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Gutowska-Owsiak D D MRC Human Immunology Unit, NIHR Biomedical Research Centre, University of Oxford, John Radcliffe Hospital, Weatherall Institute of Molecular Medicine, Oxford, OX3 9DS, - - 2014
Histamine is an abundant mediator accumulating in the skin of atopic patients where it is thought to be immune cell-derived. While keratinocytes express histidine decarboxylase (HDC), levels of the enzyme in normal or diseased epidermis and factors that influence its expression in human keratinocytes are not known. To assess levels ...
Wada Hiroshi H Department of Surgery, Graduate School of Medicine, Osaka University, Osaka, - - 2014
Hypoxia regulates the expression of genes that promote tumor growth, angiogenesis and invasion. We previously studied hypoxic tumor cells in vitro and from hepatic metastases of colorectal cancer and determined several potential prognostic factors for hepatocellular carcinoma (HCC). In this study, we evaluated the prognostic impact of the expression of ephrin-A1 ...
Gu Hongmei H Center for Immunobiology and Pulmonary Division, Department of Medicine, Department of Pathology, Department of Surgery, and Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA; andCenter for Immunobiology and Pulmonary Division, Department of Medicine, Department of Pathology, Department of Surgery, and Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA; - - 2014
The epithelial complement inhibitory proteins (CIPs) cluster of differentiation 46 and 55 (CD46 and CD55) regulate circulating immune complex-mediated complement activation in idiopathic pulmonary fibrosis (IPF). Our previous studies demonstrated that IL-17A mediates epithelial injury via transforming growth factor β1 (TGF-β1) and down-regulates CIPs. In the current study, we examined ...
Park Jung-Sub JS Department of Pharmacology,Department of Otolaryngology,Neuroscience Graduate Program, Department of Biological Sciences,Chronic Inflammatory Disease Research Center, - - 2014
Noise-induced hearing loss is one of the most common types of sensorineural hearing loss. In this study, we examined the expression and localization of leukotriene receptors and their respective changes in the cochlea after hazardous noise exposure. We found that the expression of cysteinyl leukotriene type 1 receptor (CysLTR1) was ...
Tang Chun-Yan - - 2014
Abstract Background: Aberrant expression of SRY-box containing gene 17 (SOX17) has been observed in several solid tumors. However, little is known about SOX17 expression in acute myeloid leukemia (AML). The purpose of this study was to investigate the alteration of SOX17 expression and to explore its clinical significance in AML. ...
Matsushima Asako A *Critical Care and Trauma Center, Osaka General Medical Center, Osaka; †Department of Traumatology and Acute Critical Medicine, Osaka University Graduate School of Medicine, Osaka; and ‡Hoshigaoka Koseinenkin Hospital, Osaka, - - 2014
Aquaporins (AQPs) are water channels of cell membranes. All living cells experience osmotic pressure changes in their environment, but the mechanism by which water influx occurs was not known until the discovery of AQPs. AQP9, which is expressed on human polymorphonuclear leukocytes (PMNLs), is reported to relate to morphologic changes ...
Cui Hong-Kai HK Department of Interventional Radiology, The First Affiliated Hospital of Xinxiang Medical University, Weihui, Henan 453100, P.R. - - 2014
Subarachnoid hemorrhage (SAH), one of the serious types of stroke incurred by bleeding into the space surrounding the brain, occurs when brains are deprived of oxygen by various factors, particularly an interruption to the blood supply or a ruptured aneurysm. Cerebral vasospasm (CVS) is one of the most common complications ...
Zhu Wang-Yu WY Department of Cardio-Thoracic Surgery, Zhoushan Hospital , Zhoushan, Zhejiang , China - - 2014
Aberrant expression of various microRNAs (miRNA) has shown diagnostic and prognostic significance in non-small cell lung cancer (NSCLC). qRT-PCR analysis confirmed altered expression of miR-125a-5p, let-7e, miR-30a, miR-30e and miR-30e-3p in 70 paired tissue and serum samples from NSCLC patients. The reduced expression of miR-125a-5p, let-7e and miR-30e was strongly ...
