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Results 251 - 300 of 3202
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Zhai Jiajie J Department of Pharmacology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, Guangdong 510040, P.R. - - 2014
The present study aimed to explore the feasibility of using antisense connexin (Cx) treatment to promote corneal wound healing, and to investigate the changes of Cx gap junction proteins in terms of mRNA, protein expression and distribution in human corneas that were diseased due to various causes. A total of ...
Farimani Sanoee Marzieh M Endometrium and Endometriosis Research Center, Hamadan University of Medical Sciences, Hamadan, Iran. - - 2014
Background: In fertile women, glycodelin and glutathione peroxidase 3 (GPx3) genes expression rises during the luteal phase, with a peak occurring during the implantation window. The expression of these genes decreases in women with myomas. To determine whether myomectomy would reverse glycodelin and GPx3 expression, we evaluated the transcript levels ...
Chuanwu Zhu Z Department of Hepatology, The Affiliated Infectious Disease Hospital of Soochow University, Suzhou, - - 2014
Telomerase activity is closely associated with the expression of human telomerase reverse transcriptase (hTERT) mRNA; although it can be induced in hepatocytes during liver regeneration, its dynamic change in patients with liver failure has remained unclear. We investigated the variation and significance of hTERT mRNA expression in peripheral blood mononuclear ...
Fang De-Ren DR Department of Dermatology, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China. Electronic address: - - 2014
To analyze the dynamic expression of Wnt family member 5A (Wingless-type MMTV integration Wnt site family, member 5a) in murine hair cycle and its inhibitory effects on follicle in vivo. Situ hybridization in full-thickness skin was used to observe the change of mouse protein expression in different growth stages, and ...
Osuka Koji K Aichi Medical University, Neurological Surgery, Nagakute, Aichi, Japan ; - - 2014
Chronic subdural hematoma (CSDH) is considered to be an inflammatory disease. Eosinophils are frequently expressed in the outer membrane of CSDH and are major sources of transforming growth factor-β (TGF-β). The Smad signaling pathway, which is activated by TGF-β, has been shown to be involved with fibrosis. In the present ...
Donati Giacomo G Centre for Stem Cells and Regenerative Medicine, Kings College London, London SE1 9RT, United - - 2014
It has long been recognized that the hair follicle growth cycle and oscillation in the thickness of the underlying adipocyte layer are synchronized. Although factors secreted by adipocytes are known to regulate the hair growth cycle, it is unclear whether the epidermis can regulate adipogenesis. We show that inhibition of ...
Aqrawi Lara A LA Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway. - - 2014
Ro52 is an E3 ubiquitin ligase with a prominent regulatory role in inflammation. The protein is a common target of circulating autoantibodies in rheumatic autoimmune diseases, particularly Sjögren's syndrome (SS). In this study we aimed to investigate the expression of the SS target autoantigen Ro52 in salivary glands of patients ...
Kostaki Maria M Department of Biological Chemistry, University of Athens Medical School, 11527, Athens, - - 2014
Epigenetic mechanisms participate in melanoma development and progression. The effect of histone modifications and their catalyzing enzymes over euchromatic promoter DNA methylation in melanoma remains unclear. The present study investigated the potential association of p16(INK) (4A) promoter methylation with histone methyltransferase SETDB1 expression in Greek patients with sporadic melanoma and ...
Miao Qin Q Department of Geriatrics, Second Xiangya Hospital of Central South University, No. 139, Middle Renmin Road, Changsha, 410011, Hunan, People's Republic of - - 2014
The objective of this study is to detect the p66shc mRNA and protein expression of the peripheral blood monocytes (PBMs) in coronary heart disease patients (CHD) and controls, to evaluate the correlation between the expression of p66shc mRNA in the PBMs and endothelium-dependent vasodilatation. This study included 78 coronary angiography-documented ...
Rishmawi Louai L 1 Botanical Institute, University of - - 2014
In Arabidopsis thaliana, root hairs are formed in cell files over the cleft of underlying cortex cells. This pattern is established by a well-known gene regulatory network of transcription factors. In this study, we show that WRKY75 suppresses root hair development in non-root hair files and that it represses the ...
