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Akiyama K - - 1994
Two cases of atopic asthma caused by acid protease produced by Candida albicans are reported. Both patients had high levels of serum IgE antibodies against the acid protease and showed positive conjunctival and immediate bronchial responses when challenged with the protease. Significant histamine release was detected in both patients when ...
Coleman R F - - 1994
Twenty adult singers from one choral group were asked to produce sustained vowels and a short hymn sample while using three different dynamic levels: pianissimo, mezzoforte, and fortissimo. Large differences were found in total dynamic range among the subjects. Sustained vowels were slightly higher in output than was a song ...
Golden P L - - 1994
The effects of probenecid (2 gm) on the pharmacokinetics, pharmacodynamics, and uricosuric effects of adinazolam and N-desmethyladinazolam were assessed after single dose administration of adinazolam mesylate sustained-release tablets (60 mg) in a randomized, four-way crossover, double-blind study involving 16 healthy male volunteers. Probenecid decreased adinazolam oral clearance, renal N-desmethyladinazolam clearance, ...
Hogg R C - - 1994
1. The action of niflumic acid was studied on spontaneous and evoked calcium-activated chloride (ICl(Ca)) and potassium (IK(Ca)) currents in rabbit isolated portal vein cells. 2. With the nystatin perforated patch technique in potassium-containing solutions at a holding potential of -77 mV (the potassium equilibrium potential), niflumic acid produced a ...
de Brouwer B - - 1994
The authors report on a laboratory model for continuous production of human hair during long periods of time. This study shows that the amino acid composition of hairs collected in situ from human scalp was similar to that of terminal hairs produced by the donors' scalp follicles grafted and maintained ...
Garbagnati E - - 1994
Serum uric acid concentration and fractional excretion were evaluated in lean (n = 67) and obese (n = 56) girls before and during pubertal development. In both lean and obese girls, uricemia gradually increased as puberty advanced. Obese girls were hyperuricemic compared with lean controls (prepubertal: 184 +/- 83 v ...
Evander E - - 1994
We measured the pulmonary clearance of technetium-99m-labeled diethylenetriamine pentaacetatic acid (99mTc-DTPA) for 3 h after perturbation of the surfactant system by administration of the detergent dioctyl sodium sulfosuccinate in aerosol. Forty-two rabbits were anesthetized with pentobarbital sodium. Tracheostomies were performed, and the rabbits were mechanically ventilated. Increasing concentrations of detergent ...
Ross M A - - 1994
A simple method with excellent reproducibility has been developed for the simultaneous determination of the plasma concentration of ascorbic acid and uric acid by reversed-phase HPLC using an ion-pairing reagent with UV detection. Coefficients of variation for the concentrations of ascorbic acid and uric acid in plasma are < 2.1% ...
Omori N - - 1994
Of the eight patients with fulminant hepatitis placed under total parenteral nutrition with an amino acid solution rich in branched chain amino acids and treated by plasma exchange, four survived and four died from hepatic failure. Serum uric acid levels in the non-survived group were significantly lower on days 1-6 ...
Rojdev R - - 1994
The differential criterion-related validity of the MMPI and MMPI-2 and their stability over a 4-month period of time were examined in a university population by correlating the clinical scales with their counterpart SCL-90-R factors. Fair to moderate correlations were found on all eight paired MMPI scales and SCL-90-R factors, while ...
García Puig J - - 1994
Purine nucleotides are synthesized and degraded through a regulated series of reactions which end in the formation of uric acid. Increased uric acid synthesis may be the result of two major pathophysiological disorders: increased de novo purine synthesis and enhanced purine nucleotide degradation, both of which may be the result ...
Carey P D - - 1994
The production of chlorinated oxidants such as hypochlorous acid is a central antimicrobial and immunoregulatory function of neutrophils. Neutrophil hypochlorous acid production was compared in patients undergoing uncomplicated laparoscopic surgery (group 1) and those submitted to conventional open surgery (group 2). Preoperative peak hypochlorous acid production was similar in the ...
Duff A - - 1994
We have investigated further the anomalously high concentration of brain extracellular uric acid detected with in vivo sampling probes reported recently. The contribution by uric acid and 5-hydroxyindoleacetic acid (5-HIAA) to peak 2 recorded in rat striatum with chronically implanted carbon paste electrodes (CPEs) of different sizes was estimated by ...
