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Results 201 - 250 of 3202
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Xian-Jun Feng F Feng Xian-jun, Department of Respiratory Medicine, The First Affiliated Hospital of Xinxiang Medical University, Weihui, - - 2014
We conducted a perspective study to investigate the association between mRNA expression quantities of ERCC1, BRCA1, RRM1 and RRM2 and response to chemotherapy and clinical outcome of advance Non-Small Cell Lung Cancer.(NSCLC). Two hundred eight patients who were diagnosed as advanced stage NSCLC were included in our study. A fluorescence-based ...
Wang Lin - - 2014
Aims. To investigate the expression of CD44v3 and vascular endothelial growth factor C (VEGF-C) in gastric adenocarcinoma and the correlation with erythropoietin (EPO) and clinicopathological features. Methods. The expression of CD44v3, VEGF-C and EPO was evaluated by immunohistochemical staining in 169 gastric adenocarcinomas. The correlations between these parameters and patients' ...
Sohn Kyung-Cheol KC Department of Dermatology and Research Institute for Medical Sciences, School of Medicine, Chungnam National University, Daejeon, Republic of - - 2014
O-linked β-N-acetylglucosamine (O-GlcNAc) modification is one of the posttranslational modification, emerging as an important regulatory mechanism in various cellular events. We attempted to investigate whether O-GlcNAcylation is involved in keratinocyte differentiation. Immunohistochemistry and Western blot were performed to demonstrate O-GlcNAcylation in keratinocyte differentiation. During calcium-induced keratinocyte differentiation, overall O-GlcNAcylation was ...
Pesce M M Department of Psychological, Humanistic and Territorial Sciences, University "G. D'Annunzio", Chieti, - - 2014
Background: Recent lines of research have boosted awareness of the immunological facets of schizophrenia. However, associations with protein tyrosine phosphatase regulators have never been reported. The aim of our study was to investigate the expression and promoter status methylation of phosphatase SHP-1, a key negative regulator of the inflammatory process, ...
Yiş Uluç U 1School of Medicine, Department of Pediatrics, Division of Child Neurology, Dokuz Eylül University, İzmir, - - 2014
Subacute sclerosing panencephalitis is caused by persistent brain infection of mutated virus, showing inflammation, neurodegeneration, and demyelination. Although many factors are emphasized in the pathogenesis of subacute sclerosing panencephalitis, the exact mechanism of neurodegeneration remains unknown. Micro-RNAs are small, noncoding RNAs that regulate gene expression at the posttranscriptional levels. Micro-RNAs ...
Zhou Tian-Biao TB 1the Sixth Affiliated Hospital of Sun Yat-Sen - - 2014
LMX1B is a transcription factor of the LIM-homeodomain type and is implicated in the development of diverse structures such as limbs, kidneys, eyes and the brain. Furthermore, LMX1B has been implicated in nail-patella syndrome, which is predominantly characterized by malformation of limbs and nails, and in 30% of patients, nephropathy, ...
Li X L XL Department of Obstetrics & Gynaecology, First Affiliated Hospital of Xi'an Jiaotong University, China. Electronic address: - - 2014
Preeclampsia is a pregnancy-specific disorder and placental factor(s) contribute to the pathogenesis of preeclampsia. Turnover of villous trophoblast is affected by impaired placental perfusion in preeclampsia. Expression and localisation of cadherins and cytokeratins are involved in the pathogenesis of preeclampsia. However, studies describing the associations between cadherins and cytokeratins in ...
Mlitz Veronika V Department of Dermatology, Medical University of Vienna, Vienna, - - 2014
S100 fused-type proteins (SFTPs) such as filaggrin, trichohyalin and cornulin are differentially expressed in cornifying keratinocytes of the epidermis and various skin appendages. To determine evolutionarily conserved, and thus presumably important, features of SFTPs, we characterized non-mammalian SFTPs and compared their amino acid sequences and expression patterns to those of ...