Fukazawa Elza M EM Department of Gynecologic Oncology (E.M.F., G.B., L.Y.K., C.C.F., L.B.-F.) Department of Pathology (F.A.S.), AC Camargo Cancer Hospital Department of Gynecologic Oncology (F.R.G.C., R.L.R.C., J.C.S.G.), Brazilian Institute of Cancer Control Discipline of Gynecologic Oncology Department of Obstetrics and Gynecology (W.J.G.), Federal University of Sao Paulo, Sao Paulo, - - 2014
We hypothesized that the activation of cyclooxygenase (COX)-2, epidermal growth factor receptor (EGFR), and ErbB-2 signaling is required for cervical intraepithelial neoplasia (CIN) lesions to progress to cervical cancer. A retrospective analysis was performed in 179 patients with Stage I squamous cell carcinoma (SCC) and 233 patients with CIN (112 ...
Kehlen Astrid A Institute of Physiological Chemistry, Martin Luther University of Halle-Wittenberg, Halle, - - 2014
Chemokines are involved in both the negative and positive regulation of inflammatory processes, angiogenesis, and cancer/cancer stem cell proliferation as well as the chemoattraction of tumor cells to metastatic sites. The aim of this study was to measure the mRNA expression levels of three chemokines, CCL2, CCL7, and CX3CL1, in ...
Gassling Volker V Department of Oral and Maxillofacial Surgery, University Hospital of Schleswig-Holstein, Campus Kiel, Kiel, Germany. Electronic address: - - 2014
Cleft lip and palate (CLP) represent the most common congenital malformations of the midfacial region. Although these patients show differences in their facial appearance, we hypothesize that CLP-affected individuals do not show an alteration in their emotion regulation abilities compared to unaffected individuals. This is because of the strong biological ...
Nguyen Khue Vu KV Department of Medicine, Biochemical Genetics and Metabolism, The Mitochondrial and Metabolic Disease Center, School of Medicine, University of California, San Diego, Building CTF, Room C-103, 214 Dickinson Street, San Diego, CA 92103-8467, USA; Department of Pediatrics, University of California, San Diego, School of Medicine, San Diego, La Jolla, CA 92093, USA. Electronic address: - - 2014
Lesch-Nyhan syndrome (LNS) is a neurogenetic disorder of purine metabolism in which the enzyme, hypoxanthine-guanine phosphoribosyltransferase (HPRT) is defective. A major unsolved question is how the loss of HPRT enzyme function affects the brain to cause the neurobehavioural syndrome in LNS and its attenuated variants (LNVs). To address this issue, ...
Mutsaers Henricus A M HA Institut National de la Santé et de la Recherche Médicale, Unité 693, Faculté de Médecine Paris-Sud, Le Kremlin-Bicêtre, - - 2014
Context: Sotos syndrome is a rare genetic disorder with a distinct phenotypic spectrum including overgrowth and learning difficulties. Here we describe a new case of Sotos syndrome with a 5q35 microdeletion, affecting the fibroblast growth factor receptor 4 (FGFR4) gene, presenting with infantile hypercalcemia. Objective: We strived to elucidate the ...
Panzer Rüdiger R Department of Dermatology, University of Kiel, - - 2014
The aim of the study was to investigate the expression of Toll-like receptor (TLR) 2 and 4 on keratinocytes in atopic dermatitis, contact dermatitis, and psoriasis by PCR and by immunohistochemistry including confocal microscopy. Confocal microscopy revealed a granular intracellular expression pattern for TLR 2 and a homogenous intracellular expression ...
Ghazaryan Hovsep H Institute of Molecular Biology, National Academy of Sciences of the Republic of Armenia (NAS RA), 7 Hasratyan Street, 0014 Yerevan, Armenia; Laboratory of Immunogenomics and Immunoproteomics, Department of Pathological Physiology, Faculty of Medicine and Dentistry, Palacky University, 6 I.P. Pavlova Street, 77520 Olomouc, Czech Republic. Electronic address: - - 2014
Altered immune response, including low-grade inflammatory processes, is involved in the pathogenesis of schizophrenia, a chronic psychiatric disorder with complex etiology. Distinct gene variants of a number of pro-inflammatory and chemotactic cytokines together with their receptors associate with this disorder. Interleukin-2 receptor gamma (IL-2RG) represents an important signaling component of ...
