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Morais-de-Sá Eurico E The Gurdon Institute, The Department of Genetics, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, - - 2014
The Drosophila anterior-posterior axis is specified when the posterior follicle cells signal to polarise the oocyte, leading to the anterior/lateral localisation of the Par-6/aPKC complex and the posterior recruitment of Par-1, which induces a microtubule reorganisation that localises bicoid and oskar mRNAs. Here we show that oocyte polarity requires Slmb, ...
Hoffmann Hanne M HM Department of Reproductive Medicine and the Center for Reproductive Science and Medicine, University of California, San Diego, LA Jolla, CA (H.M.H., A.T., H.X., A.S.K., P.L.M.); Department of Human Genetics, University of Michigan, Ann Arbor, MI - - 2014
The known genetic causes of idiopathic hypogonadotropic hypogonadism (IHH) are often associated with the loss of gonadotropin-releasing hormone (GnRH) neurons leading to disruption of the hypothalamic pituitary gonadal axis and subfertility. The majority of IHH cases have unknown origins and likely arise from compound mutations in more than one gene. ...
Michaeli Shulamit S The Mina and Everard Goodman Faculty of Life Sciences, and Advanced Materials and Nanotechnology Institute, Bar-Ilan University, Ramat-Gan 52900, Israel. Electronic address: - - 2014
The protozoan parasite Trypanosoma brucei is the causative agent of African sleeping sickness and the wasting disease, nagana, in cattle. The parasite is transmitted to the mammalian host by the bite of a tsetse fly. These parasites lack transcriptional regulation, and their gene expression is mainly regulated post-transcriptionally. Changes in ...
Gao Jiancao J Shaanxi Key Laboratory of Molecular Biology for Agriculture, College of Animal Science and Technology, Northwest A&F University, 22 Xinong Road, Yangling, 712100, Shaanxi, - - 2014
Bisphenol A (BPA), a wide distributed endocrine-disrupting chemical, has attracted many attentions. To explore the effect of BPA on hepatic metabolic pathways in Gobiocypris rarus, full-length cDNAs of pregnane X receptor (PXR) and two sulfotransferases (SULT1 ST4 and SULT1 ST6) were firstly isolated and characterized. We detected tissues distribution of ...
Hiradate Yuuki - - 2014
Neurotensin (NT) has multiple functions, ranging from acting as a neurotransmitter to regulating intestinal movement. However, its function in reproductive physiology is unknown. Here, we investigated the functions of NT receptors (NTR1/2) and effect of NT on sperm function using mouse epididymal spermatozoa. Sperm protein tyrosine phosphorylation, one of the ...
Sood Rapita R Department of Human Biology, Faculty of Natural Sciences, University of Haifa, 199 Aba Khoushy Ave. Mt. Carmel, Haifa 3498838, - - 2014
The pro-inflammatory enzyme cyclooxygenase-2 (COX-2) is regularly expressed in the hippocampal neurons, but its role in emotional trauma is not known. Here we show that a single acute stress caused by a near-drowning experience results in heightened anxiety-like behavior one month after the trauma. Biochemical analyses of dorsal and ventral ...
Wurth Laurence L Architecture et Réactivité de l'ARN, Université de Strasbourg, Centre National de la Recherche Scientifique, Institut de Biologie Moléculaire et Cellulaire, 67084 Strasbourg, - - 2014
Mammalian mRNAs are generated by complex and coordinated biogenesis pathways and acquire 5'-end m(7)G caps that play fundamental roles in processing and translation. Here we show that several selenoprotein mRNAs are not recognized efficiently by translation initiation factor eIF4E because they bear a hypermethylated cap. This cap modification is acquired ...
Korzan Wayne J WJ Stanford University, United - - 2014
In many social species, individuals influence the reproductive capacity of conspecifics. In a well-studied African cichlid fish species, Astatotilapia burtoni, males are either dominant (D) and reproductively competent or non-dominant (ND) and reproductively suppressed as evidenced by reduced gonadotropin releasing hormone (GnRH1) release, regressed gonads, lower levels of androgens and ...
