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Li Yingzhi Y Department of Neurology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, P.R. - - 2014
FRMD7 mutations are associated with X-linked idiopathic congenital nystagmus (ICN); however, the underlying mechanisms whereby mutations of FRMD7 lead to ICN remain unclear. In a previous study, the first FRMD7 splice variant (FRMD7-S) was cloned and identified, and FRMD7-S was hypothesized to play a significant role in neuronal differentiation and ...
Kasuya Hikaru H Faculty of Pharmaceutical Sciences, Toho University, Funabashi, Chiba, 274-8510, - - 2014
Essential oils are mainly administered by inhalation. Administration by inhalation is considered to occur through two pathways, neurological transfer and pharmacological transfer. However, the relationship between the two routes is not clear. To clarify this relationship, we administered α-pinene, which has an anxiolytic-like effect, to mice. Emotional behavior and accumulation ...
Sun Xiaqin X State Key Laboratory of Biomembrane and Membrane Biotechnology, College of Life Sciences, PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing 100871, China; - - 2014
Axon pathology has been widely reported in Alzheimer's disease (AD) patients and AD mouse models. Herein we report that increased miR-342-5p down-regulates the expression of ankyrin G (AnkG), a protein known to play a critical role in establishing selective filtering machinery at the axon initial segment (AIS). Diminished AnkG expression ...
Seredick Steve S Institute of Neuroscience, 1254 University of Oregon, Eugene, OR 97403, - - 2014
A central problem in development is how fates of closely related cells are segregated. Lineally related motoneurons (MNs) and interneurons (INs) express many genes in common yet acquire distinct fates. For example, in mouse and chick Lhx3 plays a pivotal role in the development of both cell classes. Here, we ...
Grabenstatter Heidi L HL Department of Pediatrics, Section of Neurology, Translational Epilepsy Research Program, University of Colorado, AMC, Aurora, Colorado, - - 2014
Temporal lobe epilepsy (TLE) is frequently medically intractable and often progressive. Compromised inhibitory neurotransmission due to altered γ-aminobutyric acid (GABA)A receptor α4 subunit (GABAA Rα4) expression has been emphasized as a potential contributor to the initial development of epilepsy following a brain insult (primary epileptogenesis), but the regulation of GABAA ...
Wang Shukun S The State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China University of Chinese Academy of Sciences, Beijing, - - 2014
Astrocyte differentiation is essential for late embryonic brain development, and autophagy is active during this process. However, it is unknown whether and how autophagy regulates astrocyte differentiation. Here, we show that Atg5, which is necessary for autophagosome formation, regulates astrocyte differentiation. Atg5 deficiency represses the generation of astrocytes in vitro ...
Rajaram Kamya K Department of Biological Sciences, Vanderbilt University, Nashville, - - 2014
Background: Adult zebrafish spontaneously regenerate their retinas after damage. Although a number of genes and signaling pathways involved in regeneration have been identified, the exact mechanisms regulating various aspects of regeneration are unclear. microRNAs were examined for their potential roles in regulating zebrafish retinal regeneration. Results: To investigate the requirement ...
Cai MuDan - - 2014
Amyotrophic lateral sclerosis (ALS) is an adult onset disease that produces gradual motor neuron cell death in the spinal cord (SP). Recently, transactive response DNA-binding protein 43 kDa (TDP-43), a critical component of insoluble ubiquitinated inclusions, has received attention in the treatment of neurodegenerative disorders, including frontotemporal lobar degeneration (FTLD) ...
Mojsa B B 1] Institut de Génétique Moléculaire de Montpellier UMR 5535 CNRS, Montpellier 34293, France [2] Université Montpellier 2, Montpellier 34095, France [3] Université Montpellier 1, Montpellier 34967, - - 2014
Neuronal apoptosis induced by survival factor deprivation is strongly regulated at the transcriptional level. Notably, the nuclear factor of activated T cell (NFAT) transcription factors have an important role in the control of the survival/death fate of neurons. However, the mechanisms that regulate NFAT activity in response to apoptotic stimuli ...
