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Zhang Jing J 1] Pediatric Cardiovascular Center, Children's Hospital of Fudan University, Shanghai, China [2] Shanghai Key Laboratory of Prevention and Intervention of Birth - - 2014
Background:As an important component of retinoid acid (RA) signaling pathway, the retinoid x receptor alpha (RXRA) is considered to play important role in the pathogenesis of tetralogy of Fallot (TOF).Methods:The expression level of RXRA mRNA and methylation status of the RXRA promoter region in 26 TOF patients and 6 controls ...
Mezentsev Alexandre A 119991, Moscow, Russia, Gubkina str., bld.3, of.302, Vavilov Institute of General Genetics RAS. Electronic address: - - 2014
This review summarizes the contribution of matrix metalloproteinases to the pathogenesis of psoriasis. In psoriasis, matrix metalloproteinases are involved in the structural changes of the epidermis via the modification of intracellular contacts and the composition of the extracellular matrix, promoting angiogenesis in the dermal blood vessels and the infiltration of ...
Dziunycz Piotr J PJ Department of Dermatology, University Hospital Zurich, Zurich, - - 2014
Cutaneous squamous cell carcinoma (SCC) represents the most important cutaneous complication following organ transplantation. It develops mostly on sun-exposed areas. A recent study showed the role of ATF3 in SCC development following treatment with calcineurin inhibitors. It has been reported that ATF3 which may act as an oncogene, is under ...
Suojalehto Hille H Control of Hypersensitivity Diseases Team, Finnish Institute of Occupational Health, Helsinki, - - 2014
Background: Asthma and allergic rhinitis (AR) commonly coexist and can be taken as manifestations of one syndrome. Evidence exists that microRNAs (miRNAs) are important in controlling inflammatory processes and they are considered promising biomarkers. However, little is known about the differences in miRNA expression in patients with chronic allergic airway ...
Chen Daishi D Department of Otolaryngology-Head and Neck Surgery, Chinese PLA General Hospital, Beijing, - - 2014
Chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by eosinophil-dominant infiltration in Europe and the United States. However, CRSwNP in Asia has shown different immunopathologic features. High-mobility group protein box 1 (HMGB1) is a DNA-binding protein that has been suggested to be involved in various chronic inflammatory diseases. The objective ...
Fraga-Silva R A - - 2014
Angiotensin (Ang)-(1-7), acting through the receptor Mas, has atheroprotective effects; however, its role on plaque vulnerability has been poorly studied. Here, we investigated the expression of the renin-angiotensin system (RAS) components in stable and unstable human carotid plaques. In addition, we evaluated the effects of the chronic treatment with an ...
Panchaprateep R R Division of Dermatology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, - - 2014
Of all the cytokines or growth factors which have been postulated to play a role in hair follicle, insulin-like growth factor-1 (IGF-1) is known to be regulated by androgens. However, how IGF-1 is altered in the balding scalp has not yet been investigated. In this study, expressions of IGF-1 and ...
Taurines Regina R Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University of Wuerzburg, Fuechsleinstraße 15, 97080, Wuerzburg, Germany, - - 2014
Findings from molecular genetic studies and analyses of postmortem and peripheral tissue led to the hypothesis that neurotrophins-as crucial moderators of neuroplasticity-impact on the pathophysiology of autism spectrum disorder (ASD). The study projects aimed to complement former results on the role of brain-derived neurotrophic factor (BDNF), a member of the ...
Yoon Sun-Young SY Department of Dermatology, Seoul National University College of Medicine, Seoul, Republic of Korea; Institute of Human-Environment Interface Biology, Seoul National University Medical Research Center, Seoul, Republic of Korea; Laboratory of Cutaneous Aging and Hair Research, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of - - 2014
The dermal papilla (DP) comprises specialized mesenchymal cells at the bottom of the hair follicle and plays a pivotal role in hair formation, anagen induction and the hair cycle. In this study, DPs were isolated from human hair follicles and serially subcultured. From each subculture at passages 1, 3, and ...
