝-linolenic acid synthesis developed significantly smaller crown galls under normal, but not under high, relative humidity. This strongly suggests that ...
Khanal Ramesh - - 2013
Dietary polyphenolics can be converted into smaller phenolic acids (PA) by microorganisms in the colon and may contribute to health benefits associated with the parent polyphenolics Urinary excretion of 18 PA and their conjugates were studied, using HPLC/MS/MS, in rats fed AIN93G based diets containing 5% (dry weight basis) of ...
McKelvey Wendy - - 2013
Organophosphates and pyrethroids are the most common classes of insecticides used in the United States. Widespread use of these compounds to control building infestations in New York City (NYC) may have caused higher exposure than in less urban settings. Study objectives were to estimate pesticide exposure reference values for NYC ...
Torricelli Fabio Cesar Miranda - - 2013
To study the impact of dyslipidemia on 24-hour urine analysis and stone composition. We retrospectively identified patients with nephrolithiasis who had a 24-hour urine analysis and lipid profile evaluation within 3 months of each other. Patients were divided in groups based on their total cholesterol (TC), HDL, non-HDL, and triglycerides ...
Bobulescu I Alexandru IA Univ. of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-8885. - - 2013
Idiopathic uric acid nephrolithiasis is characterized by elevated urinary net acid excretion and insufficient buffering by ammonium, resulting in excessively acidic urine and titration of the relatively soluble urate anion to insoluble uric acid. Patients with type 2 diabetes have similar changes in urinary pH, net acid excretion, and ammonium ...
Loes A N - - 2013
Urease is a virulence factor for the Gram-positive urinary tract pathogen Staphylococcus saprophyticus. The susceptibility of this enzyme to chemical inhibition was determined using soluble extracts of S. saprophyticus strain ATCC 15305. Acetohydroxamic acid (Ki = 8.2 μg ml(-1) = 0.106 mmol l(-1) ) and DL-phenylalanine hydroxamic acid (Ki = ...
Goldfarb David S - - 2013
Higher urinary uric acid excretion is a suspected risk factor for calcium oxalate stone formation. Febuxostat, a xanthine oxidoreductase inhibitor, is effective in lowering serum urate concentration and urinary uric acid excretion in healthy volunteers and people with gout. This work studied whether febuxostat, compared with allopurinol and placebo, would ...
Al Shibli Amar - - 2013
Urate urolithiasis in children has been reported in Japan in association with rotavirus (RV) gastro-enteritis (GE). To test the hypothesis that children with RV GE have an increased risk of hyperuricosuria compared with GE presumably caused by other viruses. Prospective analytic cohort study of urinary uric acid excretion in children ...
Moreira Daniel M - - 2013
To determine the differences in 24-hour urine composition between apatite and brushite stone formers. We conducted a retrospective review of 110 calcium phosphate (CaP) stone formers with both stone composition analysis and 24-hour urinalysis available. Analysis of 24-hour urine constituents between apatite and brushite stone formers was performed using univariable ...
Wang Lei - - 2013
Human exposure to p-hydroxybenzoic acid esters (parabens) is a concern, owing to adverse health effects of these compounds. Parabens are metabolized and eliminated from the human bodies within a few hours of exposure. In this study, for the first time, methyl- and ethyl-protocatechuates (OH-MeP and OH-EtP) and their parent compounds, ...
Zhang Guang-Na - - 2013
The property changes of urinary nanocrystallites in 20 cases of uric acid (UA) stone formers after 1week of potassium citrate (K3cit) intake were comparatively studied by X-ray diffraction analysis, Fourier transform infrared spectroscopy, nanoparticle size analysis, and transmission electron microscopy. Before K3cit intake, the urinary crystallites mainly contained UA and ...
Selvaraju R - - 2013
In the present study the human urinary stones were observed in their different chemical compositions of calcium oxalate monohydrate, calcium oxalate dihydrate, calcium phosphate, struvite (magnesium ammonium phosphate), uric acid, cystine, oxammite (ammonium oxalate monohydrate), natroxalate (sodium oxalate), glushinkite (magnesium oxalate dihydrate) and moolooite (copper oxalate) were analyzed using Fourier ...
Kuklev Dmitry V - - 2013
Western diets are enriched in omega-6 vs. omega-3 fatty acids, and a shift in this balance toward omega-3 fatty acids may have health benefits. There is limited information about the catabolism of 3-series prostaglandins (PGs) formed from eicosapentaenoic acid, a fish oil omega-3 fatty acid that becomes elevated in tissues ...
Eynard Aldo R - - 2013
Based on a consistent bulk of experimental and epidemiologic works, we proposed that abnormal metabolism and/or dietary deprivation of essential polyunsaturated fatty acids by inducing a chronic and subclinical essential fatty acid deficiency (EFAD) in urothelial cell membranes may enhance the risk for urinary tract tumor (UTT) development. This threat ...
