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Results 201 - 250 of 3163
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Hadžibegović Irzal I Internal Medicine Department, General Hospital "dr. Josip Benčević", Faculty of Medicine, University of Osijek, Andrije Štampara 42, 35000, Slavonski Brod, Croatia, - - 2014
Acute coronary syndrome (ACS) is caused by destabilization and rupture of atherosclerotic plaque in the coronary artery via mechanisms affecting leukocyte signaling, rolling, adhesion, extravasation and inflammation-promoting factors. The majority of cellular communication takes place on the membrane surface that is covered with glycoproteins and glycolipids synthesized by glycosyltransferases. The ...
Stober Vandy P VP 1National Institute of Environmental Health - - 2014
Epithelial injury is often detected in lung allografts however its relation to rejection pathogenesis is unknown. We hypothesized that sterile epithelial injury can lead to alloimmune activation in the lung. We performed adoptive transfer of mismatched splenocytes into recombinant activating gene 1 (Rag1) deficient mice to induce an alloimmune status, ...
Smith Ryan M RM Department of Pharmacology, OSU College of Medicine Center for Pharmacogenomics, The Ohio State University, Columbus, - - 2014
The serotonin 2A receptor gene (HTR2A) harbors two functional single nucleotide polymorphisms (SNPs) that are frequent in populations of African and European descent; rs6311, which affects mRNA expression, and rs6314, which changes the amino acid sequence of the encoded protein and affects the signaling properties of the receptor. Multiple clinical ...
Catts Vibeke Sørensen VS 1Schizophrenia Research Institute, Sydney, - - 2014
Objective:While schizophrenia may have a progressive component, the evidence for neurodegenerative processes as indicated by reactive astrocytes is inconclusive. We recently identified a subgroup of individuals with schizophrenia with increased expression of inflammatory markers in prefrontal cortex, and hypothesized that this subgroup would also have reactive astrocytes.Method:We measured glial fibrillary ...
Song Penghong P Key Laboratory of Combined Multi-organ Transplantation, Ministry of Public Health, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310003, - - 2014
Biliary tract obstruction is a common clinical lesion. However, the effect of biliary tract obstruction on intestinal secretion is poorly understood. In this study, we made an investigation on intestinal HCO3 (-) and Cl(-) secretions in an experimental model of murine biliary duct ligation. Murine intestinal mucosal HCO3 (-) and ...
Chen Rong R Department of Biochemistry and Molecular Biology, College of Basic Medicine,Key Laboratory of Medical Biotechnology of Hebei Province, Key Laboratory of Neural and Vascular Biology of Ministry of Education, Hebei Medical University, Shijiazhuang 050017, PR - - 2014
Smooth muscle cell marker, SM22α, was down-regulated in the pathogenesis of arterial diseases including atherosclerosis, restenosis and abdominal aortic aneurysms. However, the question still exists whether this down-regulation actively contributes to the pathogenesis of vascular diseases. In an ongoing effort to understand the role of SM22α, here we explored transcriptome ...
Song Jinsoo J Department of Biological Sciences, College of Natural Sciences, Wonkwang University, Iksan, Chunbuk, 570-749, - - 2014
Despite growing importance of long non-coding RNAs (lncRNAs) in normal physiological and disease conditions, our knowledge of RA-related lncRNAs remains limited. Therefore, we aimed to identify lncRNA signatures that have prognostic values in RA. There was a notably high expression level of Hotair in blood mononuclear cells and serum exosome ...
Skalska Urszula U Department of Pathophysiology and Immunology, Institute of Rheumatology, Warsaw, - - 2014
To evaluate the osteoblastic potential of adipose-derived mesenchymal stem cells (ASCs) from infrapatellar fat pad (IPFP) of rheumatoid arthritis (RA) patients in comparison to osteoarthritis (OA) patients, as well as the influence of tumor necrosis factor alpha (TNFα) on osteoblastic ASC differentiation in vitro. ASCs were isolated from IPFP of ...
