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Fu Shaoyin S College of Animal Science, Inner Mongolia Agricultural University, Hohhot 010018, China; Key Laboratory of Animal Genetics, Breeding and Reproduction, Inner Mongolia Autonomous Region, Hohhot 010018, China; Institute of ATCG, Nei Mongolia Bio-Information, Hohhot 010020, China; Inner Mongolia Academy of Agricultural & Animal Husbandry Sciences, Hohhot 010031, - - 2014
Melatonin and microRNAs (miRNAs) play important roles in regulating hair follicle development. However, the effect of melatonin on the expression pattern of miRNAs in skin and follicle of cashmere goats remain largely undefined. To explore the mechanism of melatonin affecting cashmere growth mediated by miRNAs, the effect of melatonin implants ...
Li Ning N Department of Medical Oncology, Henan Cancer Hospital, Cancer Hospital Affiliated Zhengzhou University, Zhengzhou University, 127 Dongming Road, Zhengzhou, - - 2015
The purpose of this study was to evaluate expression and prognostic impact of Nanog, Oct4, Sox2, proliferation cell nuclear antigen (PCNA), Ki67 and E-cadherin in patients with gastric cancer (GC) by immunohistochemistry. A total of 69 patients were recruited who underwent gastrectomy between 2008 and 2009. We found that expression ...
Liu Ning-Ning NN The Department of Ophthalmology, the First Affiliated Hospital of China Medical University, Shenyang, Liaoning Province, - - 2014
To explore the anti-angiogenesis mechanism of Rofecoxib and determine whether Rofecoxib can be a therapeutic agent for the prevention of retinal neovascularization using a model of retinopathy of prematurity (ROP). ROP was induced by exposing mice to 75% oxygen from postnatal day 7 (P7 ) to P12 , then to ...
Paneni Francesco F Cardiology Unit, Department of Medicine, Karolinska University Hospital, Stockholm, - - 2014
-Cellular studies showed that histone methyltransferase Set7 mediates high glucose-induced inflammation via epigenetic regulation of the transcription factor NF-kB. However, the link between Set7 and vascular dysfunction in patients with diabetes remains unknown. This study was designed to investigate whether Set7 contributes to vascular dysfunction in patients with type 2 ...
Ma Liqiang L Institute of Laboratory Medicine, Fuzhou General Hospital (Dongfang Hospital), 156 North Xi-er Huan Road, Fuzhou City, 350025, Fujian Province, - - 2015
Cyclin D1 (CCND1) plays essential roles in cancer progression. In this study, CCND1 expression patterns in 211 cases of resected gastric adenocarcinoma (RGA) tissue were determined by immunohistochemistry, and the association between CCND1 expression levels and RGA prognosis was analyzed. RGA tissues displayed differential CCND1 expression (high expression, 52.1 %; n = 110, ...
Su Fangju F Department of Cardiology, Lanzhou General Hospital, People's Liberation Army, Lanzhou, Gansu 730050, P.R. - - 2014
Atrial interstitial fibrosis plays a dual role in inducing and maintaining atrial fibrillation (AF). Hypoxia-inducible factor-1α (HIF-1α) has been reported as closely associated with renal, liver and pulmonary fibrosis diseases. However, whether HIF-1α is involved in myocardial fibrosis, and the associations between HIF-1α, transforming growth factor-β1 (TGF-β1) and matrix metalloproteinase-9 ...
Løvendorf Marianne B MB Department of Dermato-Allergology, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark; LEO Pharma A ⁄ S, Ballerup, - - 2014
Psoriasis is a systemic disease with cutaneous manifestations. MicroRNAs (miRNAs) are small non-coding RNA molecules that are differentially expressed in psoriatic skin; however, only few cell and region specific miRNAs have been identified in psoriatic lesions. We used laser capture microdissection (LCM) and next-generation sequencing (NGS) to study the specific ...
