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Ren Lei - - 2011
A highly enantioselective Friedländer condensation has been established by using chiral Brønsted acids in combination with achiral amines to give quinolines in high yields (up to 99%) and with excellent enantioselectivities (up to 95%).
Xie Cen - - 2011
Ultra performance liquid chromatography coupled with hybrid quadrupole/ion mobility/orthogonal acceleration time-of-flight (<i>oa</i>-TOF) mass spectrometry (UPLC-IM-MS) was used to study the isomeric transformations of <i>trans</i>-5-caffeoylquinic acid, an extremely active compound present in multiple vegetables, fruits, and beverages. The UPLC/<i>oa</i>-TOF MS results proved that in phosphate buffer (pH 7.4), plasma or urine ...
Wang Mingming - - 2011
In the present study, we focus on the interactions between poly(propylene imine) (PPI) dendrimer and eighteen of the twenty common amino acids by several NMR techniques including NMR titrations and NOESY analysis. Surface ionic interactions and interior encapsulations were observed and the binding behavior of amino acids with PPI dendrimer ...
Lumia Mirka - - 2011
To cite this article: Lumia M, Luukkainen P, Kaila M, Tapanainen H, Erkkola M, Uusitalo L, Niinistö S, Kenward MG, Ilonen J, Simell O, Knip M, Veijola R, Virtanen SM. Dietary fatty acid composition during pregnancy and the risk of asthma in the offspring. Pediatr Allergy Immunol 2011; Doi: 10.1111/j.1399-3038.2011.01202.x ...
Müller Werner E G - - 2011
BACKGROUND: The formation of the spicules in siliceous sponges involves the formation of cylinder-like structures in the extraspicular space, composed of the enzyme silicatein and the calcium-dependent lectin. SCOPE OF REVIEW: Molecular cloning of the cDNAs (carotene dioxygenase, retinal dehydrogenase, and BMB-1 [bone morphogenic protein-1]) from the demosponge Suberites domuncula ...
Rajakannu Palanisamy - - 2011
In the title 1/2 adduct, C(10)H(8)N(2)·2C(7)H(6)O(2)S, the dihedral angle between the pyridine rings is 18.41 (11)°. In the thio-phene-acrylic acid mol-ecules, the dihedral angles between the respective thio-phene and acrylic acid units are 5.52 (17)° and 23.92 (9)°. In the crystal, the components are linked via O-H⋯N hydrogen-bonding inter-actions, forming units of two ...
Shen Ruwei - - 2011
A facile, highly stereo- and regioselective hydrometallation of alkynes generating alkenylmetal complex is disclosed for the first time from a reaction of alkyne, carboxylic acid and a zero valent group 10 transition metal complex M(PEt3)4 (M = Ni, Pd, Pt). A mechanistic study showed that the hydrometallation does not proceed ...
Cohen Juliana F W JF Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA. - - 2011
It is unclear from previous studies whether total or common subtypes of trans fatty acids are associated with fetal growth. We examined associations of maternal trans fatty acid intake during pregnancy with fetal growth. We studied 1369 mother-child pairs participating in Project Viva-a prospective cohort study of pregnant women and ...
Ballatore Carlo - - 2011
Cyclopentane-1,3-diones are known to exhibit pK(a) values typically in the range of carboxylic acids. To explore the potential of the cyclopentane-1,3-dione unit as a carboxylic acid isostere, the physical-chemical properties of representative congeners were examined and compared with similar derivatives bearing carboxylic acid or tetrazole residues. These studies suggest that ...
Sanna Daniele - - 2011
The interaction of VO(2+) ion with ligands of biological interest that are present in important metabolic pathways-2-oxopropanoic acid (pyruvic acid, pyrH), 3-hydroxy-2-oxopropanoic acid (3-hydroxypyruvic acid, hydpyrH), oxobutanedioic acid (oxalacetic acid, oxalH(2)), (S)-hydroxybutanedioic acid (l-malic acid, malH(2)), and 2,3-dihydroxy-(E)-butanedioic acid (dihydroxyfumaric acid, dhfH(2))-was described. Their complexing capability was compared with that ...
