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Park Minji - - 2014
BackgroundThe important role of WT1 in early folliculogenesis was evident from its restricted expression pattern in immature follicles and from its involvement in transcriptional control of inhibin-¿ and FSH receptor. There is also considerable evidence that WT1 is a potent inhibitor of apoptotic cell death in the developing kidney and ...
Liu Yuanyuan Y Department of Botany, University of British Columbia, Vancouver, British Columbia V6T1Z4, - - 2014
The TALE homeodomain transcription factor KNOTTED ARABIDOPSIS THALIANA7 (KNAT7) is part of a regulatory network governing the commitment to secondary cell wall biosynthesis of Arabidopsis thaliana, where it contributes to negative regulation of this process. Here, we report that BLH6, a BELL1-LIKE HOMEODOMAIN protein, specifically interacts with KNAT7, and this ...
Sharma Deepika D CSIR-National Botanical Research Institute, Council of Scientific and Industrial Research (CSIR-NBRI), Rana Pratap Marg, Lucknow-226001, India. prabodht@hotmail.com - - 2014
Arsenic (As) contamination of rice (Oryza sativa) imposes a serious threat to human health worldwide. Understanding the molecular mechanisms of As transport and accumulation in rice may provide promising solutions to the problem. MicroRNAs (miRNAs) are a novel class of short, endogenous, non-coding small RNA molecules involved in a wide ...
Olufsen Marianne M Department of Biology, Norwegian University of Science and Technology (NTNU), Høyskoleringen 5, 7491, Trondheim, - - 2014
The effects of hypoxia and perfluorooctane sulfonamide (PFOSA), given singly and also in combination on endocrine, biotransformation, and oxidative stress responses were investigated in primary culture of salmon hepatocytes. Hypoxia was induced chemically using cobalt chloride (CoCl2) or deferroxamine (DFO). Primary culture of salmon hepatocytes were exposed to either CoCl2 ...
Wen Yinxian - - 2014
IntroductionTo investigate the possible role of UDP-glucose dehydrogenase (UGDH) in osteoarthritis (OA) and uncover whether, furthermore how interleukin-1beta (IL-1ß) affects UGDH gene expression.Methods UGDH specific siRNAs were applied to determine the role of UGDH in proteoglycan (PG) synthesis in human articular chondrocytes. Protein levels of UGDH and Sp1 in human ...
Kowalewski Mariusz Pawel MP Institute of Veterinary Anatomy, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland. Electronic address: - - 2014
The adaptive responses to hypoxia are mediated by hypoxia-inducible factor 1 alpha (HIF1α). Its role, however, in regulating steroidogenesis remains poorly understood. We examined the role of hypoxia and HIF1α in regulating steroid acute regulatory protein (STAR) expression and steroidogenesis in immortalized (KK1) mouse granulosa cells under progressively lowering O2 ...
Zhong Ruiqin R Department of Plant Biology, University of Georgia, Athens, GA 30602, - - 2014
Secondary walls in the form of wood and fibers are the most abundant biomass produced by vascular plants, and are important raw materials for many industrial uses. Understanding how secondary walls are constructed is of significance in basic plant biology and also has far-reaching implications in genetic engineering of plant ...
Ferraro S M SM Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autónoma de México, México - - 2014
Nutritional supplementation before breeding (flushing) has become a common practice and is a reliable method to increase lambing and twining rates in sheep. We have shown that ultrashort flushing (USF: 1 day long) acutely increases ovulation rate without affecting the body condition or animal weight. A short nutritional stimulus would ...
Honda Kazuhisa K Department of Bioresource Science, Graduate School of Agricultural Science, Kobe University, Kobe, - - 2014
Various lines of evidence suggest that appetite-related neuropeptides in the hypothalamus are regulated by adiposity signals such as leptin and insulin in mammals. In the present study, we examined age-dependent changes in the weight of abdominal fat and hypothalamic mRNA levels of neuropeptide Y (NPY, an orexigenic neuropeptide) and proopiomelanocortin ...