Bartges J W - - 1994
Urine uric acid-to-urine creatinine ratios (UUA:UC), urine uric acid concentrations, urine uric acid concentrations corrected for glomerular filtration rate, and urinary uric acid fractional excretions were compared with 24-hour urinary uric acid excretions measured in 6 healthy adult female Beagles. Comparisons, using correlation analysis, were made when dogs consumed a ...
Ueda Y - - 1994
Cells of the retinal pigment epithelium (RPE) were isolated from neonatal rats. The perforated-patch clamp technique, using amphotericin-B, revealed a chloride current, which was detected as a 4,4'-diisothiocyanostilbene-2,2'-disulfonate (DIDS)-sensitive component. A variety of chloride-channel inhibitors, other than DIDS, also blocked the chloride current, including 9-anthracenecarboxylic acid (9-AC), niflumic acid, 5-nitro-2-(3-phenylpropylamino)-benzoic ...
Gandour M A - - 1994
The complex formation between uric acid and zinc, cadmium and lead ions has been investigated using differential pulse polarography in 0.01M NaNO(3). It is found that the complexes formed by Cd(II) and Pb(II) ions with uric acid have the stoichiometry of 1:2 and the logarithmic values of the apparent stability ...
Cai X - - 1994
Carbon paste electrodes, preanodized in alkaline medium at 1.4 V vs SCE for a short period of time, exhibit a great shift of the oxidation potential of uric acid in cathodic direction and a marked enhancement of its current response, compared to unpretreated electrodes. These effects are dependent on the ...
Siems W G - - 1994
Ten healthy subjects who swim regularly in ice-cold water during the winter (winter swimming), were evaluated before and after this short-term whole body exposure. A drastic decrease in plasma uric acid concentration was observed during and following the exposure to the cold stimulus. We hypothesize that the uric acid decrease ...
Jones M M - - 1994
Syntheses and relative cadmium mobilizing properties are described for three new monoaralkyl esters (HOOCCH(SH)CH(SH)COOR, where R = phenylethyl ((CH2)2C6H5), MPhEDMS; R = 3-phenylpropyl ((CH2)3C6H5), MPhPDMS; and R = 2-phenoxyethyl ((CH2)2OC6H5). MPhOEDMS) of meso-2,3-dimercaptusuccinic acid. These were prepared by the reaction of the corresponding alcohol with meso-2,3-dimercaptosuccinic acid (DMSA) in aqueous ...
Sebesta I - - 1994
Uric acid is the end product of purine metabolism in man. The findings of human pathological levels of uric acid in serum and urine have in most patients serious clinical implications. This paper summarizes aspects of uric acid examination in clinical biochemistry laboratory. The clinical consequences of pathological levels of ...
Suh H H - - 1994
Indoor acid aerosol, nitric acid (HNO3), and ammonia (NH3) concentrations were measured in 47 homes in State College, Pennsylvania, during the summer of 1991. From each home, 12-hour indoor, 12- and 24-hour outdoor, and 12-hour air exchange samples were collected continuously over a 5-day period. Additionally, questionnaires were administered daily ...
Adeola O - - 1994
Different extraction techniques were compared in uric acid analysis of avian excreta. These include five extraction reagents (0.1 M sodium hydroxide, 0.1 M glycine buffer, 0.068 m lithium carbonate, 0.136 M lithium carbonate and sodium borate buffer, pH 9.1). Each extraction reagent was used with four excreta sample weights (50,100,150 ...
Heering P - - 1994
We studied the renin-angiotensin system (RAS) and atrial natriuretic peptide (ANP) after amino acid loading in order to elucidate whether or not glomerular hyperfiltration is mediated by these hormones. Eight healthy controls without kidney disease (group 1), 8 renal graft recipients (group 2) and 8 patients after nephrectomy (group 3) ...
Male K B - - 1994
Water-soluble 2-hydroxypropyl-beta-cyclodextrin (Hp-beta-CyD), a cyclic and nonreducing oligosaccharide was used to enclose a hydrophobic guest molecule 1,1'-dimethylferrocene (DMF) to form a water-soluble yellow complex. At high concentrations (300 mM), Hp-beta-CyD enclosed up to 100 mM DMF. The yellow complex was electrochemically oxidized (platinum vs Ag/AgCl poised at +450 mV) to ...