Berschneider Barbara B Comprehensive Pneumology Center, Ludwig Maximilians University, University Hospital Grosshadern, and Helmholtz Zentrum München, Munich, Germany, Member of the German Center for Lung - - 2014
Idiopathic pulmonary fibrosis (IPF) is the most common and fatal form of idiopathic interstitial pneumonia. MicroRNAs (miRNAs), short, single-stranded RNAs that regulate protein expression in a post-transcriptional manner, have recently been demonstrated to contribute to IPF pathogenesis. We have previously identified WNT1-inducible signaling pathway protein 1 (WISP1) as a highly ...
Grgic Ivica I 1] Renal Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA [2] Department of Internal Medicine and Nephrology, Philipps-University, Marburg, - - 2014
Identifying new biomarkers and therapeutic targets for podocytopathies such as focal segmental glomerulosclerosis (FSGS) requires a detailed analysis of transcriptional changes in podocytes over the course of disease. Here we used translating ribosome affinity purification (TRAP) to isolate and profile podocyte-specific mRNA in two different models of FSGS. We expressed ...
Inui Shigeki S Department of Regenerative Dermatology, Osaka University Graduate School of Medicine, Suita, - - 2014
Proteoglycans have been suggested to play pivotal roles in hair biology. Decorin is a prototypical member of the small leucine-rich proteoglycan family, which is involved in numerous biological processes. However, the role of decorin in the hair cycle has not been elucidated. Moreover, the effects of decorin on the activities ...
Ji Ling - - 2014
Decreased Core I beta3-Gal-T-specific molecular chaperone (Cosmc) expression induced IgA1 aberrant glycosylation is the main characteristic of IgA nephropathy (IgAN).This study tried to elucidate the effect of Astragalus membranaceus on Cosmc expression and IgA O-glycosylation of peripheral B lymphocytes in IgAN patients. Peripheral B lymphocytes of 21 IgAN patients and ...
Li Bing B The State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, - - 2014
Behçet's disease (BD) is an autoimmune disease of unknown etiology. Interleukin-28A (IL-28A) promotes immune responses and may participate in the pathogenesis of autoimmune diseases. To examine the role of IL-28A in the pathogenesis of BD, we measured the expression of IFN-γ and IL-17 by IL-28A-stimulated peripheral blood mononuclear cells (PBMCs) ...
Ruiz Ibán Miguel Ángel MA Unidad de Hombro y Codo, Servicio de Traumatología y Cirugía Ortopédica, Hospital Universitario Ramón y Cajal, Madrid, Spain. Electronic address: - - 2014
To define the variations in the expression of 5 growth factor genes in meniscal tissue after a lesion is created in the avascular zone of the medial meniscus of the rabbit. A longitudinal lesion was created in the avascular zone of the anterior horn of the medial meniscus in 42 ...
Mulay Kaustubh K National Reporting Centre for Ophthalmic Pathology, Centre for Sight, Hyderabad, India; Ocular Pathology Service, L.V.Prasad Eye Institute, Hyderabad, - - 2014
The study aimed at evaluating the expression of androgen receptor (AR) and nuclear survivin (NS) in periocular sebaceous gland carcinoma (SGC) and to determine whether this expression is associated with histopathological features, markers of apoptosis and proliferation and with clinical outcomes. This was a retrospective, comparative case series which included ...
Allon Irit I Department of Oral Pathology and Oral Medicine, The Maurice and Gabriela Goldschleger School of Dental Medicine, Tel Aviv University, Tel Aviv, - - 2014
To investigate the expression of anti- and proapoptosis markers, metallothionein (MT), and caspase-2, in the epithelial and inflammatory cells of oral lichen planus (OLP) patients, and to investigate the association with clinical parameters. Included were biopsies of 70 OLP patients. The clinical data were collected from patients' charts. The expression ...