Payyavula Raja S RS Irrigated Agricultural Research and Extension Center, Washington State University, Prosser, WA, - - 2014
Chlorogenic acid (CGA) is the major phenolic sink in potato tubers and can constitute over 90% of total phenylpropanoids. The regulation of CGA biosynthesis in potato and the role of the CGA biosynthetic gene hydroxycinnamoyl CoA:quinate hydroxycinnamoyl transferase (HQT) was characterized. A sucrose induced accumulation of CGA correlated with the ...
Yamada Takanori T Department of Gastroenterology, Iwata City Hospital, Iwata, - - 2014
Background/Aims: Induction by bile acid of caudal type homeobox 2 (CDX2) and cyclooxygenase-2 (COX-2) expression via nuclear factor-κB (NF-κB) activation is a critical event in the development of Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC). Guggulsterone (GS) is a plant sterol that inhibits NF-κB activity. Here, we evaluated whether GS ...
Vazzana Mirella M Dept. STEBICEF, Università degli Studi di Palermo, Via Archirafi, 18 - 90123 Palermo, - - 2014
Wound repair is a key event in the regeneration mechanisms of echinoderms. We studied, at the behavioural, cellular and molecular levels, the wound healing processes in Holothuria tubulosa after injuries to the body wall. The experiments were performed for periods of up to 72 hours, and various coelomocyte counts, as ...
Krause J S JS Department of Neurobiology, Physiology and Behaviour, University of California, One Shields Avenue, Davis, CA, 95616, - - 2014
The acute stress response in vertebrates is a highly adaptive suite of physiological and behavioural mechanisms that promote survival in the face of deleterious stimuli from the environment. Facultative changes of physiology and behaviour are mediated through changes in circulating levels of glucocorticoids (corticosterone, cortisol) and their subsequent binding to ...
Reyes-Becerril Martha M Centro de Investigaciones Biológicas del Noroeste (CIBNOR), Mar Bermejo 195, Col. Playa Palo de Santa Rita, La Paz, B.C.S. 23090, - - 2014
Aquaculture production of Pacific red snapper Lutjanus peru is growing rapidly in Mexico, especially in Gulf of California. As it is a relatively new aquaculture species there are few reports evaluating its immune response to pathogens. The Gram-negative bacteria Aeromonas veronii is a heterogeneous organism that causes the disease known ...
Faralli Jennifer A JA Departments of Pathology & Laboratory Medicine, University of Wisconsin, Madison, WI 53706, USA. Electronic address: - - 2014
Mutations in the myocilin gene (MYOC) account for 10% of juvenile open-angle glaucoma cases and 3-4% of adult onset primary open-angle glaucoma cases. It is a secreted glycoprotein found in many ocular and non-ocular tissues and has been linked to elevated intraocular pressure. In human trabecular meshwork (HTM) cells, MYOC ...
Telonis-Scott Marina M School of Biological Sciences, Monash University, Clayton, 3800, Victoria, - - 2014
The cellular stress response has long been the primary model for studying the molecular basis of thermal adaptation, yet the link between gene expression, RNA metabolism and physiological responses to thermal stress remains largely unexplored. We address this by comparing the transcriptional and physiological responses of three geographically distinct populations ...
Yu Yuan Y Department of Nephrology, The Second Affiliated Hospital, Chongqing Medical University, Chongqing 400010, P.R. - - 2014
Elevated plasma low‑density lipoprotein (LDL) is associated with systemic inflammation, and is an important factor in the pathogenesis of chronic kidney disease. The aim of the present study was to investigate the effects of endoplasmic reticulum (ER) stress preconditioning on LDL‑induced inflammatory responses, in human mesangial cells (HMCs). HMCs were ...
Lee Schuyler S University of Colorado-Boulder, United - - 2014
Mutations in several genes, including PINK1 and Parkin, are known to cause autosomal recessive cases of Parkinsons disease in humans. These genes operate in the same pathway and play a crucial role in mitochondrial dynamics and maintenance. PINK1 is required to recruit Parkin to mitochondria and initiate mitophagy upon mitochondrial ...
Taniguchi Mai M Department of Molecular Biochemistry, Graduate School of Life Science, University of - - 2014
The Golgi stress response is a mechanism by which, under conditions of insufficient Golgi function (Golgi stress), the transcription of Golgi-related genes is upregulated through an enhancer, the Golgi apparatus stress response element (GASE), in order to maintain homeostasis in the Golgi. The molecular mechanisms associated with GASE remain to ...
