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Su Fangju F Department of Cardiology, Lanzhou General Hospital, People's Liberation Army, Lanzhou, Gansu 730050, P.R. - - 2014
Atrial interstitial fibrosis plays a dual role in inducing and maintaining atrial fibrillation (AF). Hypoxia-inducible factor-1α (HIF-1α) has been reported as closely associated with renal, liver and pulmonary fibrosis diseases. However, whether HIF-1α is involved in myocardial fibrosis, and the associations between HIF-1α, transforming growth factor-β1 (TGF-β1) and matrix metalloproteinase-9 ...
Orvieto Raoul - - 2014
BackgroundOvarian hyperstimulation syndrome (OHSS), is characterized by marked ovarian enlargement and acute third space fluid sequestration that almost always develops after hCG administration or in early pregnancy. OHSS is similar to vascular leak syndrome (VLS), which may be attributable to the massive increase in systemic inflammatory cytokines. In the present ...
Fukusato Toshio T Department of Pathology, Teikyo University School of Medicine, Tokyo, - - 2014
Recent studies have indicated that hepatocellular adenoma (HCA) is a heterogenous group of benign tumors with various genetic and clinicopathological characteristics. We delineated the clinicopathological characteristics of HCA subtypes and evaluated the expression of transporter protein OATP1B3 in HCAs. HCAs in 34 Japanese patients were investigated immunohistochemically and classified into ...
Xu Jie J Bachelor Degree, Department of Stomatology, Hubei University of Science and - - 2014
Background: The accumulation of advanced glycation end products (AGEs) appears to be the main factors responsible for modulating periodontal inflammation in diabetes. The aim of the study is to examine the effects of AGEs on human periodontal ligament cells inflammation and to investigate the mechanism with a specific emphasis on ...
Li Jian - - 2014
Gefitinib, an EGFR-tyrosine kinase inhibitor, significantly improve prognosis in patients with advanced non-small cell lung cancer (NSCLC). The aim of this study was to evaluate the usefulness of MUC1 and vascular endothelial growth factor (VEGF) mRNA expression in peripheral blood as means of predicting benefit from gefitinib therapy in NSCLC ...
Zou Yaguang Y Department of Stomatology, NanFang Hospital, Southern Medical University, Guangzhou, 510515, - - 2014
Periodontitis, a common chronic inflammatory disease of the periodontium, is caused by dental plaque formation induced by microorganisms. Recent studies have demonstrated that lncRNAs play a critical role in the regulation of gene expression and in the pathogenesis of diseases. To demonstrate that periodontitis is associated with lncRNAs, microarray analysis ...
Mohammed-Geba Khaled K Departamento de Biología Marina y Acuicultura, Instituto de Ciencias Marinas de Andalucía, Consejo Superior Investigaciones Científicas (CSIC), 11510, Puerto Real, Cádiz, Spain, - - 2014
To assess the role of the GH/IGF-I axis in osmotic acclimation of the gilthead seabream Sparus aurata, juvenile specimens were acclimated to four environmental salinities: hyposmotic (5 ‰), isosmotic (12 ‰) and hyperosmotic (40 and 55 ‰). The full-length cDNAs for both pituitary adenylate cyclase-activating peptide (PACAP) and prepro-somatostatin-I (PSS-I), the precursor for ...
Crago Jordan J School of Freshwater Sciences, University of Wisconsin-Milwaukee, Milwaukee, WI, 53204, USA, - - 2014
In this study, male fathead minnows (FHM) (Pimephales promelas) and juvenile rainbow trout (RT; Oncorhynchus mykiss) were exposed to two different surfactant mixtures of analytical-grade nonlyphenol, 4-tert octyphenol, octylphenol ethoxylates, nonylphenol ethoxylates, and the herbicide 2,4-dichlorophenoxyacetic acid (2,4-D). After a 7-days exposure to environmentally relevant concentrations of these compounds, there ...
He Deng D Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. - - 2014
The present study aimed to identify the characteristics and cross‑talk between transforming growth factor β1 (TGF‑β1) and calcium ions in nephrolithiasis patients with idiopathic hypercalciuria (IH) in order to elucidate the potential mechanisms underlying changes in cell phenotype induced by bone‑associated factors and their influence on renal nephrolithiasis formation. Blood samples ...
Shen Xiao-Ming XM Department of Oncology, Suzhou Xiangcheng People's Hospital, Suzhou, 215131, Jiangsu Province, - - 2014
The aim was to determine changes in dihydropyrimidine dehydrogenase (DPD) and thymidylate synthase (TS) mRNAs in the blood of advanced gastric cancer (AGC) patients to see whether these enzymes affected the patients' response to S-1-based chemotherapy and prognosis. For this purpose, pretreatment DPD/TS mRNA expressions were determined in 40 AGC ...