Chen Yanxia - - 2014
This study is to investigate the role of miR-143 expression in cervical squamous cell carcinoma (SCC). The expression level of miR-143 was examined by quantitative real-time PCR. Human papillomavirus (HPV) genotype was detected by HPV genotype detection kit. The expression level of bcl-2 was detected by immunohistochemistry. The positive rate ...
Wang Huan H Renal Division, Department of Medicine, Peking University First Hospital; Institute of Nephrology, Peking University; Key Laboratory of Renal Disease, Ministry of Health of China; Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University), Ministry of Education; Beijing 100034, - - 2014
Increasing evidence suggested that toll-like receptors (TLRs) were critically involved in immune responses of ANCA-associated vasculitis (AAV). The current study aimed to investigate the expression of TLR2, TLR4, and TLR9 in kidneys of patients with ANCA-associated vasculitis. Renal biopsy specimens from 24 patients with AAV were collected. The expression of ...
Dong Wen W Department of Orthopaedic Surgery, Tianjin Hongqiao Hospital, Tianjin, PR - - 2014
Telomeres are specialized structures maintaining chromosome integrity during cellular division and preventing from premature senescence and apoptosis. The rate-limiting component of telomerase is human telomerase reverse transcriptase (hTERT), for which multiple transcripts exist. The aim of this work was to characterize hTERT splice variants in MDS and its relation to ...
Xia Fei - - 2014
The aim of the present study was to investigate the expression of glucose-related protein 78 (GRP78) and heparanase (HPA) in oral squamous cell carcinoma (OSCC) and their relationship with clinicopathological parameters and potential implications for survival. A total of 46 patients with OSCC and 10 normal individuals were recruited for ...
Denecker G G 1] Unit of Molecular and Cellular Oncology, Inflammation Research Center, VIB, 9052 Ghent, Belgium [2] Department of Biomedical Molecular Biology, Ghent University, 9052 Ghent, - - 2014
Deregulation of signaling pathways that control differentiation, expansion and migration of neural crest-derived melanoblasts during normal development contributes also to melanoma progression and metastasis. Although several epithelial-to-mesenchymal (EMT) transcription factors, such as zinc finger E-box binding protein 1 (ZEB1) and ZEB2, have been implicated in neural crest cell biology, little ...
Wrobel Tomasz T Department of Hematology, Blood Neoplasms and Bone Marrow Transplantation, Wroclaw Medical University, L. Pasteura 4 Street, 50-367, Wroclaw, - - 2014
Eph receptors represent the largest subfamily of receptor tyrosine kinases (RTKs). The up- regulation of Eph receptors has been documented in various solid tumors, where it often correlates with poor prognosis. Their significance in hematologic malignancies is still unclear. This study aimed to investigate the expression of Eph A4, Eph ...
Uemura Shuichiro S Department of Surgery, Institute of Gastroenterology, Tokyo Women's Medical University, Tokyo, - - 2014
No reliable biomarker for biliary tract cancer has yet been identified because of the varying composition of the cancer type, differences in tumor location, a mixture of curative and non-curative operations, and differences in operative methods. Fifty extrahepatic bile duct cancer patients, pathologically diagnosed with papillary or tubular adenocarcinoma who ...
Santos Juliana I JI Molecular Oncology Group, Portuguese Institute of Oncology of Porto, Rua Dr. António Bernardino de Almeida, Porto 4200-072, - - 2014
Prostate cancer (PC) is the more frequently diagnosed neoplasia in men in developed countries. The evolution of PC to castration-resistant prostate cancer (CRPC) represents real problems of clinical management, in consequence to the limited therapeutic options. MicroRNAs (miRNAs) are small noncoding RNAs that play an important role in gene expression ...
Lee Chan Gyu CG Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, - - 2014
The contribution of miRNA to the pathogenesis of acute kidney injury (AKI) is not well understood. Here we evaluated an integrative network of miRNAs and mRNA data to discover a possible master regulator of AKI. Microarray analyses of the kidneys of mice treated with cisplatin were used to extract putative ...