Chu Jessica Y S JY 1School of biological sciences, The University of Hong Kong, Pokfulam, Hong Kong SAR, - - 2014
MicroRNAs (miRNAs) are small, non-coding regulatory RNAs that act as posttranscriptional repressors by binding to the 3' untranslated region (3'UTR) of target genes. They require processing by Dicer, an RNase III enzyme, to become mature regulatory RNAs. Previous work from our laboratory revealed critical roles for miRNAs in nephron progenitors ...
Sakamoto Luis Henrique Toshihiro LH Laboratory of Molecular Pathology of Cancer, Faculty of Health Sciences, University of Brasilia, Brasilia, DF, Brazil; Cell Biology Department, University of Brasilia, Brasilia, DF, Brazil; Jose Alencar Children's Hospital of Brasilia, Brasilia, DF, - - 2014
Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy. Although several clinical characteristics can be associated with worse prognosis, more robust biological markers still remains uncovered. SMYD2, a member of SMYD protein family, regulates the activity of several proteins through methylation. In this study, we performed quantitative real time ...
Dorn Christoph C Department of Internal Medicine I, University Hospital Regensburg, Regensburg, - - 2014
Overnutrition is the major cause of nonalcoholic fatty liver disease (NAFLD) and its advanced form nonalcoholic steatohepatitis (NASH). We aimed to develop and characterize a murine model, which resembles both the pathology and nutritional situation, of NASH patients in Western societies. Mice were fed with a NASH-inducing diet (ND) containing ...
Luchetti Sabina S From the Departments of Neuroimmunology (SL, CGvE, KS, IH), Astrocyte Biology and Neurodegeneration (MEvS), and Neuropsychiatric Disorders (DFS), Netherlands Institute for Neuroscience, an Institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, The - - 2014
The basis of gender differences in the prevalence and clinical progression of multiple sclerosis (MS) is not understood. Here, we identify gender-specific responses in steroid synthesis and signaling in the brains of MS patients as possible contributors to these differences. We investigated gene expression changes in these pathways and of ...
Faloppa Carlos Chaves CC Departamento de Ginecologia Oncologica, Hospital AC Camargo, Rua Antonio Prudente, 211, 01509-010, Sao Paulo, Brazil; - - 2014
Objectives: To examine the immunohistochemical expression of cyclooxygenase-2 (COX-2) and nuclear factor-κB (NF-κB) in benign endometrial polyps (EPs), endometrial hyperplasia (EH), endometrial intraepithelial neoplasia (EIN), and endometrioid endometrial cancer (EC). Methods: The immunohistochemical expression of COX-2 and NF-κB was performed using an Aperio Scanscope XT automated system in 218 patients ...
Bao Shan S Department of Endocrinology, The First Affiliated Hospital, University of South China, Hengyang 421001, China; Department of Gynecology and Obstetrics, Hainan Provincial People's Hospital, Haikou 570311, - - 2014
To screen, identify, and compare the serum biomarkers between anovulatory dysfunctional uterine bleeding (ADUB) and ovulatory dysfunctional uterine bleeding (ODUB) in Lizu females. The subjects included 128 ADUB patients, 63 ODUB patients, and 93 controls. The serum and supernate of the subjects' mense were collected and stored at -80 °C ...
Ikumoto Taro T Department of Surgical and Molecular Pathology, Dokkyo University School of Medicine, Mibu, - - 2014
The aim of this study was to investigate the expression pattern of manganese superoxide dismutase (MnSOD) in relation to inflammatory factors in ulcerative colitis (UC) and characterize this enzyme as a newly identified biomarker potentially linked to disease pathogenesis of UC. MnSOD expression was analyzed immunohistochemically in 48 formalin-fixed and ...
