Search Results
Results 1 - 50 of 1316
1 2 3 4 5 6 7 8 9 10 >
Li Yingzhi Y Department of Neurology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, P.R. - - 2014
FRMD7 mutations are associated with X-linked idiopathic congenital nystagmus (ICN); however, the underlying mechanisms whereby mutations of FRMD7 lead to ICN remain unclear. In a previous study, the first FRMD7 splice variant (FRMD7-S) was cloned and identified, and FRMD7-S was hypothesized to play a significant role in neuronal differentiation and ...
Xu Jin J Institute of Neurobiological Sciences, Chongqing Medical University, Chongqing, 400016, People's Republic of - - 2014
Brain edema formation following intracerebral hemorrhage (ICH) appears to be related with aquaporin-4 (AQP4), which is critically involved in brain volume homeostasis and water balance. Despite its importance, the regulation of AQP4 expression involved in transmembrane water movements still remains rudimentary. Many studies suggest that the internalization of several membrane-bound ...
Lee Sangmook S Center for Cellular Neurobiology and Neurodegeneration Research, Department of Biological Sciences, University of Massachusetts at Lowell, Lowell, MA 01854, USA thomas_shea@uml.edu - - 2014
Neurofilaments (NFs) are thought to provide structural support to mature axons via crosslinking of cytoskeletal elements mediated by the C-terminal region of the high molecular weight NF subunit (NF-H). Herein, we inhibited NF-H expression in differentiating mouse NB2a/d1 cells with shRNA directed against murine NF-H without affecting other NF subunits, ...
Liang Hai Jie HJ Neuroscience Research Institute and Department of Neurobiology, School of Basic Medical Sciences, Peking University, Beijing, China; Key Laboratory for Neuroscience of the Ministry of Education and Key Laboratory for Neuroscience of the National Health and Family Planning Commission, Peking University, Beijing, - - 2014
The superfamily of importin-β-related proteins is the largest class of nuclear transport receptors and can be generally divided into importins and exportins according to their transport directions. Eleven importins and seven exportins have been identified, and the expression patterns of both classes are important for their functions in nucleocytoplasmic transport ...
Park Dongkook D Department of Anatomy and Neurobiology - - 2014
Bioactive peptides are packaged in large dense-core secretory vesicles, which mediate regulated secretion by exocytosis. In a variety of tissues, the regulated release of neurotransmitters and hormones is dependent on calcium levels and controlled by vesicle-associated synaptotagmin (SYT) proteins. Drosophila express seven SYT isoforms, of which two (SYT-α and SYT-β) ...
Bailey Erin M EM Departments of Biology - - 2014
Spiral ganglion neurons (SGNs) receive input from cochlear hair cells and project from the cochlea to the cochlear nucleus. After destruction of hair cells with aminoglycoside antibiotics or noise, SGNs gradually die. It has been assumed that SGN death is attributable to loss of neurotrophic factors (NTFs) derived from hair ...
Solga Anne C AC Department of Neurology, Washington University School of Medicine, St. Louis, - - 2014
Expression profiling of distinct central nervous system (CNS) cell populations has been employed to facilitate disease classification and to provide insights into the molecular basis of brain pathology. One important cell type implicated in a wide variety of CNS disease states is the resident brain macrophage (microglia). In these studies, ...
Orta-Salazar E E Centro Universitario de Ciencias Biológicas y Agropecuarias, Universidad de Guadalajara, Zapopan, Jal. CP - - 2014
The cholinergic system is one of the neurotransmitter systems altered in Alzheimer's disease (AD), the most common form of human dementia. The objective of this work was to determine the REST/NRSF involvement in altered ChAT expression in the neocortex and hippocampus of an AD transgenic mouse (homozygous 3xTg-AD) that over-expresses ...
