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Cao Shiyi S School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of - - 2014
To investigate the relationship of protein expression of hypoxia-inducible factor-1 alpha (HIF-1α) with clinicopathological factors and prognosis of hepatocellular carcinoma (HCC). PubMed and Embase were searched from their inception through August 2013 for studies that reported the association between protein expression of HIF-1α and HCC. Random effects meta-analyses were used ...
Burek Malgorzata M University of Wurzburg, Department of Anaesthesia and Critical Care, Würzburg, Germany.. Electronic address: - - 2014
Claudin-5 is an integral membrane protein and a critical component of endothelial tight junctions that control paracellular permeability. Claudin-5 is expressed at high levels in the brain vascular endothelium. Estrogens have multiple effects on vascular physiology and function. The biological actions of estrogens are mediated by two different estrogen receptor ...
Heidary Masoumeh M Department of Basic Sciences, Gonabad University of Medical Sciences, Gonabad, Islamic Republic of - - 2014
IL-1B is released by monocytes, astrocytes and brain endothelial cells and seems to be involved in inflammatory reactions of the central nervous system (CNS) in multiple sclerosis (MS). This study aims to evaluate the expression level of IL-1B mRNA in peripheral blood mononuclear cells (PBMCs), genotype the rs16944 SNP and ...
Maeda Shingo S Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of - - 2014
Serine proteases elicit cellular responses via protease-activated receptor-2 (PAR-2) which is known to regulate inflammation and the immune response. Although the gastrointestinal tract is exposed to large amounts of proteolytic enzymes, the role of PAR-2 in canine inflammatory bowel disease (IBD) remains unclear. The objective of this study was to ...
Su Guangsong - - 2014
Abstract Ecotropic viral integration site-1 (EVI1) proto-oncogene expression in patients with acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) requires further investigation. Here, EVI1 expression levels were measured in 216 Chinese patients with AML and 67 with ALL via quantitative real-time PCR. We found that EVI1 expressed at a ...
Liu Chen-Geng CG Clinical Laboratory of Xuanwu Hospital, Capital Medical University, Beijing 100053, P.R. - - 2014
Amyloid precursor protein (APP) and β-site APP cleaving enzyme (BACE-1) play important roles in the pathogenesis of Alzheimer's disease (AD). In this study, using bioinformatics analysis, we demonstrate that miR-384 is a microRNA (miRNA or miR) predicted to potentially target the 3' untranslated regions (3'-UTRs) of both APP and BACE-1. SH-SY5Y ...
Chen Wenli W Faculty of Environmental Science and Engineering, Kunming University of Science and Technology, Kunming 650500, China; Medical Faculty, Kunming University of Science and Technology, Kunming 650500, China; Neurology Department, First People's Hospital of Yunnan Province, Kunming 650032, - - 2014
Myasthenia gravis (MG) is an autoimmune disease caused by circulating antibodies that block acetylcholine receptor (AchR) at the neuromuscular junction. There is the cognitive and memory impairment in patients with MG. However, the molecular mechanisms underlying the alteration of central nervous system in MG remain unknown. In the present study, ...
Fontseré Néstor N Department of - - 2014
Mortality and morbidity are significantly higher among patients with dialysis catheters, which has been associated with chronic activation of the immune system. We hypothesized that bacteria colonizing the catheter lumen trigger an inflammatory response. We aimed to evaluate the inflammatory profile of hemodialysis patients before and after locking catheters with ...
He Hui H College of Animal Science and Technology, Sichuan Agricultural University, Ya'an 625014, Sichuan Province, - - 2014
The ornithine decarboxylase antizyme 2 (OAZ2) gene is a member of the antizyme gene family. Antizymes play pivotal roles in various cellular pathways, including polyamine anabolism and apoptosis. The molecular structure and expression profile of the OAZ2 in goose ovarian follicles have not been reported. In this study, the OAZ2 ...
