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Fichna Marta M Department of Endocrinology and Metabolism, Poznan University of Medical Sciences , Poznan , Poland - - 2014
Abstract Autoimmune Addison's disease (AAD) results from T cell-mediated destruction of the adrenal cortex, commonly accompanied by autoantibodies to 21-hydroxylase (21OH). In order to gain insight into the obscure aetiology of this disease, we investigated the roles of the IL2 and IL2RA genes, encoding interleukin-2 and subunit alpha of its ...
Subash-Babu Pandurangan P Molecular Biology Research Lab, Department of Food and Nutrition, College of Food and Agricultural Sciences, King Saud University, Riyadh, 11451, Kingdom of Saudi Arabia. - - 2014
We aimed to explore the antiadipogenic and adipolysis effect of hesperetin in human mesenchymal stem cells (hMSCs)-induced adipogenesis. IC50 value of hesperetin was higher for hMSCs such as 149.2 ± 13.2 μmol for 24 h and 89.4 ± 11.4 μmol in 48 h, whereas in preadipocytes was 87.6 ± 9.5 ...
Shamsabadi Reza Mahvelati RM Department of Orthodontics, School of Dentistry, Hamedan University of Medical Sciences, Hamedan, - - 2014
Oral pemphigus vulgaris (PV) is a rare blistering disorder of the skin and mucous membranes in the mouth. Inflammasome serves as a molecular platform that mediates the autoactivation of caspase-1, which cleaves the pro-forms of IL-1β and IL-18 to active forms. Therefore, the main aim of this study was to ...
Hong Fanzhen F Department of Obstetrics and Gynaecology, The Second Hospital of Shandong University, Jinan, China - - 2014
To detect microRNA (miR)-126 expression and its correlation with vascular endothelial growth factor (VEGF) levels in placentas from patients with pre-eclampsia compared with those from normotensive pregnancies. miR-126 expression, and VEGF mRNA and protein levels, in placentas collected sequentially from patients with pre-eclampsia and normotensive pregnancies were measured using real-time ...
Xie Shuan-Shuan SS Department of Respiratory Medicine, Shanghai Tenth People's Hospital, Tongji University, Shanghai, - - 2014
To investigate the relationship between expression of matrix metalloproteinase (MMP)-9 and expression of adenylyl cyclase-associated protein (CAP)-1 in chronic obstructive pulmonary disease (COPD). Patients with possible respiratory disease were recruited into the study and divided into a COPD group and a non-COPD group on diagnosis. Pulmonary function tests were performed ...
Suarez Edna E Plastic and Reconstructive Surgery Research, Manchester Institute of Biotechnology (MIB), University of Manchester, 131 Princess Road, Manchester, M1 7ND, - - 2014
Among raised dermal scar types, keloid (KS) and hypertrophic scars (HS) are considered to present clinical similarities, but there are no known specific biomarkers that allow both scar types to be easily distinguished. Development and progression of raised dermal scars comprises the activation of several molecular pathways and cell defence ...
Schneider Hannah A HA Department of Pediatric Pathology, University Clinic Bonn, Sigmund-Freud-Strasse 25, 53127, Bonn, - - 2014
There is evidence of a probable key role of the activator protein-2 γ (AP-2γ) in placental development. It is still an open question whether AP-2γ expression may be influenced by preeclampsia, which is a serious pregnancy complication, or by smoking, which has deleterious effects on trophoblastic development. Thus, the expression ...
Ma Danxu D Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences , Beijing , China - - 2014
Objectives: S100 calcium binding protein A12 (S100A12) has been supposed to be a pro-inflammatory factor associated with non-infectious inflammatory diseases. However, whether S100A12 is involved in the inflammatory process of primary biliary cirrhosis (PBC) has not been shown. Methods: The levels of S100A12 mRNA transcripts in peripheral mononuclear blood cells ...