Liu Liping L State Key Laboratory of Oncology in Southern China, Department of Experimental Research, Cancer Center, Sun Yat-sen University, , Guangzhou, Guangdong, - - 2014
Transducin (β)-like 1 X-linked receptor 1 (TBL1XR1) plays an important role in controlling the precisely regulated switch between gene repression and gene activation in transcriptional regulation. We investigated its biological function and clinical significance in esophageal squamous cell carcinoma (ESCC). Immunoblotting and immunochemistry were used to determine TBL1XR1 expression in ...
Wu Qian Q Department of Neurology, Xiangya Hospital, Central South University, 87 Xiang Ya Road, Changsha, Hunan, 410008, - - 2014
Nuclear distribution factor E homolog like 1 (NDEL1) plays an important role in mitosis, neuronal migration, and microtubule organization during brain development by binding to disrupted-in-schizophrenia-1 (DISC1) or lissencephaly (LIS1). Although some evidence has suggested that DISC1 expression is altered in epilepsy, few studies have reported the relationship between NDEL1 ...
Suda Hiroko H Department of transplantation and Pediatric Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjyo, Kumamoto-city, 860-8556, Japan, - - 2014
Biliary atresia (BA) patients may survive until adolescence after effective Kasai procedure (KP). If liver fibrosis progresses even after successful KP, liver transplantation (LTx) is inevitable. Elucidation of its cause and pathophysiology would open the possibility of treating these patients by non-invasive management. SOX9 is a transcription factor that regulates ...
Cartwright Alison A Institute of Science and Technology in Medicine, Keele University at Leopold Muller Arthritis Research Centre, RJAH Orthopaedic Hospital, Oswestry, Shropshire, United - - 2014
Chemokine receptors on leukocytes mediate the recruitment and accumulation of these cells within affected joints in chronic inflammatory diseases such as rheumatoid arthritis (RA). Identification of involved receptors offers potential for development of therapeutic interventions. The objective of this study was to investigate the expression of orphan receptor GPR15/BOB in ...
Joseph Laurie B LB Department of Pharmacology and Toxicology, Rutgers University, Piscataway, NJ, United States. Electronic address: - - 2014
Sulfur mustard (SM) is a bifunctional alkylating agent causing skin inflammation, edema and blistering. A hallmark of SM-induced toxicity is follicular and interfollicular epithelial damage. In the present studies we determined if SM-induced structural alterations in hair follicles and sebaceous glands were correlated with cell damage, inflammation and wound healing. ...
Chen Wenbiao W Second Clinical Medical College of Jinan University, Shenzhen People's Hospital, Shenzhen Guangdong Province, - - 2014
Abstract Objectives: Our aim in this study was to identify and examine the differential expression of microRNAs in patients with systemic lupus erythematosus (SLE). Methods: We employed high quality, high-throughput Solexa sequencing to clone and identify microRNAs in SLE patients and a control group. Results: From the sequencing data, we ...
Woodward E M EM The Maxwell H. Gluck Equine Research Center, Department of Veterinary Science, University of Kentucky, Lexington, KY, 40546-0099, - - 2014
Research has shown that 6 hours after breeding is a critical time during the uterine innate immune response, and the failure to respond appropriately will result in persistent breeding-induced endometritis (PBIE). This presents a potential opportunity to modulate the course of inflammation towards a timely resolution. The objective was to ...
Xiao Shan S Reproductive Medicine Center, First Affiliated Hospital of Sun Yat-Sen University, Guangdong, People's Republic of - - 2014
Context: Polycystic ovary syndrome (PCOS) is the most common cause of dysfunctional ovulation-affecting female fertility. A disintegrin and metalloproteinase with thrombospondin-like motifs (ADAMTS-1) is required for normal ovulation and subsequent fertilization, and the expression of ADAMTS-1 may be altered in PCOS granulosa cells (GCs)-reflecting abnormalities in ovulatory signaling. Objective: The ...