Hatef Azadeh A Laboratory of Integrative Neuroendocrinology, Department of Veterinary Biomedical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5B4, - - 2014
Nesfatin-1 is a naturally occurring, 82-amino acid peptide processed from the precursor nucleobindin 2 (NUCB2), a highly conserved protein among vertebrates. In fish, two isoforms of NUCB2 (NUCB2A and NUCB2B) exist, and nesfatin-1 has been identified in goldfish and Ya fish. We recently reported the presence and appetite suppressing effects ...
Bowers J Michael JM Department of Pharmacology (J.M.B., M.P.-P., C.R.R., M.M.M.), University of Maryland School of Medicine and Programs in Neuroscience (M.M.M.) and Medicine (T.E.R.), University of Maryland School of Medicine, University of Maryland, Baltimore, Baltimore, Maryland - - 2014
Sex differences in vocal communication are prevalent in both the animals and humans. The mechanism(s) mediating gender differences in human language are unknown, although, sex hormones, principally androgens, play a central role in the development of vocalizations in a wide variety of animal species. The discovery of FOXP2 has added ...
Saal Lena L Institute for Clinical Neurobiology, University of Wuerzburg, D 97078 Wuerzburg, - - 2014
Neuronal function critically depends on coordinated subcellular distribution of mRNAs. Disturbed mRNA processing and axonal transport has been found in spinal muscular atrophy and could be causative for dysfunction and degeneration of motoneurons. Despite the advances made in characterizing the transport mechanisms of several axonal mRNAs, an unbiased approach to ...
Murad Najiba N Department of Biochemistry and Molecular & Cellular Biology, Georgetown University Medical Center, Washington, DC, - - 2014
MicroRNA 184 (miR-184) is known to play a key role in neurological development and apoptosis and is highly expressed in mouse brain, mouse corneal epithelium, zebrafish lens, and human retinal pigment epithelium (RPE). However, the role of miR-184 in RPE is largely unknown. We investigated the role of miR-184 in ...
Kim Kee K KK Laboratory of Molecular Cardiology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, - - 2014
RNA-binding proteins (RBPs) regulate numerous aspects of gene expression; thus, identification of their endogenous targets is important for understanding their cellular functions. Here we identified transcriptome-wide targets of Rbfox3 in neuronally differentiated P19 cells and mouse brain by using photoactivatable ribonucleoside-enhanced cross-linking and immunoprecipitation (PAR-CLIP). Although Rbfox3 is known to ...
Schütz Burkhard B Department of Molecular Neuroscience, Institute of Anatomy and Cell Biology, Philipps-University, Robert-Koch-Straße 8, 35037, Marburg, Germany, - - 2014
Expression of Satb2 (Special AT-rich sequence-binding protein-2) elicits expression of the vesicular acetylcholine transporter (VAChT) and choline acetyltransferase (ChAT) in cultured rat sympathetic neurons exposed to soluble differentiation factors. Here, we determined whether or not Satb2 plays a similar role in cholinergic differentiation in vivo, by comparing the postnatal profile ...
Chang Chia-Yu CY Department of Neurology, Chi-Mei Medical Center, Tainan, - - 2014
Hypoxia is a common occurrence in brain tumors and traumatic brain injury. microRNA (miR)-1 participates in the regulation of brain development and neuronal function. Interestingly, miR-1 can mediate ischemia-induced injury to cardiomyocytes. This study was designed to evaluate the roles of miR-1 in hypoxia-induced insults to neurons and the possible ...
Zhang Can C Hubei Key Laboratory of Genetic Regulation and Integrative Biology, College of Life Sciences, Central China Normal University, Wuhan, 430079, Hubei, - - 2014
In order to observe the toxic effects of butyl benzyl phthalate (BBP) on zebrafish, the AChE and SOD activity of zebrafish exposed to different concentrations of BBP (0, 0.332, 0.665, 1.33 mg L(-1)) in a short-term (7d) test were determined. Semi-quantitative PCR was used to determine the mRNA transcript levels of the ...
