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Wang Xian-Wei XW Shandong University, - - 2014
Some aquatic invertebrates such as shrimp, contain low albeit stable numbers of bacteria in the circulating hemolymph. The proliferation of this hemolymph microbiota in such nutrient-rich environment is tightly controlled in healthy animals, but the mechanisms responsible had remained elusive. In the present study, we report a C-type lectin (MjHeCL) ...
Mi Yiling Y Washington University Medical School in Saint Louis, United - - 2014
The rate at which glycoproteins are cleared from the circulation has a critical impact on their biologic activity in vivo. We have shown that clearance rates for glycoproteins such as luteinizing hormone (LH) that undergo regulated release into the circulation determines their potency. Two highly abundant, carbohydrate-specific, endocytic receptors, the ...
Unkles Shiela E SE Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology-Hans Knöll Institute (HKI), Beutenbergstrasse 11a, Jena 07745, Germany; School of Biology, Biomedical Sciences Research Complex, University of St. Andrews, St. Andrews, Fife, KY16 9ST, UK. Electronic address: - - 2014
Filamentous fungi have the capacity to produce a battery of natural products of often unknown function, synthesized by complex metabolic pathways. Unfortunately, most of these pathways appear silent, many in intractable organisms, and their products consequently unidentified. One basic challenge is the difficulty of expressing a biosynthesis pathway for a ...
Kido Shinsuke S Department of Molecular Nutrition, the University of Tokushima Graduate School, Tokushima, - - 2014
Itai-itai disease is thought to be the result of chronic cadmium (Cd) intoxication. Renal proximal tubules are a major target of Cd toxicity. The whole mechanism of the adverse effects of Cd remains unresolved, especially how renal damage is related to the development of bone lesions. Fibroblast growth factor 23 ...
Dangi Satyaveer Singh SS Division of Physiology & Climatology, Indian Veterinary Research Institute, Izatnagar, Bareilly, Uttar Pradesh, 243122, - - 2014
Six, nonpregnant, Barbari goats aged 4-5 years were selected for the study. For the first 6 days, the animals were kept in psychrometric chamber at thermoneutral temperature for 6 h each day to make them acclimated to climatic chamber. On the 7th day, the animals were exposed to 41 °C temperature for 3 h and ...
Lu Huafei H Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education of China, Peking University, 38 Xueyuan Road, Beijing, 100191, - - 2014
Islet 1 (ISL1), a marker of second heart field progenitors, plays a crucial role in cardiomyocyte differentiation and proliferation. However, little is known about transcriptional regulating mechanisms on Isl1 gene expression. Recent studies have demonstrated that Wnt/β-catenin signaling regulates Isl1 expression during heart development. However, the detailed mechanisms still remain ...
Liu Zhifeng Z Key Laboratory of Functional Proteomics of Guangdong Province, Department of Pathophysiology, Southern Medical University, Guangzhou, 510515, China; Department of Intensive Care Unit, General Hospital of Guangzhou Military Command, Guangzhou, 510010, - - 2014
Inducible nitric oxide synthase (iNOS) plays a central role in tissue damage during endotoxic shock. However, the underlying mechanisms that control transcription of iNOS are not completely defined. A screening strategy with DNA pull-down technology and 2D-DIGE analysis was applied to identify regulators interacting with iNOS promoter. We found fourteen ...
Planey Sonia Lobo - - 2014
Transcription factors (TFs) orchestrate multiple cellular processes through tight regulation via post-translational modifications (PTMs). Thus, decoding the combinations of PTMs should provide critical layer of information that can be integrated into highly specific cellular outputs to reveal a network of genes and their target-specific regulation. Protein modifications play a decisive ...
Liu Chen C MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing University, 12 Xuefu Rd, Pukou District, Nanjing, Jiangsu 210061, - - 2014
Hedgehog (Hh) signaling plays vital roles in animal development and tissue homeostasis, and its misregulation causes congenital diseases and several types of cancer. Suppressor of Fused (Su(fu)) is a conserved inhibitory component of the Hh signaling pathway, but how it is regulated remains poorly understood. Here we demonstrate that in ...
Kampinga Harm H HH Department of Cell Biology, University Medical Center Groningen and University of Groningen, 9700 RB Groningen, the Netherlands. Electronic address: - - 2014
In this issue, Gray et al. (2014) elegantly demonstrate how cells utilize an oxidation-regulated pathway that depletes cellular ATP, lowers proteostatic burden, and leads to accumulation of prebiotic, inorganic polyphosphates with chaperone-like activity for stress protection.