Sonneveld Ramon R Department of Nephrology, Radboud University Medical Center, Nijmegen, The Netherlands; Department of Physiology, Radboud University Medical Center, Nijmegen, The - - 2014
Slit diaphragm and podocyte damage is crucial in proteinuria pathogenesis in diabetic nephropathy (DNP). Gain-of-function mutations in TRPC6, a slit diaphragm-associated ion channel, cause glomerulosclerosis; TRPC6 expression is increased in acquired glomerular disease. Hyperglycemia and high intrarenal angiotensin II (AngII) levels could contribute to podocyte injury in DNP. We determined ...
Haug A T AT Dept. of Trauma Surgery, Klinikum rechts der Isar, Technical University Munich, Ismaninger Straße 22, 81675, Munich, Germany, - - 2014
Diabetes mellitus type 2 (2DM) is associated with altered bone quality. In order to analyze associated changes on a molecular level, we investigated the gene expression of key factors of osteoblast metabolism in type 2 diabetics. Total mRNA and protein of bone samples from 2DM patients and non-diabetic patients were ...
Chung Hyeyoung A HA Department of Molecular and Cell Biology, University of California, Berkeley, CA - - 2014
A forward genetic screen of N-ethyl-N-nitrosourea mutagenized Xenopus tropicalis has identified an inner ear mutant named eclipse (ecl). Mutants developed enlarged otic vesicles and various defects of otoconia development; they also showed abnormal circular and inverted swimming patterns. Positional cloning identified specificity protein 8 (sp8), which was previously found to ...
Weidlich Simon S *Department of Pediatrics, Dr. von Hauner Children's Hospital †Department of Pediatric Surgery, Dr. von Hauner Children's Hospital ‡Institute of Pathology, Ludwig Maximilians University, Munich, - - 2014
The function of interleukin-37 is not resolved yet. We recently showed that IL-37 suppresses colonic inflammation in mice. To gain more insight into its relevance in human disease, we investigated the expression of IL-37 in the intestine of pediatric patients with chronic inflammatory bowel disease. Intestinal biopsies were obtained from ...
Hertel Johannes J Laboratory for Angiogenesis and Tumor Metastasis, Campus Mitte, Charité University Hospital Berlin, Charitéplatz 1, 10117, Berlin, - - 2014
In the past, the vascular endothelial growth factor receptor-3 (VEGFR-3) has been linked to the regulation of lymphangiogenesis and the lymphatic spread of solid malignancies. The molecular mechanisms controlling VEGFR3 gene expression have, however, remained poorly understood. Here, we aimed at assessing these mechanisms through VEGFR3 gene promoter analysis and ...
Hahn Rebecca T RT Department of Pharmacy, Pharmaceutical Biology, Saarland University, Saarbruecken, - - 2014
Glucocorticoid-induced leucine zipper (GILZ) represents an anti-inflammatory mediator, whose downregulation has been described in various inflammatory processes. Aim of our study was to decipher the regulation of GILZ in vascular inflammation. Degenerated aortocoronary saphenous vein bypass grafts (n = 15), which exhibited inflammatory cell activation as determined by enhanced monocyte chemoattractrant protein ...
Oren Yifat S YS Department of Genetics, The Hebrew University, Jerusalem, - - 2014
One-third of monogenic inherited diseases result from premature termination codons (PTCs). Readthrough of in-frame PTCs enables synthesis of full-length functional proteins. However, extended variability in the response to readthrough treatment is found among patients, which correlates with the level of nonsense transcripts. Here, we aimed to reveal cellular pathways affecting ...
Ibrahim Lamia L Hematology Unit, Clinical Pathology Department, Mansoura Faculty of Medicine, Mansoura, Egypt, - - 2014
Livin, a member of the inhibitor of apoptosis proteins has been considered to be a poor prognostic marker in malignancies. However, little is known about the clinical relevance of livin expression in childhood acute lymphoblastic leukemia (ALL). The aim of the present study was to assess the expression of livin ...
