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Krause J S JS Department of Neurobiology, Physiology and Behaviour, University of California, One Shields Avenue, Davis, CA, 95616, - - 2014
The acute stress response in vertebrates is a highly adaptive suite of physiological and behavioural mechanisms that promote survival in the face of deleterious stimuli from the environment. Facultative changes of physiology and behaviour are mediated through changes in circulating levels of glucocorticoids (corticosterone, cortisol) and their subsequent binding to ...
Telonis-Scott Marina M School of Biological Sciences, Monash University, Clayton, 3800, Victoria, - - 2014
The cellular stress response has long been the primary model for studying the molecular basis of thermal adaptation, yet the link between gene expression, RNA metabolism and physiological responses to thermal stress remains largely unexplored. We address this by comparing the transcriptional and physiological responses of three geographically distinct populations ...
Yu Yuan Y Department of Nephrology, The Second Affiliated Hospital, Chongqing Medical University, Chongqing 400010, P.R. - - 2014
Elevated plasma low‑density lipoprotein (LDL) is associated with systemic inflammation, and is an important factor in the pathogenesis of chronic kidney disease. The aim of the present study was to investigate the effects of endoplasmic reticulum (ER) stress preconditioning on LDL‑induced inflammatory responses, in human mesangial cells (HMCs). HMCs were ...
Lee Schuyler S University of Colorado-Boulder, United - - 2014
Mutations in several genes, including PINK1 and Parkin, are known to cause autosomal recessive cases of Parkinsons disease in humans. These genes operate in the same pathway and play a crucial role in mitochondrial dynamics and maintenance. PINK1 is required to recruit Parkin to mitochondria and initiate mitophagy upon mitochondrial ...
Taniguchi Mai M Department of Molecular Biochemistry, Graduate School of Life Science, University of - - 2014
The Golgi stress response is a mechanism by which, under conditions of insufficient Golgi function (Golgi stress), the transcription of Golgi-related genes is upregulated through an enhancer, the Golgi apparatus stress response element (GASE), in order to maintain homeostasis in the Golgi. The molecular mechanisms associated with GASE remain to ...
Feidantsis Konstantinos K Laboratory of Animal Physiology, Department of Zoology, Faculty of Science, School of Biology, Aristotle University of Thessaloniki, 54124, Thessaloniki, - - 2014
The present study assesses the resilience of the Mediterranean gilthead seabream (Sparus aurata) to acute warming and water acidification, using cellular indicators of systemic to molecular responses to various temperatures and CO2 concentrations. Tissue metabolic capacity derived from enzyme measurements, citrate synthase, 3-hydroxyacyl CoA dehydrogenase (HOAD), as well as lactate ...
Bradley Elizabeth W EW Mayo Clinic, United - - 2014
Histone deacetylases (Hdacs) regulate endochondral ossification by suppressing gene transcription and modulating cellular responses to growth factors and cytokines. We previously showed that Hdac7 suppresses Runx2 activity and osteoblast differentiation. In this study, we examined the role of Hdac7 in postnatal chondrocytes. Hdac7 was highly expressed in proliferating cells within ...
Bae Seunghee S Molecular-Targeted Drug Research Center and Korea Institute for Skin and Clinical Sciences, Konkuk University, Seoul 143-701, Republic of - - 2014
Exposure to high-dose ionizing radiation, including γ-radiation, induces severe skin disorders. However, the biological consequences and molecular mechanisms responsible for the response of human skin to low-dose γ-radiation (LDR) are largely unknown. In the present study, we demonstrate that LDR (0.1 Gy) induces distinct cellular responses in normal human dermal fibroblasts (NHDFs) ...
Li Zong-Zhuang ZZ Department of Cardiology, Shanghai First People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200080, - - 2014
The ability of nicotine to induce aortic aneurysms has been shown in animal models; however, its underlying mechanisms remain elusive. In the present experiment, both the RAW264.7 and MOVAS cell lines were employed to examine the nicotine-induced modulation of VCAM-1, MMP-2, and MMP-9 expressions in macrophages and vascular smooth muscle ...
