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Takahashi Hideyuki H Iwate Biotechnology Research Center, Kitakami, Iwate 024-0003, Japan - - 2014
Bud dormancy is an adaptive strategy that perennials use to survive unfavorable conditions. Gentians (Gentiana), popular alpine flowers and ornamentals, produce overwintering buds (OWBs) that can persist through the winter, but the mechanisms regulating dormancy are currently unclear. In this study, we conducted targeted metabolome analysis to obtain clues about ...
Hu Li-Fang LF Key Laboratory for Space Bioscience and Biotechnology, Institute of Special Environmental Biophysics, School of Life Sciences, Northwestern Polytechnical University, Xi'an, 710072, - - 2014
Microgravity decreases the differentiation of osteoblast. However, as this process is multistage and complex, the mechanism by which microgravity inhibits osteoblast differentiation is still unclear. We have previously found that 24 h acute treatment of simulated microgravity (SM) in a random positioning machine (RPM) significantly inhibited the differentiation of preosteoblasts and ...
Takii Ryosuke R Department of Biochemistry and Molecular Biology, Yamaguchi University School of Medicine, Minami-Kogushi 1-1-1, Ube 755-8505, - - 2014
The Heat shock response is an evolutionally conserved adaptive response to high temperatures that controls proteostasis capacity, and is mainly regulated by an ancient heat shock factor (HSF). However, regulation of the stress-inducible HSF1 transcription complex on target genes has not yet been examined in detail in mammalian cells. In ...
Kang Hojin H Division of Pharmacology, Department of Molecular Cell Biology, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Suwon, Gyeonggi-do 440-746, Republic of - - 2014
The nucleolus is a compartment for the transcription of ribosomal RNA (rRNA) and assembly of ribosome subunits. Dysregulation of the nucleolus is considered to be a cellular stress event associated with aging and neurodegenerative disease, including Parkinson's disease (PD). We previously demonstrated that PARIS (PARkin Interacting Substrate, ZNF746) transcriptionally suppresses ...
Ricciardi Carolyn J CJ Department of Nutrition, University of Tennessee, 1215 W. Cumberland Ave, Knoxville, TN, 37996, - - 2014
The vitamin D system plays a role in metabolism regulation. 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) suppressed 3T3-L1 white adipocyte differentiation. Vitamin D receptor (VDR) knockout mice showed increased energy expenditure, whereas mice with adipose-specific VDR over-expression showed decreased energy expenditure. Brown adipose tissue (BAT), now known to be present in adult humans, ...
Hosokawa Mai M Department of Psychiatry, Course of Integrated Brain Sciences, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima, - - 2014
The aim of this study is to examine the hemodynamic changes induced by cognitive process of facial expression by using multichannel near-infrared spectroscopy (NIRS) in healthy subjects with varying degree of autism tendency. Subjects were 38 volunteers, 20 males and 18 females. Autism tendency was measured by the Autism Spectrum ...
Zimmer Cédric C School of Psychology and Neuroscience, University of St Andrews, St Andrews, United Kingdom, KY16 - - 2014
Stress exposure during early life development can program individual brain and physiology. The hypothalamic-pituitary-adrenal (HPA) axis is one of the primary targets of this programming which is generally associated with a hyperactive HPA axis, indicative of a reduced negative feedback. This reduced feedback efficiency usually results from a reduced level ...
Arcidiacono Maria Vittoria MV Renal Division, Washington University School of Medicine, St. Louis, MO, USA Division of Experimental Nephrology, IRB Lleida, Lleida, - - 2014
In secondary hyperparathyroidism (SHPT), enhanced parathyroid levels of transforming growth factor-α (TGFα) increase EGF receptor (EGFR) activation causing parathyroid hyperplasia, high parathyroid hormone (PTH) and also reductions in vitamin D receptor (VDR) that limit vitamin D suppression of SHPT. Since anti-EGFR therapy is not an option in human SHPT, we ...