Rasmussen Susanne S AgResearch Grasslands Research Centre, P.B. 11008, Palmerston North, New Zealand. Electronic address: - - 2014
Lolium perenne cultivars with elevated levels of fructans in leaf blades (high sugar-content grasses) have been developed to improve animal nutrition and reduce adverse environmental impacts of pastoral agricultural systems. Expression of the high sugar trait can vary substantially depending on genotype×environment (G×E) interactions. We grew three potential high sugar-content ...
Borirak Orawan O Swammerdam Institute for Life Sciences, University of Amsterdam, The - - 2014
Here we report on the use of the chemostat as an optimal device to create time-invariant conditions that allow accurate sampling for various omics assays in Escherichia coli, in combination with recording of the dynamics of the physiological transition in the organism under study that accompany the initiation of glucose ...
Ryall Karen A KA Department of Biomedical Engineering, University of - - 2014
Cardiac hypertrophy is controlled by a highly connected signaling network with many effectors of cardiac myocyte size. Quantification of the contribution of individual pathways to specific changes in shape and transcript abundance is needed to better understand hypertrophy signaling and to improve heart failure therapies. We stimulated cardiac myocytes with ...
Kaminski T T Department of Animal Physiology, University of Warmia and Mazury in Olsztyn, Olsztyn, - - 2014
Adiponectin is a hormonal link between obesity and reproduction, and its actions are mediated by two types of receptors: adiponectin receptor 1 (AdipoR1) and adiponectin receptor 2 (AdipoR2). This study compares the expression levels of adiponectin and adiponectin receptor mRNAs and proteins in selected areas of the porcine hypothalamus responsible ...
Chandran Divya D M S Swaminathan Research Foundation, 3rd Cross Road, Institutional Area, Taramani, Chennai, 600113 - - 2014
Jatropha curcas has been widely studied at the molecular level due to its potential as an alternative source of fuel. Many of the reports till date on this plant have focussed mainly on genes contributing to the accumulation of oil in its seeds. A suppression subtractive hybridization strategy was employed ...
Acharjee Shaona S Departments of Medicine, University of Alberta, Edmonton, Canada; Department of Physiology and Pharmacology and Hotchkiss Brain Institute, University of Calgary, Bangkok, - - 2014
Neuropsychiatric disorders during HIV/AIDS are common although the contribution of HIV-1 infection within the brain, and in particular individual HIV-1 proteins, to the development of these brain disorders is unknown. Herein, an in vivo transgenic mouse model was generated in which the HIV-1 Nef protein was expressed in microglia cells, ...
Personat José-María - - 2014
We have previously reported that the seed-specific overexpression of sunflower (Helianthus annuus L.) Heat Shock Factor A9 (HaHSFA9) enhanced seed longevity in transgenic tobacco (Nicotiana tabacum L.). In addition, the overexpression of HaHSFA9 in vegetative organs conferred tolerance to drastic levels of dehydration and oxidative stress. Here we found that ...
Pérez-Pantoja Danilo D Systems Biology Program. Centro Nacional de Biotecnología CSIC, Darwin 3, 28049 Madrid, - - 2014
Pseudomonas putida mt-2 encompasses two alternative and potentially conflicting routes for benzoate metabolism, one meta pathway encoded by xyl genes of the pWW0 plasmid and mastered by the Pm promoter and XylS, and one chromosomally-encoded ortho pathway initiated by Pben and the BenR protein. Any cross-activation of Pben promoter by ...
Kang Chen C Department of Endocrinology, PLA General Hospital, Beijing, - - 2014
Aim:To investigate the effect of telmisartan on the lipometabolisms and the proinflammatory factors secreted from 3T3-L1 adipocytes and to explore the possible mechanisms. Telmisartan was applied to interfere with mature 3T3-L1 adipocytes. The culture's free fatty acids, interleukin 6 (IL-6) and tumor necrosis factor α (TNFα) were evaluated. Oil Red ...
Orozco Aurea A Instituto de Neurobiología, Universidad Nacional Autónoma de México (UNAM), Boulevard Juriquilla 3001, Querétaro, Qro. 76230, Mexico. Electronic address: - - 2014
Thyroid hormone (TH) actions are mediated by triiodothyronine (T3), which acts by binding to the TH receptors (TRs). Since TH exert pleiotropic effects, interest has grown in identifying other possible bioactive thyronines that could explain their diversity of functions. Accordingly, 3,5-diiodothyronine (T2) has been shown to be bioactive. In mammals, ...
