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Kannaki T R TR a Indian Veterinary Research Institute , Bareilly , Uttar Pradesh , - - 2015
Toll-like receptors (TLRs), important components of innate immune response, play a pivotal role in early recognition of pathogen as well as in the initiation of robust and specific adaptive immune response. In the present study, the expression profile of chicken TLRs (TLR2A, TLR3, TLR4, TLR5, TLR7, TLR15, and TLR21) in ...
Yabe Tomio T Faculty of Applied Biological Sciences, Department of Applied Life Science, Gifu University, 1-1 Yanagido, Gifu, 501-1193, Japan, - - 2015
In situ hybridization provides information for understanding the localization of gene expression in various tissues. The relative expression levels of mRNAs in a single cell can be sensitively visualized by this technique. Furthermore, since in situ hybridization is a histological technique, tissue structure is maintained after fixation, and it is ...
Lundegard M M Department of Odontology Umeå University SE-901 85 Umeå, Sweden - - 2014
Objectives: Oral Lichen Planus (OLP) is a chronic disease of the oral mucosa, and according to the WHO also a pre malignant condition. Micro-RNAs are short non coding RNAs capable of regulating mRNA expression. MiRNA:scan be detected in tissue, blood and human whole saliva, HWS, and recently we have shown ...
Yuan Jiandong J Department of Orthopedics, The First Affiliated Hospital of Wenzhou Medical College, Wenzhou, 325000, - - 2015
MicroRNA-451 has been proven down-regulated in many human malignancies and correlated with tumor progression. However, its expression and clinical significance in osteosarcoma is still unclear. Thus, the aim of this study was to explore the effects of miR-451 in osteosarcoma tumorigenesis and development. The expression level of miR-451 was quantified ...
Liu Yong Y Department of Gastric Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, 300060, - - 2015
This study aimed to investigate mRNA and protein expressions of SET and MYND domain-containing protein 3 (SMYD3), STAT3, and phosphorylated STAT3 (pSTAT3) in gastric cancer (GC). This study was also conducted to explore the correlations between these proteins and biological behaviors of GC. SMYD3, STAT3, and pSTAT3 expressions were detected ...
de Araujo G G GG Sports Science Research Group - Federal University of Alagoas, UFAL - Maceio AL, Brazil. - - 2014
We evaluate the mRNA expression of monocarboxylate transporters 1 and 4 (MCT1 and MCT4) in skeletal muscle (soleus, red and white gastrocnemius), heart and liver tissues in mice submitted to a single bout of swimming exercise at the maximal lactate steady state workload (MLSSw). After 72 hours of MLSS test, ...
Collier Abby C AC Department of Tropical Medicine, Medical Microbiology and Pharmacology, John A. Burns School of Medicine, University of Hawaii, 651 Ilalo Street, Honolulu, HI, 96813, USA, - - 2014
Placental UDP-glucuronosyltransferase (UGT) enzymes have critical roles in hormone, nutrient, chemical balance and fetal exposure during pregnancy. Placental UGT1A isoforms were profiled and differences between preeclamptic (PE) and non-PE placental UGT expression determined. In third trimester villous placenta, UGT1A1, 1A4, 1A6 and 1A9 were expressed and active in all specimens ...
Li Pei-Nan PN Department of Orthopedic Surgery, First Clinical College, Dalian Medical University, Dalian 116011, - - 2014
Maggot extracts promote wound healing but their bioactive part(s) and molecular effects on the regenerating tissues/cells remain largely unclear. These issues are addressed here by treating rat skin wounds, human keratinocyte line/HaCat and fibroblasts with maggot secretion/excretion and the extracts of maggots without and with secretion/excretion. The wound closure rates, ...
Sun Ren X - - 2014
Research on the aryl hydrocarbon receptor (AHR) has largely focused on variations in toxic outcomes resulting from its activation by halogenated aromatic hydrocarbons. But the AHR also plays key roles in regulating pathways critical for development, and after decades of research the mechanisms underlying physiological regulation by the AHR remain ...
Bartel C C Department of Pathobiology, University of Veterinary Medicine, Institute of Anatomy, Histology and Embryology, Vienna, - - 2014
Hermaphroditism is a rare and a not well-understood disordered sexual development (DSD) in dogs. The objective of the study was to analyse the sex steroid hormone receptor (STHR) expression patterns in the internal genital structures, because the responsiveness of the different tissue types to the steroid hormones may have a ...
