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Seiliez Iban I INRA, UR1067 Nutrition Métabolisme Aquaculture, F-64310, St-Pée-sur-Nivelle, - - 2014
The extraordinary muscle growth potential of teleost fish, particular those of the Salmoninae clade, elicits questions about the regulation of the relatively highly conserved transcription factors of the myogenic program. The pseudotetraploid nature of the salmonid genome adds another layer of regulatory complexity that must be reconciled with epigenetic data ...
Graf Martin M Department of Biological Sciences and Centre for Bioimaging Sciences, National University of Singapore, 14 Science Dr 04, Singapore - - 2014
Dmrt transcription factors control sex determination or sex-specific differentiation across all invertebrate and vertebrate species, where they have been studied so far. Besides important functions in the reproductive system, also non-gonadal roles have been assigned to several dmrt family members. One example is dmrt5 that was shown to guide neurogenesis ...
Ben-Haim Moshe Shay MS 1] Sheba Cancer Research Center, Chaim Sheba Medical Center, Tel Hashomer, 52621 Israel [2] Sackler School of Medicine, Tel Aviv University, Tel Aviv, 69978 - - 2014
Polymorphism of the FTO gene encoding an N-methyladenosine (mA) RNA demethylase was robustly associated with human obesity; however, the mechanism by which FTO affects metabolism, considering its emerging role in RNA modification, is still poorly understood. A new study published in Cell Research reports novel functions implicating FTO in the ...
Hamzeh Mona T MT University of - - 2014
Extracellular matrix (ECM) proteins, especially fibronectin, are critical pathological characteristics of renal fibrosis and contribute to the progression of chronic renal disease. Recent studies showed that β1 integrin is associated with the development of renal fibrosis in a murine model of unilateral ureteral obstruction (UUO). However, the molecular events responsible ...
Kalla R R Gastrointestinal Unit, Centre for Molecular Medicine, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, - - 2014
MicroRNAs (miRNAs) are small non-coding RNAs, 18-23 nucleotides long, which act as post-transcriptional regulators of gene expression. miRNAs are strongly implicated in the pathogenesis of many common diseases, including IBDs. This review aims to outline the history, biogenesis and regulation of miRNAs. The role of miRNAs in the development and ...
Kiyma Z Z OGU, Eskisehir, - - 2014
Hyaluronan (HA; hyaluronic acid), a member of glycosaminoglycans (GAG) family, is the main polysaccharide and is expressed in almost all tissues including those of the reproductive tract. Three different hyaluronic acid-synthase (HAS) enzymes, HAS1, HAS2, and HAS3, synthesise HA. The action of HA depends on its molecular size and its ...
Salton Maayan M National Cancer Institute, NIH, Bethesda, MD 20892, USA - - 2014
Recent evidence points to a role of chromatin in regulation of alternative pre-mRNA splicing (AS). In order to identify novel chromatin regulators of AS, we screened an RNAi library of chromatin proteins using a cell-based high-throughput in vivo assay. We identified a set of chromatin proteins that regulate AS. Using ...
Garcia-Moreno Manuel M Centro de Biología Molecular "Severo Ochoa" (CSIC-UAM), C/Nicolás Cabrera 1, Universidad Autónoma de Madrid, Cantoblanco, Madrid 28049, Spain mgmoreno@cbm.csic.es - - 2014
Translation initiation of alphavirus subgenomic mRNA (sgmRNA) can occur in the absence of several initiation factors (eIFs) in infected cells; however, the precise translation mechanism is still poorly understood. In this study, we have examined the mechanism of initiation and AUG selection in Sindbis virus (SINV) sgmRNA. Our present findings ...