Jing Jing J Zhejiang University School of Medicine, Dermatology, Second Affiliated Hospital, Hangzhou, - - 2014
Decorin is a prototypical member of the small leucine-rich proteoglycan (SLRP) family, which is involved in numerous biological processes. The role of decorin, as a representative SLRP, in hair follicle morphogenesis has not been elucidated. We present our initial findings on decorin expression patterns during induced murine HF cycles. It ...
Sun Shiren S Department of Nephrology, Xijing Hospital, Fourth Military Medical University, Xi'an, - - 2014
Background: Chronic hypoxia-induced epithelial-to-mesenchymal transition (EMT) is a crucial process in renal fibrogenesis. Egr-1, as a transcription factor, has been proven to be important in promoting EMT. However, whether it functions in hypoxia-induced renal tubular EMT has not been fully elucidated. Methods: Egr-1 were detected at mRNA and protein levels ...
Chen Neal X NX Divison of Nephrology, Indiana University School of Medicine, Indianapolis, IN, USA. Electronic address: - - 2014
Calcification can occur in fat in multiple clinical conditions including in the dermis, breasts and in the abdomen in calciphylaxis. All of these are more common in patients with advanced kidney disease. Clinically, hyperphosphatemia and obesity are risk factors. Thus we tested the hypothesis that adipocytes can calcify in the ...
Galdino Hélio H - - 2014
The interleukin 32 (IL-32) is a proinflammatory cytokine produced by immune and non-immune cells. It can be induced during bacterial and viral infections, but its production was never investigated in protozoan infections. American Tegumentary Leishmaniasis (ATL) is caused by Leishmania protozoan leading to cutaneous, nasal or oral lesions. The aim ...
Makino Teruhiko T Department of Dermatology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Sugitani, Toyama 930-0194 Japan. Electronic address: - - 2014
Filaggrin-2 is a member of the S100 fused-type protein family, and the structural features and expression of filaggrin-2 are similar to those of profilaggrin, a protein essential for keratinization. In the present study, we investigated the expression profile of filaggrin-2 in patients with skin diseases using antibodies against the repetitive ...
Kohno Mikihiro M Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu - - 2014
Lung adenocarcinomas among never-smokers are more common in females than in males; this implies that gender-dependent hormones promote smoking-unrelated lung adenocarcinoma. We therefore investigated mRNA expression of aromatase, an intrinsic estrogen synthetase, in lung adenocarcinoma and assessed its correlation to clinicopathological factors, including EGFR mutations and post-surgical prognosis. Aromatase mRNA ...
Freise Christian C Department of Pediatric Nephrology and Center for Cardiovascular Research, Charité - University Medicine, Campus Virchow Clinic, Berlin, Germany. Electronic address: - - 2014
Vascular calcifications are a hallmark of advanced cardiovascular disease in patients with chronic kidney disease. A key event is the transition of contractile vascular smooth muscle cells (VSMC) into an osteoblast-like phenotype, promoting a coordinated process of vascular remodelling resembling bone mineralization. Intermediate-conductance calcium-activated potassium channels (KCa3.1) are expressed in ...
Logadottir Yr Y Department of Urology, Institute of Clinical Sciences, the Sahlgrenska Academy at the University of Gothenburg, Gothenburg, - - 2014
Nitric oxide (NO) production from the bladder wall in patients with Bladder Pain Syndrome (BPS) Type 3C is increased compared to undetectable NO levels in non-Hunner BPS patients and healthy controls. However, the underlying mechanism/s of the increased NO production is largely unknown. Our aim was to compare mRNA expression ...
Shalia Kavita K Sir H. N. Medical Research Society, Sir H. N. Hospital and Research Centre, Mumbai, - - 2014
ATP binding cassette transporter-A1 (ABCA1) facilitates the formation of high density lipoprotein (HDL). HDL due to its anti-atherosclerotic, anti-inflammatory and anti-thrombotic activities provides protection against atherothrombosis or myocardial infarction (MI). The aim was to investigate the role of peripheral blood mononuclear cell (PBMNC) ABCA1 expression in MI. The participants comprised ...