Serrano Marta M Department of Diabetes, Endocrinology and Nutrition Institut d'Investigació Biomèdica de Girona (IdIBGi), CIBEROBN (CB06/03/010) and Instituto de Salud Carlos III (ISCIII), Girona, - - 2014
Context: The Coxsackie and Adenovirus Receptor (CAR) was originally identified as a common receptor for coxsackie B viruses and type C adenoviruses Objective: To investigate CAR gene expression in human adipose tissue to explore its associations with adipocyte physiology. Design and Setting: This was an ex vivo study in 91 ...
Hazak Ora O Department of Molecular Biology and Ecology of Plants, Tel Aviv University, Tel Aviv 69978, Israel; - - 2014
Auxin polar transport, local maxima, and gradients have become an important model system for studying self-organization. Auxin distribution is regulated by auxin-dependent positive feedback loops that are not well-understood at the molecular level. Previously, we showed the involvement of the RHO of Plants (ROP) effector INTERACTOR of CONSTITUTIVELY active ROP ...
Liu Zu-Guo ZG Medical College, Eye Institute of Xiamen University, South Xiang'an Road, Xiamen, Fujian, 361102, China - - 2014
Purpose: To investigate the expression pattern and function of survivin in the development of pterygium. Methods: Primary pterygia at quiescent or advanced clinical stage and normal human conjunctival tissues were used in this study. Pterygium epithelial cells (PECs) were cultured in keratinocyte serum-free defined medium and harvested at different growth ...
Drew Brian G BG UCLA David Geffen School of Medicine, United - - 2014
Obesity is associated with increased breast cancer (BrCA) incidence. Considering that inactivation of the estrogen receptor (ER)α promotes obesity and metabolic dysfunction in women and female mice, understanding the mechanisms and tissue-specific sites of ERα action to combat metabolic-related disease, including BrCA, is of clinical importance. To study the role ...
Fu Mei M College of Life Science and Technology, Southwest University for Nationalities, Chengdu, Sichuan 610041, - - 2014
Estrogen and its receptors are essential hormones for normal reproductive function in males and females during developmental stage. To better understand the effect of estrogen receptor (ER) gene in yak (Bos grunniens), reverse transcription-polymerase chain reaction (PCR) was carried out to clone ERα and ERβ genes. Bioinformatics methods were used ...
Ju Jinfen J Department of Gynecology, Nanjing Municipal Organ Hospital, Nanjing, Jiangsu 210018, P.R. - - 2014
Toll-like receptor (TLR) signal transduction is a central component of the primary innate immune response to pathogenic challenge. TLR4, a member of the TLR family, is highly expressed in the endometrial cells of the uterus and could thus be a key link between human chronic endometritis (CE) and the immune ...
Yoshimoto Y Y Laboratory of Reproductive Physiology, Graduate School of Environmental and Life Science, Okayama University, Okayama, - - 2014
The oviduct is an essential organ for successful pregnancy in mammals. The transport of gametes and early embryos is mainly induced by contraction and relaxation of smooth muscle. The contraction and relaxation of bovine oviductal smooth muscle are induced by prostaglandin (PG) F2α and PGE2, respectively. Lysophosphatidic acid (LPA), a ...
Van Hoeck V V São Paulo University, São Paulo, SP, - - 2014
A receptive state of the endometrium is crucial for proper communication with the pre-implantation embryo and, thereby, a perquisite for a successful pregnancy. Both reduction of transmembrane mucin and initiation of apoptotic events have been proposed as key features prompting embryo/endometrial cell interaction and facilitating maternal receptivity of the murine ...
Takahashi H H The United Graduate of Veterinary Sciences Gifu University, Gifu-City, Gifu, - - 2014
Generally, conception is established in the uterine horn ipsilateral to the corpus luteum (CL) in cattle. When a bovine embryo is transferred into the uterine horn contralateral to CL, conception rate is low. Since progesterone (P4) is essential for the establishment of pregnancy in cattle, locational effects of P4 released ...
Andrievskaia Olga O Canadian Food Inspection Agency, Ottawa Laboratory (Fallowfield), 3851 Fallowfield Road, Ottawa, Ontario, Canada K2H 8P9. - - 2014
Contamination of rendered animal byproducts with central nervous system tissues (CNST) from animals with bovine spongiform encephalopathy is considered one of the vehicles of disease transmission. Removal from the animal feed chain of CNST originated from cattle of a specified age category, species-labeling of rendered meat products, and testing of ...