Pejin B - - 2011
The chemical composition of Rhodobryum ontariense (Kindb.) Kindb. has not been previously investigated. Fatty acids of this moss were analysed qualitatively and quantitatively with an aim to identify its corresponding pattern. A total of eight fatty acids were identified including two acetylenic ones: 9,12,15-octadecatrien-6-ynoic acid (42.26%), α-linolenic acid (20.32%), palmitic ...
Barbana Chockry - - 2011
α-Lactalbumin (α-LA) is a whey protein that has been extensively studied for its folding properties and its ability to bind several cations. An interesting property of α-LA is its ability to interact with fatty acids, although this interaction requires the previous unfolding of the protein by removing the Ca(2+) bound. ...
Järvinen Riikka L - - 2011
: Evaporative dry eye is associated with meibomian gland dysfunction and abnormalities of the tear film lipids. Dry eye is known to be affected positively by intake of linoleic and γ-linolenic acids and n-3 fatty acids. Oral sea buckthorn (Hippophaë rhamnoides) (SB) oil, which contains linoleic and α-linolenic acids and ...
Cho Jui-Ying - - 2011
A new ferulic acid ester derivative, tetracosane-1,24-diyl di[(Z)-ferulate] (1), and a new ellagic acid derivative, 3,4 : 3',4'-bis(O,O-methylene)ellagic acid (2), have been isolated from leaves and twigs of Pachycentria formosana, together with eight known compounds. Their structures were determined by in-depth spectroscopic and mass-spectrometric analyses. Among the isolated compounds, oleanolic acid (6), ...
Szajwaj Barbara - - 2011
Two new derivatives of phenylpropenoic acids, N-trans-feruloyl-L-DOPA and O-trans-caffeoyl-malic acid dimethyl ester, along with four known N-trans-caffeoyl-L-DOPA (clovamide), N-trans-caffeoyl-L-DOPA-methyl ester, O-trans-caffeoyl-malic acid, O-trans-feruloyl-malic acid and quercetin 3-O-beta-D-glucopyranoside were isolated from the aerial parts of Trifolium pallidum. Their structures were elucidated by extensive spectroscopic methods including 1D- (1H, 13C) and 2D-NMR ...
Corma Avelino - - 2011
A series of bifunctional organic catalysts containing acid and basic sites with ionic liquid characteristics have been prepared and their catalytic activity and reaction coordinate for aldol and Knoevenagel condensations have been compared. While the only factor controlling catalyst activity for the Knoevenagel condensation was the distance between the acid ...
Degen Christian - - 2011
Conjugated fatty acids (CFAs) exhibit growth inhibitory effects on colon cancer in vitro and in vivo. To investigate whether the anticancerogenic potency depends on number or configuration of the conjugated double bonds, the effect of conjugated linoleic acid; (CLA; C18:2) isomers and conjugated linolenic acid (CLnA; C18:3) isomers on viability ...
Saracoglu Hatice Taner - - 2011
The fatty acid composition of five endemic Bupleurum (Apiaceae) species was analysed by GC technique for their nutritional value. The amount of oil content of the species varied from 3.77% to 7.03%. Twenty-one fatty acids were identified in the oils. The fatty acid composition of the studied species contained oleic, ...
Lee Ki Hoon - - 2011
Two novel caffeoylmalic acid methyl esters, 2-<i>O</i>-(<i>trans</i>-caffeoyl)-malic acid 1-methyl ester (<b>6</b>) and 2-<i>O</i>-(<i>trans</i>-caffeoyl)-malic acid 4-methyl ester (<b>7</b>), were isolated from pear (<i>Pyrus pyrifolia</i> Nakai cv. Chuhwangbae) fruit peels. In addition, 5 known hydroxycinnamoylmalic acids and their methyl esters were identified: 2-<i>O</i>-(<i>trans</i>-coumaroyl)-malic acid (<b>1</b>), 2-<i>O</i>-(<i>cis</i>-coumaroyl)-malic acid (<b>2</b>), 2-<i>O</i>-(<i>cis</i>-coumaroyl)-malic acid 1-methyl ester ...