Ma Kun Ling - - 2014
Background: Our previous in-vivo and in-vitro studies demonstrated that inflammation accelerated the progression of atherosclerosis via the dysregulation of the low-density lipoprotein receptor (LDLr) pathway. The current study aimed to investigate the effects and their underlying mechanisms of inflammation on lipid accumulation in the radial arteries of endstage renal disease ...
Ye Qingqing Q Innovation Center China, AstraZeneca Global R&D, Shanghai, - - 2014
To investigate the expressions of key markers in the homologous recombination (HR) pathway and the correlation with clinicopathological parameters in serous ovarian cancer (SOC). We analyzed the protein expression of MRE11, MDC1, ATM, ATR and BRCA1 by immunohistochemistry (IHC) in 97 SOC samples, and correlated with clinical parameters including age, ...
Duong Francois H T FH Department of Biomedicine; and 2 Division of Gastroenterology and Hepatology, University Hospital Basel; University of Basel, 4031 Basel, - - 2014
The molecular mechanisms that link IFN-λ3 genotypes to differential induction of interferon (IFN)-stimulated genes (ISGs) in the liver of patients with chronic hepatitis C (CHC) are not known. We measured the expression of IFN-λ and of the specific IFN-λ receptor chain (IFN-λR1) in 122 liver biopsies of patients with CHC ...
Clairembault Thomas T Inserm, U913, Nantes, F-44093, France; University Nantes, Nantes, F-44093, France; CHU Nantes, Institut des Maladies de l'Appareil Digestif, Nantes, F-44093, - - 2014
Enteric glial cells (EGCs) are in many respects similar to astrocytes of the central nervous system and express similar proteins including glial fibrillary acidic protein (GFAP). Changes in GFAP expression and/or phosphorylation have been reported during brain damage or central nervous system degeneration. As in Parkinson's disease (PD) the enteric ...
Jimbo Keisuke K Department of Pediatrics and Adolescent Medicine, Juntendo University Graduate School of Medicine, Tokyo, - - 2014
Although pediatric inflammatory bowel disease (IBD) is characterized by extensive intestinal involvement and rapid early progression, the precise etiology and the specific factors involved in disease aggravation have not been well established. To investigate the pathogenesis of pediatric IBD. The expression of inflammatory molecules in colon samples taken from active ...
Prabowo A S AS 1Department of (Neuro)Pathology, Academic Medical Center, University of Amsterdam, The - - 2014
Recent evidence supports the activation of mechanisms underlying cellular ageing and neurodegeneration in developmental lesions associated with epilepsy. The present study examined the ongoing cell injury and vulnerability to neuronal degeneration in glioneuronal tumours (GNT). We evaluated a series of GNT (n= 31 gangliogliomas, GG and n= 30 dysembryoplastic neuroepithelial ...
Hadžibegović Irzal I Internal Medicine Department, General Hospital "dr. Josip Benčević", Faculty of Medicine, University of Osijek, Andrije Štampara 42, 35000, Slavonski Brod, Croatia, - - 2014
Acute coronary syndrome (ACS) is caused by destabilization and rupture of atherosclerotic plaque in the coronary artery via mechanisms affecting leukocyte signaling, rolling, adhesion, extravasation and inflammation-promoting factors. The majority of cellular communication takes place on the membrane surface that is covered with glycoproteins and glycolipids synthesized by glycosyltransferases. The ...
Stober Vandy P VP 1National Institute of Environmental Health - - 2014
Epithelial injury is often detected in lung allografts however its relation to rejection pathogenesis is unknown. We hypothesized that sterile epithelial injury can lead to alloimmune activation in the lung. We performed adoptive transfer of mismatched splenocytes into recombinant activating gene 1 (Rag1) deficient mice to induce an alloimmune status, ...