Cheng Xin X Department of Histology & Embryology, Key Laboratory for Regenerative Medicine of the Ministry of Education, School of Medicine, Jinan University, Guangzhou 510632, - - 2014
Dexamethasone (Dex) has anti-inflammatory and immunomodulatory properties against many conditions. There is a potential teratogenic risk, however, for pregnant women receiving Dex treatment. It has been claimed that Dex exposure during pregnancy could affect osteogenesis in the developing embryo, which still remains highly controversial. In this study, we employed chick ...
Fu Zidong Donna ZD University of Kansas Medical Center, United - - 2014
Statins are effective cholesterol-lowering drugs to treat cardiovascular diseases. Bile acids (BAs), the end products of cholesterol metabolism in liver, are important nutrient and energy regulators. The present study aims to investigate how statins affect BA homeostasis in the enterohepatic circulation. Male C57BL/6 mice were treated with atorvastatin (100 mg/kg/day ...
España Laura L IHSM - - 2014
Tomato (Solanum lycopersicum L.) fruit ripening is accompanied by an increase in chalcone synthase (CHS) activity and flavonoid biosynthesis. Flavonoids accumulate in the cuticle giving its characteristic orange color that contributes to the eventual red color of the ripe fruit. Using virus-induced gene silencing (VIGS) in fruits we have down-regulated ...
Arakawa Keiko K Department of Psychology, State University of New York at Binghamton, Binghamton, N.Y., - - 2014
Exposure to stressors such as footshock leads to increased expression of multiple inflammatory factors, including the pro-inflammatory cytokine interleukin-1 (IL-1) in the brain. Studies have indicated that there are sex differences in stress reactivity, suggesting that the fluctuation of gonadal steroid levels across the estrous cycle may play a regulatory ...
Yoshizaki Norihiro N Advanced Technology Research Laboratory, NOF Corporation, - - 2014
Ultraviolet light (UV) induces an inflammatory response in the skin by cyclooxygenase (COX)-2 expression and prostaglandin (PG) E2 production. Citrus peel has been used as a natural medicine. It contains polymethoxyflavonoids (PMFs) as a major ingredient, which have anti-inflammatory activity. We obtained orange peel extract containing high levels of PMFs. ...
Hua Xia X Ocular Surface Center, Cullen Eye Institute, Department of Ophthalmology, Baylor College of Medicine , Houston, TX , USA - - 2014
Abstract Purpose: To explore the effects of osmoprotectants on pro-inflammatory mediator production in primary human corneal epithelial cells (HCECs) exposed to hyperosmotic stress. Methods: HCECs cultured in iso-osmolar medium (312 mOsM) were switched to hyperosmotic media with or without prior incubation with 2-20 mM of l-carnitine, erythritol or betaine for different ...
Campbell Michael M Penn State Erie, The Behrend College, School of Science, 4205 College Drive, Erie, PA, 16563, USA, - - 2014
Perennial plants undergo repression of meristematic activity in a process called dormancy. Dormancy is a complex metabolic process with implications for plant breeding and crop yield. Endodormancy, a specific subclass of dormancy, is characteristic of internal physiological mechanisms resulting in growth suppression. In this study, we examine transcriptional changes associated ...
Ma Biao B State Key Lab of Plant Genomics, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, - - 2014
Ethylene and abscisic acid (ABA) have a complicated interplay in many developmental processes. Their interaction in rice is largely unclear. Here, we characterized a rice ethylene-response mutant mhz4, which exhibited reduced ethylene-response in roots but enhanced ethylene-response in coleoptiles of etiolated seedlings. MHZ4 was identified through map-based cloning and encoded ...
Gao Lin L Department of Surgery and Biomedical Engineering, Beckman Laser Institute and Medical Clinic, University of California, Irvine, 92612, California; Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, - - 2014
Administration of topical rapamycin (RPM) suppresses the regeneration and revascularization of photocoagulated blood vessels induced by pulsed dye laser (PDL). To systematically elucidate the molecular pathophysiology of the inhibition of PDL-induced angiogenesis by topical RPM in a rodent model. The mRNA expression profiles of 86 angiogenic genes and phosphorylation levels ...