Cattenoz Pierre B PB Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France; Centre National de la Recherche Scientifique, UMR7104, Illkirch, France; Institut National de la Santé et de la Recherche Médicale, U964, Illkirch, France; Université de Strasbourg, Illkirch, - - 2014
Powerful transcription factors called fate determinants induce robust differentiation programs in multipotent cells and trigger lineage specification. These factors guarantee the differentiation of specific tissues/organs/cells at the right place and the right moment to form a fully functional organism. Fate determinants are activated by temporal, positional, epigenetic and post-transcriptional cues, ...
Lee Sang In SI Animal Biotechnology Division, National Institute of Animal Science, Rural Development Administration, Suwon, 441-706, Republic of - - 2014
Early chick development is a systematic process governed by the concerted action of multiple mechanisms that regulate transcription and post-transcriptional processes. Post-transcriptional microRNA-mediated regulation, with regard to lineage specification and differentiation in early chick development, requires further investigation. Here, we characterize the transcriptional and post-transcriptional regulation mechanisms in undifferentiated chick ...
Wertz Ingrid E IE Departments of Molecular Oncology and Early Discovery Biochemistry, Genentech, Inc., 1 DNA Way, M/S 40, South San Francisco, CA 94080, United States. Electronic address: - - 2014
The Tumor Necrosis Factor Receptor-1 (TNFR1) is a central regulator of inflammation, cell death, and cellular proliferation. As such, alterations in TNFR1 signaling are associated with numerous diseases ranging from autoimmune syndromes to cancer. Understanding the regulation of TNFR1 signaling is therefore of considerable importance. The transduction of signaling events ...
Laskar Shyamasree S Department of Biotechnology and Bioinformatics, School of Life Sciences, University of Hyderabad, Hyderabad, - - 2014
The epigenetic writer Sir2 maintains the heterochromatin state of chromosome in three chromosomal regions, namely the silent mating-type loci, telomeres, and the rDNA. Here we demonstrate the mechanism by which Sir2 is regulated under heat stressed condition. Our study reveals that a transient heat shock causes a drastic reduction in ...
Chang Hsin-Wen HW Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14850, - - 2014
Recent findings in diverse organisms strongly support a conserved role for mitochondrial electron transport chain dysfunction in longevity modulation, but the underlying mechanisms are not well understood. One way cells cope with mitochondrial dysfunction is through a retrograde transcriptional reprogramming response. In this review, we primarily focus on the work ...
Hirayama Takashi T a Institute of Plant Science and Resources, Okayama - - 2014
Abstract Poly(A) status is the major determinant of mRNA stability, even in endosymbiotic organelles. Poly(A) specific ribonuclease (PARN) is distributed widely among eukaryotes and has been shown to regulate the poly(A) status of cytoplasmic mRNA in various organisms. Surprisingly, our recent study revealed that PARN also directly regulates poly(A) status ...
Chanut-Delalande Hélène H 1] Centre de Biologie du Développement, Université de Toulouse, UPS, 31062 Toulouse cedex 9, France [2] CNRS, UMR5547, Centre de Biologie du Développement, Toulouse, 31062 cedex 9, - - 2014
Animal development fundamentally relies on the precise control, in space and time, of genome expression. Whereas we have a wealth of information about spatial patterning, the mechanisms underlying temporal control remain poorly understood. Here we show that Pri peptides, encoded by small open reading frames, are direct mediators of the ...
Shim Jae Sung - - 2014
Many of the developmental responses and behaviors in plants that occur throughout the year are controlled by photoperiod; among these, seasonal flowering is the most characterized. Molecular genetic and biochemical analyses have revealed the mechanisms by which plants sense changes in day length to regulate seasonal flowering. In Arabidopsis thaliana, ...
Lin Chengyuan C School of Biological Sciences, University of Hong Kong, Hong Kong; YMU-HKBU Joint Laboratory of Traditional Natural Medicine, Yunnan Minzu University, Kunming, - - 2014
Prolactin (PRL), a pituitary hormone with diverse functions, is well-documented to be under the control of both hypothalamic and peripheral signals. Intrapituitary modulation of PRL expression via autocrine/paracrine mechanisms has also been reported, but similar information is still lacking in lower vertebrates. To shed light on autocrine/paracrine regulation of PRL ...