Smith Ryan M RM Department of Pharmacology, OSU College of Medicine Center for Pharmacogenomics, The Ohio State University, Columbus, - - 2014
The serotonin 2A receptor gene (HTR2A) harbors two functional single nucleotide polymorphisms (SNPs) that are frequent in populations of African and European descent; rs6311, which affects mRNA expression, and rs6314, which changes the amino acid sequence of the encoded protein and affects the signaling properties of the receptor. Multiple clinical ...
Catts Vibeke Sørensen VS 1Schizophrenia Research Institute, Sydney, - - 2014
Objective:While schizophrenia may have a progressive component, the evidence for neurodegenerative processes as indicated by reactive astrocytes is inconclusive. We recently identified a subgroup of individuals with schizophrenia with increased expression of inflammatory markers in prefrontal cortex, and hypothesized that this subgroup would also have reactive astrocytes.Method:We measured glial fibrillary ...
Song Penghong P Key Laboratory of Combined Multi-organ Transplantation, Ministry of Public Health, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310003, - - 2014
Biliary tract obstruction is a common clinical lesion. However, the effect of biliary tract obstruction on intestinal secretion is poorly understood. In this study, we made an investigation on intestinal HCO3 (-) and Cl(-) secretions in an experimental model of murine biliary duct ligation. Murine intestinal mucosal HCO3 (-) and ...
Chen Rong R Department of Biochemistry and Molecular Biology, College of Basic Medicine,Key Laboratory of Medical Biotechnology of Hebei Province, Key Laboratory of Neural and Vascular Biology of Ministry of Education, Hebei Medical University, Shijiazhuang 050017, PR - - 2014
Smooth muscle cell marker, SM22α, was down-regulated in the pathogenesis of arterial diseases including atherosclerosis, restenosis and abdominal aortic aneurysms. However, the question still exists whether this down-regulation actively contributes to the pathogenesis of vascular diseases. In an ongoing effort to understand the role of SM22α, here we explored transcriptome ...
Sonneveld Ramon R Department of Nephrology, Radboud University Medical Center, Nijmegen, The Netherlands; Department of Physiology, Radboud University Medical Center, Nijmegen, The - - 2014
Slit diaphragm and podocyte damage is crucial in proteinuria pathogenesis in diabetic nephropathy (DNP). Gain-of-function mutations in TRPC6, a slit diaphragm-associated ion channel, cause glomerulosclerosis; TRPC6 expression is increased in acquired glomerular disease. Hyperglycemia and high intrarenal angiotensin II (AngII) levels could contribute to podocyte injury in DNP. We determined ...
Song Jinsoo J Department of Biological Sciences, College of Natural Sciences, Wonkwang University, Iksan, Chunbuk, 570-749, - - 2014
Despite growing importance of long non-coding RNAs (lncRNAs) in normal physiological and disease conditions, our knowledge of RA-related lncRNAs remains limited. Therefore, we aimed to identify lncRNA signatures that have prognostic values in RA. There was a notably high expression level of Hotair in blood mononuclear cells and serum exosome ...
Skalska Urszula U Department of Pathophysiology and Immunology, Institute of Rheumatology, Warsaw, - - 2014
To evaluate the osteoblastic potential of adipose-derived mesenchymal stem cells (ASCs) from infrapatellar fat pad (IPFP) of rheumatoid arthritis (RA) patients in comparison to osteoarthritis (OA) patients, as well as the influence of tumor necrosis factor alpha (TNFα) on osteoblastic ASC differentiation in vitro. ASCs were isolated from IPFP of ...
Chung Hyeyoung A HA Department of Molecular and Cell Biology, University of California, Berkeley, CA - - 2014
A forward genetic screen of N-ethyl-N-nitrosourea mutagenized Xenopus tropicalis has identified an inner ear mutant named eclipse (ecl). Mutants developed enlarged otic vesicles and various defects of otoconia development; they also showed abnormal circular and inverted swimming patterns. Positional cloning identified specificity protein 8 (sp8), which was previously found to ...