Song Jiasheng J State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, - - 2014
Juvenile hormone (JH) prevents insect larval metamorphosis and stimulates processes for adult reproduction. Krüppel-homolog 1 (Kr-h1), a zinc finger transcription factor, is shown to mediate the anti-metamorphic effect of JH in both holometabolous and hemimetabolous insects. However, the role of Kr-h1 in JH-mediated reproduction has not been determined. Using the ...
Bouleau Aurélien - - 2014
The molecular mechanisms underlying and determining egg developmental competence remain poorly understood in vertebrates. Nucleoplasmin (Npm2) is one of the few known maternal effect genes in mammals but this maternal effect has never been demonstrated in non-mammalian species. A link between developmental competence and the abundance of npm2 maternal mRNA ...
Bloomfield Gareth G MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge, CB2 0QH, UK. Electronic address: - - 2014
Differentiation involves the expression of certain latent cellular characteristics and the repression of others. A new study has revealed how Paramecium uses short RNAs to delete information from the somatic genome of one of its two sexes.
Kobayashi Noriko N Laboratory of Sericulture & Entomoresources, Graduate School of Bioagricultural Sciences, Nagoya University, Chikusa, Nagoya, Aichi 464-8601, - - 2014
To better understand the molecular mechanisms of diapause initiation, we used the sensitive cDNA subtraction (selective amplification via biotin- and restriction-mediated enrichment) method and isolated a novel gene expressed abundantly in diapause eggs of the silkworm, Bombyx mori, which encodes a homolog of the human oxidation resistance 1 (OXR1) protein. ...
Belles Xavier X Institut de Biologia Evolutiva (Universitat Pompeu Fabra-CSIC), Passeig Maritim de la Barceloneta 37, 0803 Barcelona, Spain. Electronic address: - - 2014
Recent studies on transcription factor E93 revealed that it triggers adult morphogenesis in Blattella germanica, Tribolium castaneum and Drosophila melanogaster. Moreover, we show here that Krüppel-h1 (Kr-h1), a transducer of the antimetamorphic action of juvenile hormone (JH), represses E93 expression. Kr-h1 is upstream of E93, and upstream of Kr-h1 is ...
Zhang X X College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, 210095, China; Dairy Cattle Research Center, Shandong Academy of Agricultural Science, Jinan, 250131, China; College of Animal Science, Henan Institute of Science and Technology, Xinxiang, 453000, - - 2014
Katanin p60 subunit A-like 1 (KATNAL1) is an ATPase that regulates Sertoli cell microtubule dynamics and sperm retention. We evaluated one novel splice variant and characterized the promoter and a functional single nucleotide polymorphism (SNP) of the bovine KATNAL1 gene to explore its expression pattern, possible regulatory mechanism and relationship ...
Perrotta Ida I Departments of *Biology, Ecology and Earth Sciences (Di.B.E.S.T.) †Department of Pharmacy and Health and Nutritional Sciences, University of Calabria, Arcavacata di Rende ‡Post-graduate School in Clinical Pathology §Centro Sanitario, University of Calabria, Rende, Cosenza, - - 2014
Varicocele, an abnormal tortuosity and dilation of veins of the pampiniform plexus, is the most common identifiable and correctable cause of male infertility. It is now becoming apparent that signaling through vitamin A metabolites, such as all-trans retinoic acid (ATRA), is indispensable for spermatogenesis and disruption of retinoic acid receptor-α ...
Kong Y Y Education Ministry Key Laboratory of Integrated Management of Crop Diseases and Pests, College of Plant Protection, Nanjing Agricultural University, Nanjing, - - 2014
Ecdysone 20-monooxygenase (E20MO), a cytochrome P450 monooxygenase (CYP314A1), catalyses the conversion of ecdysone (E) to 20-hydroxyecdysone (20E). We report here the cloning and characterization of the Halloween gene Shade (Shd) encoding E20MO in the Colorado potato beetle, Leptinotarsa decemlineata. LdSHD has five conserved motifs typical of insect P450s, ie the ...