Schiffman S S - - 1994
The purpose of this study was to quantify the degree of reduction in perceived bitterness by sweeteners at both threshold and suprathreshold concentrations of bitter compounds. Detection and recognition thresholds were determined for six bitter compounds (caffeine, denatonium benzoate, magnesium chloride, quinine hydrochloride, sucrose octaacetate, and urea) in the absence ...
Aarflot T - - 1994
In a previous article from a cross-sectional study of 737 men and 771 women (40-42 years old) in Norway, we found a higher mean serum uric acid in persons with than without chronic musculoskeletal complaints. Furthermore, the odds ratio for chronic complaints increased by increasing uric acid level. Persons with ...
Walz P M - - 1994
During the autumn of 1991, numerous seabird fatalities in Monterey Bay, California, led to the discovery of a new domoic acid-producing diatom, Pseudonitzschia australis. Since this initial event, sizable populations of P. australis, as well as other likely toxin producers, P. pungens f. multiseries and P. pseudodelicatissima, have occurred biannually ...
Coe F L - - 1994
Kidney cells produce at least three proteins that slow the rate of calcium oxalate crystallization. Nephrocalcin (NC), one of the three, is an acidic glycoprotein that contains gamma-carboxyglutamic acid (GLA), and inhibits nucleation, aggregation and growth of calcium oxalate crystals. Nephrocalcin is abnormal in urine of stone-forming patients, in lacking ...
Halabe A - - 1994
Uric acid is the end-product of purine nucleotide metabolism in man. The renal handling of urate is a complicated process, resulting in a fractional clearance of 8.2-10.3%. The anhydrous form is thermodynamically the most stable uric acid crystal. Uric acid is a weak acid that ionizes with a Pka at ...
Poonkuzhali B - - 1994
Effect of uric acid on sodium oxalate-induced biochemical and histological changes were studied in rats. Rats injected with sodium oxalate (0.7 mg/100 g body wt, ip) show calcium deposits in the lumen of kidney tubules. Uric acid administration was found to potentiate calcium oxalate calculi formation. Lipid peroxide formation was ...
Pinheiro-Carrera M - - 1994
Rats with severe unilateral dopamine denervation (> or = 95% dopamine deficit), produced by intracerebral injection of 6-hydroxydopamine (6-OHDA) into the ventral tegmentum nigrostriatal dopamine neurons, were administered 25 mg/kg L-dopa (3,4-dihydroxyphenylalanine) methyl ester/2 mg/kg carbidopa. The neurochemical effects of the L-dopa treatment on uric acid in the cortex and ...
Zhang J - - 1994
Simultaneous indoor and outdoor measurements of organic acids were made at six residential houses located in a suburban New Jersey area during the summer of 1992. Each house was measured for six days and controlled for ventilation and gas combustion conditions. The study presents the first set of simultaneous measurements ...
Liu A - - 1994
A glassy carbon electrode was pretreated electrochemically and was coated with a copolymer of maleic acid anhydride attached with Eastman-AQ55D (MA/AQ). The voltammetric behavior of a series of biologically important compounds, such as dopamine, L-DOPA, DOPAC, ascorbic acid and uric acid were examined at both pretreated and coated electrodes. Electrochemical ...
Desole M S - - 1994
In 6-month-old male Wistar rats, levels of dopamine (DA), dihydroxyphenylacetic acid (DOPAC), ascorbic acid (AA), dehydroascorbic acid (DHAA), uric acid and glutathione (GSH) were determined by HPLC in the striatum and striatal synaptosomes after subchronic oral exposure to MnCl2 50-100-150 mg/kg. Mn significantly decreased levels of DA and GSH and ...
Nawa S - - 1994
An experimental model of acute respiratory failure (ARF) was successfully developed in dogs by endotracheal sea water infusion. Serial changes in blood gases and hemodynamics, and histological changes in the lungs after use of this method were compared with those of the conventional model induced by oleic acid, and the ...
Borghi L - - 1993
We investigated the prevalence of stone disease and urinary stone risk factors in machinists chronically exposed to a hot environment and massive sweating, without interference of nephrotoxic metals or other lithogenic compounds. The study was performed at a glass plant and exposure to heat stress was estimated by the Wet ...
Newnham D M - - 1993
1 The purpose of the study was to assess the bronchorelaxant effects of the beta3-adrenoceptor agonist BRL 35135 in normal human airways. 2 Eight healthy male subjects were studied, having previously demonstrated airways responsiveness to inhaled salbutamol 200 microg, with a group mean (+/- s.e. mean) fall in airways resistance ...