Bakri M M MM Department of Oral Biology and Biomedical Sciences, Faculty of Dentistry, University of Malaya, Kuala Lumpur, - - 2014
The aim of this study was to investigate the relationship between expression of Candida albicans alcohol dehydrogenases (ADH) genes in archival formalin-fixed paraffin-embedded (FFPE) samples from biopsies of leukoplakia. Archival FFPE samples were obtained from four sample groups: normal oral mucosa, non-dysplastic leukoplakia, chronic hyperplastic candidosis (CHC), and non-CHC dysplastic ...
Yang Xiaoqing X Department of Pathology, Shandong University Medical School, Jinan, Shandong, P.R. - - 2014
Cholangiocarcinoma (CCA) is a highly lethal malignancy of the biliary tract with very few treatment options. Epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor (HER2) have been considered as potential therapeutic targets in CCA. In the present study, we attempted to clarify the clinicopathological significance of all ...
Sherrill J D JD Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, - - 2014
Eosinophilic esophagitis (EoE) is an allergic inflammatory disorder of the esophagus that is compounded by genetic predisposition and hypersensitivity to environmental antigens. Using high-density oligonucleotide expression chips, a disease-specific esophageal transcript signature was identified and was shown to be largely reversible with therapy. In an effort to expand the molecular ...
Yoo Tae-Hyun TH Department of Medicine, Division of Nephrology and Hypertension, Peggy and Harold Katz Family Drug Discovery Center and Department of Internal Medicine, Division of Nephrology, Yonsei University College of Medicine, Seoul, - - 2014
Diabetic kidney disease (DKD) is the most common cause of ESRD in the United States. Podocyte injury is an important feature of DKD that is likely to be caused by circulating factors other than glucose. Soluble urokinase plasminogen activator receptor (suPAR) is a circulating factor found to be elevated in ...
Kim Y-J YJ Department of Anatomy and Neurobiology, College of Medicine, Hallym University, Chunchon 200-702, South Korea; Institute of Epilepsy Research, College of Medicine, Hallym University, Chunchon 200-702, South - - 2014
In the present study, we addressed the question of whether the up-regulation of laminin expression represents the astroglio-vascular responses to status epilepticus (SE) in an effort to better understand the role of vasogenic edema in epileptogenic insult. In the hippocampus, vasogenic edema was observed in the hippocampus 12 h after ...
Su C-Y CY Genomics Research Center, Academia Sinica, Taipei, - - 2014
Methylthioadenosine phosphorylase (MTAP), a ubiquitously expressed protein, plays important roles in purine biosynthesis. Locating near to each other on chromosome 9p21-22, codeletion of the MTAP and p16(Ink4A) genes have been reported in non-small cell lung cancer (NSCLC). The aim of this study is to determine the respective prognostic value of ...
Agrawal Shipra S Center for Clinical and Translational Research, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio, - - 2014
Albuminuria is both a hallmark and a risk factor for progressive glomerular disease, and results in increased exposure of podocytes to serum albumin with its associated factors. Here in vivo and in vitro models of serum albumin-overload were used to test the hypothesis that albumin-induced proteinuria and podocyte injury directly ...
Lai Chun-Fu CF National Taiwan University Hospital and College of - - 2014
Emerging data have suggested that acute kidney injury (AKI) is often incompletely repaired and can lead to chronic kidney disease (CKD), which is characterized by tubulointerstitial inflammation and fibrosis. However, the underlying mechanisms linking AKI to CKD remain obscure. This study aimed to investigate the role of Cysteine-rich protein 61 ...
Suga Hiraku H Department of Dermatology, University of - - 2014
Purpose: Atopic dermatitis (AD) is characterized by decreased expression of filaggrin and loricrin. AD patients often suffer from skin infections, which are also frequently seen in patients with cutaneous T-cell lymphoma (CTCL). In this study, we aimed to investigate the skin barrier in CTCL. Experimental Design: We assessed skin moisture ...