Prokkola Jenni M JM Laboratory of Animal Physiology, Department of Biology, University of Turku, 20014, Finland. Electronic address: - - 2014
Pollution with low concentrations of pharmaceuticals, especially when combined with low-oxygen conditions (hypoxia), is a threat to aquatic ecosystems worldwide. The non-steroidal anti-inflammatory drug diclofenac is commonly detected in wastewater effluents, and has potential to accumulate in the bile of fish. Diclofenac has been shown to activate aryl hydrocarbon receptor ...
Feidantsis Konstantinos K Laboratory of Animal Physiology, Department of Zoology, Faculty of Science, School of Biology, Aristotle University of Thessaloniki, 54124, Thessaloniki, - - 2014
The present study assesses the resilience of the Mediterranean gilthead seabream (Sparus aurata) to acute warming and water acidification, using cellular indicators of systemic to molecular responses to various temperatures and CO2 concentrations. Tissue metabolic capacity derived from enzyme measurements, citrate synthase, 3-hydroxyacyl CoA dehydrogenase (HOAD), as well as lactate ...
Bradley Elizabeth W EW Mayo Clinic, United - - 2014
Histone deacetylases (Hdacs) regulate endochondral ossification by suppressing gene transcription and modulating cellular responses to growth factors and cytokines. We previously showed that Hdac7 suppresses Runx2 activity and osteoblast differentiation. In this study, we examined the role of Hdac7 in postnatal chondrocytes. Hdac7 was highly expressed in proliferating cells within ...
Schmidt Ulrike U Max Planck Institute of Psychiatry, Department of Clinical Research, RG Molecular Psychotraumatology, Munich, Germany. Electronic address: - - 2014
Both the molecular co-chaperone FKBP51 and the presynaptic vesicle protein synapsin (alternatively spliced from SYN1-3) are intensively discussed players in the still insufficiently explored pathobiology of psychiatric disorders such as major depression, schizophrenia and posttraumatic stress disorder (PTSD). To address their still unknown interaction, we compared the expression levels of ...
Bae Seunghee S Molecular-Targeted Drug Research Center and Korea Institute for Skin and Clinical Sciences, Konkuk University, Seoul 143-701, Republic of - - 2014
Exposure to high-dose ionizing radiation, including γ-radiation, induces severe skin disorders. However, the biological consequences and molecular mechanisms responsible for the response of human skin to low-dose γ-radiation (LDR) are largely unknown. In the present study, we demonstrate that LDR (0.1 Gy) induces distinct cellular responses in normal human dermal fibroblasts (NHDFs) ...
Li Zong-Zhuang ZZ Department of Cardiology, Shanghai First People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200080, - - 2014
The ability of nicotine to induce aortic aneurysms has been shown in animal models; however, its underlying mechanisms remain elusive. In the present experiment, both the RAW264.7 and MOVAS cell lines were employed to examine the nicotine-induced modulation of VCAM-1, MMP-2, and MMP-9 expressions in macrophages and vascular smooth muscle ...
Chen Ting T CAS Key Laboratory of Tropical Marine Bio-resources and Ecology (LMB), Key Laboratory of Applied Marine Biology of Guangdong Province and Chinese Academy of Sciences (LAMB), South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, China. Electronic address: - - 2014
Nitric oxide (NO) is a key effector molecule produced in the innate immune systems of many species for antimicrobial defense. However, how NO production is regulated during bacterial infection in invertebrates, especially crustaceans, remains poorly understood. Vibrio harveyi, a Gram-negative marine pathogen, is among the most prevalent and serious threats ...
Zhu Lili L Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes of Biological Sciences Chinese Academy of Sciences/Shanghai JiaoTong University School of Medicine, Shanghai, - - 2014
Pluripotency-associated transcription factor Foxd3 is required for maintaining pluripotent cells. However, molecular mechanisms underlying its function are largely unknown. Here, we report that Foxd3 suppresses differentiation induced by calcineurin-NFAT signaling to maintain the ESC identity. Mechanistically, Foxd3 interacts with NFAT proteins and recruits co-repressor Tle4, a member of the Tle ...
