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Chao Hung-hsing - - 2008
AIM: Recent experimental and human studies have shown that hyperuricemia is associated with hypertension and cardiovascular diseases. Elevated levels of endothelin-1 (ET-1) has been regarded as one of the most powerful independent predictors of cardiovascular diseases. For investigating whether uric acidinduced vascular diseases are related to ET-1, the uric acid-induced ...
Shamitha G - - 2008
The tasar silkworm, Antheraea mylitta Drury, Andhra local ecorace is an exclusive race of Andhra Pradesh. It is on the verge of extinction due to difficulty of acclimatisation at breeding and rearing stages. As an attempt to protect this race, a method of total indoor rearing has been done. In ...
Menè Paolo - - 2008
In humans, uric acid is the main urinary metabolite of purines. Serum levels are higher compared with other mammalians. Uric acid is an antioxidant and perhaps helps to control blood pressure during a low Na+ diet through stimulation of the renin-angiotensin system. Serum uric acid is also considered a marker ...
Gasse P - - 2008
Introduction: Lung injury leads to pulmonary inflammation and fibrosis through myeloid differentiation primary response gene 88 (MyD88) and interleukin-1 receptor 1 (IL-1R1) signalling pathway (J Clin Invest, 2007, 117: 3786-3793). However, the molecular mechanisms by which lung injury triggers IL-1beta production, inflammation and fibrosis remain poorly understood. Based on the ...
Chiwa Masaaki - - 2008
We analyzed low molecular weight organic acids and aldehydes in throughfall under pine forest, and organic acids in dew on chemically inert surfaces and pine needle surfaces at urban- and mountain-facing sites of pine forest in western Japan. Low molecular weight organic acids and aldehydes accounted for less than 5% ...
Cheng Tzu-Hurng - - 2010
BACKGROUND: The association between hyperuricemia and cardiovascular diseases has long been recognized. Elevated levels of uric acid may have a causal role in hypertension and cardiovascular diseases. However, the direct effect of uric acid on cardiac cells remains unclear. Therefore, this study was aimed to examine the effect of uric ...
Tlak, Ivana; Department of ...
The effect of a six-day fasting period on the variations of total protein and uric acid concentrations as well as on the activities of aspartate aminotransferase [aspartate:2-oxoglutarate aminotransferase (AST); EC 2.6.1.1] and alanine aminotransferase [L-alanine:2-oxoglutarate aminotransferase (ALT); EC 2.6.1.2] was investigated in Peking Duck ducklings. At the age of 28 ...
Balakumar Pitchai - - 2008
The study has been designed to investigate the effect of benfotiamine, a thiamine derivative, in nicotine and uric acid-induced vascular endothelial dysfunction (VED) in rats. Nicotine (2 mg kg(-1)day(-1), i.p., 4 weeks) and uric acid (150 mg kg(-1)day(-1), i.p., 3 weeks) were administered to produce VED in rats. The development ...
Xue Ruyi - - 2008
The purpose of this study was to investigate the serum metabolic difference between hepatocellular carcinoma (HCC, n = 20) male patients and normal male subjects (n = 20). Serum metabolome was detected through chemical derivatization followed by gas chromatography/mass spectrometry (GC/MS). The acquired GC/MS data was analyzed by stepwise discriminant ...
Sarvary Mark A - - 2008
Environmental conditions during egg and larval development may influence the dispersal ability of insect pests, thus requiring seasonal adjustment of control strategies. We studied the longest single flight, total distance flown, and the number of flights initiated by wild Cactoblastis cactorum (Berg) (Lepidoptera: Pyralidae) to determine whether the flight performance ...
Dehghan Abbas A Department of Epidemiology, Erasmus Medical Centre, Rotterdam, - - 2008
Hyperuricaemia, a highly heritable trait, is a key risk factor for gout. We aimed to identify novel genes associated with serum uric acid concentration and gout. Genome-wide association studies were done for serum uric acid in 7699 participants in the Framingham cohort and in 4148 participants in the Rotterdam cohort. ...
Liao Wei-Yin - - 2008
The detection and quantification of triglyceride (TG) using an iridium nano-particle modified carbon based biosensor was successfully carried out in this study. The detection procedures were based on the electrochemical detection of enzymatically produced NADH. TG was hydrolyzed by lipase and the glycerol produced was catalytically oxidized by NAD-dependent glycerol ...
