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Luo Xi X Allergy and Cancer Center, Otorhinolaryngology Hospital, The First Affiliated Hospital of Sun Yat-sen University, No. 58, Zhongshan 2nd Road, Guangzhou, 510080, - - 2014
Azelastine was suggested as a supplementary choice of glucocorticoid for the control of moderate to severe allergic rhinitis (AR). However, the underlying mechanism has not been completely understood. In this study, primary cultured nasal epithelial cells and bronchial epithelial cells were stimulated with proinflammatory cytokines (IL-1β and IL-17A) and anti-inflammatory ...
Sennett Rachel R Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, NY, USA; Department of Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, NY, - - 2014
Hair follicle (HF) morphogenesis relies on the coordinated exchange of signals between mesenchymal and epithelial compartments of embryonic skin. Chemokine receptor Cxcr4 expression was recently identified in dermal condensates (DCs) of nascent HFs, but its role in promoting HF morphogenesis remains unknown. Our analyses confirmed Cxcr4 expression in condensate cells, ...
McInnis Elizabeth A EA University of North Carolina Kidney Center, Division of Nephrology and Hypertension, Department of Medicine - - 2014
Proteinase 3 (PR3) and myeloperoxidase (MPO) are two major autoantigens in patients with vasculitis with ANCA. The genes encoding these autoantigens are abnormally expressed in peripheral granulocytes of patients with active ANCA-associated vasculitis. This study provides evidence that this transcriptional dysregulation results in a variety of mRNA processing events from ...
Chen Hong-Yan HY Division of Maternal-Fetal Medicine, Prenatal Diagnosis Center, The First Affiliated Hospital of Guangxi Medical University,6 Shuangyong Road, Nanning, Guangxi, - - 2014
Abstract Objective: To investigate the mRNA and protein expression of FK506-binding protein52 (FKBP52) in the chorionic villi of patients with recurrent spontaneous abortion (RSA) and normal women during early pregnancy. Methods: Fresh chorionic villus tissues were collected from 60 subjects. A total of 30 patients with a history of RSA ...
Narasaraju Telugu T Oklahoma State University, Physiological Sciences Department, Stillwater, Oklahoma, United States ; - - 2014
Rationale. Glycoprotein non-metastatic melanoma protein B (GPNMB) has an important role in tissue repair and angiogenesis. Recently, we have demonstrated that hyperoxia-exposure down-regulates miR-150 expression and concurrent induction of its target gene, GPNMB, in neonatal rat lungs. Objective. This study aims to test the hypothesis that soluble GPNMB (sGPNMB) promotes ...
Aly Rabab M RM Clinical Pathology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt. Electronic address: - - 2014
GRAF is a recognized tumor suppressor gene that was found inactivated in AML. However, the prognostic role of a GRAF transcript has not been studied in patients with AML. In this study, we investigated the expression of the GRAF transcript by real time quantitative PCR in 60 AML patients and ...
Perilli Lisa L Oncology and Immunology Section, Department of Surgery, Oncology and Gastroenterology, University of Padua, Padua, Italy; These authors contributed equally to this - - 2014
MiR-182 expression was evaluated by qRT-PCR and in situ hybridization in 20 tubular adenomas, 50 colorectal carcinoma (CRC), and 40 CRC liver metastases. Control samples obtained from patients with irritable bowel syndrome, or tumor-matched normal colon mucosa were analyzed (n=50). MiR-182 expression increased progressively and significantly along with the colorectal ...
Kim Seong Taeck ST Department of Ophthalmology, Chosun University College of Medicine, Gwangju, - - 2014
To investigate the relationship between plasma TDRD7 mRNA and lens transparency, and to evaluate plasma TDRD7 mRNA as a potential marker for cataracts and its sub-type by quantitatively analyzing human peripheral blood. Plasma RNA was extracted from 40 patients with cataracts, and 30 normal controls of matched age and gender. ...
Motegi Sei-Ichiro SI Department of Dermatology, Gunma University Graduate School of Medicine, Maebashi, - - 2014
Nephrogenic systemic fibrosis (NSF) is characterized by systemic fibrosis and abnormal calcification in patients with severe renal dysfunction. It is considered that gadolinium (Gd)-containing contrast agents used for magnetic resonance imaging trigger the development of NSF. However, the causative role of Gd and the mechanism of Gd-induced fibrosis and calcification ...