Liang Xin-Li XL Key Laboratory of Modern Preparation of TCM of Ministry of Education, Jiangxi University of TCM, Nanchang, 330004, PR - - 2014
Radix Angelicae Dahuricae is the dried root of Angelicae Dahurica (Fisch.ex Hoffm.)Benth.et Hook.f. var.formosana (Boiss.) Shan et Yuan (Fam.Umbelliferae). The total coumarins (Cou) and volatile oil (VO) were main active components that drived from Radix Angelicae Dahuricae. Our previous studies have shown that Cou and VO could increase intestinal absorption ...
Wang Yanwei Y Central Laboratory, Yuhuangding Hospital, Yantai, Shandong Province, PR - - 2014
Stress-inducible protein 1 (Stip1) is one of the well-studied co-chaperones, although limited researches have been conducted in testis and epididymis. Here we found that Stip1 was ubiquitously expressed in various human tissues, including the testis and epididymis. In human testis and epididymis, Stip1 was localized in the cytoplasm of diverse ...
Yu Zhenming Z Department of Biology, University of Pennsylvania, Philadelphia, PA - - 2014
Expanded non-coding RNA repeats of CUG and CCUG are the underlying genetic causes for myotonic dystrophy type 1 (DM1) and type 2 (DM2), respectively. A gain-of-function of these pathogenic repeat expansions is mediated at least in part by their abnormal interactions with RNA binding proteins such as MBNL1 and resultant ...
Peternelj Tina Tinkara TT a Antioxidant Research Group, School of Human Movement Studies, The University of Queensland, Brisbane, QLD, - - 2014
A growing body of evidence demonstrates the involvement of protein modification with O-linked β-N-acetylglucosamine (O-GlcNAc) in the stress response and its beneficial effects on cell survival. Here we investigated protein O-GlcNAcylation in skeletal muscle cells exposed to oxidative stress and the crosstalk with endogenous antioxidant system. The study focused on ...
Jiang Jinhua J State Key Laboratory Breeding Base for Zhejiang Sustainable Pest and Disease Control, Institute of Quality and Standard for Agro-products, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, Zhejiang, China; Key Laboratory for Pesticide Residue Detection of Ministry of Agriculture, Institute of Quality and Standard for Agro-products, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, Zhejiang, - - 2014
Carbendazim is one of the most widespread environmental contaminant that can cause major concern to human and animal reproductive system. To date, very few studies have been conducted on the toxic effect of carbendazim in the non-target organism zebrafish (Danio rerio). The study presented here aimed to assess how carbendazim ...
Vrtačnik Peter P University of Ljubljana, Faculty of Pharmacy, Department of Clinical Biochemistry, Ljubljana, - - 2014
Estrogens have long been known as important regulators of the female reproductive functions; however, our understanding of the role estrogens play in the human body has changed significantly over the past years. It is now commonly accepted that estrogens and androgens have important functions in both female and male physiology ...
Caroll Jean J Genome Damage and Stability Center, University of Sussex, Brighton, BN1 9RQ, - - 2014
Aprataxin (APTX) deficiency causes progressive cerebellar degeneration, ataxia, and occulomotor apraxia in man. Cell free assays and crystal structure studies demonstrate a role for APTX in resolving 5'-adenylated nucleic acid breaks, however APTX function in vertebrates remains unclear due to the lack of an appropriate model system. Here we generated ...
Zhang Dingwei D Department of Dermatology, The Second Affiliated Hospital of Xi'an Jiaotong University, 157 Xiwu Road, Xi'an, Shaanxi, 710004, People's Republic of - - 2014
Hailey-Hailey disease (HHD) is caused by heterozygous mutations in the ATP2C1 gene, encoding the secretory pathway Ca(2+) ATPase1 (SPCA1). SPCA1 and sarco/endoplasmic reticulum Ca(2+) ATPase2 (SERCA2) encoded by ATP2A2 are two essential calcium pumps needed for Ca(2+) homeostasis maintenance in keratinocytes. ATP2A2 mutations cause another hereditary skin disorder, Darier's disease ...