Herrmann-Hoesing Lynn M - - 2008
Previous studies initiated defining the role of host genetics in influencing the outcome of exposure to ovine progressive pneumonia virus. However, specific genes influencing host control of virus replication and disease progression have not been identified. This study, using 383 ewes of the Columbia, Polypay, and Rambouillet breeds, tested the ...
Schlesinger Ilana - - 2008
Recent studies have provided evidence that uric acid may play a role in the development and progression of Parkinson's disease (PD). Uric acid is a natural antioxidant that may reduce oxidative stress, a mechanism thought to play a role in the pathogenesis of PD. Higher levels of serum urate (SU) ...
Jang Won Cheoul - - 2008
It has been suggested that the SLC22A12 gene polymorphism may be involved in the mechanism of renal urate handling. The purpose of the current study was to identify the effect of the T6092C polymorphism of the SLC22A12 gene on serum uric acid concentrations in the Korean population. We examined 196 ...
Li Xuemei - - 2008
The accumulation of perfluorinated compounds (PFCs) in the sera of captive wildlife species Bengal tigers (Panthera tigris tigris) and African lions (Panthera leo Linnaeus) from Harbin Wildlife Park, Heilongjiang Province, in China were analyzed by high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). Perfluorooctanesulfonate (PFOS) was the predominant contaminant with a mean ...
Nalbandyan Vladimir B - - 2008
Although X-ray diffraction (XRD) is the most reliable method for analysis of urinary stones, it has its specific limitations. It fails to detect amorphous phases, cannot distinguish between chemically different phases having identical lattice geometry (e.g., brushite CaHPO4.2H2O and gypsum CaSO4.2H2O) and may miss some phases (e.g., apatite and calcium ...
McArdle Patrick F PF University of Maryland School of Medicine, Baltimore, MD 21201, - - 2008
Uric acid is the primary end product of purine metabolism. Increased serum uric acid levels have been associated with gouty arthritis as well as with a variety of cardiovascular-related phenotypes. This study was undertaken to investigate associations between uric acid levels and single-nucleotide polymorphisms (SNPs). A 500,000-SNP genome-wide association study ...
Gonzalez-Gay Miguel A - - 2009
OBJECTIVE: To establish whether serum uric acid concentration correlates with carotid intima-media wall thickness (IMT) in a cohort of psoriatic arthritis (PsA) patients without overt cardiovascular (CV) disease or classic CV risk factors who attended a community hospital. METHODS: A series of 52 PsA patients were assessed by carotid ultrasonography. ...
Wang Zhouping - - 2009
It was found that the mixing of CdTe semiconductor nanocrystals (NCs) with luminol in the presence of KMnO(4) can induce a great sensitized effect on chemiluminescence (CL) emission. When the concentration of luminol, KMnO(4) and NaOH were fixed at 1 microM, 1 microM and 0.05 M, respectively, the most excellent ...
Ward R Parker - - 2008
BACKGROUND AND PURPOSE: Carotid intima-media thickness (CIMT) is associated with systemic atherosclerosis and cardioembolic conditions and predicts the risk of recurrent strokes. We sought to establish the relationship between CIMT and cardiovascular sources of embolus (CSE) on transesophageal echocardiography (TEE) and hypothesized that a noninvasive strategy of CIMT assessment and ...
Shin Jae Ho JH Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, - - 2008
An amperometric fluorinated xerogel-derived nitric oxide (NO) microelectrode is described. A range of fluorine-modified xerogel polymers were synthesized via the cohydrolysis and condensation of alkylalkoxy- and fluoroalkoxysilanes. Such polymers were evaluated as NO sensor membranes to identify the optimum composition for maximizing NO permeability while providing sufficient selectivity for NO ...
Schrenkhammer Petra - - 2008
An optical biosensor is presented for continuous determination of uric acid. The scheme is based on the measurement of the consumption of oxygen during the oxidation of uric acid that is catalyzed by the enzyme uricase. The enzyme is immobilized in a polyurethane hydrogel next to a metal-organic probe whose ...
Welk Blayne K - - 2008
We report 2 patients who presented with uric acid renal calculi. Both patients had previously been treated unsuccessfully for their stones with shock wave lithotripsy and were referred to our centre for percutaneous nephrolithomy. We were able to avoid surgery in both cases owing to the recognition of uric acid ...
Yoo Hoon - - 2008
Concentrations of perfluoroalkyl acids (PFAs) were measured in egg yolks of three species of birds, the little egret (Egretta garzetta), little ringed plover (Charadrius dubius), and parrot bill (Paradoxornis webbiana), collected in and around Lake Shihwa, Korea, which receives wastewaters from an adjacent industrial complex. Mean concentrations of perfluorooctanesulfonate (PFOS) ...
