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Liu Ruijie R Departments of Medicine and Nephrology, Mount Sinai School of Medicine, New York, - - 2014
Nuclear factor (NF)-κB and signal transducer and activator of transcription 3 (STAT3) play a critical role in diabetic nephropathy (DN). Sirtuin 1 (Sirt1) regulates transcriptional activation of target genes through protein deacetylation. Here, we determined the roles of Sirt1 and the effect of NF-κB (p65) and STAT3 acetylation in DN. ...
Al Bashir Samir - - 2014
Cysteine- rich secretory protein 3 (CRISP3) prognostic significance in prostate cancer (PCA) has generated mixed result. Herein, we investigated and independently validated CRISP3 expression in relation to ERG and PTEN genomic aberrations and clinical outcome. CRISP3 protein expression was examined by immunohistochemistry using a cohort of patients with localized PCA ...
Punsawad Chuchard - - 2014
Acute kidney injury (AKI) is one of the major complications of Plasmodium falciparum malaria, especially among non-immune adults. It has recently been revealed that activation of transcription factor nuclear factor kappa B (NF-kappaB) induces pro-inflammatory gene expression involved in the development of progressive renal inflammatory diseases. The aim of this ...
Qiao Yun Y Department of Traditional Chinese Medicine, Qilu Hospital, Shandong University, Jinan, 250012, - - 2014
To investigate the mechanism of Panax notoginseng saponins (PNS), an effective component extracted from Panax notoginseng, on atherosclerotic plaque angiogenesis in atherosclerosis-prone apolipoprotein E-knockout (ApoE-KO) mice fed with high-fat, high-cholesterol diet. Twenty ApoE-KO mice were divided into two groups, the model group and the PNS group. Ten normal C57BL/6J mice ...
Zhu Min M From the Neurocognitive Aging Section (MZ, EP, ELS, PRR), and Gene Expression and Genomics Unit (YZ, KGB), National Institutes of Health, National Institute on Aging, Intramural Research Program, Biomedical Research Center, Baltimore, Maryland; and Department of Physiology and Biophysics, Howard University College of Medicine, Washington, DC - - 2014
The detrimental effect of activation of the chemokine CCL4/MIP-1β on neuronal integrity in patients with HIV-associated dementia has directed attention to the potential role of CCL4 expression and regulation in Alzheimer disease. Here, we show that CCL4 mRNA and protein are overexpressed in the brains of APPswe/PS1ΔE9 (APP/PS1) double-transgenic mice, ...
Lotfi Ranya A RA Department of Dermatology and Venereology, Ain Shams University, Cairo, - - 2014
Telomeres are DNA-protein complexes that cap chromosomal ends, promoting chromosome stability. Telomerase is a ribonucleoprotein complex with a direct telomere protective function. Telomere shortening represents lifetime exposure to oxidative stress and is negatively correlated with age, smoking, and mortality. Smoking increases oxidative DNA modification and thus may influence telomere dynamics ...
Mrizak Ines I University of Burgundy, INSERM U866, Faculty of Life Sciences, Dijon, France. - - 2014
Gestational diabetes mellitus (GDM) is pathology of glucose intolerance during pregnancy. It is influenced by maternal hyperglycemia and insulinemia through placental circulation. The study was undertaken to investigate the implication of pro-inflammatory factors in the placenta of GDM women. Thirty GDM women have delivered macrosomic babies, and 30 healthy age-matched ...
Garcia-Esparcia Paula P Institute of Neuropathology, Bellvitge University Hospital, - - 2014
Neuroinflammation is common in neurodegenerative diseases including Parkinson disease (PD), but the extent of the process and their regional differences are not fully documented. Expression of twenty-five mRNAs was assessed with TaqMan-PCR including members of the complement system (C1QL1, C1QTNF7, C3AR1), colony stimulating factors (CYBA, CST7, INPP5D, CSF1R and CSF3R), ...