Chen Chien-Ming CM Department of Biological Sciences, National Sun Yat-Sen University, Kaohsiung, - - 2014
Mammalian oligosaccharyltransferase complex subunit OSTC/DC2 protein has recently been shown to be a new subunit of the oligosaccharyltransferase; however, its physiological role is still unclear. Here, we report the expression pattern of OSTC/DC2 protein in the context of heat shock stress. Its upregulation was detected both in cells treated with ...
Endo Shinya S Drug Metabolism and Toxicology, Faculty of Pharmaceutical Sciences, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan. Electronic address: - - 2014
MicroRNAs (miRNA) form a class of small non-coding RNA molecules that negatively regulate gene expression. Most cellular pathways are modulated by miRNAs. However, the pathophysiological role of miRNAs during drug-induced liver injury (DILI) remains largely unknown. In this study, the possible involvement of miRNAs in DILI caused by the hepatotoxic ...
Li Junyan J Research School of Biology, Australian National University, Acton, Australian Capital Territory, - - 2014
Plant microRNAs (miRNAs) are critical regulators of gene expression, however little attention has been given to the principles governing miRNA silencing efficacy. Here, we utilize the highly conserved Arabidopsis miR159-MYB33/MYB65 regulatory module to explore these principles. Firstly, we show that perfect central complementarity is not required for strong silencing. Artificial ...
Romilly Cédric C Architecture et Réactivité de l'ARN, Université de Strasbourg, CNRS, IBMC, Strasbourg, - - 2014
Staphylococcus aureus produces a high number of RNAs for which the functions are poorly understood. Several non-coding RNAs carry a C-rich sequence suggesting that they regulate mRNAs at the post-transcriptional level. We demonstrate that the Sigma B-dependent RsaA RNA represses the synthesis of the global transcriptional regulator MgrA by forming ...
Wernet Mathias F MF Center for Developmental Genetics, Department of Biology, New York University, New York, New York, United States of America; Department of Neurobiology, Stanford University, Stanford, California, United States of - - 2014
The elbow/no ocelli (elb/noc) complex of Drosophila melanogaster encodes two paralogs of the evolutionarily conserved NET family of zinc finger proteins. These transcriptional repressors share a conserved domain structure, including a single atypical C2H2 zinc finger. In flies, Elb and Noc are important for the development of legs, eyes and ...
Adhi Susanto Sony S Justus-Liebig-University of Gießen, Department of Rheumatology and Clinical Immunology, Kerckhoff-Klinik, Bad Nauheim, - - 2014
In mammals, tissue or organ damage often results in fibrotic scar formation, which in turn may impair proper organ function. Many urodele amphibians are capable of regenerating different tissues including lenses, heart, and spinal cord or even entire body parts like limbs or tails without any functional impairment. We previously ...
Lin Huang-Quan HQ School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, SAR, China, - - 2014
Mice deficient in acetylcholinesterase (AChE; EC3.1.1.7) exhibited significant phenotypical and biochemical changes when compared with wild-type littermates. They showed a delay of growth in weight and size, immature external ears, and persistent body tremor, and they circled when walking. The molecular mechanisms underlying these changes have not been investigated yet. ...
Woods Ian G IG Department of Biology, Ithaca College, Ithaca, New York 14850, and Department of Molecular and Cellular Biology and Center for Brain Science, Harvard University, Cambridge, Massachusetts - - 2014
Animals modulate their arousal state to ensure that their sensory responsiveness and locomotor activity match environmental demands. Neuropeptides can regulate arousal, but studies of their roles in vertebrates have been constrained by the vast array of neuropeptides and their pleiotropic effects. To overcome these limitations, we systematically dissected the neuropeptidergic ...
Ming Guang-Feng GF Institute of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, Central South University, Changsha 410078, Hunan, China; Department of critical care medicine, Xiangya Hospital, Central South University, Changsha 410008, Hunan, - - 2014
JAZF1 is a newly identified gene with unknown functions. A recent genome-wide association study showed that JAZF1 is associated with type 2 diabetes and is highly expressed in liver and adipose tissue. Studies have demonstrated that JAZF1 is the co-repressor for nuclear orphan receptor TAK1, whereas most nuclear orphan receptor ...
Hu Yong-Hua - - 2014
Hfq is an RNA-binding protein that plays an important role in many cellular processes. In this study, we examined the biological effect of the Hfq of Edwardsiella tarda, a severe fish pathogen with a broad host range that includes humans. To facilitate the study, a markerless hfq in-frame deletion mutant, ...