Chen Zhaowei Z Department of Burns and Plastic Surgery, Liao Cheng Hospital, Liao Cheng 252000, China. Electronic address: - - 2014
The aim of the present work was to investigate the mechanism of transforming growth factor (TGF)-β1 and Sloan-Kettering Institute (Ski) in the pathogenesis of hypertrophic scars (HS). Wound healing is an inherent process, but the aberrant wound healing of skin injury may lead to HS. There has been growing evidence ...
Yu Shibing - - 2014
Transcription factor activating protein 2 (AP2) plays an important role in cellular differentiation. Although profound craniofacial and long bone developmental abnormalities have been observed in AP2 knockout mice, the molecular effects of AP2 on osteoblasts are poorly defined. We demonstrated that AP2 regulates the expression of human frizzled 1 (FZD1), ...
Rubin Katarina A L KA AstraZeneca R&D Molndal - - 2014
Abstract The suppression of hepatic Cytochrome P450 (P450) expression during inflammatory and infectious diseases and the relief of this suppression by successful disease treatment have been previously demonstrated to impact drug disposition. To address this clinically relevant phenomenon preclinically, the effect of pro-inflammatory cytokines on P450 isoenzymes in human hepatocytes ...
Filichkin Sergei A SA Department of Botany and Plant Pathology, Oregon State University, Corvallis, Oregon, 97331, USA Center for Genome Research and Biocomputing, Oregon State University, Corvallis, Oregon, 97331, USA - - 2014
Environmental stresses profoundly altered accumulation of nonsense mRNAs including intron retaining (IR) transcripts in Arabidopsis. Temporal patterns of stress-induced IR mRNAs were dissected using both oscillating and non-oscillating transcripts. Broad range thermal cycles triggered a sharp increase in the long intron retaining CCA1 isoforms and altered their phasing to different ...
Pellizzaro Anthoni A Unité Mixte de Recherche 1345 Institut de Recherche en Horticulture et Semences (A.P., T.C., C.C., F.M., E.P., A.M.L., M.-C.M.-L.P.), and Laboratoire Récepteurs et Canaux Ioniques Membranaires, Equipe d'Accueil 2647, Unité Sous Contrat Institut National de la Recherche Agronomique 1330 (C.B., S.T., V.R.), Structure Fédérative de Recherche 4207 Qualité et Santé du Végétal, Université d'Angers, F-49045 Angers, France;Unité Mixte de Recherche 1345 Institut de Recherche en Horticulture et Semences, Institut National de la Recherche Agronomique, F-49071 Beaucouzé, France (A.P., T.C., C.C., F.M., E.P., A.M.L., M.-C.M.-L.P.); andImagerie Cellulaire, Structure Fédérative de Recherche 4207 Qualité et Santé du Végétal, Université d'Angers, F-49071 Beaucouzé, France - - 2014
Elongation of the primary root during postgermination of Medicago truncatula seedlings is a multigenic trait that is responsive to exogenous nitrate. A quantitative genetic approach suggested the involvement of the nitrate transporter MtNPF6.8 (for Medicago truncatula NITRATE TRANSPORTER1/PEPTIDE TRANSPORTER Family6.8) in the inhibition of primary root elongation by high exogenous ...
Chauhan S S SS Department of Animal Husbandry, Government of Himachal Pradesh, Shimla 171005, India Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, Vic 3010, - - 2014
The objective of this study was to investigate the effects of chronic heat (thermal) stress and dietary antioxidant supplementation on the expression of heat shock proteins and inflammatory genes in the skeletal muscle of sheep. Twenty-four Merino × Poll Dorset crossbred ewes were allocated to either a control (10 IU ...
Crambert Gilles G UPMC/INSERM/Paris Descartes U1138 CNRS ERL 8228, Equipe 3 Métabolisme et Physiologie Rénale, Centre de Recherche des Cordeliers, Paris, - - 2014
Large shifts of osmolality occur in the kidney medulla as part of the urine concentrating mechanism. Hyperosmotic stress profoundly challenges cellular homeostasis and induces endoplasmic reticulum (ER) stress. Here, we examined the unfolded protein response (UPR) in hyperosmotically-challenged principal cells of the kidney collecting duct (CD) and show its relevance ...