McAinch A J AJ Centre for Chronic Disease Prevention and Management, College of Health and Biomedicine, Victoria University, P.O. Box 14428, Melbourne, VIC, 8001, Australia, - - 2014
To investigate the mechanisms of impairments in oxidative metabolism in obese and diabetic (T2DM) skeletal muscle, this study analysed the adaptive expression of genes involved in fatty acid (FA) oxidation and mitochondrial biogenesis in primary myotubes treated with elevated FAs. Muscle samples from obese or obese T2DM donors were stored ...
Rateb Amr A AA Department of Dermatology, Kasr AlAini Hospital, Cairo University, Cairo, - - 2014
Purpose of the Study: To study the expression of osteopontin (OPN) in alopecia areata (AA) lesions in a trial to clarify its possible role in the pathogenesis of such a disease. Procedures: Tissue level of OPN was measured in 28 AA patients as well as 25 age- and sex-matched healthy ...
Selek Alev A Department of Endocrinology and Methabolism, Faculty of Medicine, Kocaeli University, Kocaeli, 41380, Turkey, - - 2014
The purpose of this study was to evaluate aromatase enzyme expression in growth hormone (GH) secreting adenomas and comparison with prolactinomas, nonfunctional adenomas, and normal pituitary tissues. Also the impact of its expression on clinical and prognostic features was evaluated. 38 acromegaly, 26 prolactinoma, and 31 nonfunctional pituitary adenoma and ...
Zhao Yue Y Reproductive Medical Center, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, - - 2014
Context: Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine disorder accompanied by chronic low-grade inflammation, but the molecular mechanism remains unclear. Objective: We investigated the action of WNT5a in the development of chronic inflammation in PCOS, and the related molecular signaling pathways. Design and Setting: This was a prospective study ...
Matthaei Mario M The Wilmer Eye Institute, Johns Hopkins Medical Institutions, Baltimore, USA; Department of Ophthalmology, University of Cologne, Cologne, Germany; Department of Ophthalmology, University Medical Center Hamburg-Eppendorf, Hamburg, - - 2014
Fuchs endothelial corneal dystrophy (FECD) is a genetically heterogeneous disease. Hypothesizing that cellular senescence may be relevant in FECD pathogenesis, genetically undifferentiated late-onset FECD endothelial samples were analyzed to identify common changes of specific senescence-related transcripts. Total RNA was extracted from 21 FECD endothelial samples retrieved from patients undergoing lamellar ...
Bragde Hanna - - 2014
Blood-based diagnostics has the potential to simplify the process of diagnosing celiac disease (CD). Although high levels of autoantibodies against tissue transglutaminase (anti-TG2) are strongly indicative of active CD, several other scenarios involve a need for additional blood-based CD markers. We investigated the levels of messenger RNA (mRNA) in whole ...
Jonasova Anna A 1st Medical Clinic, General University Hospital - - 2014
Down-regulation of cereblon (CRBN) gene expression is associated with resistance to the immunomodulatory drug lenalidomide and poor survival outcomes in multiple myeloma patients. However, the importance of CRBN gene expression in patients with myelodysplastic syndrome (MDS) and its impact on lenalidomide therapy are not clear. In this study, we evaluate ...
Chen Zhong-Hua ZH Department of Anesthesiology, Shaoxing People's Hospital and Shaoxing Hospital of Zhejiang University, Shaoxing, 312000, - - 2014
The NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflammasome plays an important role in a variety of diseases. However, the role of NLRP3 in the human intervertebral disc (IVD) degeneration remains unknown. In the present study, we assessed the expression levels of the NLRP3 inflammasome and its downstream targets ...
Mitani Akio A Department of Periodontology, School of Dentistry, Aichi Gakuin University, Nagoya, - - 2014
Background: Interleukin (IL)-35 plays an important role in immune regulation through the suppression of effector T cell populations, including T helper 17 (Th17) cells. Although Th17 cells and IL-17 are involved in the pathogenesis of periodontitis, the level of IL-35 in inflamed periodontal tissues is unclear. Here, we investigated IL-35, ...