Bolós Marta M Menzies Research Institute Tasmania, - - 2014
Amyloid-β precursor protein (APP) is well studied for its role in Alzheimers disease, although its normal function remains uncertain. It has been reported that APP stimulates the proliferation and neuronal differentiation of neural stem / progenitor cells (NSPCs). In this study, we examined the role of APP in NSPC differentiation. ...
Dean Benjamin J - - 2014
The conserved habenular nuclei function as a relay system connecting the forebrain with the brain stem. They play crucial roles in various cognitive behaviors by modulating cholinergic, dopaminergic and serotonergic activities. Despite the renewed interest in this conserved forebrain region because of its importance in regulating aversion and reward behaviors, ...
Bogdanovic Elena E Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, 2075 Bayview Ave, D704, Toronto, ON, Canada M4N 3M5. Electronic address: - - 2014
Isocitrate dehydrogenase 1 (IDH1) is an evolutionarily conserved enzyme that catalyzes the interconversion of isocitrate to α-ketoglutarate with the concomitant reduction of NADP(+) to NADPH. IDH1 has previously been shown to participate in lipid biosynthesis in various tissues such as the liver and adipose tissue. We examined the potential role ...
Brown Rse R Centre for Neuroendocrinology and Departments of Anatomy, University of Otago, Dunedin, New - - 2014
Hyperprolactinaemia is a major cause of infertility in both males and females, but the mechanism by which prolactin inhibits the reproductive axis is not clear. The aim of the present study was to test the hypothesis that elevated prolactin causes suppression of kisspeptin expression in the hypothalamus, resulting in reduced ...
Yeung Joanna J http://orcid.org/0000-0003-0551-5305 Department of Medical Genetics, Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada V5Z4H4 - - 2014
Math1 is the defining molecule of the cerebellar rhombic lip and Pax6 is downstream in the Math1 pathway. In the present study, we discover that Wntless (Wls) is a novel molecular marker of the cells in the interior face of the rhombic lip throughout normal mouse cerebellar development. Wls expression ...
Zhang Ji J Center of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, 210009, - - 2014
Ammonia is considered to be the main neurotoxin responsible for hepatic encephalopathy resulting from liver failure. Liver failure has been reported to alter expression and activity of P-glycoprotein (P-gp) and multidrug resistance-associated protein 2 (Mrp2) at the blood-brain barrier (BBB). The aim of this study was to investigate whether ammonia ...
He Lu L Department of Anatomy and Histology, School of Basic Medical Sciences, Tianjin Medical University, 22 Qixiangtai Road, Tianjin, 300070, - - 2014
Previous studies have suggested that progesterone may be involved in neuroprotection by preventing brain edema. In this study, we assessed the effects of progesterone on aquaporin-4 (AQP4) expression in an ischemia/reperfusion model of cultured rat astrocytes, and further explored the possible role of the protein kinase C (PKC) pathway in ...
Lu Kwok-Tung KT Department of Life Science, National Taiwan Normal University, Taipei, - - 2014
Traumatic brain injury (TBI) is one of the most prevalent causes of worldwide mortality and morbidity. We previously had evidenced that TBI induced Na-K-2Cl co-transporter (NKCC1) upregulation in hippocampus. Here, we aim to investigate the role of NKCC1 in TBI-induced neurogenesis and the detailed mechanisms. The TBI-associated alternations in the ...
Xu Niangui N Department of Neurology, The Second Xiangya Hospital of the Central South University, Changsha, China - - 2014
The possible roles played by growth arrest and DNA damage-inducible gene 34 (GADD34) in Alzheimer's disease (AD) are so far less understood. In this study, we found that GADD34 was increased in the brains of AD transgenic J20 mice. The deposition of β-amyloid (Aβ) peptide is the main component of ...
Hollins Sharon L - - 2014
MicroRNAs (miRNAs) play a pivotal role in coordinating messenger RNA (mRNA) transcription and stability in almost all known biological processes, including the development of the central nervous system. Despite our broad understanding of their involvement, we still have a very sparse understanding of specifically how miRNA contribute to the strict ...