Asam Stefan - - 2013
The content of tenuazonic acid in human urine was determined by a stable isotope dilution assay (SIDA) that was recently developed for the analysis of food commodities and extensively re-validated for urine matrix in this study. Linearity of the response curve was proven between molar ratios n(labeled standard)/n(analyte) of 0.02-100. ...
Krupp Danika - - 2013
BACKGROUND: The reduced activity of 11β hydroxysteroid dehydrogenase type 2 (11βHSD2) contributes to elevated blood pressure (BP) in clinical syndromes, but its effect on BP in the physiologic range is unclear. OBJECTIVES: We examined the association of 11βHSD2 activity with BP in healthy children independent of known BP-related dietary and ...
Eng Wei Kay - - 2013
Human biotin requirements are unknown and the identification of reliable markers of biotin status is necessary to fill this knowledge gap. Here, we used an outpatient feeding protocol to create states of biotin deficiency, sufficiency and supplementation in sixteen healthy men and women. A total of twenty possible markers of ...
Cosnier Frédéric - - 2013
Abstract 1. Toluene (TOL) is a neurotoxic, ototoxic and reprotoxic solvent which is metabolized via the glutathione pathway, producing benzylmercapturic, o-, m- and p-toluylmercapturic acids (MAs). These metabolites could be useful as biomarkers of TOL exposure. 2. The aims of this study were (1) to provide data on MAs excretion ...
Payne Richard G - - 2013
This chapter describes the fabrication of a polyglycolic acid (PGA)-based scaffold used to tissue engineer a Neo-Urinary Conduit™.
Miryaghoubzadeh J - - 2013
Bladder cancer cells appear to have an altered lipid metabolism as evidenced by modulated lipogenic enzymes. The aim of this study is to investigate differences in tissue fat composition between malignant and adjacent normal urinary bladder tissue. Normal-appearing and malignant bladder tissues were collected from 31 patients with high-grade (Ta) ...
Raterman Erica L - - 2013
Community-acquired urinary tract infections (UTIs) are commonly caused by uropathogenic Escherichia coli (UPEC). We hypothesize that chemotaxis toward ligands present in urine could direct UPEC into and up the urinary tract. Wild-type E. coli CFT073 and chemoreceptor mutants with tsr, tar, or aer deletions were tested for chemotaxis toward human ...
Niesser Mareile - - 2013
Folate status, as reflected by red blood cell (RCF) and plasma folates (PF), is related to health and disease risk. Folate degradation products para-aminobenzoylglutamate (pABG) and para-acetamidobenzoylglutamate (apABG) in 24 hour urine have recently been shown to correlate with blood folate. Since blood sampling and collection of 24 hour urine ...
Knight Toyin A - - 2013
A tissue-engineered product needs to be properly characterized in order to be used in vivo. Many methods can be used to characterize a scaffold during creation of a tissue-engineered product. This chapter looks at the mechanical (tensile testing) and biological characterization (cell viability and proliferation) of a polyglycolic acid-based scaffold ...
Hong Seul Hee - - 2013
To investigate the association of FADS gene polymorphisms with age-related changes in polyunsaturated fatty acids (PUFAs) in serum phospholipids and oxidative stress markers. We genotyped 122 nonobese men aged 35-59 years without any known diseases at baseline for rs174537 near FADS1 (FEN1 rs174537G > T), FADS2 (rs174575, rs2727270), and FADS3 ...
Tielen Petra - - 2013
Biofilms of the Gram-negative bacterium Pseudomonas aeruginosa are one of the major causes of complicated urinary tract infections with detrimental outcome. To develop novel therapeutic strategies the molecular adaption strategies of P. aeruginosa biofilms to the conditions of the urinary tract were investigated thoroughly at the systems level using transcriptome, ...
Kullmann F Aura - - 2013
Time- and vehicle-related variability of bladder and urethral rhabdosphincter (URS) activity as well as cardiorespiratory and blood chemistry values were examined in the acetic acid-induced bladder irritation model in α-chloralose-anesthetized female cats. Additionally, bladder and urethra were evaluated histologically using Mason trichrome and toluidine blue staining. Urodynamic, cardiovascular and respiratory ...
Sinthusamran Sittichoke - - 2013
Acid soluble collagens (ASCs) from skin and swim bladder of seabass (Lates calcarifer) were isolated and comparatively characterised. Higher yield (28.5%) was obtained for ASC from swim bladder, compared with that from skin (15.8%). ASCs from both skin and swim bladder had the similar protein patterns and were identified to ...
Chae Ji Yun - - 2013
Uric acid stones are the most readily dissolvable of all types of urinary stones. The present paper describes two patients with uric acid stones in kidney and ureter, whom we have treated successfully only by a combination of increased fluid intake and adequate dietary modification.
Grollman Arthur P - - 2012
This review constitutes an overview of our investigations of aristolochic acid nephropathy, a chronic kidney disease associated with carcinomas of the upper urinary tract. Our studies began by confirming the hypothesis that chronic dietary poisoning by aristolochic acid was responsible for endemic (Balkan) nephropathy. A unique TP53 mutational signature in ...