Ohga Hirofumi H Laboratory of Marine Biology, Faculty of Agriculture, Kyushu University, Fukuoka 812-8581, - - 2014
Kisspeptin (Kiss) and its cognate receptor (Kiss1R or GPR54), implicated in the neuroendocrine control of gonadotropin-releasing hormone (GnRH) secretion in mammals, have been proposed to be key factors in reproduction, with a special role during puberty. However, the mechanisms underlying the initiation of puberty in fish are poorly understood. The ...
Schult D D Department of Neuropathology, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Erlangen, - - 2014
α-Internexin (INA) is a class IV neuronal intermediate filament protein that maintains the morphogenesis of neurons. It is expressed in developing neuroblasts and represents the major component of the cytoskeleton in cerebellar granule cells of adult central nervous system tissue. Data concerning INA expression in the human frontal pituitary lobe ...
Lu Liang L University of Alabama at Birmingham, United - - 2014
Posttranscriptional gene regulation is governed by a network of RNA-binding proteins (RBP) that interact with regulatory elements in the mRNA to modulate multiple molecular processes including splicing, RNA transport, RNA stability and translation. Mounting evidence indicates that there is a hierarchy within this network, whereby certain RBPs cross-regulate other RBPs ...
Wang Bei-Yun BY Department of Geriatrics, The Sixth People's Hospital affiliated to Shanghai Jiao Tong University, Shanghai - - 2014
Accumulating evidences demonstrated that epigenetic modification of the expression of specific genes contributed to the pathogenesis of neurological disorders with dementia, including Alzheimer's disease (AD). Emerging reports also found the reduction of hippocampal brain-derived neurotrophic factor (BDNF) in the patients and rodent models of AD, while the mechanism and functional ...
Kasuya Hikaru H Faculty of Pharmaceutical Sciences, Toho University, Funabashi, Chiba, 274-8510, - - 2014
Essential oils are mainly administered by inhalation. Administration by inhalation is considered to occur through two pathways, neurological transfer and pharmacological transfer. However, the relationship between the two routes is not clear. To clarify this relationship, we administered α-pinene, which has an anxiolytic-like effect, to mice. Emotional behavior and accumulation ...
Sun Xiaqin X State Key Laboratory of Biomembrane and Membrane Biotechnology, College of Life Sciences, PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing 100871, China; - - 2014
Axon pathology has been widely reported in Alzheimer's disease (AD) patients and AD mouse models. Herein we report that increased miR-342-5p down-regulates the expression of ankyrin G (AnkG), a protein known to play a critical role in establishing selective filtering machinery at the axon initial segment (AIS). Diminished AnkG expression ...
Seredick Steve S Institute of Neuroscience, 1254 University of Oregon, Eugene, OR 97403, - - 2014
A central problem in development is how fates of closely related cells are segregated. Lineally related motoneurons (MNs) and interneurons (INs) express many genes in common yet acquire distinct fates. For example, in mouse and chick Lhx3 plays a pivotal role in the development of both cell classes. Here, we ...
Zhang Hao-Yun HY Department of Physiology, Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders and State Key Disciplines, Medical College of Qingdao University, Qingdao 266071, China; Physiology, Medical College of Qingdao University, Qingdao 266071, China; Department of Histology and Embryology, Shandong Provincial Key Laboratory of Human Anatomy and Embryology, Weifang Medical University, Weifang 261053, - - 2014
Iron accumulation is observed in the substantia nigra of patients with Parkinson's disease. However, it is unknown whether neurotrophic factors, brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF) participate in the modulation of neuronal iron metabolism. Here, we investigated the effects and underlying mechanisms of BDNF and ...
Grabenstatter Heidi L HL Department of Pediatrics, Section of Neurology, Translational Epilepsy Research Program, University of Colorado, AMC, Aurora, Colorado, - - 2014
Temporal lobe epilepsy (TLE) is frequently medically intractable and often progressive. Compromised inhibitory neurotransmission due to altered γ-aminobutyric acid (GABA)A receptor α4 subunit (GABAA Rα4) expression has been emphasized as a potential contributor to the initial development of epilepsy following a brain insult (primary epileptogenesis), but the regulation of GABAA ...