Saul Nadine N Department of Biology, Freshwater and Stress Ecology, Humboldt-Universität zu Berlin, Späthstr. 80/81, 12437 Berlin, Germany. Electronic address: - - 2014
Cyanobacterial blooms in aquatic environments are frequently characterized by elevated levels of microcystins, a potent hepatotoxin. Here we exposed the nematode Caenorhabditis elegans with environmentally realistic concentrations of MC-LR to explore its non-hepatic toxicity. Lifespan, reproduction and growth assays confirmed the toxic potential of 100μg/L MC-LR even in this liver-lacking ...
Zhen He H Hubei Key Laboratory of Genetic Regulation and Integrative Biology, College of Life Sciences, Central China Normal University, Wuhan, 430079, - - 2014
In order to explore the impact of mercury on fish, zebrafish were exposed in various levels of HgCl2 and the superoxide dismutase (SOD), acetylcholinesterase (AChE) activities were measured after 1 and 7 days exposure. Muscle RNA was also extracted for semi-quantitative RT-PCR determination of the expression of AChE, CYP1A1, Cu/Zn-SOD. It ...
Park Kyung Soo KS Department of Immunology, University of Pittsburgh, Pittsburgh, PA 15261; - - 2014
Differentiation of B cells into Ab-secreting cells induces changes in gene transcription, IgH RNA processing, the unfolded protein response (UPR), and cell architecture. The transcription elongation factor eleven nineteen lysine-rich leukemia gene (ELL2) stimulates the processing of the secreted form of the IgH mRNA from the H chain gene. Mice ...
Majerciak Vladimir V Tumor Virus RNA Biology Section, Gene Regulation and Chromosome Biology Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland 21702, - - 2014
Kaposi sarcoma-associated herpesvirus (KSHV) ORF57 is a multifunctional post-transcriptional regulator essential for viral gene expression during KSHV lytic infection. ORF57 requires interactions with various cellular proteins for its function. Here, we identified serine/arginine-rich splicing factor 3 (SRSF3, formerly known as SRp20) as a cellular cofactor involved in ORF57-mediated splicing of ...
Choi Jae-Ho JH 1 Department of Food Science and Biotechnology, College of Agriculture and Life Sciences, Kangwon National University , Chuncheon, - - 2014
Abstract Sasang constitutional medicine is a major branch of Korean traditional oriental medicine. Constitutions of Sasang medicine are classified into Taeyangin, Taeumin, Soyangin, and Soumin. We investigated immunostimulatory activities of fermented soybean product (FSP) extracts and their major bioactive compounds, isoflavone glycosides in primary immune cells isolated from the blood ...
Li Wei W Howard Hughes Medical Institute, Department of Molecular Biology, Princeton University, Princeton, NJ 08544, - - 2014
In Drosophila melanogaster, the anteroposterior (AP) and dorsoventral (DV) axes of the oocyte and future embryo are established through the localization and translational regulation of gurken (grk) mRNA. This process involves binding of specific factors to the RNA during transport and a dynamic remodeling of the grk-containing ribonucleoprotein (RNP) complexes ...
Zhu Bin B College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi 712100, - - 2014
Trifloxystrobin (TFS) is the widely used strobilurin fungicide. However, little information is so far available regarding the uptake kinetics and developmental toxicity of TFS to fish. The present study was conducted to investigate the uptake kinetics, potential environment risk and toxicity of TFS on Gobiocypris rarus embryos. Results revealed that ...
Yang Heping H University of Southern Calfornia, Keck School of Medicine, Division of Gastroenterology and Liver Diseases, USC Research Center for Liver Diseases, Los Angeles , California, United States ; - - 2014
Aims: We showed chronic cholestatic liver injury induced the expression of c-Myc but suppressed that of glutamate-cysteine ligase (GCL, composed of catalytic and modifier subunits GCLC and GCLM, respectively). This was associated with reduced nuclear antioxidant response element (ARE) binding by nuclear factor-erythroid 2 related factor 2 (Nrf2). Here we ...
Piesiewicz Aneta A Department of Animal Physiology, Faculty of Biology, University of Warsaw , - - 2014
Previously, we have demonstrated the postembryonic development of chicken (Gallus gallus domesticus L.) pineal gland functions expressed as changes in melatonin (MEL) biosynthesis. Pineal concentrations of MEL and its precursor serotonin (5-HT) were shown to increase between the 2nd and 16th day of life. We also found that levels of ...
