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Faloppa Carlos Chaves CC Departamento de Ginecologia Oncologica, Hospital AC Camargo, Rua Antonio Prudente, 211, 01509-010, Sao Paulo, Brazil; - - 2014
Objectives: To examine the immunohistochemical expression of cyclooxygenase-2 (COX-2) and nuclear factor-κB (NF-κB) in benign endometrial polyps (EPs), endometrial hyperplasia (EH), endometrial intraepithelial neoplasia (EIN), and endometrioid endometrial cancer (EC). Methods: The immunohistochemical expression of COX-2 and NF-κB was performed using an Aperio Scanscope XT automated system in 218 patients ...
Bao Shan S Department of Endocrinology, The First Affiliated Hospital, University of South China, Hengyang 421001, China; Department of Gynecology and Obstetrics, Hainan Provincial People's Hospital, Haikou 570311, - - 2014
To screen, identify, and compare the serum biomarkers between anovulatory dysfunctional uterine bleeding (ADUB) and ovulatory dysfunctional uterine bleeding (ODUB) in Lizu females. The subjects included 128 ADUB patients, 63 ODUB patients, and 93 controls. The serum and supernate of the subjects' mense were collected and stored at -80 °C ...
Ikumoto Taro T Department of Surgical and Molecular Pathology, Dokkyo University School of Medicine, Mibu, - - 2014
The aim of this study was to investigate the expression pattern of manganese superoxide dismutase (MnSOD) in relation to inflammatory factors in ulcerative colitis (UC) and characterize this enzyme as a newly identified biomarker potentially linked to disease pathogenesis of UC. MnSOD expression was analyzed immunohistochemically in 48 formalin-fixed and ...
Akhavan-Sigari Reza R University Medical Center Göttingen, Georg-August-University Göttingen, Germany. Robert-Koch-Strasse 40, 37075 Göttingen, Germany. - - 2014
Aim: To investigate the expression of platelet-derived growth factor (PDGF) receptor-A (PDGFRα), epidermal growth factor receptor (EGFR) and c-Met in spinal chordoma. To the authors' knowledge, little is known regarding the prognostic significance of receptor tyrosine kinase in spinal chordoma. Using immunohistochemical techniques, the authors investigated PDGFR-α, EGFR and c-MET ...
Wang Wei-Jun WJ Department of Spine Surgery, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, - - 2014
The molecular mechanism of low bone mass in girls with adolescent idiopathic scoliosis (AIS) has not been ascertained. Runx2 is a critical transcription factor regulating osteoblast differentiation and maturation. The present study aimed to explore the possible relationship between Runx2 expression in osteoblasts and bone mineral density (BMD) in subjects ...
Kwon Ji Hyun JH Department of Pathology, Kangdong Sacred Heart Hospital, Hallym University College of Medicine, Seoul, - - 2014
This study was aimed at investigating the relation of P2X7 receptor (P2X7R) expression with the clinicopathological features of papillary thyroid carcinoma (PTC) coexisting with Hashimoto's thyroiditis (HT). We examined 170 patients (84, PTC with HT; 86, PTC without HT). P2X7R expression was examined by immunohistochemical methods. The staining intensity and ...
Futamura Naohisa N Department of Orthopaedic Surgery, Nagoya University Graduate School and School of Medicine, 65-Tsurumai, Showa, Nagoya, Aichi, 466-8550, - - 2014
Several studies have focused on the relationships between the expression of extracellular matrix metalloproteinase inducer (EMMPRIN) and the prognosis of patients with malignant tumors. However, few of these have investigated the expression of EMMPRIN in osteosarcoma. We examined expression levels of EMMPRIN immunohistochemically in 53 cases of high-grade osteosarcoma of ...
Mouriaux Frederic F ophthalmology, CHU, av Cote de Nacre, Caen, 14033, - - 2014
Purpose. Overexpression of hypoxia inducible factor-1 alpha (HIF-1α) has been found in several cancers and is thought to correlate with aggressive disease. The purpose of our study was to investigate the influence of HIF-1α on clinical outcome in uveal melanoma (UM) along with proliferative (MIB-1) and vascular (CD31, VEGF-A) markers. ...