Pan Chenwei C Department of Infectious Disease, The Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, - - 2015
Glypican-3 (GPC3) is a widely used immunohistochemical marker for hepatocellular carcinoma (HCC); however, its prognostic value is unclear. Immunohistochemical evaluation of GPC3 expression was performed on 300 postoperative HCC tissue samples with paired adjacent non-tumor tissues on tissue microarray sections. The integral optic density, representing the expression level of GPC3 ...
Ko Yeoung-Gyu - - 2014
Somatic cell cloning by nuclear transfer (SCNT) in pig is clearly of great benefit for basic research and biomedical applications. Even though cloned offspring have been successfully produced in pig, SCNT is struggling with the low efficiency. In the present study, we investigated differentially expressed proteins of the extraembryonic tissue ...
Wang Yao Y Key Laboratory of Freshwater Aquatic Genetic Resources, Shanghai Ocean University, Huchenghuan Road 999, Shanghai 201306, - - 2014
Connective tissue growth factor (CTGF) is a peptide involved in tissue growth and development, and can be regulated by hypoxia stress. This study aimed to isolate and characterize duplicate Ctgf genes in blunt snout bream Megalobrama amblycephala, and determine their expression patterns and response to hypoxia. Blunt snout bream Ctgfa ...
Bruno Gennaro G Dipartimento di Scienze Biomediche Sperimentali e Cliniche "Mario Serio", Università di Firenze, Viale G,B. Morgagni 50, 50134 Firenze, - - 2014
The matricellular protein connective tissue growth factor (CTGF/CCN2) is recognized as key player in the onset of fibrosis in various tissues, including skeletal muscle. In many circumstances, CTGF has been shown to be induced by transforming growth factor beta (TGFβ) and accounting, at least in part, for its biological action. ...
Chang Ying - - 2014
BackgroundChronic obstructive pulmonary disease (COPD) is an inflammatory disorder marked by relative resistance to steroids. The IL-17 superfamily, which mediates cross-talk between the adaptive and innate immune systems, has been associated with diminished responses to steroids. Increasing evidence supports elevated IL-17 expression in the lung of COPD subjects. However, whether ...
Ohashi Miwa M Graduate School of Agriculture Science, Tohoku University, 1-1 Tsutsumidori-Amamiyamachi, Aoba-ku, Sendai, 981-8555, - - 2014
The development and elongation of active tillers in rice was severely reduced by the lack of cytosolic glutamine synthetase1;2 (GS1;2), and, to a lesser extent, that of NADH-glutamate synthase1 in knock out mutants. In situ hybridization using the basal part of wild type seedlings clearly showed that expression of OsGS1;2 ...
Hou Jian J Key Laboratory of Regenerative Biology, South China Institute of Stem Cell and Regenerative Medicine, Institute of Public Health, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, Guangdong, - - 2014
The aim of this study was to evaluate the expression of DACT1 in human placenta tissue and the relationship between DACT1 and target genes of the Wnt signaling pathway. Real-time PCR and western blotting were used to detect the expression of DACT1 and the target genes of Wnt signaling pathway ...
Scheler Claudia C University of - - 2014
Pectin methylesterase (PME) controls the methylesterification status of pectins and thereby determines the biophysical properties of plant cell walls, which are important for tissue growth and weakening processes. We demonstrate here that tissue-specific and spatio-temporal alterations in cell wall pectin methylesterification occur during the germination of Lepidium sativum. These cell ...
Galmozzi Andrea A Department of Chemical Physiology and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, - - 2014
Obesity develops when energy intake chronically exceeds energy expenditure. Because brown adipose tissue (BAT) dissipates energy in the form of heat, increasing energy expenditure by augmenting BAT-mediated thermogenesis may represent an approach to counter obesity and its complications. The ability of BAT to dissipate energy is dependent on expression of mitochondrial ...
Sonohara Fuminori F Department of Gastroenterological Surgery, Nagoya University Graduate School of Medicine, Nagoya 466-8550, - - 2014
When assessing hepatocellular carcinoma (HCC), it is important to examine prognostic factors in the background normal liver tissue and consider malignant aspects of the primary lesion. Candidate genes were extracted from the background normal liver samples via multiarray analysis. Control samples, termed supernormal (SN) liver, were obtained from 11 cases of ...
