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Fazil Marickar Y M - - 2009
Several modalities of stone analysis are utilised in different laboratories. However, the treating clinician finds it hard to assess the initiation and progression of stone formation. The pathogenesis of calculogenesis still remains a mystery. The purpose of this paper is to assess the pathological mechanisms of stone nucleation and growth ...
Poyrazo─člu Hakan M - - 2009
BACKGROUND: Determining uric acid : creatinine ratios in random urine samples may be useful to assess the excretion of uric acid in children. Because it was shown that urinary uric acid excretion varies with age and geographic area, it is important to have accurate reference values of uric acid excretion. ...
Zhao Changzhi - - 2009
A uric acid biosensor based on the direct electron transfer of a hemoglobin-encapsulated chitosan-modified glassy carbon electrode was developed for a highly sensitive and selective analysis in urine samples. The modified electrode was prepared by the encapsulation of hemoglobin and uricase in a chitosan matrix. The hydrogen peroxide produced from ...
Basu Pallab - - 2009
OBJECTIVE: Study of uric acid level in spot urine of normal preterm AGA (appropriate for gestational age) babies in day one of their life. METHODS: Spot urine samples were collected from 45 normal preterm neonates within 24 hours of their birth for estimation of uric acid. RESULTS: The mean uric ...
Tausche Anne-Kathrin - - 2009
Because of the changing dietary habits of an aging population, hyperuricemia is frequently found in combination with other metabolic disorders. Longstanding elevation of the serum uric acid level can lead to the deposition of monosodium urate crystals, causing gout (arthritis, urate nephropathy, tophi). In Germany, the prevalence of gouty arthritis ...
Alwarappan Subbiah - - 2010
In this work we have evaluated the performance of electrochemically pretreated single-walled carbon nanotubes (SWCNTs) toward the electrochemical detection of dopamine in the presence of ascorbic acid and uric acid at physiological pH. Results indicated that the electrochemically pretreated SWCNTs showed a selective and enhanced electroanalytical response with minimal electrode ...
Fazil Marickar Y M - - 2009
Cystine stones are produced by an inherited disorder of the transport of amino acid cystine that results in excess of cystine in the urine (cystinuria). Cystine calculi in urinary tract present a significant problem in patients. We have recorded that cystine calculi are very uncommon in our region. Cystine crystals ...
Voruganti V Saroja VS Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78245-0549, USA. - - 2009
Hyperuricemia is associated with the metabolic syndrome, gout, renal and cardiovascular disease (CVD). American Indians have high rates of CVD and 25% of individuals in the strong heart family study (SHFS) have high serum uric acid levels. The aim of this study was to investigate the genetic determinants of serum ...
Suzuki Toshinori - - 2009
Uric acid of human plasma concentration accelerated nitrosation of N-acetylcysteine by diethylamine NONOate at neutral pH, but diminished that of N-acetyltryptophan. Uric acid also accelerated nitrosation of N-acetylcysteine by N-acetyl-N-nitrosotryptophan, having a nitroso group on the nitrogen atom of the indole ring. N-Acetyl-S-nitrosocysteine was stable even in the presence of ...
Hillis Graham S - - 2009
OBJECTIVE: Elevated uric acid levels have been associated with an adverse cardiovascular outcome in several settings. Their utility in patients undergoing surgical revascularization has not, however, been assessed. We hypothesized that serum uric acid levels would predict the outcome of patients undergoing coronary artery bypass grafting. METHODS: The study cohort ...
Doblado Manuel A - - 2009
GLUT9 is a novel, facilitative glucose transporter isoform, which exists as two alternative splice variants encoding two proteins that differ in their N-terminal sequence (GLUT9a and GLUT9b). Both forms of GLUT9 protein and mRNA are expressed in the epithelia of various tissues, however the two splice variants are expressed differentially ...
Keizman D - - 2009
BACKGROUND: The exact cause of amyotrophic lateral sclerosis (ALS) is unknown. Oxidative stress is one of the factors implicated in the etiology of ALS as well as in that of other neurodegenerative diseases. Uric acid is an important natural antioxidant that may reduce oxidative stress. The objective of this study ...
Koopmans Corine M - - 2009
The aim of this study is to determine the accuracy and clinical value of serum uric acid in predicting maternal complications in women with pre-eclampsia. An existing meta-analysis on the subject was updated. The accuracy of serum uric acid for the prediction of maternal complications was assessed with a bivariate ...