Locatelli Jamille J Center for Research in Biological Sciences, Federal University of Ouro Preto, Ouro Preto, Brazil; Sports Center, Federal University of Ouro Preto, Brazil. Electronic address: - - 2014
To identify the effects of swimming training on the mRNA expression and protein levels of the calcium handling proteins in the hearts of renovascular hypertensive rats submitted to swimming protocol during 6weeks. Fischer rats with renovascular hypertension 2-kidney 1-clip (2K1C) and SHAM groups were divided among sedentary and exercised groups. ...
Huang H H Department of Orthopedics, the Linyi People's Hospital, Linyi, Shangdong, China. - - 2014
Relaxin-2 (RLN2) and calcium-binding protein S100A4 was overexpressed in many cancers. Experimental evidence indicated enhanced tumor cell invasion by RLN2 involves the upregulation of S100A4. However, the relationship between them in cancers is not clear. In the present study, we investigate the expression of relaxin-2 protein and calcium-binding protein S100A4 ...
Köseoğlu S S Department of Periodontology, Faculty of Dentistry, İzmir Katip Çelebi University, İzmir, - - 2014
Interleukin-33 (IL-33) controls T-helper type 2 (Th2) cytokines and the development of mast cells. This study aimed to investigate the expression of IL-33 and its association with RANKL and osteoprotegerin (OPG) in periodontal health and experimental periodontitis. Eighteen Wistar rats were assigned to two study groups of nine animals each: ...
Zhao Mingfei M Department of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310009, - - 2014
So far, several studies on the association between osteopontin (OPN) expression and glioma have been performed, but the conclusion still was not clear. The aim of the present meta-analysis was to determine the relationship between OPN expression and prognosis of patients with glioma. The electronic database was searched for articles ...
Lin Danping D Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, Jiangsu, - - 2014
Interleukin-17 (IL-17 or IL-17A), a pleiotropic cytokine produced by T helper (Th) 17 cells, is involved in the pathogenesis of various autoimmune and inflammatory disorders, including periodontitis. Although the ability of pro-inflammation in periodontitis have been widely investigated, the other biological functions of IL-17, including its role in bone remodeling ...
Mansoor Adnan A Department of Pathology & Laboratory Medicine, Division of Hematology and Transfusion Medicine, University of Calgary/Calgary Laboratory Services (CLS), Calgary, AB, - - 2014
Among plasma cell myeloma (PCM) patients, gene expression profiling (GEP)-based molecular classification has proven to be an independent predictor of survival, after autologous stem cell transplantation. However, GEP has limited routine clinical applicability given its complex methodology, high cost, and limited availability in clinical laboratories. In this study, we have ...
Qin Yang - - 2014
It is well-documented that both chemokine (C-C motif) ligand 19 (CCL19) and 21 (CCL21) mediate cell migration and angiogenesis in many diseases. However, these ligands' precise pathological role in ankylosing spondylitis (AS) has not been elucidated. The objective of this study was to examine the expression of CCL19 and CCL21 ...
Nakamura Shinsuke S Molecular Pharmacology, Department of Biofunctional Evaluation, Gifu Pharmaceutical University, 1-25-4 Daigaku-nishi, Gifu, 501-1196, - - 2014
Purpose:The incidence of blindness is increasing, in part, because of the abnormal ocular neovascularization. Anti-VEGF therapies have yielded impressive results; however, they are not a cure for blindness. Recently, metallothioneins (MTs) 1 and 2 have been implicated in the process of angiogenesis. Therefore, we investigated whether MT 1 and MT ...
Zhao Ruibo R Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, 410008, China, - - 2014
The objective of this study is to explore the effect of mmu-miR-142-5p on osteoblast and the mechanism. Neonatal New Zealand rabbits were selected to collect and culture primary osteoblasts after being killed. The agonists agomiR-142-5p, agomiR-NC and inhibitors antagomiR-142-5p, antagomiR-NC were transfected to establish mmu-miR-142-5p osteoblast model. 48 h after transfection, ...