Smith Donna L - - 2011
In the presence of substoichiometric Pd(OAc)(2), carboxylic acids undergo highly regio- and stereoselective additions to ynamides to provide α-acyloxyenamides.
Osaki Tomoe - - 2011
The hydrogen bond formations between pyrazine and formic acids and between pyrazine and trichloroacetic acids were studied through observation of the Raman and infrared spectra for mixture of pyrazine and formic acid and also mixture of pyrazine and trichloroacetic acid at 77K. It was observed that the mutual exclusion principle ...
Wang Ming Li - - 2011
Castor has tremendous potential as a feedstock for biodiesel production. The oil content and fatty acid composition in castor seed are important factors to determine the price for production and affect the key fuel properties of biodiesel. There were 1033 available castor accessions collected or donated from 48 countries worldwide ...
Wagner Karen K Department of Entomology and UC Davis Cancer Center, University of California Davis, Davis, CA 95616, - - 2011
The soluble epoxide hydrolase (sEH) enzyme regulates the levels of endogenous epoxygenated fatty acid (EFA) lipid metabolites by rapidly degrading these molecules. The EFAs have pleiotropic biological activities including the modulation of nociceptive signaling. Recent findings indicate that the EFAs, in particular the arachidonic acid (AA) derived epoxyeicosatrienoic acids (EETs), ...
Oh Kwang-Seok - - 2011
Salvianolic acid A, an active compound present in Salvia miltiorrhiza, is a phenolic carboxylic acid derivative, ((2R)-3-(3,4-Dihydroxyphenyl)-2-[(E)-3-[2-[(E)-2-(3,4-dihydroxyphenyl) ethenyl]-3,4-dihydroxyphenyl] prop-2-enoyl]oxypropanoic acid). The present study was performed to investigate the underlying mechanisms of anti-inflammatory effects with salvianolic acid A, specially focused on nuclear factor κB (NF-κB) signaling pathway by targeting the IκB ...
Böhle Tony - - 2011
The title terephthalic acid derivatives, namely 2,5-dimethoxyterephthalic acid, C(10)H(10)O(6), (I), and 2,5-diethoxyterephthalic acid, C(12)H(14)O(6), (II), exhibit nearly planar molecular structures, with maximum deviations from the least-squares planes calculated for all non-H atoms of 0.0418 (6) and 0.0902 (10) Å for (I) and (II), respectively. The molecules of both title compounds contain an inversion ...
Karaköse Hande - - 2011
Stevia Rebaudiana leaves are used as a zero-calorie natural sweetener in a variety of food products in Asian countries especially in Japan. In this study, the chlorogenic acids of stevia rebaudina have been investigated qualitatively and quantitatively by LC-MSn. Twenty four chlorogenic acids were detected and nineteen of them were ...
Beyer Markus - - 2011
OBJECTIVES: The consumption of acidic soft drinks may lead to demineralization and softening of human dental enamel, known as dental erosion. The aims of this in vitro study were to determine: (i) if different acids with a similar sensorial acidic taste lead to different hardness loss of enamel and (ii) ...
Takasaki Junichi - - 2011
Inhibition of amyloid-β (Aβ) aggregation is an attractive therapeutic strategy for treatment of Alzheimer's disease (AD). We previously reported that vitamin A and β-carotene inhibit fibrillation of Aβ40 and Aβ42 (Ono et al, 2004, Exp Neurol). In this study, we firstly examined the effects of vitamin A (retinoic acid, retinol, ...
Kim Kyung Hun - - 2011
Ursolic acid (3-hydroxy-urs-12-en-28-oic acid) is a pentacyclic triterpenoid derived from leaves, berries, fruits, and flowers of medicinal plants, such as Rosemarinus officinalis. Ursolic acid has been shown to inhibit tumorigenesis, tumor promotion, and suppress angiogenesis. In our present study, we found that ursolic acid decreased cell proliferation rate and induce ...