Jevalikar Ganesh S - - 2014
Abstract Objective: We analyzed mRNA expression of X-linked inhibitor of apoptosis protein (XIAP) in patients with Turner syndrome (TS) and examined its association with phenotypic features. Subjects and methods: XIAP mRNA expression levels were investigated in 98 patients with TS in total RNA extracted from blood leucocytes by real time ...
Hsu Chin-Mu CM Terry Fox Cancer Research Laboratory, China Medical University Hospital, Taichung, Taiwan, - - 2014
Background/Aim: The altered cellular repair capacity plays a critical role in genomic instability and carcinogenesis. We aimed at evaluating the contribution of the polymorphic variant in apurinic/apyriminidinic endonuclease (APEX1) gene to its mRNA and protein levels and the risk of endometriosis. Patients and Methods: In the current case-control study, 153 ...
Luo Zhenhua Z Department of Periodontics, School of Stomatology, Capital Medical University, Beijing, - - 2014
The objective of this study was to investigate the expression level, clinical significance, and possible regulating role of IL-17F in patients of chronic periodontitis. Periodontal local tissues were obtained from chronic periodontitis (CP) and healthy controls (HC) for real-time PCR (RT-PCR) detection with IL-17F and IL-17A messenger RNA (mRNA). Primary ...
Iwamoto Naoki N Division of Rheumatology, Center of Experimental Rheumatology, University Hospital and Zurich Center of Integrative Human Physiology (ZIHP), Zurich, Switzerland Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, - - 2014
To investigate the role of microRNA-193b-3p (miR-193b) in the vascular pathophysiology of systemic sclerosis (SSc). Expression of miR-193b in skin biopsies and fibroblasts from patients with SSc and normal healthy (NH) controls were determined by real-time PCR. Transfection with miR-193b precursor and inhibitor were used to confirm targets of miR-193b. ...
Romero-Martínez A A University of Valencia, - - 2014
It has been hypothesized that anger expression may be associated with increased salivary immunoglobulin A (sIgA) levels, which is associated with decreased somatic symptoms, and therefore anger expression may be associated with reduced somatic symptoms in intimate partner violence (IPV) perpetrators. This study tested the potential mediating effect of sIgA ...
Zhao An A Department of Urology, University Hospital of Saint-Etienne, Jean Monnet University, France; Zhejiang Cancer Research Institute, Zhejiang Province Cancer Hospital, Hangzhou, - - 2014
There is limited research on cell-free RNA (cf-RNA) in the urine of cancer patients. The present study was performed to detect the cf-RNA in the urine of clear cell renal cell carcinoma (ccRCC). 95 urine samples from ccRCC patients and 50 urine samples from control subjects were analyzed. The cf-RNA ...
Kumar Ashutosh A Institute of Life Sciences, School of Science and Technology, Ahmedabad University, University Road, Navrangpura, Ahmedabad 380009, Gujarat, India Department of Biotechnology, Integral University, Dasauli, P.O. Bas-ha Kursi Road, Lucknow 226026, - - 2014
Zinc oxide (ZnO) nanoparticles are the mostly used engineered metal oxide nanoparticles in consumer products. This has increased the likelihood of human exposure to this engineered nanoparticle (ENPs) through different routes. At present, the majority of the studies concerning ZnO ENPs toxicity have been conducted using in vitro and in ...
Arai Haruna H Department of Nephrology, Fujita Health University School of Medicine, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi, 470-1192, - - 2014
Renal parenchymal lesions in patients with IgG4-related kidney disease (IgG4-RKD) are characterized by tubulointerstitial nephritis with storiform fibrosis and infiltration by high numbers of IgG4-positive plasma cells. The aim of this study was to evaluate the clinical and pathological effects of corticosteroid therapy in patients with IgG4-RKD. Of six patients ...
Gui Dongmei D Department of Ophthalmology, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, P.R. - - 2014
This study aimed to investigate the impacts of erythropoietin (EPO) on the electroretinogram b‑wave (ERG‑b), and on the mRNA and protein expression levels of hypoxia‑inducible factor‑1α (HIF‑1α), inducible nitric oxide synthase (iNOS), cyclooxygenase‑2 (COX‑2) and caspase‑9 in chronic ocular hypertension rats. Episcleral vein cauterization (EVC) was used to establish the ...