Orvieto Raoul - - 2014
BackgroundOvarian hyperstimulation syndrome (OHSS), is characterized by marked ovarian enlargement and acute third space fluid sequestration that almost always develops after hCG administration or in early pregnancy. OHSS is similar to vascular leak syndrome (VLS), which may be attributable to the massive increase in systemic inflammatory cytokines. In the present ...
Zhang Fuquan - - 2014
Previous findings are inconsistent; yet, converging evidence suggests an association between schizophrenia (SZ) and the impairment of posttranscriptional regulation of brain development through microRNA (miRNA) systems. This study aims to (1) compare the overall frequency of 121 rare variants (RVs) in 59 genes associated with the miRNA system in genome-wide ...
Du Xin'Ai X Institute of Endemic Diseases, Key Laboratory of Environment and Genes Related to Diseases of Education Ministry, Xi'an Jiaotong University Health Science Center, No.76 Yanta West Road, Xi'an, Shaanxi 710061, - - 2014
To investigate the relationship between SEPS1 polymorphism and PI3K/Akt signaling pathway in KBD and further explore the pathogenesis of KBD. PCR-RFLP was used to detect SEPS1 -105G>A polymorphism in 232 cases and 331 controls;The mRNA expression of SEPS1 in whole blood was detected using qRT-PCR The protein expressions of PI3K/Akt ...
Fukusato Toshio T Department of Pathology, Teikyo University School of Medicine, Tokyo, - - 2014
Recent studies have indicated that hepatocellular adenoma (HCA) is a heterogenous group of benign tumors with various genetic and clinicopathological characteristics. We delineated the clinicopathological characteristics of HCA subtypes and evaluated the expression of transporter protein OATP1B3 in HCAs. HCAs in 34 Japanese patients were investigated immunohistochemically and classified into ...
Liu Ge G Department of Genomic Epidemiology, Research Center for Environment and Developmental Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, - - 2014
Dioxins are persistent environmental pollutants that cause multiple adverse health effects in humans, mainly through binding to the ligand-activated transcription factor, aryl hydrocarbon receptor (AhR). Genetic variation in AhR may modulate the susceptibility to dioxins. In this study, we aimed to evaluate the effects of the single nucleotide polymorphism (SNP) ...
Xu Jie J Bachelor Degree, Department of Stomatology, Hubei University of Science and - - 2014
Background: The accumulation of advanced glycation end products (AGEs) appears to be the main factors responsible for modulating periodontal inflammation in diabetes. The aim of the study is to examine the effects of AGEs on human periodontal ligament cells inflammation and to investigate the mechanism with a specific emphasis on ...
Li Jian - - 2014
Gefitinib, an EGFR-tyrosine kinase inhibitor, significantly improve prognosis in patients with advanced non-small cell lung cancer (NSCLC). The aim of this study was to evaluate the usefulness of MUC1 and vascular endothelial growth factor (VEGF) mRNA expression in peripheral blood as means of predicting benefit from gefitinib therapy in NSCLC ...
Zou Yaguang Y Department of Stomatology, NanFang Hospital, Southern Medical University, Guangzhou, 510515, - - 2014
Periodontitis, a common chronic inflammatory disease of the periodontium, is caused by dental plaque formation induced by microorganisms. Recent studies have demonstrated that lncRNAs play a critical role in the regulation of gene expression and in the pathogenesis of diseases. To demonstrate that periodontitis is associated with lncRNAs, microarray analysis ...
Mohammed-Geba Khaled K Departamento de Biología Marina y Acuicultura, Instituto de Ciencias Marinas de Andalucía, Consejo Superior Investigaciones Científicas (CSIC), 11510, Puerto Real, Cádiz, Spain, - - 2014
To assess the role of the GH/IGF-I axis in osmotic acclimation of the gilthead seabream Sparus aurata, juvenile specimens were acclimated to four environmental salinities: hyposmotic (5 ‰), isosmotic (12 ‰) and hyperosmotic (40 and 55 ‰). The full-length cDNAs for both pituitary adenylate cyclase-activating peptide (PACAP) and prepro-somatostatin-I (PSS-I), the precursor for ...
