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Yamanaka W K - - 1984
The study was conducted to determine the adequacy of fat infusion in preventing essential fatty acid deficiency during parenteral feeding. Eight adult patients receiving marrow transplantation for the treatment of leukemia were studied. Total daily intravenous and oral calorie and fat intakes were monitored. Insignificant amounts of food were consumed ...
Wolff J A - - 1984
Plasma and red cell fatty acids were measured in 44 children with third degree malnutrition: 22 children with marasmus, 11 children with kwashiorkor, and 11 with marasmic kwashiorkor (MK). The presence of edema, dermatosis, hair changes, and hypoalbuminemia were positively correlated with the red cell percentage linoleic acid and negatively ...
O'Neill I E - - 1984
Isolated hepatocytes synthesize fatty acids and cholesterol from lactate and acetate with lactate being the more effective substrate. Biotin deficiency decreased fatty acid synthesis from both substrates but stimulated cholesterogenesis. Exposure of intact hepatocytes to oxalate inhibited fatty acid and cholesterol synthesis from lactate, this effect was enhanced in biotin-deficient ...
Levine S - - 1984
In experiments on essential fatty acid deficiency, various strategems have been used to balance the deficient and control groups for all nutrients except essential fatty acids. We suggest the use of a single fat-free diet for both groups, with essential fatty acids administered parenterally to the control (nondeficient) group once ...
Igisu H - - 1984
The glycolipid composition of the spinal cord, sciatic nerve, kidney, liver and lung of twitcher mice, neurological mutants caused by a genetic deficiency of galactosylceramidase activity, was analyzed during development. No abnormal increase of galactosylceramide or sulfatide was detected in the spinal cord and the sciatic nerve at any age. ...
Baier W - - 1983
In one 21-week-old fetus with prenatally diagnosed metachromatic leukodystrophy, galactolipid contents were determined in the forebrain cortex, cerebellum, brainstem, spinal cord, and kidney and compared to an appropriate control. Spinal cord and kidney showed the highest sulfatide accumulation as a consequence of deficient cerebroside sulfatase activity. No increase, but a ...
Wertz P W - - 1983
The epidermal sphingolipids from rats maintained on either a rat stock diet or a fat-free diet have been analyzed. Thin-layer chromatographic analyses have revealed glucosylceramides, acylglucosylceramides and four fractions of ceramides, one of which proved to be an acylceramide. The relative amounts of the glucosylceramides, acylglucosylceramides and acylceramides were increased ...
Buenrostro J L - - 1983
Oral inoculation with Lactobacillus acidophilus and dietary supplementation with antibiotics were compared in broiler chicks fed various levels of biotin to determine their effect on the biotin status of the chicks. Lactobacillus acidophilus inoculation of broiler chickens fed a diet marginally deficient in biotin (56 micrograms/kg) caused a significant decrease ...
Alam S Q - - 1983
Two nutritional models, an essential fatty acid deficiency model and the feeding of saturated versus unsaturated fats, were used in a feeding study in order to assess the relationship between tissue fatty acid composition and the activities of some membrane-associated enzymes. Purified diets containing 7% hydrogenated coconut oil, 7% corn ...
McCarthy M C - - 1983
Conflicting anecdotal reports about the efficacy of topical linoleate in managing essential fatty acid deficiency prompted this prospective study of 10 critically ill surgical patients receiving continuous total parenteral nutrition (TPN). Ten ml of corn oil (4800 mg of linoleate) were massaged into the skin daily commencing after 7.7 +/- ...
Williams P - - 1983
Erythrocytes of both normal and glucose-6-phosphate dehydrogenase (G-6-PD)-deficient humans responded in a dose-dependent manner to the oxidant stress of methyl oleate hydroperoxide (MOHP) as measured by decreases in G-6-PD activity, increases in methemoglobin (METHB) levels, and decreases in reduced glutathione (GSH). The G-6-PD-deficient erythrocytes displayed a markedly enhanced sensitivity to ...
Jelen S - - 1983
Changes in the fatty acid pattern of plasma lipid in four different groups of polytraumatized patients were investigated. All of the patients received amino acid solutions containing 0.24 gN/day/kg body weight and 30 kal/day/kg body weight (BW). In group 1, all calories were administered as carbohydrates (glucose and fructose). In ...
