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Ra┼żná Katarína K a Department of Genetics and Plant Breeding , Slovak University of Agriculture in Nitra , Slovak - - 2014
Corylus avellana is the source of inhalant allergies induced by hazel pollen as well as food allergies induced after ingestion of hazelnuts. In this study, real-time PCR approach was used to analyse expression of hazel pollen allergens on the molecular level. Relative quantity of hazelnut allergens Corylus avellana, L. CorA ...
Oliveria Seth Franklin - - 2014
Glial derived neurotrophic factor (GDNF) is a trophic factor for dopaminergic (DA) neurons, which is neuroprotective for DA neurons in animal models. GDNF is considered a potential treatment of Parkinson disease (PD) to slow disease progression. However, initial trials of direct delivery of GDNF protein to the brain for PD ...
Cambier Linda L Broad Center for Regenerative Medicine and Stem Cell Research, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, - - 2014
A complex regulatory network of morphogens and transcription factors is essential for normal cardiac development. Nkx2-5 is among the earliest known markers of cardiac mesoderm that is central to the regulatory pathways mediating second heart field (SHF) development. Here, we have examined the specific requirements for Nkx2-5 in the SHF ...
Ottaviani Silvia S S Ottaviani, Cancer Cell Biology Section Hammersmith Campus, Imperial College School of Medicine, London, W12 0NN, United - - 2014
Despite its identification over 100 years ago, new discoveries continue to add to the complexity of the regulation of the endocrine system. Today the nuclear receptors (NRs) that play such a pivotal role in the extensive communication networks of hormones and gene expression, remain an area of intense research. Orchestrating ...
Takahashi Toshiaki T National Children's Research Centre, Our Lady's Children's Hospital, Crumlin, Dublin 12, - - 2014
Pleuroperitoneal folds (PPFs) represent the only source of muscle precursors cells (MPCs) in the primordial diaphragm. However, the exact pathogenesis of malformed PPFs and congenital diaphragmatic hernia (CDH) remains unclear. The muscle-specific transcription factor myogenin plays a key role during development and muscularization of the fetal diaphragm. Although myogenin knockout ...
Protopopova Marina V MV Siberian Institute of Plant Physiology and Biochemistry, Siberian Branch Russian Academy of Sciences, Lermontov str., 132, Irkutsk, Russia, 664033, - - 2014
The species-rich, endemic amphipod fauna of Lake Baikal does not overlap with the common Palearctic fauna; however, the underlying mechanisms for this are poorly understood. Considering that Palearctic lakes have a higher relative input of natural organic compounds with a dominance of humic substances (HSs) than Lake Baikal, we addressed ...
Peng Ting - - 2014
BackgroundThe inferior spikelets are defined to be those at portions where the grains receive less photosynthetic products during the seed development. The typical inferior spikelets are physically located on the proximal secondary branches in a rice panicle and traditionally characterized by a later flowering time and a slower grain-filling rate, ...
Malsch Philipp P Department of Physiology and Medical Physics, Division of Physiology, Medical University of Innsbruck, A-6020 Innsbruck, - - 2014
Glycoprotein 130 (gp130) is the signal transducing receptor subunit for cytokines of the interleukin-6 (IL-6) family, and it is expressed in a multitude of cell types of the immune and nervous system. IL-6-like cytokines are not only key regulators of innate immunity and inflammation but are also essential factors for ...
Whan Alex A CSIRO Food Futures National Research Flagship, GPO Box 1600, Canberra ACT 2601 - - 2014
Wheat starch degradation requires the synergistic action of different amylolytic enzymes. Our spatio-temporal study of wheat α-amylases throughout grain development shows that AMY3 is the most abundant isoform compared with the other known α-amylases. Endosperm-specific over-expression of AMY3 resulted in an increase of total α-amylase activity in harvested grains. Unexpectedly, ...