Chen Lin L Department of Anesthesia, Southwest Hospital, The Third Military Medical University, Chongqing, - - 2014
Background: Hepatopulmonary syndrome (HPS) is a serious complication of advanced liver disease that is characterised by intrapulmonary vascular dilatation (IPVD) and arterial hypoxemia. Pulmonary vascular remodelling (PVR) is an important pathological feature of HPS, but the potential mechanisms underlying PVR remain undefined. Recent findings have established the essential role of ...
Han Soon Young SY Department of Otolaryngology, Keimyung University School of Medicine, Daegu, - - 2014
The microRNAs have been implicated in the development and function of the inner ear, especially in contribution to hearing. However, the impact of idiopathic sudden sensorineural hearing loss (SSNHL) on expression of miRNA biogenesis-related components has not been established. To investigate the regulations of microRNA (miRNA) biogenesis-related components, argonaute 2 ...
Crago Jordan J School of Freshwater Sciences, University of Wisconsin-Milwaukee, Milwaukee, WI, 53204, USA, - - 2014
In this study, male fathead minnows (FHM) (Pimephales promelas) and juvenile rainbow trout (RT; Oncorhynchus mykiss) were exposed to two different surfactant mixtures of analytical-grade nonlyphenol, 4-tert octyphenol, octylphenol ethoxylates, nonylphenol ethoxylates, and the herbicide 2,4-dichlorophenoxyacetic acid (2,4-D). After a 7-days exposure to environmentally relevant concentrations of these compounds, there ...
He Deng D Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. - - 2014
The present study aimed to identify the characteristics and cross‑talk between transforming growth factor β1 (TGF‑β1) and calcium ions in nephrolithiasis patients with idiopathic hypercalciuria (IH) in order to elucidate the potential mechanisms underlying changes in cell phenotype induced by bone‑associated factors and their influence on renal nephrolithiasis formation. Blood samples ...
Shen Wenjun W Department of Pediatric Surgery, Children's Hospital of Fudan University, Shanghai 201102, China. Electronic address: - - 2014
MicroRNAs (miRNAs) are short, noncoding RNA molecules that act as post-transcriptional negative regulators of target mRNAs. Increasing evidence suggests that miRNAs are involved in liver fibrotic processes. Biliary atresia (BA) is characterized by rapid and progressive liver fibrosis. Therefore, we investigated the role of miRNA-21in the pathogenesis of BA. We ...
Shen Xiao-Ming XM Department of Oncology, Suzhou Xiangcheng People's Hospital, Suzhou, 215131, Jiangsu Province, - - 2014
The aim was to determine changes in dihydropyrimidine dehydrogenase (DPD) and thymidylate synthase (TS) mRNAs in the blood of advanced gastric cancer (AGC) patients to see whether these enzymes affected the patients' response to S-1-based chemotherapy and prognosis. For this purpose, pretreatment DPD/TS mRNA expressions were determined in 40 AGC ...
Jevalikar Ganesh S - - 2014
Abstract Objective: We analyzed mRNA expression of X-linked inhibitor of apoptosis protein (XIAP) in patients with Turner syndrome (TS) and examined its association with phenotypic features. Subjects and methods: XIAP mRNA expression levels were investigated in 98 patients with TS in total RNA extracted from blood leucocytes by real time ...
Hsu Chin-Mu CM Terry Fox Cancer Research Laboratory, China Medical University Hospital, Taichung, Taiwan, - - 2014
Background/Aim: The altered cellular repair capacity plays a critical role in genomic instability and carcinogenesis. We aimed at evaluating the contribution of the polymorphic variant in apurinic/apyriminidinic endonuclease (APEX1) gene to its mRNA and protein levels and the risk of endometriosis. Patients and Methods: In the current case-control study, 153 ...
Luo Zhenhua Z Department of Periodontics, School of Stomatology, Capital Medical University, Beijing, - - 2014
The objective of this study was to investigate the expression level, clinical significance, and possible regulating role of IL-17F in patients of chronic periodontitis. Periodontal local tissues were obtained from chronic periodontitis (CP) and healthy controls (HC) for real-time PCR (RT-PCR) detection with IL-17F and IL-17A messenger RNA (mRNA). Primary ...