Lim W W Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul, Republic of - - 2014
Hen egg protein (HEP21) is a 21-kDa secreted protein and has a single copy of the Ly6/uPAR domain. Although HEP21 is expressed primarily in the chicken oviduct, its biological function(s) in the reproductive system of chickens is not known. Thus, in the present study, we investigated expression patterns of HEP21 ...
Salvolini Eleonora E Department of Clinical and Molecular Sciences-Histology, Università Politecnica delle Marche, Via Tronto 10/A, 60126, Ancona, - - 2014
Impaired male fertility may have a variety of causes, among which asthenozoospermia. In its etiology, several bioactive substances, such as cytokines may be involved. In this context, our aim was to evaluate the expression of interleukin-1β, cyclooxygenase-2, and hypoxia-inducible factor-1α, in spermatozoa isolated from normospermic fertile donors and asthenozoospermic infertile ...
Vásquez-Doorman Constanza C Department of Molecular Biosciences, Northwestern University, Evanston, Illinois, United States of - - 2014
Mechanisms that enable injury responses to prompt regenerative outgrowth are not well understood. Planarians can regenerate essentially any tissue removed by wounding, even after decapitation, due to robust regulation of adult pluripotent stem cells of the neoblast population. Formation of pole signaling centers involving Wnt inhibitors or Wnt ligands promotes ...
Haimovici Aladin A Division of Experimental Pathology, Institute of Pathology, University of Bern, Switzerland; Graduate School for Cellular and Biomedical Sciences, University of Bern, - - 2014
The PU.1 transcription factor is essential for myeloid development. We investigated if the microtubule-associated protein 1S (MAP1S) is a novel PU.1 target with a link to autophagy, a cellular recycling pathway. Comparable to PU.1, MAP1S expression was significantly repressed in primary AML blasts as compared to mature neutrophils. Accordingly, MAP1S ...
Marie-Orleach Lucas - - 2014
Sexual selection has initially been thought to occur exclusively at the precopulatory stage in terms of contests among males and female mate choice, but research over the last four decades revealed that it often continues after copulation through sperm competition and cryptic female choice. However, studying these postcopulatory processes remains ...
He Yuxuan Y College of Veterinary Medicine, Gansu Agricultural University, Lanzhou 730070, - - 2014
The aim of the study was to determine the effects of heavy ion radiation (HIR) on ram sperm quality during 24h of in vitro liquid storage at 15°C, and identify the most appropriate dose which did not injure, but actually improved sperm quality and confirmed the relationship between highly expressed ...
Zhao Lei L College of Life Science, Qufu Normal University, 273165, - - 2014
RFamide-related peptides (RFRPs) are orthologous to gonadotropin-inhibitory hormone (GnIH) inhibiting gonadotropin release. There are only two RFRP sequences (RFRP-1 and RFRP-3) encoded in rodents. RFRP-3, which was considered as a hypothetical inhibitor on GnRH, shows a stimulatory effect on the male Syrian and male Siberian hamster in short days. As ...
Mao Feifei F State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, CAS, - - 2014
Hedgehog (Hh) signaling pathway plays a very important role in metazoan development by controlling pattern formation. Drosophila imaginal discs are subdivided into anterior and posterior compartments which derive from adjacent cell populations. The anterior/posterior (A/P) boundaries which are critical to maintain the position of organizers are established by a complex ...
Huang Y Y Key Laboratory of Entomology and Pest Control Engineering, College of Plant Protection, Southwest University, Chongqing, - - 2014
In eukaryotes, microRNAs (miRNAs) are small, conserved, noncoding RNAs that have emerged as critical regulators of gene expression. The oriental fruit fly Bactrocera dorsalis is one of the most economically important fruit fly pests in East Asia and the Pacific. Although transcriptome analyses have greatly enriched our knowledge of its ...