Gaspar Imre I European Molecular Biology Laboratory, 69117 Heidelberg, - - 2014
Communication usually applies feedback loop-based filters and amplifiers to ensure undistorted delivery of messages. Such an amplifier acts during Drosophila melanogaster midoogenesis, when oskar messenger ribonucleic acid (mRNA) anchoring depends on its own locally translated protein product. We find that the motor regulator Klar β mediates a gain-control process that ...
Stephens Amanda N AN Monash University Accident Research Centre, Melbourne, Australia. Electronic address: - - 2014
The present study developed a revised version of the driving anger expression inventory (25-items) and a short (15-item) version using data from 551 drivers. Split half factor analyses on both versions confirmed the original four factors; personal physical aggressive expression, use of a vehicle to express anger, verbal aggressive expression ...
Korhan Peyda P From the Department of Medical Biology, Dokuz Eylul University Medical School, 35340, Inciralti-Izmir, - - 2014
c-Met receptor tyrosine kinase has been regarded as a promising therapeutic target for hepatocellular carcinoma (HCC). Recently, microRNAs (miRNAs) have been shown as a novel mechanism to control c-Met expression in cancer. In this study, we investigate the potential contribution of miR-181a-5p dysregulation to the biology of c-Met overexpression in ...
Settembre Carmine C Dulbecco Telethon Institute, Via Pietro Castellino 111, 80131, Naples, Italy; Telethon Institute of Genetics and Medicine (TIGEM), Via Pietro Castellino 111, 80131, Naples, Italy; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA; Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX, USA; Medical Genetics, Department of Translational and Medical Science, Federico II University, Via Pansini 5, 80131 Naples, Italy. Electronic address: - - 2014
Autophagy is a catabolic pathway that has a fundamental role in the adaptation to fasting and primarily relies on the activity of the endolysosomal system, to which the autophagosome targets substrates for degradation. Recent studies have revealed that the lysosomal-autophagic pathway plays an important part in the early steps of ...
Zhang Hong-Mei HM Key Laboratory of Freshwater Aquatic Genetic Resources, Shanghai Ocean University, Ministry of Agriculture, Shanghai 201306, - - 2014
Tropomyosin (TM) plays a critical role in skeletal and cardiac muscle development and function. To assess the functional significance of α-TM in Japanese flounder (Paralichthys olivaceus) development and metamorphosis, cDNA from Japanese flounder was cloned and α-TM mRNA measured during development and metamorphosis. The full-length cDNA is 1 191 bp, ...
Chng You R YR Department of Biological Sciences, National University of Singapore, Kent Ridge, Singapore, 117543, Republic of - - 2014
Argininosuccinate synthase (Ass) and argininosuccinate lyase (Asl) are involved in arginine synthesis for various purposes. The complete cDNA coding sequences of ass and asl from the liver of Protopterus annectens consisted of 1,296 and 1,398 bp, respectively. Phylogenetic analyses revealed that the deduced Ass and Asl of P. annectens had close ...
Lin Ke K Department of Haematology, Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool, UK; Department of Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool, - - 2014
This study was conducted to investigate the possibility that TP53 mRNA is variably expressed in chronic lymphocytic leukaemia (CLL) and that under-expression is associated with TP53 dysfunction and adverse outcome. Although TP53 mRNA levels did indeed vary among the 104 CLL samples examined, this variability resulted primarily from over-expression of ...
Desgeorges Marine Maud MM Laboratoire de Physiologie de l'Exercice EA 4338, Université de Lyon, Université Jean Monnet, Saint Etienne, - - 2014
In skeletal muscle, autophagy is activated in multiple physiological and pathological conditions, notably through the transcriptional regulation of autophagy-related genes by FoxO3. However, recent evidence suggests that autophagy could be also regulated by post-transcriptional mechanisms. The purpose of the study was therefore to determine the temporal regulation of transcriptional and ...