Iwamoto Naoki N Division of Rheumatology, Center of Experimental Rheumatology, University Hospital and Zurich Center of Integrative Human Physiology (ZIHP), Zurich, Switzerland Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, - - 2014
To investigate the role of microRNA-193b-3p (miR-193b) in the vascular pathophysiology of systemic sclerosis (SSc). Expression of miR-193b in skin biopsies and fibroblasts from patients with SSc and normal healthy (NH) controls were determined by real-time PCR. Transfection with miR-193b precursor and inhibitor were used to confirm targets of miR-193b. ...
Romero-Martínez A A University of Valencia, - - 2014
It has been hypothesized that anger expression may be associated with increased salivary immunoglobulin A (sIgA) levels, which is associated with decreased somatic symptoms, and therefore anger expression may be associated with reduced somatic symptoms in intimate partner violence (IPV) perpetrators. This study tested the potential mediating effect of sIgA ...
Zhao An A Department of Urology, University Hospital of Saint-Etienne, Jean Monnet University, France; Zhejiang Cancer Research Institute, Zhejiang Province Cancer Hospital, Hangzhou, - - 2014
There is limited research on cell-free RNA (cf-RNA) in the urine of cancer patients. The present study was performed to detect the cf-RNA in the urine of clear cell renal cell carcinoma (ccRCC). 95 urine samples from ccRCC patients and 50 urine samples from control subjects were analyzed. The cf-RNA ...
Zhu Jiang J Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, Sichuan, P.R. China ; Department of Neurosurgery, Sichuan Cancer Hospital, Chengdu, Sichuan, P.R. - - 2015
The aim of the present study was to investigate the significance of survivin protein expression levels in craniopharyngioma. Tumor samples and clinical data were obtained from 50 patients with craniopharyngioma who were admitted to the West China Hospital of Sichuan University (Chengdu, China). The morphology of the craniopharyngioma samples was ...
Kumar Ashutosh A Institute of Life Sciences, School of Science and Technology, Ahmedabad University, University Road, Navrangpura, Ahmedabad 380009, Gujarat, India Department of Biotechnology, Integral University, Dasauli, P.O. Bas-ha Kursi Road, Lucknow 226026, - - 2014
Zinc oxide (ZnO) nanoparticles are the mostly used engineered metal oxide nanoparticles in consumer products. This has increased the likelihood of human exposure to this engineered nanoparticle (ENPs) through different routes. At present, the majority of the studies concerning ZnO ENPs toxicity have been conducted using in vitro and in ...
Li Hao-Bo HB Oral Medicine Department, Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, P.R. - - 2015
hMSH2 is one of the human DNA mismatch repair genes that plays an important role in reducing mutations and maintaining genomic stability. The aim of the present study was to detect the expression and significance of hMSH2 protein in patients with oral lichen planus (OLP). The expression levels of hMSH2 ...
Arai Haruna H Department of Nephrology, Fujita Health University School of Medicine, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi, 470-1192, - - 2014
Renal parenchymal lesions in patients with IgG4-related kidney disease (IgG4-RKD) are characterized by tubulointerstitial nephritis with storiform fibrosis and infiltration by high numbers of IgG4-positive plasma cells. The aim of this study was to evaluate the clinical and pathological effects of corticosteroid therapy in patients with IgG4-RKD. Of six patients ...
Gui Dongmei D Department of Ophthalmology, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, P.R. - - 2014
This study aimed to investigate the impacts of erythropoietin (EPO) on the electroretinogram b‑wave (ERG‑b), and on the mRNA and protein expression levels of hypoxia‑inducible factor‑1α (HIF‑1α), inducible nitric oxide synthase (iNOS), cyclooxygenase‑2 (COX‑2) and caspase‑9 in chronic ocular hypertension rats. Episcleral vein cauterization (EVC) was used to establish the ...