Akhavan-Sigari Reza R University Medical Center Göttingen, Georg-August-University Göttingen, Germany. Robert-Koch-Strasse 40, 37075 Göttingen, Germany. - - 2014
Aim: To investigate the expression of platelet-derived growth factor (PDGF) receptor-A (PDGFRα), epidermal growth factor receptor (EGFR) and c-Met in spinal chordoma. To the authors' knowledge, little is known regarding the prognostic significance of receptor tyrosine kinase in spinal chordoma. Using immunohistochemical techniques, the authors investigated PDGFR-α, EGFR and c-MET ...
Wang Wei-Jun WJ Department of Spine Surgery, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, - - 2014
The molecular mechanism of low bone mass in girls with adolescent idiopathic scoliosis (AIS) has not been ascertained. Runx2 is a critical transcription factor regulating osteoblast differentiation and maturation. The present study aimed to explore the possible relationship between Runx2 expression in osteoblasts and bone mineral density (BMD) in subjects ...
Kwon Ji Hyun JH Department of Pathology, Kangdong Sacred Heart Hospital, Hallym University College of Medicine, Seoul, - - 2014
This study was aimed at investigating the relation of P2X7 receptor (P2X7R) expression with the clinicopathological features of papillary thyroid carcinoma (PTC) coexisting with Hashimoto's thyroiditis (HT). We examined 170 patients (84, PTC with HT; 86, PTC without HT). P2X7R expression was examined by immunohistochemical methods. The staining intensity and ...
Futamura Naohisa N Department of Orthopaedic Surgery, Nagoya University Graduate School and School of Medicine, 65-Tsurumai, Showa, Nagoya, Aichi, 466-8550, - - 2014
Several studies have focused on the relationships between the expression of extracellular matrix metalloproteinase inducer (EMMPRIN) and the prognosis of patients with malignant tumors. However, few of these have investigated the expression of EMMPRIN in osteosarcoma. We examined expression levels of EMMPRIN immunohistochemically in 53 cases of high-grade osteosarcoma of ...
Mouriaux Frederic F ophthalmology, CHU, av Cote de Nacre, Caen, 14033, - - 2014
Purpose. Overexpression of hypoxia inducible factor-1 alpha (HIF-1α) has been found in several cancers and is thought to correlate with aggressive disease. The purpose of our study was to investigate the influence of HIF-1α on clinical outcome in uveal melanoma (UM) along with proliferative (MIB-1) and vascular (CD31, VEGF-A) markers. ...
Wen Ping P Center for Kidney Disease, 2nd Affiliated Hospital, Nanjing Medical University, 262 Zhongshan North Road, Nanjing, Jiangsu 210003, - - 2014
Vascular calcification is highly prevalent in patients with chronic kidney disease (CKD) and contributes to increased risk of cardiovascular disease and mortality. Accumulated evidences suggested that vascular smooth muscle cells (VSMCs) to osteoblast-like cells transdifferentiation (VOT) plays a crucial role in promoting vascular calcification. MicroRNAs (miRNAs) are a novel class ...
Guo Wei W From the Department of Neurosurgery, Xinqiao Hospital, Third Military Medical University, Chongqing (WG, D-HZ, F-JS, Z-LZ, S-YL, C-QZ, HY);Department of Mathematics, Sichuan University, Chengdu (J-YY); and Department of Rehabilitation and Physical Therapy, Xinqiao Hospital, Third Military Medical University, Chongqing (QY), - - 2014
Focal cortical dysplasia (FCD) is a well-known cause of medically intractable epilepsy. To understand the potential role of the inflammatory cytokine interleukin 2 (IL-2) in the pathogenesis of FCD, we investigated the expression patterns of IL-2 and its receptors (IL-2Rs) in FCD and control samples that included epileptic neocortex from ...
Liu Xuehui X State Key Laboratory of Cardiovascular Disease, Division of Population Genetics, Fuwai Hospital & National Center of Cardiovascular Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100037, China; National Human Genome Center at Beijing, Beijing 100176, China. Electronic address: - - 2014
Coactivator-associated arginine methyltransferase 1 (CARM1) is essential for the activation of a subset of NF-кB-dependent genes, which code the chemokines triggering plaque vulnerability. Unstable atherosclerotic plaques lead to the onset of acute coronary syndrome (ACS). Therefore, we aimed to investigate whether CARM1 is involved in the pathogenesis of ACS and ...