Zhang Lu L Inner Mongolia Key Laboratory of Animal Genetics, Breeding and Reproduction, College of Animal Science, Inner Mongolia Agricultural University, Hohhot 010018, - - 2014
MicroRNAs (miRNAs) are an emerging class of regulators that control post-transcriptional processes, and could be potential targets for drug in pathology and potential sites of phenotypic regulation. Although some functions of miRNAs have been known, the regulatory mechanism of miRNAs in skin and hair follicle development remains unclear. High throughput ...
Du Hong-Wu HW School of Chemistry & Biological Engineering, University of Science & Technology Beijing, Beijing, 100083, China, - - 2014
With the development of genomic study, researchers found that it is insufficient to predict protein expression from quantitative mRNA data in large scale, which is contrary to the traditional opinion that mRNA expression correlates with protein abundance at the single gene level. To try to solve the apparent conflicting views, ...
Chen Chung-Huang CH Institute of Cellular and System Medicine, National Health Research Institutes, Zhunan, - - 2014
Vascular smooth muscle cells (VSMCs) of the arterial wall normally display a differentiated and contractile phenotype. In response to arterial injury, VSMCs switch to a synthetic phenotype, contributing to vascular remodeling. Cysteine-rich protein 2 (CRP2) is a cytoskeletal protein expressed in VSMCs and blunts VSMC migration in part by sequestering ...
Gao Pan P Department of Pathology, School of Basic Medical Sciences, Fudan University, 138 Yixueyuan Road, Xuhui District, Shanghai, China. Electronic address: - - 2014
Diabetic nephropathy (DN) is one of the major complications in diabetes patients. Reactive oxygen species (ROS) play key roles in DN progression. As a primary transcription factor, Nrf2 controls the antioxidant response to maintain cellular redox homeostasis. Herein we systemically examined the role of Nrf2 in DN progression and its ...
Vrbacky F - - 2014
Elevated levels of circulating angiogenic cytokines and increased expression of genes encoding angiogenic factors have been reported in recent years in patients with chronic lymphocytic leukemia (CLL) but data regarding prognostic and predictive significance are still limited. Therefore, in the present study based upon our prior pilot results, we measured ...
Qiao Shu-Kai SK Department of Hematology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, China - - 2014
The human cervical cancer oncogene (HCCR) has been shown to be over-expressed in some solid tumors, and its function is involved in negative regulation of p53 tumor suppressor gene. However, the roles of HCCR in leukemia remain unclear. The present study is to investigate whether the expression levels of HCCR ...
Zhou Tian-Biao TB Department of Nephrology, the Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China - - 2014
All-trans retinoic acid (ATRA) exerts various effects on physiological processes such as cell growth, differentiation, apoptosis and inflammation. Prohibitins (PHB), including prohibitin 1 (PHB1) and prohibitin 2 (PHB2), are evolutionary conserved and pleiotropic proteins implicated in various cellular functions, including proliferation, tumor suppression, apoptosis, transcription, and mitochondrial protein folding. The ...
Sun Lidan - - 2014
TAZ is a downstream agent of Hippo signal pathway. beta-catenin is a cell adhesion molecule associated with the invasion and metastasis of carcinomas as well as a critical component of Wnt pathway. TAZ and beta-catenin have long been thought to play a vital role in tumour development and progression. This ...
Ni Fen-Fen FF Shenzhen Institute of Pediatrics, Affiliated Shenzhen Children's Hospital, Chongqing Medical University, Shenzhen 518026, - - 2014
Kawasaki disease (KD) is a type of systemic vasculitis syndrome related to immune dysfunction. Previous studies have implicated that dysfunctional regulatory T cells (Tregs) may be associated with the immune dysfunction in KD. In the absence of microRNAs (miRNAs), Foxp3+ Tregs develop but fail to maintain immune homeostasis. This study ...
Kandratavicius Ludmyla - - 2014
Epilepsy and psychiatric comorbidities are frequently associated, but their common biological substrate is unknown. We have previously reported altered structural elements and neurotrophins (NTs) expression in mesial temporal lobe epilepsy (MTLE) patients with psychiatric comorbidities. NTs receptors can regulate neurotransmission and promote neuroplasticity, being important candidates in the regulation and ...
Xiao Qingli Q Department of Neurology and the Hope Center for Neurological Disorders - - 2014
In sporadic Alzheimer's disease (AD), impaired Aβ removal contributes to elevated extracellular Aβ levels that drive amyloid plaque pathogenesis. Extracellular proteolysis, export across the blood-brain barrier, and cellular uptake facilitate physiologic Aβ clearance. Astrocytes can take up and degrade Aβ, but it remains unclear whether this function is insufficient in ...