Yan Wei W Beijing Neurosurgical Institute, Capital Medical University, Beijing, PR China. Department of Neurosurgery, First Affiliated Hospital of Nanjing Medical University, Nanjing, PR - - 2014
MicroRNAs (miRNAs) are directly involved in the progression in various cancers. To date, no systematic researches have been performed on the expression pattern of miRNA during progression from low grade gliomas to anaplastic gliomas or secondary glioblastomas and those prognostic miRNAs in anaplastic gliomas and secondary glioblastomas. In the present ...
Zheng Huifeng H Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, - - 2014
Gastrodin, as one of the major components extracted from the Chinese herb Gastrodia elata Bl., has many biologic effects, one of which is anti-apoptosis. Apoptosis is considered to be one of the pathogenetic mechanisms in steroid-induced osteonecrosis of the femoral head (ONFH). Therefore, we performed this study to investigate whether ...
Frodl Thomas T Trinity College - - 2014
Alterations of the glucocorticoid system and of hippocampal volumes have consistently been reported in patients with major depressive disorders (MDD). The aim of the present study was to investigate whether the messenger RNA (mRNA) expression of glucocorticoid inducible genes is associated with changes in the cornu ammonis (CA) and dentate ...
Dilek Nursel N Department of Dermatology, Recep Tayyip Erdoğan University, Medical Faculty Hospital, Rize, - - 2014
Iron is an essential nutrient for mammals. Accelerated loss of nutrients through hyperproliferation and desquamation from the skin in psoriasis is known. Hepcidin is an important and recently discovered regulator of iron homeostasis. The present study was undertaken to investigate the hepcidin expression in psoriasis patients. We examined peripheral blood ...
Park Jong Sun - - 2014
Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease of unknown causes. Three proteins (mammalian target of rapamycin, mTOR; zinc finger E-box-binding homeobox 1, ZEB1; Rho-associated, coiled-coil containing protein kinase 1, ROCK1) may be related to pulmonary fibrosis. However, they have not been assessed in human pulmonary fibrosis. We assessed ...
Miyahara Yuki Y Department of Pediatrics, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, Suita City, Osaka, - - 2014
To characterize cholesterol regulation in the liver of patients with Alagille syndrome (AGS). Serum total cholesterol (TC) and total bile acid (TBA) levels were measured in 23 AGS patients. The expressions of genes involved in cholesterol regulation, including low-density lipoprotein receptor (LDLR), scavenger receptor class B type I (SR-BI), 3-hydroxy-3-methylglutaryl ...
Shen Mo M Department of Laboratory Medicine, The First Affiliated Hospital of Wenzhou Medical University, Zhejiang 325000, P.R. - - 2014
Bladder cancer (BCa) is the most common tumor of the urinary system. Chronic inflammation in the papillary urothelial neoplasm of low malignant potential (PUNLMP)may contribute to carcinogenesis, including that of BCa, via poorly understood mechanisms. In this study, we show that the lymphotoxin β receptor (LTβR) is upregulated in BCa via ...
Mottier Antoine A Normandie Université, Université de Caen Basse-Normandie, F-14032 Caen, France; UMR BOREA (Biologie des Organismes et des Ecosystèmes Aquatiques), MNHN, UPMC, UCBN, CNRS-7208, IRD-207, IBFA, Université de Caen Basse-Normandie, Esplanade de la Paix, CS 14032, 14032 Caen Cedex 5, - - 2014
Glyphosate-based herbicides are extensively used and can be measured in aquatic ecosystems, including coastal waters. The effect of glyphosate on non-target organisms is an issue of worldwide concern. The aim of this study was to investigate the effects of subchronic exposure to glyphosate in juvenile oysters, Crassostrea gigas. Yearling oysters ...
Xiao Yongtao Y Department of Pediatric Surgery, Xin Hua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China; Shanghai Institute of Pediatric Research, Shanghai, China; Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition, Shanghai, - - 2014
Cholestatic liver disease is associated with dysregulated expression of microRNAs (miRNAs). However, it remains unknown whether miRNAs are involved in the cholestasis-induced proliferation of cholangiocytes. In this study, we tested the hypothesis that miRNAs modulate cholangiocyte proliferation through effects on the IL-6 pathway, a known regulator of cholangiocyte proliferation. Expression ...