Imamura Yuko Y *Department of Pharmacology and †Department of Medical Pharmacology, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima, - - 2014
The hypoxia-inducible factors HIF-1α or HIF-2α form heterodimeric complexes with the aryl hydrocarbon receptor nuclear translocator (ARNT). HIF-1α/ARNT and HIF-2α/ARNT complexes activate hypoxia-inducible genes that play critical roles in angiogenesis, anaerobic metabolism, and other processes in response to O2 deprivation. HIF-2α is known to regulate the function and/or differentiation of ...
Overstreet Jessica M JM Center for Cell Biology and Cancer Research, Albany Medical College, 47 New Scotland Avenue Albany, NY - - 2014
Transforming growth factor-β1 (TGF-β1) regulates the tissue response to injury and is the principal driver of excessive scarring leading to fibrosis and eventual organ failure. The TGF-β1 effectors SMAD3 and p53 are major contributors to disease progression. While SMAD3 is an established pro-fibrotic factor, the role of p53 in the ...
Abu-Humaidan Anas H A AH Division of Infection Medicine, Department of Clinical Sciences, Lund University, 221 84 Lund, - - 2014
The complement system is activated in response to tissue injury. During wound healing, complement activation seems beneficial in acute wounds but may be detrimental in chronic wounds. We found that the epidermal expression of many complement components was only increased to a minor extent in skin wounds in vivo and ...
Gao Yan-Xiang YX Department of Cardiology, China-Japan Friendship Hospital, Beijing, P. R. - - 2014
Background/Aims: We investigated the recently described family of proteinases, a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTs), and matrix metalloproteinases (MMPs) as inflammatory mediators in inflammatory kidney damage by studying ADAMTS-1, -4, and -7 and MMP-9 expression in elderly mouse kidneys after angiotensin II (Ang II) administration. Methods: Ang II ...
Martins F S FS Laboratory of Manipulation of Oocytes Enclosed in Preantral Follicles (LAMOFOPA), Veterinary Faculty, State University of Ceará, Fortaleza, - - 2014
This study aimed to demonstrate the expression of growth hormone receptor (GH-R) mRNA and protein in goat ovarian follicles in order to investigate the effects of GH on the survival and development of preantral follicles. The ovaries were processed for the isolation of follicles to study GH-R mRNA expression or ...
Acibucu F F Cumhuriyet University, Endocrinology, Sivas, - - 2014
It has been shown that miRNA 221, 222 and 146b are increasingly expressed while p27Kip1 is suppressed in papillary thyroid cancer (PTC).We investigated the association between the disease recurrence risk and the expression of miRNA 221, 222, 146b and p27Kip1 protein mRNA in these tumors. We also measured the changes ...
Lee Seon-Yeong SY Rheumatism Research Centre, Catholic Research Institute of Medical Science, The Catholic University of Korea, Seoul, - - 2014
We examined the effect of interleukin-17 (IL-17) on the expression of Toll-like receptors (TLRs) in fibroblast-like synoviocytes (FLS) from patients with rheumatoid arthritis (RA) and osteoarthritis (OA). We investigated the region downstream of IL-17 for TLR expression. We also investigated the downstream signals responsible for the effect of IL-17 in ...
Boita Monica M 1Medical Science Department, University of Torino, Torino, - - 2014
The aims of this study were to investigate OX40 ligand expression in sinus tissue from patients with nasal polyposis compared with patients with chronic rhinosinusitis without nasal polyps (NPs), and to determine if OX40 ligand expression is related to eosinophilic sinus infiltration. Twenty patients with chronic rhinosinusitis (11 with and ...
Tivers Michael S MS Department of Veterinary Clinical Sciences, Royal Veterinary College, Hawkshead Lane, North Mymms, Hatfield, Hertfordshire, AL9 7TA, United Kingdom; Cave Veterinary Specialists, George's Farm, West Buckland, Nr. Wellington, TA21 9LE, United Kingdom. Electronic address: - - 2014
Dogs with congenital portosystemic shunts (CPSS) have liver hypoplasia and hepatic insufficiency. Surgical CPSS attenuation results in liver growth associated with clinical improvement. The mechanism of this hepatic response is unknown, although liver regeneration is suspected. This study investigated whether markers of liver regeneration were associated with CPSS attenuation. Dogs ...