Obaid Jamil M A S JM Immunology Department, Medical Research Institute, Alexandria University , Alexandria , Egypt - - 2014
Abstract CD55 is a complement regulatory protein expressed by cells to protect them from bystander lysis by complement. It prevents the formation of C3/C5 convertase. In β-thalassemia (β-thal), the defective hemoglobin (Hb) production makes red blood cells (RBCs) lyse early and frequently. Loss of CD55 expression in those patients compromises ...
Zhan J J 1] Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education, Peking University Health Science Center, Beijing 100191, China [2] State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center, Beijing 100191, China [3] Laboratory of Molecular Cell Biology and Tumor Biology, Department of Anatomy, Histology and Embryology, Peking University Health Science Center, Beijing 100191, - - 2014
Background:Little is known about the tumour suppressive proteins and the underlying mechanisms that suppress colon cancer progression. Homeodomain-containing transcription factor HOXB9 plays an important role in embryogenesis and cancer development. We here aim to uncover the potential role of HOXB9 in the regulation of colon adenocarcinoma progression including epithelial-to-mesenchymal transition.Methods:HOXB9 ...
Li Shuang S Department of Hematology, Huashan Hospital of Fudan University, Shanghai, China; Evidence-Based Medicine Center of Fudan University, Shanghai, - - 2014
The CXXC domain protein 4 (CXXC4) functions as a negative regulator of Wnt signaling and also regulates expression of the ten-eleven translocation 2 (TET2) protein for DNA methylation. This study detected levels of CXXC4 and TET2 mRNA to determine their association with survival of patients with myelodysplastic syndrome (MDS). Levels ...
Pula Bartosz B Department of Histology and Embryology, Medical University of Wroclaw, Chalubinskiego 6a, 50-368, Wroclaw, - - 2014
Metallothionein-3 (MT-3) has been shown to be expressed in several malignancies and to have an impact on patients' survival in breast and urinary bladder cancer cases. However, its expression has not been determined in normal skin or in its malignant lesions. MT-3 expression was studied using immunohistochemistry in 17 cases ...
Hou Xian-Ru XR Department of Ophthalmology, Key Laboratory of Vision Loss and Restoration, Ministry of Education, Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases, People's Hospital, Peking University, Beijing, - - 2014
To determine the expression levels of cytokines, including growth factors, inflammatory cytokines, and cell migration associated factors on the iris from subjects with neovascular glaucoma (NVG). After receiving formal consent from 12 subjects with NVG secondary to proliferative diabetic retinopathy and 12 subjects with primary open angle glaucoma (POAG), trabeculectomy ...
Marchetti M A MA Dermatology Service, Memorial Sloan Kettering Cancer Center, 160 East 53rd Street, 2nd Floor, New York, NY, 10022, - - 2014
BRAF (v-raf murine sarcoma viral oncogene homolog B) V600E mutations have been detected with high frequency in melanocytic naevi. Few studies have stratified analyses by naevus dermoscopic pattern. To determine the frequency of BRAF V600E expression and histopathologic pattern in acquired melanocytic naevi distinguished by a globular v. reticular dermoscopic ...
Dueñas Jiménez J M JM Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico, - - 2014
Estrogens are oncogenic hormones at a high level in breast, prostate, endometrial and lung cancer. Estrogens are synthesized by aromatase which has been used as a biomarker both in breast and lung cancer. Estrogen biological activities are executed by their classic receptors (ERα and ERβ). ERα has been described as ...
Craciun Florin L FL Brigham and Women's Hospital/ Harvard Medical - - 2014
Fibrinogen (Fg) has been implicated in the pathogenesis of several fibrotic disorders by acting as profibrotic ligand for a variety of cellular surface receptors and by modulating the provisional fibrin matrix formed after injury. We demonstrate increased renal Fg expression following unilateral ureteral obstruction and folic acid (FA) nephropathy in ...
Birk Richard R Department of Otorhinolaryngology Head and Neck Surgery, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany - - 2014
The majority of patients affected by chronic rhinosinusitis (CRS) suffer from eosinophilic infiltration. We hypothesised that polihexanide and polyethylene glycol as an antiseptic might alter the eosinophil-associated IL-5 and eotaxin-3 expression in CRS and also the expression of MMP-9, being involved in the tissue-remodelling in CRS. After obtaining samples from ...
Xu Rui-Yi RY Department of Cardiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, - - 2014
Obstructive sleep apnea-hypopnea syndrome (OSAHS) is associated with premature atherosclerosis. However, the associated mechanism remains unknown. This study investigates the expression of adenosine triphosphate (ATP)-binding cassette transporter protein A1 (ABCA1) and cellular cholesterol efflux in cultured macrophages from OSAHS patients. Of the 18 subjects enrolled in this study, six subjects ...