Wang Shukun S The State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China University of Chinese Academy of Sciences, Beijing, - - 2014
Astrocyte differentiation is essential for late embryonic brain development, and autophagy is active during this process. However, it is unknown whether and how autophagy regulates astrocyte differentiation. Here, we show that Atg5, which is necessary for autophagosome formation, regulates astrocyte differentiation. Atg5 deficiency represses the generation of astrocytes in vitro ...
Rajaram Kamya K Department of Biological Sciences, Vanderbilt University, Nashville, - - 2014
Background: Adult zebrafish spontaneously regenerate their retinas after damage. Although a number of genes and signaling pathways involved in regeneration have been identified, the exact mechanisms regulating various aspects of regeneration are unclear. microRNAs were examined for their potential roles in regulating zebrafish retinal regeneration. Results: To investigate the requirement ...
Cai MuDan - - 2014
Amyotrophic lateral sclerosis (ALS) is an adult onset disease that produces gradual motor neuron cell death in the spinal cord (SP). Recently, transactive response DNA-binding protein 43 kDa (TDP-43), a critical component of insoluble ubiquitinated inclusions, has received attention in the treatment of neurodegenerative disorders, including frontotemporal lobar degeneration (FTLD) ...
Mojsa B B 1] Institut de Génétique Moléculaire de Montpellier UMR 5535 CNRS, Montpellier 34293, France [2] Université Montpellier 2, Montpellier 34095, France [3] Université Montpellier 1, Montpellier 34967, - - 2014
Neuronal apoptosis induced by survival factor deprivation is strongly regulated at the transcriptional level. Notably, the nuclear factor of activated T cell (NFAT) transcription factors have an important role in the control of the survival/death fate of neurons. However, the mechanisms that regulate NFAT activity in response to apoptotic stimuli ...
Bolós Marta M Menzies Research Institute Tasmania, - - 2014
Amyloid-β precursor protein (APP) is well studied for its role in Alzheimers disease, although its normal function remains uncertain. It has been reported that APP stimulates the proliferation and neuronal differentiation of neural stem / progenitor cells (NSPCs). In this study, we examined the role of APP in NSPC differentiation. ...
Dean Benjamin J - - 2014
The conserved habenular nuclei function as a relay system connecting the forebrain with the brain stem. They play crucial roles in various cognitive behaviors by modulating cholinergic, dopaminergic and serotonergic activities. Despite the renewed interest in this conserved forebrain region because of its importance in regulating aversion and reward behaviors, ...
Bogdanovic Elena E Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, 2075 Bayview Ave, D704, Toronto, ON, Canada M4N 3M5. Electronic address: - - 2014
Isocitrate dehydrogenase 1 (IDH1) is an evolutionarily conserved enzyme that catalyzes the interconversion of isocitrate to α-ketoglutarate with the concomitant reduction of NADP(+) to NADPH. IDH1 has previously been shown to participate in lipid biosynthesis in various tissues such as the liver and adipose tissue. We examined the potential role ...
Brown Rse R Centre for Neuroendocrinology and Departments of Anatomy, University of Otago, Dunedin, New - - 2014
Hyperprolactinaemia is a major cause of infertility in both males and females, but the mechanism by which prolactin inhibits the reproductive axis is not clear. The aim of the present study was to test the hypothesis that elevated prolactin causes suppression of kisspeptin expression in the hypothalamus, resulting in reduced ...
Yeung Joanna J http://orcid.org/0000-0003-0551-5305 Department of Medical Genetics, Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada V5Z4H4 - - 2014
Math1 is the defining molecule of the cerebellar rhombic lip and Pax6 is downstream in the Math1 pathway. In the present study, we discover that Wntless (Wls) is a novel molecular marker of the cells in the interior face of the rhombic lip throughout normal mouse cerebellar development. Wls expression ...