Locatelli Monica M IRCCS - Istituto di Ricerche Farmacologiche "Mario Negri," Centro Anna Maria Astori, Bergamo, - - 2014
Shiga toxin (Stx)-producing Escherichia coli is the offending agent of postdiarrhea-associated hemolytic uremic syndrome (HUS), a disorder of glomerular ischemic damage and widespread microvascular thrombosis. We previously documented that Stx induces glomerular complement activation, generating C3a responsible for microvascular thrombosis in experimental HUS. Here, we show that the presence of ...
Min Min M *Department of Gastroenterology and Hepatology, Affiliated Hospital of Academy of Military Medical Sciences, Beijing, China; and †Institute of Digestive Diseases, Chinese PLA General Hospital, Beijing, - - 2014
MicroRNAs (miRNAs) are important posttranscriptional regulators of gene expression. The precise role of miRNAs in ulcerative colitis (UC) is not completely understood. The purpose of this study was to identify miRNAs that are induced in patients with active UC and to assess the effect of miR-155 on improving intestinal inflammation. ...
Lee Ji-Hye JH Department of Pathology, Soonchunhyang University College of Medicine, Cheonan, - - 2014
The purpose of this study was to investigate the expression of urokinase-type plasminogen activator (uPA), uPA receptor (uPAR), and plasminogen activator inhibitor (PAI)-1 on podocytes in immunoglobulin A (IgA) glomerulonephritis (GN). Renal biopsy specimens from 52 IgA GN patients were deparaffinized and subjected to immunohistochemical staining for uPA, PAI-1, and ...
Guinea-Viniegra Juan J F-BBVA-CNIO Cancer Cell Biology Program, Spanish National Cancer Research Centre (CNIO), Madrid 28029, - - 2014
Psoriasis is a common inflammatory skin disease with limited treatment options that is characterized by a complex interplay between keratinocytes, immune cells, and inflammatory mediators. MicroRNAs (miRNAs) are regulators of gene expression and play critical roles in many human diseases. A number of miRNAs have been described to be up-regulated ...
Soerensen-Zender Inga I 1Hannover Medical - - 2014
The aging kidney has a diminished regenerative potential and an increased tendency to develop tubular atrophy and fibrosis after acute injury. In this study, we found that activation of tubular epithelial Notch1 signaling was prolonged in the aging kidney after ischemia/reperfusion (IR) damage. To analyze the consequences of sustained Notch ...
Yi Fu F Xijing Hospital, the Fourth Military Medical University, Xian, - - 2014
The large conductance Ca(2+)-activated K(+) (BK) channel, abundantly expressed in vascular smooth muscle cells (SMCs), is a key determinant of vascular tone. BK channel activity is tightly regulated by its accessory β1 subunit (BK-β1). However, BK channel function is impaired in diabetic vessels by increased ubiquitin/proteasome-dependent BK-β1 protein degradation. The ...
Xu Dekui D Department of Gastroenterology, Zhongshan Hospital of Dalian University, Dalian 116001, P.R. - - 2014
Salvia miltiorrhiza (SM) is mainly used for the treatment of coronary heart disease in China, but previous studies demonstrated that it also shows anti‑inflammatory effects and the underlying mechanisms of these effects are not well understood. The present study aimed to investigate the effect of an injection of SM powder ...
Massa Christopher B CB Department of Pharmacology & Toxicology, Ernest Mario School of Pharmacy, Rutgers - - 2014
Acute Cl2 exposure following industrial accidents or military/terrorist activity causes pulmonary injury and severe acute respiratory distress. Prior studies suggest that antioxidant depletion is important in producing dysfunction, however a pathophysiologic mechanism has not been elucidated. We propose that acute Cl2 inhalation leads to oxidative modification of lung lining fluid, ...