Sanchooli Javad J Department of Immunology, Zabol University of Medical Sciences, Zabol, - - 2014
Matrix metalloproteinases (MMPs) play a critical role in the blood-brain barrier permeability and in invasion of the leukocytes into the central nervous system during multiple sclerosis (MS). In this respect, in the present study, we have evaluated the possible role of MMP-9 and MMP-2 on the expression of soluble CD154 ...
Xiao Y Y Hysterosopic Center, Fuxing Hospital, Capital Medical University , Beijing , P. R. - - 2014
Objective: This prospective study was designed to determine whether the expression of cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF) in the endometrial tissue obtained from the peri-implantation period of women with endometrial polyp (EP) differs from that of control subjects without a polyp. Methods: Endometrial samples were collected from ...
Kim Ki Hyun KH Department of - - 2014
Abstract Conclusion: Gankyrin seems to be a better biomarker for cholesteatoma compared with Ki-67. Objective: Gankyrin is an oncoprotein, and occurs in cancers but not in benign diseases. The goal of this study was to compare expression of gankyrin, p53, and a proliferation marker (Ki-67) in cholesteatoma and retroauricular skin ...
Bernardi Rick E RE Institute of Psychopharmacology, Central Institute of Mental Health, Medical Faculty Mannheim /University of Heidelberg, Mannheim, - - 2014
L-type calcium channel (LTCC) activity in the brain is mediated by 2 subtypes, Cav1.2 and Cav1.3. The individual contributions of these LTCC subtypes to the long-term pharmacological and behavioral effects of nicotine are unknown. Using quantitative in situ hybridization, we examined expression levels of Cav1.2 and Cav1.3 in forebrain regions ...
Cathcart Mary Clare MC Department of Surgery, Institute of Molecular Medicine, Trinity Health Sciences Centre, St. James's Hospital, Dublin 8, Ireland. Electronic address: - - 2014
Thromboxane synthase (TXS) metabolizes prostaglandin H2 into thromboxanes, which are biologically active on cancer cells. TXS over-expression has been reported in a range of cancers, and associated with angiogenesis and poor outcome. TXS has been identified as a potential therapeutic target in NSCLC. This study examines a link between TXS ...
Sun Wei W Reproductive Medical Center, the Second Hospital affiliated to Shandong University of Traditional Chinese Medicine, Jingba Road, Jinan, 250001, People's Republic of - - 2014
The aim of this study was to determine whether altered expression and distribution of calcium- and integrin-binding protein-1 (CIB1) is involved in the pathogenesis of patients with oligoasthenozoospermia. Sperm samples were obtained from 25 infertile Chinese men who had failed to achieve conception after a period of 1-2 y and ...
Lien Wen-Hui WH 1] Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller UniversityNew York New York 10065 USA - - 2014
Hair follicle stem cells (HFSCs) regenerate hair in response to Wnt signalling. Here, we unfold genome-wide transcriptional and chromatin landscapes of β-catenin-TCF3/4-TLE circuitry, and genetically dissect their biological roles within the native HFSC niche. We show that during HFSC quiescence, TCF3, TCF4 and TLE (Groucho) bind coordinately and transcriptionally repress ...
Lutz Mirjam I MI Institute of Neurology, Medical University of Vienna, AKH 4 J, Währinger Gürtel 18-20, 1097, Vienna, - - 2014
Aging is one of the major risk factors for Alzheimer's disease (AD). Sirtuins are associated with prolonged life span. To examine whether the expression levels of sirtuins associate with the progression of AD or not, we performed a comparative immunoblotting and immunohistochemical study of SIRT1, 3, and 5 in the ...