Malakar Pushkar P Department of Bioscience and Bioengineering, Indian Institute of Technology Bombay, Powai, Mumbai, 400076, Maharashtra, India, - - 2014
Expression of unnecessary proteins is known to reduce the growth rate of Escherichia coli. This reduction in growth rate, due to the diversion of cellular resources from making essential proteins, is called cost. Cellular resources depend upon the macromolecular content of the cell. Cost phenomenon lies in the process of ...
Chervona Yana Y NYU Langone Medical - - 2014
Cellular response to changes in oxygen tension during normal development or pathological processes is, in part, regulated by hypoxia-inducible factor (HIF), an oxygen sensitive transcription factor. HIF activity is primarily controlled through post-translational modifications, and stabilization of HIF-1α; and HIF-2α; proteins, and is regulated by a number of cellular pathways ...
Krishnan Karthik - - 2014
The unfolded protein response (UPR) is a network of intracellular signaling pathways that supports the ability of the secretory pathway to maintain a balance between the load of proteins entering the endoplasmic reticulum (ER) and the protein folding capacity of the ER lumen. Current evidence indicates that several pathogenic fungi ...
Gao Yuan Y Molecular Cancer Research; Center for Molecular Medicine; University Medical Centre Utrecht; Utrecht, The Netherlands ; Department of Biochemistry and Molecular Biology; School of Medicine; Soochow University; Suzhou, PR - - 2014
Adipogenesis is regulated by a complex interplay between transcription factors, in concert with-among others-transcriptional cofactors, signaling cascades and miRNAs. Several studies have implicated the transcriptional cofactor and acetyltransferase Tip60 in PPARγ signaling and adipocyte differentiation. Since Tip60 protein levels, but not mRNA levels, are upregulated during adipogenesis, and since Tip60 ...
Sundaram Arunkumar A Faculty of Life Sciences, The University of Manchester, Manchester M13 9PT, United - - 2014
Candida albicans is a major fungal pathogen that responds to various environmental cues as part of its infection mechanism. We show here that the expression of C. albicans GCN4, which encodes a transcription factor that regulates morphogenetic and metabolic responses, is translationally regulated in response to amino acid starvation induced ...
Stenina-Adognravi Olga O Department of Molecular Cardiology Cleveland Clinic 9500 Euclid Ave NB50 Cleveland, OH 44195. Electronic address: - - 2014
Increasing evidence suggests critical functions of thrombospondins (TSPs) in a variety of physiological and pathological processes. With the growing understanding of the importance of these matricellular proteins, the need to understand the mechanisms of regulation of their expression and potential approaches to modulate their levels is also increasing. The regulation ...
Lin Chien-Ru CR Graduate Institute of Life Sciences, National Defense Medical Center, Neihu, Taipei 114, Taiwan, Republic of - - 2014
In plants, source-sink communication plays a pivotal role in crop productivity, yet the underlying regulatory mechanisms are largely unknown. The SnRK1A protein kinase and transcription factor MYBS1 regulate the sugar starvation signaling pathway during seedling growth in cereals. Here, we identified plant-specific SnRK1A-interacting negative regulators (SKINs). SKINs antagonize the function ...
Wurtmann Elisabeth J EJ Institute for Systems Biology, Seattle, WA, 98109, - - 2014
It is known that environmental context influences the degree of regulation at the transcriptional and post-transcriptional levels. However, the principles governing the differential usage and interplay of regulation at these two levels are not clear. Here, we show that the integration of transcriptional and post-transcriptional regulatory mechanisms in a characteristic ...
Hichri Imène I 1 Universite catholique de - - 2014
The zinc Fingers superfamily includes transcription factors regulating multiple aspects of plant development, and more recently abiotic stress tolerance. Tomato (Solanum lycopersicum L.) SlZF2 is a C2H2-type zinc finger transcription factor bearing an EAR repression domain, and binding to the ACGTCAGTG sequence containing two AGT core motifs. SlZF2 is ubiquitously ...
Siegel T Nicolai - - 2014
Advances in high-throughput sequencing have led to the discovery of widespread transcription of natural antisense transcripts (NATs) in a large number of organisms, where these transcripts have been shown to play important roles in the regulation of gene expression. Likewise, the existence of NATs has been observed in Plasmodium but ...
Holmes Michael V MV 1Division of Transplant Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA & Genetic Epidemiology Group, Institute of Cardiovascular Science, University College London, London, United - - 2014
-Secretory phospholipase A2 (sPLA2) enzymes are considered to play a role in atherosclerosis. sPLA2 activity encompasses several sPLA2 isoenzymes, including sPLA2-V. While observational studies show strong association between elevated sPLA2 activity and CHD, no assay to measure sPLA2-V levels exists and the only evidence linking the sPLA2-V isoform to atherosclerosis ...