Arora Jyoti - - 2009
Uricase purified from 20-day-old leaves of cowpea was immobilized on to epoxy resin membrane with 80% retention of initial activity of free enzyme and a conjugation yield of 0.056 mg/cm(2). The uricase epoxy resin bioconjugate membrane was mounted over the sensing part of the combined electrode of 'Aqualytic' dissolved O(2) ...
Ahaneku J E - - 2009
Serum uric acid and urea levels were determined in 27 pregnant and 17 non-pregnant black African women. Uric acid levels for the pregnant women were significantly raised, and the relationship between uric acid elevation and gestational proteinuric hypertension was discussed. In conclusion, we recommend that uric acid estimation should be ...
Kolz Melanie M Institute of Epidemiology, Helmholtz Zentrum München, National Research Center for Environment and Health, Neuherberg, - - 2009
Elevated serum uric acid levels cause gout and are a risk factor for cardiovascular disease and diabetes. To investigate the polygenetic basis of serum uric acid levels, we conducted a meta-analysis of genome-wide association scans from 14 studies totalling 28,141 participants of European descent, resulting in identification of 954 SNPs ...
Bousov?? Iva - - 2009
Glycation is a process closely related to the aging and pathogenesis of diabetic complications. Reactive alpha-dicarbonyl compounds (e.g., methylglyoxal) are formed during middle stage of glycation reaction. Compounds that would inhibit the glycation process have been seeked for years. The objective of this study was to investigate the inhibitory effect ...
Kalimuthu Palraj - - 2009
The present study reports the simultaneous determination of ascorbic acid (AA), dopamine (DA) and uric acid (UA) in 0.20 M phosphate buffer solution (pH 5.0) using electropolymerized ultrathin film of 5-amino-2-mercapto-1,3,4-thiadiazole (AMT) on glassy carbon (GC) electrode. The bare GC electrode does not separate the voltammetric signals of AA, DA ...
Hovind Peter - - 2009
OBJECTIVE: Experimental and clinical studies have suggested that uric acid may contribute to the development of hypertension and kidney disease. Whether uric acid has a causal role in the development of diabetic nephropathy is not known. The objective of the present study is to evaluate uric acid as a predictor ...
Amorini Angela M - - 2009
In this study, the concentrations of uric acid, purine profile and creatinine in samples of cerebrospinal fluid and serum of multiple sclerosis (MS) patients were measured by HPLC and compared with corresponding values recorded in patients without MS (cerebrospinal fluid) and healthy subjects (serum). All samples were deproteinized with ultrafiltration ...
El Bouhouti H - - 2009
The Sonogel-Carbon electrode is a special class of sol-gel electrode that exhibits favourable mechanic and electric properties to be used as electrochemical sensor. In this study, Sonogel-Carbon modified with L-Cysteine was used to prepare a novel electrochemical sensor. The objective of this novel electrode modification was to seek new electrochemical ...
Rule Andrew D AD Division of Nephrology and Hypertension, Division of Biostatistics, Mayo Clinic, Rochester, MN, USA. - - 2009
Uric acid is heritable and associated with hypertension and insulin resistance. We sought to identify genomic regions influencing serum uric acid in families in which two or more siblings had hypertension. Uric acid levels and microsatellite markers were assayed in the Genetic Epidemiology Network of Arteriopathy (GENOA) cohort (1075 whites ...
Edwards N Lawrence - - 2009
PURPOSE OF REVIEW: The role of uric acid as a mediator of vascular damage is not a new idea but has only recently gained widespread acceptance. Uric acid has previously been viewed as a benign solute in serum until it exceeds its saturation level. Others have viewed it as an ...
Kanevets Uliana U Immunology Research Group and Department of Microbiology and Infectious Diseases, University of Calgary, Calgary, Alberta, - - 2009
Uric acid is released from injured cells and can act as an adjuvant signal to the immune system. Uric acid crystals invoke strong inflammatory responses in tissues. Although their biological effects are evident and the associated signaling mechanisms are becoming clear, it remains unexplained as to why uric acid precipitates ...
Alatalo Päivikki I - - 2009
Uric acid seems to be causally involved in a variety of medical disorders involving oxidative stress. Although alcohol abuse and obesity are known to increase serum uric acid, the interactions between moderate drinking, adiposity, and uric acid metabolism have remained poorly understood. We examined serum uric acid concentrations from 2062 ...