Zhu Lili L Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes of Biological Sciences Chinese Academy of Sciences/Shanghai JiaoTong University School of Medicine, Shanghai, - - 2014
Pluripotency-associated transcription factor Foxd3 is required for maintaining pluripotent cells. However, molecular mechanisms underlying its function are largely unknown. Here, we report that Foxd3 suppresses differentiation induced by calcineurin-NFAT signaling to maintain the ESC identity. Mechanistically, Foxd3 interacts with NFAT proteins and recruits co-repressor Tle4, a member of the Tle ...
Yu Shibing - - 2014
Transcription factor activating protein 2 (AP2) plays an important role in cellular differentiation. Although profound craniofacial and long bone developmental abnormalities have been observed in AP2 knockout mice, the molecular effects of AP2 on osteoblasts are poorly defined. We demonstrated that AP2 regulates the expression of human frizzled 1 (FZD1), ...
Rubin Katarina A L KA AstraZeneca R&D Molndal - - 2014
Abstract The suppression of hepatic Cytochrome P450 (P450) expression during inflammatory and infectious diseases and the relief of this suppression by successful disease treatment have been previously demonstrated to impact drug disposition. To address this clinically relevant phenomenon preclinically, the effect of pro-inflammatory cytokines on P450 isoenzymes in human hepatocytes ...
Pellizzaro Anthoni A University of - - 2014
Elongation of the primary root during post germination of Medicago truncatula seedlings is a multigenic trait responsive to exogenous nitrate. Quantitative trait loci approach suggested the involvement of the nitrate transporter MtNPF6.8 in the inhibition of primary root elongation by high exogenous nitrate. In the present work, the inhibitory effect ...
Filichkin Sergei A SA Department of Botany and Plant Pathology, Oregon State University, Corvallis, Oregon, 97331, USA Center for Genome Research and Biocomputing, Oregon State University, Corvallis, Oregon, 97331, USA - - 2014
Environmental stresses profoundly altered accumulation of nonsense mRNAs including intron retaining (IR) transcripts in Arabidopsis. Temporal patterns of stress-induced IR mRNAs were dissected using both oscillating and non-oscillating transcripts. Broad range thermal cycles triggered a sharp increase in the long intron retaining CCA1 isoforms and altered their phasing to different ...
Chauhan S S SS Department of Animal Husbandry, Government of Himachal Pradesh, Shimla 171005, India Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, Vic 3010, - - 2014
The objective of this study was to investigate the effects of chronic heat (thermal) stress and dietary antioxidant supplementation on the expression of heat shock proteins and inflammatory genes in the skeletal muscle of sheep. Twenty-four Merino × Poll Dorset crossbred ewes were allocated to either a control (10 IU ...
Crambert Gilles G UPMC/INSERM/Paris Descartes U1138 CNRS ERL 8228, Equipe 3 Métabolisme et Physiologie Rénale, Centre de Recherche des Cordeliers, Paris, - - 2014
Large shifts of osmolality occur in the kidney medulla as part of the urine concentrating mechanism. Hyperosmotic stress profoundly challenges cellular homeostasis and induces endoplasmic reticulum (ER) stress. Here, we examined the unfolded protein response (UPR) in hyperosmotically-challenged principal cells of the kidney collecting duct (CD) and show its relevance ...
- - 2014
[This corrects the article DOI: 10.1371/journal.ppat.1004487.].
Dangi Satyaveer Singh SS Physiology and Climatology, Indian Veterinary Research Institute, Izatnagar, Bareilly, Uttar Pradesh, 243122, - - 2014
Menacing global rise in surface temperature compelled more focus of research over understanding heat stress response mechanism of animals and mitigation of heat stress. Twenty-four goats divided into four groups (n = 6) such as NHS (non-heat-stressed), HS (heat-stressed), HS + VC (heat-stressed administered with vitamin C), and HS + VE + Se (heat-stressed administered with vitamin E ...