Fusani Leonida L Department of Life Science and Biotechnology, University of Ferrara, 44121 Ferrara, Italy. Electronic address: - - 2014
Sex steroids control vertebrate behavior by modulating neural circuits specialized for sex steroid sensitivity. In birds, receptors for androgens (AR) and estrogens (ERα) show conserved expression in neural circuits controlling copulatory and vocal behaviors. Male golden-collared manakins have become a model for evaluating hormonal control of complex physical courtship displays. ...
Armesto Paula P IFAPA Centro El Toruño, 11500 El Puerto de Santa María (Cádiz), - - 2014
In the present work, five genes encoding different Na(+),K(+) ATPase (NKA) α-isoforms in the teleost Solea senegalensis are described for the first time. Sequence analysis of predicted polypeptides revealed a high degree of conservation across teleosts and mammals. Phylogenetic analysis clustered the five genes into three main clades: α1 (designated ...
Gao Su S Marine Life Science College, Ocean University of China, 5 Yushan Road, Qingdao, 266003, Shandong, People's Republic of - - 2014
To determine the endocrine disrupting effect of semicarbazide, an emerging water contaminant, the changes in transcript levels of hepatic estrogen-response genes including vitellogenin-1 (vtg-1), estrogen receptor α (ERα), and estrogen receptor β (ERβ) were measured in male and female zebrafish exposed to semicarbazide with or without exogenous 17β-estradiol (E2). Exposure ...
Liu Jinghui J Graduate School of Animal and Food Hygiene, Obihiro University of Agriculture and Veterinary Medicine, Obihiro 080-8555, - - 2014
We have previously shown that polymorphonuclear neutrophils (PMNs) are present in bovine oviduct fluid under physiological conditions, and that the oviduct provides a microenvironment that protects sperm from phagocytosis by PMNs. Alpha 1-acid glycoprotein (AGP) is a major acute-phase protein produced mainly in the liver that has immunomodulatory functions. AGP ...
Huang Xiaoshuai X College of Ocean and Earth Sciences, Xiamen University, Xiamen 361005, - - 2014
Insulin-like androgenic gland hormone (IAG) produced by androgenic gland (AG) in male crustaceans is regarded as a key regulator of sex differentiation. As a member of the insulin/insulin-like growth factor family, IAG is also likely involved in regulating somatic growth. In this study, a full-length cDNA of IAG (termed Sp-IAG) ...
Yu Changmao C School of Life Sciences, Xiamen University, Xiamen, Fujian, 361102, - - 2014
In this study we have investigated the anatomic sites of expression and developmental expression patterns of two cathepsin B-like cysteine proteases (AC-cathB-1, -2) of Angiostrongylus cantonensis. The immunolocalization results revealed that native AC-cathBs were found present in the L1 and L3 larvae, female and male adults, and the AC-cathBs were ...
Bolkan Bonnie J BJ Oregon Institute of Occupational Health Sciences, Oregon Health & Science University, Portland, OR, 97239, - - 2014
Accumulations of Tau, a microtubule-associated protein, into neurofibrillary tangles is a hallmark of Alzheimer's disease and other tauopathies. However, the mechanisms leading to this pathology are still unclear: the aggregates themselves could be toxic or the sequestration of Tau into tangles might prevent Tau from fulfilling its normal functions, thereby ...
Jalkanen Aimee L AL Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, - - 2014
While the phenomenon of polyadenylation has been well-studied, the dynamics of poly(A) tail size and its impact on transcript function and cell biology are less well-appreciated. The goal of this review is to encourage readers to view the poly(A) tail as a dynamic, changeable aspect of a transcript rather than ...