Li Shu S Department of Neurosurgery, Beijing Tiantan Hospital Affiliated to Capital Medical University, Beijing 100050, P.R. - - 2014
Brain arteriovenous malformation (bAVM) is currently one of the most common cerebral vascular diseases, which result in severe clinical outcomes. The Notch signaling pathway is involved in vasculogenesis and angiogenesis, as well as vascular remodeling and arteriovenous differentiation in multiple diseases. Although there are previous studies on the correlation between ...
Zhao Chun C State Key Laboratory of Reproductive Medicine, Nanjing Maternity and Child Health Care Hospital Affiliated to Nanjing Medical University, Nanjing, Jiangsu 210004, P.R. - - 2014
The placenta is thought to have a critical role in the pathogenesis of gestational diabetes mellitus (GDM), as GDM‑associated complications resolve following delivery. Placenta‑specific microRNAs (miRNAs) may contribute to the pathology of the development of GDM. The aim of the present study was to evaluate whether the placenta‑specific miR‑518d contributes ...
Brianezi G G Departamento de Patologia (TOXICAM), FMB-Unesp, Botucatu, SP, - - 2014
The pathogenesis of melasma and the role of keratinocytes in disease development and maintenance are not completely understood. Dermal abnormalities, the expression of inflammatory mediators, growth factors, epithelial expression of melanocortin and sexual hormones receptors suggest that not only melanocytes, but entire epidermal melanin unit is involved in melasma physiopathology. ...
Kerami Zohra Z Tytgat Institute for Liver and Intestinal Research, Academic Medical Center, Amsterdam, The Netherlands. Electronic address: - - 2014
The expression of interleukin (IL)-17 is upregulated in inflammatory bowel disease (IBD). Since fibroblasts are known to be responsive to IL-17, they may play a role in the modulation of inflammatory responses in IBD. Here, the effects of IL-17 on ileum and colon fibroblasts from Crohn's disease (CD) and ulcerative ...
Hyon Joon Young JY Department of Ophthalmology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, - - 2014
To investigate the effect of macrophage migration inhibitory factor (MIF) on corneal sensitivity after laser in situ keratomileusis (LASIK) surgery. New Zealand white rabbits were used in this study. A hinged corneal flap (160-µm thick) was created with a microkeratome, and -3.0 diopter excimer laser ablation was performed. Expressions of ...
Wang Linna L Department of Pathology, Second Hospital of Hebei Medical University, No 215, West Heping Rd, 050000, Shijiazhuang, Hebei, People's Republic of - - 2014
The aim of this study is to investigate the possible roles of runt-related transcription factor 3 (RUNX3) and β-catenin in the carcinogenesis of sporadic colorectal tubular adenomas. The expression of the RUNX3 and β-catenin proteins was evaluated by immunohistochemistry in 23 normal colorectal mucosa (NCM), 81 sporadic colorectal tubular adenomas ...
Xu Xue-Dong XD Eye Hospital, Nanjing Medical University, 138# Han-Zhong Road, Nanjing, 210029, - - 2014
Pathological neovascularization are the most prevalent causes of moderate or severe vision loss. Long non-coding RNAs (lncRNAs) have emerged as a novel class of regulatory molecules involved in numerous biological processes and complicated diseases. However, the role of lncRNAs in ocular neovascularization is still unclear. Here, we constructed a murine ...
Liu Xiaowen X Department of Gastric Cancer and Soft Tissue Sarcoma, Fudan University Shanghai Cancer Center, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, - - 2014
The aim of this study was to evaluate the expression of CD24, p21, p53, and c-myc in lesions of patients with Alpha-Fetoprotein (AFP)-producing gastric cancer and their correlation with clinicopathological features and prognosis. One hundred and four patients with AFP-producing gastric cancer were included into this study. The levels of ...