Viengchareun Say S Institut National de la Santé et de la Recherche Médicale, U693, Le Kremlin-Bicêtre, - - 2014
The mineralocorticoid receptor (MR) mediates the Na(+)-retaining action of aldosterone. MR is highly expressed in the distal nephron, which is submitted to intense variations in extracellular fluid tonicity generated by the corticopapillary gradient. We previously showed that post-transcriptional events control renal MR abundance. Here, we report that hypertonicity increases expression ...
Matsuda Mitsuhiro M Department of Dermatology, Kurume University School of Medicine, Kurume University Institute of Cutaneous Cell Biology, Kurume, - - 2014
Hailey-Hailey disease (HHD) is a dominantly inherited skin disease caused by mutations in ATP2C1 gene, which encodes secretory pathway Ca(2+) /Mn(2+) -ATPase protein 1. The precise mechanism remains unclear. In this study, to understand molecular basis of HHD, we examined expression of mRNA and protein in cultured keratinocytes derived from ...
Ferrandi M M Prassis sigma-tau Research Institute, Via Forlanini, 3, Settimo Milanese, Milan, - - 2014
Mutant α-adducin and endogenous ouabain (EO) levels exert a causal role in hypertension by affecting renal Na-K ATPase. In addition, mutant β-adducin is involved in glomerular damage through nephrin down-regulation. Recently, the salt-inducible kinase 1 (SIK1) has been shown to exert a permissive role on mutant α-adducin effects on renal ...
Syrjänen Leo L Institute of Biomedical Technology and School of Medicine, University of Tampere, Tampere, - - 2014
Purpose of the study was to evaluate the presence of hypoxia-inducible, tumour-associated carbonic anhydrases IX and XII in normal skin and a series of cutaneous tumours. Human tumour samples were taken during surgical operations performed on 245 patients and were immunohistochemically stained. A histological score value was calculated for statistical ...
Kunii Yasuto Y Department of Neuropsychiatry, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima, Fukushima 960-1295, Japan. Electronic address: - - 2014
Dopamine- and cAMP-regulated phosphoprotein of molecular weight 32kDa (DARPP-32) and calcineurin (CaN) have been implicated in the pathogenesis of schizophrenia because they function as molecular integrators of dopamine and glutamate signaling. DARPP-32 and CaN are mainly expressed in the caudate nucleus and putamen; however, a few postmortem brain studies have ...
Fang De-Ren DR Department of Dermatology, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China. Electronic address: - - 2014
To analyze the dynamic expression of Wnt family member 5A (Wingless-type MMTV integration Wnt site family, member 5a) in murine hair cycle and its inhibitory effects on follicle in vivo. Situ hybridization in full-thickness skin was used to observe the change of mouse protein expression in different growth stages, and ...
Farimani Sanoee Marzieh M Endometrium and Endometriosis Research Center, Hamadan University of Medical Sciences, Hamadan, Iran. - - 2014
Background: In fertile women, glycodelin and glutathione peroxidase 3 (GPx3) genes expression rises during the luteal phase, with a peak occurring during the implantation window. The expression of these genes decreases in women with myomas. To determine whether myomectomy would reverse glycodelin and GPx3 expression, we evaluated the transcript levels ...
Yamauchi Masumi M From the *Department of Surgery 1, School of Medicine, University of Occupational and Environmental Health, Yahata-nishi-ku; and †Department of Gastroenterological and General Surgery, Wakamatsu Hospital of University of Occupational and Environmental Health, Wakamatsu-ku, Kitakyushu, - - 2014
Mitochondrial transcription factor A (mtTFA) is mandatory for both the transcription and maintenance of mitochondrial DNA. This study aimed to investigate the significance of mtTFA expression in pancreatic ductal adenocarcinoma (PDAC). Surgical specimens from 93 patients with PDAC who all underwent pancreatectomy were immunohistochemically stained using a polyclonal anti-mtTFA antibody. ...
Lim Y Y YY Department of Dermatology, Chung-Ang University College of Medicine, Seoul, - - 2014
Vitamin D receptor (VDR) is expressed in dermal papilla cells and in the epidermis of the hair follicle. Patients with alopecia areata (AA) and alopecia universalis (AU) have VDR mutations. We investigated expression of VDR in isolated hair follicles and epidermal keratinocytes from patients with AA or AU, and assessed ...