Johnson Richard J RJ Division of Nephrology, Hypertension and Transplantation, University of Florida, Gainesville, FL 32610, USA. - - 2009
Uric acid has historically been viewed as a purine metabolic waste product excreted by the kidney and gut that is relatively unimportant other than its penchant to crystallize in joints to cause the disease gout. In recent years, however, there has been the realization that uric acid is not biologically ...
Dimitroula Hariklia V - - 2008
BACKGROUND: Although in the past decade a large number of studies have been performed to identify the relationship between uric acid and stroke, the issue remains unresolved and it is not clear whether the correlation between uric acid and stroke is circumstantial or causal. REVIEW SUMMARY: Some studies have found ...
Taki Hisashi - - 2008
Pyrazinamide is an antituberculous drug that is administered as a two-month course during treatment of pulmonary tuberculosis. Adverse reactions to pyrazinamide have been reported to include hyperuricemia. We performed a retrospective multicenter epidemiological survey to assess the relationship between various patient characteristics and the uric acid level, the changes of ...
Jin Guan-Ping - - 2008
The electrochemical modification of clenbuterol (CLB) was studied at paraffin-impregnated graphite electrode (WGE) in two potential ranges of 0.0-1.6V and -1.2 to 1.2V. Various methods including X-ray photoelectron spectroscopy (XPS), UV-spectroelectrochemistry, infrared (IR) spectra and electrochemical techniques have been used to characterizing the modification. Clenbuterol can be modified at the ...
Löfstrand Karin - - 2008
Polyfluorinated alkyl compounds (PFCs) are a group of chemicals of growing concern that have been detected in biological and abiotic samples worldwide. This study reports the concentrations of a suite of PFCs: perfluorooctyl sulfonate (PFOS), perfluorooctyl sulfonamide (PFOSA) and perfluorinated carboxylic acids (PFCAs) in guillemot (Uria aalge) eggs, collected in ...
Zhang Lei - - 2008
A composite film of polyaniline (PAN) nano-networks/p-aminobenzene sulfonic acid (ABSA) modified glassy carbon electrode (GCE) has been fabricated via an electrochemical oxidation procedure and applied to the electro-catalytic oxidation of uric acid (UA) and ascorbic acid (AA). The ABSA monolayer at GCE surface has been characterized by X-ray photo-electron spectroscopy ...
Alcaino Hernan - - 2008
Increased serum uric acid has been identified as an independent risk factor for cardiovascular disease. However, because of its antioxidant capacity, uric acid may play a beneficial role in endothelial function. This paradoxical relationship between uric acid and endothelial function in chronic heart failure patients remains poorly understood. Thirty-eight chronic ...
Huang Jianshe - - 2008
Palladium nanoparticle-loaded carbon nanofibers (Pd/CNFs) were prepared by electrospinning and subsequent thermal treatment processes. Pd/CNFs modified carbon paste electrode (Pd/CNF-CPE) displayed excellent electrochemical catalytic activities towards dopamine (DA), uric acid (UA) and ascorbic acid (AA). The oxidation overpotentials of DA, UA and AA were decreased significantly compared with those obtained ...
Bertrand Kouam Eric - - 2008
Oxidative stress and changes in antioxidant status have been implicated in the pathogenesis of malaria. To assess the antioxidant level ofbilirubin and uric acid associated with falciparum malaria infection, 60 untreated patients (30 men and 30 women) in Douala, Cameroon were screened for the study. Sixty five healthy individuals (29 ...
Horwath-Winter Jutta - - 2009
PURPOSE: The aim of this investigation was to assess and compare levels of uric acid in human tear fluid, aqueous humour and serum in cataract patients in order to obtain information about uric acid-dependent antioxidative status. METHODS: Reflex tear fluid, aqueous humour and serum were obtained from 103 cataract patients ...
Wang P - - 2008
Phthalic acid esters (PAEs) are used in many branches of industry and are produced in huge amounts throughout the world. An investigation on particulate- and gas-phase distribution of PAEs has been conducted in Nanjing (China). The 12-h daily sampling program (from 8:00 am to 8:00 pm) for ten consecutive days ...
Kasparová M - - 2008
The important substances of secondary metabolism include flavonoids and isoflavonoids. The Trifolium pratense L. (Fabaceae) suspension culture's yield of these metabolites is low, thus an attempt was made to increase the production by elicitation. The endogenous signal substances of the plants' defensive responses include jasmonic acid that also functions as ...