Wen Ping P Center for Kidney Disease, 2nd Affiliated Hospital, Nanjing Medical University, 262 Zhongshan North Road, Nanjing, Jiangsu 210003, - - 2014
Vascular calcification is highly prevalent in patients with chronic kidney disease (CKD) and contributes to increased risk of cardiovascular disease and mortality. Accumulated evidences suggested that vascular smooth muscle cells (VSMCs) to osteoblast-like cells transdifferentiation (VOT) plays a crucial role in promoting vascular calcification. MicroRNAs (miRNAs) are a novel class ...
Guo Wei W From the Department of Neurosurgery, Xinqiao Hospital, Third Military Medical University, Chongqing (WG, D-HZ, F-JS, Z-LZ, S-YL, C-QZ, HY);Department of Mathematics, Sichuan University, Chengdu (J-YY); and Department of Rehabilitation and Physical Therapy, Xinqiao Hospital, Third Military Medical University, Chongqing (QY), - - 2014
Focal cortical dysplasia (FCD) is a well-known cause of medically intractable epilepsy. To understand the potential role of the inflammatory cytokine interleukin 2 (IL-2) in the pathogenesis of FCD, we investigated the expression patterns of IL-2 and its receptors (IL-2Rs) in FCD and control samples that included epileptic neocortex from ...
Liu Xuehui X State Key Laboratory of Cardiovascular Disease, Division of Population Genetics, Fuwai Hospital & National Center of Cardiovascular Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100037, China; National Human Genome Center at Beijing, Beijing 100176, China. Electronic address: - - 2014
Coactivator-associated arginine methyltransferase 1 (CARM1) is essential for the activation of a subset of NF-кB-dependent genes, which code the chemokines triggering plaque vulnerability. Unstable atherosclerotic plaques lead to the onset of acute coronary syndrome (ACS). Therefore, we aimed to investigate whether CARM1 is involved in the pathogenesis of ACS and ...
Xiao Y Y Hysterosopic Center, Fuxing Hospital, Capital Medical University , Beijing , P. R. - - 2014
Objective: This prospective study was designed to determine whether the expression of cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF) in the endometrial tissue obtained from the peri-implantation period of women with endometrial polyp (EP) differs from that of control subjects without a polyp. Methods: Endometrial samples were collected from ...
Kim Ki Hyun KH Department of - - 2014
Abstract Conclusion: Gankyrin seems to be a better biomarker for cholesteatoma compared with Ki-67. Objective: Gankyrin is an oncoprotein, and occurs in cancers but not in benign diseases. The goal of this study was to compare expression of gankyrin, p53, and a proliferation marker (Ki-67) in cholesteatoma and retroauricular skin ...
Bernardi Rick E RE Institute of Psychopharmacology, Central Institute of Mental Health, Medical Faculty Mannheim /University of Heidelberg, Mannheim, - - 2014
L-type calcium channel (LTCC) activity in the brain is mediated by 2 subtypes, Cav1.2 and Cav1.3. The individual contributions of these LTCC subtypes to the long-term pharmacological and behavioral effects of nicotine are unknown. Using quantitative in situ hybridization, we examined expression levels of Cav1.2 and Cav1.3 in forebrain regions ...
Cathcart Mary Clare MC Department of Surgery, Institute of Molecular Medicine, Trinity Health Sciences Centre, St. James's Hospital, Dublin 8, Ireland. Electronic address: - - 2014
Thromboxane synthase (TXS) metabolizes prostaglandin H2 into thromboxanes, which are biologically active on cancer cells. TXS over-expression has been reported in a range of cancers, and associated with angiogenesis and poor outcome. TXS has been identified as a potential therapeutic target in NSCLC. This study examines a link between TXS ...