Zhai Jiajie J Department of Pharmacology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, Guangdong 510040, P.R. - - 2014
The present study aimed to explore the feasibility of using antisense connexin (Cx) treatment to promote corneal wound healing, and to investigate the changes of Cx gap junction proteins in terms of mRNA, protein expression and distribution in human corneas that were diseased due to various causes. A total of ...
Li Qing Q Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China, - - 2014
The cytokines of acute leukemia (AL) patients have certain expression patterns, forming a complex network involved in diagnosis, progression, and prognosis. We collected the serum of different AL patients before and after complete remission (CR) for detection of cytokines by using an antibody chip. The expression patterns of cytokines were ...
Wang Wenyuan - - 2014
To explore the clinical significance of expression of CEA mRNA and serum CEA and the related proteins in colorectal cancer (CRC). Blood samples were collected from 370 CRC patients and 350 controls. CEA mRNA was determined by RT-PCR and levels of CEA, CA19-9, CA242, and CA724 were examined with chemiluminescence. ...
Chuanwu Zhu Z Department of Hepatology, The Affiliated Infectious Disease Hospital of Soochow University, Suzhou, - - 2014
Telomerase activity is closely associated with the expression of human telomerase reverse transcriptase (hTERT) mRNA; although it can be induced in hepatocytes during liver regeneration, its dynamic change in patients with liver failure has remained unclear. We investigated the variation and significance of hTERT mRNA expression in peripheral blood mononuclear ...
Kim Bongsu B Havener Eye Institute, Department of Ophthalmology and Visual Science, The Ohio State University, Columbus, Ohio, United - - 2014
Matrix metalloproteinases (MMPs) and their inhibitors play a role in the pathobiology of retinal detachment (RD) and proliferative vitreoretinopathy (PVR). Proliferative vitreoretinopathy is facilitated by chronic retinal detachment and involves excessive deposition of extracellular matrix (ECM) proteins. Matrix metalloproteinase-2 and -13 are important modulators of the ECM which have not ...
Osuka Koji K Aichi Medical University, Neurological Surgery, Nagakute, Aichi, Japan ; - - 2014
Chronic subdural hematoma (CSDH) is considered to be an inflammatory disease. Eosinophils are frequently expressed in the outer membrane of CSDH and are major sources of transforming growth factor-β (TGF-β). The Smad signaling pathway, which is activated by TGF-β, has been shown to be involved with fibrosis. In the present ...
Donati Giacomo G Centre for Stem Cells and Regenerative Medicine, Kings College London, London SE1 9RT, United - - 2014
It has long been recognized that the hair follicle growth cycle and oscillation in the thickness of the underlying adipocyte layer are synchronized. Although factors secreted by adipocytes are known to regulate the hair growth cycle, it is unclear whether the epidermis can regulate adipogenesis. We show that inhibition of ...
Kostaki Maria M Department of Biological Chemistry, University of Athens Medical School, 11527, Athens, - - 2014
Epigenetic mechanisms participate in melanoma development and progression. The effect of histone modifications and their catalyzing enzymes over euchromatic promoter DNA methylation in melanoma remains unclear. The present study investigated the potential association of p16(INK) (4A) promoter methylation with histone methyltransferase SETDB1 expression in Greek patients with sporadic melanoma and ...
Aqrawi Lara A LA Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway. - - 2014
Ro52 is an E3 ubiquitin ligase with a prominent regulatory role in inflammation. The protein is a common target of circulating autoantibodies in rheumatic autoimmune diseases, particularly Sjögren's syndrome (SS). In this study we aimed to investigate the expression of the SS target autoantigen Ro52 in salivary glands of patients ...
Miao Qin Q Department of Geriatrics, Second Xiangya Hospital of Central South University, No. 139, Middle Renmin Road, Changsha, 410011, Hunan, People's Republic of - - 2014
The objective of this study is to detect the p66shc mRNA and protein expression of the peripheral blood monocytes (PBMs) in coronary heart disease patients (CHD) and controls, to evaluate the correlation between the expression of p66shc mRNA in the PBMs and endothelium-dependent vasodilatation. This study included 78 coronary angiography-documented ...