Binkert Melanie M Department of Botany and Plant Biology, University of Geneva, Sciences III, CH-1211 Geneva 4, - - 2014
In plants subjected to UV-B radiation, responses are activated that minimize damage caused by UV-B. The bZIP transcription factor ELONGATED HYPOCOTYL5 (HY5) acts downstream of the UV-B photoreceptor UV RESISTANCE LOCUS8 (UVR8) and promotes UV-B-induced photomorphogenesis and acclimation. Expression of HY5 is induced by UV-B; however, the transcription factor(s) that ...
Liu Ying Y Shandong Provincial Key Laboratory of Water Pollution Control and Resource Reuse, School of Environmental Science and Engineering, Shandong University, Jinan, 250100, People's Republic of China, - - 2014
The responses of Microcystis aeruginosa under exposure to spiramycin and amoxicillin were investigated on both cellular and genetic levels through a 7-day exposure test. Algal growth was inhibited by spiramycin while promoted by amoxicillin at test concentrations of 0.6-1.8 μg L(-1), indicating a higher toxicity of spiramycin than amoxicillin. During the whole ...
Yuan Chao C Key Laboratory for Molecular Animal Nutrition of Ministry of Education, Feed Science Institute, College of Animal Science, Zhejiang University (Zijingang Campus), Hangzhou, 310058, - - 2014
L-arginine (L-Arg) uptake is mediated by members of cationic amino acid transporter (CAT) family and may coincide with the induction of nitric oxide synthases (NOS). The present study was conducted to investigate the extracellular concentrations of L-Arg regulating the CAT-1, CAT-4 and inducible NOS (iNOS) in chick intestinal epithelial cells. ...
Kee Hae Jin HJ Cardiovascular Convergence Research Center, Chonnam National University Hospital, Gwangju, 501-757, South - - 2014
Sulforaphane is a naturally occurring isothiocynate compound found in cruciferous vegetables. Here we report the effect of sulforaphane on cardiac hypertrophy and propose an underlying mechanism. Sulforaphane suppresses cardiomyocyte hypertrophy induced by hypertrophic stimuli in vitro and in vivo. Sulforaphane suppresses the expressions of fetal genes, including ANP, BNP, and ...
Takahashi Hideyuki H Iwate Biotechnology Research Center, Kitakami, Iwate 024-0003, Japan - - 2014
Bud dormancy is an adaptive strategy that perennials use to survive unfavorable conditions. Gentians (Gentiana), popular alpine flowers and ornamentals, produce overwintering buds (OWBs) that can persist through the winter, but the mechanisms regulating dormancy are currently unclear. In this study, we conducted targeted metabolome analysis to obtain clues about ...
Hu Li-Fang LF Key Laboratory for Space Bioscience and Biotechnology, Institute of Special Environmental Biophysics, School of Life Sciences, Northwestern Polytechnical University, Xi'an, 710072, - - 2014
Microgravity decreases the differentiation of osteoblast. However, as this process is multistage and complex, the mechanism by which microgravity inhibits osteoblast differentiation is still unclear. We have previously found that 24 h acute treatment of simulated microgravity (SM) in a random positioning machine (RPM) significantly inhibited the differentiation of preosteoblasts and ...
Takii Ryosuke R Department of Biochemistry and Molecular Biology, Yamaguchi University School of Medicine, Minami-Kogushi 1-1-1, Ube 755-8505, - - 2014
The Heat shock response is an evolutionally conserved adaptive response to high temperatures that controls proteostasis capacity, and is mainly regulated by an ancient heat shock factor (HSF). However, regulation of the stress-inducible HSF1 transcription complex on target genes has not yet been examined in detail in mammalian cells. In ...