Weidlich Simon S *Department of Pediatrics, Dr. von Hauner Children's Hospital †Department of Pediatric Surgery, Dr. von Hauner Children's Hospital ‡Institute of Pathology, Ludwig Maximilians University, Munich, - - 2014
The function of interleukin-37 is not resolved yet. We recently showed that IL-37 suppresses colonic inflammation in mice. To gain more insight into its relevance in human disease, we investigated the expression of IL-37 in the intestine of pediatric patients with chronic inflammatory bowel disease. Intestinal biopsies were obtained from ...
Haug A T AT Dept. of Trauma Surgery, Klinikum rechts der Isar, Technical University Munich, Ismaninger Straße 22, 81675, Munich, Germany, - - 2014
Diabetes mellitus type 2 (2DM) is associated with altered bone quality. In order to analyze associated changes on a molecular level, we investigated the gene expression of key factors of osteoblast metabolism in type 2 diabetics. Total mRNA and protein of bone samples from 2DM patients and non-diabetic patients were ...
Hertel Johannes J Laboratory for Angiogenesis and Tumor Metastasis, Campus Mitte, Charité University Hospital Berlin, Charitéplatz 1, 10117, Berlin, - - 2014
In the past, the vascular endothelial growth factor receptor-3 (VEGFR-3) has been linked to the regulation of lymphangiogenesis and the lymphatic spread of solid malignancies. The molecular mechanisms controlling VEGFR3 gene expression have, however, remained poorly understood. Here, we aimed at assessing these mechanisms through VEGFR3 gene promoter analysis and ...
Hahn Rebecca T RT Department of Pharmacy, Pharmaceutical Biology, Saarland University, Saarbruecken, - - 2014
Glucocorticoid-induced leucine zipper (GILZ) represents an anti-inflammatory mediator, whose downregulation has been described in various inflammatory processes. Aim of our study was to decipher the regulation of GILZ in vascular inflammation. Degenerated aortocoronary saphenous vein bypass grafts (n = 15), which exhibited inflammatory cell activation as determined by enhanced monocyte chemoattractrant protein ...
Oren Yifat S YS Department of Genetics, The Hebrew University, Jerusalem, - - 2014
One-third of monogenic inherited diseases result from premature termination codons (PTCs). Readthrough of in-frame PTCs enables synthesis of full-length functional proteins. However, extended variability in the response to readthrough treatment is found among patients, which correlates with the level of nonsense transcripts. Here, we aimed to reveal cellular pathways affecting ...
Matsuda Mitsuhiro M Department of Dermatology, Kurume University School of Medicine, Kurume University Institute of Cutaneous Cell Biology, Kurume, - - 2014
Hailey-Hailey disease (HHD) is a dominantly inherited skin disease caused by mutations in ATP2C1 gene, which encodes secretory pathway Ca(2+) /Mn(2+) -ATPase protein 1. The precise mechanism remains unclear. In this study, to understand molecular basis of HHD, we examined expression of mRNA and protein in cultured keratinocytes derived from ...
Syrjänen Leo L Institute of Biomedical Technology and School of Medicine, University of Tampere, Tampere, - - 2014
Purpose of the study was to evaluate the presence of hypoxia-inducible, tumour-associated carbonic anhydrases IX and XII in normal skin and a series of cutaneous tumours. Human tumour samples were taken during surgical operations performed on 245 patients and were immunohistochemically stained. A histological score value was calculated for statistical ...
Ferrandi M M Prassis sigma-tau Research Institute, Via Forlanini, 3, Settimo Milanese, Milan, - - 2014
Mutant α-adducin and endogenous ouabain (EO) levels exert a causal role in hypertension by affecting renal Na-K ATPase. In addition, mutant β-adducin is involved in glomerular damage through nephrin down-regulation. Recently, the salt-inducible kinase 1 (SIK1) has been shown to exert a permissive role on mutant α-adducin effects on renal ...