Rocci Alberto A Myeloma Unit, Division of Haematology, University of Torino, Azienda Ospedaliera Città della Salute e della Scienza di Torino, Torino, - - 2014
Abnormal activation of MET/HGF (Hepatocyte Growth Factor) pathway has been described in several tumours and increased HGF plasmatic levels have been detected in patients with aggressive multiple myeloma (MM). MET and HGF mRNA expression was investigated in 105 samples of purified plasma cells derived from newly diagnosed MM patients treated ...
Cheong Kyung Ah KA Department of Dermatology, Dongguk University Seoul, Graduate School of Medicine, Gyeonggi-do, South - - 2014
Skin irritation is one of the most common adverse reactions in hydroquinone (HQ) and retinoic acid (RA). Although melanocytes have rarely been considered to be involved in skin irritation, RA and particularly HQ could induce melanocyte toxicity, resulting in depigmentation. We chose S100B as a candidate gene for melanocytotoxicity from ...
Lameira Aladim Gomes AG João de Barros Barreto University Hospital, Belém, - - 2014
The aim of this study was to identify the expression of MCM3, Ki-67 and p27 in normal mucosa, leucoplakia and oral squamous cell carcinoma (OSCC) and determine whether altered expression could serve as a prognostic marker of a malignant progression of dysplastic lesions. The samples were collected from 37 patients ...
Wei Ning N College of Animal Science and Technology, Northwest A&F University, Yangling, - - 2014
The transcription factor PU.1 plays a key role in the development of immune system. Recent evidence demonstrated bidirectional transcription and a sense/antisense transcriptional regulatory manner in PU.1 locus. However, the effect of PU.1 mRNA and its antisense long non-coding RNA (AS lncRNA) on adaptive immunity in vivo is still not ...
Lindner Christian C Department of Psychiatry, University of Münster, Münster, - - 2014
Among the functional neuroimaging studies on emotional face processing in schizophrenia, few have used paradigms with facial expressions of disgust. In this study, we investigated whether schizophrenia patients show less insula activation to macro-expressions (overt, clearly visible expressions) and micro-expressions (covert, very brief expressions) of disgust than healthy controls. Furthermore, ...
Wang Xiao-Dong XD Department of Rheumatology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University Shanghai Institute of Rheumatology, Shanghai, PR - - 2014
The canonical WNT pathway has been implicated as playing important roles in the pathogenesis of a variety of kidney diseases. Recently, WNT pathway activity was reported to be elevated in the renal tissue of a lupus mouse model. This study aimed to evaluate the potential role of the WNT pathway ...
Gola Hannah H Clinical and Biological Psychology, University of Ulm, Ulm, - - 2014
Posttraumatic stress disorder (PTSD) is a serious psychiatric condition that was found to be associated with altered functioning of the hypothalamic-pituitary-adrenal (HPA) axis and changes in glucocorticoid (GC) responsiveness. The physiological actions of GCs are primarily mediated through GC receptors (GR) of which isoforms with different biological activities exist. This ...
Halt Kimmo K The Centre of Excellence in Cell-Extracellular Matrix Research, Oulu, - - 2014
Several Wnt proteins are expressed in the embryonic kidney during various stages of development. Gene knockout models and ex vivo studies have provided strong evidence that Wnt-mediated signals are essential in renal ontogeny. Perhaps the most critical factors, Wnt9b and Wnt4, function during the early phase when the cap mesenchyme ...
Yao Yao Y Laboratory of Neurobiology and Genetics, The Rockefeller University, 1230 York Avenue, New York, New York 10065, - - 2014
Blood brain barrier (BBB) breakdown is not only a consequence of but also contributes to many neurological disorders, including stroke and Alzheimer's disease. How the basement membrane (BM) contributes to the normal functioning of the BBB remains elusive. Here we use conditional knockout mice and an acute adenovirus-mediated knockdown model ...