Shi Wei-Lin WL Department of Pulmonary Medicine, Affiliated Hospital of Jiangsu University, 438 North Jiefang Street, Zhenjiang, 212001, - - 2014
The epidermal growth factor receptor (EGFR) mutations have been proven to be a reliable predictive marker for the response to EGFR-tyrosine kinase inhibitors (TKIs) in patients with non-small cell lung cancer (NSCLC). However, the responses to EGFR-TKIs vary even among patients with EGFR mutation. Recent study showed that survivin overexpression ...
Llimona Flávia F Emergency Medicine Department, Faculdade de Medicina, Universidade de São Paulo, Av. Dr. Arnaldo, 455, Room 3189, LIM51, 01246-903, São Paulo, SP, - - 2014
Severe acute pancreatitis (AP) induces a systemic inflammatory disease that is responsible for high mortality rates, particularly when it is complicated by infection. Therefore, differentiating sepsis from the systemic inflammation caused by AP is a serious clinical challenge. Considering the high metabolic rates of leukocytes in response to stress induced ...
Zhou Qihui Q Division of Rheumatology and Clinical Immunology, Medizinische Klinik und Poliklinik IV, University of Munich, Munich, - - 2014
MicroRNAs (miRNAs) have been implicated in the pathogenesis of autoimmune diseases, not least for their critical role in the regulation of regulatory T cell (Treg) function. Deregulated expression of miR-146a and miR-155 has been associated with rheumatoid arthritis (RA). We therefore investigated miR-146a and miR-155 expression in Tregs of patients ...
Monteleone Katia K Pasteur Institute-Cenci Bolognetti Foundation, Department of Molecular Medicine, Laboratory of Virology, Sapienza University of Rome, Viale di Porta Tiburtina n 28, 00185, Rome, - - 2014
Given the growing evidence for a role of interleukin-32 (IL-32) in the immune response to HIV-1 infection and its interplay with type I and III interferons (IFNs), we studied the gene expression of IL-32 isoforms (α and nonα) in untreated chronically HIV-1-infected patients and in gender- and age-matched healthy individuals. ...
Wang Yugang Y Department of Gastroenterology, Shanghai Changning Central Hospital, Shanghai 200336, P.R. - - 2014
The aim of the present study was to investigate the clinical efficacy of phased joint intervention [percutaneous transhepatic variceal embolization (PTVE) + phased partial splenic embolization (PSE)] in patients with portal hypertension complicated by esophageal variceal bleeding and hypersplenism and the effect of this intervention on interleukin-35 (IL-35)/IL-17 expression. A ...
Cakal B B a Department of Microbiology and Clinical Microbiology, Istanbul Medical Faculty , Istanbul University , Istanbul , - - 2014
Abstract In MS patients under IFNβ treatment to seek alternative treatments timely is important that anti-IFNβ antibodies and/or in vivo biologic activity loss detection in these. The most common diagnostic markers used for this purpose are BAb, NAb and MxA.In this study we aimed to establish the availability and feasibility ...
Kim Bongsu B Ophthalmology, The Ohio State University, 400 W 12th Ave, Rm 231, Columbus, OH, 43210, United - - 2014
Purpose: Matrix metalloproteinases (MMPs) and their inhibitors play a role in the pathobiology of retinal detachment (RD) and proliferative vitreoretinopathy (PVR). PVR is facilitated by chronic retinal detachment and involves excessive deposition of extracellular matrix (ECM) proteins. MMP-12 and -13 are important modulators of the ECM which have not been ...