Hiyama Masato M Laboratory of Basic Veterinary Science, The United Graduate School of Veterinary Science, Yamaguchi - - 2014
LC3 -the mammalian homolog of Atg8- was found as autophagosome membrane binding protein in mammals and widely used as an autophagosomal marker. LC3A, B and C show different expression patterns in each tissue. The aim of this study was to reveal the differences of expression patterns among LC3 families in ...
Keane Peter P School of Mathematics, Statistics and Applied Mathematics, National University of Ireland - - 2014
The expression of tissue-restricted antigens (TRAs) in the thymus is required to ensure efficient negative selection of potentially auto-reactive T lymphocytes and avoid autoimmune disease. This promiscuous expression is under the control of the autoimmune regulator (AIRE), a transcription factor expressed in medullary thymic epithelial cells (mTECs). Tissue-specific alternative splicing ...
Rajakumar Anbazhagan A Laboratory of Molecular Endocrinology and Reproductive Biology, Department of Animal Biology, School of Life Sciences, Centre for Advanced Studies, University of Hyderabad, Hyderabad, - - 2014
In teleosts, the expression of steroidogenic enzymes and related transcription factor genes occurs in a stage- and tissue-specific manner causing sexual development. The role of sox3, an evolutionary ancestor of SRY, has not been studied in detail. Therefore, the full-length cDNA of sox3 (1,197 kb) was cloned from catfish testis, ...
Boschi Nicole M NM Department of Pharmacology & Physiology, University of Rochester Medical, Center, 601 Elmwood Avenue, Rochester, New York 14642. Electronic address: - - 2014
Polycytosine-binding proteins (PCBPs) are RNA binding proteins that participate in post-transcriptional control pathways. Among the diverse functions of these proteins is the interaction with a 27 nucleotide pyrimidine-rich domain within the 3'UTR of tyrosine hydroxylase (TH) mRNA. Mutations to this domain result in decreased stability of TH mRNA and loss ...
Yamane Takumi T a Faculty of Applied Bioscience, Department of Nutritional Science and Food Safety , Tokyo University of Agriculture , Tokyo , - - 2014
The effects of modern dressings on inflammation, which represent the earliest phase of wound healing, are poorly understood. We investigated the effects of modern hydrocellular foam dressings (HCFs) on wound healing and on the gene expression levels of the inflammatory markers-interleukin (IL)-1β, IL-6, and IL-10-in rat periwound skin and granulation ...
Huang Zhi H ZH University of Chicago, United - - 2014
ApoE is a multi functional protein expressed in several cell types and in several organs. It is highly expressed in adipose tissue where it is important for modulating adipocyte lipid flux and gene expression in isolated adipocytes. In order to investigate a potential systemic role for apoE that is produced ...
Junker Jan Philipp JP Departments of Physics and Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Hubrecht Institute, KNAW, and University Medical Center Utrecht, 3584 CT Utrecht, the - - 2014
Hedgehog signaling controls pattern formation in many vertebrate tissues. The downstream effectors of the pathway are the bifunctional Gli transcription factors, which, depending on hedgehog concentration, act as either transcriptional activators or repressors. Quantitatively understanding the interplay between Gli activator and repressor forms for patterning complex tissues is an open ...
Jain Buddhi Prakash BP School of Life Sciences, Jawaharlal Nehru University, New Delhi 110067, - - 2014
SG2NA belongs to a three member Striatin subfamily of WD-40 repeat superfamily. It has multiple protein-protein interaction domains that are involved in the assembly of supra-molecular signaling complexes. Earlier we had demonstrated that there are at least five variants of SG2NA, generated by alternative splicing. We now demonstrate that a ...
Sinreih Maša M Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Ljubljana, - - 2014
Endometriosis is a frequent benign gynecological disease characterized by endometrial tissue outside the uterine cavity. The estimated prevalence in the general population is 6-10%, but this reaches 30-50% in women with infertility and/or pain. As ectopic tissue within the pelvic cavity provokes inflammation, endometriosis is also considered a chronic inflammatory ...
Yang Hua H Respiratory Department, Yantai Hospital of Traditional Chinese Medicine, No. 39, Xingfu Road, Zhifu District, Yantai, 264002, - - 2014
It has been reported that protein phosphatase, Mg(2+)/Mn(2+) dependent, 1D (PPM1D) plays an important role in cancer tumorigenesis. However, the clinical and functional significance of PPM1D expression has not been characterized previously in non-small cell lung cancer (NSCLC). The purpose of this study was to assess PPM1D expression and to ...