Park Bohyun - - 2009
Recent studies suggest that uric acid plays a causal role in the development of hypertension in relation to birth weight. The aim of the study was to elucidate the effect of prenatal and/or postnatal growth status on serum uric acid levels in children at 3 years of age. A total ...
Gasse Pamela P University of Orleans and CNRS, Orleans, - - 2009
Lung injury leads to pulmonary inflammation and fibrosis through myeloid differentiation primary response gene 88 (MyD88) and the IL-1 receptor 1 (IL-1R1) signaling pathway. The molecular mechanisms by which lung injury triggers IL-1beta production, inflammation, and fibrosis remain poorly understood. To determine if lung injury depends on the NALP3 inflammasome ...
Cirillo Pietro - - 2009
Increased consumption of fructose may play an important role in the epidemic of metabolic syndrome and may presage the development of diabetes, cardiovascular disease, and chronic kidney disease. Once in the cell, fructose is phosphorylated by ketohexokinase (KHK), leading to consumption of ATP, formation of AMP, and generation of uric ...
Bellanato Juana - - 2009
To investigate the presence of calcium urate, sodium, potassium and calcium in 'pure' uric acid calculi. Ten spontaneously passed uric acid urinary calculi have been examined by stereoscopic microscopy, infrared spectroscopy, scanning electron microscopy and energy dispersive X-Ray analysis. The analysis of selected uric acid calculi revealed the presence of ...
Li Youming - - 2009
Serum uric acid level has been suggested to be associated with factors that contribute to the metabolic syndrome. The aim of this study was to investigate the association of serum uric acid level with non-alcoholic fatty liver disease (NAFLD). A cross-sectional study was performed among the employees of Zhenhai Refining ...
Li Wei-Ming - - 2009
AIM: The aim of this study was to evaluate the clinical characteristics of uric acid urolithiasis and how the presentation differs between urolithiasis of the upper urinary tract (UUT) compared with urolithiasis of the bladder. We attempted to evaluate the importance of local vs. systemic factors in the formation of ...
Nogueira Ana - - 2009
A 56-year-old woman presented with a 6 month history of bullae and whitish plaques of the fingers. She had chronic renal failure, but no joint pains or evidence of arthritis. An aspirate of fluid from a bulla revealed uric acid crystals and serum uric acid was elevated at 16.2 mg/dL. ...
Zabka T S - - 2009
Domoic acid, produced by marine algae, can cause acute and chronic neurologic sequela in California sea lions (Zalophus californianus) from acute toxicity or sublethal exposure. Eight sea lions, representing acute and chronic cases, both sexes, and all age classes, were selected to demonstrate a concurrent degenerative cardiomyopathy. Critical aspects of ...
Ejaz A Ahsan - - 2009
BACKGROUND: Uric acid has been reported to be a risk factor for the development of chronic kidney disease; however, no study has examined whether uric acid may confer a risk for acute kidney injury. METHODS: We investigated the relation between serum uric acid and the incidence of postoperative acute kidney ...
Papezikova Ivana - - 2009
OBJECTIVES: Elevated plasma uric acid indicates an increased risk of cardiovascular diseases associated with endothelial dysfunction. However, the role of uric acid in the pathogenesis of endothelial dysfunction is still a matter of debate. It is not clear whether uric acid is a real causative risk factor, an inert marker, ...
da Silva Silvia F R - - 2009
BACKGROUND: Urolithiasis is a common disease that is increasing throughout the world. This study aimed at determining the composition of urinary stones in patients with renal lithiasis in an emerging country. METHODS: A morphological analysis was performed on 340 urinary stones from 325 consecutive patients from Brazil with lithiasis. RESULTS ...
Hamer Henrike M - - 2009
BACKGROUND & AIMS: Butyrate, a short-chain fatty acid produced by colonic microbial fermentation of undigested carbohydrates, has been implicated in the maintenance of colonic health. This study evaluates whether butyrate plays a role in oxidative stress in the healthy colonic mucosa. METHODS: A randomized, double blind, cross-over study with 16 ...
Yang Liming - - 2008
This study systematically examined effects of analytical approaches on resultant concentrations of oxalic acid, oxalates, malonic acid, and malonates. Results demonstrated that employing separate water extraction and THF extraction is required to properly quantify dicarboxylic acids vs dicarboxylates using IC or GC-MS. Applications of the recommended methods to analyze PM2.5 ...