Yang Minglan M Department of Endocrine and Metabolic diseases, Ruijin Hospital, Shanghai JiaoTong University, School of Medicine, Shanghai Key Laboratory for Endocrine Tumors, Shanghai Clinical Center for Endocrine and Metabolic Diseases, 197 Ruijin 2nd Road, Shanghai 200025, P.R., - - 2014
Type 1 diabetes mellitus (T1D) is a common autoimmune disease mediated by autoimmune attack against pancreatic β cells. It has been reported that dysregulation of microRNAs (miRNAs) may contribute to the pathogenesis of autoimmune diseases, including T1D. This study sought to identify pathogenic miRNAs in peripheral blood mononuclear cell (PBMC) ...
Benderro Girriso F GF Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, - - 2014
Dynamic microvascular remodeling maintains an optimal continuous supply of oxygen and nutrients to the brain to account for prolonged environmental variations. The objective of this study was to determine the relative time course of capillary regression during re-oxygenation after exposure to prolonged moderate hypoxia and expression of the primary signaling ...
Kim Myung Gu MG Department of Otorhinolaryngology Head and Neck Surgery, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine , - - 2014
Abstract Conclusion: The increased expression of Dec-205, Bcl-10, Tim-3, and Trem-1 mRNAs indicates that these pattern recognition receptors are involved in the pathogenesis of cholesteatoma. Objective: Changes in expression of pattern recognition receptors may be associated with immune responses in patients with cholesteatoma. We therefore assessed the levels of expression ...
Zhou Xiaoqing X Department of Oral and Maxillofacial Surgery, First People's Hospital of Jining, Jining, Shandong 272111, P.R. - - 2014
Reversion-inducing cysteine-rich protein with Kazal motifs (RECK), a glycosylphosphatidylinositol-anchored glycoprotein, inhibits the enzymatic activities of certain matrix metalloproteinases (MMPs). RECK has been studied in numerous human tumors, but the expression of RECK in salivary adenoid cystic carcinoma (SACC), and its correlation with patient prognosis, has never been investigated thus far. ...
Cheng Tsu-Yao TY Laboratory of Molecular and Cellular Toxicology, Graduate Institute of Toxicology, College of Medicine, National Taiwan University, No. 1, Section 1, Jen Ai Road, Taipei 10051, Taiwan, R.O.C. - - 2014
Formyl peptide receptor 1 (FPR1) as a regulator of innate inflammatory response has been implicated in tumor progression of gliomas. The purpose of the present study was to evaluate the prognostic significance and the ligand-receptor interaction of FPR1 in gastric cancer (GC). FPR1 was immunohistochemically-analyzed in tissue sections originating from ...
Huang Chun-Huang CH From the Institute of Medicine, Department of Public Health, Chung Shan Medical University; Division of Allergy, Immunology and Rheumatology, Department of Family and Community Medicine, Chung Shan Medical University Hospital, Taichung; Department of Clinical Pharmacy, Taipei Medical University; Department of Pharmacy, Taipei Medical University-Wanfang Hospital, Taipei, - - 2014
Bone loss is a recognized feature of ankylosing spondylitis (AS). The binding of microRNA-21 (miR-21) to programmed cell death 4 (PDCD4) could inhibit the expression of PDCD4 and further induce the activation of osteoclasts. In the present study, we compared the difference in miR-21 expression between patients with AS and ...
Yu Y Y Department of Neurology, Peking University People's Hospital, Beijing, China. - - 2014
CD137 ligand (CD137L) is expressed by various immune cells and exists in membrane-bound and soluble forms. Recently, CD137L was found to be localized to macrophages in human atherosclerotic lesions and CD137L levels were much higher in atherosclerotic lesions than in normal arteries. However, the role of CD137L with different forms ...