Chen Long - - 2014
Regulatory T cells (Tregs) exhibit functional abnormalities in the context of hepatocellular carcinoma (HCC). The microRNAs (miRNAs) are identified as the key modulators in Tregs. This study was to explore whether the expression profiles of miRNAs of Tregs were different in HCC-activated Tregs and whether Foxp3 had special effects on ...
Jin Yi Y Department of Pathology, The Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, - - 2014
Expressions of Survivin and nuclear factor of kappa light polypeptide gene enhancer in B cells (NF-κB) are associated with a poor prognosis in many malignancies. However, their relationship in hepatocellular carcinoma remains unclear. To investigate the protein expression of Survivin and NF-κB, determine their role in the pathogenesis of hepatocellular ...
Chao Jie J Department of Epidemiology and Health Statistics, Guangdong Key Laboratory of Molecular Epidemiology, Guangdong Pharmaceutical University, 280 Waihuan Road East, Guangzhou, 510010, People's Republic of - - 2014
Tripartite motif-containing 3 (TRIM3) is a member of the tripartite motif (TRIM) protein family and is reported to be involved in the pathogenesis of various cancers. The role of TRIM3 in hepatocellular carcinoma (HCC) is unknown; thus, the goal of this study was to explore the expression level and prognostic ...
Wang Lin L Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, - - 2014
The microRNA miR-155 has been implicated in regulating inflammatory responses and tumorigenesis, but its precise role in linking inflammation and cancer has remained elusive. Here, we identify a connection between miR-155 and Notch signaling in this context. Loss of Notch signaling in the bone marrow (BM) niche alters hematopoietic homeostasis and ...
Li Sufang S Department of cardiology, Peking University People's Hospital, Beijing, - - 2014
The activation of hemostatic system plays a critical role in the incidence of acute coronary events. Haemostatic proteins may be regulated by microRNAs (miRNAs). Microparticles (MPs) are the major carrier of circulating miRNAs. The aim of this study was to determine the potential role of miRNAs in regulating gene expression ...
Zhang Qiurui Q Department of respiratory medicine, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, - - 2014
Viral infection is a significant cause of chronic obstructive pulmonary disease (COPD) and acute exacerbation of COPD. RIG-I-like receptors (RLRs), including RIG-I and MDA-5, are important pattern recognition receptors for viral elimination. The study aims to investigate the role of RIG-I and MDA-5 in COPD pathogenesis. we examined the expression ...
Mao Junhua J Nanjing Medical - - 2014
Abstract Podocytes play a key role in the formation of cellular crescents in experimental and human diseases. However, the underlying mechanisms for podocytes in promoting crescent formation need further investigation. Here we demonstrated that mammalian target of rapamycin complex 1 (mTORC1) signaling was remarkably activated and HIF1alpha expression was largely ...
Tian Xiangguo X Department of Gastroenterology, Provincial Hospital Affiliated to Shandong University, 324 Jingwu Weiqi Road, Jinan, 250021, People's Republic of - - 2014
Intrahepatic cholangiocarcinoma(ICC) is a highly malignant adenocarcinoma arising from bile duct epithelial cells of the intrahepatic biliary system with early hematogenous and lymphatic extrahepatic spread. The current treatment methods for ICC are far from ideal. Identifying novel effective prognostic biomarkers which might be related to the development and progression of ...
Liu Hui H LABioMed at Harbor UCLA Medical Center, Department of Pathology, Torrance, CA 90509, - - 2014
Activation of Toll-like receptor (TLR) signaling which stimulates inflammatory and proliferative pathways is the key element in the pathogenesis of Mallory-Denk bodies (MDBs) in mice fed DDC. However, little is known as to how TLR signaling is regulated in MDB formation during chronic liver disease development. The first systematic study ...
Inoue Yuka Y Department of Biomedical Informatics, Division of health sciences, Osaka University Graduate School of medicine, Yamadaoka 1-7, Suita, Osaka 565-0871, - - 2014
It is important to search the biomarker to predict the development and prognosis of autoimmune thyroid diseases (AITDs), such as Hashimoto's disease (HD) and Graves' disease (GD). MicroRNA (miR) directly bind to the 3' untranslated region of specific target mRNAs to suppress the expression of proteins, promote the degradation of ...