Zhang Ji J Center of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, 210009, - - 2014
Ammonia is considered to be the main neurotoxin responsible for hepatic encephalopathy resulting from liver failure. Liver failure has been reported to alter expression and activity of P-glycoprotein (P-gp) and multidrug resistance-associated protein 2 (Mrp2) at the blood-brain barrier (BBB). The aim of this study was to investigate whether ammonia ...
He Lu L Department of Anatomy and Histology, School of Basic Medical Sciences, Tianjin Medical University, 22 Qixiangtai Road, Tianjin, 300070, - - 2014
Previous studies have suggested that progesterone may be involved in neuroprotection by preventing brain edema. In this study, we assessed the effects of progesterone on aquaporin-4 (AQP4) expression in an ischemia/reperfusion model of cultured rat astrocytes, and further explored the possible role of the protein kinase C (PKC) pathway in ...
Lu Kwok-Tung KT Department of Life Science, National Taiwan Normal University, Taipei, - - 2014
Traumatic brain injury (TBI) is one of the most prevalent causes of worldwide mortality and morbidity. We previously had evidenced that TBI induced Na-K-2Cl co-transporter (NKCC1) upregulation in hippocampus. Here, we aim to investigate the role of NKCC1 in TBI-induced neurogenesis and the detailed mechanisms. The TBI-associated alternations in the ...
Xu Niangui N Department of Neurology, The Second Xiangya Hospital of the Central South University, Changsha, China - - 2014
The possible roles played by growth arrest and DNA damage-inducible gene 34 (GADD34) in Alzheimer's disease (AD) are so far less understood. In this study, we found that GADD34 was increased in the brains of AD transgenic J20 mice. The deposition of β-amyloid (Aβ) peptide is the main component of ...
Xu Da-Ping DP State Key Laboratory of Quality Research in Chinese Medicine and Institute of Chinese Medical Sciences, University of Macau, Avenue Padre Tomás Pereira S.J., Macao SAR, China; Department of Applied Biology and Chemical Technology, Institute of Modern Chinese Medicine, Hong Kong Polytechnic University, Hong Kong, - - 2014
The natural product tetramethylpyrazine (TMP) has a variety of biologic activities, including neuroprotection. Nitrones are powerful free radical scavengers. We have designed and synthesized a TMP derivative, TN-2, which is armed with two nitrone moieties. In this study, we investigated the neuroprotective effect of TN-2 against 6-hydroxydopamine (6-OHDA)-induced neurotoxicity in ...
Hollins Sharon L - - 2014
MicroRNAs (miRNAs) play a pivotal role in coordinating messenger RNA (mRNA) transcription and stability in almost all known biological processes, including the development of the central nervous system. Despite our broad understanding of their involvement, we still have a very sparse understanding of specifically how miRNA contribute to the strict ...
Guo Weiwei - - 2014
BackgroundThe impact of miRNA differential expression on the auditory epithelium stem cell development in postnatal rats is not clear. The present study was designed to analyze miRNA expression in the organ of Corti of neonatal and adult rats.MethodsThe cochleae of newborn (P0) and adult (P30) Sprague-Dawley rats were dissected in ...
Laporta Jimena J Departments of Dairy - - 2014
Calcium homeostasis during lactation is critical for maternal and neonatal health. We previously showed that non-neuronal/peripheral serotonin (5-hydroxytryptamine, 5-HT) causes the lactating mammary gland to synthesize and secrete parathyroid hormone-related protein (PTHrP) in an acute fashion. Here, using a mouse model we found that genetic inactivation of tryptophan hydroxylase 1 ...
Lenihan Joan A JA School of Biochemistry and Cell Biology, University College Cork, Cork, - - 2014
LNX1 and LNX2 are E3 ubiquitin ligases that can interact with Numb - a key regulator of neurogenesis and neuronal differentiation. LNX1 can target Numb for proteasomal degradation, and Lnx mRNAs are prominently expressed in the nervous system, suggesting that LNX proteins play a role in neural development. This hypothesis ...