Xu Da-Ping DP State Key Laboratory of Quality Research in Chinese Medicine and Institute of Chinese Medical Sciences, University of Macau, Avenue Padre Tomás Pereira S.J., Macao SAR, China; Department of Applied Biology and Chemical Technology, Institute of Modern Chinese Medicine, Hong Kong Polytechnic University, Hong Kong, - - 2014
The natural product tetramethylpyrazine (TMP) has a variety of biologic activities, including neuroprotection. Nitrones are powerful free radical scavengers. We have designed and synthesized a TMP derivative, TN-2, which is armed with two nitrone moieties. In this study, we investigated the neuroprotective effect of TN-2 against 6-hydroxydopamine (6-OHDA)-induced neurotoxicity in ...
Guo Weiwei - - 2014
BackgroundThe impact of miRNA differential expression on the auditory epithelium stem cell development in postnatal rats is not clear. The present study was designed to analyze miRNA expression in the organ of Corti of neonatal and adult rats.MethodsThe cochleae of newborn (P0) and adult (P30) Sprague-Dawley rats were dissected in ...
Laporta Jimena J Departments of Dairy - - 2014
Calcium homeostasis during lactation is critical for maternal and neonatal health. We previously showed that non-neuronal/peripheral serotonin (5-hydroxytryptamine, 5-HT) causes the lactating mammary gland to synthesize and secrete parathyroid hormone-related protein (PTHrP) in an acute fashion. Here, using a mouse model we found that genetic inactivation of tryptophan hydroxylase 1 ...
Lenihan Joan A JA School of Biochemistry and Cell Biology, University College Cork, Cork, - - 2014
LNX1 and LNX2 are E3 ubiquitin ligases that can interact with Numb - a key regulator of neurogenesis and neuronal differentiation. LNX1 can target Numb for proteasomal degradation, and Lnx mRNAs are prominently expressed in the nervous system, suggesting that LNX proteins play a role in neural development. This hypothesis ...
Wakuda Tomoyasu T Department of Psychiatry, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka 431-3192, - - 2014
Epidemiological studies suggest that perinatal complications, particularly hypoxia-related ones, increase the risk of schizophrenia. Recent genetic studies of the disorder have identified several putative susceptibility genes, some of which are known to be regulated by hypoxia. It can be postulated therefore that birth complications that cause hypoxia in the fetal ...
Dávila David D Department of Physiology and Medical Physics and RCSI Centre for the Study of Neurological Disorders (CSND), Royal College of Surgeons in Ireland, 123 St Stephen's Green, Dublin 2, Ireland. Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain. daviddav@ucm.es - - 2014
Neurons face a changeable microenvironment and therefore need mechanisms that allow rapid switch on/off of their cyto-protective and apoptosis-inducing signaling pathways. Cellular mechanisms which control apoptosis activation include the regulation of pro/anti-apoptotic mRNAs through their 3'-untranslated region (UTR). This region holds binding elements for RNA-binding proteins (RBPs) which can control ...
Toyoda Atsushi A United Graduate School of Agricultural Science, Tokyo University of Agriculture and Technology, Fuchu, Japan; College of Agriculture, Ibaraki University, Ibaraki, Japan; Ibaraki University Cooperation between Agriculture and Medical Science (IUCAM), Ibaraki, - - 2014
The hippocampus plays a key role in learning and emotional regulation. The hippocampus' function varies along its septotemporal axis, with the septal pole being more frequently involved in spatial learning and memory, and the temporal pole playing a greater role in emotional behaviors. In this study, we present findings aimed ...
Lue Lih-Fen LF Laboratory of Neuroregeneration, Banner Sun Health Research Institute, Sun City, Arizona, - - 2014
Triggering receptor expressed by myeloid cells 2 (TREM2), a member of immunoglobulin superfamily, has anti-inflammatory phagocytic function in myeloid cells. Several studies have shown that TREM2 gene variant rs75932628-T increased the risks for Alzheimer's disease (AD), Parkinson's disease, frontotemporal dementia, and amyotrophic lateral sclerosis. It has been suggested that the ...