Torres R J - - 2008
We have studied 36 patients with HPRT deficiency, 25 with Lesch-Nyhan syndrome and 11 with partial HPRT deficiency (grades 1 to 3). Patients diagnosed with HPRT deficiency have increased 50% since 2000. The most relevant recent advances have been made in molecular diagnosis. Nevertheless, enzyme determinations are still essential for ...
Yoder J A - - 2008
Response to tick-exposed filter paper discs (tick excreta) by fed and non-fed stages of the lone star tick Amblyomma americanum (L.) (Acari: Ixodidae) was examined from larva to adult. By contrast with engorged stages, each non-fed stage exhibited a classic arrestment response to assembly pheromone, characterized by lack of movement, ...
Bo S - - 2008
AIM: Serum uric acid is associated with the metabolic syndrome and its components, while its relationship with cardiovascular disease is controversial. The aim of the study was to evaluate the association between uric acid and adipokines, markers of inflammation, oxidative stress, and endothelial dysfunction, which are all linked to cardiovascular ...
Montoya F - - 2008
This report describes a 75-year-old Caucasian man with extensive urate deposits and severe gouty arthropathy that confined him to a wheelchair. Since age 50, he suffered multiple acute gout flares and progressive deformities in his hands, feet, knees, and elbows (tophi). Serum creatinine was 1.4 mg/dL and serum urate 9.4 ...
Ciari I - - 2008
Free radical excess and oxidative stress are implicated in the formation and progression of atherosclerotic plaque through actions on susceptible vascular cells, such as by activating xanthine oxidase. Purine bases and other antioxidant compounds could play important protective roles in atherogenesis, as could nonenzymatic low molecular weight thiol defenses, not ...
Sautin Yuri Y YY Division of Nephrology, Hypertension and Transplantation, Department of Medicine, University of Florida, Gainesville, Florida 32610-0224, - - 2008
Uric acid, despite being a major antioxidant in the human plasma, both correlates and predicts development of obesity, hypertension, and cardiovascular disease, conditions associated with oxidative stress. While one explanation for this paradox could be that a rise in uric acid represents an attempted protective response by the host, we ...
Bao Huiming - - 2008
Understanding the composition of the atmosphere over geological time is critical to understanding the history of the Earth system, as the atmosphere is closely linked to the lithosphere, hydrosphere and biosphere. Although much of the history of the lithosphere and hydrosphere is contained in rock and mineral records, corresponding information ...
Simão Andréa Name Colado - - 2008
OBJECTIVE: Metabolic syndrome (MS) is a cluster of risk factors for cardiovascular disease related mainly to insulin resistance, but also to oxidative stress. Uric acid and gamma-glutamyltransferase (GGT) levels are also associated with MS and oxidative stress. This study was undertaken to assess the role of GGT and uric acid ...
Gagliardi Ana C M - - 2009
The relationship between uric acid and cardiovascular disease has been known since the 19th century, after that many authors reported the classical association of gout, hypertension, obesity and cardiovascular disease. With the exception of specific genetic defects in purine metabolism, increased uric acid is generally associated with important risk factors ...
O'Mullane Anthony P - - 2008
An analytical evaluation of the higher ac harmonic components derived from large amplitude Fourier transformed voltammetry is provided for the reversible oxidation of ferrocenemethanol (FcMeOH) and oxidation of uric acid by an EEC mechanism in a pH 7.4 phosphate buffer at a glassy carbon (GC) electrode. The small background current ...
Brandstätter Anita - - 2008
High serum uric acid levels lead to gout and have been reported to be associated with an increased risk of hypertension, obesity, metabolic syndrome, type 2 diabetes, and cardiovascular disease. Recently, the putative fructose transporter SLC2A9 was reported to influence uric acid levels. The aim of the present study was ...
Bagherzadeh Ali - - 2008
To investigate the effect of silvicultural methods on forest floor C, N and elements stocks an experiment was carried out by sampling the forest floors of a 100-120-years-old species including beech, Norway spruce and mixed beech-spruce at the Solling forest, Germany. While the stocks of carbon and nitrogen in the ...
Kostiainen Katri - - 2008
We investigated the interactive effects of elevated concentrations of carbon dioxide ([CO(2)]) and ozone ([O(3)]) on radial growth, wood chemistry and structure of five 5-year-old trembling aspen (Populus tremuloides Michx.) clones and the wood chemistry of paper birch (Betula papyrifera Marsh.). Material for the study was collected from the Aspen ...
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