Li Jie J Center for Theoretical and Applied Neuro-Oncology, Division of Neurosurgery, University of California, San Diego. Contributed equally to this - - 2014
The intrinsic signaling cascades and cell states associated with the Glioma CpG Island Methylator Phenotype (G-CIMP) remain poorly understood. Using published mRNA signatures associated with EGFR activation, we demonstrate that G-CIMP+ tumors harbor decreased EGFR signaling using three independent datasets, including the Chinese Glioma Genome Atlas(CGGA; n=155), the REMBRANDT dataset ...
Lee Gong-Rak GR Department of Medical Science, School of Medicine, University of Ulsan, Ulsan, - - 2014
Cholangiocarcinoma is one of the most difficult malignancies to cure. An important prognostic factor is metastasis, which precludes curative surgical resection. Recent evidence shows that capsaicin has an inhibitory effect on cancer cell migration and invasion. Here, we investigated the molecular mechanism of the capsaicin-induced anti-migration and anti-invasion effects on ...
Yang Xiangshan X Department of Pathology, Affiliated Hospital of Shandong Academy of Medical Sciences, Jinan, Shandong, - - 2014
Smad signalling plays an important role in the neurobiology, which can be induced by bone morphogenetic protein 2 (BMP2) and be regulated by endocytosis. However, it is still unclear whether endocytosis regulates BMP2-Smad-mediated proliferation and neurite growth in SH-SY5Y. Here we investigated the effects of endocytosis on BMP2-mediated Smad signallings ...
Huang Mingkun M College of Horticulture, Center of Flower Research, South China Agricultural University, Guangzhou, 510642, - - 2014
Methyl jasmonate (MeJA) is one of most abundant scent compounds in Cymbidium ensifolium flowers. In this study the emission of MeJA and its regulation mechanism were investigated. Our results showed that emission of MeJA in C. ensifolium flowers was controlled developmentally and rhythmically. It occurred in a tissue-specific manner and ...
Liu Han H Department of Veterinary Medicine, Agricultural College, Guangdong Ocean University, Zhanjiang, 524088, - - 2014
3,3',4,4',5-Pentachlorobiphenyl (PCB126) cause multiple adverse effects in organisms including animals and humans. Although PCB toxicities are linked to oxidative damage in rodents, the mechanism in early life stages of zebrafish is not clear. To explore the developmental toxicity mechanism of PCB126, three paradigms (toxicological phenotypes, biochemical changes, and molecular changes) ...
Dayang Wu W Department of Ophthalmology, The First Affiliated Hospital of Liaoning Medical University , Jinzhou , P.R. China - - 2014
Abstract Background: The massive uptake of compatible osmolytes is a self-protective response shared by retina exposed to hypertonic stress and ultraviolet stress. Objective: This study aimed to investigate the protective effects of taurine against ultraviolet damage in human retinal pigment epithelium cells. Methods: Real-time PCR, radioimmunoassay, ELISA and immunoassay were ...
Park Chan Jin CJ Department of Life Science and Institute for Natural Sciences, Hanyang University, Seoul 133-791, South - - 2014
This study aimed to elucidate the mechanisms by which alkylphenols disrupt endocrine function in wild amphibians in Korea. To this end, the effects of 4-tert-octylphenol (OP), 17β-estradiol (E2), and estrogen receptor (ER) agonists on the expression profiles of vitellogenin (VTG) and ERs were examined in livers obtained from male Bombina ...
Zannetti Claudia C International Center for Infectiology Research, University of Lyon, Lyon 69007, France; Inserm, U1111, Lyon 69007, France; Ecole Normale Supérieure de Lyon, Lyon 69007, France; Université Claude Bernard Lyon 1, Centre International de Recherche en Infectiologie, Lyon 69100, France; Centre National de la Recherche Scientifique, Unité Mixte de Recherche 5308, Lyon 69007, France; Oncovirus et l'immunité innée, Hospices Civils de Lyon Sud, Pierre Benite, 69495 - - 2014
The stimulation of TLRs by pathogen-derived molecules leads to the production of proinflammatory cytokines. Because uncontrolled inflammation can be life threatening, TLR regulation is important; however, few studies have identified the signaling pathways that contribute to the modulation of TLR expression. In this study, we examined the relationship between activation ...