Song Honghua H Key Laboratory of Neuroregeneration, Co-innovation Center of Neuroregeneration, Nantong University, 19 Qixiu Road, 226007, Nantong, People's Republic of - - 2014
The Wingless/Integrated (Wnt) signaling pathway plays important roles in central nervous system (CNS) development and regeneration, and β-catenin, the central component, has been considered in association with adult neurogenesis. To decipher its roles on spontaneous spinal cord regeneration, we cloned β-catenin from Gekko japonicus and examined its function in regenerating ...
Draganova Kalina K Cell and Developmental Biology Division, Institute of Anatomy, University of - - 2014
The fate of neural progenitor cells (NPC) is determined by a complex interplay of intrinsic programs and extrinsic signals, very few of which are known. β-catenin transduces extracellular Wnt signals, but also maintains adherens junctions integrity. Here, we identify for the first time the contribution of β-catenin transcriptional activity as ...
Zanotti-Fregonara Paolo P aUniversity of Bordeaux, CNRS, INCIA, UMR 5287, Talence bCEA, DSV, I2BM, SHFJ, Orsay cINSERM, CEA, University Paris sud, University Paris Descartes, Research Unit 1000 'NeuroImagery & Psychiatry', Orsay dCEA, DSV, I2BM, Neurospin, Gif-sur-Yvette, France eDepartment of Information Engineering, University of Padova, Padova, - - 2014
[C]Befloxatone is a highly specific, reversible, and selective radioligand for brain PET imaging of monoamine oxidase-A and can be quantified by a two-tissue compartment model (2TCM) and an arterial input function. The aims of the present study were the following: (a) to assess whether in-vivo protein concentration, as measured by ...
Koh Phil-Ok PO Department of Anatomy, College of Veterinary Medicine and Research Institute of Life Science, Gyeongsang National University, Jinju, South Korea. Electronic address: - - 2014
Estradiol has protective and reparative effects in neurodegenerative diseases. Hippocalcin is a neuronal calcium-sensor protein that acts as a calcium buffer to regulate the intracellular concentration of Ca(2+). This study was investigated to elucidate whether estradiol regulates hippocalcin expression in a focal cerebral ischemia model and glutamate-treated neuronal cells. An ...
Bagley Joshua A JA Neuroscience Graduate Program, University of California at San Francisco, San Francisco, California 94158, USA; Howard Hughes Medical Institute, Department of Physiology, Department of Biochemistry and Biophysics, University of California at San Francisco at San Francisco, California 94158, - - 2014
A complex array of genetic factors regulates neuronal dendrite morphology. Epigenetic regulation of gene expression represents a plausible mechanism to control pathways responsible for specific dendritic arbor shapes. By studying the Drosophila dendritic arborization (da) neurons, we discovered a role of the double-bromodomain and extraterminal (BET) family proteins in regulating ...
Williams Michael J MJ Functional Pharmacology, Department of Neuroscience, Uppsala University, Uppsala, - - 2014
In all animals managing the size of individual meals and frequency of feeding is crucial for metabolic homeostasis. In the current study we demonstrate that the noradrenalin analogue octopamine and the cholecystokinin (CCK) homologue Drosulfakinin (Dsk) function downstream of TfAP-2 and Tiwaz (Twz) to control the number of meals in ...
Avet-Rochex Amélie A Wolfson Centre for Age-Related Diseases, King's College London, London, United - - 2014
Neuronal differentiation is exquisitely controlled both spatially and temporally during nervous system development. Defects in the spatiotemporal control of neurogenesis cause incorrect formation of neural networks and lead to neurological disorders such as epilepsy and autism. The mTOR kinase integrates signals from mitogens, nutrients and energy levels to regulate growth, ...