Misra Maneesh Kumar MK Department of Medical genetics, Sanjay Gandhi Post-graduate Institute of Medical Sciences, Raebareli Road, Lucknow-226014 (UP), India; Department of Anatomy, Institute of Medical Sciences, Banaras Hindu University, Varanasi-221005 (UP), - - 2014
Human leukocyte antigen (HLA)-G is a non-classical major-histocompatibility complex class-I molecule associated with immunosuppressive function. We have evaluated the impact of HLA-G allele associated with untranslated-region (UTR)-haplotype in end stage renal disease (ESRD) and acute allograft rejection (AR) cases. The mRNA levels of different HLA-G isoforms were evaluated in ESRD ...
Sharawat Surender Kumar SK Department of Medical Oncology, Dr. B.R.A. Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi, - - 2014
Acute myeloid leukemia is characterized by accumulation of immature cells because of imbalance between proliferation and apoptosis. In AML, simultaneous expression of proliferative (FLT-3, c-KIT) and antiapoptotic genes (BCL-2), are unknown. We prospectively assessed proliferative and antiapoptotic gene transcripts using Taqman probe chemistry in 48 adult AML patients. A stepwise Cox ...
Breccia Massimo M Department of Cellular Biotechnologies and Hematology, Sapienza University, Via Benevento 6, 00161, Rome, Italy, - - 2014
Potential clinical significance of CD34 expression in acute promyelocitic leukemia (APL) has not been deeply investigated. We hereby analyzed the clinico-biological features and treatment outcome of APL patients in relation to CD34 expression, even when expressed in a small subpopulation: 114 APL patients homogeneously treated with the AIDA schedule were ...
Hen-Avivi Shelly S Department of Plant Sciences, Weizmann Institute of Science, Rehovot 76100, - - 2014
The hydrophobic cuticular membrane of land plants performs a number of important roles during fruit development, including protection from a range of abiotic and biotic stresses. The components of the fleshy fruit cuticle are synthesized and secreted from the epidermal cells. While the biosynthetic and transport pathways of the cuticle ...
Schelbergen R F RF Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands. Electronic address: - - 2014
Synovitis is evident in a substantial subpopulation of patients with osteoarthritis (OA) and is associated with development of pathophysiology. Recently we have shown that adipose-derived stem cells (ASC) inhibit joint destruction in collagenase-induced experimental OA (CIOA). In the current study we explored the role of synovitis and alarmins S100A8/A9 in ...
Guo Zhen Z Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, No. 305 East Zhongshan Road, Nanjing, PR - - 2014
MicroRNAs (miRNAs) play an important role in inflammation. Several studies have reported the unique miRNAs profiles in colonic mucosa and peripheral blood of patients with active Crohn's disease (CD). But there is limited data about the miRNA profiles of terminal ileum, the most commonly involved location, especially the non-inflamed mucosa. ...
Xie Hong H Department of Urology, Shanghai Jiaotong University Affiliated Shanghai Sixth Hospital, Shanghai, 200233, People's Republic of China, - - 2014
Urethral fibrosis is an important pathological feature of urethral stricture. TGF-β1 and CXC chemokine receptor 3 (CXCR3) signaling have been reported as the critical pathways involved in the pathology of fibrosis. Here, we collected the urine samples from the patients with recurring urethral stricture, recurring stricture treated by cystostomy, and ...
Blum Roy R Laura and Isaac Perlmutter Cancer Center, Department of Pathology, New York University School of Medicine, 522 1st Avenue, New York, NY 10016, - - 2014
The early 1980s revelation of cis-acting genomic elements, known as transcriptional enhancers, is still regarded as one of the fundamental discoveries in the genomic field. However, only with the emergence of genome-wide techniques has the genuine biological scope of enhancers begun to be fully uncovered. Massive scientific efforts of multiple ...