Zhang Feng F Department of Dermatology, The First Affiliated Hospital of Harbin Medical University, Harbin, - - 2014
Caveolin-1 is a key structural and functional protein. Caveolin-1 is known to modulate multiple signal-transducing pathways involved in cell differentiation and proliferation. Psoriasis is viewed as a multifactorial pathology characterized by keratinocyte hyperproliferation and abnormal cell maturation. To examine the expression of caveolin-1 in skin biopsies from normal subjects, patients, ...
Woik Nicole N Heidelberg University, Mannheim, - - 2014
Respiratory distress syndrome (RDS) caused by preterm delivery is a major clinical problem with limited mechanistic insight. Late stage embryonic lung development is driven by hypoxia and hypoxia inducible transcription factors Hif-1α and Hif-2α, which act as important regulators for lung development. Expression of BTB-kelch protein KLEIP (Kelch-like ECT2 interacting ...
Wang Lin - - 2014
Aims. To investigate the expression of CD44v3 and vascular endothelial growth factor C (VEGF-C) in gastric adenocarcinoma and the correlation with erythropoietin (EPO) and clinicopathological features. Methods. The expression of CD44v3, VEGF-C and EPO was evaluated by immunohistochemical staining in 169 gastric adenocarcinomas. The correlations between these parameters and patients' ...
Xian-Jun Feng F Feng Xian-jun, Department of Respiratory Medicine, The First Affiliated Hospital of Xinxiang Medical University, Weihui, - - 2014
We conducted a perspective study to investigate the association between mRNA expression quantities of ERCC1, BRCA1, RRM1 and RRM2 and response to chemotherapy and clinical outcome of advance Non-Small Cell Lung Cancer.(NSCLC). Two hundred eight patients who were diagnosed as advanced stage NSCLC were included in our study. A fluorescence-based ...
Yiş Uluç U 1School of Medicine, Department of Pediatrics, Division of Child Neurology, Dokuz Eylül University, İzmir, - - 2014
Subacute sclerosing panencephalitis is caused by persistent brain infection of mutated virus, showing inflammation, neurodegeneration, and demyelination. Although many factors are emphasized in the pathogenesis of subacute sclerosing panencephalitis, the exact mechanism of neurodegeneration remains unknown. Micro-RNAs are small, noncoding RNAs that regulate gene expression at the posttranscriptional levels. Micro-RNAs ...
Zhou Tian-Biao TB 1the Sixth Affiliated Hospital of Sun Yat-Sen - - 2014
LMX1B is a transcription factor of the LIM-homeodomain type and is implicated in the development of diverse structures such as limbs, kidneys, eyes and the brain. Furthermore, LMX1B has been implicated in nail-patella syndrome, which is predominantly characterized by malformation of limbs and nails, and in 30% of patients, nephropathy, ...
Pesce M M Department of Psychological, Humanistic and Territorial Sciences, University "G. D'Annunzio", Chieti, - - 2014
Background: Recent lines of research have boosted awareness of the immunological facets of schizophrenia. However, associations with protein tyrosine phosphatase regulators have never been reported. The aim of our study was to investigate the expression and promoter status methylation of phosphatase SHP-1, a key negative regulator of the inflammatory process, ...
Sohn Kyung-Cheol KC Department of Dermatology and Research Institute for Medical Sciences, School of Medicine, Chungnam National University, Daejeon, Republic of - - 2014
O-linked β-N-acetylglucosamine (O-GlcNAc) modification is one of the posttranslational modification, emerging as an important regulatory mechanism in various cellular events. We attempted to investigate whether O-GlcNAcylation is involved in keratinocyte differentiation. Immunohistochemistry and Western blot were performed to demonstrate O-GlcNAcylation in keratinocyte differentiation. During calcium-induced keratinocyte differentiation, overall O-GlcNAcylation was ...