Sun Wei W Reproductive Medical Center, the Second Hospital affiliated to Shandong University of Traditional Chinese Medicine, Jingba Road, Jinan, 250001, People's Republic of - - 2014
The aim of this study was to determine whether altered expression and distribution of calcium- and integrin-binding protein-1 (CIB1) is involved in the pathogenesis of patients with oligoasthenozoospermia. Sperm samples were obtained from 25 infertile Chinese men who had failed to achieve conception after a period of 1-2 y and ...
Lien Wen-Hui WH 1] Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller UniversityNew York New York 10065 USA - - 2014
Hair follicle stem cells (HFSCs) regenerate hair in response to Wnt signalling. Here, we unfold genome-wide transcriptional and chromatin landscapes of β-catenin-TCF3/4-TLE circuitry, and genetically dissect their biological roles within the native HFSC niche. We show that during HFSC quiescence, TCF3, TCF4 and TLE (Groucho) bind coordinately and transcriptionally repress ...
Lutz Mirjam I MI Institute of Neurology, Medical University of Vienna, AKH 4 J, Währinger Gürtel 18-20, 1097, Vienna, - - 2014
Aging is one of the major risk factors for Alzheimer's disease (AD). Sirtuins are associated with prolonged life span. To examine whether the expression levels of sirtuins associate with the progression of AD or not, we performed a comparative immunoblotting and immunohistochemical study of SIRT1, 3, and 5 in the ...
Rocci Alberto A Myeloma Unit, Division of Haematology, University of Torino, Azienda Ospedaliera Città della Salute e della Scienza di Torino, Torino, - - 2014
Abnormal activation of MET/HGF (Hepatocyte Growth Factor) pathway has been described in several tumours and increased HGF plasmatic levels have been detected in patients with aggressive multiple myeloma (MM). MET and HGF mRNA expression was investigated in 105 samples of purified plasma cells derived from newly diagnosed MM patients treated ...
Cheong Kyung Ah KA Department of Dermatology, Dongguk University Seoul, Graduate School of Medicine, Gyeonggi-do, South - - 2014
Skin irritation is one of the most common adverse reactions in hydroquinone (HQ) and retinoic acid (RA). Although melanocytes have rarely been considered to be involved in skin irritation, RA and particularly HQ could induce melanocyte toxicity, resulting in depigmentation. We chose S100B as a candidate gene for melanocytotoxicity from ...
Lameira Aladim Gomes AG João de Barros Barreto University Hospital, Belém, - - 2014
The aim of this study was to identify the expression of MCM3, Ki-67 and p27 in normal mucosa, leucoplakia and oral squamous cell carcinoma (OSCC) and determine whether altered expression could serve as a prognostic marker of a malignant progression of dysplastic lesions. The samples were collected from 37 patients ...
Wei Ning N College of Animal Science and Technology, Northwest A&F University, Yangling, - - 2014
The transcription factor PU.1 plays a key role in the development of immune system. Recent evidence demonstrated bidirectional transcription and a sense/antisense transcriptional regulatory manner in PU.1 locus. However, the effect of PU.1 mRNA and its antisense long non-coding RNA (AS lncRNA) on adaptive immunity in vivo is still not ...
Lindner Christian C Department of Psychiatry, University of Münster, Münster, - - 2014
Among the functional neuroimaging studies on emotional face processing in schizophrenia, few have used paradigms with facial expressions of disgust. In this study, we investigated whether schizophrenia patients show less insula activation to macro-expressions (overt, clearly visible expressions) and micro-expressions (covert, very brief expressions) of disgust than healthy controls. Furthermore, ...
Wang Xiao-Dong XD Department of Rheumatology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University Shanghai Institute of Rheumatology, Shanghai, PR - - 2014
The canonical WNT pathway has been implicated as playing important roles in the pathogenesis of a variety of kidney diseases. Recently, WNT pathway activity was reported to be elevated in the renal tissue of a lupus mouse model. This study aimed to evaluate the potential role of the WNT pathway ...