Kehlen Astrid A Institute of Physiological Chemistry, Martin Luther University of Halle-Wittenberg, Halle, - - 2014
Chemokines are involved in both the negative and positive regulation of inflammatory processes, angiogenesis, and cancer/cancer stem cell proliferation as well as the chemoattraction of tumor cells to metastatic sites. The aim of this study was to measure the mRNA expression levels of three chemokines, CCL2, CCL7, and CX3CL1, in ...
Rishmawi Louai L 1 Botanical Institute, University of - - 2014
In Arabidopsis thaliana, root hairs are formed in cell files over the cleft of underlying cortex cells. This pattern is established by a well-known gene regulatory network of transcription factors. In this study, we show that WRKY75 suppresses root hair development in non-root hair files and that it represses the ...
Fukazawa Elza M EM Department of Gynecologic Oncology (E.M.F., G.B., L.Y.K., C.C.F., L.B.-F.) Department of Pathology (F.A.S.), AC Camargo Cancer Hospital Department of Gynecologic Oncology (F.R.G.C., R.L.R.C., J.C.S.G.), Brazilian Institute of Cancer Control Discipline of Gynecologic Oncology Department of Obstetrics and Gynecology (W.J.G.), Federal University of Sao Paulo, Sao Paulo, - - 2014
We hypothesized that the activation of cyclooxygenase (COX)-2, epidermal growth factor receptor (EGFR), and ErbB-2 signaling is required for cervical intraepithelial neoplasia (CIN) lesions to progress to cervical cancer. A retrospective analysis was performed in 179 patients with Stage I squamous cell carcinoma (SCC) and 233 patients with CIN (112 ...
Nguyen Khue Vu KV Department of Medicine, Biochemical Genetics and Metabolism, The Mitochondrial and Metabolic Disease Center, School of Medicine, University of California, San Diego, Building CTF, Room C-103, 214 Dickinson Street, San Diego, CA 92103-8467, USA; Department of Pediatrics, University of California, San Diego, School of Medicine, San Diego, La Jolla, CA 92093, USA. Electronic address: - - 2014
Lesch-Nyhan syndrome (LNS) is a neurogenetic disorder of purine metabolism in which the enzyme, hypoxanthine-guanine phosphoribosyltransferase (HPRT) is defective. A major unsolved question is how the loss of HPRT enzyme function affects the brain to cause the neurobehavioural syndrome in LNS and its attenuated variants (LNVs). To address this issue, ...
Gassling Volker V Department of Oral and Maxillofacial Surgery, University Hospital of Schleswig-Holstein, Campus Kiel, Kiel, Germany. Electronic address: - - 2014
Cleft lip and palate (CLP) represent the most common congenital malformations of the midfacial region. Although these patients show differences in their facial appearance, we hypothesize that CLP-affected individuals do not show an alteration in their emotion regulation abilities compared to unaffected individuals. This is because of the strong biological ...
Mutsaers Henricus A M HA Institut National de la Santé et de la Recherche Médicale, Unité 693, Faculté de Médecine Paris-Sud, Le Kremlin-Bicêtre, - - 2014
Context: Sotos syndrome is a rare genetic disorder with a distinct phenotypic spectrum including overgrowth and learning difficulties. Here we describe a new case of Sotos syndrome with a 5q35 microdeletion, affecting the fibroblast growth factor receptor 4 (FGFR4) gene, presenting with infantile hypercalcemia. Objective: We strived to elucidate the ...
Panzer Rüdiger R Department of Dermatology, University of Kiel, - - 2014
The aim of the study was to investigate the expression of Toll-like receptor (TLR) 2 and 4 on keratinocytes in atopic dermatitis, contact dermatitis, and psoriasis by PCR and by immunohistochemistry including confocal microscopy. Confocal microscopy revealed a granular intracellular expression pattern for TLR 2 and a homogenous intracellular expression ...