Enkvetchakul B - - 1993
Tissue infiltration by white blood cells in poultry with ascites has been reported, which could alter endogenous antioxidant status from oxidant stress. Therefore, the objective of this study was to determine the effect of ascites on ascorbic acid, tocopherol, and glutathione (GSH), which are major intracellular antioxidants. Broiler chicks (1 ...
Cao G - - 1993
It is often assumed that the oxygen radical defense could be further improved by higher concentration of antioxidants. But this has not been demonstrated over a wide range of concentrations. There are different types of oxygen radicals produced in the body and the antioxidant protection against them may not positively ...
Descombes E - - 1993
In order to elucidate some conflicting data reported in the literature the diffusion kinetics between red blood cells (RBC) and plasma during dialysis were studied for urea, creatinine and uric acid. Several complementary studies were performed. According to our results urea diffuses very rapidly from RBC to plasma and is ...
Hayabuchi Y - - 1993
This study examines the exacerbating factors of hyperuricaemia in patients with cyanotic congenital heart disease (CCHD). We studied 59 CCHD patients aged 1 month-30 years. The following variables were assessed: serum uric acid levels, red blood cell count, haemoglobin, hematocrit, partial oxygen pressure and arterial oxygen saturation. Uric acid excretion ...
Desole M S - - 1993
In 6-month-old male Wistar rats, levels of dopamine (DA), dihydroxyphenylacetic acid (DOPAC), ascorbic acid (AA), dehydroascorbic acid (DHAA), uric acid, glutathione (GSH) and 1-methyl-4-phenylpyridinium ion (MPP+) were determined by HPLC in the crude striatal synaptosomal fraction after single injections of MPTP 35 mg/kg i.p. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induced a 32.5% death ...
Ogawa Y - - 1993
The circadian rhythm of the urinary saturation of uric acid, sodium acid urate, and ammonium acid urate was studied in 5 normal healthy male volunteers before and during 5 days of treatment with sodium-potassium citrate (1 g t.i.d., 1 g q.i.d., or 3 g t.i.d.). Urinary saturation was estimated on ...
Wu T T - - 1993
Fragmentation has become the standard therapy for urinary calculi in the modern era. Stone fragility as well as position and size are important for the determination of a treatment program. To compare the efficacy of stone fragmentation, seven kinds of human urinary calculi with known composition (calcium oxalate monohydrate and ...
Manowitz P - - 1993
The effect of gambling and gaming on plasma levels of uric acid was studied. Blood samples were obtained from normal subjects while they gambled for money or while they played checkers without betting. There was an interaction of time and activity reflecting primarily an association of increased uric acid levels ...
Berny C - - 1993
The biochemical changes in blood during intraperitoneal chemohyperthermia (IPCH) were examined by carrying out complete assessments before and after the operation. These assessments were made up of 23 parameters: Na, K, Cl, CO2, urea, creatinine, proteins, glucose, calcium, phosphates, magnesium, bilirubin, uric acid, lactic acid, CRP, ASAT, ALAT, CK, LDH, ...
Tan S - - 1993
Xanthine oxidase, a key source of reactive oxygen species, and purine substrates are detected in the circulation after ischemia-reperfusion. High levels of uric acid, produced by a xanthine oxidase-catalyzed reaction, are found in human plasma. We studied whether uric acid could alter xanthine oxidase activity in plasma obtained from eight ...
Modgil R - - 1993
Influence of six (10, 20, 30, 40, 50, and 60%) levels of bruchids infestation on the contents of selected antinutritional factors-phytic acid, saponins, trypsin inhibitors activity (TIA) of three (chickpea, red gram, and green gram) pulses was studied. Comparisons of infested samples were made with uninfested controls of each pulse. ...
Peden D B - - 1993
Uric acid, an important scavenger of ozone, has been identified as the major low molecular weight antioxidant in baseline and cholinergically induced nasal secretions. The purpose of this study was to determine the specific tissue source of uric acid in airway secretions. The secretion of uric acid is increased by ...
Reaich D - - 1993
The effect of correction of acidosis in chronic renal failure (CRF) was determined from the kinetics of infused L-[1-13C]leucine. Nine CRF patients were studied before (acid) and after two 4-wk treatment periods of sodium bicarbonate (NaHCO3) and sodium chloride (NaCl) (pH: acid 7.31 +/- 0.01, NaHCO3 7.38 +/- 0.01, NaCl ...
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