Gola Hannah H Clinical and Biological Psychology, University of Ulm, Ulm, - - 2014
Posttraumatic stress disorder (PTSD) is a serious psychiatric condition that was found to be associated with altered functioning of the hypothalamic-pituitary-adrenal (HPA) axis and changes in glucocorticoid (GC) responsiveness. The physiological actions of GCs are primarily mediated through GC receptors (GR) of which isoforms with different biological activities exist. This ...
Halt Kimmo K The Centre of Excellence in Cell-Extracellular Matrix Research, Oulu, - - 2014
Several Wnt proteins are expressed in the embryonic kidney during various stages of development. Gene knockout models and ex vivo studies have provided strong evidence that Wnt-mediated signals are essential in renal ontogeny. Perhaps the most critical factors, Wnt9b and Wnt4, function during the early phase when the cap mesenchyme ...
Yao Yao Y Laboratory of Neurobiology and Genetics, The Rockefeller University, 1230 York Avenue, New York, New York 10065, - - 2014
Blood brain barrier (BBB) breakdown is not only a consequence of but also contributes to many neurological disorders, including stroke and Alzheimer's disease. How the basement membrane (BM) contributes to the normal functioning of the BBB remains elusive. Here we use conditional knockout mice and an acute adenovirus-mediated knockdown model ...
Zhang Wei W Neural Stem Cell Research Lab, Research Department, National Neuroscience Institute, Singapore 308433, - - 2014
Amyloid precursor protein (APP) is a transmembrane glycoprotein proteolytically processed to release amyloid beta, a pathological hallmark of Alzheimer's disease. APP is expressed throughout the developing and mature brain; however, the primary function of this protein is unknown. We previously demonstrated that APP deficiency enhances neurogenesis, but the mechanisms underlying ...
Bai Ying - - 2014
It is widely known that castration has a significant effect on the accumulation of adipose tissue. microRNAs (miRNAs) are known to be involved in fat deposition and to be regulated by the androgen-induced androgen receptor (AR). However, there is little understanding of the relationship between miRNAs and fat deposition after ...
Su Zhenhong Z Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Center for Human Genome Research, Cardio-X Institute, Huazhong University of Science and Technology, Wuhan, P. R. China; Key Laboratory of Kidney Disease Pathogenesis and Intervention of Hubei Province, Key Discipline of Pharmacy of Hubei Department of Education, Medical College, Hubei Polytechnic University, Huangshi, Hubei, P. R. - - 2014
Hematopoiesis is a dynamic process by which peripheral blood lineages are developed. It is a process tightly regulated by many intrinsic and extrinsic factors, including transcriptional factors and signaling molecules. However, the epigenetic regulation of hematopoiesis, for example, regulation via microRNAs (miRNAs), remains incompletely understood. Here we show that miR-144 ...
Zhu Yanan Y Endodontic Department, Institute and Hospital of Stomatology, Nanjing University Medical School, Nanjing, - - 2014
Regulatory T cells (Tregs) have emerged as important mediators in inflammatory and autoimmune diseases. We investigated the possible involvement of Tregs in oral lichen planus (OLP) and the influence of clinical therapy (hydroxychloroquine and prednisone) on the frequencies of Tregs in OLP patients. One hundred fifty patients diagnosed with OLP ...
Linnertz Colton C Division of Neurology at the Department of Medicine, Duke University Medical Center, Durham, NC, - - 2014
We investigated the genomic region spanning the Translocase of the Outer Mitochondrial Membrane 40-kD (TOMM40) and Apolipoprotein E (APOE) genes, that has been associated with the risk and age of onset of late-onset Alzheimer's disease (LOAD) to determine whether a highly polymorphic, intronic poly-T within this region (rs10524523; hereafter, 523) ...