Harada-Shirado Kayo K Department of Cardiology and Hematology, Fukushima Medical University, Fukushima, - - 2014
Overexpression of high mobility group AT-hook 2 (Hmga2), which is negatively regulated by MIRLET7 micro RNAs through 3'-untranslated region (3'UTR), causes proliferative haematopoiesis mimicking myeloproliferative neoplasms (MPNs) and contributes to progression of myelofibrosis in mice. Thus, we investigated HMGA2 mRNA expression in 66 patients with MPNs including 23 polycythaemia vera ...
Hao Y Y State Key Laboratory of Animal Nutrition, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, - - 2014
This study was conducted to determine the effects of heat shock protein 90 (HSP90) expression on pH, lipid peroxidation, heat shock protein 70 (HSP70), and glucocorticoid receptor (GR) expression of pectoralis major in broilers exposed to acute heat stress. In total, 90 male broilers were randomly allocated to 3 groups: ...
Kandratavicius Ludmyla L Department of Neurosciences and Behavior, Ribeirao Preto School of Medicine, University of Sao Paulo (USP), Ribeirao Preto, Brazil; Center for Interdisciplinary Research on Applied Neurosciences (NAPNA), University of Sao Paulo (USP), Ribeirao Preto, - - 2014
Biologic substrates behind the close association between mesial temporal lobe epilepsy (MTLE) and psychiatric comorbidities are largely unknown. Heat shock protein 70 (HSP70) and HSP90 are ubiquitous molecular chaperones that play important roles in functions from cellular stress response to receptor trafficking control. There are controversial findings regarding HSP expression ...
Sanchez-Castro Marta M INSERM, UMR1087, l'institut du thorax, Nantes, France; Université de Nantes, Nantes, - - 2014
Congenital heart disease (CHD) is the leading malformation among newborns. However, its genetic basis remains mostly unknown. We report a child with transposition of the great arteries, ventricular septal defect and coarctation of the aorta. By array comparative genomic hybridization, we identified a duplication of the 5' half of semaphorin3D ...
Jia Hong-Ling - - 2014
Changes of miRNAs in exosome have been reported in different disease diagnosis and provided as potential biomarkers. In this study, we compared microRNA profile in exosomes in 5 MHFMD and 5 ESHFMD as well as in 5 healthy children. Different expression of miRNAs in exosomes across all the three groups ...
Isoda Atsushi A Department of Hematology, National Hospital Organization Nishigunma Hospital, Gunma, - - 2014
L-type amino-acid transporter 1 (LAT1) plays a key role in cell growth and survival. To determine the prognostic significance of LAT1 in multiple myeloma (MM), we investigated the expression of LAT1 and its functional subunit, 4Fc heavy chain (CD98), on myeloma cells by immunohistochemistry in 100 newly diagnosed MM patients. ...
Zhao Zhaohui Z Department of Neurosurgery and Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, P.R. - - 2014
The aberrant constitutive activation of nuclear factor-κB (NF-κB) has been observed in glioblastomas, while NF-κB inhibitor alpha (NFKBIA) inhibits the NF-κB signaling pathway under several physiological processes. However, the contribution of NFKBIA to glioblastomas is poorly understood. In the present study, using gene sequencing, we identified rs1957106 as a novel single nucleotide ...
Hamedi Mojgan M Centre Clinical and Diagnostic Oral Sciences, Institute of dentistry, Bart's and The London School of Medicine and Dentistry, London, United - - 2014
Behçet's disease (BD) is a chronic, multi systemic, recurrent vasculitis disease of unknown aetiology. Pro-inflammatory cytokines are a key feature of the disease but the triggers for their induction are not well understood and/or controversial. Suppressor of Cytokine Signalling (SOCS) proteins which negatively regulate the JAK-STAT signalling pathway of cytokine ...
Kong Lingxue L Department of Periodontics and Oral Mucosa, Jinan Stomatologic Hospital, No. 101 Jingliu Road, Jinan, Shandong, China; State Key Laboratory of Oral Diseases, West China College of Stomatology, Sichuan University, Chengdu, Sichuan, - - 2014
Theaflavins, the main polyphenols in black tea, possesses a wide range of beneficial pharmacological properties. Porphyromonas gingivalis (P. gingivalis) is a major aetiological agent associated with periodontitis, a chronic inflammatory disease affecting tooth-supporting tissues. The aim of the present study is to investigate the effect of theaflavins on pathogenic properties ...