Kang Hojin H Division of Pharmacology, Department of Molecular Cell Biology, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Suwon, Gyeonggi-do 440-746, Republic of - - 2014
The nucleolus is a compartment for the transcription of ribosomal RNA (rRNA) and assembly of ribosome subunits. Dysregulation of the nucleolus is considered to be a cellular stress event associated with aging and neurodegenerative disease, including Parkinson's disease (PD). We previously demonstrated that PARIS (PARkin Interacting Substrate, ZNF746) transcriptionally suppresses ...
Ricciardi Carolyn J CJ Department of Nutrition, University of Tennessee, 1215 W. Cumberland Ave, Knoxville, TN, 37996, - - 2014
The vitamin D system plays a role in metabolism regulation. 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) suppressed 3T3-L1 white adipocyte differentiation. Vitamin D receptor (VDR) knockout mice showed increased energy expenditure, whereas mice with adipose-specific VDR over-expression showed decreased energy expenditure. Brown adipose tissue (BAT), now known to be present in adult humans, ...
Hosokawa Mai M Department of Psychiatry, Course of Integrated Brain Sciences, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima, - - 2014
The aim of this study is to examine the hemodynamic changes induced by cognitive process of facial expression by using multichannel near-infrared spectroscopy (NIRS) in healthy subjects with varying degree of autism tendency. Subjects were 38 volunteers, 20 males and 18 females. Autism tendency was measured by the Autism Spectrum ...
Zimmer Cédric C School of Psychology and Neuroscience, University of St Andrews, St Andrews, United Kingdom, KY16 - - 2014
Stress exposure during early life development can program individual brain and physiology. The hypothalamic-pituitary-adrenal (HPA) axis is one of the primary targets of this programming which is generally associated with a hyperactive HPA axis, indicative of a reduced negative feedback. This reduced feedback efficiency usually results from a reduced level ...
Arcidiacono Maria Vittoria MV Renal Division, Washington University School of Medicine, St. Louis, MO, USA Division of Experimental Nephrology, IRB Lleida, Lleida, - - 2014
In secondary hyperparathyroidism (SHPT), enhanced parathyroid levels of transforming growth factor-α (TGFα) increase EGF receptor (EGFR) activation causing parathyroid hyperplasia, high parathyroid hormone (PTH) and also reductions in vitamin D receptor (VDR) that limit vitamin D suppression of SHPT. Since anti-EGFR therapy is not an option in human SHPT, we ...
Cheng Xin X Department of Histology & Embryology, Key Laboratory for Regenerative Medicine of the Ministry of Education, School of Medicine, Jinan University, Guangzhou 510632, - - 2014
Dexamethasone (Dex) has anti-inflammatory and immunomodulatory properties against many conditions. There is a potential teratogenic risk, however, for pregnant women receiving Dex treatment. It has been claimed that Dex exposure during pregnancy could affect osteogenesis in the developing embryo, which still remains highly controversial. In this study, we employed chick ...
Fu Zidong Donna ZD University of Kansas Medical Center, United - - 2014
Statins are effective cholesterol-lowering drugs to treat cardiovascular diseases. Bile acids (BAs), the end products of cholesterol metabolism in liver, are important nutrient and energy regulators. The present study aims to investigate how statins affect BA homeostasis in the enterohepatic circulation. Male C57BL/6 mice were treated with atorvastatin (100 mg/kg/day ...
España Laura L IHSM - - 2014
Tomato (Solanum lycopersicum L.) fruit ripening is accompanied by an increase in chalcone synthase (CHS) activity and flavonoid biosynthesis. Flavonoids accumulate in the cuticle giving its characteristic orange color that contributes to the eventual red color of the ripe fruit. Using virus-induced gene silencing (VIGS) in fruits we have down-regulated ...
Arakawa Keiko K Department of Psychology, State University of New York at Binghamton, Binghamton, N.Y., - - 2014
Exposure to stressors such as footshock leads to increased expression of multiple inflammatory factors, including the pro-inflammatory cytokine interleukin-1 (IL-1) in the brain. Studies have indicated that there are sex differences in stress reactivity, suggesting that the fluctuation of gonadal steroid levels across the estrous cycle may play a regulatory ...