Soyano Takashi T National Institute for Basic Biology, Okazaki, Aichi 444-8585, Japan; National Institute of Agrobiological Sciences, Tsukuba, Ibaraki 305-8602, - - 2014
Autoregulatory negative-feedback loops play important roles in fine-balancing tissue and organ development. Such loops are composed of short-range intercellular signaling pathways via cell-cell communications. On the other hand, leguminous plants use a long-distance negative-feedback system involving root-shoot communication to control the number of root nodules, root lateral organs that harbor ...
Roberto V P VP Centre of Marine Sciences, University of Algarve, Faro, Portugal; PhD Program in Biomedical Sciences, DCBM, University of Algarve, Portugal. Electronic address: - - 2014
MicroRNAs (miRNAs) provide a mechanism for fine-tuning of intricate cellular processes through post-transcriptional regulation. Emerging evidences indicate that miRNAs play key roles in regulation of osteogenesis. The miR-29 family was previously implicated in mammalian osteoblast differentiation by targeting extracellular matrix molecules and modulating Wnt signaling. Nevertheless, the function of miR-29 ...
Alli Shaik Asfa - - 2014
Zebrafish is a popular system for studying vertebrate development and disease, and shows high genetic conservation with humans. Molecular level studies at different stages of development are essential for understanding the mechanisms deployed during ontogeny. Here, we performed comparative analysis of whole proteome and transcriptome at early-stage (24 hours post ...
Henry Rebecca J RJ Physiology, School of Medicine, National University of Ireland, Galway, Ireland; NCBES Centre for Pain Research and Neuroscience Centre, National University of Ireland, Galway, - - 2014
The present study examined the effect of enhancing fatty acid amide hydrolase (FAAH) substrate levels in vivo on Toll-like receptor (TLR)3-induced neuroinflammation. Systemic and central (i.c.v.) administration of the FAAH inhibitor URB597 increased hippocampal levels of the N-acylethanolamines palmitoylethanolamide and oleoylethanolamide, but not anandamide. Systemic URB597 increased IFNα, IFNγ and ...
Brouwer Stephan S Department of Molecular Bacteriology, Helmholtz Center for Infection Research, Braunschweig, - - 2014
Regulation of gene expression plays a key role in bacterial adaptability to changes in the environment. An integral part of this gene regulatory network is achieved via quorum sensing (QS) systems that coordinate bacterial responses under high cellular densities. In the nosocomial pathogen Pseudomonas aeruginosa the 2-alkyl-4-quinolone (pqs) signaling pathway ...
Gao Xuefei X Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1HH, - - 2014
The transcription activator-like effectors (TALEs) and the RNA-guided clustered regularly interspaced short palindromic repeat (CRISPR) associated protein (Cas9) utlilize distinct molecular mechanisms in targeting site recognition. The two proteins can be modified to carry additional functional domains to regulate expression of genomic loci in mammalian cells. In this study, we ...
Nousch Marco M Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG), Pfotenhauerstrasse 108, Dresden, 01307, - - 2014
Post-transcriptional gene regulation mechanisms decide on cellular mRNA activities. Essential gatekeepers of post-transcriptional mRNA regulation are broadly conserved mRNA-modifying enzymes, such as cytoplasmic poly(A) polymerases (cytoPAPs). Although these non-canonical nucleotidyltransferases efficiently elongate mRNA poly(A) tails in artificial tethering assays, we still know little about their global impact on poly(A) metabolism ...
Wellhauser Leigh L Department of Physiology, University of Toronto, Toronto, Ontario, Canada, M5G - - 2014
Attesting to its intimate peripheral connections, hypothalamic neurons integrate nutritional and hormonal cues to effectively manage energy homeostasis according to the overall status of the system. Extensive progress in the identification of essential transcriptional and post-translational mechanisms regulating the controlled expression and actions of hypothalamic neuropeptides has been identified through ...