Saeed Sumayya - - 2011
Paniculacin (1), a new coumarin derivative, has been isolated from the ethyl acetate soluble fraction of the ethanolic extract of Murraya paniculata along with umbelliferone, scopoletin, 4-hydroxybenzoic acid, trans-cinnamic acid, and β-sitosterol. Their structures were elucidated on the basis of spectral data.
Johnston Ian - - 2011
Bile acid malabsorption occurs when there is impaired absorption of bile acids in the terminal ileum, so interrupting the normal enterohepatic circulation. The excess bile acids in the colon cause diarrhea, and treatment with bile acid sequestrants is beneficial. The condition can be diagnosed with difficulty by measuring fecal bile ...
Calder Philip C - - 2011
Inflammation underlies many common conditions and diseases. Fatty acids can influence inflammation through a variety of mechanisms, including acting via cell surface and intracellular receptors/sensors that control inflammatory cell signalling and gene expression patterns. Some effects of fatty acids on inflammatory cells appear to be mediated by, or at least ...
Najbjerg Heidi - - 2011
In the present study the metabolic response to various fatty acids was investigated in HepG2 cells by using a 1H NMR-based approach. In order to elucidate the effect of cis-/trans- configuration, the cells were exposed to either oleic acid (C18:1 cis-9), elaidic acid (C18:1 trans-9), vaccenic acid (C18:1 trans-11), linoleic ...
Raghuraman Arjun - - 2011
Peptidomimetics 1-3 were prepared from amino acid-derived tetramic acids 7 as the key starting materials. Calculations show that preferred conformations of 1 can align their side-chain vectors with amino acids in common secondary structures more effectively than conformations of 3. A good fit was found for a preferred conformation of ...
Oh Dongyep - - 2011
Genetic associations of fatty acid composition with exonic single nucleotide polymorphisms (SNPs) in the gene encoding fatty acid synthase (FASN) were examined using 513 Korean cattle. All five individual SNPs of g.12870 T>C, g.13126 T>C, g.15532 C>A, g.16907 T>C and g.17924 G>A were associated with a variety of fatty acid ...
Qiang Zhiyi Z Department of Food Science and Human Nutrition, Iowa State University, Ames, IA, USA. - - 2011
Rosmarinic acid (RA), a caffeic acid-related compound found in high concentrations in Prunella vulgaris (self-heal), and ursolic acid (UA), a pentacyclic triterpene acid concentrated in Salvia officinalis (sage), have been traditionally used to treat inflammation in the mouth, and may also be beneficial for gastrointestinal health in general. To investigate ...
Shukla Ekta - - 2011
The fatty acid methyl ester (FAME) analysis of the 12 heterocystous cyanobacterial strains showed different fatty acid profiling based on the presence/absence and the percentage of 13 different types of fatty acids. The major fatty acids viz. palmitic acid (16:0), hexadecadienoic acid (16:2), stearic acid (18:0), oleic acid (18:1), linoleic ...
Bolchi Cristiano - - 2011
Mimetics of the C-terminal CAAX tetrapeptide of Ras protein were designed replacing internal dipeptide AA with 4-amino-2-phenylbenzoic acid and cysteine (C) with 2-amino-4-thiazolyl-, 2-mercapto-4-thiazolyl-, 2-mercapto-4-imidazolyl- and 2-methylmercapto-4-thiazolyl-acetic or propionic acid. The compound in which C is replaced by 2-amino-4-thiazolylacetic acid inhibited FTase activity in the low nanomolar range and showed ...
Hamberg Mats - - 2011
The linoleate 9-lipoxygenase product 9(S)-hydroperoxy-10(E),12(Z)-octadecadienoic acid was stirred with a crude enzyme preparation from the beetroot (Beta vulgaris ssp. vulgaris var. vulgaris) to afford a product consisting of 95% of 9(S),12(S),13(S)-trihydroxy-10(E)-octadecenoic acid (pinellic acid). The linolenic acid-derived hydroperoxide 9(S)-hydroperoxy-10(E),12(Z),15(Z)-octadecatrienoic acid was converted in an analogous way into 9(S),12(S),13(S)-trihydroxy-10(E),15(Z)-octadecadienoic acid (fulgidic ...