Yoshizaki Norihiro N Advanced Technology Research Laboratory, NOF Corporation, - - 2014
Ultraviolet light (UV) induces an inflammatory response in the skin by cyclooxygenase (COX)-2 expression and prostaglandin (PG) E2 production. Citrus peel has been used as a natural medicine. It contains polymethoxyflavonoids (PMFs) as a major ingredient, which have anti-inflammatory activity. We obtained orange peel extract containing high levels of PMFs. ...
Hua Xia X Ocular Surface Center, Cullen Eye Institute, Department of Ophthalmology, Baylor College of Medicine , Houston, TX , USA - - 2014
Abstract Purpose: To explore the effects of osmoprotectants on pro-inflammatory mediator production in primary human corneal epithelial cells (HCECs) exposed to hyperosmotic stress. Methods: HCECs cultured in iso-osmolar medium (312 mOsM) were switched to hyperosmotic media with or without prior incubation with 2-20 mM of l-carnitine, erythritol or betaine for different ...
Campbell Michael M Penn State Erie, The Behrend College, School of Science, 4205 College Drive, Erie, PA, 16563, USA, - - 2014
Perennial plants undergo repression of meristematic activity in a process called dormancy. Dormancy is a complex metabolic process with implications for plant breeding and crop yield. Endodormancy, a specific subclass of dormancy, is characteristic of internal physiological mechanisms resulting in growth suppression. In this study, we examine transcriptional changes associated ...
Ma Biao B State Key Lab of Plant Genomics, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, - - 2014
Ethylene and abscisic acid (ABA) have a complicated interplay in many developmental processes. Their interaction in rice is largely unclear. Here, we characterized a rice ethylene-response mutant mhz4, which exhibited reduced ethylene-response in roots but enhanced ethylene-response in coleoptiles of etiolated seedlings. MHZ4 was identified through map-based cloning and encoded ...
Gao Lin L Department of Surgery and Biomedical Engineering, Beckman Laser Institute and Medical Clinic, University of California, Irvine, 92612, California; Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, - - 2014
Administration of topical rapamycin (RPM) suppresses the regeneration and revascularization of photocoagulated blood vessels induced by pulsed dye laser (PDL). To systematically elucidate the molecular pathophysiology of the inhibition of PDL-induced angiogenesis by topical RPM in a rodent model. The mRNA expression profiles of 86 angiogenic genes and phosphorylation levels ...
Saul Nadine N Department of Biology, Freshwater and Stress Ecology, Humboldt-Universität zu Berlin, Späthstr. 80/81, 12437 Berlin, Germany. Electronic address: - - 2014
Cyanobacterial blooms in aquatic environments are frequently characterized by elevated levels of microcystins, a potent hepatotoxin. Here we exposed the nematode Caenorhabditis elegans with environmentally realistic concentrations of MC-LR to explore its non-hepatic toxicity. Lifespan, reproduction and growth assays confirmed the toxic potential of 100μg/L MC-LR even in this liver-lacking ...
Zhang Yu-Fei - - 2014
Only occupying about 1%-5% of total testicular cells, the adult Leydig cell (ALC) is a unique endocrine cell that produces androgens. Rat Leydig cells regenerate after these cells in the testis are eliminated with ethane dimethane sulfonate (EDS). In this study, we have characterized Leydig cell regeneration and messenger ribonucleic ...
Zhen He H Hubei Key Laboratory of Genetic Regulation and Integrative Biology, College of Life Sciences, Central China Normal University, Wuhan, 430079, - - 2014
In order to explore the impact of mercury on fish, zebrafish were exposed in various levels of HgCl2 and the superoxide dismutase (SOD), acetylcholinesterase (AChE) activities were measured after 1 and 7 days exposure. Muscle RNA was also extracted for semi-quantitative RT-PCR determination of the expression of AChE, CYP1A1, Cu/Zn-SOD. It ...