Hu Meng-Wen - - 2014
Ppp2r1a encodes the scaffold subunit Aα of protein phosphatase 2A (PP2A), which is an important and ubiquitously expressed serine threonine phosphatase family, and plays a critical role in many fundamental cellular processes. To identify the physiological role of PP2A in female germ cell meiosis, we selectively disrupted Ppp2r1a expression in ...
Aarabi Mahmoud M Department of Biomedical and Molecular Sciences, School of Medicine, Queen's University, Kingston, Ontario, - - 2014
To determine the levels of postacrosomal WW binding protein (PAWP) in the spermatozoa of men that were used clinically for intracytoplasmic sperm injection (ICSI) and to correlate them with infertility treatment outcomes. Prospective clinical and laboratory study. University-based laboratory and infertility clinic. Men undergoing ICSI for the treatment of couples' ...
Petrova Olga E OE Department of Biological Sciences, Binghamton University, Binghamton, NY - - 2014
Cyclic di-GMP is a conserved signaling molecule regulating the transitions between motile and sessile modes of growth in a variety of bacterial species. Recent evidence suggests that Pseudomonas species harbor separate intracellular pools of c-di-GMP to control different phenotypic outputs associated with motility, attachment, and biofilm formation, with multiple diguanylate ...
Nyuji Mitsuo M 1 Laboratory of Marine Biology, Faculty of Agriculture, Kyushu University, Fukuoka 812-8581, - - 2014
Understanding puberty is important for establishing aquaculture in fish. In this study, we analyzed the timing and completion of pubertal development along with changes in pituitary gonadotropin genes (fshb and lhb) in cultured chub mackerel (Scomber japonicus). At 45 days post-hatching (dph), gonadal sex differentiation was observed. The onset of ...
Murozumi Norikazu N Department of Biological Sciences, Graduate School of Science and Technology, Kumamoto University, Kumamoto 860-8555, - - 2014
Follicle-stimulating hormone (FSH), a glycoprotein hormone, is circulated from the pituitary and functions by binding to a specific FSH receptor (FSHR). FSHR is a G-protein-coupled, seven-transmembrane receptor linked to the adenylyl cyclase or other pathways and is expressed in gonadal somatic cells. In some non-mammalian species, fshr expression is much ...
Cassault-Meyer Estelle E University of Caen, Institute of Biology, Network on Risks MRSH-CNRS, Esplanade de la Paix, 14032 Caen Cedex, France; CRIIGEN, 40 rue de Monceau, 75008 Paris, France. Electronic address: - - 2014
Roundup is the major pesticide used in agriculture worldwide; it is a glyphosate-based herbicide. Its molecular effects are studied following an acute exposure (0.5%) of fifteen 60-day-old male rats during an 8-day period. Endocrine (aromatase, estrogen and androgen receptors, Gper1 in testicular and sperm mRNAs) and testicular functions (organ weights, ...
Yang Congwen C State Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing 400716, - - 2014
Vitellogenin (Vg) is synthesized in the fat body of the female silkworm Bombyx mori and transported to the oocyte as a source of nutrition for embryo development. It is well known that ecdysone regulates physiological, developmental and behavioral events in silkworm. However, it is still not clearly how the ecdysone ...
Wong Ryan Y RY Department of Biological Sciences, W.M. Keck Center for Behavioral Biology, North Carolina State University, Raleigh, N.C., - - 2014
Choosing mates is a commonly shared behavior across many organisms, with important fitness consequences. Variations in female preferences can be due in part to differences in neural and cellular activity during mate selection. Initial studies have begun to identify putative brain regions involved in mate preference, yet the understanding of ...
Vieira Cecilia Stahl - - 2014
The triatomine, Rhodnius prolixus, is a major vector of Trypanosoma cruzi, the causative agent of Chagas disease in Latin America. It has a strictly blood-sucking habit in all life stages, ingesting large amounts of blood from vertebrate hosts from which it can acquire pathogenic microorganisms. In this context, the production ...