Duan Yujing Y Key Laboratory of Animal Physiology and Biochemistry, Ministry of Agriculture, Nanjing Agricultural University, Nanjing 210095, - - 2014
Chronic endogenous glucocorticoid (GC) excess in mammals is associated with metabolic dysfunction and dyslipidemia that is characterized by increased plasma triglyceride and total cholesterol (Tch) levels. However, the effects of chronic GC administration on cholesterol metabolism, particularly in muscle tissues of broiler chickens, are unknown. In this study, broiler chickens ...
Chen Wei W State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-Sen University, Guangzhou, - - 2014
Seasonally changing environmental conditions perceived by insect brains can be converted into hormonal signals that prompt insects to make a decision to develop or enter developmental arrest (diapause). Diapause is a complex physiological response, and many signaling pathways may participate in its regulation. However, little is known about these regulatory ...
Hamamura Kazunori K Department of Biomedical Engineering, Indiana University Purdue University Indianapolis, Indianapolis, IN 46202 - - 2014
Wnt signaling plays a major role in bone homeostasis and mechanotransduction, but its role and regulatory mechanism in osteoclast development are not fully understood. Through genome-wide in silico analysis, we examined Wnt3a-driven regulation of osteoclast development. Mouse bone marrow-derived cells were incubated with RANKL in the presence and absence of ...
Bonet F F University of Jaen, Biología Experimental, Jaen, - - 2014
Valve development is a multistep process involving the activation of the cardiac endothelium, an epithelial-mesenchymal transition (EMT) and the progressive lining and differentiation of distinct mesenchymal cell types into the fibrosa and spongiosa layers. Several pathways such as Notch/delta, Tbf-beta and/or Vegf signalling have been involved in a crucial steps ...
Kotsopoulos J J 1] Familial Breast Cancer Research Unit, Women's College Research Institute, Toronto, Ontario, M5G 1N8 Canada [2] Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, M5T 3M7 - - 2014
Background:Haploinsufficiency may contribute to the development of breast cancer among women with a BRCA1 mutation. Thus, interventions that enhance BRCA1 expression may represent avenues for prevention. Studies have shown that 3,3'-diindolylmethane (DIM) can upregulate BRCA1 expression in breast cancer cells. This has yet to be demonstrated in vivo.Methods:We conducted a ...
Farizano Juan V JV Instituto Superior de Investigaciones Biológicas, CONICET-UNT, - - 2014
Dps, the most abundant protein during stationary growth phase, in Salmonella enterica is required for resistance to reactive oxygen species produced by the host during infection. It has been reported that in Salmonella the dps expression is controlled by RpoS and Fur proteins. However, regulation and function of Dps remains ...
Pan Peipei P School of Life Sciences, University of Nevada, Las Vegas, 4505 Maryland Parkway, Las Vegas, NV 89154, - - 2014
Presumably to conserve energy, many mammals enter into hibernation during the winter. Homeostatic processes such as transcription and translation are virtually arrested. To further elucidate transcriptional regulation during hibernation, we studied the transcription factor p53. Here, we demonstrate that changes in liver mRNA and protein concentrations of known regulators of ...
Marsch-Martínez Nayelli N Departamento de Biotecnología y Bioquímica, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV-IPN), Irapuato, Gto, - - 2014
Fruits are complex plant structures that nurture seeds and facilitate their dispersal. The Arabidopsis fruit is termed silique. It develops from the gynoecium, which has a stigma, a style, an ovary containing the ovules, and a gynophore. Externally, the ovary consists of two valves, and their margins lay adjacent to ...
Wang Renhou R Section of Cell and Developmental Biology and Howard Hughes Medical Institute, UCSD, La Jolla, CA 92093, United - - 2014
Auxin is a versatile plant hormone that plays an essential role in most aspects of plant growth and development. Auxin regulates various growth processes by modulating gene transcription through a SCF(TIR1/AFB)-Aux/IAA-ARF nuclear signaling module. Recent work has generated clues as to how multiple layers of regulation of the auxin signaling ...