Sheridan Rachel R Division of Pathology, Department of Pediatrics, University of Cincinnati Medical College, Cincinnati, Ohio, - - 2014
Oxidative stress and increased apoptosis are implicated in the pathogenesis of many disorders of pregnancy, including preeclampsia (PE) and fetal growth restriction (FGR). Since the transcription factor FOXO1 (forkhead box protein O1) is implicated in the regulation of a variety of cellular processes, including resistance to oxidative stress, apoptosis and ...
Yuan Yuan Y Children's Hospital of Fudan University, Shanghai, - - 2014
Background: Tetralogy of Fallot (ToF) is the most common form of cyanotic congenital heart disease and is a major cause of significant morbidity and mortality. VANGL2 is a critical gene in the planar cell polarity pathway that plays an important role in the development of the heart. This study investigates ...
Zhang Guoyu G Department of Infectious Diseases, First Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi' an, 710061, Shaanxi, - - 2014
Programmed cell death-1 (PD-1) is involved in hepatitis B virus (HBV) infection and single-nucleotide polymorphism (SNP) rs10204525 in the 3'-untranslated region (3' UTR) of PD1 gene was shown to be associated with the disease course of HBV infection. This study examined the associations of PD-1 mRNA expression with the clinical ...
Lee Jivianne T JT Orange County Sinus Institute, Southern California Permanente Medical Group (SCPMG), Irvine, CA; Department of Otolaryngology-Head and Neck Surgery, David Geffen School of Medicine at University of California Los Angeles (UCLA), Los Angeles, - - 2014
Airway secretions contain endogenous antimicrobial factors (AMFs) that contribute to the innate host defense of the respiratory tract. Antibacterial peptides as well as host-derived lipids including cholesteryl esters have been detected in maxillary lavage fluid. Sterol O-acyltransferase 1 (SOAT1) is a key enzyme in cholesteryl ester production. The purpose of ...
Ginath Shimon S Department of Obstetrics and Gynecology, Edith Wolfson Medical Center, Holon and Sackler Faculty of Medicine, Tel-Aviv, - - 2014
Abstract Objective: Heparanase plays a central role in processes of placentation. Abnormal placentation may result in inadequate uteroplacental blood flow leading to unsuccessful pregnancy outcome and preeclampsia. We aimed to evaluate heparanase expression in placentas of preeclamptic patients. Materials & Methods: Placental tissue samples were collected immediately after delivery from ...
Wang Jun J Department of Orthopedics , the Second Xiangya Hospital, Central South University, Changsha, Hunan Province , - - 2014
Background and purpose - Non-traumatic osteonecrosis is a progressive disease with multiple etiologies. It affects younger individuals more and more, often leading to total hip arthroplasty. We investigated whether there is a correlation between inducible nitric oxide synthase (iNOS) expression and osteocyte apoptosis in non-traumatic osteonecrosis. Patients and methods - ...
Smith Nicola L D NL Manchester Fungal Infection Group, Faculty of Medical and Human Science, The University of Manchester, UK Faculty of Medical and Human Science, The University of Manchester; Manchester Academic Health Science Centre; University Hospital South Manchester NHS Foundation Trust; NIHR South Manchester Respiratory and Allergy Clinical Research Facility, Manchester, - - 2014
 Aspergillus fumigatus causes chronic cavitary pulmonary aspergillosis (CCPA) and allergic bronchopulmonary aspergillosis (ABPA), in overtly immunocompetent and atopic individuals respectively. Disease mechanisms are poorly understood but may be related to increased neutrophil presence and activation. Pro-platelet basic protein (PPBP) is a potent neutrophil chemoattractant and activator whose expression is repressed ...