Li X L XL Department of Obstetrics & Gynaecology, First Affiliated Hospital of Xi'an Jiaotong University, China. Electronic address: - - 2014
Preeclampsia is a pregnancy-specific disorder and placental factor(s) contribute to the pathogenesis of preeclampsia. Turnover of villous trophoblast is affected by impaired placental perfusion in preeclampsia. Expression and localisation of cadherins and cytokeratins are involved in the pathogenesis of preeclampsia. However, studies describing the associations between cadherins and cytokeratins in ...
Mlitz Veronika V Department of Dermatology, Medical University of Vienna, Vienna, - - 2014
S100 fused-type proteins (SFTPs) such as filaggrin, trichohyalin and cornulin are differentially expressed in cornifying keratinocytes of the epidermis and various skin appendages. To determine evolutionarily conserved, and thus presumably important, features of SFTPs, we characterized non-mammalian SFTPs and compared their amino acid sequences and expression patterns to those of ...
Wang Huan H Renal Division, Department of Medicine, Peking University First Hospital; Institute of Nephrology, Peking University; Key Laboratory of Renal Disease, Ministry of Health of China; Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University), Ministry of Education; Beijing 100034, - - 2014
Increasing evidence suggested that toll-like receptors (TLRs) were critically involved in immune responses of ANCA-associated vasculitis (AAV). The current study aimed to investigate the expression of TLR2, TLR4, and TLR9 in kidneys of patients with ANCA-associated vasculitis. Renal biopsy specimens from 24 patients with AAV were collected. The expression of ...
Dong Wen W Department of Orthopaedic Surgery, Tianjin Hongqiao Hospital, Tianjin, PR - - 2014
Telomeres are specialized structures maintaining chromosome integrity during cellular division and preventing from premature senescence and apoptosis. The rate-limiting component of telomerase is human telomerase reverse transcriptase (hTERT), for which multiple transcripts exist. The aim of this work was to characterize hTERT splice variants in MDS and its relation to ...
Chen Yanxia - - 2014
This study is to investigate the role of miR-143 expression in cervical squamous cell carcinoma (SCC). The expression level of miR-143 was examined by quantitative real-time PCR. Human papillomavirus (HPV) genotype was detected by HPV genotype detection kit. The expression level of bcl-2 was detected by immunohistochemistry. The positive rate ...
Wrobel Tomasz T Department of Hematology, Blood Neoplasms and Bone Marrow Transplantation, Wroclaw Medical University, L. Pasteura 4 Street, 50-367, Wroclaw, - - 2014
Eph receptors represent the largest subfamily of receptor tyrosine kinases (RTKs). The up- regulation of Eph receptors has been documented in various solid tumors, where it often correlates with poor prognosis. Their significance in hematologic malignancies is still unclear. This study aimed to investigate the expression of Eph A4, Eph ...
Denecker G G 1] Unit of Molecular and Cellular Oncology, Inflammation Research Center, VIB, 9052 Ghent, Belgium [2] Department of Biomedical Molecular Biology, Ghent University, 9052 Ghent, - - 2014
Deregulation of signaling pathways that control differentiation, expansion and migration of neural crest-derived melanoblasts during normal development contributes also to melanoma progression and metastasis. Although several epithelial-to-mesenchymal (EMT) transcription factors, such as zinc finger E-box binding protein 1 (ZEB1) and ZEB2, have been implicated in neural crest cell biology, little ...
Xia Fei - - 2014
The aim of the present study was to investigate the expression of glucose-related protein 78 (GRP78) and heparanase (HPA) in oral squamous cell carcinoma (OSCC) and their relationship with clinicopathological parameters and potential implications for survival. A total of 46 patients with OSCC and 10 normal individuals were recruited for ...