Sheng Shu-Jing SJ Guangzhou Quality R&D Center of Traditional Chinese Medicine, Guangdong Key Laboratory of Plant Resources, School of Life Sciences, Sun Yat-Sen University, Guangzhou, Guangdong 510275, P.R. - - 2014
Acute lung injury (ALI) is characterized by pulmonary edema, in which the epithelial sodium channel (ENaC) has a critical role in the clearance of edema fluid from the alveolar space. Lipopolysaccharide (LPS), frequently employed to induce ALI in experimental animal models, has been reported to regulate ENaC expression and alveolar ...
Tawdy Mohamed H MH Department of Neurology, Cairo University, El Manial Street, 11354 Cairo, - - 2014
One of the presumed pathological mechanisms of multiple sclerosis (MS) is the failure of apoptosis of autoreactive T lymphocytes. This study aimed to determine the relationship of the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) mRNA gene expression ratio and serum TRAIL levels with MS and brain atrophy. This study was ...
Lan Xiqian X Feinstein Institute for Medical Research, Hofstra North Shore LIJ Medical - - 2014
Development of higher rates of non-diabetic glomerulosclerosis (GS) in African Americans has been attributed to two coding sequence variants (G1 and G2) in the APOL1 gene. To date, the cellular function and the role of APOL1variants (Vs) in GS are still unknown. In this study, we examined the effects of ...
Screen Mark M Folkhälsan Institute of Genetics and Department of Medical Genetics, Haartman Institute, University of Helsinki, Helsinki, - - 2014
Myotonic dystrophy type 2 (DM2) is a multisystemic disorder caused by a (CCTG)n repeat expansion in intron 1 of CNBP. Transcription of the mutant noncoding repeats causes a toxic RNA gain of function that involves the accumulation of the repeats in ribonuclear foci. This leads to sequestration of splicing factors ...
Wang Qiang Q Department of Orthopedics, Jinling Hospital, Southern Medical University, Nanjing, 210002, - - 2014
The objective of this study was to investigate the expression of adiponectin receptors (AdipoR1, R2, and T-cadherin) in both normal subjects and patients with knee osteoarthritis (OA). We used immunofluorescence to assess expression of adiponectin receptors in the chondrocytes of normal subjects (n = 3) and OA patients (n = 3). We also studied ...
Koon Hon Wai HW Center for Inflammatory Bowel Diseases, Division of Digestive Diseases, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA 90095, - - 2014
Clostridium difficile infection (CDI) is a common, debilitating infection with high morbidity and mortality. C. difficile causes diarrhea and intestinal inflammation by releasing two toxins, toxin A and toxin B. The macrolide antibiotic fidaxomicin was recently shown to be effective in treating CDI and its beneficial effect was associated with ...
Pan Yanfang Y Department of Non-Communicable Diseases Control and Prevention, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou City, Zhejiang, P.R. China. Electronic address: - - 2014
Transcription factor prospero homeobox 1 (Prox-1) and podoplanin (PDPN), mucin-type transmembane protein, are both constantly expressed in lymphatic endothelial cells (LECs) and appear to function in an LEC-autonomous manner. Mice globally lacking PDPN (Pdpn(-/-)) develop abnormal and blood-filled lymphatic vessels that highly resemble those in inducible mice lacking Prox-1 (Prox1(-/-)). ...
Garbett Krassimira A KA Department of Psychiatry, Vanderbilt University, Nashville, - - 2014
Peripheral biomarkers for major psychiatric disorders have been an elusive target for the last half a century. Dermal fibroblasts are a simple, relevant, and much underutilized model for studying molecular processes of patients with affective disorders, as they share considerable similarity of signal transduction with neuronal tissue. Cultured dermal fibroblast ...
Bao Zhiyao Z Department of Respiratory Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; Department of Respiratory Medicine, Shanghai First People's Hospital, Shanghai Jiao Tong University, Shanghai 200080, - - 2014
Idiopathic pulmonary fibrosis (IPF) is a progressive diffuse parenchymal disease with a poor prognosis. A variety of cytokines and chemokines are involved in its pathophysiology. The aim of this study was to evaluate the clinical features in IPF patients with the expression of suppressor of cytokine signaling 1 (SOCS-1), which ...