Pavlaki Konstantia K University of Crete School of Medicine, Department of Hematology, Heraklion, Crete, Greece ; - - 2014
It has been shown that bone marrow mesenchymal stem cells (MSCs) from patients with myelodysplastic syndromes (MDS) display defective proliferative potential. We have probed the impaired replicative capacity of culture-expanded MSCs in MDS patients (n=30) compared to healthy subjects (n=32) by studying senescence characteristics and gene expression associated with WNT/TGFB1 ...
Shin Heon-Sub HS Department of Oriental Medicinal Materials & Processing, College of Life Science, Kyung Hee University, 1 Seocheon-Dong, Yongin, 446-701, - - 2014
This study was conducted to confirm the possibility of using minor ginseng saponin F2 by oral administration on hair anagen induction effects. The signaling pathway and anagen induction effect of ginsenoside F2 were investigated and compared with finasteride on the effect of hair growth induction. The cell-based MTT assay results ...
Liu Ruijie R Department of Medicine/Nephrology, Mount Sinai School of Medicine, New York, - - 2014
Nuclear factor (NF)-κB and signal transducer and activator of transcription 3 (STAT3) play a critical role in diabetic nephropathy (DN). Sirtuin-1 (SIRT1) regulates transcriptional activation of target genes through protein deacetylation. Here, we determined the roles of Sirt1 and the effect of NF-κB (p65) and STAT3 acetylation in DN. We ...
Punsawad Chuchard - - 2014
Acute kidney injury (AKI) is one of the major complications of Plasmodium falciparum malaria, especially among non-immune adults. It has recently been revealed that activation of transcription factor nuclear factor kappa B (NF-kappaB) induces pro-inflammatory gene expression involved in the development of progressive renal inflammatory diseases. The aim of this ...
Al Bashir Samir - - 2014
Cysteine- rich secretory protein 3 (CRISP3) prognostic significance in prostate cancer (PCA) has generated mixed result. Herein, we investigated and independently validated CRISP3 expression in relation to ERG and PTEN genomic aberrations and clinical outcome. CRISP3 protein expression was examined by immunohistochemistry using a cohort of patients with localized PCA ...
Zhu Min M From the Neurocognitive Aging Section (MZ, EP, ELS, PRR), and Gene Expression and Genomics Unit (YZ, KGB), National Institutes of Health, National Institute on Aging, Intramural Research Program, Biomedical Research Center, Baltimore, Maryland; and Department of Physiology and Biophysics, Howard University College of Medicine, Washington, DC - - 2014
The detrimental effect of activation of the chemokine CCL4/MIP-1β on neuronal integrity in patients with HIV-associated dementia has directed attention to the potential role of CCL4 expression and regulation in Alzheimer disease. Here, we show that CCL4 mRNA and protein are overexpressed in the brains of APPswe/PS1ΔE9 (APP/PS1) double-transgenic mice, ...
Qiao Yun Y Department of Traditional Chinese Medicine, Qilu Hospital, Shandong University, Jinan, 250012, - - 2014
To investigate the mechanism of Panax notoginseng saponins (PNS), an effective component extracted from Panax notoginseng, on atherosclerotic plaque angiogenesis in atherosclerosis-prone apolipoprotein E-knockout (ApoE-KO) mice fed with high-fat, high-cholesterol diet. Twenty ApoE-KO mice were divided into two groups, the model group and the PNS group. Ten normal C57BL/6J mice ...
Lotfi Ranya A RA Department of Dermatology and Venereology, Ain Shams University, Cairo, - - 2014
Telomeres are DNA-protein complexes that cap chromosomal ends, promoting chromosome stability. Telomerase is a ribonucleoprotein complex with a direct telomere protective function. Telomere shortening represents lifetime exposure to oxidative stress and is negatively correlated with age, smoking, and mortality. Smoking increases oxidative DNA modification and thus may influence telomere dynamics ...