Manuela Cabiati C CNR Institute of Clinical Physiology, Laboratory of Cardiovascular Biochemistry, Pisa, - - 2014
Adrenomedullin (ADM) is a vasodilatory peptide expressed in many tissues. Its levels are elevated in various diseases including chronic heart failure (CHF) and it has been suggested that the up-regulation of ADM in cardiac disease represents a protective mechanism. Similarly, intermedin (IMD), a novel member of the calcitonin/calcitonin gene-related peptide ...
van Impel Andreas - - 2014
In mammals, the homeodomain transcription factor Prox1 acts as the central regulator of lymphatic cell fate. Its restricted expression in a subset of cardinal vein cells leads to a switch towards lymphatic specification and hence represents a prerequisite for the initiation of lymphangiogenesis. Murine Prox1-null embryos lack lymphatic structures, and ...
Soini Ylermi Y Department of Pathology and Forensic Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, School of Medicine, University of Eastern Finland, Cancer Center of Eastern Finland, Kuopio, Finland, - - 2014
We investigated the expression of claudin 5 in 88 ductal adenocarcinomas of the pancreas. The results were correlated with patient prognosis, with claudin 5 expression in blood vessels, with the expression level of bcl2 and bax and with apoptosis. Claudin 5 expression was detected in 24 (38 %) cases. It was ...
Yoon Hyun Kyung HK Department of Dermatology, School of Medicine, Chungnam National University, 266 Munhwa-ro, Jung-gu, Daejeon, 301-747, - - 2014
In this study, we investigated the role of glucocorticoid receptor (GR) in epidermal keratinocytes. In adult normal human skin, GR was highly expressed in the upper layers of the epidermis. Consistent with normal skin, GR expression was increased after calcium treatment of HaCaT keratinocytes cultured in vitro, suggesting that GR ...
Governini Laura L 1Department of Molecular and Developmental Medicine, University of Siena, Siena, - - 2014
The present study investigated expression and protein localization of FOXL2 messenger RNA (mRNA) in endometrium of healthy women and in patients with endometriosis during endometrial cycle. In endometriotic lesions, FOXL2 mRNA and protein were evaluated and a possible correlation with activin A mRNA expression changes was also studied. Endometrium was ...
Zhang Jing J 1] Pediatric Cardiovascular Center, Children's Hospital of Fudan University, Shanghai, China [2] Shanghai Key Laboratory of Prevention and Intervention of Birth - - 2014
Background:As an important component of retinoid acid (RA) signaling pathway, the retinoid x receptor alpha (RXRA) is considered to play important role in the pathogenesis of tetralogy of Fallot (TOF).Methods:The expression level of RXRA mRNA and methylation status of the RXRA promoter region in 26 TOF patients and 6 controls ...
Mezentsev Alexandre A 119991, Moscow, Russia, Gubkina str., bld.3, of.302, Vavilov Institute of General Genetics RAS. Electronic address: - - 2014
This review summarizes the contribution of matrix metalloproteinases to the pathogenesis of psoriasis. In psoriasis, matrix metalloproteinases are involved in the structural changes of the epidermis via the modification of intracellular contacts and the composition of the extracellular matrix, promoting angiogenesis in the dermal blood vessels and the infiltration of ...
Dziunycz Piotr J PJ Department of Dermatology, University Hospital Zurich, Zurich, - - 2014
Cutaneous squamous cell carcinoma (SCC) represents the most important cutaneous complication following organ transplantation. It develops mostly on sun-exposed areas. A recent study showed the role of ATF3 in SCC development following treatment with calcineurin inhibitors. It has been reported that ATF3 which may act as an oncogene, is under ...
Suojalehto Hille H Control of Hypersensitivity Diseases Team, Finnish Institute of Occupational Health, Helsinki, - - 2014
Background: Asthma and allergic rhinitis (AR) commonly coexist and can be taken as manifestations of one syndrome. Evidence exists that microRNAs (miRNAs) are important in controlling inflammatory processes and they are considered promising biomarkers. However, little is known about the differences in miRNA expression in patients with chronic allergic airway ...
Chen Daishi D Department of Otolaryngology-Head and Neck Surgery, Chinese PLA General Hospital, Beijing, - - 2014
Chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by eosinophil-dominant infiltration in Europe and the United States. However, CRSwNP in Asia has shown different immunopathologic features. High-mobility group protein box 1 (HMGB1) is a DNA-binding protein that has been suggested to be involved in various chronic inflammatory diseases. The objective ...