Niederwieser A - - 1983
A boy, aged 7 months, of consanguineous parents presented with an acute onset of vomiting, fever, nonketotic hypoglycemia and acidosis and died from cardiac arrest after ventricular fibrillation. He had hepatomegaly and echocardiographically a non-obstructive cardiomyopathy. Autopsy was not allowed. After birth the child had suffered from a severe respiratory ...
De Tomas M E - - 1983
The effect of protein deficiency on the activity of delta 6 desaturase in the mother during lactation was determined in the liver microsomal fraction and the fatty acid composition of milk lipids from the analyzed stomach contents. The activity of delta 6 desaturase was profoundly affected by protein deprivation during ...
McComas C F - - 1983
This report outlines the clinical, electrophysiologic, and morphologic findings in seven patients with adult acid maltase deficiency. The diagnosis was confirmed biochemically in four of these individuals. Adult acid maltase deficiency must be considered whenever clinical diagnoses of polymyositis, especially the chronic form, and limb-girdle muscular dystrophy are being entertained.
Stein T P - - 1983
A 39-year-old female with scleroderma was maintained on total parenteral nutrition (TPN) at home for four years. She received 2 units of a 10% fat emulsion per week in which 55% of the fatty acids were from linoleate and 7% from linolenate. She was initially placed on TPN because she ...
Hansen R C - - 1983
A refractory dermatitis resembling acrodermatitis enteropathica was the manifesting sign in a 5-month-old male infant with cystic fibrosis, preceding pulmonary and gastrointestinal tract symptoms by two months. The eruption was clearly nutritionally responsive. Biochemical evidence was shown for deficiencies of zinc, essential fatty acids, and protein. Altered prostaglandin metabolism was ...
Becker W - - 1983
Young rats fed a diet providing 0.3, 3 or 10% of the energy as essential fatty acids (EFA) were given a single intravenous dose of albumin-bound 1-14C-linoleic acid. 1 animal from each group was killed at 1 and 18 h, respectively, after the injection and submitted to whole-body autoradiography. In ...
O'Brien P M - - 1983
Vascular sensitivity to angiotensin II was determined in the mid-trimester of pregnancy in women after taking a diet with supplemented essential fatty acids and vitamins. The essential fatty acids linoleic and dihommogammalinolenic acid were administered as evening primrose oil capsules (Efamol) for one week prior to the study. Vascular sensitivity ...
Huang Y S - - 1983
Methyl linoleate (18:2 omega 6) was administered to rats deficient in essential fatty acids (EFA) and the effects on osmotic fragility and lipid composition of their red blood cells were studied. Even if they remained deficient in omega-3 fatty acids, the fragile red cells of EFA-deficient rats were remarkably strengthened ...
Gourley G R - - 1982
Gas chromatography was used to determine the fatty acid composition of total lipids extracted from plasma and erythrocytes of five patients who had received an hepatic portoenterostomy for treatment of extrahepatic biliary atresia. Three patients, including one with successful surgery, demonstrated evidence of essential fatty acid deficiency, including decreased levels ...
Jain I S - - 1982
Of the 800 presbyopes studied, 286 (35.75%) entered presbyopia at or before the age of 38 years. About 63% of these patients lived in rural areas and 37% in urban areas. Environmental conditions including high average temperature, much ultraviolet radiation, chronic deficiency of essential amino acids, and exposure to toxic ...
Takahashi M - - 1982
Marked changes in the structure and metabolism of lipids were observed at scaly lesions induced in the skin of rats by the feeding for four months of a diet deficient in essential fatty acids. The concentration of neutral lipids increased in the experimental skin specimens with the exception of free ...
Marzouki Z M - - 1982
The effect of essential fatty acid deficiency on lipids of separated rat Sertoli and germinal cells was determined at various time intervals after the animals were placed on a fat-free diet. Alterations in the fatty acid composition typical of essential fatty acid deficiency were noted in the Sertoli cells as ...
Shakespeare P G - - 1982
The relative proportions of the five major fatty acids present in the epidermal polar lipids isolated by swabbing the surface of the skin over hypertrophic scars were compared with the relative proportions observed in normal skin. This comparison necessitates taking the 'normal' sample from unburned skin in an anatomically equivalent ...