Katome Takashi T Department of Ophthalmology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan; Visual Research Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, - - 2014
To determine whether peroxisome proliferator-activated receptor gamma (PPARγ), which is recognized as a component of the exosomes circulating in plasma, is expressed intraocularly in patients with proliferative diabetic retinopathy (PDR). The concentrations of PPARγ and vascular endothelial growth factor (VEGF) in the aqueous humor and vitreous of 50 eyes with ...
Mahdian Soodeh S Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran; Department of Genetics, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, Academic Center for Education Culture and Research, Tehran, - - 2014
To evaluate the expression of MIF, CD74, and COX-2 in normal, ectopic, and eutopic endometrium during the menstrual cycle and to assess MIF level in peripheral blood. The expressions of MIF, CD74, and COX-2 in normal, ectopic, and eutopic endometrium were evaluated with the use of real-time polymerase chain reaction. ...
Fichna Marta M Department of Endocrinology and Metabolism, Poznan University of Medical Sciences , Poznan , Poland - - 2014
Abstract Autoimmune Addison's disease (AAD) results from T cell-mediated destruction of the adrenal cortex, commonly accompanied by autoantibodies to 21-hydroxylase (21OH). In order to gain insight into the obscure aetiology of this disease, we investigated the roles of the IL2 and IL2RA genes, encoding interleukin-2 and subunit alpha of its ...
Subash-Babu Pandurangan P Molecular Biology Research Lab, Department of Food and Nutrition, College of Food and Agricultural Sciences, King Saud University, Riyadh, 11451, Kingdom of Saudi Arabia. - - 2014
We aimed to explore the antiadipogenic and adipolysis effect of hesperetin in human mesenchymal stem cells (hMSCs)-induced adipogenesis. IC50 value of hesperetin was higher for hMSCs such as 149.2 ± 13.2 μmol for 24 h and 89.4 ± 11.4 μmol in 48 h, whereas in preadipocytes was 87.6 ± 9.5 ...
Shamsabadi Reza Mahvelati RM Department of Orthodontics, School of Dentistry, Hamedan University of Medical Sciences, Hamedan, - - 2014
Oral pemphigus vulgaris (PV) is a rare blistering disorder of the skin and mucous membranes in the mouth. Inflammasome serves as a molecular platform that mediates the autoactivation of caspase-1, which cleaves the pro-forms of IL-1β and IL-18 to active forms. Therefore, the main aim of this study was to ...
Hong Fanzhen F Department of Obstetrics and Gynaecology, The Second Hospital of Shandong University, Jinan, China - - 2014
To detect microRNA (miR)-126 expression and its correlation with vascular endothelial growth factor (VEGF) levels in placentas from patients with pre-eclampsia compared with those from normotensive pregnancies. miR-126 expression, and VEGF mRNA and protein levels, in placentas collected sequentially from patients with pre-eclampsia and normotensive pregnancies were measured using real-time ...
Korzeniewski Nina N Section of Molecular Urooncology, Department of Urology, University of Heidelberg School of Medicine, Heidelberg, - - 2014
Current methods for the early detection of prostate cancer (PCa), in particular prostate-specific antigen screening, are likely to benefit from complementary molecular analyses to enhance specificity. MicroRNAs (miRNA) are small endogenously expressed noncoding RNAs that negatively regulate the expression of protein-coding genes at the transcriptional or translational level. Accumulating evidence ...
Konosu-Fukaya Sachiko S Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, - - 2014
It has become important to evaluate the possible involvement of 3β-hydroxysteroid dehydrogenase type 1 (HSD3B1) and 2 (HSD3B2) isoforms in aldosterone-producing adenoma (APA). In this study, we studied 67 and 100 APA cases using real-time quantitative PCR (qPCR) and immunohistochemistry, respectively. Results of qPCR analysis demonstrated that HSD3B2 mRNA was ...
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