Martin Rebecca M RM Gray Institute for Radiation Oncology and Biology, Department of Oncology, University of Oxford, Oxford, - - 2014
Predictive assays are needed to help optimise treatment in muscle-invasive bladder cancer, where patients can be treated by either cystectomy or radical radiotherapy. Our finding that low tumour MRE11 expression is predictive of poor response to radiotherapy but not cystectomy was recently independently validated. Here we investigated further the mechanism ...
Xie Qiang Q Department of - - 2014
Background: Enhancer of Zeste Homolog 2 (EZH2) is a polycomb group protein that has been shown to be involved in the progression of multiple human cancers including melanoma. The expression of EZH2 in normal skin and in pre-malignant and malignant cutaneous squamous cell carcinoma (SCC) has not been studied. Objectives: ...
Seleit Iman I Department of Dermatology, Andrology and STDs, Faculty of Medicine, Menoufiya University, Menoufiya, - - 2014
The etiopathogenetic mechanisms leading to pigment loss in vitiligo are not fully understood. Notch signaling is required for development and maintenance of melanocyte lineage and acts as a key component among keratinocyte-melanocyte interactions. The current study aimed to investigate the possible role of Notch signaling and its effect on the ...
Cardo Lucía F LF Genética Molecular-Laboratorio de Medicina, Hospital Universitario Central de Asturias, Oviedo, - - 2014
Mutations in the alpha-synuclein (SNCA) gene cause autosomal dominant Parkinsońs disease (PD). Common SNCA polymorphisms have been associated with the risk of developing PD. Abnormal expression and post-translational modification of SNCA has been found in PD-brains. In addition to a full length transcript (SNCA-140) there are three short isoforms (SNCA-98, ...
Ubagai Tsuneyuki T Department of Microbiology & Immunology, Teikyo University School of Medicine. Tokyo 173-8605, - - 2014
Objective: In the acute stage of infectious diseases such as pneumonia and sepsis, sequelae hypercytokinemia and cytokine storm are often observed simultaneously. During bacterial infections, activated polymorphonuclear leukocytes (PMNs) cause inflammation and organ dysfunction in severely ill patients. Gene expression of the triggering receptor on myeloid cells (TREM)-1 and G-coupled-protein ...
Ameri Hossein H University of Texas Medical Branch, Galveston, TX, 77555, United - - 2014
Purpose: Retinal neovascularization is a major cause of vision loss in ischemia-induced retinopathy. Tumor necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK) and its receptor, Fn14, have been implicated in angiogenesis but their role in retinal diseases is unknown. The goal of this study was to investigate the role of ...
Sa-Nguanraksa Doonyapat D Graduate Program in Immunology, Department of Immunology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok 10700, - - 2014
Vascular endothelial growth factor (VEGF) is one of the key modulators of angiogenesis. The highly polymorphic promoter and 5' untranslated region of VEGF have been associated with susceptibility to and aggressiveness of several types of cancer. To examine the functional role of VEGF polymorphisms at -634 and -1498 positions, VEGF mRNA ...
Souza-Ferreira Paula S PS Universidade Federal do Rio de Janeiro, Instituto de Bioquímica Médica, Programa de Biologia Molecular e Biotecnologia, 21941-902 Rio de Janeiro, RJ, - - 2014
In a previous study, we found that the embryonic cuticle of Rhodnius prolixus is a chitin-based structure that helps the first instar nymph to hatch from the chorion. Here, we investigated how the reduction of transcripts induced by CHS dsRNA injection affects R. prolixus embryogenesis and eclosion. Deposition of chitin in ...
Das M M Department of Endocrinology and Metabolism, All India Institute of Medical Sciences, New Delhi, - - 2014
OBJECTIVES:We assessed the effect of cholecalciferol and calcium supplementation on mRNA expression of cathelicidin (LL-37), Th1 and Th2 cytokines and their transcription factors in the peripheral blood mononuclear cells (PBMCs) in healthy females with vitamin D deficiency (VDD).SUBJECTS/METHODS:Subjects included 131 females with biochemical VDD randomized to receive (a) oral cholecalciferol ...