Gust Kurt A - - 2014
Corals represent symbiotic meta-organisms that require harmonization among the coral animal, photosynthetic zooxanthellae and associated microbes to survive environmental stresses. We investigated integrated-responses among coral and zooxanthellae in the scleractinian coral Acropora formosa in response to an emerging marine pollutant, the munitions constituent, 1,3,5-trinitro-1,3,5 triazine (RDX; 5 day exposures to ...
McGrann Graham Rd GR Department of Crop Genetics, John Innes Centre, Norwich Research Park, Norwich, NR4 7UH, - - 2014
NAC proteins are plant transcription factors that are involved in tolerance of abiotic and biotic stress as well as many developmental processes. Stress-responsive NAC 1 (SNAC1) transcription factor is involved in drought tolerance in barley and rice but it was not previously known to have a role in disease resistance. ...
Preus-Olsen Gunnhild G Department of Biology, Norwegian University of Science and Technology (NTNU), 7491 Trondheim, - - 2014
In the aquatic environments, the predicted changes in water temperature, pO2 and pCO2 could result in hypercapnic and hypoxic conditions for aquatic animals. These conditions are thought to affect several basic cellular and physiological mechanisms. Yet, possible adverse effects of elevated CO2 (hypercapnia) on teleost fish, as well as combined ...
Ling Lin L Faculty of Life Sciences, Northwestern Polytechnical University, Xi'an 710072, China; Key Laboratory of Insect Developmental and Evolutionary Biology, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032,China; University of Chinese Academy of Sciences, Beijing 100049, - - 2014
MicroRNAs (miRNAs) are a class of endogenous, non-coding, regulatory RNA molecules that post-transcriptionally regulate gene expression by binding to the 3'UTRs of mRNA targets and thus cause their degradation or translational inhibition. In insects, important roles of miRNAs in various biological processes have been demonstrated in Drosophila melanogaster. However, biological ...
Pateras Ioannis I National and Kapodistrian University of Athens, Medical School, First Department of Pathology , Athens , - - 2014
Introduction: NF-κB is a protein complex acting as a primary transcription factor and fast messenger to harmful cellular stimuli, including inflammation. Carotid atherosclerosis is an inflammatory process leading to atheroma formation and ultimately complicating the patient's condition. This review aims to critically summarize the role of NF-κB in atheroma formation ...
Meehl Michael A MA GlycoFi, Biologics Research, Merck & Co., Inc., 16 Cavendish Court, Lebanon, NH 03766, - - 2014
The selection of an expression platform for recombinant biopharmaceuticals is often centered upon suitable product titers and critical quality attributes, including post-translational modifications. Although notable differences between microbial, yeast, plant, and mammalian host systems exist, recent advances have greatly mitigated any inherent liabilities of yeasts. Yeast expression platforms are important ...
Florian Alexandra A Max-Planck-Institut für Molekulare Pflanzenphysiologie, Am Mühlenberg 1, 14476, Potsdam-Golm, - - 2014
As sessile organisms plants are subject to a multitude of environmental variations including several which directly affect their interaction with the atmosphere. Given the indiscriminant nature of Rubisco the relative rates of photosynthesis and photorespiration are known to be responsive to changes in gas composition. However, as yet comprehensive profiling ...
Pandey Ghanshyam N GN Department of Psychiatry, University of Illinois at Chicago, Chicago, IL, - - 2014
There is both direct and indirect evidence suggesting abnormalities of glycogen synthase kinase (GSK)-3β and β-catenin, two important components of the Wingless-type (Wnt) signaling pathway, in the pathophysiology of bipolar illness and possibly schizophrenia (SZ). In order to further clarify the role of the Wnt signaling pathway in the pathophysiology ...