Viengchareun Say S Institut National de la Santé et de la Recherche Médicale, U693, Le Kremlin-Bicêtre, - - 2014
The mineralocorticoid receptor (MR) mediates the Na(+)-retaining action of aldosterone. MR is highly expressed in the distal nephron, which is submitted to intense variations in extracellular fluid tonicity generated by the corticopapillary gradient. We previously showed that post-transcriptional events control renal MR abundance. Here, we report that hypertonicity increases expression ...
Kunii Yasuto Y Department of Neuropsychiatry, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima, Fukushima 960-1295, Japan. Electronic address: - - 2014
Dopamine- and cAMP-regulated phosphoprotein of molecular weight 32kDa (DARPP-32) and calcineurin (CaN) have been implicated in the pathogenesis of schizophrenia because they function as molecular integrators of dopamine and glutamate signaling. DARPP-32 and CaN are mainly expressed in the caudate nucleus and putamen; however, a few postmortem brain studies have ...
Ibrahim Lamia L Hematology Unit, Clinical Pathology Department, Mansoura Faculty of Medicine, Mansoura, Egypt, - - 2014
Livin, a member of the inhibitor of apoptosis proteins has been considered to be a poor prognostic marker in malignancies. However, little is known about the clinical relevance of livin expression in childhood acute lymphoblastic leukemia (ALL). The aim of the present study was to assess the expression of livin ...
Yamauchi Masumi M From the *Department of Surgery 1, School of Medicine, University of Occupational and Environmental Health, Yahata-nishi-ku; and †Department of Gastroenterological and General Surgery, Wakamatsu Hospital of University of Occupational and Environmental Health, Wakamatsu-ku, Kitakyushu, - - 2014
Mitochondrial transcription factor A (mtTFA) is mandatory for both the transcription and maintenance of mitochondrial DNA. This study aimed to investigate the significance of mtTFA expression in pancreatic ductal adenocarcinoma (PDAC). Surgical specimens from 93 patients with PDAC who all underwent pancreatectomy were immunohistochemically stained using a polyclonal anti-mtTFA antibody. ...
Kim Bongsu B Havener Eye Institute, Department of Ophthalmology and Visual Science, The Ohio State University, Columbus, Ohio, United - - 2014
Matrix metalloproteinases (MMPs) and their inhibitors play a role in the pathobiology of retinal detachment (RD) and proliferative vitreoretinopathy (PVR). Proliferative vitreoretinopathy is facilitated by chronic retinal detachment and involves excessive deposition of extracellular matrix (ECM) proteins. Matrix metalloproteinase-2 and -13 are important modulators of the ECM which have not ...
Wang Wenyuan - - 2014
To explore the clinical significance of expression of CEA mRNA and serum CEA and the related proteins in colorectal cancer (CRC). Blood samples were collected from 370 CRC patients and 350 controls. CEA mRNA was determined by RT-PCR and levels of CEA, CA19-9, CA242, and CA724 were examined with chemiluminescence. ...
Lim Y Y YY Department of Dermatology, Chung-Ang University College of Medicine, Seoul, - - 2014
Vitamin D receptor (VDR) is expressed in dermal papilla cells and in the epidermis of the hair follicle. Patients with alopecia areata (AA) and alopecia universalis (AU) have VDR mutations. We investigated expression of VDR in isolated hair follicles and epidermal keratinocytes from patients with AA or AU, and assessed ...
Li Qing Q Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China, - - 2014
The cytokines of acute leukemia (AL) patients have certain expression patterns, forming a complex network involved in diagnosis, progression, and prognosis. We collected the serum of different AL patients before and after complete remission (CR) for detection of cytokines by using an antibody chip. The expression patterns of cytokines were ...
Jiang Xiaoyu X Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, Michigan, United - - 2014
To determine whether rapamycin altered corneal growth factor levels to impact severity of Pseudomonas aeruginosa keratitis. BALB/c mice were injected intraperitoneally with rapamycin or PBS and infected with P. aeruginosa. Corneas were harvested and mRNA levels of growth factors (EGF, HGF, FGF-7/KGF), receptors (EGFR, c-met, FGFR-2), and signaling molecules (PI3K, ...
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