Fujisawa Tomomi T Department of Dermatology, Gifu University Graduate School of Medicine, Gifu, - - 2014
Tricho-rhino-phalangeal syndrome (TRPS) is an autosomal-dominant disease characterized by sparse and slow-growing scalp hair and craniofacial and skeletal abnormalities. We report here the case of two girls and their father who had TRPS type 1 and received a diagnosis of a new mutation of TRPS1 based on their clinical symptoms. ...
Kim Jung-Eun JE Department of Dermatology, School of Medicine, The Catholic University of Korea, Seoul, - - 2014
The effects of the Notch signaling pathway in fibroproliferative skin diseases have not been fully elucidated. The aim of this study was to investigate the expression of activated Notch signaling molecules in various skin fibroproliferative diseases. Immunohistochemical analysis of Notch intracellular domain (NICD) expression in keloid, hypertrophic scar, morphea, dermatofibroma, ...
Wang Jin-Yang JY Metabolic Disease Center, School of Traditional Chinese Medicine, Capital Medical University, Beijing, China; Department of Endocrinology, Beijing Tongren hospital, Capital Medical University, Beijing, China; Department of Endocrine and metabolism, Capital Medical University, Beijing, China; Beijing Key Laboratory of Diabetes Research and Care, Beijing 100730, - - 2014
Epithelial-to-mesenchymal transition (EMT) plays an important role in renal interstitial fibrosis (RIF) with diabetic nephropathy (DN). Smad7(a inhibitory smad), a downstream signaling molecules of TGF-β1, represses the EMT. The physiological function of miR-21 is closely linked to EMT and RIF. However, it remained unclear whether miR-21 over-expression affected TGF-β1-induced EMT ...
Matsumoto Noriko N Department of Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, - - 2014
CD151 is a member of the tetraspanin family, which interacts with laminin-binding integrins and other tetraspanins. CD151 is involved in several pathologic activities associated with tumor progression, including metastasis and angiogenesis. The aim of this study was to clarify the clinical use of CD151 expression in gallbladder cancer (GBC). Forty-five ...
Zhu Xiao-Juan XJ Department of Haematology, Provincial Hospital affiliated to Shandong University, Jinan, - - 2014
To investigate the expression of Tumour Necrosis Factor Superfamily 13B (TNFSF13B) receptors in immune thrombocytopenia (ITP) and their correlation with disease activity, we investigated the protein and mRNA levels of TNFSF13B, Tumour Necrosis Factor Receptor Superfamily 13C (TNFRSF13C), TNFRSF13B and TNFRSF17 by flow cytometry, enzyme-linked immunosorbent assay and real time ...
Huang Yanhong - - 2014
The incidence of papillary thyroid cancer (PTC) is markedly higher in women than men during the reproductive years. In vitro studies have suggested that estrogen may play an important role in the development and progression of PTC through estrogen receptors (ERs). This study aimed to investigate the expression patterns of ...
Hountis Panagiotis P Department of Thoracic Surgery, Athens Naval Hospital, Deinokratous 70, 11521, Athens, Greece, - - 2014
S100A2 is a member of the EF-hand motif family S100. Its role has been recently implicated in carcinogenesis and metastasis. Although its precise role in NSCLC patients is debated and conflicting results have been published, it has been associated with patient survival. S100A2 expression was downregulated in some studies while ...
Fittipaldi Silvia S Unit of Vascular Surgery, Department of Specialty, Diagnostic and Experimental Medicine (DIMES), S.Orsola-Malpighi Hospital, Bologna University, Bologna, - - 2014
Introduction. Neoangiogenesis is crucial for the progression and vulnerability of atheromasic lesions. Since adult vasa vasorum, which represent the neoangiogenetic burden of healthy arteries, constitutively express Nestin and Wilms Tumor (WT1), the aims of the present study are: i) to describe and quantify Nestin and WT1 in plaque neovessels; ii) ...
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