Hill Kathryn T KT Department of Psychological and Brain Sciences, University of Delaware, Newark DE - - 2014
Previous work with various animal models has demonstrated that alterations in the caregiving environment produce long-term changes in anxiety-related and social behaviors, as well as amygdala gene expression. We previously introduced a rodent model in which the timing and duration of exposure to maltreatment or nurturing care outside the home ...
Huang Haiyan H Department of Medicine, Division of Cardiology, College of Physicians and Surgeons of Columbia University, 622W 168th Street, New York, New York, - - 2014
Pathologic cardiac hypertrophy can lead to heart failure, but the mechanisms involved are poorly understood. SERCA2 is critical for normal cardiac calcium handling and function and SERCA2 mRNA and protein levels are reduced by cardiac hypertrophy. We hypothesized that Extracellular Signal-regulated Kinase (ERK) 1/2 activation during hypertrophy reduced SERCA2 transcription. ...
Zhao Xu-Yun XY Life Sciences Institute and Department of Cell & Developmental Biology, University of Michigan Medical Center, Ann Arbor, MI 48109, - - 2014
Brown and beige/brite fats generate heat via uncoupled respiration to defend against cold. The total mass and activity of thermogenic adipose tissues are also tightly linked to systemic energy and nutrient homeostasis. Despite originating from distinct progenitors, brown and beige adipocytes acquire remarkably similar molecular and metabolic characteristics during differentiation ...
Chen Wenbo W Department of Biology, Institute of Resources and Environment, Henan Polytechnic University, Jiaozuo, 454000, Henan, People's Republic of China, - - 2014
In the present study, a full-length cDNA encoding the insulin-like growth factor binding protein-2 (IGFBP-2) was cloned from the liver of goldfish (Carassius auratus) by rapid amplification of cDNA ends technique. The goldfish IGFBP-2 cDNA sequence was 1,513 bp long and had an open reading frame of 825 bp encoding a predicted ...
Dai Shengjie S College of Agronomy and Biotechnology, China Agriculture University, Beijing 100193, PR China. Electronic address: - - 2014
To investigate the contribution of abscisic acid (ABA) in pear 'Gold Nijisseiki' during fruit ripening and under dehydration stress, two cDNAs (PpNCED1 and PpNCED2) which encode 9-cis-epoxycarotenoid dioxygenase (NCED) (a key enzyme in ABA biosynthesis), two cDNAs (PpCYP707A1 and PpCYP707A2) which encode 8'-hydroxylase (a key enzyme in the oxidative catabolism ...
Gruber Steffen S Institute of Molecular Biotechnology, Graz University of Technology, NAWI Graz, Petersgasse 14, 8010 - - 2014
The Gram-negative β-proteobacterium Ralstonia eutropha H16 is primarily known for polyhydroxybutyrate (PHB) production and its ability to grow chemolithoautotrophically by using CO2 and H2 as sole carbon and energy sources. The majority of metabolic engineering and heterologous expression studies conducted so far rely on a small number of suitable expression ...
Fragkostefanakis Sotirios S Goethe University, Department of Biosciences, Molecular Cell Biology of Plants; Max-von-Laue-Str. 9, 60438 Frankfurt/Main, Germany; Goethe University, Cluster of Excellence Frankfurt; Max-von-Laue-Str. 9, 60438 Frankfurt/Main, Germany. - - 2014
Cell survival under high temperature conditions involves the activation of heat stress response (HSR), which in principle is highly conserved among different organisms, but shows remarkable complexity and unique features in plant systems. The transcriptional reprogramming at higher temperatures is controlled by the activity of the heat stress transcription factors ...
Jouandin Patrick P Université Nice Sophia Antipolis, Institut de Biologie Valrose, iBV, Nice 06100, France CNRS, Institut de Biologie Valrose, iBV, UMR 7277, Nice 06100, France INSERM, Institut de Biologie Valrose, iBV, U1091, Nice 06100, - - 2014
When exposed to nutrient challenge, organisms have to adapt their physiology in order to balance reproduction with adult fitness. In mammals, ovarian follicles enter a massive growth phase during which they become highly dependent on gonadotrophic factors and nutrients. Somatic tissues play a crucial role in integrating these signals, controlling ...