Liu Liping L State Key Laboratory of Oncology in Southern China, Department of Experimental Research, Cancer Center, Sun Yat-sen University, , Guangzhou, Guangdong, - - 2014
Transducin (β)-like 1 X-linked receptor 1 (TBL1XR1) plays an important role in controlling the precisely regulated switch between gene repression and gene activation in transcriptional regulation. We investigated its biological function and clinical significance in esophageal squamous cell carcinoma (ESCC). Immunoblotting and immunochemistry were used to determine TBL1XR1 expression in ...
Wu Qian Q Department of Neurology, Xiangya Hospital, Central South University, 87 Xiang Ya Road, Changsha, Hunan, 410008, - - 2014
Nuclear distribution factor E homolog like 1 (NDEL1) plays an important role in mitosis, neuronal migration, and microtubule organization during brain development by binding to disrupted-in-schizophrenia-1 (DISC1) or lissencephaly (LIS1). Although some evidence has suggested that DISC1 expression is altered in epilepsy, few studies have reported the relationship between NDEL1 ...
Ghazaryan Hovsep H Institute of Molecular Biology, National Academy of Sciences of the Republic of Armenia (NAS RA), 7 Hasratyan Street, 0014 Yerevan, Armenia; Laboratory of Immunogenomics and Immunoproteomics, Department of Pathological Physiology, Faculty of Medicine and Dentistry, Palacky University, 6 I.P. Pavlova Street, 77520 Olomouc, Czech Republic. Electronic address: - - 2014
Altered immune response, including low-grade inflammatory processes, is involved in the pathogenesis of schizophrenia, a chronic psychiatric disorder with complex etiology. Distinct gene variants of a number of pro-inflammatory and chemotactic cytokines together with their receptors associate with this disorder. Interleukin-2 receptor gamma (IL-2RG) represents an important signaling component of ...
Suda Hiroko H Department of transplantation and Pediatric Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjyo, Kumamoto-city, 860-8556, Japan, - - 2014
Biliary atresia (BA) patients may survive until adolescence after effective Kasai procedure (KP). If liver fibrosis progresses even after successful KP, liver transplantation (LTx) is inevitable. Elucidation of its cause and pathophysiology would open the possibility of treating these patients by non-invasive management. SOX9 is a transcription factor that regulates ...
Cartwright Alison A Institute of Science and Technology in Medicine, Keele University at Leopold Muller Arthritis Research Centre, RJAH Orthopaedic Hospital, Oswestry, Shropshire, United - - 2014
Chemokine receptors on leukocytes mediate the recruitment and accumulation of these cells within affected joints in chronic inflammatory diseases such as rheumatoid arthritis (RA). Identification of involved receptors offers potential for development of therapeutic interventions. The objective of this study was to investigate the expression of orphan receptor GPR15/BOB in ...
Joseph Laurie B LB Department of Pharmacology and Toxicology, Rutgers University, Piscataway, NJ, United States. Electronic address: - - 2014
Sulfur mustard (SM) is a bifunctional alkylating agent causing skin inflammation, edema and blistering. A hallmark of SM-induced toxicity is follicular and interfollicular epithelial damage. In the present studies we determined if SM-induced structural alterations in hair follicles and sebaceous glands were correlated with cell damage, inflammation and wound healing. ...
Chen Wenbiao W Second Clinical Medical College of Jinan University, Shenzhen People's Hospital, Shenzhen Guangdong Province, - - 2014
Abstract Objectives: Our aim in this study was to identify and examine the differential expression of microRNAs in patients with systemic lupus erythematosus (SLE). Methods: We employed high quality, high-throughput Solexa sequencing to clone and identify microRNAs in SLE patients and a control group. Results: From the sequencing data, we ...
Woodward E M EM The Maxwell H. Gluck Equine Research Center, Department of Veterinary Science, University of Kentucky, Lexington, KY, 40546-0099, - - 2014
Research has shown that 6 hours after breeding is a critical time during the uterine innate immune response, and the failure to respond appropriately will result in persistent breeding-induced endometritis (PBIE). This presents a potential opportunity to modulate the course of inflammation towards a timely resolution. The objective was to ...
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