Fellous Alexandre A UMR BOREA Biologie des Organismes et Ecosystèmes Aquatiques, MNHN, UPMC, UCBN, CNRS-7208, IRD-207, Institut de Biologie Fondamentale et Appliquée, Université de Caen Basse-Normandie, Esplanade de la Paix, CS 14032, 14032 Caen cedex 5, - - 2014
In many groups, epigenetic mechanisms influence developmental gene regulation under environmental inputs. The Pacific oyster Crassostrea gigas belongs to lophotrochozoans and its larval development is highly dependent on temperature, but the role of epigenetic mechanisms in this context is unknown despite high levels of the recently characterized Jumonji histone demethylase ...
Shi Jianli J Molecular, Cellular, & Developmental Biology, University of Colorado Boulder, Boulder, Colorado - - 2014
Wnt signaling and ciliogenesis are core features of embryonic development in a range of metazoans. Chibby (Cby), a basal-body associated protein, regulates β-catenin-mediated Wnt signaling in the mouse but not Drosophila. Here we present an analysis of Cby's embryonic expression and morphant phenotypes in Xenopus laevis. Cby RNA is supplied ...
Wang Gang G Key Laboratory for Industrial Biocatalysis, Ministry of Education, Department of Chemical Engineering, Tsinghua University, Beijing, China, - - 2014
It is desirable to build a universal and efficient protein expression system for wild-type prokaryotic strains in biotechnology industry and the outstanding T7 expression system could be a good candidate. However, the current utilization of T7 system depends on the specific DE3 lysogenic hosts, which severely limits its application in ...
Bromgard Gregg G a Southern University at New - - 2014
The current study tested how culture may affect the interpretation of the expression of pride among Norwegian and U.S. participants. Our results show that participants from Norway ascribed more negative trait attributions to a target person expressing pride than U.S. participants. It is proposed that Janteloven is responsible for the ...
Oonuma Kouhei K Department of Biological Sciences, Graduate School of Science and Engineering, Tokyo Metropolitan University, 1-1 Minamiohsawa, Hachiohji, Tokyo 192-0397, - - 2014
Establishment of the anterior-posterior axis is an important event in the development of bilateral animals. A homeodomain transcription factor, Otx, is important for the formation of the anterior part of the embryo, and its mRNA is expressed in a continuous manner in a wide range of animals. This pattern of ...
Xiang Y Y Department of Ophthalmology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, - - 2014
Spinal microglia activation is one of the pathologic mechanisms involved in post-operative pain, which results from surgical injuries in skin, fascia, muscle and small nerves innervating these tissues. Recent research has shown that neuregulin-1 (NRG1) and its receptor erythroblastosis oncogene B (ErbB) family mediate microglia proliferation and chemotaxis contributing to ...
Lee Jeong Soon JS Department of Mechanical and Materials Engineering, University of Nebraska-Lincoln, Lincoln, NE, 68588, - - 2014
Poly(ADP-ribose) polymerase 1 (PARP1) contributes to fibrosis in several disease models. Recent in vivo data indicate that loss of PARP1 attenuates renal fibrosis and inflammation independent on transforming growth factor-β (TGF-β); however, the role of PARP1 in kidney tubular cells in response to tubulointerstitial fibrosis remains to be defined. Here, ...
Liao Xing-Hua XH Key Laboratory of Industrial Fermentation Microbiology, Ministry of Education and Tianjin, College of Biotechnology, Tianjin University of Science and Technology, P.R.China, 300457; Institute of Biology and Medicine, Wuhan University of Science and Technology, P.R.China, - - 2014
Myocardin is well known to play a key role in development of cardiomyocyte hypertrophy. But the exact molecular mechanism regulating myocardin stability and transactivity to affect cardiomyocyte hypertrophy has not been studied clearly. We now report that NF-κB (p65) can inhibit myocardin-induced cardiomyocyte hypertrophy. Then we explore the molecular mechanism ...