Qian X X Research Institution of Subtropical Foresty, Chinese Academy of Forestry, Fuyang, Zhejiang Province, - - 2014
The flower developmental process, which is crucial to the whole lifecycle of higher plants, is influenced by both environmental and endogenous factors. The genus Oncidium is commercially important for cut flower and houseplant industry and is ideal for flower development studies. Using cDNA-amplified restriction fragment length polymorphism analysis, we profiled ...
Yang Lu L State Key Laboratory of Biocontrol, Institute of Aquatic Economic Animals and Guangdong Provincial Key Laboratory for Aquatic Economic Animals, School of Life Sciences, Sun Yat-Sen University, Guangzhou 510275, P R - - 2014
Neuropeptide B (NPB) regulates food intake, energy homeostasis and hormone secretion in mammals via two G-protein coupled receptors, termed as GPR 7 and GPR 8. However, there is no study that reports the function of NPB in teleosts. In this study, the full-length cDNA of prepro-NPB with the size of ...
Kennedy Lisa M LM Columbia - - 2014
Endogenous short RNAs and the conserved PHD zinc finger protein ZFP-1/AF10 regulate overlapping sets of genes in Caenorhabditis elegans, which suggests that they control common biological pathways. We have shown recently that the RNAi factor RDE-4 and ZFP-1 negatively modulate transcription of the insulin/PI3 signaling-dependent kinase PDK-1 to promote C. ...
Wang Kun K Institute of Zoology, Chinese Academy of - - 2014
Sustained cardiac hypertrophy is often accompanied by maladaptive cardiac remodeling leading to decreased compliance and increased risk for heart failure. Maladaptive hypertrophy is considered to be a therapeutic target for heart failure. microRNAs and Long non-coding RNAs (LncRNAs) have various biological functions, and have been extensively investigated throughout the past ...
Kielbowicz-Matuk Agnieszka A Institute of Plant Genetics, Polish Academy of Sciences, Strzeszyńska 34, 60-479 Poznań, - - 2014
Background and AimsDouble B-box zinc finger (DBB) proteins are recently identified plant transcription regulators that participate in the response to sodium chloride-induced stress in arabidopsis plants. Little is known regarding their subcellular localization and expression patterns, particularly in relation to other osmotic constraints and the day/night cycle. This study investigated ...
Helbling Jean-Christophe JC INRA, Nutrition and Integrative Neurobiology, Bordeaux, France; Univ Bordeaux, Nutrition & Integrative Neurobiology, Bordeaux, - - 2014
The NR4A nuclear receptors subgroup, comprising Nur77 (NR4A1), Nurr1 (NR4A2), and Nor1 (NR4A3), are orphan receptors induced by a variety of signals, including stress. These receptors are described as early response genes and in vitro studies have shown that they take part in regulation of the hypothalamic-pituitary-adrenal (HPA) axis, the ...
Khabar Khalid S A KS Department of BioMolecular Research, King Faisal Specialist Hospital and Research Centre , Riyadh, Saudi Arabia - - 2014
Post-transcriptional control of cytokine gene expression is essential for rapid and transient response to stimuli and external stress. In health, post-transcriptional control is exerted by a number of trans-acting RNA-binding proteins and cis-acting sequence elements. These elements exist largely in the 3' untranslated region and comprise microRNA targets and notably ...
Shan Wei W State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources/Guangdong Key Laboratory for Postharvest Science, College of Horticultural Science, South China Agricultural University, Guangzhou 510642, - - 2014
Our previous studies have indicated that the banana ripening-induced MaNAC1, a NAC (NAM, ATAF1/2 and CUC2) transcription factor (TF) gene, is regulated by ethylene during fruit ripening, and propylene, a functional ethylene analog, induces cold-tolerance of banana fruit. However, the involvement of MaNAC1 in propylene-induced cold-tolerance of banana fruit is ...
Chen Siyu S From the Jiangsu Key Laboratory for Molecular and Medical Biotechnology and College of Life Sciences, Nanjing Normal University, Nanjing, Jiangsu 210023, - - 2014
Vanin-1 (VNN1) is a liver-enriched oxidative stress sensor that has been implicated in the regulation of multiple metabolic pathways. Clinical investigations indicated that the levels of VNN1 were increased in the urine and blood of diabetic patients, but the physiological significance of this phenomenon remains unknown. In this study, we ...
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