O Proinsias Keith - - 2011
The acid-sensitivity of vitamin B12 derived mono- and diamides was studied. It was found that the use of reductive ring-opening of lactone moiety deactivated undesired decomposition of c-mono- and c,d-diamides under acidic conditions. As a result reactions gave respectively c- or d-acids which were further functionalized via coupling with amino ...
Moyano M A - - 2011
Skin becomes thin, dry, pale, and finely wrinkled with age. Retinoids are a large class of compounds that are important in modern therapy for dermatological treatment of wrinkled skin. Of the retinoids, retinol and vitamin A palmitate are thought to induce thickening of the epidermis and to be effective for ...
White H M - - 2011
Pyruvate carboxylase (PC) is a critical enzyme in supplying carbon for gluconeogenesis and oxaloacetate for the tricarboxylic acid cycle. The bovine PC (EC 6.4.1.1) gene contains 3 promoter sequences (P3, P2, and P1 from 5' to 3'). Physiological stressors, including the onset of calving and feed restriction, lead to elevated ...
Sasaki Yasunari - - 2011
Retinoid-mediated signal transduction plays a crucial role in the embryogenesis of various organs. We previously reported the successful induction of anorectal malformations in mice using retinoic acid (RA). Retinoic acid controls the expression of essential target genes for cell differentiation, morphogenesis, and apoptosis through a complicated interaction in which RA ...
Lemaitre Rozenn N - - 2011
Long-chain n-3 polyunsaturated fatty acids (PUFAs) can derive from diet or from α-linolenic acid (ALA) by elongation and desaturation. We investigated the association of common genetic variation with plasma phospholipid levels of the four major n-3 PUFAs by performing genome-wide association studies in five population-based cohorts comprising 8,866 subjects of ...
Mor Adam - - 2011
We hypothesized that Ras proximate 1 (Rap1) functions as an additional target for farnesylthiosalicylic acid (FTS) or its derivatives, and that the inhibition of Rap1 in lymphocytes by these agents may represent a method for treating inflammatory disorders. Indeed, we found that FTS-amide (FTS-A) was able to inhibit the elicitation ...
Rowland Steven J SJ Petroleum and Environmental Geochemistry Group, Biogeochemistry Research Centre, University of Plymouth, Drake Circus, Plymouth PL4 8AA, UK. - - 2011
The identification of most individual members of the complex mixtures of carboxylic acids found in petroleum ('naphthenic acids') has eluded chemists for over a century; they remain unresolved by conventional gas chromatographic methods. Recently, however, we successfully used two-dimensional comprehensive gas chromatography/mass spectrometry to identify numerous individual diamondoid acids in ...
Otrubova Katerina K Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey, Pines Road, La Jolla, CA 92037, - - 2011
A summary of the discovery and advancement of inhibitors of fatty acid amide hydrolase (FAAH) is presented.
Laverroux S - - 2011
In ruminants, cis and trans C18:1 isomers are intermediates of fatty acid transformations in the rumen and their relative amounts shape the nutritional quality of ruminant products. However, their exact synthetic pathways are unclear and their proportions change with the forage:concentrate ratio in ruminant diets. This study traced the metabolism ...
Chavan Machindra J - - 2011
Kaur-16-en-19-oic acid was isolated from the bark of Annona reticulata and studied for its analgesic and antiinflammatory activity. Analgesic activity was assessed using the hot plate test and acetic acid-induced writhing, and the antiinflammatory activity using the carrageenan induced rat paw oedema method. Kaur-16-en-19-oic acid, at doses of 10 and ...
Jose D Amilan - - 2011
The synthesis of new P═O-disubstituted receptors with appended crown ethers and their properties as receptors for dicarboxylic acids have been studied. High affinities have been observed (oxalic and malonic acids with 4-, 5-, 6-, or 8-crown ethers). Binding of a cationic effector within the crown ether unit resulted in a ...
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