Song Jinsoo J Department of Biological Sciences, College of Natural Sciences, Iksan, Chunbuk, 570-749, - - 2014
Growth Arrest-Specific 5 (GAS5) is known to negatively regulate cell survival and is aberrantly expressed in several cancers. The influence of GAS5 on osteoarthritis (OA) has not been determined. To address this, articular chondrocytes were isolated from relatively normal (Non-OA) and clear OA regions (OA) of cartilage in total knee ...
Wen Yinxian Y Department of Orthopedic Surgery, Zhongnan Hospital of Wuhan University, Wuhan 430071, China. Electronic address: - - 2014
UDP-galactose-4-epimerase (GALE) is a key enzyme catalyzing the interconversion of UDP-glucose and UDP-galactose, as well as UDP-N-acetylglucosamine and UDP-N-acetylgalactosamine, which are all precursors for the proteoglycans (PGs) synthesis. However, whether GALE is essential in cartilage homeostasis remains unknown. Therefore, we investigated the role of GALE in PGs synthesis of human ...
Jiang Xiaoying X Xi'an Jiaotong University Department of Genetics and Molecular Biology, School of Medicine 76 Yanta West Road Xi'an, Shaanxi 710061 China University of Manchester NIHR Translational Research Facility in Respiratory Medicine Group, School of Translational Medicine Manchester - - 2014
It was known that IL-1β-induced rapid expression of miR-146a, which regulated the secretion of inflammatory chemokines in human A549 alveolar epithelial cells. However, little is known about the level of primary miR-146a and the downstream biogenesis of miR-146a in A549 cells. We examined the levels of primary miR-146a and mature ...
Ortner Viktoria V Department of Applied Life Sciences, University of Applied Sciences, FH Campus Wien, Helmut-Qualtinger-Gasse 2, A-1030, Vienna, - - 2014
Detection of cellular stress is of major importance for the survival of cells. During evolution, a network of stress pathways developed, with the heat shock (HS) response playing a major role. The key transcription factor mediating HS signalling activity in mammalian cells is the HS factor HSF1. When activated it ...
Hsieh Yih-Shou YS Institute of Biochemistry and Biotechnology, - - 2014
Hypothalamic neuropeptides, including neuropeptide Y (NPY) and proopiomelanocortin (POMC), have been found to control the appetite-suppressing effect of amphetamine (AMPH). In the present study, we have examined whether dopamine receptor (DAR), phosphatidylinositol 3-kinase (PI3K), and nuclear factor-kappaB (NF-κB) are involved in AMPH's action. We administered AMPH to rats once a ...
Rhiu Soolienah S DOngtan Sacred Heart Hospital, Hallym University College of Medicine, Gangnam-gu Apgujung-dong, Seoul, 135-787, Korea (South), Republic - - 2014
Purpose: We investigated the therapeutic effect of nontoxic concentrations of tanshinone IIA (TanIIA) from Salvia miltiorrhiza in primary cultures of orbital fibroblasts from Graves' orbitopathy (GO). Methods: The effect of TanIIA on interleukin (IL)-1β-induced proinflammatory cytokine (IL-6, IL-8, MCP-1) expression was determined by real-time PCR. Anti-oxidant activity was investigated by ...
Srivastava Amrita A Department of Zoology, University of Lucknow, Lucknow 226007, - - 2014
Less is known about genetic basis of photoperiodic regulation of reproductive cycle in subtropical birds. This study measured the expression levels of DIO2, DIO3, GnRH, and GnIH genes in Indian weaver birds subjected to short days (8h light: 16 h darkness, 8L:16D) and long days (16L:8D) for 48 weeks. Whereas ...
Slater Jill Drappole Med Wayne Edu JD Wayne State University, Physiology, detroit, Michigan, United States ; - - 2014
Extracellular stresses influence transcription factor (TF) expression and therefore lineage identity in the peri-implantation mouse embryo and its stem cells. This potentially affects pregnancy outcome. To understand the effects of stress signaling during this critical period of pregnancy, we exposed cultured murine embryonic stem cells (mESCs) to hyperosmotic stress. We ...