Thiagarajan Soundappan - - 2009
A glassy carbon electrode (GCE) has been modified by electrochemical oxidation in mild acidic media (0.1 mol l(-1) H(2)SO(4)) and could be applied for individual and simultaneous determination of ascorbic acid (AA), dopamine (DA) and uric acid (UA). Oxidized GCE shows a single redox couple (E(0)'=-2.5 mV) which is based ...
Ito Jun - - 2009
Acute kidney injury (AKI), mainly as a result of crush syndrome, is the second most common cause of death in large earthquakes. It is well known that AKI is preventable with early management (particularly with fluid therapy), but a means of determining which patients are at risk is needed. This ...
Shang Fengjun - - 2009
An effective and robust electrochemical approach has been developed for selective detection of dopamine in the presence of 3,4-dihydroxyphenylalanine (l-DOPA), ascorbic acid, uric acid and other dopamine metabolites. A 'layer-by-layer' film of tyramine and pyrrole-1-propionic acid (PPA) was formed by subsequent electropolymerization on a boron-doped diamond (BDD) electrode with an ...
Bainbridge S A SA Magee-Womens Research Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA. - - 2009
Hyperuricemia, a common clinical characteristic of preeclamptic pregnancies, has historically been considered a marker of reduced renal function in preeclamptic women. More recently it has been suggested that uric acid may directly contribute to pathological cell signaling events involved in disease progression as well as maternal and fetal pregnancy outcomes ...
Liu Ailin - - 2008
A novel uric acid electrochemical sensor was fabricated by electropolymerization on glassy carbon electrode (GCE) with 4-(2-pyridylazo)-resorcinol (PAR) and its electrochemical property was investigated through cyclic voltammetry. The effect of film thickness on the oxidation response was also studied by electropolymerized scan times. The voltammetric behavior of uric acid (UA) ...
Park E-J - - 2008
AIMS: To evaluate the efficacy of acidic electrolysed water (EW) in the presence of organic matter (bovine serum) on the inoculated surfaces of lettuce and spinach. MATERIALS AND RESULTS: Lettuce and spinach leaves were inoculated with a cocktail of three strains each of Escherichia coli O157:H7, Salmonella Typhimurium and Listeria ...
Mazloum-Ardakani Mohammad - - 2009
The redox response of a modified carbon nanotube paste electrode of 2,2'-[1, 2-ethanediylbis(nitriloethylidyne)]-bis-hydroquinone was investigated. Mixture of dopamine (DA) and uric acid (UA), can be separated from one another with a potential difference of 180 mV between them at a scan rate of 25 mVs(-1) by cyclic voltammetry. These conditions ...
Clode Peta L - - 2009
The symbiosis between cnidarians and dinoflagellate algae is not understood at the cell or molecular level, yet this relationship is responsible for the formation of thousands of square kilometres of coral reefs. We have investigated the nature of crystalline material prominent within marine algal symbionts of Aiptasia sp. anemones. This ...
Palazzi C - - 2009
In this article we describe a gouty caucasian male patient who had high levels of serum uric acid since 1970s. Serious adverse reactions to allopurinol discouraged its administration. We prescribed cyproterone acetate (CA) because of severe prostatic hypertrophy, associated with a suspect small cancer. The administration of this drug obtained ...
Voruganti V Saroja - - 2009
Elevated serum uric acid is associated with several cardiovascular disease (CVD) risk factors such as hypertension, inflammation, endothelial dysfunction, insulin resistance, dyslipidemia, and obesity. However, the role of uric acid as an independent risk factor for CVD is not yet clear. The aim of the study was to localize quantitative ...
Bensatal Ahmed - - 2008
The main objective is to study the inhibitor effect of acid fraction of the extract of Tamarix gallica L on the crystallization of calcium oxalate. The extract of Tamarix gallica L is very rich by acid compounds that are used as an inhibitor of nephrolithiasis (calcium oxalate). Our study of ...
Bird Michael I - - 2008
We report results obtained using a new technique developed to measure the stable-isotope composition of uric acid isolated from bird excreta (guano). Results from a diet-switch feeding trial using zebra finches suggest that the delta(13)C of uric acid in the guano equilibrates with the diet of the bird within 3 ...
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