Okamoto Takayuki T Department of Pediatrics, Hokkaido University Graduate School of Medicine, Sapporo, - - 2014
Background/Aims: Recent study suggests that activation of parietal epithelial cells (PECs) contributes to pathogenesis of glomerulosclerosis and the activation marker CD44 increases in evolving glomerulosclerosis. Here we examined the pathogenic roles of CD44+ epithelial cells in mouse adriamycin nephropathy (ADRN), a representative rodent model for idiopathic focal segmental glomerulosclerosis (FSGS). ...
Xia Xianyin X Department of Dentistry, the Second Affiliated Hospital of Harbin Medical University, Harbin 150086, - - 2014
Astrocyte elevated gene 1 (AEG-1) expression is up-regulated in various human cancers and plays an important role in tumorigenesis and progression. The aim of this study was to explore AEG-1 expression in oral squamous cell carcinoma (OSCC) and to assess whether it is associated with microvessel density (MVD), metastasis, and ...
Farazi Thalia A - - 2014
Various microRNAs (miRNAs) are up- or downregulated in tumors. However, the repression of cognate miRNA targets responsible for the phenotypic effects of this dysregulation in patients remains largely unexplored. To define miRNA targets and associated pathways, together with their relationship to outcome in breast cancer, we integrated patient-paired miRNA-mRNA expression ...
Zhang Xiao-Mei XM Department of Hematology, Shandong provincial Hospital affiliated to Shandong University, Jinan, - - 2014
The T-cell immunoglobulin and mucin domain-(Tim)-1 molecule and Tim-3 are mainly expressed on activated T helper (Th) 2 and Th1 cells, respectively, and have been implicated in the pathogenesis of some autoimmune diseases. Immune thrombocytopenia (ITP) is a common autoimmune disorder, and the complex dysregulation of cellular immunity has been ...
Sechman Andrzej A Department of Animal Physiology and Endocrinology. Electronic address: - - 2014
The aim of the study was to investigate the in vitro effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on steroid hormone secretion by chicken ovarian follicles and mRNA expression of genes involved in steroids synthesis. In the first in vitro experiment, white (WF) and yellowish (YF) follicles and fragments of the theca (TL) ...
He H H College of Animal Science and Technology, Sichuan Agricultural University, Ya'an 625014, Sichuan, - - 2014
Melatonin (N-acetyl-5-methoxytryptamine), an indole hormone, regulates a variety of important central and peripheral actions related to circadian rhythms and reproduction through its specific receptor subtypes (Mel-1a, Mel-1b and Mel-1c). However, the expression profile of melatonin receptor genes (MTNR1A, MTNR1B and MTNR1C) in ovarian hierarchical follicles of geese remains to be ...
Wang Xiao X Center for Primary Health Care Research, Lund University/Region Skåne, - - 2014
Recent reports suggest that immigrants from Middle Eastern countries are a high-risk group for type 2 diabetes (T2D) compared with Swedes, and that the pathogenesis of T2D may be ethnicity-specific. Deregulation of microRNA (miRNA) expression has been demonstrated to be associated with T2D but ethnic differences in miRNA have not ...
Luo Y Y Department of Dermatology, Hunan Children's Hospital, Changsha, Hunan, - - 2014
Thymic stromal lymphopoietin (TSLP) plays an important role in promoting T-cell homeostasis, and appears to be a central player in the development of allergic symptoms, especially in asthma and atopic dermatitis (AD). Human TSLP is overexpressed in keratinocytes of patients with acute and chronic AD. However, the mechanism of TSLP ...
Choi Jae-Suk JS RIS Center, IACF, Silla - - 2014
The potential hair growth-promoting activity of rice bran supercritical CO2 extract (RB-SCE) and major components of RB-SCE, linoleic acid, policosanol, γ-oryzanol, and γ-tocotrienol, were evaluated with the histological morphology and mRNA expression levels of cell growth factors using real-time reverse transcriptase-polymerase chain reaction (PCR) in C57BL/6 mice. RB-SCE showed hair ...
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