Yan Wei W Beijing Neurosurgical Institute, Capital Medical University, Beijing, PR China. Department of Neurosurgery, First Affiliated Hospital of Nanjing Medical University, Nanjing, PR - - 2014
MicroRNAs (miRNAs) are directly involved in the progression in various cancers. To date, no systematic researches have been performed on the expression pattern of miRNA during progression from low grade gliomas to anaplastic gliomas or secondary glioblastomas and those prognostic miRNAs in anaplastic gliomas and secondary glioblastomas. In the present ...
Zheng Huifeng H Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, - - 2014
Gastrodin, as one of the major components extracted from the Chinese herb Gastrodia elata Bl., has many biologic effects, one of which is anti-apoptosis. Apoptosis is considered to be one of the pathogenetic mechanisms in steroid-induced osteonecrosis of the femoral head (ONFH). Therefore, we performed this study to investigate whether ...
Frodl Thomas T Trinity College - - 2014
Alterations of the glucocorticoid system and of hippocampal volumes have consistently been reported in patients with major depressive disorders (MDD). The aim of the present study was to investigate whether the messenger RNA (mRNA) expression of glucocorticoid inducible genes is associated with changes in the cornu ammonis (CA) and dentate ...
Park Jong Sun - - 2014
Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease of unknown causes. Three proteins (mammalian target of rapamycin, mTOR; zinc finger E-box-binding homeobox 1, ZEB1; Rho-associated, coiled-coil containing protein kinase 1, ROCK1) may be related to pulmonary fibrosis. However, they have not been assessed in human pulmonary fibrosis. We assessed ...
Shen Mo M Department of Laboratory Medicine, The First Affiliated Hospital of Wenzhou Medical University, Zhejiang 325000, P.R. - - 2014
Bladder cancer (BCa) is the most common tumor of the urinary system. Chronic inflammation in the papillary urothelial neoplasm of low malignant potential (PUNLMP)may contribute to carcinogenesis, including that of BCa, via poorly understood mechanisms. In this study, we show that the lymphotoxin β receptor (LTβR) is upregulated in BCa via ...
Fichna Marta M Department of Endocrinology and Metabolism, Poznan University of Medical Sciences , Poznan , Poland - - 2014
Abstract Autoimmune Addison's disease (AAD) results from T cell-mediated destruction of the adrenal cortex, commonly accompanied by autoantibodies to 21-hydroxylase (21OH). In order to gain insight into the obscure aetiology of this disease, we investigated the roles of the IL2 and IL2RA genes, encoding interleukin-2 and subunit alpha of its ...
Subash-Babu Pandurangan P Molecular Biology Research Lab, Department of Food and Nutrition, College of Food and Agricultural Sciences, King Saud University, Riyadh, 11451, Kingdom of Saudi Arabia. - - 2014
We aimed to explore the antiadipogenic and adipolysis effect of hesperetin in human mesenchymal stem cells (hMSCs)-induced adipogenesis. IC50 value of hesperetin was higher for hMSCs such as 149.2 ± 13.2 μmol for 24 h and 89.4 ± 11.4 μmol in 48 h, whereas in preadipocytes was 87.6 ± 9.5 ...
Shamsabadi Reza Mahvelati RM Department of Orthodontics, School of Dentistry, Hamedan University of Medical Sciences, Hamedan, - - 2014
Oral pemphigus vulgaris (PV) is a rare blistering disorder of the skin and mucous membranes in the mouth. Inflammasome serves as a molecular platform that mediates the autoactivation of caspase-1, which cleaves the pro-forms of IL-1β and IL-18 to active forms. Therefore, the main aim of this study was to ...
Hong Fanzhen F Department of Obstetrics and Gynaecology, The Second Hospital of Shandong University, Jinan, China - - 2014
To detect microRNA (miR)-126 expression and its correlation with vascular endothelial growth factor (VEGF) levels in placentas from patients with pre-eclampsia compared with those from normotensive pregnancies. miR-126 expression, and VEGF mRNA and protein levels, in placentas collected sequentially from patients with pre-eclampsia and normotensive pregnancies were measured using real-time ...
Xie Shuan-Shuan SS Department of Respiratory Medicine, Shanghai Tenth People's Hospital, Tongji University, Shanghai, - - 2014
To investigate the relationship between expression of matrix metalloproteinase (MMP)-9 and expression of adenylyl cyclase-associated protein (CAP)-1 in chronic obstructive pulmonary disease (COPD). Patients with possible respiratory disease were recruited into the study and divided into a COPD group and a non-COPD group on diagnosis. Pulmonary function tests were performed ...