Rivers Elena R ER Department of Pediatrics, Children's Hospital, Medical University of South Carolina , Charleston, SC , USA - - 2014
Objective: Preeclampsia (PE) affects 2-8% of pregnancies worldwide and is a significant source of maternal and neonatal morbidity and mortality. However, the mechanisms underlying PE are poorly understood and major questions regarding etiology and risk factors remain to be addressed. Our objective was to examine whether abnormal expression of the ...
Yi Andy Xianliang AX The Swire Institute of Marine Science and School of Biological Sciences, The University of Hong Kong, Pokfulam, Hong Kong, - - 2014
Triphenyltin compounds (TPTs), as effective biocides for different industrial and agricultural purposes, have been detected in coastal marine environments worldwide, in particular in Asian countries. However, little is known about their toxicity to marine organisms. This study comprehensively investigated the molecular, individual and population responses of the marine copepod, Tigriopus ...
Takekata Hiroki H Graduate School of Science, Osaka City University, Osaka, Japan. Electronic address: - - 2014
Whether a clock that generates a circatidal rhythm shares the same elements as the circadian clock is not fully understood. The mangrove cricket, Apteronemobius asahinai, shows simultaneously two endogenous rhythms in its locomotor activity; the circatidal rhythm generates active and inactive phases, and the circadian rhythm modifies activity levels by ...
Neels Jaap G JG Institut National de la Santé et de la Recherche Médicale U 1065, Mediterranean Center of Molecular Medicine (C3M), Team "Adaptive Responses to Immuno-metabolic Dysregulations," Nice, France; and Faculty of Medicine, University of Nice Sophia-Antipolis, Nice, - - 2014
The peroxisome proliferator-activated receptors, PPARα, PPARβ, and PPARγ, are a family of transcription factors activated by a diversity of molecules including fatty acids and fatty acid metabolites. PPARs regulate the transcription of a large variety of genes implicated in metabolism, inflammation, proliferation, and differentiation in different cell types. These transcriptional ...
Deng Chao C State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, China. - - 2014
Bacillus thuringiensis differs from the closely related Bacillus cereus group species by its ability to produce crystalline inclusions. The production of these crystals mainly results from the expression of the cry genes, from the stability of their transcripts and from the synthesis, accumulation and crystallization of large amounts of insecticidal ...
Hu Jun-Tao JT Department of Entomology, College of Agriculture and Biotechnology, China Agricultural University, Beijing 100193, PR - - 2014
It is generally believed that widely distributed species differ in their thermal plasticity from narrowly distributed species, but how differences in thermal plasticity are regulated at the molecular level remains largely unknown. Here, we conducted a comparative study of two closely related invasive fruit fly species, Bactrocera correcta and Bactroceradorsalis, ...
Hackenberg Michael M Computational Genomics and Bioinformatics Group, Genetics Department, University of Granada, Granada, - - 2014
Drought is a major constraint to crop production, and microRNAs (miRNAs) play an important role in plant drought tolerance. Analysis of miRNAs and other classes of small RNAs (sRNAs) in barley grown under water and drought conditions reveals that drought selectively regulates expression of miRNAs and other classes of sRNAs. ...
Best Carol C Department of Biology University of Waterloo, 200 University Avenue, Waterloo, ON N2L 3G1, - - 2014
The antidepressant venlafaxine is detected at parts per billion levels in tertiary-treated municipal wastewater effluent. However, the impact of this serotonin-norepinephrine reuptake inhibitor (SNRI) on non-target aquatic animals is poorly understood. We tested the hypothesis that environmentally relevant levels of venlafaxine disrupt the highly conserved cortisol and glucose response to ...
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