Lin Shin S Department of Genetics, Stanford University, Stanford, CA 94305; Division of Cardiovascular Medicine, Stanford University, Stanford, CA - - 2014
Although the similarities between humans and mice are typically highlighted, morphologically and genetically, there are many differences. To better understand these two species on a molecular level, we performed a comparison of the expression profiles of 15 tissues by deep RNA sequencing and examined the similarities and differences in the ...
Chen Xi X Department of Otolaryngology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, - - 2014
Objective: To evaluate the regulatory effect of corticosteroid on occludin expression in polyp tissues of chronic rhinosinusitis with nasal polyps (CRSwNP) patients and in vitro. Methods: Twenty CRSwNP patients were enrolled and subjected to prednisone (30 mg/day for 14 days). The expression of occludin in polyp tissues was examined before ...
Burk Janina - - 2014
Multipotent mesenchymal stromal cells (MSC) can be recovered from a variety of tissues in the body. Yet, their functional properties were shown to vary depending on tissue origin. While MSC have emerged as a favoured cell type for tendon regenerative therapies, very little is known about the influence of the ...
Sinha Tanvi T Department of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, United - - 2014
Planar cell polarity (PCP) signaling is an evolutionarily conserved mechanism that coordinates polarized cell behavior to regulate tissue morphogenesis during vertebrate gastrulation, neurulation and organogenesis. In Xenopus and zebrafish, PCP signaling is activated by non-canonical Wnts such as Wnt11, and detailed understanding of Wnt11 expression has provided important clues on ...
Li Hong-Dong HD Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, - - 2014
Canonical isoforms in different databases have been defined as the most prevalent, most conserved, most expressed, longest, or the one with the clearest description of domains or posttranslational modifications. In this article, we revisit these definitions of canonical isoforms based on functional genomics and proteomics evidence, focusing on mouse data. ...
Gilet Alexandre A University of Lorraine, UMR_S U1116 (ex-U961 UHP-INSERM), Vandoeuvre-les-Nancy, - - 2014
Aldosterone and mineralocorticoid receptors are important regulators of inflammation. During this process, chemokines and extracellular matrix degradation by matrix metalloproteases, such as MMP-9, help leukocytes reaching swiftly and infiltrating the injured tissue, two processes essential for tissue repair. Leukocytes, such as neutrophils, are a rich source of MMP-9 and possess ...
Latimer Jean J JJ Department of Pharmaceutical Sciences, College of Pharmacy, Nova Southeastern University, Fort Lauderdale, - - 2014
Nucleotide excision repair (NER) is important as a modulator of disease, especially in constitutive deficiencies, such as the cancer predisposition syndrome Xeroderma pigmentosum. We have found profound variation of NER capacity among normal individuals, between cell-types and during carcinogenesis. NER is a repair system for many types of DNA damage, ...
Zhang Fei F Department of Orthopedics, Ningbo Development Zone Center Hospital, Ningbo, 315800, - - 2014
Recent studies have shown that microRNA-451 (miR-451) was significantly decreased in osteosarcoma tissues and was identified as a tumor suppressor in other types of human cancers. However, its clinical significance and molecular mechanisms in osteosarcoma are still not well understood. MiR-451 levels are evaluated by quantitative reverse transcription-polymerase chain reaction ...
Xue Tian T Faculty of Life Science, Northwest University, Xi'an, Shaanxi 710069, P.R. - - 2014
Human aspartyl-(asparaginyl)-β-hydroxylase (HAAH) is a type 2 transmembrane protein and an α-ketoglutarate-dependent dioxygenase that can stereospecifically catalyze the post-translational hydroxylation reaction of β-carbon atoms of aspartic acid and asparagine residues present in epidermal growth factor-like domains of certain specific proteins. Humbug is a truncated isoform of aspartyl (asparaginyl) β-hydroxylase that lacks the ...
Chen Dong D Department of Pediatric Surgery, Shengjing Hospital of China Medical University, Liaoning 110004, P.R. - - 2014
Hirschsprung's disease (HSCR) is a congenital disorder characterized by an absence of enteric ganglion cells in the terminal regions of the gut during development. To date, the cause of HSCR remains unclear, although the pathogenesis of this complex disease is hypothesized to be influenced by numerous genetic and environmental factors. ...
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