Kwon Tae-Hyung TH Gyeongbuk Institute for Marine Bio-Industry, Uljin, 767-813, Republic of Korea; Food Science and Biotechnology Major, Andong National University, Andong, 760-749, Republic of - - 2014
Brown alga, have been used for their nutritional value as well as a source of bioactive compounds with antioxidant, anti-inflammatory, antimicrobial, and anti-obesity effects. Obesity is an important condition implicated in various diseases, including diabetes, hypertension, dyslipidemia, and coronary heart disease. However, anti-obesity effects of the Eisenia bicyclis remain unknown. ...
Tomar Dhanendra D Department of Cell Biology, School of Biological Sciences and Biotechnology, Indian Institute of Advanced Research, Gandhinagar, - - 2014
The NF-κB family of transcription factors is activated in response to various intracellular or extracellular stimuli and its dysregulation leads to pathological conditions like infection, cancer, neurodegenerative disorders. The post-translational modification by ubiquitination regulates various steps of NF-κB pathway. In the current study, we have described the role of TRIM13, ...
Li Li L Department of Pharmacy, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, P.R. - - 2014
Ginseng has become one of the most commonly used alternative herbal medicines, and its active component, ginsenoside Rg1 has known pharmacological effects, including anticancer properties. However, the effects of ginsenoside Rg1 on metastasis have yet to be investigated. In this study, we demonstrated the ability of ginsenoside Rg1 to suppress ...
Zhang Chong C Department of Human Anatomy, Histology and Embryology, Fourth Military Medical University, No. 169 Changle West Road, Xi'an 710032, China; Department of General Surgery, 3rd Hospital of PLA, No. 45 Dongfeng Road, Bao Ji 721004, - - 2014
Epigenetic silencing mechanisms are essential for regulating germ cell apoptosis in response to different stimuli during complicated spermatogenesis. Herein, we report the potential signaling events related to up-regulation of Metastasis associated protein 1 (Mta1), a master chromatin modifier, during mono-(2-ethylhexyl) phthalate (MEHP)-induced Sertoli cells (SCs) injury. Mta1 up-regulation correlated to ...
Genovese G G Laboratorio de Ecotoxicología Acuática, Departamento de Biodiversidad y Biología Experimental, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, C1428EGA, Argentina; IBBEA, CONICET-UBA, Argentina. Electronic address: - - 2014
In oviparous vertebrates, vitellogenin (VTG) is mainly produced by the liver in response to estrogen (E2) and its synthesis is traditionally coupled to estrogen receptor alpha induction. Even though VTG is a female-specific protein, chemicals that mimic natural estrogens, known as xenoestrogens, can activate its expression in males causing endocrine ...
Ovrevik Johan - - 2014
The aryl hydrocarbon receptor (AhR) has gradually emerged as a regulator of inflammation in the lung and other tissues. AhR may interact with the p65-subunit of the nuclear factor (NF)-κB transcription factors, but reported outcomes of AhR/NF-κB-interactions are conflicting. Some studies suggest that AhR possess pro-inflammatory activities while others suggest ...
Cheung Cecilia Y CY OHSU - - 2014
Introduction: We hypothesized that prostaglandin E2 (PGE2) stimulates amniotic fluid transport across the amnion by upregulating vascular endothelial growth factor (VEGF) expression in amnion cells and that amniotic PGE2 concentration correlates positively with intramembranous (IM) absorption rate in fetal sheep. Methods: The effects of PGE2 at a range of concentrations ...
Wang Lijuan L Department of Clinical Pharmacology, College of Pharmacy, Dalian Medical University, Dalian, Liaoning, PR China. Electronic address: - - 2014
The purpose of this study was to investigate the enhancing effect of dioscin on the absorption of methotrexate (MTX) and clarify the molecular mechanism involved in vivo and in vitro. Dioscin increased MTX chemosensitivity and transepithelial flux in the absorptive direction, significantly inhibiting multidrug resistance 1 (MDR1) mRNA and protein ...
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