Ishizuka Osamu - - 2012
Historically, α(1) -adrenoceptors have been classified into three subtypes (α(1) (A) , α(1) (B) and α(1) (D) ) that are widely distributed in various organs. Research on the α(1) (D) -adrenoceptors in the bladder, urethra and prostate has focused on the relationship between expression levels and symptoms of bladder outlet ...
Mehta Tapan H - - 2012
Recent work has highlighted the strong relationships among obesity, diabetes, and the metabolic syndrome as causes of low urinary pH. Low urinary pH in turn is the major urinary risk factor for uric acid stones. Unlike calcium stones, uric acid stones can be dissolved and easily prevented with adequate urinary ...
Selvaraju R - - 2012
FT-Raman spectroscopy is the most useful tool for the purpose of bio-medical diagnostics. In the present study, FT-Raman spectral method is used to investigate the chemical composition of urinary calculi. Urinary calculi multi-components such as calcium oxalate, hydroxyl apatite, struvite and uric acid are studied. FT-Raman spectrum has been recorded ...
Zhang Jun - - 2012
To compare the effect of zoledronic acid in treatment and prevention of osteoporosis with placebo. Random control trials regarding zoledronic acid in treatment of osteoporosis were retrieved by selecting Medline, EMbase and Pubmed databases till April 2012. The RevMan software was used for all of the statistical analysis. A total ...
Maciel Alexandre Toledo - - 2012
Intensive care unit survivors and non-survivors have distinct acid-base profiles. The kidney's regulation of urinary electrolytes and the urinary strong ion difference plays a major role in acid-base homeostasis. The aim of this study was to evaluate the potential utility of daily spot urinary electrolyte measurement in acid-base and renal ...
Halim Sharif A - - 2012
QUESTION In patients with cardiovascular (CV) disease, are omega-3 fatty acid supplements (eicosapentaenoic acid [EPA] and docosahexaenoic acids [DHA]) effective for secondary prevention? REVIEW SCOPE Included studies compared omega-3 fatty acid supplements used for ≥ 1 year with placebo in adults ≥ 18 years of age who had a history of CV ...
Morimoto Yukiko - - 2012
Composition of dietary fatty acid intake, which influences cytokine production, may contribute to the development of non-Hodgkin's lymphoma (NHL). Serum lipid levels may serve as biomarkers of inflammation associated with NHL risk. We conducted a case-control analysis (275 cases and 549 controls) nested within the Multiethnic Cohort Study (whites, Japanese ...
Mokhtarani M - - 2012
We have analyzed pharmacokinetic data for glycerol phenylbutyrate (also GT4P or HPN-100) and sodium phenylbutyrate with respect to possible dosing biomarkers in patients with urea cycle disorders (UCD). These analyses are based on over 3000 urine and plasma data points from 54 adult and 11 pediatric UCD patients (ages 6-17) ...
van Veggel M - - 2012
van Veggel M, Olofinjana O, Davies G, Taylor D. Clozapine and gastro-oesophageal reflux disease (GORD) - an investigation of temporal association. Objective:  To establish the temporal relationship between prescription of acid-suppressant therapy, GORD and clozapine prescribing. Method:  In this retrospective cohort study, we identified out-patients prescribed clozapine and other atypical ...
Lee Lai Kuan - - 2012
The present work explores the effect of dietary omega-3 polyunsaturated fatty acids (PUFAs) intake on lipid peroxidation among mild cognitive impairment (MCI) patients. The plasma lipid hydroperoxide (LPO) levels in 67 MCI patients were compared to those of 134 healthy elderly controls. Omega-3 PUFA intake was assessed using an interviewer-administered ...
Kadlec Adam O - - 2012
To determine which metabolic syndrome (MetS) factors lead to differences in stone composition in a multivariate analysis. We retrospectively reviewed medical charts of patients who had a kidney stone removed over a 5-year period (2006-2011). MetS factors (obesity [body mass index {BMI} >30], diabetes mellitus [DM], hypertension [HTN], and dyslipidemia ...
Osuka Akinori - - 2012
ABSTRACT: INTRODUCTION: We have reported that altered gut flora is associated with septic complications and eventual death in critically ill patients with systemic inflammatory response syndrome. It is unclear how fecal pH affects these patients. To determine whether fecal pH can be used as an assessment tool for the clinical ...
Figueredo Carlos Marcelo - - 2012
Background: Long chain polyunsaturated fatty acids Omega-3 and -6 (LC-PUFA n-3 n-6) can function as important inflammatory modulators and also have a strong effect in the proresolving inflammatory processes. Aim: Our aim was to analyze the serum levels of docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA) and arachidonic ...
Gracie D J - - 2012
Background  Many physicians do not consider the diagnosis of bile acid malabsorption in patients with chronic diarrhea, or do not have access to testing. We examined yield of 23-seleno-25-homo-tauro-cholic acid (SeHCAT) scanning in chronic diarrhea patients, and attempted to identify predictors of a positive test. Methods  Consecutive patients with chronic ...
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