Tabrett D G - - 1982
A new intravenous safflower oil emulsion (Liposyn, Abbott) was administered to 23 patients receiving total parenteral nutrition. In a prospective clinical trial, 500 ml of the 10% emulsion was administered each day for a minimum of 10 days. Plasma fatty acid estimations showed a rise in linoleic acid in 22 ...
Varma P K - - 1982
Many reports have now confirmed the teratogenic potential of alcohol in humans and in laboratory animals. A characteristic pattern of congenital anomalies is present in infants born to mothers suffering from chronic alcoholism. The pathogenesis of this condition is unclear. Chronic consumption of ethanol causes a depletion of essential fatty ...
Nubé M - - 1982
During parenteral nutrition without fat, biochemical changes in fatty acid composition of serum lipids may occur, such as a decrease in the concentration of linoleic and arachidonic acid and an increase of 5,8,11-eicosatrienoic acid. In various reports on essential fatty acid deficiency in parenteral nutrition, the rates and degrees of ...
Odutuga A A - - 1982
1. Nineteen-day old female weanling rats were maintained on diets deficient in essential fatty acids, low in zinc (6 p.p.m.) or both deficient in essential fatty acids and low in zinc; the weights of their brains were 25.6, 35.0 and 43.2% respectively, less than those of rats on control diets. ...
Friedman H I - - 1982
The essential fatty acids, particularly arachidonic, are important components of intracellular membrane systems. Their absence during dietary manipulation has been postulated to cause alterations in both composition and function of membranes and associated enzyme systems. In the current investigation, the effect of essential fatty acid deficiency on the induction of ...
Cederbaum S D - - 1982
A brother and sister aged 11 and 17 years have been reported previously to have hyperargininaemia and arginase deficiency: they were treated with a semi-synthetic diet consisting of fat, carbohydrate, minerals, vitamins and essential amino acids in amounts equivalent to 0.55-0.65 g protein kg-1 day-1 for 2 years. Plasma arginine ...
Van der Westhuyzen J - - 1982
1. Synaptosomes were prepared from the brain of cobalamin deficient and cobalamin supplemented fruit bats (Rousettus aegyptiacus) by a floatation method on a discontinuous sucrose gradient. 2. There were no significant differences in fatty acid composition between the deficient and supplemented bats. 3. The odd chain fatty acid 15:0 amounted ...
Castledine A J - - 1982
1. The turnover of rainbow trout (Salmo gairdneri) lipid was monitored in fish receiving essential fatty acids (EFA) replete and EFA deficient diets using [1-14C]-linolenic acid (C18:3 omega 3). 2. Forty percent of administered radioactivity was recovered in total lipid after 7 days. 3. Eighty-five percent of incorporated label was ...
Rosing U - - 1982
A hospitalized woman with essential hypertension complicated by severe preeclampsia was serially studied in the end of her pregnancy and in the puerperal period. The relative composition of serum lecithin fatty acids was analyzed by gas-liquid chromatography. In the present case, the main finding during pregnancy was a dramatic decrease ...
El-Zeany B A - - 1982
The composition of two varieties of Yeheb seeds (Moqley and Suley) was studied. The Suley variety shows somewhat higher protein and fat contents than the Moqley variety. Yeheb seed protein is rich in the essential amino acids lysine and arginine, but deficient in tryptophan and isoleucine. The component fatty acids ...
De Schrijver R - - 1982
Studies are reported on the effects of dietary trans fatty acids on the 6- and 9-acyl desaturase activities in the liver microsomes of rats fed essential fatty acid (EFA)-deficient and non-EFA-deficient diets. In experiment I, weanling male rats were fed a semisynthetic diet with either 10% safflower oil (SAF) or ...
Hernell O - - 1982
The aim of the present study was to examine the fatty acid patterns of plasma phospholipids, cholesteryl esters, triglycerides and free fatty acids in patients with Sjögren-Larsson syndrome in order to detect whether absorption or metabolism is essential fatty acids may be abnormal. The fatty acid patterns were analyzed by ...
McCarthy M C - - 1981
Plasma fatty acid profiles of 33 critically ill surgical patients receiving fat-free parenteral nutrition were examined at weekly intervals up to 28 days. While plasma total fatty acid concentration remained relatively constant and within the normal range, marked compositional alterations were apparent. Levels of linoleate (18:2 omega 6), the major ...