Niu Hui-Ran HR College of Life Science and Technology, Southwest University for Nationalities, Chengdu 610041, PR - - 2014
We cloned and sequenced four pivotal cDNAs involved in DNA structural maintenance (H1F0 and TOP1) and the cell cycle (CLTA and CDK1) from yak oocytes. In addition, we studied the consequences of freezing-thawing (F/T) processes on the expression of their mRNA transcripts in yak immature and in vitro matured (MII) ...
Muggenhumer Dominik D Department of Chromosome Biology, Max F. Perutz Laboratories, University of Vienna, Dr. Bohr Gasse 9/5, A-1030 Vienna, - - 2014
MicroRNAs (miRNAs) are ∼21nt nucleotide long, single-stranded noncoding RNAs that regulate gene expression. Biogenesis of miRNAs is mediated by the two RNase III-like enzymes Drosha and Dicer. Here we study miRNA biogenesis during maturation of Xenopus oocytes to eggs using microinjection of pri-miRNAs. We show that processing of exogenous and ...
Sanchez-Ferras Oraly O Molecular Genetics of Development Laboratory, Department of Biological Sciences and BioMed Research Center, Faculty of Sciences, University of Quebec at Montreal - - 2014
Pax3 encodes a paired-box transcription factor with key roles in neural crest and neural tube ontogenesis. Robust control of Pax3 neural expression is ensured by two redundant sets of cis-regulatory modules (CRMs) that integrate anterior-posterior (such as Wnt-βCatenin signaling) as well as dorsal-ventral (such as Shh-Gli signaling) instructive cues. In ...
Pereira Roberta V RV Núcleo de Pesquisas em Ciências Biológicas, Instituto de Ciências Exatas e Biológicas - ICEB2, Universidade Federal de Ouro Preto, Morro do Cruzeiro, Ouro Preto, MG, - - 2014
Small ubiquitin-like modifier (SUMO) conjugation of proteins occurs through a concert action of enzymes using a similar ubiquitination mechanism. After a C-terminal peptide is cleaved from the SUMO precursor by a protease to reveal a di-glycine motif, SUMO is activated by an E1 enzyme (Aos1/Uba2) and conjugated to target proteins ...
Carneiro Vitor Coutinho VC Instituto de Bioquímica Médica, Programa de Biologia Molecular e Biotecnologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, - - 2014
Treatment and control of schistosomiasis relies on the only available drug, praziquantel, and the search for alternative chemotherapeutic agents is therefore urgent. Egg production is required for the transmission and immunopathology of schistosomiasis and females of S. mansoni lay 300 eggs daily. A large fraction of the total mRNA in ...
Santana Sharlene E SE Department of Biology and Burke Museum, University of Washington, Seattle, WA 98195, USA - - 2014
Facial colour patterns and facial expressions are among the most important phenotypic traits that primates use during social interactions. While colour patterns provide information about the sender's identity, expressions can communicate its behavioural intentions. Extrinsic factors, including social group size, have shaped the evolution of facial coloration and mobility, but ...
Zhang Yan Y College of Agronomy and Biotechnology, China Agricultural University, Beijing 100193, P. R. - - 2014
Cucumber (Cucumis sativus L.) is a typical monoecious vegetable with individual male and female flowers, and has been used as a model plant for sex determination. It is well known that sex differentiation of cucumber can be regulated by phytohormones, such as gibberellic acid (GA) and ethylene. The molecular mechanism ...
Shannonhouse John L JL Institute for Neuroscience, Texas A&M University, College Station, Texas 77843, - - 2014
The present study sought novel changes to the hamster testicular transcriptome during modulation of fertility by well-characterized photoperiodic stimuli. Transition from long days (LD, 14 h light/day) to short days (SD, 10 h light/day) triggered testicular regression (61% reduction of testis weight, relative to LD) in SD-sensitive (SD-S) hamsters within ...
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