- - 2014
[This corrects the article DOI: 10.1371/journal.ppat.1004487.].
Centanni Samuel W SW Department of Neurosciences, Medical University of South Carolina, Charleston, South - - 2014
The long-term consequences of adolescent alcohol abuse that persist into adulthood are poorly understood and have not been widely investigated. We have shown that intermittent exposure to alcohol during adolescence decreased the amplitude of GABAA receptor (GABAA R)-mediated tonic currents in hippocampal dentate granule cells in adulthood. The aim of ...
Saunders David M V DM Toxicology Centre, University of Saskatchewan, 44 Campus Drive, Saskatoon, SK, Canada S7N 5B3. Electronic address: - - 2014
The novel brominated flame retardants (NBFRs), bis(2-ethylhexyl)-2,3,4,5-tetrabromophthalate (TBPH) and 2-ethylhexyl-2,3,4,5 tetrabromobenzoate (TBB) are components of the flame retardant mixture Firemaster 550 and both TBPH and TBB have recently been listed as high production volume chemicals by the US EPA. These NBFRs have been detected in several environmental matrices but very ...
Kleber Astrid A Department of Anaesthesiology, Intensive Care and Pain Therapy, Saarland University Medical Center, Kirrbergerstrasse 57, 66421 Homburg /Saar, Germany. Electronic address: - - 2014
Melatonin's hepatoprotective actions have numerously been demonstrated in the past but the underlying molecular mechanisms are widely unknown. For a better understanding of melatonin's effects on hepatic stress response this study aimed to elucidate alterations in oxidative stress, unfolded protein response and acute phase response in septic mice. Male C3H/HeN ...
Dangi Satyaveer Singh SS Physiology and Climatology, Indian Veterinary Research Institute, Izatnagar, Bareilly, Uttar Pradesh, 243122, - - 2014
Menacing global rise in surface temperature compelled more focus of research over understanding heat stress response mechanism of animals and mitigation of heat stress. Twenty-four goats divided into four groups (n = 6) such as NHS (non-heat-stressed), HS (heat-stressed), HS + VC (heat-stressed administered with vitamin C), and HS + VE + Se (heat-stressed administered with vitamin E ...
Shin Nara N Department of Bioscience & Biotechnology/Institute of Bioscience, BK21 Graduate Program, Sejong University, Seoul 143-747, Republic of - - 2014
Among the members of the additional sex comb-like (ASXL) family, ASXL3 remains unexplored. Here, we showed that ASXL3 interacts with HP1α and LSD1, leading to transcriptional repression. We determined that ASXL3 depletion augments the ligand-induced transcriptional activities of LXRα and TRβ, which were repressed by ASXL3 overexpression. The ligand-dependent interactions ...
Liu Ying Y Shandong Provincial Key Laboratory of Water Pollution Control and Resource Reuse, School of Environmental Science and Engineering, Shandong University, Jinan, 250100, People's Republic of China, - - 2014
The responses of Microcystis aeruginosa under exposure to spiramycin and amoxicillin were investigated on both cellular and genetic levels through a 7-day exposure test. Algal growth was inhibited by spiramycin while promoted by amoxicillin at test concentrations of 0.6-1.8 μg L(-1), indicating a higher toxicity of spiramycin than amoxicillin. During the whole ...
Yuan Chao C Key Laboratory for Molecular Animal Nutrition of Ministry of Education, Feed Science Institute, College of Animal Science, Zhejiang University (Zijingang Campus), Hangzhou, 310058, - - 2014
L-arginine (L-Arg) uptake is mediated by members of cationic amino acid transporter (CAT) family and may coincide with the induction of nitric oxide synthases (NOS). The present study was conducted to investigate the extracellular concentrations of L-Arg regulating the CAT-1, CAT-4 and inducible NOS (iNOS) in chick intestinal epithelial cells. ...