Weil Timothy T - - 2014
Localization and the associated translational control of mRNA is a well established mechanism for segregating cellular protein expression. Drosophila has been instrumental in deciphering the prevailing mechanisms of mRNA localization and regulation. This review will discuss the diverse roles of mRNA localization in the Drosophila germline, the cis-elements and cellular ...
Boštjančič Emanuela E Department of Molecular Genetics, Faculty of Medicine, Institute of pathology, University of Ljubljana, 1000 Ljubljana, Slovenia - - 2014
The heart is the first organ to function in the developing embryo. MicroRNAs (miRNAs) are small non-coding RNAs involved in the translational regulation of gene expression, which is beside transcriptional regulation crucial for the morphologic development of muscle tissue. The aim of our study was to test the hypothesis that ...
Schmidt Augusto F AF Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH, - - 2014
Background:Damage-associated molecular patterns (DAMPs) and antimicrobial peptides (AMPs) are components of pulmonary innate immunity and tissue repair. We hypothesized that DAMPs and AMPs would increase in response to fetal pulmonary inflammation caused by chorioamnionitis in a time-dependent manner.Methods:Fetal sheep were exposed to intra-amniotic saline or LPS (10mg) between 5 hours ...
Niedner Annika - - 2014
Asymmetric, motor-protein dependent transport of mRNAs and subsequent localized translation is an important mechanism of gene regulation. Due to the high complexity of such motile particles, our mechanistic understanding of mRNA localization is limited. Over the last two decades, ASH1 mRNA localization in budding yeast has served as comparably simple ...
Niedner Annika - - 2014
Asymmetric, motor-protein dependent transport of mRNAs and subsequent localized translation is an important mechanism of gene regulation. Due to the high complexity of such motile particles, our mechanistic understanding of mRNA localization is limited. Over the last two decades, ASH1 mRNA localization in budding yeast has served as comparably simple ...
Singer-Krüger Birgit B a Interfaculty Institute of Biochemistry; University of Tübingen; Tübingen, - - 2014
mRNA localization and localized translation is a common mechanism that contributes to cell polarity and cellular asymmetry. In metazoan, mRNA transport participates in embryonic axis determination and neuronal plasticity. Since the mRNA localization process and its molecular machinery are rather complex in higher eukaryotes, the unicellular yeast Saccharomyces cerevisiae has ...
Tsang Anthony H - - 2014
Abstract Endogenous circadian clocks facilitate the adaptation of physiology and behavior to recurring environmental changes brought about by the Earth's rotation around its axis. Adipose tissues harbor intrinsic circadian oscillators based on interlocked transcriptional-translational feedback loops built from a set of clock genes that regulate important aspects of lipid metabolism ...
Matkovich Scot J SJ Center for Pharmacogenomics, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110 smatkovi@dom.wustl.edu - - 2014
The vast majority of mammalian DNA does not encode for proteins but instead is transcribed into noncoding (nc)RNAs having diverse regulatory functions. The poorly characterized subclass of long ncRNAs (lncRNAs) can epigenetically regulate protein-coding genes by interacting locally in cis or distally in trans. A few reports have implicated specific ...
Lappas Martha M Mercy Perinatal Research Centre, Mercy Hospital for Women, Heidelberg, VIC, Australia; Obstetrics, Nutrition and Endocrinology Group, Department of Obstetrics and Gynaecology, University of Melbourne, Melbourne, VIC, - - 2014
Inflammation is commonly associated with preterm birth. In non-gestational tissues, the cellular inhibitor of apoptosis protein (cIAP) 1 and 2, independent of their role in apoptosis, have emerged as important regulators of inflammation. There is, however, no data on the effect of human labour on the expression of cIAPs in ...
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