Sziksz Erna E MTA-SE, Pediatrics and Nephrology Research Group, Budapest, - - 2014
Celiac disease (CD) is a chronic autoimmune enteropathy caused by exposure to dietary gluten in genetically predisposed individuals. The transcription factor peroxisome proliferator-activated receptor gamma (PPARγ) was shown to exert protective effects in several immune-mediated disorders. Activation of PPARγ suppressed the expression of thymic stromal lymphopoietin (TSLP), an inducer of ...
Viart Victoria V INSERM U827, Laboratoire de Génétique de Maladies Rares, Montpellier, France Université Montpellier I, UFR de Médecine, Montpellier, France Laboratoire de Génétique Moléculaire, CHU Montpellier, Montpellier, - - 2014
The CFTR gene displays a tightly regulated tissue-specific and temporal expression. Mutations in this gene cause cystic fibrosis (CF). In this study we wanted to identify trans-regulatory elements responsible for CFTR differential expression in fetal and adult lung, and to determine the importance of inhibitory motifs in the CFTR-3'UTR with ...
Zhao Junmei J Henan Key Lab of Experimental Haematology, Henan Institute of Haematology, Henan Tumor Hospital affiliated to Zhengzhou University, Zhengzhou 450008, - - 2014
Our previous studies have demonstrated that arsenic trioxide (ATO) had the clinical efficacy in treating patients with aplastic anemia (AA). However, the mechanisms remain to be elucidated. The important components of the bone marrow hematopoietic microenvironment, bone marrow mesenchymal stem cells (BMSCs), are often altered in AA patients. In this ...
Surowiak Pawel P Department of Histology and Embryology, Wroclaw Medical University, Wrocław, Poland; Polish Association of Aesthetic and Anti-Aging Medicine, PTL, Warsaw, Poland; DermaMed Institute of Aesthetic Medicine, Wrocław, - - 2014
Interleukins and NFκ-B are involved in the development of inflammatory reactions. It has been suggested that these proteins are important contributing factors in the process of photoaging of skin. Moreover, interleukins and NFκ-B are known to be capable of inducing expression of cyclooxygenase 2 (COX-2). Expression of COX-2 in various ...
Lin Xue-cai - - 2014
Emerging evidence indicates that the interaction between glucocorticoid receptor α (GRα) and nuclear factor κB (NF-κB) is a key pathogenetic cross talk in the autoimmune and inflammatory disorders. The objective of this study was to determine the GRα expression in patients with oral lichen planus (OLP) and investigate its correlation ...
Inada Noriko N Division of Ophthalmology, Department of Visual Sciences, Nihon University School of Medicine, 30-1 Oyaguchi-Kamichou, Itabashi-ku, Tokyo, 173-8610, Japan, - - 2014
CCL20, the single chemokine ligand for CCR6, contributes to recruiting CCR6-expressing memory B cells, memory T cells, Th17 cells and dendritic cells, and is involved in regulating immune responses, homeostasis, and inflammation in mucosal tissues. CCL20 messenger RNA (mRNA) expression was analyzed in the conjunctival epithelium in an in vivo ...
Barman-Aksözen Jasmin J Institute of Laboratory Medicine, Triemli Hospital, Zürich, - - 2014
The activity of the erythroid-specific isoenzyme of 5-aminolevulinic acid synthase (ALAS2), the first and rate-limiting enzyme in heme biosynthesis, is down-regulated during iron-deficiency. Ferrochelatase (FECH), the last enzyme of this pathway, inserts iron into protoporphyrin IX (PPIX) to form heme. Patients with erythropoietic protoporphyria (EPP), an inherited deficiency in FECH, ...
Keller Simona S Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università degli Studi di Napoli Federico II, via S. Pansini, 5, 80131 Naples, Italy; Istituto di Endocrinologia ed Oncologia Sperimentale IEOS-CNR, Naples, Italy. Electronic address: - - 2014
In this study we assessed the BDNF promoter IV methylation state of a large genomic region surrounding promoter IV and evaluated BDNF transcript IV expression from prefrontal cortex and striatum of 15 schizophrenic and 15 control subjects. In prefrontal cortex, a single CpG site at -93, appeared to be undermethylated ...
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