Nakazato R R Laboratory of Molecular Pharmacology, Division of Pharmaceutical Sciences, Kanazawa University Graduate School of Medical, Pharmaceutical and Health Sciences, - - 2014
On the analogy of expression of signaling machineries for amino acid neurotransmitters, we evaluated the possible functional expression of nicotinic acetylcholine receptor (nAChR) by undifferentiated neural progenitors from neocortex of embryonic rodent brains. Neural progenitors were prepared from embryonic rat and mouse neocortex by the Percoll centrifugation method. Real time-based ...
Hurley Michael J MJ Centre for Neuroinflammation and Neurodegeneration, Division of Brain Sciences, Department of Medicine, Imperial College London, Hammersmith Campus, Du Cane Road, London, W12 0NN, UK, - - 2014
The factors which make some neurons vulnerable to neurodegeneration in Parkinson's disease while others remain resistant are not fully understood. Studies in animal models of Parkinson's disease suggest that preferential use of CaV1.3 subtypes by neurons may contribute to the neurodegenerative process by increasing mitochondrial oxidant stress. This study quantified ...
Koyama Yutaka Y Laboratory of Pharmacology, Faculty of Pharmacy, Osaka Ohtani University, 3-11-1 Nishikiori-Kita, Tonda-bayashi, Osaka 584-8540, Japan. Electronic address: - - 2014
Phenotypic conversion of astrocytes from resting to reactive (i.e., astrocytic activation) occurs in numerous brain disorders. Astrocytic activation in severely damaged brain regions often leads to glial scar formation. Because astrocytic activation and glial scar largely affect the vulnerability and tissue repair of damaged brain, numerous studies have been made ...
Ostertag Sonja - - 2014
Mercury (Hg) concentrations have increased in western Arctic beluga whales (Delphinapterus leucas) since the industrial revolution. Methylmercruy (MeHg) is a known neurotoxicant, yet little is known about the risk of exposure for beluga whales. Selenium (Se) has been linked to demethylation of MeHg in cetaceans, but its role in attenuating ...
McDermott Suzanne M SM Department of Biochemistry, University of Oxford, Oxford OX1 3QU, United - - 2014
Localized mRNA translation is thought to play a key role in synaptic plasticity, but the identity of the transcripts and the molecular mechanism underlying their function are still poorly understood. Here, we show that Syncrip, a regulator of localized translation in the Drosophila oocyte and a component of mammalian neuronal ...
Kilanczyk Ewa E Kentucky Spinal Cord Injury Research Center and Department of Neurological Surgery, University of Louisville, Louisville, Kentucky; Nencki Institute of Experimental Biology, Warsaw, - - 2014
The calcyclin-binding protein/Siah-1-interacting protein (CacyBP/SIP) is highly expressed in the brain and has been shown to regulate β-catenin-driven transcription in thymocytes. Therefore, we investigated whether CacyBP/SIP plays a role as a transcriptional regulator in brain cells. In brain-derived neurotrophic factor (BDNF)- and forskolin-stimulated rat primary cortical neurons, overexpression of CacyBP/SIP ...
Jeong Hyun-Ja HJ Biochip Research Center and Inflammatory Disease Research Center, Hoseo University, Asan, 336-795, Chungnam, Republic of - - 2014
Stillen™ has been used to treat patients with gastric mucosal ulcers and has an anti-inflammatory effect. It is well-known that neuro-inflammatory reactions are related to depression. Here we evaluated the antidepressant-like effect of Stillen™ on mice subjected to the forced swimming test (FST). Stillen™ and eupatilin (a major component of ...
Tao Ran R Lieber Institute for Brain Development, Johns Hopkins University, Baltimore, - - 2014
The single-nucleotide polymorphism rs1344706 in the zinc finger protein 804A gene (ZNF804A) shows genome-wide association with schizophrenia and bipolar disorder. Little is known regarding the expression of ZNF804A and the functionality of rs1344706. To characterize ZNF804A expression in human brain and to investigate how it changes across the life span ...