Li Shuo S Tianjin Key Laboratory of Animal and Plant Resistance, College of Life Sciences, Tianjin Normal University, 393 Binshuixidao, Xiqing District, Tianjin 300387, China. Electronic address: - - 2014
Calmodulin (CaM) is a multifunctional calcium sensor protein that participates in various cellular processes under normal, stress and pathological conditions. In crabs, however, the involvement of CaM in response to environmental stress and immune challenges has not been revealed yet. In the present study, a CaM cDNA (EsCaM) was identified ...
Hu Yi-Ming YM Department of Pulmonary Medicine, Affiliated Hospital of Jiangsu University, 438 North Jiefang Street, Zhenjiang, 212001, - - 2014
In a previous study, survivin mRNA expression in non-small cell lung cancer (NSCLC) tissue had been demonstrated to be associated with unfavorable prognosis of patients treated with chemotherapy. In this study, we investigated the survivin mRNA levels in blood of patients with stage IIIA-N2 NSCLC and their association with the ...
Park Se Jin SJ Department of Pediatrics, Ajou University Hospital, Ajou University School of Medicine, Suwon, Korea. - - 2014
Introduction. The aim of our study was to determine whether beta-catenin, a subunit of the cadherin protein complex in the podocyte cytoskeleton, would be altered by hyperglycemia and advanced glycation endproducts (AGE) in glomerular epithelial cells and podocytes in vitro. Materials and Methods. Rat glomerular epithelial cells and mouse podocytes ...
Nagasupriya Alapati - - 2014
The extracellular matrix is a complex integrated system responsible for the physiologic properties of connective tissue. Collagen is the major extracellular component that is altered in pathologic conditions, mainly periodontitis. The destruction involves proteolytic enzymes, primarily matrix metalloproteinases (MMPs), which play a key role in mediating and regulating the connective ...
Li Weiwei W Department of Nephrology, Renal Research Institute, Hunan Key Laboratory of Kidney Disease and Blood Purification, Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. - - 2014
Since it was first described in 1968, immunoglobulin (Ig)A nephropathy (IgAN) has become the most commonly diagnosed form of primary glomerular disease worldwide. A number of reports have shown that toll‑like receptor 9 (TLR9) and B‑cell activating factor (BAFF) may be associated with IgAN; however, sufficient evidence has not yet to ...
Wang Wei W Department of Biliary-Pancreatic Surgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, - - 2014
Farnesoid X receptor (FXR) regulates tumorigenesis, but its clinical significance in gallbladder cancer (GBC) remains unclear. This study investigated its clinical and prognostic significance in GBC patients, as well as its association with the anti-apoptotic protein, myeloid cell leukemia sequence 1 (MCL1) protein. FXR and MCL1 expression in 42 primary ...
Pramod Rc R Department of Oral Pathology and Microbiology, School of Dental Sciences, Krishna Institute of Medical Sciences, Deemed University, Karad, Satara, Maharashtra, - - 2014
Proliferating cell nuclear antigen (PCNA) is a nuclear protein synthesized in the late G1 and S-phase of the cell cycle. Immunodetection of this protein represents a useful marker of the proliferation status of lesions. The aim of this study is to evaluate the immunohistochemical expression of PCNA in oral lichen ...
Zhao Min M State Key Laboratory of Reproductive Medicine, Department of Gynaecology, Wuxi Maternity and Child Health Care Hospital Affiliated to Nanjing Medical University, Wuxi, 214002, - - 2014
Endometriosis is a chronic disease that affects roughly 5-15 % of women of reproductive age. The pathophysiology of the disease occurrence and progression is unclear. MicroRNAs (miRNAs) are short, non-coding RNAs that have important regulatory function. It has been postulated that abnormal expression of miRNA is associated with ovarian endometriosis. Forty ...
Lin Xu X Department of Nephrology, the Affiliated Hospital of Youjiang Medical University for Nationalities, 18 Zhongshan Road, Baise, - - 2014
MiR-155 has been reported to be involved in both innate and adaptive immune responses. But the role of miR-155 in hyperglycemia-induced nephropathy is still unknown. In our current study, 3-month-old male wild-type C57 mice and Mir-155(-/-) mice were used to establish hyperglycemia-induced nephropathy. In our hyperglycemia-induced nephropathy model, the expression ...
Zhou Hongyan H The State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, 54 S Xianlie Road, Guangzhou 510060, - - 2014
Histone deacetylases (HDACs) regulate gene transcription by modifying the acetylation level of histone and nonhistone proteins. In this study, we examined the effect of largazole, an inhibitor of class I HDACs, on inflammatory corneal angiogenesis. In a mouse model of alkali-induced corneal neovascularization (CNV), topical application of largazole to the ...
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