Zhang Wei W Neural Stem Cell Research Lab, Research Department, National Neuroscience Institute, Singapore 308433, - - 2014
Amyloid precursor protein (APP) is a transmembrane glycoprotein proteolytically processed to release amyloid beta, a pathological hallmark of Alzheimer's disease. APP is expressed throughout the developing and mature brain; however, the primary function of this protein is unknown. We previously demonstrated that APP deficiency enhances neurogenesis, but the mechanisms underlying ...
Bai Ying - - 2014
It is widely known that castration has a significant effect on the accumulation of adipose tissue. microRNAs (miRNAs) are known to be involved in fat deposition and to be regulated by the androgen-induced androgen receptor (AR). However, there is little understanding of the relationship between miRNAs and fat deposition after ...
Su Zhenhong Z Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Center for Human Genome Research, Cardio-X Institute, Huazhong University of Science and Technology, Wuhan, P. R. China; Key Laboratory of Kidney Disease Pathogenesis and Intervention of Hubei Province, Key Discipline of Pharmacy of Hubei Department of Education, Medical College, Hubei Polytechnic University, Huangshi, Hubei, P. R. - - 2014
Hematopoiesis is a dynamic process by which peripheral blood lineages are developed. It is a process tightly regulated by many intrinsic and extrinsic factors, including transcriptional factors and signaling molecules. However, the epigenetic regulation of hematopoiesis, for example, regulation via microRNAs (miRNAs), remains incompletely understood. Here we show that miR-144 ...
Zhu Yanan Y Endodontic Department, Institute and Hospital of Stomatology, Nanjing University Medical School, Nanjing, - - 2014
Regulatory T cells (Tregs) have emerged as important mediators in inflammatory and autoimmune diseases. We investigated the possible involvement of Tregs in oral lichen planus (OLP) and the influence of clinical therapy (hydroxychloroquine and prednisone) on the frequencies of Tregs in OLP patients. One hundred fifty patients diagnosed with OLP ...
Linnertz Colton C Division of Neurology at the Department of Medicine, Duke University Medical Center, Durham, NC, - - 2014
We investigated the genomic region spanning the Translocase of the Outer Mitochondrial Membrane 40-kD (TOMM40) and Apolipoprotein E (APOE) genes, that has been associated with the risk and age of onset of late-onset Alzheimer's disease (LOAD) to determine whether a highly polymorphic, intronic poly-T within this region (rs10524523; hereafter, 523) ...
Martin Rebecca M RM Gray Institute for Radiation Oncology and Biology, Department of Oncology, University of Oxford, Oxford, - - 2014
Predictive assays are needed to help optimise treatment in muscle-invasive bladder cancer, where patients can be treated by either cystectomy or radical radiotherapy. Our finding that low tumour MRE11 expression is predictive of poor response to radiotherapy but not cystectomy was recently independently validated. Here we investigated further the mechanism ...
Xie Qiang Q Department of - - 2014
Background: Enhancer of Zeste Homolog 2 (EZH2) is a polycomb group protein that has been shown to be involved in the progression of multiple human cancers including melanoma. The expression of EZH2 in normal skin and in pre-malignant and malignant cutaneous squamous cell carcinoma (SCC) has not been studied. Objectives: ...
Seleit Iman I Department of Dermatology, Andrology and STDs, Faculty of Medicine, Menoufiya University, Menoufiya, - - 2014
The etiopathogenetic mechanisms leading to pigment loss in vitiligo are not fully understood. Notch signaling is required for development and maintenance of melanocyte lineage and acts as a key component among keratinocyte-melanocyte interactions. The current study aimed to investigate the possible role of Notch signaling and its effect on the ...
Cardo Lucía F LF Genética Molecular-Laboratorio de Medicina, Hospital Universitario Central de Asturias, Oviedo, - - 2014
Mutations in the alpha-synuclein (SNCA) gene cause autosomal dominant Parkinsońs disease (PD). Common SNCA polymorphisms have been associated with the risk of developing PD. Abnormal expression and post-translational modification of SNCA has been found in PD-brains. In addition to a full length transcript (SNCA-140) there are three short isoforms (SNCA-98, ...
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