Park Kyung Soo KS Department of Immunology, University of Pittsburgh, Pittsburgh, PA 15261; - - 2014
Differentiation of B cells into Ab-secreting cells induces changes in gene transcription, IgH RNA processing, the unfolded protein response (UPR), and cell architecture. The transcription elongation factor eleven nineteen lysine-rich leukemia gene (ELL2) stimulates the processing of the secreted form of the IgH mRNA from the H chain gene. Mice ...
Majerciak Vladimir V Tumor Virus RNA Biology Section, Gene Regulation and Chromosome Biology Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland 21702, - - 2014
Kaposi sarcoma-associated herpesvirus (KSHV) ORF57 is a multifunctional post-transcriptional regulator essential for viral gene expression during KSHV lytic infection. ORF57 requires interactions with various cellular proteins for its function. Here, we identified serine/arginine-rich splicing factor 3 (SRSF3, formerly known as SRp20) as a cellular cofactor involved in ORF57-mediated splicing of ...
Choi Jae-Ho JH 1 Department of Food Science and Biotechnology, College of Agriculture and Life Sciences, Kangwon National University , Chuncheon, - - 2014
Abstract Sasang constitutional medicine is a major branch of Korean traditional oriental medicine. Constitutions of Sasang medicine are classified into Taeyangin, Taeumin, Soyangin, and Soumin. We investigated immunostimulatory activities of fermented soybean product (FSP) extracts and their major bioactive compounds, isoflavone glycosides in primary immune cells isolated from the blood ...
Li Wei W Howard Hughes Medical Institute, Department of Molecular Biology, Princeton University, Princeton, NJ 08544, - - 2014
In Drosophila melanogaster, the anteroposterior (AP) and dorsoventral (DV) axes of the oocyte and future embryo are established through the localization and translational regulation of gurken (grk) mRNA. This process involves binding of specific factors to the RNA during transport and a dynamic remodeling of the grk-containing ribonucleoprotein (RNP) complexes ...
Zhu Bin B College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi 712100, - - 2014
Trifloxystrobin (TFS) is the widely used strobilurin fungicide. However, little information is so far available regarding the uptake kinetics and developmental toxicity of TFS to fish. The present study was conducted to investigate the uptake kinetics, potential environment risk and toxicity of TFS on Gobiocypris rarus embryos. Results revealed that ...
Yang Heping H University of Southern Calfornia, Keck School of Medicine, Division of Gastroenterology and Liver Diseases, USC Research Center for Liver Diseases, Los Angeles , California, United States ; - - 2014
Aims: We showed chronic cholestatic liver injury induced the expression of c-Myc but suppressed that of glutamate-cysteine ligase (GCL, composed of catalytic and modifier subunits GCLC and GCLM, respectively). This was associated with reduced nuclear antioxidant response element (ARE) binding by nuclear factor-erythroid 2 related factor 2 (Nrf2). Here we ...
Piesiewicz Aneta A Department of Animal Physiology, Faculty of Biology, University of Warsaw , - - 2014
Previously, we have demonstrated the postembryonic development of chicken (Gallus gallus domesticus L.) pineal gland functions expressed as changes in melatonin (MEL) biosynthesis. Pineal concentrations of MEL and its precursor serotonin (5-HT) were shown to increase between the 2nd and 16th day of life. We also found that levels of ...
Li Jie J Center for Theoretical and Applied Neuro-Oncology, Division of Neurosurgery, University of California, San Diego. Contributed equally to this - - 2014
The intrinsic signaling cascades and cell states associated with the Glioma CpG Island Methylator Phenotype (G-CIMP) remain poorly understood. Using published mRNA signatures associated with EGFR activation, we demonstrate that G-CIMP+ tumors harbor decreased EGFR signaling using three independent datasets, including the Chinese Glioma Genome Atlas(CGGA; n=155), the REMBRANDT dataset ...
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