Garcia-Esparcia Paula P Institute of Neuropathology, Bellvitge University Hospital, - - 2014
Neuroinflammation is common in neurodegenerative diseases including Parkinson disease (PD), but the extent of the process and their regional differences are not fully documented. Expression of twenty-five mRNAs was assessed with TaqMan-PCR including members of the complement system (C1QL1, C1QTNF7, C3AR1), colony stimulating factors (CYBA, CST7, INPP5D, CSF1R and CSF3R), ...
Mrizak Ines I University of Burgundy, INSERM U866, Faculty of Life Sciences, Dijon, France. - - 2014
Gestational diabetes mellitus (GDM) is pathology of glucose intolerance during pregnancy. It is influenced by maternal hyperglycemia and insulinemia through placental circulation. The study was undertaken to investigate the implication of pro-inflammatory factors in the placenta of GDM women. Thirty GDM women have delivered macrosomic babies, and 30 healthy age-matched ...
Overstreet Jessica M JM Center for Cell Biology and Cancer Research, Albany Medical College, 47 New Scotland Avenue Albany, NY - - 2014
Transforming growth factor-β1 (TGF-β1) regulates the tissue response to injury and is the principal driver of excessive scarring leading to fibrosis and eventual organ failure. The TGF-β1 effectors SMAD3 and p53 are major contributors to disease progression. While SMAD3 is an established pro-fibrotic factor, the role of p53 in the ...
Imamura Yuko Y *Department of Pharmacology and †Department of Medical Pharmacology, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima, - - 2014
The hypoxia-inducible factors HIF-1α or HIF-2α form heterodimeric complexes with the aryl hydrocarbon receptor nuclear translocator (ARNT). HIF-1α/ARNT and HIF-2α/ARNT complexes activate hypoxia-inducible genes that play critical roles in angiogenesis, anaerobic metabolism, and other processes in response to O2 deprivation. HIF-2α is known to regulate the function and/or differentiation of ...
Abu-Humaidan Anas H A AH Division of Infection Medicine, Department of Clinical Sciences, Lund University, 221 84 Lund, - - 2014
The complement system is activated in response to tissue injury. During wound healing, complement activation seems beneficial in acute wounds but may be detrimental in chronic wounds. We found that the epidermal expression of many complement components was only increased to a minor extent in skin wounds in vivo and ...
Gao Yan-Xiang YX Department of Cardiology, China-Japan Friendship Hospital, Beijing, P. R. - - 2014
Background/Aims: We investigated the recently described family of proteinases, a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTs), and matrix metalloproteinases (MMPs) as inflammatory mediators in inflammatory kidney damage by studying ADAMTS-1, -4, and -7 and MMP-9 expression in elderly mouse kidneys after angiotensin II (Ang II) administration. Methods: Ang II ...
Martins F S FS Laboratory of Manipulation of Oocytes Enclosed in Preantral Follicles (LAMOFOPA), Veterinary Faculty, State University of Ceará, Fortaleza, - - 2014
This study aimed to demonstrate the expression of growth hormone receptor (GH-R) mRNA and protein in goat ovarian follicles in order to investigate the effects of GH on the survival and development of preantral follicles. The ovaries were processed for the isolation of follicles to study GH-R mRNA expression or ...
Chighizola Cb C University of Milan, Milan, - - 2014
Systemic sclerosis (SSc) is a chronic autoimmune disease characterised by excessive deposition of extracellular matrix (ECM) components, immune activation and neoangiogenesis. The pathogenesis of scleroderma is still poorly elucidated; however, an increasing burden of evidence suggests involvement of Toll-like Receptors (TLRs). In our working hypothesis, nucleic acid-containing immune complexes (ICs) ...
Pagano Sabrina S Division of Laboratory Medicine, Department of Genetics and Laboratory Medicine, Geneva University Hospitals, - - 2014
Autoimmune-mediated inflammation may play a role in atherosclerosis and atherothrombosis, essential features for cardiovascular disease (CVD) manifestations. Anti-Apolipoprotein A-1 (ApoA-1) IgG autoantibodies are an independent predictor of poor cardiovascular outcome in different clinical settings, promote inflammation and atherogenesis and are associated with increased atherosclerotic plaque vulnerability in humans and mice. ...
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