Suarez Edna E Plastic and Reconstructive Surgery Research, Manchester Institute of Biotechnology (MIB), University of Manchester, 131 Princess Road, Manchester, M1 7ND, - - 2014
Among raised dermal scar types, keloid (KS) and hypertrophic scars (HS) are considered to present clinical similarities, but there are no known specific biomarkers that allow both scar types to be easily distinguished. Development and progression of raised dermal scars comprises the activation of several molecular pathways and cell defence ...
Schneider Hannah A HA Department of Pediatric Pathology, University Clinic Bonn, Sigmund-Freud-Strasse 25, 53127, Bonn, - - 2014
There is evidence of a probable key role of the activator protein-2 γ (AP-2γ) in placental development. It is still an open question whether AP-2γ expression may be influenced by preeclampsia, which is a serious pregnancy complication, or by smoking, which has deleterious effects on trophoblastic development. Thus, the expression ...
Ma Danxu D Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences , Beijing , China - - 2014
Objectives: S100 calcium binding protein A12 (S100A12) has been supposed to be a pro-inflammatory factor associated with non-infectious inflammatory diseases. However, whether S100A12 is involved in the inflammatory process of primary biliary cirrhosis (PBC) has not been shown. Methods: The levels of S100A12 mRNA transcripts in peripheral mononuclear blood cells ...
McAinch A J AJ Centre for Chronic Disease Prevention and Management, College of Health and Biomedicine, Victoria University, P.O. Box 14428, Melbourne, VIC, 8001, Australia, - - 2014
To investigate the mechanisms of impairments in oxidative metabolism in obese and diabetic (T2DM) skeletal muscle, this study analysed the adaptive expression of genes involved in fatty acid (FA) oxidation and mitochondrial biogenesis in primary myotubes treated with elevated FAs. Muscle samples from obese or obese T2DM donors were stored ...
Rateb Amr A AA Department of Dermatology, Kasr AlAini Hospital, Cairo University, Cairo, - - 2014
Purpose of the Study: To study the expression of osteopontin (OPN) in alopecia areata (AA) lesions in a trial to clarify its possible role in the pathogenesis of such a disease. Procedures: Tissue level of OPN was measured in 28 AA patients as well as 25 age- and sex-matched healthy ...
Selek Alev A Department of Endocrinology and Methabolism, Faculty of Medicine, Kocaeli University, Kocaeli, 41380, Turkey, - - 2014
The purpose of this study was to evaluate aromatase enzyme expression in growth hormone (GH) secreting adenomas and comparison with prolactinomas, nonfunctional adenomas, and normal pituitary tissues. Also the impact of its expression on clinical and prognostic features was evaluated. 38 acromegaly, 26 prolactinoma, and 31 nonfunctional pituitary adenoma and ...
Zhao Yue Y Reproductive Medical Center, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, - - 2014
Context: Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine disorder accompanied by chronic low-grade inflammation, but the molecular mechanism remains unclear. Objective: We investigated the action of WNT5a in the development of chronic inflammation in PCOS, and the related molecular signaling pathways. Design and Setting: This was a prospective study ...
Matthaei Mario M The Wilmer Eye Institute, Johns Hopkins Medical Institutions, Baltimore, USA; Department of Ophthalmology, University of Cologne, Cologne, Germany; Department of Ophthalmology, University Medical Center Hamburg-Eppendorf, Hamburg, - - 2014
Fuchs endothelial corneal dystrophy (FECD) is a genetically heterogeneous disease. Hypothesizing that cellular senescence may be relevant in FECD pathogenesis, genetically undifferentiated late-onset FECD endothelial samples were analyzed to identify common changes of specific senescence-related transcripts. Total RNA was extracted from 21 FECD endothelial samples retrieved from patients undergoing lamellar ...
Bragde Hanna - - 2014
Blood-based diagnostics has the potential to simplify the process of diagnosing celiac disease (CD). Although high levels of autoantibodies against tissue transglutaminase (anti-TG2) are strongly indicative of active CD, several other scenarios involve a need for additional blood-based CD markers. We investigated the levels of messenger RNA (mRNA) in whole ...
Jonasova Anna A 1st Medical Clinic, General University Hospital - - 2014
Down-regulation of cereblon (CRBN) gene expression is associated with resistance to the immunomodulatory drug lenalidomide and poor survival outcomes in multiple myeloma patients. However, the importance of CRBN gene expression in patients with myelodysplastic syndrome (MDS) and its impact on lenalidomide therapy are not clear. In this study, we evaluate ...
Chen Zhong-Hua ZH Department of Anesthesiology, Shaoxing People's Hospital and Shaoxing Hospital of Zhejiang University, Shaoxing, 312000, - - 2014
The NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflammasome plays an important role in a variety of diseases. However, the role of NLRP3 in the human intervertebral disc (IVD) degeneration remains unknown. In the present study, we assessed the expression levels of the NLRP3 inflammasome and its downstream targets ...