Fraga-Silva R A - - 2014
Angiotensin (Ang)-(1-7), acting through the receptor Mas, has atheroprotective effects; however, its role on plaque vulnerability has been poorly studied. Here, we investigated the expression of the renin-angiotensin system (RAS) components in stable and unstable human carotid plaques. In addition, we evaluated the effects of the chronic treatment with an ...
Panchaprateep R R Division of Dermatology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, - - 2014
Of all the cytokines or growth factors which have been postulated to play a role in hair follicle, insulin-like growth factor-1 (IGF-1) is known to be regulated by androgens. However, how IGF-1 is altered in the balding scalp has not yet been investigated. In this study, expressions of IGF-1 and ...
Taurines Regina R Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University of Wuerzburg, Fuechsleinstraße 15, 97080, Wuerzburg, Germany, - - 2014
Findings from molecular genetic studies and analyses of postmortem and peripheral tissue led to the hypothesis that neurotrophins-as crucial moderators of neuroplasticity-impact on the pathophysiology of autism spectrum disorder (ASD). The study projects aimed to complement former results on the role of brain-derived neurotrophic factor (BDNF), a member of the ...
Yoon Sun-Young SY Department of Dermatology, Seoul National University College of Medicine, Seoul, Republic of Korea; Institute of Human-Environment Interface Biology, Seoul National University Medical Research Center, Seoul, Republic of Korea; Laboratory of Cutaneous Aging and Hair Research, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of - - 2014
The dermal papilla (DP) comprises specialized mesenchymal cells at the bottom of the hair follicle and plays a pivotal role in hair formation, anagen induction and the hair cycle. In this study, DPs were isolated from human hair follicles and serially subcultured. From each subculture at passages 1, 3, and ...
Chu Jessica Y S JY 1School of biological sciences, The University of Hong Kong, Pokfulam, Hong Kong SAR, - - 2014
MicroRNAs (miRNAs) are small, non-coding regulatory RNAs that act as posttranscriptional repressors by binding to the 3' untranslated region (3'UTR) of target genes. They require processing by Dicer, an RNase III enzyme, to become mature regulatory RNAs. Previous work from our laboratory revealed critical roles for miRNAs in nephron progenitors ...
Sakamoto Luis Henrique Toshihiro LH Laboratory of Molecular Pathology of Cancer, Faculty of Health Sciences, University of Brasilia, Brasilia, DF, Brazil; Cell Biology Department, University of Brasilia, Brasilia, DF, Brazil; Jose Alencar Children's Hospital of Brasilia, Brasilia, DF, - - 2014
Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy. Although several clinical characteristics can be associated with worse prognosis, more robust biological markers still remains uncovered. SMYD2, a member of SMYD protein family, regulates the activity of several proteins through methylation. In this study, we performed quantitative real time ...
Dorn Christoph C Department of Internal Medicine I, University Hospital Regensburg, Regensburg, - - 2014
Overnutrition is the major cause of nonalcoholic fatty liver disease (NAFLD) and its advanced form nonalcoholic steatohepatitis (NASH). We aimed to develop and characterize a murine model, which resembles both the pathology and nutritional situation, of NASH patients in Western societies. Mice were fed with a NASH-inducing diet (ND) containing ...
Luchetti Sabina S From the Departments of Neuroimmunology (SL, CGvE, KS, IH), Astrocyte Biology and Neurodegeneration (MEvS), and Neuropsychiatric Disorders (DFS), Netherlands Institute for Neuroscience, an Institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, The - - 2014
The basis of gender differences in the prevalence and clinical progression of multiple sclerosis (MS) is not understood. Here, we identify gender-specific responses in steroid synthesis and signaling in the brains of MS patients as possible contributors to these differences. We investigated gene expression changes in these pathways and of ...
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