Yang Chuen-Mao CM Department of Physiology and Pharmacology and Health Aging Research Center, College of Medicine, Chang Gung University, 259 Wen-Hwa 1st Road, Kwei-San, Tao-Yuan, Taiwan, - - 2014
Matrix metalloproteinase-9 (MMP-9) plays a crucial role in pathological processes of brain inflammation, injury, and neurodegeneration. Moreover, cytokines such as interleukin-1β (IL-1β) induce expression of several inflammatory mediators in brain astrocytes, which may be important for brain inflammatory disorders. Recent studies have implicated that increased oxidative stress may contribute to ...
Viña E E Departamento de Morfología y Biología Celular - Grupo SINPOS, Universidad de Oviedo, 33006, Oviedo, - - 2014
Ionic channels play key roles in the sensory cells, such as transducing specific stimuli into electrical signals. The acid-sensing ion channel (ASIC) family is voltage-insensitive, amiloride-sensitive, proton-gated cation channels involved in several sensory functions. ASIC2, in particular, has a dual function as mechano- and chemo-sensor. In this study, we explored ...
Caron Alexandre A Institut universitaire de cardiologie et de pneumologie de Québec, 2725, chemin Sainte-Foy, Quebec (Quebec), G1V 4G5, - - 2014
DEP domain-containing mTOR-interacting protein (DEPTOR) has been recently discovered as an endogenous regulator of the mechanistic target of rapamycin complex 1 (mTORC1) and mTORC2. mTORC1 is present in the brain and there is growing evidence that its dysregulation contributes to several brain alterations. This suggests the involvement of mTOR signaling ...
Rabiee Farzaneh F Department of Biology, School of Sciences, University of Isfahan, Isfahan, Iran; Department of Cellular Biotechnology at Cell Science Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, - - 2014
Fibronectin type III domain-containing 5 protein (Fndc5) is an exercise hormone and its transcript profile in mouse showed high degree of expression in heart, skeletal muscle and brain. Our previous studies indicated a significant increase (approximately 10 fold) in mRNA level of Fndc5 when embryonic stem cells were differentiated into ...
Zhang Yu Y Department of Neurology, the First Affiliated School of Harbin Medical University, Harbin, 150001, - - 2014
Alcohol-induced neuroinflammation is mediated by the innate immunesystem. Pro-inflammatory responses to alcohol are modulated by miRNAs. The miRNA miR-339-5p has previously been found to be upregulated in alcohol-induced neuroinflammation. However, little has been elucidated on the regulatory functions of this miRNA in alcohol-induced neuroinflammation. We investigated the function of miR-339-5p ...
Hong Samin - - 2014
In physiologic and pathologic conditions of the central nervous system (CNS), astrocytes are a double-edged sword. They not only support neuronal homeostasis but also contribute to increases in neuronal demise. A large body of experimental evidence has shown that impaired astrocytes play crucial roles in the pathologic process of cerebral ...
Cui Melissa Y MY Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, Michigan - - 2014
In mammals, leptin acts on leptin receptor (LepR) -expressing neurons in the brain to suppress food intake and stimulate whole-body metabolism. A similar action of leptin on food intake has been reported in the frog Xenopus laevis and in several bony fishes. However, the intracellular signaling and neural pathways by ...
Ward Michael E ME Gladstone Institute of Neurological Diseases, Department of Neurology, Department of Medicine, Gladstone Institute of Cardiovascular Disease, University of California, San Franciso, San Francisco, CA 94158 Gladstone Institute of Neurological Diseases, Department of Neurology, Department of Medicine, Gladstone Institute of Cardiovascular Disease, University of California, San Franciso, San Francisco, CA - - 2014
Frontotemporal dementia (FTD) is the most common cause of dementia in people under 60 yr of age and is pathologically associated with mislocalization of TAR DNA/RNA binding protein 43 (TDP-43) in approximately half of cases (FLTD-TDP). Mutations in the gene encoding progranulin (GRN), which lead to reduced progranulin levels, are ...
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