Kee Hae Jin HJ Cardiovascular Convergence Research Center, Chonnam National University Hospital, Gwangju, 501-757, South - - 2014
Sulforaphane is a naturally occurring isothiocynate compound found in cruciferous vegetables. Here we report the effect of sulforaphane on cardiac hypertrophy and propose an underlying mechanism. Sulforaphane suppresses cardiomyocyte hypertrophy induced by hypertrophic stimuli in vitro and in vivo. Sulforaphane suppresses the expressions of fetal genes, including ANP, BNP, and ...
Garmash Elena V EV Institute of Biology, Komi Science Centre, Ural Branch, Russian Academy of Sciences, 28 Kommunisticheskaya Str., 167982 Syktyvkar, Russia. Electronic address: - - 2014
This study deals with effects of de-etiolation (48h) of spring wheat (Triticum aestivum L., var. Irgina) seedlings on differential expression of AOX1 genes, levels of AOX protein and the alternative respiratory pathway (AP) capacity. As a result of exposure to continuous irradiation of dark-grown wheat seedlings, the respiratory activity and ...
Hu Li-Fang LF Key Laboratory for Space Bioscience and Biotechnology, Institute of Special Environmental Biophysics, School of Life Sciences, Northwestern Polytechnical University, Xi'an, 710072, - - 2014
Microgravity decreases the differentiation of osteoblast. However, as this process is multistage and complex, the mechanism by which microgravity inhibits osteoblast differentiation is still unclear. We have previously found that 24 h acute treatment of simulated microgravity (SM) in a random positioning machine (RPM) significantly inhibited the differentiation of preosteoblasts and ...
Alva-Murillo Nayeli N Centro Multidisciplinario de Estudios en Biotecnología, Facultad de Medicina Veterinaria y Zootecnia, Universidad Michoacana de San Nicolás de Hidalgo, Km 9.5 Carr. Morelia-Zinapécuaro, Posta Veterinaria, C.P. 58893, Morelia, Michoacán, - - 2014
Vitamin D is an immunomodulator that exerts anti-inflammatory effects. In this work, the effects of cholecalciferol, a vitamin D precursor, on the inflammatory response of bovine mammary epithelial cells (bMECs) during the internalization of Staphylococcus aureus were analyzed. Cholecalciferol and S. aureus inhibited TLR2 mRNA expression, but cholecalciferol differentially modulated the ...
Takii Ryosuke R Department of Biochemistry and Molecular Biology, Yamaguchi University School of Medicine, Minami-Kogushi 1-1-1, Ube 755-8505, - - 2014
The Heat shock response is an evolutionally conserved adaptive response to high temperatures that controls proteostasis capacity, and is mainly regulated by an ancient heat shock factor (HSF). However, regulation of the stress-inducible HSF1 transcription complex on target genes has not yet been examined in detail in mammalian cells. In ...
Kang Hojin H Division of Pharmacology, Department of Molecular Cell Biology, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Suwon, Gyeonggi-do 440-746, Republic of - - 2014
The nucleolus is a compartment for the transcription of ribosomal RNA (rRNA) and assembly of ribosome subunits. Dysregulation of the nucleolus is considered to be a cellular stress event associated with aging and neurodegenerative disease, including Parkinson's disease (PD). We previously demonstrated that PARIS (PARkin Interacting Substrate, ZNF746) transcriptionally suppresses ...
Ricciardi Carolyn J CJ Department of Nutrition, University of Tennessee, 1215 W. Cumberland Ave, Knoxville, TN, 37996, - - 2014
The vitamin D system plays a role in metabolism regulation. 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) suppressed 3T3-L1 white adipocyte differentiation. Vitamin D receptor (VDR) knockout mice showed increased energy expenditure, whereas mice with adipose-specific VDR over-expression showed decreased energy expenditure. Brown adipose tissue (BAT), now known to be present in adult humans, ...
Hosokawa Mai M Department of Psychiatry, Course of Integrated Brain Sciences, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima, - - 2014
The aim of this study is to examine the hemodynamic changes induced by cognitive process of facial expression by using multichannel near-infrared spectroscopy (NIRS) in healthy subjects with varying degree of autism tendency. Subjects were 38 volunteers, 20 males and 18 females. Autism tendency was measured by the Autism Spectrum ...
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