Santos Juliana I JI Molecular Oncology Group, Portuguese Institute of Oncology of Porto, Rua Dr. António Bernardino de Almeida, Porto 4200-072, - - 2014
Prostate cancer (PC) is the more frequently diagnosed neoplasia in men in developed countries. The evolution of PC to castration-resistant prostate cancer (CRPC) represents real problems of clinical management, in consequence to the limited therapeutic options. MicroRNAs (miRNAs) are small noncoding RNAs that play an important role in gene expression ...
Uemura Shuichiro S Department of Surgery, Institute of Gastroenterology, Tokyo Women's Medical University, Tokyo, - - 2014
No reliable biomarker for biliary tract cancer has yet been identified because of the varying composition of the cancer type, differences in tumor location, a mixture of curative and non-curative operations, and differences in operative methods. Fifty extrahepatic bile duct cancer patients, pathologically diagnosed with papillary or tubular adenocarcinoma who ...
Lee Chan Gyu CG Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, - - 2014
The contribution of miRNA to the pathogenesis of acute kidney injury (AKI) is not well understood. Here we evaluated an integrative network of miRNAs and mRNA data to discover a possible master regulator of AKI. Microarray analyses of the kidneys of mice treated with cisplatin were used to extract putative ...
Ye Qingqing Q Innovation Center China, AstraZeneca Global R&D, Shanghai, - - 2014
To investigate the expressions of key markers in the homologous recombination (HR) pathway and the correlation with clinicopathological parameters in serous ovarian cancer (SOC). We analyzed the protein expression of MRE11, MDC1, ATM, ATR and BRCA1 by immunohistochemistry (IHC) in 97 SOC samples, and correlated with clinical parameters including age, ...
Ma Kun Ling - - 2014
Background: Our previous in-vivo and in-vitro studies demonstrated that inflammation accelerated the progression of atherosclerosis via the dysregulation of the low-density lipoprotein receptor (LDLr) pathway. The current study aimed to investigate the effects and their underlying mechanisms of inflammation on lipid accumulation in the radial arteries of endstage renal disease ...
Clairembault Thomas T Inserm, U913, Nantes, F-44093, France; University Nantes, Nantes, F-44093, France; CHU Nantes, Institut des Maladies de l'Appareil Digestif, Nantes, F-44093, - - 2014
Enteric glial cells (EGCs) are in many respects similar to astrocytes of the central nervous system and express similar proteins including glial fibrillary acidic protein (GFAP). Changes in GFAP expression and/or phosphorylation have been reported during brain damage or central nervous system degeneration. As in Parkinson's disease (PD) the enteric ...
Prabowo A S AS 1Department of (Neuro)Pathology, Academic Medical Center, University of Amsterdam, The - - 2014
Recent evidence supports the activation of mechanisms underlying cellular ageing and neurodegeneration in developmental lesions associated with epilepsy. The present study examined the ongoing cell injury and vulnerability to neuronal degeneration in glioneuronal tumours (GNT). We evaluated a series of GNT (n= 31 gangliogliomas, GG and n= 30 dysembryoplastic neuroepithelial ...
Duong Francois H T FH Department of Biomedicine; and 2 Division of Gastroenterology and Hepatology, University Hospital Basel; University of Basel, 4031 Basel, - - 2014
The molecular mechanisms that link IFN-λ3 genotypes to differential induction of interferon (IFN)-stimulated genes (ISGs) in the liver of patients with chronic hepatitis C (CHC) are not known. We measured the expression of IFN-λ and of the specific IFN-λ receptor chain (IFN-λR1) in 122 liver biopsies of patients with CHC ...
Jimbo Keisuke K Department of Pediatrics and Adolescent Medicine, Juntendo University Graduate School of Medicine, Tokyo, - - 2014
Although pediatric inflammatory bowel disease (IBD) is characterized by extensive intestinal involvement and rapid early progression, the precise etiology and the specific factors involved in disease aggravation have not been well established. To investigate the pathogenesis of pediatric IBD. The expression of inflammatory molecules in colon samples taken from active ...
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