Wakuda Tomoyasu T Department of Psychiatry, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka 431-3192, - - 2014
Epidemiological studies suggest that perinatal complications, particularly hypoxia-related ones, increase the risk of schizophrenia. Recent genetic studies of the disorder have identified several putative susceptibility genes, some of which are known to be regulated by hypoxia. It can be postulated therefore that birth complications that cause hypoxia in the fetal ...
Dávila David D Department of Physiology and Medical Physics and RCSI Centre for the Study of Neurological Disorders (CSND), Royal College of Surgeons in Ireland, 123 St Stephen's Green, Dublin 2, Ireland. Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain. daviddav@ucm.es - - 2014
Neurons face a changeable microenvironment and therefore need mechanisms that allow rapid switch on/off of their cyto-protective and apoptosis-inducing signaling pathways. Cellular mechanisms which control apoptosis activation include the regulation of pro/anti-apoptotic mRNAs through their 3'-untranslated region (UTR). This region holds binding elements for RNA-binding proteins (RBPs) which can control ...
Toyoda Atsushi A United Graduate School of Agricultural Science, Tokyo University of Agriculture and Technology, Fuchu, Japan; College of Agriculture, Ibaraki University, Ibaraki, Japan; Ibaraki University Cooperation between Agriculture and Medical Science (IUCAM), Ibaraki, - - 2014
The hippocampus plays a key role in learning and emotional regulation. The hippocampus' function varies along its septotemporal axis, with the septal pole being more frequently involved in spatial learning and memory, and the temporal pole playing a greater role in emotional behaviors. In this study, we present findings aimed ...
Lue Lih-Fen LF Laboratory of Neuroregeneration, Banner Sun Health Research Institute, Sun City, Arizona, - - 2014
Triggering receptor expressed by myeloid cells 2 (TREM2), a member of immunoglobulin superfamily, has anti-inflammatory phagocytic function in myeloid cells. Several studies have shown that TREM2 gene variant rs75932628-T increased the risks for Alzheimer's disease (AD), Parkinson's disease, frontotemporal dementia, and amyotrophic lateral sclerosis. It has been suggested that the ...
Song Honghua H Key Laboratory of Neuroregeneration, Co-innovation Center of Neuroregeneration, Nantong University, 19 Qixiu Road, 226007, Nantong, People's Republic of - - 2014
The Wingless/Integrated (Wnt) signaling pathway plays important roles in central nervous system (CNS) development and regeneration, and β-catenin, the central component, has been considered in association with adult neurogenesis. To decipher its roles on spontaneous spinal cord regeneration, we cloned β-catenin from Gekko japonicus and examined its function in regenerating ...
Draganova Kalina K Cell and Developmental Biology Division, Institute of Anatomy, University of - - 2014
The fate of neural progenitor cells (NPC) is determined by a complex interplay of intrinsic programs and extrinsic signals, very few of which are known. β-catenin transduces extracellular Wnt signals, but also maintains adherens junctions integrity. Here, we identify for the first time the contribution of β-catenin transcriptional activity as ...
Zanotti-Fregonara Paolo P aUniversity of Bordeaux, CNRS, INCIA, UMR 5287, Talence bCEA, DSV, I2BM, SHFJ, Orsay cINSERM, CEA, University Paris sud, University Paris Descartes, Research Unit 1000 'NeuroImagery & Psychiatry', Orsay dCEA, DSV, I2BM, Neurospin, Gif-sur-Yvette, France eDepartment of Information Engineering, University of Padova, Padova, - - 2014
[C]Befloxatone is a highly specific, reversible, and selective radioligand for brain PET imaging of monoamine oxidase-A and can be quantified by a two-tissue compartment model (2TCM) and an arterial input function. The aims of the present study were the following: (a) to assess whether in-vivo protein concentration, as measured by ...
1 2 3 4 5 6 7 8 9 10 >