Milner R D - - 1981
Fetal rat pancreatic rudiments explanted on day 14 of gestation were grown for 6 days in organ culture in medium containing glucose (5.5 or 16.5 mmol/l) and essential amino acids (3.5 or 13.1 mmol/l). Non-essential amino acids (alanine, aspartic acid, asparagine, glycine, proline and serine) were added to the culture ...
Sweetman L - - 1981
Dietary deficiency of biotin was documented in an 11-year-old retarded boy as a consequence of a dietary prescription containing raw eggs. Clinical manifestations were alopecia totalis and an erythematous, exfoliative dermatosis. Metabolic characteristics included increased excretion of 3-methylcrotonylglycine, 3-hydroxyisovaleric acid, 3-hydroxypropionic acid, methylcitric acid, and lactic acid, as well as ...
Balint J A - - 1981
lung slices from rats fed a fat-free diet supplemented with safflower oil (control) or tripalmitoylglycerol (essential fatty acid [EFA]-deficient) were incubated with [14C]acetate, [14C]palmitate, or [14C]stearate. Of the 14C recovered in phospholipids after incubation with [14C]acetate, more than 87% was in 16-carbon fatty acids. Desaturation, as assayed by the percentage ...
McCarty M F - - 1981
The preventive merits of "nutritional insurance" supplementation can be considerably broadened if meaningful doses of nutrients such as mitochondrial "metavitamins" (coenzyme Q, lipoic acid, carnitine), lipotropes, and key essential fatty acids, are included in insurance supplements. From the standpoint of cardiovascular protection, these nutrients, as well as magnesium, selenium, and ...
Menon N K - - 1981
Prolonged dietary deprivation is needed to produce essential fatty acid (EFA) deficiency. But lack of EFA also impairs reproductive function. Inclusion of small amounts of linoleic acid in the diet can overcome this difficulty; further, if large amounts of oleic acid are included in the diet, this competes with the ...
Sinclair A J - - 1981
1. There is controversy regarding the capacity of the cat to convert 18: 2 omega 6 to 20: 4 omega 6 and the ability of the essential fatty acid (EFA)-deficient cat to produce 20: 3 omega 9. 2. This paper reports the isolation and identification of 20: 3 omega 9 ...
Erlichman M - - 1981
The allegedly beneficial effect of biotin in the treatment of infantile 'flexural' seborrhoeic dermatitis was evaluated in a double-blind controlled study. No beneficial effect could be confirmed, and it is therefore unlikely that this disease is caused by biotin deficiency. Nor could this scaly dermatitis be ascribed to an essential ...
Ehrström M - - 1981
Erythrocyte membranes from rats raised on a diet with low content of essential fatty acids were studied by osmotic sensitivity tests and spin labeling techniques. This diet induced significant modifications in acylglycerophosphocholine fatty acid composition with regard to 16 : 1, 18 : 1, 18 : 2 (n-6), 20 : ...
Tiruppathi C - - 1981
Previous studies indicated that many patients with tropical sprue in southern India have triglyceride accumulation within the cells of the intestinal mucosa. This could be due to essential fatty acid deficiency as a result of steatorrhea in subjects on a diet normally low in linoleic acid. Plasma lipids have, therefore, ...
De Bruyn J - - 1981
Mycobacterium tuberculosis var. bovis (BCG) grown on Sauton medium normally forms a pellicle; in the absence of added Zn2+, however, the pellicle sank during incubation and the yield was only about 20% of normal. The Zn2+-starved bacteria were morphologically similar to normal bacteria and were still acid-fast at 7 d ...
Chandrabose K A - - 1981
A clone of L1210 mouse leukemia cells selected for resistance to both the antiviral and anticellular properties of mouse interferon were essentially devoid of fatty acid cyclooxygenase activity. Experiments in which broken cell preparations were mixed or the two cell types were cultivated together failed to indicate the presence of ...
Shanske S - - 1981
The activities of acid and neutral maltase were measured in lymphocytes, granulocytes, and platelets isolated from controls and from 5 patients with late-onset acid maltase deficiency (AMD). Lymphocytes from patients had markedly decreased activity of acid maltase and elevated neutral/acid ratios. In granulocytes, acid maltase was also lower than in ...
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