Mitani Akio A Department of Periodontology, School of Dentistry, Aichi Gakuin University, Nagoya, - - 2014
Background: Interleukin (IL)-35 plays an important role in immune regulation through the suppression of effector T cell populations, including T helper 17 (Th17) cells. Although Th17 cells and IL-17 are involved in the pathogenesis of periodontitis, the level of IL-35 in inflamed periodontal tissues is unclear. Here, we investigated IL-35, ...
Locatelli Jamille J Center for Research in Biological Sciences, Federal University of Ouro Preto, Ouro Preto, Brazil; Sports Center, Federal University of Ouro Preto, Brazil. Electronic address: - - 2014
To identify the effects of swimming training on the mRNA expression and protein levels of the calcium handling proteins in the hearts of renovascular hypertensive rats submitted to swimming protocol during 6weeks. Fischer rats with renovascular hypertension 2-kidney 1-clip (2K1C) and SHAM groups were divided among sedentary and exercised groups. ...
Huang H H Department of Orthopedics, the Linyi People's Hospital, Linyi, Shangdong, China. - - 2014
Relaxin-2 (RLN2) and calcium-binding protein S100A4 was overexpressed in many cancers. Experimental evidence indicated enhanced tumor cell invasion by RLN2 involves the upregulation of S100A4. However, the relationship between them in cancers is not clear. In the present study, we investigate the expression of relaxin-2 protein and calcium-binding protein S100A4 ...
Köseoğlu S S Department of Periodontology, Faculty of Dentistry, İzmir Katip Çelebi University, İzmir, - - 2014
Interleukin-33 (IL-33) controls T-helper type 2 (Th2) cytokines and the development of mast cells. This study aimed to investigate the expression of IL-33 and its association with RANKL and osteoprotegerin (OPG) in periodontal health and experimental periodontitis. Eighteen Wistar rats were assigned to two study groups of nine animals each: ...
Zhao Mingfei M Department of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310009, - - 2014
So far, several studies on the association between osteopontin (OPN) expression and glioma have been performed, but the conclusion still was not clear. The aim of the present meta-analysis was to determine the relationship between OPN expression and prognosis of patients with glioma. The electronic database was searched for articles ...
Lin Danping D Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, Jiangsu, - - 2014
Interleukin-17 (IL-17 or IL-17A), a pleiotropic cytokine produced by T helper (Th) 17 cells, is involved in the pathogenesis of various autoimmune and inflammatory disorders, including periodontitis. Although the ability of pro-inflammation in periodontitis have been widely investigated, the other biological functions of IL-17, including its role in bone remodeling ...
Mansoor Adnan A Department of Pathology & Laboratory Medicine, Division of Hematology and Transfusion Medicine, University of Calgary/Calgary Laboratory Services (CLS), Calgary, AB, - - 2014
Among plasma cell myeloma (PCM) patients, gene expression profiling (GEP)-based molecular classification has proven to be an independent predictor of survival, after autologous stem cell transplantation. However, GEP has limited routine clinical applicability given its complex methodology, high cost, and limited availability in clinical laboratories. In this study, we have ...
Qin Yang - - 2014
It is well-documented that both chemokine (C-C motif) ligand 19 (CCL19) and 21 (CCL21) mediate cell migration and angiogenesis in many diseases. However, these ligands' precise pathological role in ankylosing spondylitis (AS) has not been elucidated. The objective of this study was to examine the expression of CCL19 and CCL21 ...
Nakamura Shinsuke S Molecular Pharmacology, Department of Biofunctional Evaluation, Gifu Pharmaceutical University, 1-25-4 Daigaku-nishi, Gifu, 501-1196, - - 2014
Purpose:The incidence of blindness is increasing, in part, because of the abnormal ocular neovascularization. Anti-VEGF therapies have yielded impressive results; however, they are not a cure for blindness. Recently, metallothioneins (MTs) 1 and 2 have been implicated in the process of angiogenesis. Therefore, we investigated whether MT 1 and MT ...
Zhao Ruibo R Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, 410008, China, - - 2014
The objective of this study is to explore the effect of mmu-miR-142-5p on osteoblast and the mechanism. Neonatal New Zealand rabbits were selected to collect and culture primary osteoblasts after being killed. The agonists agomiR-142-5p, agomiR-NC and inhibitors antagomiR-142-5p, antagomiR-NC were transfected to establish mmu-miR-142-5p osteoblast model. 48 h after transfection, ...
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